ライフサイエンスコーパス: solve @2 structure

1 by high-resolution mass spectrometry data to solve its structure.

2 new multidimensional chemical approaches to solve RNA structures.

3 , we crystallized an LPL-GPIHBP1 complex and solved its structure.

4 to guide quantum mechanical calculations to solve the TS structure.

5 based on separate modeling using previously solved crystal structures.

6 h motion may therefore affect the process of solving crystal structures.

7 f sufficiently high resolution with which to solve the crystal structure.

8 iated genes using over 14,000 experimentally solved human protein structures.

9 tive positions is not always enough to fully solve a supramolecular structure.

10 onstruct three-dimensional (3D) lattices for solving macromolecular structures.

11 nsp12-RdRp structure and superimposed it on solved picornaviral RdRp structures.

12 a benchmark of large protein complexes with solved three-dimensional structures.

13 re domain of RVFV NSs (residues 83-248), and solved its crystal structure, a novel all-helical fold o

14 prediction both on epitope data derived from solved 3D structures, and on a large collection of linea

15 eltaE-LULL1 interaction, which enabled us to solve its structure at 1.4 A also.

16 strate preference of the Sicarius enzyme, we solved its crystal structure at 2.1 A resolution.

17 e crystallized EapH1 bound to this protease, solved the structure at 1.6 angstrom resolution, and ref

18 very similar in structure to the previously solved Nipah-N structure, but with a difference in the a

19 We solve its 3D structure by NMR and x-ray crystallography

20 express Lily in Schneider 2 insect cells and solve its structure by X-ray crystallography at 3.5 A re

21 lection method that uses a single crystal to solve X-ray structures by native SAD (single-wavelength

22 containing a native alpha-satellite DNA and solved its structure by the cryo-electron microscopy (cr

23 the role of these two zinc fingers, we have solved their structure by NMR.

24 gement of the C-terminal CA domains and have solved their structure by using hybrid cryo-EM and tomog

25 Subsequently solved crystal structures confirmed binding modes predic

26 esence of manganese instead of magnesium and solved the structure de novo using the anomalous signal

27 Additionally, we solved a crystal structure for the apo form of AgmNAT wi

28 Using the recently solved cryo-EM structure for the Eag-family channel as a

29 enge that there are only a limited number of solved MP structures for training the deep learning mode

30 croscopy approach is generally applicable to solve ubiquitous structure-function problems in electroc

31 ling nanoparticles with atomic precision and solving their total structures have long been major drea

32 mic of the beta-hairpin from EC869 toxin and solved its structure in complex with cognate immunity pr

33 We have solved its structure in complex with the C-terminal pept

34 of proteins vitrified at high temperatures, solve 12 structures of an archaeal ketol-acid reductoiso

35 s to a domain of 10 amino acids in TRPM3 and solve a cocrystal structure of this domain together with

36 To aid drug discovery efforts, here we solve a structure of CCR2 in a ternary complex with an o

37 Here, we solve a structure of Saccharomyces cerevisiae Pol I-CF-D

38 esults also suggest that it is preferable to solve cryo-EM structures of protein complexes at functio

39 ing thermophilic cyanobacterial homologs, we solve crystal structures of GAPDH with different cofacto

40 We solve crystal structures of LasR ligand-binding domains

41 l lysate is required as starting material to solve the atomic structure of the untagged, endogenous h

42 e used cryo-electron microscopy (cryo-EM) to solve the atomic structures of two filamentous double-st

43 Here we apply this method to solve the crystal structure of a 966-amino acid construc

44 Here we solve the crystal structure of a ternary complex compris

45 We solve the crystal structure of CxD7L1 in complex with AD

46 gth NiV phosphoprotein is tetrameric, and we solve the crystal structure of its tetramerization domai

