ライフサイエンスコーパス: sonic

1 In fishes, sonic abilities for communication purpose usually involv

2 We show that sonic activity allows a clear distinction between a diur

3 Similarities with characters in other sonic and weakly electric teleost fish provide a strikin

4 relaxation boom in analogy to the classical sonic boom.

5 Sonic caterpillars are found in many distantly-related g

6 lysis buffer augmented with a 2s pulse of a sonic cell disruptor.

7 so show that the two nonsynodontids are only sonic, consistent with sound production being an ancestr

8 se powder for subgingival air-polishing with sonic debridement in residual periodontal pockets during

9 der with an air-polishing device (test) or a sonic device (control).

10 we show that some caterpillars also exhibit sonic displays.

11 The vibrational spectrum displays a sonic gap populated by topologically protected edge mode

12 harges on bathymetric highs characterized by sonic hard grounds, whereas glaciomarine and Holocene se

13 was reduced at multiple stages, whereas the Sonic hedgehog (Hh [Shh])-deficient FL showed increased

14 BCC is primarily driven by the Sonic Hedgehog (Hh) pathway.

15 he lysine-II&V/phenylalanine degradation and sonic hedgehog (Hh) pathways in reversible TMZ-effect ce

16 pression of genes encoding components of the Sonic Hedgehog (Hh) signaling pathway, a driver of mamma

17 c patients with the medulloblastoma subgroup Sonic Hedgehog (MB(SHH))(.) ELP1 was the most common med

18 Furthermore, we provide evidence that Sonic hedgehog (Shh) activates Gli2 by stimulating its p

19 Aberrant Sonic hedgehog (Shh) activation during adulthood leads t

20 ane, boosting cell sensitivity to the ligand Sonic Hedgehog (SHH) and consequently altering SHH-guide

21 Here, we investigated how Sonic hedgehog (Shh) and Fibroblast growth factor (Fgf)

22 sor cells, which express the secreted factor sonic hedgehog (Shh) and give rise to taste bud cells th

23 ed subgroup of medulloblastoma, is driven by Sonic hedgehog (Shh) and insulin-like growth factor (IGF

24 causes derepression of several genes, e.g., Sonic hedgehog (Shh) and Insulin-like growth factor-bind

25 The presence of Sonic Hedgehog (Shh) and its signaling components in the

26 (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of th

27 Sonic hedgehog (Shh) and Sca1, markers of aortic osteoge

28 Signaling networks controlled by Sonic hedgehog (SHH) and the transcription factor Atoh1

29 be (central nervous system, CNS), depends on Sonic hedgehog (SHH) as a main signaling morphogen.

30 ich constitute the core reception system for sonic hedgehog (SHH) as well as GLI transcription factor

31 Sonic hedgehog (Shh) attracts spinal cord commissural ax

32 HS production around the lesion allows Sonic hedgehog (Shh) binding and favors the local enrich

33 The secreted Hedgehog ligand Sonic Hedgehog (SHH) binds to its receptor Patched1 (PTC

34 Epithelial-specific deletion of sonic hedgehog (Shh) during postnatal homeostasis in the

35 re able to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 an

36 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic patter

37 We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin, and Hh pathway

38 Sonic hedgehog (Shh) expression in the limb bud organizi

39 In Ftm (-/-) embryos, Sonic hedgehog (Shh) expression was virtually lost in th

40 his region were observed including decreased Sonic hedgehog (Shh) expression, abnormal cell adhesion,

41 anisms, consisting of iterative signaling by Sonic hedgehog (SHH) followed by Bone morphogenetic prot

42 ), and that gustatory nerves are a source of sonic hedgehog (Shh) for taste bud renewal.

43 demonstrate a requirement for the Hh ligand Sonic Hedgehog (Shh) for the progression of SCLC.

