ライフサイエンスコーパス: sonic hedgehog

1 ng on a long-distance cis-acting enhancer of Sonic Hedgehog.

2 er resting conditions but not in response to Sonic Hedgehog.

3 tility of Zwitch, we generated a conditional sonic hedgehog a (shha) allele.

4 This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian he

5 DNA methylation profiles of infantile sonic hedgehog-activated medulloblastoma (SHH-INF) were

6 ecular subgroup of HCA with beta-catenin and sonic hedgehog activation associated with malignant tran

7 tors of these interneurons are responsive to sonic hedgehog and are organized into microdomains that

8 5H3 (unc5H3), doublecortin, cyclo-oxygenase, sonic hedgehog and Disrupted in schizophrenia-1 (DISC1),

9 ET subgroups, indicating they resemble human Sonic hedgehog and group 3 and 4 medulloblastoma and CNS

10 ly committed sclerotome from somite requires sonic hedgehog and Nog.

11 m hair bulge explants, manipulating the WNT, sonic hedgehog and TGFbeta signalling pathways, and expo

12 protein encoded by DYRK1B inhibits the SHH (sonic hedgehog) and Wnt signaling pathways and consequen

13 De novo variants were identified in SHH (Sonic Hedgehog), and inherited variants were identified

14 Signaling pathways (retinoic acid, sonic hedgehog, and Notch) that pattern the neural tube

15 totic cells that have been dorsalized by the sonic hedgehog antagonist cyclopamine, and that express,

16 a short palmitoylated N-terminal fragment of Sonic Hedgehog binds Patched1 and, strikingly, is suffic

17 development have been identified, including sonic hedgehog, bone morphogenetic protein 4 and multipl

18 on of multiple signaling pathways, including Sonic hedgehog, bone morphogenetic protein, fibroblast g

19 The rest of Sonic Hedgehog confers high-affinity Patched1 binding an

20 unction experiments do not support a role in sonic hedgehog-dependent signaling, but reveal a disrupt

21 ts demonstrate an unexpected role for ASC in Sonic hedgehog-driven medulloblastoma tumorigenesis, thu

22 ibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB).

23 eous formation of new HFs and an increase in Sonic Hedgehog expression resembling wild-type mice at P

24 llbladder also showed a drastic reduction in sonic hedgehog expression, leading to aberrant smooth mu

25 ta-catenin signaling in the cells and to add Sonic hedgehog, FGF10, and thymosin beta4.

26 by several transcriptional factors, such as sonic hedgehog, fibroblast growth factors, and wingless-

27 udying the enhancer-driven activation of the Sonic hedgehog gene (Shh), we have identified a change i

28 SHH (Sonic Hedgehog)-GLI signaling plays an important role du

29 was reduced at multiple stages, whereas the Sonic hedgehog (Hh [Shh])-deficient FL showed increased

30 BCC is primarily driven by the Sonic Hedgehog (Hh) pathway.

31 he lysine-II&V/phenylalanine degradation and sonic hedgehog (Hh) pathways in reversible TMZ-effect ce

32 pression of genes encoding components of the Sonic Hedgehog (Hh) signaling pathway, a driver of mamma

33 yos, which might be explained by the reduced Sonic hedgehog in embryos.

34 tebrates is its co-localisation with that of Sonic hedgehog in the floor plate of the neural tube.

35 ogenitors derived from hESCs and hiPSCs in a sonic hedgehog-independent manner.

36 Palmitoylated sonic Hedgehog is found in the endoplasmic reticulum, th

37 validated model for timing under control of Sonic Hedgehog is revisited and generalized to an arbitr

38 Overexpression of sonic hedgehog ligand (SHH) in infected WT mice accelera

39 ct, palmitate-dependent interaction with the Sonic Hedgehog ligand.

40 Using sonic hedgehog lineage tracing, we show that the third a

41 c patients with the medulloblastoma subgroup Sonic Hedgehog (MB(SHH))(.) ELP1 was the most common med

42 tations were exclusively associated with the sonic hedgehog medulloblastoma (MB(SHH)) subgroup and ac

43 The Sonic Hedgehog medulloblastoma subgroup transcriptionall

44 Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes a

45 fferential adhesion code is regulated by the sonic hedgehog morphogen gradient.

46 with Patched1 is specifically impaired in a Sonic Hedgehog mutant causing human holoprosencephaly, t

47 y-acylated protein of interest, such as Wnt, Sonic Hedgehog or H-Ras.

