ライフサイエンスコーパス: sortilin

1 anism involving NTR1 and NTR3 (also known as sortilin).

2 her ATZ levels and secretion are affected by sortilin.

3 nt mannose-6-phosphate receptor (CI-MPR) and sortilin.

4 ortilin that impair lysosomal degradation of sortilin.

5 ation of proNGF interactions with p75NTR and sortilin.

6 nsulin-responsive aminopeptidase (IRAP), and sortilin.

7 R) receptors and cell death via p75(NTR) and Sortilin.

8 and required both p75NTR and its coreceptor sortilin.

9 ng to p75 neurotrophin receptor (p75NTR) and sortilin.

10 ed neurons, and recombinant proBDNF binds to sortilin.

11 ed cells by double transfection of Glut4 and sortilin.

12 er receptors macrophage mannose receptor and sortilin.

13 rest, cluster of differentiation 4 (CD4) and sortilin.

14 that physically interact and colocalize with sortilin.

15 he common neurotrophin receptor (p75NTR) and sortilin.

16 se 2-dependent C-terminal phosphorylation of sortilin.

17 at was independent of the endocytic receptor sortilin.

18 on, indicating a primary role of SMC-derived sortilin.

19 found that the cellular trafficking receptor sortilin 1 (Sort1) inhibits hepatic apolipoprotein B sec

20 Sortilin 1 (SORT1) is a lysosomal trafficking receptor t

21 The cellular trafficking receptor sortilin 1 (Sort1) was recently identified to transport

22 tional TDP-43 was measured by monitoring the sortilin 1 mRNA splicing activity.

23 Sortilin 1 regulates the levels of brain progranulin (PG

24 nd markedly increased expression of the gene sortilin-1 (SORT1) in liver.

25 sclerotic cardiovascular disease is the 1p13 sortilin-1 (SORT1) locus.

26 ssociated with altered expression of hepatic sortilin-1 (SORT1), which encodes a protein thought to b

27 led to amelioration of ER stress, increased sortilin-1 expression, and reduced apoB and triglyceride

28 icamycin led to marked repression of hepatic sortilin-1 expression, while administration of the chemi

29 ray identified reduced protein expression of sortilin-1 in liver and increased plasma enzyme activity

30 mRNA in ob/ob mice led to increased hepatic sortilin-1 levels and decreased apoB and triglyceride se

31 et models of obesity; restoration of hepatic sortilin-1 levels resulted in reduced triglyceride and a

32 mice reduced ER stress and increased hepatic sortilin-1 levels.

33 Furthermore, we identify sortilin-1(Sort1), a known regulator of circulating low-

34 orebrain-derived inhibitors, one of which is sortilin, a lysosomal sorting receptor.

35 This revealed that the protein is sortilin, a novel membrane protein that was cloned in an

36 n component of Glut4-containing vesicles, is sortilin, a novel type I receptor-like protein recently

37 Here we investigated whether sortilin, a Vps10p domain-sorting receptor believed to p

38 on of either p115 or CHC22, but not GM130 or sortilin, abrogates insulin-responsive GLUT4 release.

39 essure homeostasis after 14 days of systemic sortilin administration.

40 Understanding the mechanism by which sortilin affects LDL cholesterol will increase our under

41 Here we demonstrated that sortilin also directly affects atherogenesis, independen

42 bind beta-amyloid effector proteins such as sortilin and 14-3-3.

43 significantly reduces cell surface-expressed sortilin and abolishes proneurotrophin-induced neuronal

44 Both sortilin and BDNF are trafficked to and degraded by the

45 rotein consisting of the cytoplasmic tail of sortilin and EGFP is co-localized with ectopically expre

46 ilin and the cytoplasmic interaction between sortilin and GGA adaptors play an important role in recr

47 lin signaling but decreases the stability of sortilin and Glut4 and blocks their entry into the small

48 However, double expression of sortilin and Glut4 reconstitutes functional GSVs that in

49 Microglia express only the receptor 3 (NTR3)/sortilin and not the NTR1 or NTR2.

50 hypothesized that overexpression of proNGF, sortilin and p75(NTR) play a role in ts1-induced neurode

51 We found that complex formation between sortilin and p75(NTR) relies on contact points in the ex

52 To identify the interaction site between sortilin and p75(NTR), we analyzed binding between chime

53 l apoptosis using a dual receptor complex of sortilin and p75(NTR).