44 Loss of expression of Sonic Hedgehog (Shh) from parietal cells results in hype

45 All tumor samples clustered within the sonic hedgehog (SHH) group.

46 ling in axon guidance.SIGNIFICANCE STATEMENT Sonic hedgehog (Shh) guides axons via a noncanonical sig

47 Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been

48 a perineural microenvironment, and deleting Sonic hedgehog (Shh) in neurons or Smoothened in the epi

49 tion and histone modification, is induced by Sonic Hedgehog (SHH) in SHH-dependent cerebellar progeni

50 Six2creFrs2alphaKO interstitium and ectopic sonic hedgehog (Shh) in subsets of non-dilated P7 mutant

51 e in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two s

52 We showed that gigaxonin governs Sonic Hedgehog (Shh) induction, the developmental pathwa

53 Sonic hedgehog (Shh) is a mitogen for spinal cord progen

54 Sonic hedgehog (Shh) is a morphogenic protein that opera

55 Sonic hedgehog (Shh) is a multifunctional signaling prot

56 Sonic hedgehog (Shh) is a secreted protein that controls

57 Sonic Hedgehog (Shh) is abnormally expressed in pancreat

58 Sonic hedgehog (SHH) is an essential morphogenetic signa

59 Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fa

60 The signaling protein Sonic Hedgehog (SHH) is crucial for the development and

61 Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patte

62 In the early limb bud, for instance, Sonic hedgehog (Shh) is expressed in the distal posterio

63 The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal meso

64 Sonic Hedgehog (Shh) is normally present in the axons of

65 pment and cancer: it covalently modifies the Sonic hedgehog (SHH) ligand, restricting its release fro

66 n progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively.

67 Zeb1 expression is elevated in the Sonic Hedgehog (SHH) medulloblastoma subgroup originatin

68 Sonic Hedgehog (SHH) medulloblastomas are brain tumours

69 velopmental hierarchy of progenitor pools in Sonic Hedgehog (SHH) medulloblastomas, and identified OL

70 small nuclear RNAs (snRNAs) in about 50% of Sonic hedgehog (SHH) medulloblastomas.

71 ere treated with Smoothened Agonist (SAG), a Sonic Hedgehog (Shh) mimetic in order to fortify blood b

72 The CXCR4 chemokine and Sonic Hedgehog (SHH) morphogen pathways are well-validat

73 tiation, causing limb defects that phenocopy Sonic Hedgehog (Shh) mutants.

74 Stimulation with Sonic Hedgehog (Shh) of primary mammary mesenchymal cell

75 h ectopic expression of the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with

76 ry cilium to promote Smo phosphorylation and Sonic hedgehog (Shh) pathway activation.

77 Treatment with the Sonic hedgehog (Shh) pathway agonist purmorphamine or cy

78 ntified in genes involving regulation of the sonic hedgehog (Shh) pathway in 14/38 individuals (37%).

79 s result in transcriptomic activation of the Sonic Hedgehog (SHH) pathway in SSTs.

80 Stimulation of the sonic hedgehog (Shh) pathway in vertebrates results in a

81 udies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smooth

82 The Sonic Hedgehog (SHH) pathway is a key signaling pathway

83 We found that a noncanonical Sonic Hedgehog (Shh) pathway is rapidly activated in res

84 SCLC) often features the upregulation of the Sonic hedgehog (Shh) pathway leading to activation of Gl

85 The Sonic Hedgehog (SHH) pathway plays a key role in cancer.

86 (REST) is increased in tumors driven by the sonic hedgehog (SHH) pathway, specifically the SHH-alpha

87 ntiation; and RGS5, decay of which activates Sonic Hedgehog (SHH) pathway-mediated differentiation of

88 y, and IGF-1 expression was regulated by the Sonic Hedgehog (Shh) pathway.

89 is controlled by hormonal regulation of the Sonic hedgehog (Shh) pathway.

90 Using Sonic hedgehog (Shh) patterning of the ventral neural tu

91 Sonic hedgehog (SHH) plays a central role in patterning

92 thelial buds and suppress epithelial-derived sonic hedgehog (SHH) production.

93 Here, we present a system to trigger a Sonic Hedgehog (SHH) protein gradient in developing fore

94 patient carrying a germline mutation in the sonic hedgehog (SHH) receptor PTCH1.

95 egulation of the Ptch1 gene, which encodes a Sonic hedgehog (SHH) receptor, is disrupted specifically

96 oding a transmembrane protein related to the Sonic hedgehog (Shh) receptor, Patched, and involved in

97 c hippocampal neurons in which activation of Sonic Hedgehog (Shh) receptors in dendrites stimulates a

98 Sonic Hedgehog (SHH) reduces ciliary cAMP levels, inhibi

99 We provide evidence here that sonic hedgehog (Shh) secreted from the gut epithelium pr

100 Sonic hedgehog (Shh) signal transduction specifies ventr

101 Sonic hedgehog (Shh) signal transduction was downregulat

102 s and has been hypothesized to contribute to Sonic hedgehog (Shh) signaling and synapse formation.