47 We solve the crystal structure of ligelizumab bound to IgE,

48 Here, we solve the crystal structure of MlaC in its phospholipid-

49 We solve the crystal structure of the human ASPP2/PP1 compl

50 We solve the crystal structure of the LZ:CM2 complex, revea

51 Furthermore, we solve the crystal structures of E. coli PBP1b bound to m

52 Here we solve the crystal structures of the N-terminal domains o

53 Here we solve the crystal structures of the: (1) PF4 tetramer/fo

54 nvene to form a F(-)-selective pore, here we solve the crystal structures of two bacterial Fluc homol

55 Here we solve the dimer structures of wild-type APPTM (AAPTM WT)

56 We solve the NMR structure of its transmembrane domain in m

57 Here we solve the solution structure of the RNF126 zinc finger d

58 ning light and heavy elements, and use it to solve the structure of a beam-sensitive carbon nanostruc

59 We further solve the structure of a related enzyme, hydroxyethylpho

60 Here, we use NMR experimental constraints to solve the structure of a type-2 diabetes related human i

61 cryo-EM single-particle 3D reconstruction to solve the structure of CMG in complex with a DNA fork.

62 overy of the first known CntA inhibitors and solve the structure of CntA in complex with the inhibito

63 Here we solve the structure of HglS to 1.1 angstrom resolution i

64 Here, we solve the structure of hRpn13 with a segment of hRpn2 th

65 Here we unambiguously solve the structure of molybdenum disulfide monolayers u

66 ics of SCD function, here we crystallize and solve the structure of mouse SCD1 bound to stearoyl-CoA

67 We solve the structure of one of these conformers by cryo e

68 We solve the structure of the complex formed by an improved

69 We also solve the structure of the Drosophila Sas-6 N-terminal d

70 high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD compl

71 Here, we solve the structure of the TR LysG of Corynebacterium gl

72 We also solve the structure of this complex by negative stain el

73 Here, we solve the structures of a natural AAV isolate complexed

74 Here we use cryo-electron microscopy to solve the structures of AMPA receptor-auxiliary subunit

75 ay free electron laser, which can be used to solve the structures of complex proteins via serial femt

76 ported by ab initio calculations are used to solve the structures of K(5)[Mo(3)O(4)F(9)].3H(2)O (1),

77 we use cryo-EM reconstruction techniques to solve the structures of the HPV16 capsid complexes using

78 understand substrate selection by ERAP1, we solved 2 crystal structures of the enzyme with bound tra

79 To analyze the interaction details, we solved a crystal structure of an sAC.bithionol complex.

80 c to particular HCV-infected individuals, we solved a crystal structure of the HCV E2 ectodomain in c

81 We solved a crystal structure of Z1 in a complex with DNA c

82 We solved a structure of SidJ-CaM in complex with AMP and f

83 We solved a structure of the toxin bound to a fragment of t

84 nds 3 and 8 was performed using the recently solved atomic structure of paclitaxel (Taxol)-bound huma

85 We solved co-crystal structures of both VRK1 and VRK2 bound

86 ionally active as allosteric modulators, and solved co-crystal structures of the prokaryote (Erwinia)

87 ding mode of LDI as compared with previously solved complex structures of related cereal type family

88 ur IWF structure agrees well with a recently solved cryo-EM structure of a CFTR IWF state.

89 To address this question, we solved cryo-EM structures of Msp1-substrate complexes at

90 We next solved cryo-EM structures of two Sso-KARI complexes, wit

91 We used the recently solved crystal structure of a highly conserved region of

92 Moreover, the recently solved crystal structure of AMPK has shed light both int

93 Subsequently, the solved crystal structure of Drosophila Orai (dOrai) subs

94 ely 30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin

95 Starting from the recently solved crystal structure of Hv1, we used structural mode

96 g cation-pi interactions, as revealed by the solved crystal structure of its complex with human BChE.

