ライフサイエンスコーパス: somatic cell

1 s in embryonic stem cells (ESCs) compared to somatic cells.

2 e development and communication with ovarian somatic cells.

3 surrounding, diverse, and changing layers of somatic cells.

4 were critical for regulating its promoter in somatic cells.

5 es not alter gene expression in a variety of somatic cells.

6 telomerase gene (hTERT) is repressed in most somatic cells.

7 sion during meiosis, which is different from somatic cells.

8 s, including oocyte and six types of ovarian somatic cells.

9 tion complexes similar to those described in somatic cells.

10 ontain more genomic variations than cultured somatic cells.

11 expressed in human fetal germ cells than in somatic cells.

12 otein at only 6% the level of their adjacent somatic cells.

13 d metabolism that differs from untransformed somatic cells.

14 (H1.10 and H1.0) subtypes, all expressed in somatic cells.

15 epended on KAP1 in both mouse ESCs and human somatic cells.

16 xpansion of the repeat tract in germline and somatic cells.

17 are tolerated or how they are propagated in somatic cells.

18 otential role of OCT4 in normal and diseased somatic cells.

19 hanced reprogramming in both mouse and human somatic cells.

20 tes from other readily and safely accessible somatic cells.

21 r cell-autonomous de novo DNA methylation in somatic cells.

22 rs that control the functions of surrounding somatic cells.

23 hway to maintain the male identity of testis somatic cells.

24 elomerase activity is silenced in most adult somatic cells.

25 , but little is known about its functions in somatic cells.

26 ccessory protein DNMT3L to recruit DNMT3A in somatic cells.

27 of permanent variation of gene expression in somatic cells.

28 n formation and silencing in human and mouse somatic cells.

29 aining the spermatogonial stem cell niche in somatic cells.

30 ted by Notch2 signaling from the neighboring somatic cells.

31 that its translation is under the control of somatic cells.

32 ichment on the inactive X chromosome (Xi) in somatic cells.

33 hylation during embryonic development and in somatic cells.

34 ctory to mutation accumulation compared with somatic cells.

35 come a popular method to detect selection in somatic cells.

36 omosomes following DNA elimination breaks in somatic cells.

37 pecific - EGO-1 in the germline and RRF-1 in somatic cells.

38 normally silenced by DNA methylation in most somatic cells.

39 thetase alters programming and plasticity of somatic cells.

40 nduced pluripotent stem cell generation from somatic cells.

41 genes, with some genes even escaping XCI in somatic cells.

42 at LINE-1 activity is present in many normal somatic cells.

43 wn as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells.

44 ociated and co-differentiate with supporting somatic cells.

45 nsitions are coordinated by RA from Sertoli (somatic) cells.

46 s marked by H3K4me3 in actively transcribing somatic cells(7).

47 splicing of Gypsy mRNAs in cultured ovarian somatic cells, a process required for the production of

48 Deleting TRF2 (also known as TERF2) in somatic cells abolishes T-loop formation, which coincide

49 Somatic cells acquire mutations throughout the course of

50 or inducing lineage-specific stem cells from somatic cells across lineage boundaries have been challe

51 These studies provide insights into ovarian somatic cells and a resource to study the development, p

52 egulated loci is preserved in differentiated somatic cells and can occur in the absence of exogenous

53 ntral process to ensure genomic stability in somatic cells and during meiosis.

54 ost organisms consist of two cell lineages - somatic cells and germ cells.

55 Mutations accumulate within somatic cells and have been proposed to contribute to ag

56 developmental gene loci differ between human somatic cells and hPSCs, and that changes in the chromat

57 In conclusion, changes in milk somatic cells and milk metabolomics indicated that heat

58 antisense deoxyoligonucleotide (dO) into the somatic cells and reduces the cognate mRNA levels.

59 nsplantation of PGCs aggregated with gonadal somatic cells and showed that reconstituted ovaries exhi

60 stricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes

61 in Drosophila, where homologs are paired in somatic cells and transvection is prevalent.

