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1 cytokine for release to neighboring cells in soluble form.
2 amine tracts and express these proteins in a soluble form.
3 ing three-fold greater in bound form than in soluble form.
4 at is proteolytically processed to release a soluble form.
5 hances RANKL expression, particularly in its soluble form.
6 nly investigated the biologic effects of the soluble form.
7 ssed in Escherichia coli and purified in the soluble form.
8 t a challenging target for design in a water-soluble form.
9 yme (TACE) to generate a biologically active soluble form.
10 d in NHBE cells and it remains active in its soluble form.
11 in Greek) to effectively assimilate iron in soluble form.
12 me-enriched fraction but also was present in soluble form.
13 n result in reactogenicity when delivered in soluble form.
14 IL-6 receptor and trans-signaling using its soluble form.
15 thermal and operational stability than their soluble form.
16 n, Env proteins are often made in truncated, soluble forms.
17 ll with an N-terminal protein S (PrS) tag in soluble forms.
18 X3CR1, signals both in membrane-anchored and soluble forms.
19 ive HtrABb occurs in both membrane-bound and soluble forms.
20 ble Abeta plaques and Abeta is likely in its soluble forms.
21 sis of carbon dioxide between gas- and water-soluble forms.
22 ity receptor for IgE, exists in membrane and soluble forms.
23 fusions were completely renatured in stable soluble forms.
24 products, recycling these compounds back to soluble forms.
25 tire ectodomain of PfEBA175 (PfEBA175 FL) in soluble form, allowing us to compare the biochemical and
26 ults demonstrate the existence of CL-12 in a soluble form and indicate a novel mechanism by which the
27 ly, a minority of D2R existed in a detergent-soluble form and interacted in a relatively unrestricted
28 sidues at the N terminus, can be purified in soluble form and is phosphorylated by cyclin-dependent k
31 orans alginate lyase known to be secreted in soluble form and to have a recognizable carbohydrate-bin
32 tinctive structural properties which include soluble forms and the absence of typical SLAM signaling
33 produced in bacterial recombinant host in a soluble form, and monoclonal antibodies (mAbs) were gene
34 genes, the presence of membrane-tethered and soluble forms, and a high degree of post-translational m
35 of Escherichia coli CsgG in a non-lipidated, soluble form as well as in its native membrane-extracted
36 eptor subunits can exist in surface-bound or soluble forms, as well as in isolation or in partnership
37 er, 90-95% of RhoGTPases are maintained in a soluble form by RhoGDI, which is generally viewed as a p
40 t growth factor-23 (FGF23) and a circulating soluble form (cKL) created by endoproteolytic cleavage o
41 Ag expressed by intact bacteria versus Ag in soluble form, CL-sensitive cells appear to be necessary
43 ght to investigate whether uric acid, in the soluble form, could also activate the NLRP3 inflammasome
44 n addition to being secreted from cells in a soluble form, CysC is released by cells in association w
45 NA isoforms have been described, including a soluble form detected in human serum, which may have an
46 addition to its ability to maintain iron in soluble form, EDDS acts as a superoxide radical-promotin
47 EnvD was recovered from inclusion bodies in soluble form from an Escherichia coli expression vector
48 B cells, and T cells, can be expressed as a soluble form generated by alternative splice variants an
50 s a result, STING agonists administered in a soluble form have elicited suboptimal immune responses.
53 HCC tissue and simultaneously augmented as a soluble form in HCC patients, particularly those with ad
56 g dual mitochondrial localization of Prx1: a soluble form in the intermembrane space and a form in th
59 on is an essential element for life, but its soluble form is scarce in the environment and is rarer i
62 s enzyme is regulated by its movement from a soluble form (largely in the nucleus) to a membrane-asso
63 tested in a panel of cancer cells, the water-soluble form of 3a, compound 8, displayed antiproliferat
65 s within the glycocalyx, and that it is this soluble form of any given chemokine that interacts with
66 31 of whom underwent challenge with the only soluble form of aspirin, lysine aspirin (LAS), to confir
67 diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to an
75 nto a construct that expresses a multitrimer soluble form of CD40L, leading to strongly protective CD
77 e severe pancreat CONCLUSIONS: : Activity of soluble form of CD73 at admission to hospital has progno
80 zyme-linked immunosorbent assay, activity of soluble form of CD73 using radioactive enzyme assays, an
81 g characteristic curve value for activity of soluble form of CD73 was 0.65 (95% CI, 0.51-0.80) among
82 ly, in the last-mentioned group, activity of soluble form of CD73 was better than C-reactive protein
85 d plasma enabled identification of a natural soluble form of CL-12 having an electrophoretic mobility