48 minence progenitors by simple treatment with sonic hedgehog or its agonist purmorphamine over the nex

49 Sonic Hedgehog-overexpressing tumors express PTCH-induce

50 ne demonstrated dose-dependent inhibition of sonic hedgehog-patched-gli signaling.

51 medulloblastoma subtypes driven by aberrant Sonic Hedgehog/Patched (SHH/PTCH) signaling.

52 , providing the most potent inhibitor of the sonic hedgehog/patched interaction reported to date.

53 In contrast, potent inhibitors of the sonic hedgehog/patched interaction, the most upstream ev

54 re was significantly lower mRNA abundance of sonic hedgehog pathway elements at P0 vs E12.5, while ab

55 regulates the transcriptional events of the sonic hedgehog pathway genes that are implicated in almo

56 nstream location of the SUFU gene within the sonic hedgehog pathway may explain why its loss is assoc

57 f the INHBE and GLI1 genes and activation of sonic hedgehog pathway.

58 n of Gli1, a transcriptional effector of the sonic hedgehog pathway.

59 s pointing to wnt/beta-catenin, TGF-beta and sonic hedgehog pathways.

60 N identity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord.

61 s recently highlighted an important role for Sonic hedgehog-positive cells and retinoid signaling tha

62 trated that the OLFM4 protein interacts with sonic hedgehog protein, as well as significantly inhibit

63 ule cells and interneurons via the amount of sonic hedgehog secreted.

64 Furthermore, we provide evidence that Sonic hedgehog (Shh) activates Gli2 by stimulating its p

65 Aberrant Sonic hedgehog (Shh) activation during adulthood leads t

66 ane, boosting cell sensitivity to the ligand Sonic Hedgehog (SHH) and consequently altering SHH-guide

67 Sonic hedgehog (SHH) and fibroblast growth factor (FGF)

68 Here, we investigated how Sonic hedgehog (Shh) and Fibroblast growth factor (Fgf)

69 sor cells, which express the secreted factor sonic hedgehog (Shh) and give rise to taste bud cells th

70 ed subgroup of medulloblastoma, is driven by Sonic hedgehog (Shh) and insulin-like growth factor (IGF

71 causes derepression of several genes, e.g., Sonic hedgehog (Shh) and Insulin-like growth factor-bind

72 The presence of Sonic Hedgehog (Shh) and its signaling components in the

73 However, the source of Hh ligand sonic hedgehog (SHH) and its target cells remains contro

74 (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of th

75 Sonic hedgehog (Shh) and retinoic acid (RA) signaling is

76 Sonic hedgehog (Shh) and Sca1, markers of aortic osteoge

77 Signaling networks controlled by Sonic hedgehog (SHH) and the transcription factor Atoh1

78 be (central nervous system, CNS), depends on Sonic hedgehog (SHH) as a main signaling morphogen.

79 ich constitute the core reception system for sonic hedgehog (SHH) as well as GLI transcription factor

80 Sonic hedgehog (Shh) attracts spinal cord commissural ax

81 HS production around the lesion allows Sonic hedgehog (Shh) binding and favors the local enrich

82 The secreted Hedgehog ligand Sonic Hedgehog (SHH) binds to its receptor Patched1 (PTC

83 Epithelial-specific deletion of sonic hedgehog (Shh) during postnatal homeostasis in the

84 re able to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 an

85 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic patter

86 We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin, and Hh pathway

87 Sonic hedgehog (Shh) expression in the limb bud organizi

88 nitial presence in the cancer cell of origin Sonic hedgehog (Shh) expression is invariably lost durin

89 in conjunction with FoxA2, directly induces Sonic hedgehog (Shh) expression through binding to a Shh

90 In Ftm (-/-) embryos, Sonic hedgehog (Shh) expression was virtually lost in th

91 his region were observed including decreased Sonic hedgehog (Shh) expression, abnormal cell adhesion,

92 of the chick limb bud times the duration of Sonic hedgehog (Shh) expression, which encodes the morph

93 anisms, consisting of iterative signaling by Sonic hedgehog (SHH) followed by Bone morphogenetic prot

94 ), and that gustatory nerves are a source of sonic hedgehog (Shh) for taste bud renewal.

95 demonstrate a requirement for the Hh ligand Sonic Hedgehog (Shh) for the progression of SCLC.