97 The solved crystal structure of PhiCpeT at 1.8-A resolution

98 The solved crystal structure of TtCE15A revealed features pr

99 dem (Xyn10C-XBD), which represents the first solved crystal structure of two contiguous CBM22 modules

100 Finally, we solved crystal structures of 14-3-3sigma bound to mono-

101 Here, we solved crystal structures of 70S ribosomes harboring 16S

102 We have solved crystal structures of a human Brf2-TBP complex bo

103 ects on Sirt6 and other Sirtuin isoforms and solved crystal structures of compound complexes with Sir

104 s into substrate binding and specificity, we solved crystal structures of MurU of Pseudomonas putida

105 To provide structural insight, we solved crystal structures of SART3 in the apo-form and i

106 We have solved crystal structures of seven AT-less type I PKS KS

107 The previously solved crystal structures of the AvrPto-Pto and AvrPtoB-

108 Here, we solved crystal structures of the human RECQ1 helicase in

109 I-binding domain of RavA, and the previously solved crystal structures of the individual components,

110 Here, we have solved crystal structures of the LysM/M23 family peptida

111 We solved crystal structures of the OLF domain of myocilin

112 derstand the mechanism of MVC activation, we solved crystal structures of TtDdl representing distinct

113 correlates of SARS-CoV-2 neutralization, we solved eight new structures of distinct COVID-19 human n

114 n conformations of virion-associated Env, we solved EM structures of an Env/CD4/CD4-induced antibody/

115 Interestingly, solved forkhead structures of members from the P subfami

116 n insight into this promutagenic process, we solved four ternary structures of polbeta with an incomi

117 To address this problem, we solved high-resolution structures of human TDG bound to

118 Taking advantage of the recently solved molecular structures of the fibrillar core of the

119 We solved multiple crystal structures of this mutant A1 and

120 ase AtxE2 from Asticcacaulis excentricus, we solved NMR structures of its substrates astexin-2 and as

121 We solved separate NMR structures of the IQ motif (residues

122 We solved ten structures of the Escherichia coli rhomboid p

123 Using cryo-electron microscopy, we solved the atomic structure of an apex bnAb, PGT145, in

124 ystallization so we instead crystallized and solved the atomic structure of its close homolog from Tr

125 Here, we solved the atomic structure of the CTD of gingipain B (R

126 n insight into inhibition of MPO by SPIN, we solved the cocrystal structure of SPIN bound to a recomb

127 deoxyguanosine binding riboswitches, we have solved the crystal structure of a 2'-dG-II aptamer domai

128 Using this construct, we solved the crystal structure of a mini-hSIRT1-STAC compl

129 Finally, we solved the crystal structure of a single EGF repeat cova

130 Herein, we solved the crystal structure of a typical 2-Cys peroxire

131 cular basis of this acceptor promiscuity, we solved the crystal structure of A. fumigatus Crh5 (AfCrh

132 We solved the crystal structure of A49 from VACV Western Re

133 We solved the crystal structure of AcaB at 2.9- angstrom re

134 Here, we have solved the crystal structure of an EBNA1 hexameric ring

135 provide an alternative model system, we have solved the crystal structure of CthEgtB from Chloracidob

136 Recently, we solved the crystal structure of DnaK in complex with ATP

137 We also solved the crystal structure of full-length KGA and pres

138 We solved the crystal structure of GpsB and the interaction

139 ing how COQ9 can perform these functions, we solved the crystal structure of Homo sapiens COQ9 at 2.4

140 We have solved the crystal structure of human TIPRL at 2.15 A re

141 Here, we have solved the crystal structure of HypD from the pathogen C

142 We solved the crystal structure of IN-RA-PH to a resolution

143 o understand the physical basis for this, we solved the crystal structure of JFH-1 NS3, revealing a n

144 rmined the solution structure of MOR, and we solved the crystal structure of MOR in complex with the