62 events the death of cultured RPL10-deficient somatic cells, and Rpl10l-promoter-driven transgenic exp

63 evidence that OCT4 has a functional role in somatic cells, and they highlight the potential role of

64 n ALADIN participates in spindle assembly in somatic cells, and we have also shown that female mice h

65 ts known to express germ-line genes in their somatic cells are long-lived.

66 All normal somatic cells are thought to acquire mutations, but unde

67 Genotyping of somatic cells as well as brain biopsies confirmed mutati

68 l growth, survival, and metastasis, but also somatic cell behaviour.

69 In somatic cells, BRCA2 is needed for RAD51-mediated homolo

70 are generally transcriptionally repressed in somatic cells but can be robustly induced upon infection

71 Thus, Rcd4 is essential in somatic cells but is not absolutely required in spermato

72 t to induce a male identity in adult ovarian somatic cells, but it acts through a Dsx(M)-independent

73 on, p53 regulation and cell proliferation in somatic cells, but its role in embryonic stem cells is u

74 n maintenance are similar between pollen and somatic cells, but the efficiency of CG methylation is h

75 in immune cells which can also be induced in somatic cells by cytokines such as TNF-alpha or IFN-gamm

76 induced pluripotent stem cells (iPSCs) from somatic cells by OCT4, SOX2, KLF4, and MYC (OSKM) transd

77 c cells suggests that the sexual identity of somatic cells can be reprogrammed in the adult Drosophil

78 rovides in vivo evidence that differentiated somatic cells can be reprogrammed into cancer initiating

79 Somatic cells can be successfully reprogrammed into plur

80 Our somatic cells can provide fitness benefits that exceed t

81 L1 retrotransposition can also occur in somatic cells, causing genomic mosaicism, as well as in

82 In cycling somatic cells, centromere identity is maintained by an e

83 tor contributing to developmental failure in somatic cell cloned embryos.

84 >50-fold "shotgun" cellular coverage of its somatic cell composition.

85 erstanding of phenotypic plasticity in adult somatic cells comprises dedifferentiation and transdiffe

86 ed daily and milk samples were collected for somatic cell count (SCC) and colony forming units (CFU).

87 Mammary quarter milk somatic cell count (SCC) and N-acetyl-beta-d-gluconamini

88 es from cows in early lactation or with high somatic cell count, the root mean square error of predic

89 in early lactation and in samples with high somatic cell count.

90 -blastula transition (MBT) when asynchronous somatic cell cycles start.

91 nknown whether electrophysiologically-active somatic cells derived from separate germ layers can be i

92 for those investigating testicular germ and somatic cell developmental during the perinatal period.

93 ore sex determination and most genital ridge somatic cells differentiated into steroidogenic cells in

94 he expression of Sf1 was upregulated and the somatic cells differentiated into steroidogenic cells in

95 Our study uncovers a novel mechanism of somatic cell differentiation during gonad development.

96 hat both BMP2 and E2 action is essential for somatic cell differentiation for PF formation.

97 pluripotent stem cells can be converted, or somatic cells directly reprogrammed, to EPSCs that displ

98 Somatic cells dissociated from an adult sponge can reorg

99 far more essential for this process than for somatic cell divisions.

100 ion and intra-loop structures but, unlike in somatic cells, does not increase loop size.

101 nuppy, the world's first cloned dog, and its somatic cell donor, Tai, a male Afghan hound.

102 metazoa, DNA elimination typically occurs in somatic cells during early development, leaving the germ

103 f ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice.

104 e activity eliminates H4K20me1 enrichment in somatic cells, elevates X-linked gene expression, reduce

105 ed to investigate the kinematic behaviour of somatic cells emerging from hESC differentiation and to

106 Cell, Pae et al. (2017) show that GCL blocks somatic cell fate by specifically destroying the Torso R

107 mp signalling cues regulate germ cell versus somatic cell fate decisions in the early posterior epibl

108 rosine kinase (RTK) and major determinant of somatic cell fate.