96 Loss of expression of Sonic Hedgehog (Shh) from parietal cells results in hype

97 All tumor samples clustered within the sonic hedgehog (SHH) group.

98 ling in axon guidance.SIGNIFICANCE STATEMENT Sonic hedgehog (Shh) guides axons via a noncanonical sig

99 Sonic hedgehog (Shh) has been suggested to promote the f

100 Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been

101 n Barrett's metaplasia and overexpression of Sonic hedgehog (SHH) in mouse esophageal squamous epithe

102 a perineural microenvironment, and deleting Sonic hedgehog (Shh) in neurons or Smoothened in the epi

103 tion and histone modification, is induced by Sonic Hedgehog (SHH) in SHH-dependent cerebellar progeni

104 Six2creFrs2alphaKO interstitium and ectopic sonic hedgehog (Shh) in subsets of non-dilated P7 mutant

105 e in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two s

106 We showed that gigaxonin governs Sonic Hedgehog (Shh) induction, the developmental pathwa

107 The distribution of Sonic Hedgehog (Shh) is a highly regulated and critical

108 Sonic hedgehog (Shh) is a mitogen for spinal cord progen

109 Sonic hedgehog (Shh) is a morphogenic protein that opera

110 Sonic hedgehog (Shh) is a multifunctional signaling prot

111 Sonic hedgehog (Shh) is a secreted protein that controls

112 Sonic Hedgehog (Shh) is abnormally expressed in pancreat

113 Sonic hedgehog (SHH) is an essential morphogenetic signa

114 Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fa

115 The signaling protein Sonic Hedgehog (SHH) is crucial for the development and

116 Yao and colleagues report that the morphogen sonic hedgehog (Shh) is driven by platelet-derived growt

117 Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patte

118 In the early limb bud, for instance, Sonic hedgehog (Shh) is expressed in the distal posterio

119 The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal meso

120 Sonic Hedgehog (Shh) is normally present in the axons of

121 ion of three key components that include the sonic hedgehog (Shh) ligand, its receptor patched 1 (Ptc

122 pment and cancer: it covalently modifies the Sonic hedgehog (SHH) ligand, restricting its release fro

123 n progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively.

124 Zeb1 expression is elevated in the Sonic Hedgehog (SHH) medulloblastoma subgroup originatin

125 Sonic Hedgehog (SHH) medulloblastomas are brain tumours

126 velopmental hierarchy of progenitor pools in Sonic Hedgehog (SHH) medulloblastomas, and identified OL

127 small nuclear RNAs (snRNAs) in about 50% of Sonic hedgehog (SHH) medulloblastomas.

128 ere treated with Smoothened Agonist (SAG), a Sonic Hedgehog (Shh) mimetic in order to fortify blood b

129 The CXCR4 chemokine and Sonic Hedgehog (SHH) morphogen pathways are well-validat

130 tiation, causing limb defects that phenocopy Sonic Hedgehog (Shh) mutants.

131 During embryogenesis, sonic hedgehog (SHH) negatively regulates taste bud patt

132 Stimulation with Sonic Hedgehog (Shh) of primary mammary mesenchymal cell

133 h ectopic expression of the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with

134 ry cilium to promote Smo phosphorylation and Sonic hedgehog (Shh) pathway activation.

135 Treatment with the Sonic hedgehog (Shh) pathway agonist purmorphamine or cy

136 ntified in genes involving regulation of the sonic hedgehog (Shh) pathway in 14/38 individuals (37%).

137 s result in transcriptomic activation of the Sonic Hedgehog (SHH) pathway in SSTs.

138 Stimulation of the sonic hedgehog (Shh) pathway in vertebrates results in a

139 udies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smooth

140 The Sonic Hedgehog (SHH) pathway is a key signaling pathway

141 We found that a noncanonical Sonic Hedgehog (Shh) pathway is rapidly activated in res

142 SCLC) often features the upregulation of the Sonic hedgehog (Shh) pathway leading to activation of Gl

143 The Sonic Hedgehog (SHH) pathway plays a key role in cancer.

144 (REST) is increased in tumors driven by the sonic hedgehog (SHH) pathway, specifically the SHH-alpha

145 ntiation; and RGS5, decay of which activates Sonic Hedgehog (SHH) pathway-mediated differentiation of

146 is controlled by hormonal regulation of the Sonic hedgehog (Shh) pathway.