103 n the present study, we uncovered a role for sonic hedgehog (SHH) signaling during lip fusion.

104 We found that constitutively active Sonic hedgehog (Shh) signaling expanded bRGs and IPCs an

105 for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven

106 Here, we show that Sonic hedgehog (Shh) signaling in mature astrocytes is r

107 helia and underlying stroma due to paracrine Sonic hedgehog (SHH) signaling in producing desmoplasia

108 Normally, sonic hedgehog (Shh) signaling induces high levels of Pa

109 In the healthy, adult CNS, Sonic hedgehog (Shh) signaling is active in mature, diff

110 l) mice were used to establish that impaired Sonic hedgehog (Shh) signaling is associated with loss o

111 Sonic hedgehog (Shh) signaling is critical in developmen

112 Although sonic hedgehog (SHH) signaling is known to activate CGNP

113 In the developing cerebellum, Sonic hedgehog (SHH) signaling is required for expansion

114 t, in hippocampal neurons, activation of the Sonic hedgehog (Shh) signaling pathway affects multiple

115 through changes in genes associated with the sonic hedgehog (SHH) signaling pathway, required for spa

116 oma are driven by aberrant activation of the Sonic Hedgehog (SHH) signaling pathway.

117 Sonic hedgehog (Shh) signaling patterns the vertebrate s

118 We report herein that sonic hedgehog (Shh) signaling plays a key role in catar

119 Mutations in Sonic hedgehog (SHH) signaling promote aberrant prolifer

120 ant rescued mandibular morphogenesis through sonic hedgehog (SHH) signaling to the mesenchyme.

121 Reduced sonic hedgehog (SHH) signaling was confirmed by in situ

122 PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regu

123 when maintained in a proliferative state by sonic hedgehog (Shh) signaling, and Aspm is expressed in

124 granule neuron precursors (CGNPs) induced by Sonic Hedgehog (SHH) signaling, but downstream effectors

125 In Sonic hedgehog (SHH) signaling, GLI family zinc finger (

126 Patched 1 (PTCH1), an inhibitor of sonic hedgehog (SHH) signaling, harbored an enrichment o

127 ons causing EvC dwarfism do so by disrupting sonic hedgehog (Shh) signaling, our data implicate Shh s

128 ing progenitors at higher or lower levels of sonic hedgehog (Shh) signaling, respectively.

129 Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH subgroup MB (SHH-MB)

130 In the ventral neural tube, sonic hedgehog (Shh) signaling, together with broadly ex

131 ry G-protein coupled receptor that regulates Sonic Hedgehog (Shh) signaling.

132 an expression profile consistent with active Sonic Hedgehog (SHH) signaling.

133 for Gli-mediated transcription activation in Sonic hedgehog (Shh) signaling.

134 calizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling.

135 pattern of apical constriction controlled by Sonic hedgehog (Shh) signaling.

136 ored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling.

137 tigate local temporospatial requirements for sonic hedgehog (SHH) signalling during tongue developmen

138 al model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in the chick wing bud sp

139 Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick w

140 revious studies found that astrocyte-derived Sonic hedgehog (SHH) stabilizes the BBB during CNS infla

141 In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant

142 identification of key tumorigenic events in Sonic Hedgehog (SHH) subgroup medulloblastomas (MBSHH) w

143 Yin et al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SU

144 Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of medulloblastoma, here w

145 (TAMs), which are abundantly present in the Sonic Hedgehog (SHH) subgroup of medulloblastoma.