54 Here, we explore the expression of pro-NGF, sortilin and p75NTR in the mouse lumbar dorsal root gang

55 induce apoptosis of cells coexpressing both sortilin and p75NTR, suggesting that interaction of proB

56 In sympathetic neurons coexpressing sortilin and p75NTR, we found that proBDNF is an apoptot

57 that a subpopulation of neurons coexpresses sortilin and p75NTR.

58 strategies for brain-specific regulation of sortilin and possibly sortilin-driven pathologies.

59 , addition of preformed complexes of soluble sortilin and proBDNF failed to induce apoptosis of cells

60 levels of p75(NTR) and its interaction with sortilin and proNGF set the dependency on BDNF for survi

61 nd direct control of BDNF levels, while both sortilin and SorCS2 function as cell surface receptors t

62 Also, sortilin and SorLA both bind and mediate internalization

63 replicated the interaction between PGRN and sortilin and that between TNF and TNFRI/II, but not the

64 at the lumenal interaction between Glut4 and sortilin and the cytoplasmic interaction between sortili

65 mote apoptosis by engaging in a complex with sortilin and the p75 neurotrophin receptor (p75(NTR)).

66 The data provide a link between sortilin and the pathological findings of microglia and

67 a to disrupted interactions between PGRN and Sortilin and/or other binding partners yet to be identif

68 complexes with ERGIC tether p115, GLUT4, and sortilin, and downregulation of either p115 or CHC22, bu

69 SORT1 encodes a protein called sortilin, and hepatic sortilin modulates LDL metabolism

70 liver is independent of mannose 6-phosphate, sortilin, and Limp2.

71 ized storage vesicles containing IRAP, LRP1, sortilin, and VAMP2, which are sequestered by TUG, Ubc9,

72 We suggest that sortilin- and retromer-mediated Glut4 retrieval from end

73 In addition, sortilins are required for delivery of a key protease in

74 Our studies suggest a new function for sortilin as a modulator of BACE1 retrograde trafficking

75 We here identify sortilin as a novel APP interaction partner.

76 Together, our findings identified sortilin as an essential neuronal pathway for APOE-conta

77 we identified the pro-neurotrophin receptor sortilin as major endocytic pathway for clearance of APO

78 ether, these data reveal TrkA, p75(NTR), and sortilin as potential therapeutic targets in thyroid can

79 the non-neuronal isoforms, leaving SorLA and sortilin as the only receptors for sAPP generated by neu

80 Together, our findings establish sortilin, as a novel APP interaction partner that influe

81 etrograde transport of IRAP does not require sortilin, as retromer can directly bind to the cytoplasm

82 caused a 1.7-fold increase in the amount of sortilin at the plasma membranes of 3T3-L1 adipocytes, a

83 he life span of the Tg mice, suggesting that sortilin, at least in part, inhibits forebrain tau prion

84 on cellular coexpression of both p75NTR and sortilin, because neurons deficient in p75NTR are resist

85 as biosynthetic analysis, we discovered that sortilin binds and stabilizes APLP2, and hence could reg

86 Sortilin binds APOE with high affinity.

87 tent with a model in which increased hepatic sortilin binds intracellular APOB-containing particles i

88 However, sortilin binds to numerous ligands and plays a major rol

89 l loop of Glut4, and the cytoplasmic tail of sortilin binds to retromer.

90 ed apoptosis, and competitive antagonists of sortilin block sympathetic neuron death.

91 of the LDLR independently of either APLP2 or sortilin both ex vivo and in mice.

92 eriments reveal that the cytoplasmic tail of sortilin, but not those from other VPS10p domain recepto

93 Sortilin can impact the intracellular response to brain-

94 A truncated form of sortilin causes BDNF missorting to the constitutive secr

95 ntrast, we demonstrate NSG2 has no effect on sortilin cell surface abundance or progranulin uptake, s

96 ce biotinylation, we found only NSG1 reduced sortilin cell surface expression, which caused significa

97 ng specificity for NSG1 in the regulation of sortilin cell surface expression.