147 y, and IGF-1 expression was regulated by the Sonic Hedgehog (Shh) pathway.

148 s et al. implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb.

149 Using Sonic hedgehog (Shh) patterning of the ventral neural tu

150 Sonic hedgehog (SHH) plays a central role in patterning

151 thelial buds and suppress epithelial-derived sonic hedgehog (SHH) production.

152 Here, we present a system to trigger a Sonic Hedgehog (SHH) protein gradient in developing fore

153 patient carrying a germline mutation in the sonic hedgehog (SHH) receptor PTCH1.

154 egulation of the Ptch1 gene, which encodes a Sonic hedgehog (SHH) receptor, is disrupted specifically

155 oding a transmembrane protein related to the Sonic hedgehog (Shh) receptor, Patched, and involved in

156 c hippocampal neurons in which activation of Sonic Hedgehog (Shh) receptors in dendrites stimulates a

157 Sonic Hedgehog (SHH) reduces ciliary cAMP levels, inhibi

158 We provide evidence here that sonic hedgehog (Shh) secreted from the gut epithelium pr

159 Sonic hedgehog (Shh) signal transduction specifies ventr

160 Sonic hedgehog (Shh) signal transduction was downregulat

161 s and has been hypothesized to contribute to Sonic hedgehog (Shh) signaling and synapse formation.

162 m elongation, Smo ciliary translocation, and Sonic Hedgehog (Shh) signaling and ultimately impair emb

163 n the present study, we uncovered a role for sonic hedgehog (SHH) signaling during lip fusion.

164 We found that constitutively active Sonic hedgehog (Shh) signaling expanded bRGs and IPCs an

165 for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven

166 Here, we show that Sonic hedgehog (Shh) signaling in mature astrocytes is r

167 helia and underlying stroma due to paracrine Sonic hedgehog (SHH) signaling in producing desmoplasia

168 Normally, sonic hedgehog (Shh) signaling induces high levels of Pa

169 In the healthy, adult CNS, Sonic hedgehog (Shh) signaling is active in mature, diff

170 l) mice were used to establish that impaired Sonic hedgehog (Shh) signaling is associated with loss o

171 Sonic hedgehog (Shh) signaling is critical in developmen

172 Although sonic hedgehog (SHH) signaling is known to activate CGNP

173 In the developing cerebellum, Sonic hedgehog (SHH) signaling is required for expansion

174 t, in hippocampal neurons, activation of the Sonic hedgehog (Shh) signaling pathway affects multiple

175 through changes in genes associated with the sonic hedgehog (SHH) signaling pathway, required for spa

176 oma are driven by aberrant activation of the Sonic Hedgehog (SHH) signaling pathway.

177 T and predicts the activation of the Wnt and Sonic hedgehog (SHH) signaling pathways during this proc

178 Sonic hedgehog (Shh) signaling patterns the vertebrate s

179 We report herein that sonic hedgehog (Shh) signaling plays a key role in catar

180 Mutations in Sonic hedgehog (SHH) signaling promote aberrant prolifer

181 ant rescued mandibular morphogenesis through sonic hedgehog (SHH) signaling to the mesenchyme.

182 own of Stil gene expression or inhibition of Sonic hedgehog (Shh) signaling transduction decreases th

183 Reduced sonic hedgehog (SHH) signaling was confirmed by in situ

184 PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regu

185 when maintained in a proliferative state by sonic hedgehog (Shh) signaling, and Aspm is expressed in

186 granule neuron precursors (CGNPs) induced by Sonic Hedgehog (SHH) signaling, but downstream effectors

187 In Sonic hedgehog (SHH) signaling, GLI family zinc finger (

188 Patched 1 (PTCH1), an inhibitor of sonic hedgehog (SHH) signaling, harbored an enrichment o

189 ons causing EvC dwarfism do so by disrupting sonic hedgehog (Shh) signaling, our data implicate Shh s

190 ing progenitors at higher or lower levels of sonic hedgehog (Shh) signaling, respectively.

191 Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH subgroup MB (SHH-MB)

192 In the ventral neural tube, sonic hedgehog (Shh) signaling, together with broadly ex

193 an expression profile consistent with active Sonic Hedgehog (SHH) signaling.

194 for Gli-mediated transcription activation in Sonic hedgehog (Shh) signaling.

195 calizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling.

196 pattern of apical constriction controlled by Sonic hedgehog (Shh) signaling.