109 re required for commitment to differentiated somatic cell fates.

110 are exposed to numerous signals that specify somatic cell fates.

111 ent with their contributions to germline and somatic cell fates.

112 ent models of a single genetic disease using somatic cells from a common patient will facilitate the

113 uki (2017) describe the direct conversion of somatic cells from both mice and humans into robust inte

114 , where homologous chromosomes are paired in somatic cells from embryogenesis through adulthood.

115 te islands during the reprogramming of human somatic cells from skin biopsies and blood draws obtaine

116 t possess normal testicular architecture and somatic cell function capable of supporting allogeneic d

117 Somatic cell fusion and conspecific cooperation are cruc

118 ition mechanisms in syncytial fungi regulate somatic cell fusion by operating precontact during chemo

119 ty and regulate cell wall dissolution during somatic cell fusion in a wild population of the filament

120 ition of multicellularity is associated with somatic cell fusion within and between colonies.

121 ction, enveloped virus entry into cells, and somatic cell fusion.

122 elegans Epithelial Fusion Failure 1 (EFF-1) somatic cell fusogen can replace HAP2/GCS1 in one of the

123 Mutations in somatic cells generate a heterogeneous genomic populatio

124 e mark transmits faithfully across mammalian somatic cell generations.

125 inserting L1 sequences into new locations of somatic cell genomes.

126 al model of L1 transcriptional activation in somatic cells, governed by individual-, locus-, and cell

127 Direct reprogramming of somatic cells has been demonstrated, however, it is unkn

128 etabolic interactions between the oocyte and somatic cells has been limited due to dynamic nature of

129 Phenotypic plasticity of adult somatic cells has provided emerging avenues for the deve

130 Previous studies in somatic cells have shown that midzone MTs become highly

131 VASA and SYCP3 induced direct conversion of somatic cells (hFSK (46, XY), and hMSC (46, XY)) into a

132 RDM15 is largely dispensable for mouse adult somatic cell homeostasis in vivo, it plays a critical ro

133 We thus now propose that, in somatic cells, homologous dsDNA-dsDNA interactions betwe

134 Selection between somatic cells (i.e., intercellular competition) can dela

135 We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche

136 stence of somatic mutations in a fraction of somatic cells in a single biological sample.

137 mic epithelium (CE) give rise to most of the somatic cells in both XX and XY gonads.

138 Homologous chromosomes pair in somatic cells in Drosophila, but how this occurs is poor

139 The recruitment of somatic cells in milk after LPS treatment was delayed by

140 fundamentally different from differentiated somatic cells in their innate immunity, which may have i

141 al genes, partially reprogramming long-lived somatic cells in vivo to a primitive, fetal-like, and pr

142 s that acquisition of a germ-cell program in somatic cells increases lifespan and contributes to daf-

143 ption-factor-mediated reprogramming of human somatic cells, indicate a role for the trophectoderm-lin

144 show that CSMD1 is enriched at the germ-cell/somatic-cell interface in both male and female gonads.

145 Lineage reprogramming of adult somatic cells into iCPCs provides a scalable cell source

146 OCT4, SOX2, KLF4, and cMYC (OSKM) reprograms somatic cells into induced pluripotent stem cells (iPSCs

147 The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs

148 , and facilitate the direct reprogramming of somatic cells into induced trophoblast stem cells.

149 Direct conversion of somatic cells into neurons holds great promise for regen

150 ion factor expression can transdifferentiate somatic cells into other specialised cell types or repro

151 network is a critical event in reprogramming somatic cells into pluripotent status.

152 t cell reprogramming, the process by which a somatic cell is converted to another cell type, can pote

153 The primary goal of a dividing somatic cell is to accurately and equally segregate its

154 Acquisition of pluripotency by somatic cells is a striking process that enables multice

155 unication between the oocyte and surrounding somatic cells is critical for the normal development of

156 study suggests that transcription of DUX4 in somatic cells is modified by variations in its epigeneti

157 wever, the role of PRC2 in lineage-committed somatic cells is mostly unknown.