145 Furthermore, we purified zebrafish MTH1 and solved the crystal structure of MTH1 bound to its inhibi

146 We solved the crystal structure of nthiOppA in complex with

147 We have solved the crystal structure of OmoMYC and show that it

148 e the interface between PexRD54 and ATG8, we solved the crystal structure of potato ATG8CL in complex

149 We solved the crystal structure of PRORP2 (3.2A) revealing

150 To define that interaction, we solved the crystal structure of RBBP4 in complex with an

151 We have solved the crystal structure of TarM at 2.4 A resolution

152 We solved the crystal structure of the 6-HB formed by MT-WQ

153 We have solved the crystal structure of the BCAP TIG and find th

154 -subunits influence Nav channel function, we solved the crystal structure of the beta2 extracellular

155 We previously defined and solved the crystal structure of the C-terminal domain of

156 Spo0J from Helicobacter pylori (HpSpo0J) and solved the crystal structure of the C-terminal domain tr

157 They solved the crystal structure of the catalytic domain of

158 We have solved the crystal structure of the catalytic module of

159 We solved the crystal structure of the complex between an o

160 We solved the crystal structure of the conserved Drosophila

161 m higher-order oligomers in solution, and we solved the crystal structure of the core pUL7:pUL51 hete

162 We also solved the crystal structure of the covalent inhibitor i

163 We solved the crystal structure of the E2 for the small ubi

164 We solved the crystal structure of the human Dicer-TRBP int

165 asis for this functional differentiation, we solved the crystal structure of the Na(+)-driven membran

166 We solved the crystal structure of the PDZ domain of PTPN4

167 Recently, we have solved the crystal structure of the phosphatase domain o

168 We solved the crystal structure of the SLX4BTB dimer, ident

169 d SMAC, primarily on Lys(62) and Lys(191) We solved the crystal structure of the tetrameric form of S

170 Here, we solved the crystal structure of the tubulin-pironetin co

171 We solved the crystal structure of the tumor overexpressed

172 Further, we solved the crystal structure of the WFIKKN2 FSD to 1.39

173 Here, we solved the crystal structure of this C-terminal domain f

174 We solved the crystal structure of this intein, revealing s

175 We solved the crystal structure of this IRES bound to a bac

176 We solved the crystal structure of this peptide in complex

177 We solved the crystal structure of UbV.7.2 and rationalized

178 We have now solved the crystal structure of VP90(71-415) (amino acid

179 We have solved the crystal structure of VP90(71-415) of human as

180 Here, we solved the crystal structures of AtPRF3Delta22 and AtPRF

181 s of this protease-substrate coevolution, we solved the crystal structures of drug resistant I50V/A71

182 lar mechanism of substrate cleavage, we have solved the crystal structures of human GGT1 (hGGT1) with

183 gin of fluorescence in these phytofluors, we solved the crystal structures of IFP1.4 and a comparison

184 e with histone chaperoning activity, we have solved the crystal structures of its terminal domains an

185 We solved the crystal structures of mAb HENV-26 in complex

186 We solved the crystal structures of the AIPL1-FKBP domain a

187 We have solved the crystal structures of the apo and L-arabinose

188 for dCTP incorporation opposite dG(1,8), we solved the crystal structures of the complexes of Dpo4 a

189 Second, we solved the crystal structures of the GII.13 P dimers in

190 Furthermore, we solved the crystal structures of the GLR3.3 LBD in compl

191 bases behind these evolutionary changes, we solved the crystal structures of the HBGA binding protru

192 In this study, we solved the crystal structures of the HRP3 PWWP domain in

193 tigate these different FHA binding modes, we solved the crystal structures of the mycobacterial upstr

194 We have solved the crystal structures of the NTD core and EXO do

195 We then solved the crystal structures of the wild-type mIDH2 and

196 We have solved the crystal structures of wild-type AdiC in the p

197 We also solved the crystal structures of WT and N53I CaM in comp

198 inhibitor, we used X-ray crystallography and solved the first structure of a Nedd4-1 family ligase bo

