ライフサイエンスコーパス: somatic stem cell

1 e almost no data on protein synthesis in any somatic stem cell.

2 g germline stem cells that are distinct from somatic stem cells.

3 signaling can promote self-renewal of adult somatic stem cells.

4 ifelong self-renewal is a unique property of somatic stem cells.

5 ransdifferentiation events between different somatic stem cells.

6 mall populations of observable germ-line and somatic stem cells.

7 egulation of stemness and differentiation of somatic stem cells.

8 tasis requires long-term lineage fidelity of somatic stem cells.

9 mesenchymal (MSCs) and hematopoietic (HSCs) somatic stem cells.

10 ng been postulated to impair the function of somatic stem cells.

11 rs responsible for pluripotency induction in somatic stem cells.

12 n neural stem cells that also apply to other somatic stem cells.

13 little is known about shelterin functions in somatic stem cells.

14 ce and for regulating the differentiation of somatic stem cells.

15 for maintenance of the resident germline and somatic stem cells.

16 ral solid cancers share characteristics with somatic stem cells.

17 transplantation of both human embryonic and somatic stem cells.

18 (Gef26) results in loss of both germline and somatic stem cells.

19 like previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intes

20 ing tissue homeostasis by dynamic control of somatic stem cell activity.

21 Even tissues endowed with somatic stem cells age while the germline appears immort

22 racing, we demonstrate the existence of such somatic stem cells and confirm that of germ-line stem ce

23 CIs express markers associated with germ and somatic stem cells and gene products that implicate CIs

24 ood circulation, there exists an exchange of somatic stem cells and germline stem cells, resulting in

25 GSCs, yet maintained a normal population of somatic stem cells and hub cells.

26 s bone loss through activation of endogenous somatic stem cells and inhibition of inflammatory T-cell

27 Planarian neoblasts are pluripotent, adult somatic stem cells and lineage-primed progenitors that a

28 rom a replicative decline in the function of somatic stem cells and other self-renewing cells.

29 rs can cause permanent epigenetic changes in somatic stem cells and that these accumulate over the li

30 dicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved proces

31 criptional program that controls the fate of somatic stem cells and the regenerative responses of cer

32 In contrast to the skin and the gut, where somatic stem cells and their niche are well characterize

33 een implicated in both normal (embryonic and somatic) stem cells and CSCs.

34 ress can drive a rapid and permanent loss of somatic stem cells, and illustrates an example in which

35 is expressed at the cell surface of multiple somatic stem cells, and it is widely used as a cell surf

36 anscripts are enriched in ES cells and other somatic stem cells, and its ortholog is essential for he

37 l cord injuries with therapeutically plastic somatic stem cells, and suggest that neural stem/precurs

38 issue in stem cell biology is whether adult somatic stem cells are capable of accessing alternate ti

39 In the Drosophila testis, germline and somatic stem cells are housed together in a common niche

40 sing differentiation, whereas the dom mutant somatic stem cells are lost because of defective self-re

41 When unperturbed, somatic stem cells are poised to affect immediate tissue

42 , metastasis, and drug resistance, and, like somatic stem cells, are thought to be capable of unlimit

43 lained by the pervasive use of glycolysis by somatic stem cells as opposed to the predominance of mit

44 n requires the normal hedgehog signal of the somatic stem cells as well as proximity to the niche.

45 itical homeostatic processes in germline and somatic stem cells, as well as regenerative processes in

46 ing system, we found that both germ-line and somatic stem cells, as well as their progeny, adjust the

47 In Drosophila testes, germ line and somatic stem cells attach to a cluster of support cells

48 As DNA variants accumulate in somatic stem cells, become selected or evolve neutrally,

49 in has yet been functionally linked to adult/somatic stem cell behavior in vivo or to organ regenerat

50 repair plays a crucial role in embryonic and somatic stem cell biology and cell reprogramming.