98 Furthermore, sortilin co-localizes with, and enhances accumulation of

99 njury; however, the majority of small p75NTR-sortilin coexpressing neurons are lost 25 days after sci

100 for the p75 neurotrophin receptor (p75(NTR))-sortilin complex.

101 hat sortilin interacts with BACE1 and that a sortilin construct lacking its cytoplasmic domain, which

102 Together, these data show that sortilin contributes to pancreatic cancer invasion and c

103 Collectively, our findings indicate that sortilin controls adipose tissue fatty acid oxidation by

104 e in neurons, and this is dependent upon the sortilin cytoplasmic tail.

105 found that siRNA against TrkA, p75(NTR), and sortilin decreased cell survival and cell migration thro

106 Knockdown of sortilin decreases both formation of GSVs and insulin-re

107 duced atherosclerosis, we found no effect of sortilin deficiency on macrophage recruitment or lipopol

108 Macrophage sortilin deficiency protects against atherosclerosis by

109 etermine the mechanism by which hematopoetic sortilin deficiency reduced atherosclerosis, we found no

110 lve (AV) wire injury (AVWI) mouse model with sortilin deficiency was used to determine the effects of

111 ether this effect was a result of macrophage sortilin deficiency, we transplanted Sort1(-/-);LDLR(-/-

112 espite higher than normal brain APOE levels, sortilin-deficient animals display anomalies in brain li

113 Additionally, transfer of sortilin-deficient BM cells to irradiated atheroscleroti

114 Transfer of sortilin-deficient BM into irradiated atherosclerotic mi

115 In contrast, sortilin-deficient macrophages had significantly reduced

116 Altogether, sortilin defines a pathway required for optimal intracel

117 ficking switch to impair lysosomal-dependant sortilin degradation and to redistribute sortilin to the

118 ontrast, the tagged luminal Vps10p domain of sortilin demonstrates partial co-localization with Glut4

119 Thus sortilin-dependent as well as sortilin-independent sorti

120 mpathetic neuron death that is p75(NTR)- and sortilin-dependent, with hallmark features of apoptosis

121 multiple cytokines including IFN-alpha, and sortilin depletion in plasmacytoid dendritic cells (pDCs

122 Furthermore, mice deficient in APLP2 or sortilin do not exhibit significant changes in liver LDL

123 Thus, although the intracellular domain of sortilin does not contribute to p75(NTR) binding, it doe

124 specific regulation of sortilin and possibly sortilin-driven pathologies.

125 ted the role of the proneurotrophin receptor sortilin during phagosome maturation and mycobacterial k

126 stalk region, to release the ligand binding sortilin ectodomain from the transmembrane and cytoplasm

127 ding and identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch

128 Indeed, expression of the sortilin ectodomain, which corresponds to the domain rel

129 Sortilin ectopically expressed in undifferentiated cells

130 identify an endosomal trafficking component sortilin (encoded by Sort1) in adipose tissues that show

131 lesterol transport and metabolism, including sortilin, endoplasmic reticulum-Golgi intermediate compa

132 Also, primary neurons lacking sortilin exhibit significantly impaired uptake of APOE/A

133 er element that regulates the inclusion of a sortilin exon cassette (termed Ex17b) not normally prese

134 llular uptake and activity of gapmer ASOs in sortilin expressing cells (sixfold) and in spinal cord i

135 strong association between increased hepatic sortilin expression and reduced plasma LDL-C levels in h

136 evidence that genetically increased hepatic sortilin expression both reduces hepatic APOB secretion

137 n through the posttranscriptional control of sortilin expression by TLR signals.

138 Conversely, down-regulation of sortilin expression in HeLa cells leads to an up-regulat

139 e previously reported that increased hepatic sortilin expression in mice reduced plasma LDL-C levels.

140 We also show that sortilin expression is higher in the forebrain than the

141 This study found that sortilin expression was higher in pancreatic cell lines

142 and alterations of intracellular zinc affect sortilin expression.

143 n export, whereas other studies suggest that sortilin facilitates lipoprotein export.

