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1 d-type mice during early embryogenesis (4-36 somites).
2 nd Gli2 to transactivate Myf5 in the epaxial somite.
3 required for Myf5 expression in the epaxial somite.
4 l crest cell migration to the center of each somite.
5 tissues initiate differentiation within the somite.
6 presumptive limb myoblasts emigrate from the somite.
7 on in the anterior compartment of the future somite.
8 to mutually repress each other in the mouse somite.
9 thus full epithelialization of the posterior somite.
10 ut differentiate prematurely adjacent to the somite.
11 g the pharyngeal arches, heart, and anterior somites.
12 c mesoderm, whereas Fgf18 is required in the somites.
13 egments into bilateral tissue blocks, called somites.
14 neck arise from Pax3-expressing cells in the somites.
15 sternal precursors do not originate from the somites.
16 rated embryonic mesodermal structures called somites.
17 a mechanism to specify posterior identity of somites.
18 expression of medium/long Vegfa isoforms in somites.
19 streams, or stall shortly after entering the somites.
20 m migrates in a channel between the skin and somites.
21 derivatives, this enhancer is not active in somites.
22 are held back in order to give rise to later somites.
23 er, these mutants are able to form organized somites.
24 embryo's posterior body, including the tail somites.
25 repulsion at the cell surface in chick half-somites.
26 ors results in complete absence of posterior somites.
27 s associated with an increased cell death in somites.
28 n ceased after the production of about 15-20 somites.
29 nd distal at 4 somites, and distal only at 6 somites.
30 tures" (TLSs) comprising the neural tube and somites.
31 the protein level of phosphorylated p38a in somites.
32 are only able to form roughly half of their somites.
33 vessels, which remodels into the PAAs by 35 somites.
34 ationship of these two regulators in amniote somites.
35 its the expression of cardiac markers in the somites.
36 the muscles for both systems arise from the somites.
37 romotes myotomal extension directly from the somites.
38 al vertebrae, and reduced number of ribs and somites.
39 ardiac progenitors and cardiomyocytes in the somites.
40 ules but to allow expression in the adjacent somites.
41 ogenitors expressing Pax3 are missing in the somites.
42 r, and subsequently in the mid/hindbrain and somites.
43 lves of each vertebra deriving from adjacent somites.
44 gmental de-adhesion and individualization of somites.
45 f the vertebrate embryo's body segments, the somites.
46 o expressed in mesodermal tissues, including somites.
47 mutants exhibited more severe phenotypes in somites.
48 ntial progenitors that normally give rise to somites.
49 er, paraxial mesoderm fails to organize into somites.
50 oevolutionary diversity in limbs, digits and somites.
51 cells oscillate until they incorporate into somites.
54 This allele causes dominant skeletal and somite abnormalities that are distinct from those seen i
56 ate and in vasculogenic regions of the avian somite and are able to promote a vascular endothelial fa
59 rsors migrate across the ventral face of the somite and that junctional adhesion molecules (JAMs) med
60 n (Mb) and Cb by Wnt1 occurs between the one-somite and the six- to eight-somite stages and is solely
61 tures are homologous across vertebrates, how somite and vertebral patterning are connected, and the d
62 y putative regulators of early T-independent somites and challenge the T-Sox2 cross-antagonism model
64 se genes are required for movement away from somites and later to partition two muscles within the fi
65 from the hypaxial dermomyotome of limb level somites and migrate into the limb bud where they form th
67 nt with the shared origin of spinal cord and somites and the distinct ontogeny of the anterior and po
68 6, which drives the VEGFA expression in both somites and the DLP, sit at the top of the adult haemang
69 rafish mutants; (b) the delayed formation of somites and the formation of 'salt and pepper' patterns
70 in the spinal cord, hypothalamus, pituitary, somites and upper jaw, but that Boc might negatively reg
71 tebrates, we tested the relationship between somites and vertebrae in a cartilaginous fish, the skate
73 ormation, was upregulated in mutant cervical somites, and conditional ablation of ectodermal Tbx3 exp
76 lial growth factor A (VEGFA) ligand from the somites, and finally for gata2 expression in the DA, but
77 dorsal medial dermomyotome of newly forming somites, and immunohistological studies show that Zic2 p
78 egmentation of the vertebrate body axis into somites, and later vertebrae, relies on a genetic oscill
79 uently converted into the spatial pattern of somites, and Mesp2 plays crucial roles in this conversio
81 ver, somite size is reduced and later-formed somites are caudalized, coincident with increased cell d
85 termination wavefront, controlling where new somites are permitted to form along the anteroposterior
86 lished early in embryogenesis, when pairs of somites are rhythmically produced by the presomitic meso
90 velopment when the vertebral precursors, the somites, are rhythmically produced from presomitic mesod
94 stream, and that they consequently enter the somites as multiple streams, or stall shortly after ente
95 by expression of Lbx1, are specified in the somite at forelimb level, but endothelial progenitors ar
97 sp quadruple mutant embryos the positions of somite boundaries were clearly determined and morphologi
101 rospectively tracking oscillations of future somite boundary cells, we find that clock reporter signa
102 and that, in zebrafish, the genes regulating somite boundary formation also regulate the development
103 that a gene network previously implicated in somite boundary formation, involving the transcriptional