199 Here we have solved the first structure of a T3SS-associated PG-lytic

200 Recently, we solved the functional structure of AID and demonstrated

201 Here, we solved the solution structure of C. diphtheriae MsrB (Cd

202 We solved the solution structures of the RRM in complex wit

203 We solved the structure of a malate racemase apoprotein and

204 Here, we solved the structure of a newly identified TCR in comple

205 Here we solved the structure of a non-peptide agonist, TT-OAD2,

206 We have solved the structure of a potent TRIM21-dependent neutra

207 We solved the structure of an A55BB/Cul3-NTD complex from a

208 and the basis for BRCC36 regulation, we have solved the structure of an active BRCC36-KIAA0157 hetero

209 We solved the structure of Bal6GBP in complex with beta-(1,

210 uide the design of improved therapeutics, we solved the structure of CCR5 in complex with chemokine a

211 In the current study, we solved the structure of DbpA from B. burgdorferi strain

212 We solved the structure of Dfg5 from a filamentous fungus a

213 We also solved the structure of FIPV M(pro) complexed with two i

214 Here, we have solved the structure of human helicase DHX15/Prp43, whic

215 We solved the structure of MKP5 in complex with this inhibi

216 Using solid-state NMR, we solved the structure of P1 bound to PC/Chol and compared

217 To overcome heterogeneity, we solved the structure of P405M-HlyIIC, a mutant that excl

218 single particle cryo-electron microscopy, we solved the structure of Pf20S in complex with one and tw

219 We previously solved the structure of RS1, a 16-mer composed of paired

220 Finally, we solved the structure of RU.521 bound in two alternate al

221 We solved the structure of SIRT1 in complex with resveratro

222 Here we have solved the structure of smooth muscle 10S myosin by cryo

223 We have solved the structure of the 14.1Fab fragment in complex

224 We also solved the structure of the [4Fe-4S] cluster-bound, engi

225 We solved the structure of the CAK complex from the model o

226 lipoprotein-binding protein 1 (GPIHBP1) and solved the structure of the complex.

227 ron microscopy and helical reconstruction we solved the structure of the crenactin filament to 3.8 A

228 We have solved the structure of the HR1 domain of TOCA1, providi

229 Additionally, we solved the structure of the human LRH-1 DNA-binding doma

230 engineering with a novel fusion chimaera, we solved the structure of the human OX2R bound to suvorexa

231 Using x-ray crystallography, we solved the structure of the human SUMO E1 ubiquitin fold

232 We further solved the structure of the MastR-T74D mutant, which con

233 We solved the structure of the MPE8 antibody bound to RSV F

234 ively dysregulate parasite PKA signaling, we solved the structure of the PKA regulatory subunit in co

235 f electron cryo-microscopy (cryoEM), we have solved the structure of the Pyrococcus furiosus archaell

236 We solved the structure of the SMU1 N-terminal domain in co

237 We have solved the structure of the yeast mitoribosomal large su

238 We solved the structure of ThiL from the human pathogen A.

239 We characterized four of these hits and solved the structure of two, the GUSs from Ruminococcus

240 Using the reported methods we solved the structures of (i) Pseudorabies virus (PRV) RN

241 We solved the structures of 11 real-life examples, includin

242 the structural basis of this phenomenon, we solved the structures of ELIC embedded in palmitoyl-oleo

243 We solved the structures of individual colloidal platinum n

244 ions of the MBD2-NuRD complex, we previously solved the structures of MBD2 bound to methylated DNA an

245 Next, we solved the structures of recombinant 20beta-HSDH in both

246 We have solved the structures of the Thermus thermophilus 70S ri

247 We also solved the structures of three bisamidines binding to DN

248 In this study, we solved the structures of three different FabI homologues

249 We solved the structures of two 15-mer epitopes in complex

250 xplain the catalytic mechanism of VvAHGD, we solved the structures of VvAHGD in the apo form and comp

