ライフサイエンスコーパス: somitogenesis

1 s they wait for the signal to begin entering somitogenesis.

2 nd essential role for RARbeta2 in vertebrate somitogenesis.

3 during the course of gastrulation and early somitogenesis.

4 cad-3 and thereby to disruption of posterior somitogenesis.

5 grin-dependent migration and adhesion during somitogenesis.

6 control of early/anterior and late/posterior somitogenesis.

7 respond to embryonic retinoid levels during somitogenesis.

8 les rapidly, over a 4-hour window during mid-somitogenesis.

9 erm) results in random left-right asymmetric somitogenesis.

10 , and thus in ensuring bilaterally symmetric somitogenesis.

11 ells delaminate in blf morphants during late somitogenesis.

12 y have a gamma-secretase-independent role in somitogenesis.

13 with a critical role for N signaling during somitogenesis.

14 ilin in particular was analyzed during mouse somitogenesis.

15 Notch pathway mutants show severe defects in somitogenesis.

16 roles of this pathway in different steps of somitogenesis.

17 mitic mesoderm, tail bud, and somites during somitogenesis.

18 esomitic mesoderm and is required for normal somitogenesis.

19 ific tissues during posterior elongation and somitogenesis.

20 rbed motor axon outgrowth, neurogenesis, and somitogenesis.

21 tion, and unilateral expression during early somitogenesis.

22 that are thought to control segmentation and somitogenesis.

23 , beta-catenin and Lef1 are expressed during somitogenesis.

24 hogenetically plastic during early embryonic somitogenesis.

25 tion and in the prechordal plate until early somitogenesis.

26 e signal transduction pathways that regulate somitogenesis.

27 formation of a segmental prepattern prior to somitogenesis.

28 lineage and could play a role in regulating somitogenesis.

29 establishes a segmental prepattern prior to somitogenesis.

30 he period of tail bud development for caudal somitogenesis.

31 indbrain boundary region at the beginning of somitogenesis.

32 emical-biomechanical interactions that drive somitogenesis.

33 echanism, similar to that driving vertebrate somitogenesis.

34 rganoids, recapitulating critical aspects of somitogenesis.

35 cture of the axial skeleton is formed during somitogenesis.

36 es to elucidate the mechanisms that underlie somitogenesis.

37 d Shh, which may be functionally involved in somitogenesis.

38 me points spanning zebrafish gastrulation to somitogenesis.

39 mechanism maintaining cell synchrony during somitogenesis.

40 e anterior neural tube, axial elongation and somitogenesis.

41 xis formation, neuroectoderm patterning, and somitogenesis.

42 on of miR-19 family members during zebrafish somitogenesis.

43 sential for proper segmentation during chick somitogenesis.

44 rs (NMPs) are set aside for subsequent trunk somitogenesis.

45 tail elongation, mesodermal development and somitogenesis.

46 t1, NOTCH signaling is subtly reduced during somitogenesis.

47 axis elongation, cell fate specification and somitogenesis.

48 orter in the tailbud, PSM and somites during somitogenesis.

49 entation is initiated through the process of somitogenesis.

50 ed towards certain fates at the beginning of somitogenesis.

51 s that are essential for both myogenesis and somitogenesis.

52 ny one gene is insufficient to disrupt early somitogenesis.

53 ature of vertebrates and is patterned during somitogenesis.

54 nalogous to that operating during vertebrate somitogenesis.

55 xhibits a variable expression pattern during somitogenesis.

56 gene from early (8.5 dpc) to late (10.5 dpc) somitogenesis.

57 in Bmp4 activity that lasts throughout early somitogenesis.

58 ant to examine the role of the cell cycle in somitogenesis.

59 distinct ways in both midline formation and somitogenesis.

60 into skeleton, fast, and slow muscles during somitogenesis.

61 ression which is necessary for regulation of somitogenesis.

62 atterning during late gastrulation and early somitogenesis.