146 TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1.

147 During development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM

148 anching area, along with a downregulation of sonic hedgehog (Shh) transcription, but not in the equal

149 abolishes the growth stimulation effects of sonic hedgehog (SHH) treatment, resulting in the disrupt

150 pc(Min) mice were crossed with mice in which sonic hedgehog (SHH) was overexpressed specifically in t

151 Sponges loaded with lentivirus encoding for Sonic hedgehog (Shh) were investigated for acute (delive

152 he embryonic vertebrate limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the act

153 We hypothesized that sonic hedgehog (Shh), a secreted intestinal epithelial p

154 Sonic hedgehog (Shh), a soluble ligand overexpressed by

155 of a novel gene expression program involving sonic hedgehog (Shh), activated de novo in injured nerve

156 Sonic hedgehog (SHH), an activating ligand of smoothened

157 We also found that tumor cells secrete sonic hedgehog (SHH), an Hh ligand, and that tumor-deriv

158 IPL1 cellular localization, interaction with sonic hedgehog (SHH), and influence on hedgehog signalin

159 Remarkably, p63 regulates the expression of Sonic Hedgehog (Shh), GLI family zinc finger 2 (Gli2), a

160 ur subgroups of MB have been described (WNT, sonic hedgehog (SHH), Group 3 and Group 4), each of whic

161 subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group 4-in the daily

162 ubgroups of medulloblastoma: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4.

163 The activating ligand, Sonic hedgehog (SHH), is highly hydrophobic because of d

164 omprised largely of netrin1 (FP-netrin1) and Sonic hedgehog (Shh), that can attract the axons at a di

165 Here, we show that Sonic hedgehog (Shh), which encodes a secreted protein s

166 emethylation of H3K27 in many genes, such as Sonic hedgehog (Shh), which is silenced throughout Schwa

167 activation of fibroblasts was identified as sonic hedgehog (Shh), which was rapidly induced in renal

168 e transforming growth factor-beta (Tgfbeta), sonic hedgehog (Shh), wingless-integrated site (Wnt)/bet

169 d TME evolution at single-cell resolution in sonic hedgehog (SHH)-activated medulloblastomas that ori

170 ded cyclic peptide was designed based on the sonic hedgehog (Shh)-binding loop of hedgehog-interactin

171 es in SLOS resemble those seen in congenital Sonic Hedgehog (SHH)-deficient conditions, leading to th

172 t low levels, defines a subset of aggressive Sonic hedgehog (SHH)-driven human medulloblastomas.

173 from patched (Ptch) mutant mice, a model of Sonic hedgehog (SHH)-driven MB.

174 loblastoma reveals MET kinase as a marker of sonic hedgehog (SHH)-driven medulloblastoma.

175 describe a cell cycle timer that operates in Sonic hedgehog (Shh)-expressing polarising region cells

176 Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial ne

177 We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates

178 Transplantation of Sonic hedgehog (Shh)-soaked beads at the ventricular bas

179 Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression

180 C), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patie

181 with long-term survival as low as 50-60% for Sonic Hedgehog (Shh)-type medulloblastoma.

182 mid1 expression, controlled by the morphogen Sonic hedgehog (Shh).

183 highly conserved long-range limb enhancer of Sonic hedgehog (Shh).

184 brain development via the secreted morphogen Sonic hedgehog (Shh).

185 nding sites in the limb-specific enhancer of Sonic hedgehog (SHH).

186 rating dermal adipogenesis through secreting Sonic Hedgehog (SHH).

187 acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh).

188 ity emerges through the morphogen actions of Sonic hedgehog (Shh).

189 oylated N-terminal signaling domain of human Sonic hedgehog (ShhN(p)) at a 4:2 stoichiometric ratio.

190 ent between molecular subgroups (WNT, n = 4; sonic hedgehog [SHH; n = 4]; group 4 [n = 41]; group 3 w

191 tility of Zwitch, we generated a conditional sonic hedgehog a (shha) allele.

192 This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian he

193 ecular subgroup of HCA with beta-catenin and sonic hedgehog activation associated with malignant tran

194 ET subgroups, indicating they resemble human Sonic hedgehog and group 3 and 4 medulloblastoma and CNS

195 m hair bulge explants, manipulating the WNT, sonic hedgehog and TGFbeta signalling pathways, and expo

196 a short palmitoylated N-terminal fragment of Sonic Hedgehog binds Patched1 and, strikingly, is suffic

197 The rest of Sonic Hedgehog confers high-affinity Patched1 binding an

198 eous formation of new HFs and an increase in Sonic Hedgehog expression resembling wild-type mice at P

199 llbladder also showed a drastic reduction in sonic hedgehog expression, leading to aberrant smooth mu

200 udying the enhancer-driven activation of the Sonic hedgehog gene (Shh), we have identified a change i

201 yos, which might be explained by the reduced Sonic hedgehog in embryos.