107 a statistical enrichment of Dvl in notochord-somite boundary-(NSB)-directed protrusions, which is dep
112 nd spatially restricted to the center of the somite, but that motor axons are dispensable for segment
113 ead and some neck muscles do not derive from somites, but mainly form from mesoderm in the pharyngeal
114 for proper patterning of the neural tube and somites by regulating notochord formation, and provide e
115 zebrafish STARS (zSTARS) first occurs in the somites by the 16 somite stage [17 hours post fertilizat
117 gether, our data demonstrate Pax3-expressing somite cells as a source of OSM and SHM fibres, and high
119 of the presomitic mesoderm anterior border, somite chevron morphology and hypaxial myoblast migratio
123 which results in ectopic Fgf8 expression and somite defects, was recruited near the RARb RARE by RA,
127 ineage origin) with their limb and diaphragm somite-derived counterparts, but are remarkably endowed
128 We conclude that the small proportion of somite-derived endothelial cells in the limb is required
129 o initiate myogenesis in branchial arch- and somite-derived muscles are known, but the comparable ups
130 common hallmarks with the prototypic SCs in somite-derived muscles, they distinctively feature robus
131 ta signaling in the development of occipital somite-derived myogenic progenitors during tongue morpho
134 muscles constitute a transition zone between somite-derived skeletal muscles of the trunk and limbs,
135 se elimination is occurring in most EOMs and somite-derived skeletal muscles, it appears to be dramat
137 /-) chimeric embryos shows that the anterior somites develop in the absence of T and suggests a cell-
138 Blastopore closure, notochord formation, somite development, neural tube closure, and the formati
145 and Zic1 in transactivating the Myf5 epaxial somite (ES) enhancer in concert with the Myf5 promoter.
147 genitors can be transfated from notochord to somite fate after gastrulation by ectopic expression of
152 h a role for ntl in mesoderm formation, some somites form within the tail region of embryos lacking n
153 ck' activity that governs the periodicity of somite formation and (iii) preserve the composition and
154 wavefront determines the spatial position of somite formation and the somitogenesis clock controls pe
155 segmentation was significantly affected, and somite formation ceased after the production of about 15
159 ranial neural crest cell-streams relative to somite formation is accelerated in rapidly developing fr
163 ranscription factors Ntla and Tbx16 regulate somite formation upstream of this by controlling supply
164 ggest that the segmentation clock may signal somite formation using a phase gradient with a two-somit
167 cs of cells in the tailbud and their role in somite formation, we have analyzed the genetic factors a
168 of miRNAs in mesoderm development including somite formation, we used T (Brachyury)-Cre mouse line t
177 ized by the periodic formation of epithelial somites from the mesenchymal presomitic mesoderm (PSM).
178 ing genes, controls the periodic cleavage of somites from unsegmented presomitic mesoderm during vert
182 ipotent Pax3-positive (Pax3(+)) cells in the somites give rise to skeletal muscle and to cells of the
189 mental features of the vertebrate body - the somites - in which beta1-integrin activity regulates epi
191 formation of an ectopic tail, which contains somites, in embryos devoid of nodal signalling, and this
194 le progenitor cells migrate from the lateral somites into the developing vertebrate limb, where they
195 whereby migration of myogenic cells from the somites into the limb bud is followed by their extension
197 l plate mesoderm (LPM) adjacent to occipital somites is a recently identified embryonic source of cer
198 nt embryos, Myf5 expression in newly forming somites is deficient in both sonic hedgehog(-/-) and in
202 n patterns during development of the palate, somite, kidney, and testis, suggesting that it may be an
204 e the ribs have been shown to arise from the somites, little is known about how the two segments are
205 esoderm markers such as Tcf15 and Meox1, and somite markers such as Uncx, but failed to express scler
206 a in zebrafish embryos: (a) the variation in somite measurements across a number of zebrafish mutants
216 show that RARbeta2 plays a specific role in somite number and size, restriction of the presomitic me
218 xial and abaxial domains and by increases in somite number, not by changes in the function of primaxi
225 nopus skeletal muscle development, including somite organization, migration of hypaxial muscle anlage
226 ecify posterior otic identity between the 10 somite (otic placode) and 20 somite (early otic vesicle)
227 se gastrula between Early Streak (ES) and 12-somite pair (-s) stages (~6.75-9.0 days post coitum, dpc
228 ing phenotypes in the segmentation clock and somite patterning of mutant mice suggest that LFNG prote
229 Less is understood about how RAR regulates somite patterning, rostral-caudal boundary setting, spec
232 regions, which direct Eya1 expression to the somites, pharyngeal pouches, the preplacodal ectoderm (t
233 to ligand and its localization in the trunk somites positions it at the right time and place to resp
234 defects in somite segmentation and a loss in somite posterior polarity leading to fusions of vertebra
237 naling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into
241 Fgf and Hedgehog function between 10 and 20 somites results in symmetrical otic vesicles with neithe
242 REB family in the mesoderm causes defects in somite segmentation and a loss in somite posterior polar
243 ignaling as a means to orchestrate cells for somite segmentation and anterior/posterior patterning.