51 describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing

52 In planarians, pluripotent somatic stem cells called neoblasts supply new cells for

53 to injury-induced activation of pluripotent somatic stem cells called neoblasts.

54 ferating cells of M. lignano, represented by somatic stem cells, called neoblasts, and germline cells

55 th age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy ag

56 Somatic stem cells contribute to tissue ontogenesis, hom

57 Somatic stem cells cycle slowly or remain quiescent unti

58 maintains both germline stem cells (GSC) and somatic stem cells (CySC).

59 The function of somatic stem cells declines with age.

60 onsible for corto suppression of the GSC and somatic stem cell defects of Yb mutants.

61 p between gene expression and 5hmC in adult (somatic) stem cell differentiation is still unknown.

62 aging mechanisms that erode the function of somatic stem cells during aging, we have conducted a com

63 tosis congenita, a syndrome characterized by somatic stem cell dysfunction in multiple organs leading

64 uently, follicle cell progenitors, including somatic stem cells enter the niche, respond to Dpp, and

65 This work establishes function in somatic stem cells for another member of a putative impr

66 s of cellular physiology remain unstudied in somatic stem cells, for example, there are almost no dat

67 teome throughout life is critical for proper somatic stem cell function, but the complexities of the

68 Because the regenerative potential of somatic stem cells generally weakens with increasing age

69 'Adult' or 'somatic' stem cells harbor an intrinsic ability to regen

70 Somatic stem cells have been claimed to possess an unexp

71 Whether and how age-related changes in somatic stem cells impact the faithful execution of line

72 ands" (CIs) as a niche for putative germ and somatic stem cells in Botryllus schlosseri, a colonial c

73 Resident pools of somatic stem cells in many organs are responsible for ti

74 nsidered one of the most valuable sources of somatic stem cells in regenerative medicine.

75 Here, we demonstrate that somatic stem cells in Schistosoma mansoni are biased tow

76 Understanding the biology of somatic stem cells in self renewing tissues represents a

77 s have recently been considered as potential somatic stem cells in the adult mammalian brain, but the

78 lates the proliferation of both germline and somatic stem cells in the Drosophila melanogaster ovary

79 rdinating the proliferation of germ line and somatic stem cells in the Drosophila ovary.

80 Here we show that somatic stem cells in the Drosophila testis contribute t

81 Adult somatic stem cells in various organs maintain homeostati

82 display slow cycling property, akin to other somatic stem cells, indicating their potential for tissu

83 hanisms that regulate the differentiation of somatic stem cells into specific cell types.

84 get chinmo prevents transformation of testis somatic stem cells into their ovarian counterparts.

85 rates an example in which the maintenance of somatic stem cells is directly influenced by the overall

86 ation; however, the role of these enzymes in somatic stem cells is largely unknown.

87 tent stem cell self-renewal, but its role in somatic stem cells is unknown.

88 cells, but contrary to its critical roles in somatic stem cells, it is dispensable for their prolifer

89 In the Drosophila testis, adult somatic stem cells known as cyst stem cells (CySCs) requ

90 nuanced, ongoing Darwinian evolution at the somatic stem cell level, with EPO identified as a novel

91 The somatic stem cells likely correspond to the ultrastructu

92 Conversely, the feminization of the testis somatic stem cell lineage caused by loss of chinmo is en

93 Somatic stem cells maintain tissue homeostasis by dynami

94 elial cadherin (DE-cadherin) is required for somatic stem cell maintenance and, consequently, the api

95 establish a strict link between dyskerin and somatic stem cell maintenance in a telomerase-lacking or

96 gate the specific role played by dyskerin in somatic stem cell maintenance.