86 mined the three-dimensional structure of the soluble form of CPE in two crystal forms by X-ray crysta
88 nses of mice immunized with E1E2 and a novel soluble form of E1E2 (sE1E2) by a DNA prime and protein
94 proHB-EGF is known to be a precursor of the soluble form of HB-EGF (sHB-EGF), which promotes cell pr
97 of proprotein convertases, which releases a soluble form of HJV that suppresses BMP signaling and he
100 e previously shown that B7h triggering via a soluble form of ICOS (ICOS-Fc) inhibits the adhesion of
101 mIL-13Ralpha2 had no effect on levels of the soluble form of IL-13Ralpha2 in serum or BAL fluid and d
103 hat we developed, that a naturally occurring soluble form of IL-27Ralpha (sIL-27Ralpha) is produced b
104 It has been shown in several models that the soluble form of IL-6R (sIL-6R) is involved in the recrui
105 of the A allele increases expression of the soluble form of IL23R mRNA (which then functions as a de
108 s fibroblast growth factor 23 (FGF23), but a soluble form of Klotho is also produced by alternative s
109 Indeed, we further demonstrate that the soluble form of LRP1 (sLRP1) inhibits alpha(M)beta(2)-me
110 farction led to significant elevation of the soluble form of MerTK (myeloid-epithelial-reproductive t
114 blast growth factor 21 [FGF21], alphaKlotho, soluble form of mouse transforming growth factor-beta re
118 We engineered and heterologously expressed a soluble form of NUCB1 (sNUCB1) and characterized its bio
121 udy, we found that the expression of PTX3, a soluble form of pattern recognition receptor, was induce
125 (NTHI), those directed against a recombinant soluble form of PilA [the majority subunit of Type IV pi
127 P) that corresponds closely in sequence to a soluble form of PrP(C) shed from the cell surface by pro
128 gondii reveals that the parasite secretes a soluble form of PtdSer decarboxylase (TgPSD1), which pre
129 oxide compounds, a very concentrated and low-soluble form of Pu, which will serve as ongoing radioact
131 of integral membrane proteins that bind to a soluble form of silica, silicic acid, and transport it a
133 The median (interquartile range) value for soluble form of ST2 (33 [24.6-48.1] ng/mL) and galectin
135 ues less than the observed median (<33 ng/mL soluble form of ST2 and <17.8 ng/mL galectin 3) had redu
136 volume reduction varied by baseline level of soluble form of ST2 and galectin 3; patients with values
141 hibition of MSTN/activin A signaling using a soluble form of the activin type IIB receptor (ACVR2B),
142 muscle or by systemic administration of the soluble form of the activin type IIB receptor (ACVR2B/Fc
143 l-length CERK1 receptor protein as well as a soluble form of the CERK1 ectodomain, whereas cerk1-4 pl
144 expression, purification, and refolding of a soluble form of the CGRP receptor comprising a heterodim
151 ast, treatment of Tie1-deficient mice with a soluble form of the extracellular domain of Tie2, which
153 ons, and MVvac2-Hsol, vectoring a truncated, soluble form of the H protein that is secreted into the
158 d cirrhosis (67 with SBP) and quantified the soluble form of the mannose receptor (CD206) and tumor n
159 f you, and found that it mediates release in soluble form of the mature, cholesterol- and palmitate-m
161 a was subjected to extraction with the water-soluble form of the PAH receptor, ExBox.4Cl, resulting i
165 petitive inhibition of Pdpn functions with a soluble form of the protein, Pdpn-Fc, leads to reduced l
166 analysis revealed that the serum FcmuR is a soluble form of the receptor encoded by an alternatively
168 alveolar and plasma levels of cytokines and soluble form of the receptor for advanced glycation end-
169 ificant reduction over time in cytokines and soluble form of the receptor for advanced glycation end-
172 ly a single molecule of alphaSNAP binds to a soluble form of the SNARE complex, we find that three mo
174 udies have highlighted the appearance of the soluble form of the triggering receptor expressed on mye
176 mulated with GM-CSF secrete high levels of a soluble form of the VEGF receptor (sVEGFR-1), which neut
177 GM-CSF at low O(2) secrete high levels of a soluble form of the VEGF receptor 1 (sVEGFR-1), which ne
178 colony-stimulating factor (GM-CSF) produce a soluble form of the VEGF receptor-1 (sVEGFR-1), which ne
181 study, we characterized a previously unknown soluble form of this molecule in human plasma termed sCD
189 iting recombinant fusion proteins in which a soluble form of TRAIL, FasL or CD40L is genetically fuse
193 gths as those involved in the binding of the soluble form of ZipA, lacking the transmembrane region,
195 ween recognition core proteins and levels of soluble forms of Abeta 1-40 and 1-42 in both hippocampus
196 mulating body of evidence has indicated that soluble forms of Abeta and tau work together, independen
197 pathological hallmark of AD, but oligomeric, soluble forms of Abeta have been implicated as the synap
198 t gene expression of Abca1 and ApoE, reduces soluble forms of Abeta, and abrogates release of pro-inf