63 To dissect the roles played by Lfng during somitogenesis, a novel allele was established that lacks

64 dy plan of vertebrates is established during somitogenesis, a well-studied process in model organisms

65 gulatory factors (MRFs) are expressed during somitogenesis although cells with myogenic capacity are

66 tigated their potential requirement in mouse somitogenesis, an event with precise temporal periodicit

67 fish impaired motor neuron specification and somitogenesis and abolished neuromuscular junction forma

68 platform for decoding general principles of somitogenesis and advancing knowledge of human developme

69 reiterating pattern that is coordinated with somitogenesis and also colocalizes with the Notch ligand

70 bit severe defects in neural tube formation, somitogenesis and cardiac development, have aberrant vas

71 mental periodicity represented by vertebrate somitogenesis and early Drosophila development.

72 se staining, was first detected during early somitogenesis and gradually expanded to other tissues of

73 developing trunk similar to how RA controls somitogenesis and heart development.

74 ls indicate that developmental plasticity in somitogenesis and HOX gene expression in the axial skele

75 s uncover an unexpected relationship between somitogenesis and left-right patterning, and suggest tha

76 Classical models of somitogenesis and limb development implicated intrinsic

77 major sites of expression implicate Dll3 in somitogenesis and neurogenesis and in the production of

78 n Notch-Delta signaling result in defects in somitogenesis and neurogenesis.

79 e unsegmented mesenchymal PSM while blocking somitogenesis and notochord differentiation.

80 e ontogenesis of the posterior embryo during somitogenesis and of kidney, mesenchyme, retina and earl

81 est that GCNF is required for maintenance of somitogenesis and posterior development and is essential

82 t mouse mutation that disrupts pigmentation, somitogenesis and retinal cell fate determination.

83 ignalling in the segmental plate to regulate somitogenesis and rostral-caudal patterning of somites s

84 We apply a CO model to vertebrate somitogenesis and show that we can reproduce the dynamic

85 development, with both apparent during early somitogenesis and subsequently down-regulated as develop

86 t led us to investigate the relation between somitogenesis and the left-right asymmetry machinery in

87 nscription factors, plays a critical role in somitogenesis and the pathogenesis of lumbar/sacral vert

88 broad and balanced cross-species overview of somitogenesis and to highlight the key molecular and cel

89 restricted to the posterior mesoderm during somitogenesis and to posterior mesoderm organs at pharyn

90 haly with small eye formation, disruption of somitogenesis, and curved body axis with bent tail.

91 rive Fgfr1 functions during gastrulation and somitogenesis, and drives normal MAPK responses to Fgf.

92 enesis during gastrulation, brain formation, somitogenesis, and heart development.

93 Fgfr1, leading to earlier lethality, reduced somitogenesis, and more severe changes in transcriptiona

94 ogenetic events, including axial elongation, somitogenesis, and neural tube formation.

95 y within the neuroectodermal lineages during somitogenesis, and second, they show an altered brain mo

96 play distinct roles in axial elongation and somitogenesis, and that FGF signaling gradients drive se

97 While somitogenesis appears to be a serially homologous, reite

98 gastruloids, and show that key regulators of somitogenesis are expressed similarly between embryos an

99 tion and suggest that the earliest stages of somitogenesis are regulated by both Notch-dependent and

100 e targets of retinoic-acid signalling during somitogenesis are the node ectoderm and the posterior ne

101 e vertebrate body plan is established during somitogenesis as somite pairs sequentially form along th

102 duced within the myotome are correlated with somitogenesis as well as myocyte maturation.

103 ant from the 1-cell stage until the onset of somitogenesis, at which time it increased sharply.

104 e, Gax protein was expressed at the onset of somitogenesis before the expression of the myogenic basi

105 vel of RA generation was detected as soon as somitogenesis began.

106 During later somitogenesis, blf expression appears only in hematopoie

107 on, while during late gastrulation and early somitogenesis, blf expression becomes transiently restri

108 are all are known to be essential for normal somitogenesis but are expressed surprisingly early in th

109 , deltaC(tv2) cannot function effectively in somitogenesis but has an enhanced ability to signal duri

110 Thus, Wnt3a regulates somitogenesis by activating a network of interacting tar

111 ling specifically in lateral mesoderm during somitogenesis, by targeting a dominant-negative BMP rece

112 d severe defects in neural tube development, somitogenesis, cardiogenesis and vascular remodeling.