197 red ciliogenesis with concomitant defects in sonic hedgehog (SHH) signaling.

198 ored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling.

199 ry G-protein coupled receptor that regulates Sonic Hedgehog (Shh) signaling.

200 tigate local temporospatial requirements for sonic hedgehog (SHH) signalling during tongue developmen

201 al model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in the chick wing bud sp

202 Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick w

203 The Sonic hedgehog (Shh) signalling pathway plays important

204 revious studies found that astrocyte-derived Sonic hedgehog (SHH) stabilizes the BBB during CNS infla

205 clear genetically defined subclasses of the sonic hedgehog (SHH) subclass of medulloblastoma.

206 In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant

207 identification of key tumorigenic events in Sonic Hedgehog (SHH) subgroup medulloblastomas (MBSHH) w

208 Yin et al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SU

209 Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of medulloblastoma, here w

210 (TAMs), which are abundantly present in the Sonic Hedgehog (SHH) subgroup of medulloblastoma.

211 TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1.

212 During development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM

213 anching area, along with a downregulation of sonic hedgehog (Shh) transcription, but not in the equal

214 abolishes the growth stimulation effects of sonic hedgehog (SHH) treatment, resulting in the disrupt

215 pc(Min) mice were crossed with mice in which sonic hedgehog (SHH) was overexpressed specifically in t

216 Sponges loaded with lentivirus encoding for Sonic hedgehog (Shh) were investigated for acute (delive

217 he embryonic vertebrate limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the act

218 We hypothesized that sonic hedgehog (Shh), a secreted intestinal epithelial p

219 Sonic hedgehog (Shh), a soluble ligand overexpressed by

220 of a novel gene expression program involving sonic hedgehog (Shh), activated de novo in injured nerve

221 Sonic hedgehog (SHH), an activating ligand of smoothened

222 We also found that tumor cells secrete sonic hedgehog (SHH), an Hh ligand, and that tumor-deriv

223 IPL1 cellular localization, interaction with sonic hedgehog (SHH), and influence on hedgehog signalin

224 Remarkably, p63 regulates the expression of Sonic Hedgehog (Shh), GLI family zinc finger 2 (Gli2), a

225 ur subgroups of MB have been described (WNT, sonic hedgehog (SHH), Group 3 and Group 4), each of whic

226 subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group 4-in the daily

227 ubgroups of medulloblastoma: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4.

228 The activating ligand, Sonic hedgehog (SHH), is highly hydrophobic because of d

229 es (CRMs) associated with genes regulated by Sonic hedgehog (Shh), retinoids, or bone morphogenetic p

230 omprised largely of netrin1 (FP-netrin1) and Sonic hedgehog (Shh), that can attract the axons at a di

231 Here, we show that Sonic hedgehog (Shh), which encodes a secreted protein s

232 emethylation of H3K27 in many genes, such as Sonic hedgehog (Shh), which is silenced throughout Schwa

233 activation of fibroblasts was identified as sonic hedgehog (Shh), which was rapidly induced in renal

234 e transforming growth factor-beta (Tgfbeta), sonic hedgehog (Shh), wingless-integrated site (Wnt)/bet

235 d TME evolution at single-cell resolution in sonic hedgehog (SHH)-activated medulloblastomas that ori

236 ded cyclic peptide was designed based on the sonic hedgehog (Shh)-binding loop of hedgehog-interactin

237 es in SLOS resemble those seen in congenital Sonic Hedgehog (SHH)-deficient conditions, leading to th

238 t low levels, defines a subset of aggressive Sonic hedgehog (SHH)-driven human medulloblastomas.

239 from patched (Ptch) mutant mice, a model of Sonic hedgehog (SHH)-driven MB.

240 loblastoma reveals MET kinase as a marker of sonic hedgehog (SHH)-driven medulloblastoma.

241 describe a cell cycle timer that operates in Sonic hedgehog (Shh)-expressing polarising region cells

242 Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial ne

243 We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates

244 Transplantation of Sonic hedgehog (Shh)-soaked beads at the ventricular bas

245 Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression

246 C), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patie

247 with long-term survival as low as 50-60% for Sonic Hedgehog (Shh)-type medulloblastoma.

248 mid1 expression, controlled by the morphogen Sonic hedgehog (Shh).

249 highly conserved long-range limb enhancer of Sonic hedgehog (Shh).