199 ions to promote the proteolytic clearance of soluble forms of Abeta, and we found that the synthetic
201 ed monoclonal antibody, preferentially binds soluble forms of amyloid and in preclinical studies prom
203 neural circuits, or protective, sequestering soluble forms of amyloid-beta (Abeta) that initiate syna
204 lts demonstrate that the N-terminal secreted soluble forms of APP (in particular sAPPbeta) robustly d
206 ll differentiation by producing membrane and soluble forms of CD25, the IL-2 receptor alpha-chain, an
208 Furthermore, although fVIII bound avidly to soluble forms of clusters II and IV from LRP1, only solu
210 n profile differs significantly from that of soluble forms of Env (gp120 or gp140) predominantly used
216 potency than noncomplexed trimers.IMPORTANCE Soluble forms of HIV-1 envelope trimers exhibit conforma
222 cleaved with PreScission protease to release soluble forms of proteins that can be optionally biotiny
225 y was to determine circulating levels of the soluble forms of RAGE in periodontitis and to evaluate t
228 binding to macrophage cell line, as well as soluble forms of recombinant mouse CD36, SR-A, and LOX-1
230 ies are consistent with data generated using soluble forms of the chloroplast chaperone receptors, OE
231 and tightly bound soluble WT-hSOD1, whereas soluble forms of the Cu-V103Z and L126Z variants demonst
234 cysteine residues have been introduced into soluble forms of the flexible envelope proteins in an at
238 (IL-6) is coordinated by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes
241 phenotype and fail to respond efficiently to soluble forms of the optimized immunogen, unless it is h
242 yme-linked immunosorbent assay (ELISA) using soluble forms of the prefusion and postfusion forms of t
243 in gB, possibly due to the use of different soluble forms of the protein and different assays for an
244 ular membranes, most studies have focused on soluble forms of the protein lacking both the membrane-a
245 ugh it is unclear whether aggregates or more soluble forms of the protein represent the pathogenic sp
246 refolding were not successful in generating soluble forms of the protein that contained well-ordered
249 antibodies against the viral S-protein, and soluble forms of the receptor for the virus, angiotensin
251 n invested in the engineering of recombinant soluble forms of the virion-associated Env trimer as vac
253 odels of sepsis, exogenous administration of soluble forms of TREM-1 attenuates inflammation and mark
257 y, we demonstrated that filamentous, but not soluble, forms of wild-type tau inhibit anterograde, kin
258 sess functional roles of substrate-bound and soluble-forms of the protein during VM DA development.
259 ify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor
262 the hypothesis that toxicity is exerted by a soluble form rather than an insoluble fibrillar form.
265 activates membrane-bound FasL and releases a soluble form reported to have both antagonist and agonis
266 yo-tomography and the x-ray structure of the soluble form reveals the detailed mechanisms by which th
267 rian cancer (EOC) cells and is released in a soluble form (sALCAM) by ADAM-17-mediated shedding.
272 of immunoregulatory peptides and through its soluble form (sDPP4) that directly engages immune cells.
273 eport that fibrils polymerized in vitro from soluble forms sequester toxic species that can be releas
275 (IL-6) membrane receptor and its circulating soluble form, sIL-6R, can be targeted by antibody therap
276 Falpha, TGFalpha, and c-Met receptor (or its soluble form, sMet) were evaluated using ELISA and quant
277 Nix/Bnip3L (Nix) and its alternately spliced soluble form (sNix) in hearts, but relative sNix/Nix exp
279 ngly, the SORLA ectodomain is cleaved into a soluble form, sSORLA, which has been shown to regulate c
280 o undergoes ectodomain shedding to release a soluble form (sTbetaRIII) that can bind ligand, sequeste
281 increases in TREM-2 levels are found as the soluble form (sTREM-2) long after clearance of infection
283 leukocyte recruitment to the liver, and the soluble form (sVAP-1) accounts for most circulating mono
286 press cell surface IL-13Ralpha2 but lack the soluble form that regulates IL-13 responses in mice.
287 ernative conformations in Escherichia coli-a soluble form that terminated transcription efficiently a
288 YC492, has been shown to exist in two forms: soluble forms that are believed to be toxic to the bacte
291 When this domain switches from its normal soluble form to an insoluble amyloid, the ensuing change
292 otein, called gp140, has also been made as a soluble form to mimic the native Env present on the viri
293 induces neuronal dysfunction and death in a soluble form; toxicity of the fragment is buffered by it
294 h convert transmembrane fractalkine into the soluble form, was significantly increased in these cases
298 hly express SECTM1, including an N-terminal, soluble form, which can be detected in the sera of metas
299 mer and found to be an active ATPase both in soluble form with detergent and when reconstituted into