113 Throughout somitogenesis, Cdh2 promotes ECM assembly along tissue b

114 During somitogenesis, cells are recruited to the caudal presomi

115 spatial position of somite formation and the somitogenesis clock controls periodicity.

116 e is essential for normal functioning of the somitogenesis clock in zebrafish.

117 Using live imaging, we show that the somitogenesis clock is active in gastruloids and has dyn

118 Previous mathematical models of the somitogenesis clock that invoke the mechanism of delayed

119 equirement for RPTPpsi in the control of the somitogenesis clock upstream of or in parallel with Delt

120 pluripotency is extinguished at the onset of somitogenesis, coincident with reduced expression and ch

121 Notochord segmentation begins days after somitogenesis concludes and can occur in its absence.

122 eloping spine, and increasing sensitivity to somitogenesis defects associated with congenital scolios

123 Somitogenesis displays great autonomy, and it is general

124 We postulate that during somitogenesis Dll3 and Dll1 coordinate in establishing t

125 Somitogenesis during early stages in the chick and mouse

126 e segmentation of the body is established by somitogenesis, during which somites form sequentially in

127 ate mapping of mesodermal derivatives in mid-somitogenesis embryos suggests that EMPs are born direct

128 During somitogenesis, epithelial somites form from the pre-somi

129 Somitogenesis establishes the segmental pattern of the v

130 Prior to somitogenesis expression of both Nanog and Oct4 is regio

131 During somitogenesis, Fak protein becomes concentrated at the b

132 ciliated KV cells are required during early somitogenesis for subsequent LR patterning in the brain,

133 thway plays multiple roles during vertebrate somitogenesis, functioning in the segmentation clock and

134 that the segmentation clock, which regulates somitogenesis, functions normally in the absence of cell

135 w, we summarize the current understanding of somitogenesis gained from both in vivo studies and in vi

136 ents including primitive streak development, somitogenesis, gut tube formation, neural tube patternin

137 lysis of differential gene expression during somitogenesis has been problematic due to the limited am

138 ession, related to the segmentation process (somitogenesis), has been identified in chick, mouse, and

139 is, are recessive monogenic traits affecting somitogenesis, however the etiologies of the majority of

140 r normal somite formation and that defective somitogenesis in b567 mutant embryos is due to deletion

141 -5), models that robustly recapitulate human somitogenesis in both space and time remain scarce.

142 onsistent with available data on the rate of somitogenesis in humans.

143 onent of the Notch signalling pathway during somitogenesis in mice.

144 nd of the presomitic mesoderm prior to overt somitogenesis in response to both Mesp2 and Notch signal

145 tameric organization is first implemented by somitogenesis in the early embryo, when paired epithelia

146 Ret1 mRNA first appears during early somitogenesis in the presumptive brain, spinal cord and

147 that the VER produces signals necessary for somitogenesis in the tail and that the cells that produc

148 This is particularly true for somitogenesis in the zebrafish.

149 s in the failure of convergent extension and somitogenesis in this tissue.

150 ons in neurogenic ectoderm of Drosophila and somitogenesis in vertebrate presomitic mesoderm.

151 a model system for exploring development and somitogenesis in vitro in a high-throughput manner.

152 Somitogenesis in vivo involves intricately orchestrated

153 during embryogenesis through the process of somitogenesis in which the paraxial mesoderm periodicall

154 py to analyze the mechanics underlying early somitogenesis in wild-type zebrafish and in the mutants

155 f actin regulatory proteins are required for somitogenesis in Xenopus.