244 unction of PAPC in chicken embryos disrupted somite segmentation by altering the CDH2-dependent epith
246 e functions of the two Delta proteins in the somite segmentation clock--an explanation that is based
248 on changes in mesoderm development uncovered somite segmentation, a previously unobservable human emb
249 nic mesoderm, while Dicer is dispensable for somite segmentation, it is essential for proper limb bud
250 Knockdown of itgalpha6b resulted in abnormal somite shape, fewer somitic cells, weaker or absent myf5
251 Accordingly, LPM adjacent to the occipital somites should be regarded as posterior cranial mesoderm
254 sion, and leads to a persistent reduction in somite size until at least the independent feeding stage
255 ransactivation of Gli-dependent Myf5 epaxial somite-specific (ES) enhancer activity in 3T3 cells, and
259 is gene, dissections were performed on early somite stage embryos during an eight-hour time window of
260 e endocardial progenitors as early as the 10-somite stage which suggests that Hh signaling is require
261 ls, labeled by lipophilic dye at the 4- to 6-somite stage, to regions of the heart at 20 to 25 somite
262 data, and in situ hybridization analysis of somite-stage embryos, we carried out comparative analyse
263 between the one-somite and the six- to eight-somite stages and is solely dependent on Wnt1 function i
264 In our model, specification occurs during somite stages due to varying Hedgehog protein levels, wh
265 ing such that during late gastrula and early somite stages of embryogenesis, Wnt activity must be sup
266 ryos show that Cubn is required during early somite stages to convey survival signals in the developi
268 left wall of the KV between the six- and 12-somite stages, which is coincident with known left-sided
269 ent and, in particular, in the regulation of somite survival and axial rotation, a crucial developmen
270 id signalling, which is required to maintain somite symmetry by interacting with Fgf8 in the left-rig
273 ween different tissues derived from the same somites that contribute to the structures of the cervica
274 mesoderm treated with Noggin generates many somites that form simultaneously, without cyclic express
275 estricted to the hypaxial region of anterior somites that generate migratory muscle precursors (MMPs)
276 er dorsal and lateral to neural tube and the somites that is normally formed by PNA-binding proteins
277 al skeletal elements arise from the paraxial somites, the appendicular skeleton and sternum arise fro
278 S that was introduced into a subset of chick somites, the progenitors that give rise to dermis and mu
280 motifs of vertebrate bodies and organs, the somites, the skeletons of the paired limbs, and musculos
281 k neural crest along the rostral side of the somites, the ventromedial pathway, the branchial arches,
282 ebrafish development, derive from the caudal somites through an epithelial-mesenchymal transition (EM
283 is non-cell-autonomous, and acts within the somite to bridge the Wnt and Notch signalling pathways.
284 or is required earlier within the developing somite to regulate HSC emergence in a non-cell-autonomou
285 that Notch3 performs a novel role within the somite to regulate the neighboring precursors of hemogen
286 sduction of requisite Notch signals from the somite to the precursors of HSCs, and that these events
288 recursor cells (MPCs) have migrated from the somites to the limb bud and populated the prospective mu
289 hypaxial muscle precursors from the anterior somites undergo long-range migration, moving away from t
291 is expressed prominently in the brain, eyes, somites, ventral blood island and branchial arches.
293 f11r) and migrate axially across the ventral somite, where Jam2a and the Notch ligands Dlc and Dld ar
294 nic development, skeletal muscles arise from somites, which derive from the presomitic mesoderm (PSM)
295 engrailed-1 (en1) staining in anterior trunk somites, which is dependent on Hedgehog (Hh) signaling.
296 l distribution corresponding to the injected somites, which suggests that blocking GNAS activity in a
297 Zebrafish ortholog of Nogo-B is expressed in somite while expression of zebrafish NgBR is localized i
298 anterior gradient of stable Cdh2 within each somite, while there is a step-like drop in stable Cdh2 a
299 in Matrigel induces gastruloids to generate somites with the correct rostral-caudal patterning, whic
300 the paraxial mesoderm becomes segmented into somites, within which proliferative muscle progenitors a