202 Palmitoylated sonic Hedgehog is found in the endoplasmic reticulum, th

203 validated model for timing under control of Sonic Hedgehog is revisited and generalized to an arbitr

204 Overexpression of sonic hedgehog ligand (SHH) in infected WT mice accelera

205 ct, palmitate-dependent interaction with the Sonic Hedgehog ligand.

206 Using sonic hedgehog lineage tracing, we show that the third a

207 tations were exclusively associated with the sonic hedgehog medulloblastoma (MB(SHH)) subgroup and ac

208 The Sonic Hedgehog medulloblastoma subgroup transcriptionall

209 Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes a

210 fferential adhesion code is regulated by the sonic hedgehog morphogen gradient.

211 with Patched1 is specifically impaired in a Sonic Hedgehog mutant causing human holoprosencephaly, t

212 re was significantly lower mRNA abundance of sonic hedgehog pathway elements at P0 vs E12.5, while ab

213 regulates the transcriptional events of the sonic hedgehog pathway genes that are implicated in almo

214 nstream location of the SUFU gene within the sonic hedgehog pathway may explain why its loss is assoc

215 f the INHBE and GLI1 genes and activation of sonic hedgehog pathway.

216 n of Gli1, a transcriptional effector of the sonic hedgehog pathway.

217 s pointing to wnt/beta-catenin, TGF-beta and sonic hedgehog pathways.

218 N identity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord.

219 trated that the OLFM4 protein interacts with sonic hedgehog protein, as well as significantly inhibit

220 ule cells and interneurons via the amount of sonic hedgehog secreted.

221 Notably, sonic hedgehog signaling activity influences clonal spat

222 We present mouse models of sonic hedgehog signaling and craniofacial malformations

223 in haired animals; however, the magnitude of sonic hedgehog signaling did not differ significantly.

224 Restoration using DDND treatment results in sonic hedgehog signaling down regulation, which decrease

225 Combined early activation of sonic hedgehog signaling followed by timed NOTCH inhibit

226 ally and examine these models in relation to Sonic Hedgehog signaling in the vertebrate central nervo

227 Sonic Hedgehog signaling is critical for breast morphoge

228 e mice at P0, thereby indicating that the HS/Sonic Hedgehog signaling pathway regulates HF formation

229 s replicating alpha-cell exhibited activated Sonic hedgehog signaling, a pathway not previously known

230 aired function, as indicated by dysregulated sonic hedgehog signaling, abnormal staining for IFT-B co

231 e tumors were characterized by activation of sonic hedgehog signaling, due to focal deletions that fu

232 f purmorphamine, a small-molecule agonist of sonic hedgehog signaling, hPSCs were differentiated to d

233 mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly.

234 levels, facilitates ciliogenesis and alters Sonic Hedgehog signaling, pointing to a key role in cyto

235 ligands for gp130, interleukin 6, cytokines, sonic hedgehog signaling, STAT3 phosphorylation (activat

236 ocalization for key signaling events such as sonic hedgehog signaling.

237 but in the absence of factors that activate sonic hedgehog signaling.

238 of the zebrafish neural tube in response to Sonic Hedgehog signaling.

239 cilia architecture, protein trafficking and Sonic hedgehog signaling.

240 S9 resulted in shortened cilia and defective sonic hedgehog signaling.

241 Finally, in vivo inhibition of sonic hedgehog signalling in Eda null teeth enabled us t

242 lling functions, including growth factor and Sonic hedgehog signalling.

243 Our data demonstrate that Sonic Hedgehog signals via the palmitate-dependent arm o

244 mising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma.

245 essor gene Ptch1 and a recapitulation of the sonic hedgehog subgroup of human medulloblastomas.

246 (TAMs) can promote tumor progression in the sonic hedgehog subgroup of medulloblastoma (SHH-MB).

247 ile having little effect on mouse MBs of the sonic hedgehog subgroup.