156 ities in the genetic mechanisms underpinning somitogenesis in zebrafish and segmentation in the spide

157 We find that Bmp signaling continues during somitogenesis in zebrafish embryos, with high activity i

158 controlling somite number, we have compared somitogenesis in zebrafish, chicken, mouse and corn snak

159 and Zeeman's 'clock and wavefront' model of somitogenesis, in which a travelling wavefront determine

160 and-wavefront' mechanism operates to control somitogenesis; in all of them, somitogenesis is brought

161 ause multiple morphogenetic abnormalities in somitogenesis, including defects in intersomitic boundar

162 ajor patterning modules that are involved in somitogenesis, including the clock and wavefront, antero

163 hown to regulate morphogenetic events during somitogenesis, including the transition of cells from me

164 lation and neurulation, both neurulation and somitogenesis initiate apparently normally in homozygous

165 e deconstruct the spatiotemporal dynamics of somitogenesis into four distinct modules: dynamic events

166 Somitogenesis involves the segmentation of the paraxial

167 Somitogenesis is a highly controlled process that result

168 es to control somitogenesis; in all of them, somitogenesis is brought to an end through a process in

169 Somitogenesis is controlled in part by a segmentation cl

170 ng from the mid-gastrula stage through early somitogenesis is important for excluding blood and vascu

171 ells into the presomitic mesoderm throughout somitogenesis is not understood.

172 Somitogenesis is regulated by a molecular oscillator tha

173 Vertebrate somitogenesis is regulated by a segmentation clock.

174 d spatial control underlying this process of somitogenesis is regulated by the segmentation clock and

175 In Foxc1/2 double-mutant embryos, somitogenesis is severely affected, precluding analysis

176 retation of the clock and wavefront model of somitogenesis is that a posteriorly moving molecular gra

177 Somitogenesis is the process by which the segmented prec

178 Somitogenesis is thought to be controlled by a segmentat

179 quired suppression of wnt signaling in early somitogenesis; later, increased wnt activity altered end

180 ryos lacking RA results in a reversal of the somitogenesis laterality defect.

181 Herein, we develop a human somitogenesis model by confining hPSC-derived presomitic

182 The microfluidic somitogenesis model is further exploited to reveal regul

183 However, none of the current somitogenesis models controls biochemical gradients or b

184 Particularly, there are hPSC-based somitogenesis models using free-floating culture that re

185 During somitogenesis, ndr2 is expressed asymmetrically in the l

186 ene expression oscillations occurring during somitogenesis, neurogenesis, myogenesis and pancreas dev

187 s identifying the role of Dll3 in regulating somitogenesis, Nrarp emerges as a potentially important

188 2, but not lft1, expression is absent during somitogenesis of most cavefish.

189 d protein that plays specific roles in early somitogenesis of vertebrates.

190 er in gastrulation has no apparent effect on somitogenesis or elongation of the embryo.

191 er defects in hypochord formation but not in somitogenesis or hindbrain neurogenesis, indicating gene

192 n syndrome may arise through perturbation of somitogenesis or, alternatively, could result from defec

193 eriod, resembling that of the mouse or chick somitogenesis oscillator and governed by the delays in t

194 During somitogenesis, oscillatory expression of genes in the no

195 ts, indicating that the presomitogenesis and somitogenesis phases of MyoD expression can be uncoupled

196 Somitogenesis plays a key role in embryo morphogenesis a

197 he ventral cells throughout gastrulation and somitogenesis, previous studies in zebrafish have not ad

198 Prior to somitogenesis, RALDH-2-IR is present in the paraxial mes

199 is generally assumed in the literature that somitogenesis-related oscillations are cell-autonomous i

200 gations, but the role of Notch signalling in somitogenesis remains mysterious.

201 Somitogenesis requires a segmentation clock and Notch si

202 Somitogenesis requires bilateral rhythmic segmentation o

203 of activated Notch (NICD) and establish that somitogenesis requires less NICD than any other tissue i

204 e formation of VM, independent of defects of somitogenesis, resulting from aberrant bone deposition a

205 patterning defects at the earliest stages of somitogenesis, resulting in adult mice with severe verte

206 Ectopic activation of Bmp signaling during somitogenesis results in severe defects in the tailbud,

207 During vertebrate somitogenesis, retinoic acid is known to establish the p

208 During somitogenesis, segmental patterns of gene activity provi

209 We argue that this is because somitogenesis shows uncoupling or dissociation from the

210 Overexpression of Bmp during somitogenesis similarly results in bilateral livers and

211 uctors of left-right (LR) asymmetry in early somitogenesis stage embryos.