158 TERT) gene, which remains repressed in adult somatic cells, is critical during tumorigenesis.

159 To understand the impact of transposition in somatic cells it is essential to reliably measure the fr

160 Normal mammalian somatic cells lacking KIF18A function complete cell divi

161 modify the epigenome in germ cells and fetal somatic cells leading to an increased susceptibility amo

162 referred mode of homologous recombination in somatic cells leading to an obligatory non-crossover out

163 nts multiple transposition bursts in a given somatic cell lineage that later contributes to different

164 naling in niche establishment by segregating somatic cell lineages for differentiation.

165 LHX9, and a loss of differentiated cells in somatic cell lineages.

166 differentiation of pluripotent stem cells to somatic cell lineages.

167 lymorphic L1HS-Ta copies in 12 commonly-used somatic cell lines, and identified transcriptional and e

168 evolutionary mechanisms in both germline and somatic cell lines.

169 also occurred following SmcHD1 knockout in a somatic cell model, but in this case, independent of Xi

170 This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and i

171 Plasma for fatty acid (FA) analysis and milk somatic cells (MSC) were obtained from all cows at the b

172 t, in contrast to what has been described in somatic cells, MTA proteins are not mutually exclusive w

173 nformation processing in non-neural metazoan somatic cell networks.

174 y different reprogramming approaches, either somatic cell nuclear transfer (NT-hESCs) or with defined

175 Somatic cell nuclear transfer (SCNT) can reprogram a som

176 fore investigated the role of miR-449b using somatic cell nuclear transfer (SCNT) embryo model.

177 amine the effects of electrofusion on rabbit somatic cell nuclear transfer (SCNT) embryos, and to tes

178 nresolved issue in the cloning of mammals by somatic cell nuclear transfer (SCNT) is the mechanism by

179 Somatic cell nuclear transfer (SCNT) provides an excelle

180 induced pluripotent stem cells, iPSCs) or by somatic cell nuclear transfer (SCNT).

181 ve been performed in cell lines, followed by somatic cell nuclear transfer cloning, which can be inef

182 into goat fetal fibroblast cells followed by somatic cell nuclear transfer for Tc goat production.

183 Somatic cell nuclear transfer has established that the o

184 D4(+)T cells expressing the same TCR as this somatic cell nuclear transfer nTreg model had a reduced

185 We used gene editing and somatic cell nuclear transfer to engineer porcine embryo

186 pecificity determines iNKT function, we used somatic cell nuclear transfer to generate three lines of

187 ow that iNKT transnuclear mice, generated by somatic cell nuclear transfer, have increased tissue res

188 Together with somatic cell nuclear transfer, iPSC generation reveals t

189 line and generated PERV-inactivated pigs via somatic cell nuclear transfer.

190 ackground using epigenetic reprogramming via somatic cell nuclear transfer.

191 ansient assembly of filamentous actin within somatic cell nuclei.

192 e could not detect P-granule proteins in the somatic cells of daf-2 mutants by immunostaining or by e

193 nical properties of the spheroids from human somatic cells of different phenotypes: mesenchymal stem

194 expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries.

195 ophis is expressed in somatic cells of male and female gonads, as well as in a

196 uced pluripotent stem cells (iPSCs) from the somatic cells of patients in combination with subsequent

197 Somatic cells of patients with TTS and control subjects

198 olve sex-specific molecular signals from the somatic cells of the developing gonads and a suite of in

199 r data reveal a role for bmm function in the somatic cells of the gonad and in neurons in the regulat

200 y an additional role for bmm function in the somatic cells of the gonad and in neurons in the regulat

201 a, MIH comprises neuropeptides released from somatic cells of the gonad.

202 id droplets are normally present in both the somatic cells of the male gonad and in neurons, revealin

203 s and gene-editing reagents are delivered to somatic cells of whole plants.