248 The sonic hedgehog subtype of medulloblastoma (SHH MB) is as

249 ic brain tumor with five molecular subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype

250 ecular subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype, WNT, Group 3, and Group 4,

251 s, this was due to the overexpression of the sonic hedgehog transcription factor Gli1, which elevated

252 protein encoded by DYRK1B inhibits the SHH (sonic hedgehog) and Wnt signaling pathways and consequen

253 ecules (including Osterix, beta-catenin, and sonic hedgehog) that play a critical role in root format

254 De novo variants were identified in SHH (Sonic Hedgehog), and inherited variants were identified

255 SHH (Sonic Hedgehog)-GLI signaling plays an important role du

256 Signaling pathways (retinoic acid, sonic hedgehog, and Notch) that pattern the neural tube

257 on of multiple signaling pathways, including Sonic hedgehog, bone morphogenetic protein, fibroblast g

258 by several transcriptional factors, such as sonic hedgehog, fibroblast growth factors, and wingless-

259 rmal integrin beta1 and include Wnt, but not sonic hedgehog, signaling.

260 ic palmitoylated proteins, as exemplified by sonic Hedgehog, tubulin, and Ras.

261 After establishment by sonic hedgehog, ventral NSC identity became independent

262 a posttranslational mechanism, regulated by Sonic hedgehog, which is important to suppress Pax6 acti

263 DNA methylation profiles of infantile sonic hedgehog-activated medulloblastoma (SHH-INF) were

264 unction experiments do not support a role in sonic hedgehog-dependent signaling, but reveal a disrupt

265 ts demonstrate an unexpected role for ASC in Sonic hedgehog-driven medulloblastoma tumorigenesis, thu

266 ogenitors derived from hESCs and hiPSCs in a sonic hedgehog-independent manner.

267 Sonic Hedgehog-overexpressing tumors express PTCH-induce

268 ne demonstrated dose-dependent inhibition of sonic hedgehog-patched-gli signaling.

269 s recently highlighted an important role for Sonic hedgehog-positive cells and retinoid signaling tha

270 nsive discussion on how Wnt/beta-catenin and sonic hedgehog-Smoothened signaling mechanisms control t

271 ng on a long-distance cis-acting enhancer of Sonic Hedgehog.

272 medulloblastoma subtypes driven by aberrant Sonic Hedgehog/Patched (SHH/PTCH) signaling.

273 , providing the most potent inhibitor of the sonic hedgehog/patched interaction reported to date.

274 In contrast, potent inhibitors of the sonic hedgehog/patched interaction, the most upstream ev

275 ressing versus -silenced PC cells identified Sonic-hedgehog (SHH) and Adrenomedullin (ADM) as two dif

276 ibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB).

277 frequently mutated in the Wingless (WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma-the comm

278 Sonic Hh (Shh) ligand-producing cells and Shh-responsive

279 y, Hh inhibitors have the potential to treat sonic Hh driven MB (SHH-MB), but their repeated use deve

280 SONICS is a phase 3, multicentre, open-label, non-random

281 ed by spot number and intensity correlation (SONIC), is fully automated, robust to noise, and does no

282 The Sonic Kayak is a musical instrument used to investigate

283 We describe here the sonic mechanism and sounds in two species of boxfish, th

284 The sonic mechanism utilizes a T-shaped swimbladder with a s

285 D structure of the Z-band in the swimbladder sonic muscle of type I male plainfin midshipman fish (Po

286 with a swimbladder fenestra and two separate sonic muscle pairs.

287 d aponeuroses (flat tendons that connect the sonic muscles to the swim bladder) in this and other sci

288 A rich sonic palette is created by controlling the composition

289 ks significantly, thus modifying seismic and sonic responses to shaley sequences.

290 f discomfort for air-polishing compared with sonic scaling (test 2.33 +/- 2.14, control 4.91 +/- 2.65

291 Sonic scaling evoked more discomfort compared with air-p

292 owder showed comparable clinical outcomes to sonic scaling.

293 g the maximum linear velocity well below the sonic speed and material breakdown limit.

294 ar MS in the form of desorption easy ambient sonic spray ionization (EASI) -MS was used to rapidly pr

295 ent in a mechanism similar to thermospray or sonic spray ionization.

296 electrospray ionization (DESI), easy ambient sonic-spray ionization (EASI) and low-temperature plasma

297 ctrospray ionization (DESI) and easy ambient sonic-spray ionization (EASI) with well-defined selectiv

298 lary was connected to a Venturi easy ambient sonic-spray ionization source, sampling the resulting an

299 In addition, sonic velocities are consistent with the presence of gas

300 and introduce energy via the dissipation of sonic waves.