251 To address this issue, here we first solved three crystal structures of the IRAK4 kinase doma

252 We solved three crystal structures of this TdT chimera boun

253 We solved two crystal structures of the Nostoc sp. PCC 7120

254 We used a recently solved X-ray structure of the orexin receptor subtype 2

255 We solved X-ray structures of all three FimA monomers at 0.

256 In this study, we used solved x-ray structures of inhibitor-bound PDEdelta targ

257 de rationalization of the mode of binding by solving co-crystal structures of selected inhibitors in

258 Here we demonstrate the feasibility of solving cryo-EM structures of proteins vitrified at high

259 athway of a photoswitchable GFP, rsEGFP2, by solving crystal structures of cis and trans rsEGFP2 cont

260 By solving crystal structures of maltose binding protein (M

261 By solving solution NMR structures of selected macrocycles

262 utralization mechanisms were demonstrated by solving the atomic structure of a NAb-RBD complex, throu

263 By solving the crystal structure of a clinical ST258 OmpK36

264 ystal X-ray diffraction measurements allowed solving the crystal structure of a host-guest adsorbate,

265 By solving the crystal structure of human AlaRS and compari

266 Unexpectedly, solving the crystal structure of Tda2 revealed it belong

267 d the molecular basis for this inhibition by solving the crystal structure of the complex and simulat

268 Solving the crystal structure of the DEKK Fc region at a

269 By solving the crystal structure of the Hook domain and usi

270 By solving the crystal structure of the IL-1alpha/aptamer,

271 By solving the crystal structure of the paromomycin-ribosom

272 eractive quaternary surface is delineated by solving the crystal structure of two FR3 loop-chimeric a

273 By solving the crystal structures of Btk inhibitors bound t

274 By solving the crystal structures of the glycan ligand bind

275 We confirmed this by solving the structure of Bsg25A complexed to the Insv si

276 determinants of helical template assembly by solving the structure of the CARD9 filament.

277 e acylbenzene derivative 10 was validated by solving the structure of the complex with the CREBBP bro

278 By solving the structure of the OTU domain in complex with

279 By solving the structure of the protease domain bound to a

280 By solving the structure of the virus, and through sequence

281 e how hRpn10 binds to the UBQLN2 UBL domain, solving the structure of this complex by NMR, and determ

282 Furthermore, a general technical approach to solving the structures of small molecules is demonstrate

283 Solving the structures of unphosphorylated IRAK4 in comp

284 s work presents a promising strategy towards solving the protein structure prediction problem.

285 -Sham scheme of density functional theory to solve electronic structure problems in a wide variety of

286 Solving its crystal structure revealed almost perfect al

287 ecular findings, modeling of the variants on solved protein structures showed distinct spatial cluste

288 s demonstrate that DNCs have the capacity to solve complex, structured tasks that are inaccessible to

289 Along with the previously solved NgTet1-5mC structure, the two complexes offer a d

290 s postvittana (EposPBP3), and experimentally solved its apo-structure through X-ray crystallography t

291 rosophila Ana2 CCCD forms a tetramer, and we solve its structure to 0.8 A, revealing that it adopts a

292 ed FlhE from the periplasm of Salmonella and solved its structure to 1.5A resolution.

293 ional helical turn between junctions, and we solved the structure to 4.5 angstrom resolution by molec

294 n center and visualized its diiron center by solving its crystal structure to 3.5 angstrom.

295 Using multiple recently solved cryo-EM structures, we show that observed cross-l

296 cysteine carboxyl methyltransferases with a solved crystal structure, we identified amino acids crit

297 In addition to solving the crystal structure, we found that apart from

298 mode method for systematically exploring and solving such structures which will be widely applicable

299 bitor, we developed a more potent analog and solved a cocrystal structure, which is the first crystal

300 Structure-based design was guided by several solved cocrystal structures with Mcl-1, leading to the d