204 fter the induction of reprogramming in human somatic cells on day 7 from the 20-24 day process.

205 enumerate other specific cell types such as somatic cells or cells from tissue or liquid biopsies.

206 l types are directly reprogrammed from human somatic cells or differentiated from an iPSC intermediat

207 t the piRNA pathway may be present in select somatic cells outside the gonads, the role of a non-gona

208 A demethylation induced by XPC expression in somatic cells overcomes an early epigenetic barrier in c

209 In Drosophila ovarian somatic cells, PIWI-interacting small RNAs (piRNAs) agai

210 However, in some species and in human somatic cells, Piwil proteins bind primarily to tRNA.

211 (A)-binding protein (ePABP) or the canonical somatic cell poly(A)-binding protein PABPC1 for activati

212 's ratchet principle applied to the aging of somatic cell populations and discuss the implications fo

213 illustrates the sequential establishment of somatic cell populations during testis morphogenesis.

214 ination between the germline and supporting, somatic cell populations.

215 Here, we demonstrate that mature human somatic cells produce abundant virus-derived siRNAs co-i

216 TET inactivation increased the efficiency of somatic cell programming without affecting TET complexes

217 led by the observations that, in contrast to somatic cells, PSCs are programmed to die in response to

218 y is regulated in HD affected stem cells and somatic cells remains largely unclear.

219 egulated during embryonic development and in somatic cells remains largely unknown.

220 ast majority of tumor cells, but its role in somatic cells remains to be understood.

221 variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for can

222 drive cellular plasticity in the context of somatic cell reprogramming and tumorigenesis.

223 nscriptome, although its functional roles in somatic cell reprogramming are largely unexplored.

224 The signaling mechanisms controlling somatic cell reprogramming are not fully understood.

225 ects of RNA metabolism, the roles of RBPs in somatic cell reprogramming are poorly understood.

226 The MKL1-actin pathway weakens during somatic cell reprogramming by pluripotency transcription

227 r mitochondrial Akt1 signaling that enhanced somatic cell reprogramming efficiency.

228 Even though different methods of somatic cell reprogramming result in stem cell lines tha

229 s role in self-renewal, differentiation, and somatic cell reprogramming to pluripotency.

230 The role of mitochondrial Akt1 in somatic cell reprogramming was investigated by transduci

231 Finally, Rif1 acts as a barrier during somatic cell reprogramming, and its depletion significan

232 t that C35 is an important tool for inducing somatic cell reprogramming, as well as for dissecting th

233 In the context of somatic cell reprogramming, inhibition of ZNF398 abolish

234 the comprehension of the complex process of somatic cell reprogramming, many questions regarding the

235 ns and predicts experimental observations of somatic cell reprogramming.

236 argets of ectopically induced factors during somatic cell reprogramming.

237 ation along with active transcription during somatic cell reprogramming.

238 he enzymatic function of TET proteins during somatic cell reprogramming.

239 oxidation steps, examining their effects on somatic cell reprogramming.

240 hway, which may be responsible for promoting somatic cell reprogramming.

241 chondrial Akt1 signaling was required during somatic cell reprogramming.

242 iation and, conversely, acts as a barrier to somatic-cell reprogramming.

243 in-specific protease 26 negatively regulates somatic cell-reprogramming process by stabilizing chromo

244 How somatic cells restrict L1 activity and how this process

245 lack of telomerase expression in most human somatic cells results from its repressive genomic enviro

246 ns unclear how intercellular signaling among somatic cells results in only one cell in the sub-epider

247 lineage conversion, thereby reprogramming a somatic cell's identity.

248 to udder health, including milk yield (MY), somatic cell score (SCS), lactose (%, LACT), pH and non-

249 lls and oocytes, nurse cells, like embryonic somatic cells, silence genes in traditional Polycomb dom

250 ssed in immune cells (hemocytes) and ovarian somatic cells (stretched cells) during their brief phago

251 Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly

252 to promote a male identity in adult gonadal somatic cells suggests that the sexual identity of somat

253 arily conserved archaic embryonic program in somatic cells that can be de-repressed for oncogenesis.