250 brain development via the secreted morphogen Sonic hedgehog (Shh).

251 nding sites in the limb-specific enhancer of Sonic hedgehog (SHH).

252 rating dermal adipogenesis through secreting Sonic Hedgehog (SHH).

253 acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh).

254 ity emerges through the morphogen actions of Sonic hedgehog (Shh).

255 iferate after TACs form and begin expressing Sonic Hedgehog (SHH).

256 entate are controlled by distinct sources of Sonic Hedgehog (Shh).

257 ressing versus -silenced PC cells identified Sonic-hedgehog (SHH) and Adrenomedullin (ADM) as two dif

258 ent between molecular subgroups (WNT, n = 4; sonic hedgehog [SHH; n = 4]; group 4 [n = 41]; group 3 w

259 oylated N-terminal signaling domain of human Sonic hedgehog (ShhN(p)) at a 4:2 stoichiometric ratio.

260 Notably, sonic hedgehog signaling activity influences clonal spat

261 We present mouse models of sonic hedgehog signaling and craniofacial malformations

262 in haired animals; however, the magnitude of sonic hedgehog signaling did not differ significantly.

263 Restoration using DDND treatment results in sonic hedgehog signaling down regulation, which decrease

264 Combined early activation of sonic hedgehog signaling followed by timed NOTCH inhibit

265 ally and examine these models in relation to Sonic Hedgehog signaling in the vertebrate central nervo

266 Sonic Hedgehog signaling is critical for breast morphoge

267 e mice at P0, thereby indicating that the HS/Sonic Hedgehog signaling pathway regulates HF formation

268 s replicating alpha-cell exhibited activated Sonic hedgehog signaling, a pathway not previously known

269 aired function, as indicated by dysregulated sonic hedgehog signaling, abnormal staining for IFT-B co

270 e tumors were characterized by activation of sonic hedgehog signaling, due to focal deletions that fu

271 f purmorphamine, a small-molecule agonist of sonic hedgehog signaling, hPSCs were differentiated to d

272 mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly.

273 levels, facilitates ciliogenesis and alters Sonic Hedgehog signaling, pointing to a key role in cyto

274 ligands for gp130, interleukin 6, cytokines, sonic hedgehog signaling, STAT3 phosphorylation (activat

275 ocalization for key signaling events such as sonic hedgehog signaling.

276 but in the absence of factors that activate sonic hedgehog signaling.

277 of the zebrafish neural tube in response to Sonic Hedgehog signaling.

278 cilia architecture, protein trafficking and Sonic hedgehog signaling.

279 S9 resulted in shortened cilia and defective sonic hedgehog signaling.

280 rmal integrin beta1 and include Wnt, but not sonic hedgehog, signaling.

281 Finally, in vivo inhibition of sonic hedgehog signalling in Eda null teeth enabled us t

282 lling functions, including growth factor and Sonic hedgehog signalling.

283 Our data demonstrate that Sonic Hedgehog signals via the palmitate-dependent arm o

284 ntles the primary cilium, known to transduce sonic-hedgehog signals, and is required for expression o

285 nsive discussion on how Wnt/beta-catenin and sonic hedgehog-Smoothened signaling mechanisms control t

286 t, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism t

287 mising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma.

288 essor gene Ptch1 and a recapitulation of the sonic hedgehog subgroup of human medulloblastomas.

289 (TAMs) can promote tumor progression in the sonic hedgehog subgroup of medulloblastoma (SHH-MB).

290 ile having little effect on mouse MBs of the sonic hedgehog subgroup.

291 The sonic hedgehog subtype of medulloblastoma (SHH MB) is as

292 ecules (including Osterix, beta-catenin, and sonic hedgehog) that play a critical role in root format

293 ic brain tumor with five molecular subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype

294 ecular subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype, WNT, Group 3, and Group 4,

295 s, this was due to the overexpression of the sonic hedgehog transcription factor Gli1, which elevated

296 We observe that the sonic hedgehog transcription factor glioma-associated pr

297 ic palmitoylated proteins, as exemplified by sonic Hedgehog, tubulin, and Ras.

298 ess to platelet-derived growth factor-AA and sonic hedgehog, two cilium-associated stimuli.

299 After establishment by sonic hedgehog, ventral NSC identity became independent

300 a posttranslational mechanism, regulated by Sonic hedgehog, which is important to suppress Pax6 acti