97 Because somatic stem cells may respond to shifts in organismal p

98 hat Wolbachia reach the germline through the somatic stem cell niche in the D. melanogaster germarium

99 st that Wolbachia are highly abundant in the somatic stem cell niche of long-term infected hosts, imp

100 aging DG and provide a blueprint to analyze somatic stem cell niches across lifespan in complex tiss

101 We sought to determine if somatic stem-cell niches more broadly are immune-privile

102 ern reflects maximum telomere restoration in somatic stem cells of early buds and suppression of telo

103 build stochastic mathematical models for the somatic stem cell population to investigate how licensin

104 anism because of the presence of an abundant somatic stem cell population, the neoblasts.

105 the stem cell niche, which itself includes a somatic stem cell population.

106 the selective vulnerabilities that arise in somatic stem cell populations as a result of physiologic

107 Somatic stem cell populations participate in the develop

108 ifically eliminated oogenic stem cells while somatic stem cell populations were not affected.

109 re, in fact, derived from the nuclei of rare somatic stem cells present in adult tissues, rather than

110 esses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neig

111 Ovarian somatic stem cells produce follicle cells, which undergo

112 A dynamic pool of undifferentiated somatic stem cells proliferate and differentiate to repl

113 Precise control of somatic stem cell proliferation is crucial to ensure mai

114 anscription factor, nkx-2.2, is required for somatic stem cell proliferation, suggesting a niche-like

115 a new and tractable control point for adult, somatic stem cell regulation.

116 Long-term maintenance of somatic stem cells relies on precise regulation of self-

117 studies proposing such "plasticity" of adult somatic stem cells remain controversial, and in general,

118 Somatic stem cells require telomerase activity, as evide

119 Somatic stem cells (SCs) uniquely maintain their proteos

120 ISWI and DOM control germline stem cell and somatic stem cell self-renewal in the Drosophila ovary,

121 somatic niche cells to control germ line and somatic stem cell self-renewal.

122 an embryonic stem cells and cells from other somatic stem cell sources.

123 promoting self-renewal and proliferation of somatic stem cells (SSCs) in the Drosophila ovary.

124 t pluripotency in germ stem cells (GSCs) and somatic stem cells (SSCs) may have had shared common evo

125 ated cell adhesion is required for anchoring somatic stem cells (SSCs) to their niches in the Drosoph

126 ision of both germline stem cells (GSCs) and somatic stem cells (SSCs), the two constituent stem cell

127 hog is the only known signal for maintaining somatic stem cells (SSCs).

128 ce of stem cells (germline stem cells, GSCs; somatic stem cells, SSCs) in the Drosophila ovary by spe

129 First, excess Hh signaling in somatic stem cells stimulates somatic cell over-prolifer

130 at the tip of the testis where germline and somatic stem cells surround the apical hub, a cluster of

131 outcomes that the lack of PRC2 can have in a somatic stem cell system.

132 As in other somatic stem cell systems, NSCs are proposed to be predo

133 hms in division frequencies of germ-line and somatic stem cells that act cooperatively to produce mal

134 mammalian model to control the expansion of somatic stem cells that can in principle be applied to a

135 growth and regeneration are fueled by adult somatic stem cells that have yet to be characterized mol

136 In Drosophila, there must also be somatic stem cells that produce the cyst cells that acco

137 rectifying their gene expression, elevating somatic stem cell therapeutic potential beyond solely ce

138 ation, and to assess the plasticity of adult somatic stem cells to become male germ cells.

139 during recurrent epigenetic reprogramming of somatic stem cells to produce, recurrently and reversibl

140 The ability of somatic stem cells to self-renew and differentiate into

141 In Drosophila testes, somatic stem cells transition to a state that licenses t

142 (HSCs) represent one of the first recognized somatic stem cell types.

143 precedented partnership between two distinct somatic stem-cell types and are indicative of a unique n

144 Inactivation of Rb in somatic stem cells typically leads to their overexpansio

145 which human cord blood derived unrestricted somatic stem cells (USSCs) exert therapeutic benefit.

146 stem cell competition, in which germline or somatic stem cells vie for residency in the niche.

147 ifferentiation has become a common claim for somatic stem cells, yet how such cells can be directed t