254 cells (GSCs) surround the hub, a cluster of somatic cells that organize the stem-cell niche.

255 of interactions between oocytes and ovarian somatic cells that remain poorly understood.

256 In contrast to somatic cells, the first meiotic spindle assembles in th

257 In comparison to somatic cells, the oocyte transcriptome has a shorter po

258 In somatic cells, these functions are both mediated by Scc1

259 strates that miR-128 controls L1 activity in somatic cells through two independent mechanisms: direct

260 hful resetting of the epigenetic memory of a somatic cell to a pluripotent state during cellular repr

261 rs and microRNAs that directly reprogram one somatic cell to another.

262 ing embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells.

263 eggs can induce the nuclear reprogramming of somatic cells to enable production of cloned animals.

264 are aggregated with mouse embryonic ovarian somatic cells to form xenogeneic reconstituted ovaries,

265 re we describe a protocol to reprogram human somatic cells to hiPSCs with high efficiency in 15 d usi

266 Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs)

267 Examples are the conversion of somatic cells to induced pluripotent stem cells and reju

268 to hotspot codons 12 and 13 of Kras in adult somatic cells to initiate tumors in the lung, pancreas,

269 hereas it functions non-cell-autonomously in somatic cells to maintain spermatogonial stemness.

270 he fitness cost of producing nonreproductive somatic cells to outweigh any potential benefits.

271 torial code was initially found to reprogram somatic cells to pluripotency, a "second generation" of

272 n factor expression enables reprogramming of somatic cells to pluripotency, albeit with generally low

273 DNA methylation during the reprogramming of somatic cells to pluripotency.

274 Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency.

275 factors, as is exemplified by reprogramming somatic cells to pluripotent stem cells through the expr

276 The reprogramming of human somatic cells to primed or naive induced pluripotent ste

277 The inherent capacity of somatic cells to switch their phenotypic status in respo

278 actors can directly reprogram differentiated somatic cells to target cell types.

279 a single TF alters multi-loop hubs to drive somatic cell trans-differentiation.

280 In somatic cells, transcription of L1 elements is repressed

281 ental signaling pathways can generate mature somatic cell types for basic laboratory studies or regen

282 Leydig and theca-interstitium) are two major somatic cell types in mammalian gonads, but the mechanis

283 transcriptional signatures of major germ and somatic cell types of the testes in human, macaque, and

284 have the potential to differentiate into all somatic cell types, have become the emerging source of a

285 ansgene expression in multiple primary human somatic cell types, thereby representing a highly attrac

286 ency of reprogramming across a wide range of somatic cell types.

287 ge germ cell development and enrich for rare somatic cell-types and spermatogonia.

288 many quality control mechanisms operating in somatic cells undergoing growth.

289 ATM loss leads to a mild HDR defect in adult somatic cells, we find that ATM inhibition leads to seve

290 Here, using Xenopus egg extracts and human somatic cells, we show that actin dynamics and formins a

291 While DNA damage and subsequent mutation in somatic cells were first proposed as drivers of aging mo

292 trary to Dmc1, Rdh54/Tid1 is also present in somatic cells where its function is less understood.

293 Unlike in somatic cells, where the APC/C first targets cyclin A2 f

294 nscriptase (hTERT) gene is repressed in most somatic cells, whereas the expression of the mouse mTert

295 rs can selectively kill cancer cells but not somatic cells, which retain both alleles.

296 ively measure LINE-1 activity across healthy somatic cells, while backing out the effect of pervasive

297 the biological impact of mobile elements in somatic cells will be greatly facilitated by the use of

298 m cells (ESCs) differs markedly from that in somatic cells, with ESCs exhibiting a more open chromati

299 directly from fewer than 1,000 primary human somatic cells, without requiring stable genetic manipula

300 embryos, is conditionally deleted from Xi in somatic cells (Xi(Xist)).