212 y in the caudal region of embryos during the somitogenesis stage.

213 of the two elements is sufficient to confer somitogenesis-stage expression to a tbxta promoter that,

214 Enforced Oct4 expression in somitogenesis-stage tissue provokes rapid reopening of O

215 and p1 domain markers are expressed at early somitogenesis stages in these mutants.

216 plate mesoderm (L LPM) during tailbud/early somitogenesis stages is associated in all vertebrates ex

217 from the completion of gastrulation to early somitogenesis stages to regulate BMP signaling.

218 es from a normalized cDNA library from early somitogenesis stages were picked randomly and tested by

219 following heat-shock, we found that at late somitogenesis stages Wnt8a, but not Bmp2b, overexpressio

220 However, from mid-gastrulation to the early somitogenesis stages, Bmp signaling is important for ven

221 wn of Etv2 in zebrafish embryos prior to mid-somitogenesis stages, but not later, caused severe vascu

222 During late somitogenesis stages, Gli3 is required as a repressor of

223 During somitogenesis stages, the anterior expression of mbx, wh

224 At early somitogenesis stages, when the zebrafish endoderm first

225 educed in size in mbx-MO-injected embryos by somitogenesis stages.

226 g specifically during gastrulation and early somitogenesis stages.

227 beta-Catenin involvement in somitogenesis suggests a role for Wnt-mediated signaling

228 The prevailing model of somitogenesis supposes that the presomitic mesoderm is s

229 Maintenance of somitogenesis symmetry requires retinoic acid (RA) and i

230 inoic acid (RA) regulates the maintenance of somitogenesis symmetry.

231 This includes a signature of somitogenesis that suggests that 72-h human gastruloids

232 os to show that WIF-1 overexpression affects somitogenesis (the generation of trunk mesoderm segments

233 Furthermore, at the end of somitogenesis, the cell count of radial glia and trigemi

234 tween cell-cell and cell-ECM adhesion during somitogenesis, the formation of the segmented embryonic

235 During somitogenesis, the Nrarp gene is expressed in a pattern

236 Somitogenesis, the sequential formation of a periodic pa

237 During gastrulation and early somitogenesis, the ventral midline of the central nervou

238 rly expressed Bmp inhibitors function during somitogenesis to constrain Bmp signaling in the tailbud

239 late gastrulation and lasting through early somitogenesis to promote chordamesoderm proliferation.

240 tor, drive the formation of somites and link somitogenesis to the elongation of the anteroposterior a

241 hin nascent somites, from early inception of somitogenesis to the latest stages of body plan establis

242 of a mutation detected in T-ALL patients on somitogenesis using human iPSC-derived PSM cells and som

243 1 die at midgestation with severe defects in somitogenesis, vasculogenesis, cardiogenesis, and neurog

244 ing Drosophila wing formation and vertebrate somitogenesis, we suggest that these boundaries constitu

245 The late stages of somitogenesis were rescued in Raldh2(-/-) mouse embryos

246 ell stage and allowed to develop until early somitogenesis when endogenous PLA(2) activity increases

247 xample in vertebrate embryos is found during somitogenesis, where gene expression oscillations linked

248 This is clear during somitogenesis, where progenitors must be allocated to th

249 ontrol the period of somite formation during somitogenesis, whereas they regulate the proliferation-t

250 dividual somites adopt distinct fates during somitogenesis, which is crucial for establishing the met

251 deployed for segmentation during vertebrate somitogenesis, which raises the possibility of a common

252 efects in trunk development, specifically in somitogenesis, which terminates by 8.75 dpc.

253 axis, reduced head structure, and perturbed somitogenesis, which were also found in embryos treated

254 erm-based 3D model of human segmentation and somitogenesis-which we termed 'axioloid'-that captures a

255 mp signaling is continuously required during somitogenesis within the anterior lateral plate mesoderm