144 SorCS1 and SorL1/SorLA/LR11 belong to the sortilin family of vacuolar protein sorting-10 (Vps10) d

145 As hypothesized, sortilin function impacts the levels of secreted ATZ in

146 Yet, sortilin gene-targeted mice (Sort1(-/-)) and chimeras de

147 In dendritic cells, sortilin had an impact on Ag processing.

148 te atherosclerotic plaque formation) lacking sortilin had reduced secretion of IL-6 and IFN-gamma, bu

149 The overexpression of both proNGF and sortilin has been associated with several neurodegenerat

150 Previous characterization of sortilin has led to the suggestion that it functions to

151 Mice lacking Sortilin have elevations in brain and serum PGRN levels

152 corresponding to vertebrate Trk, p75(NTR) or Sortilin have not been identified in Drosophila, thus it

153 The expression of sortilin in 3T3-L1 cells occurred only upon differentiat

154 Depletion of sortilin in adipocytes results in an increase of mitocho

155 Given the emerging role of sortilin in Alzheimer's disease, these insights may help

156 r study was to elucidate the distribution of sortilin in different immune cell types in mice and huma

157 contrast, little is known about the role of sortilin in immune cells and inflammatory diseases.

158 uences cytokine secretion and that targeting sortilin in immune cells attenuates inflammation and red

159 Studies by several groups support a role for sortilin in inhibiting lipoprotein export, whereas other

160 several groups support an important role for sortilin in lipoprotein metabolism; however, the directi

161 emains controversial, as genetic deletion of sortilin in mice has resulted in variable and conflictin

162 initial studies revealed increased levels of sortilin in post-mortem brain tissue of AD patients and

163 ), neurotrophin receptor p75 (p75(NTR)), and sortilin in the areas showing spongiform changes.

164 lpha secretion, suggesting a pivotal role of sortilin in the exocytic trafficking of IFN-alpha in pDC

165 t ADAM10 is the preferred protease to cleave sortilin in the extracellular stalk region, to release t

166 mice (Sort1(-/-)) and chimeras deficient in sortilin in the immune system were as susceptible as wil

167 Forced expression of sortilin in undifferentiated cells does not recruit IRAP

168 am of VPS35, suggesting a potential role for sortilins in PD.

169 n studies implicate the human Vps10 homolog, sortilin, in cardiovascular disease, and because hepatic

170 novel function for a Vps10p domain protein, sortilin, in controlling BDNF sorting to the regulated s

171 Coexpression of sortilin increased targeting of myc7-Glut4 to the IRVs,

172 f the transporter, whereas overexpression of sortilin increases formation of GSVs and stimulates insu

173 the Golgi protein galactosyltransferase was sortilin independent and occurred even in the absence of

174 Thus sortilin-dependent as well as sortilin-independent sorting mechanisms target aggregate

175 Together, these data demonstrate that sortilin influences cytokine secretion and that targetin

176 Sortilin inhibition also decreased the phosphorylation o

177 Sortilin inhibition by siRNA and the pharmacologic inhib

178 ysosomes is mediated by the sorting receptor sortilin interacting with the lumenal stem domain of GPP

179 Sortilin interacts specifically with BDNF in a region en

180 rLA mainly colocalizes with APP in the soma, sortilin interacts with APP in neurites.

181 We also found that sortilin interacts with BACE1 and that a sortilin constr

182 nd the yeast two-hybrid system, we show that sortilin interacts with Glut4 and IRAP in the vesicular

183 echanistically, the luminal Vps10p domain of sortilin interacts with the first luminal loop of Glut4,

184 aled an important regulatory function of the sortilin intracellular domain in p75(NTR)-regulated intr

185 We determined that sortilin is a high-affinity receptor for the proinflamma

186 Here, we have demonstrated that sortilin is a key regulator of smooth muscle cell (SMC)

187 Sortilin is a lysosomal sorting protein that binds ligan

188 Sortilin is a multiligand sorting receptor responsible f

189 The proneurotrophin receptor sortilin is a protein with dual functions, being involve

190 Sortilin is also expressed in macrophages, but its role

191 Here we demonstrate that sortilin is also involved in retrograde protein traffic.

192 Sortilin is an intracellular chaperone that binds to the

193 Interestingly, the phagosomal association of sortilin is critical for the delivery of acid sphingomye

194 The neuronal membrane protein sortilin is emerging as a regulator of cancer cell devel

195 In the CNS, Sortilin is expressed by neurons and PGRN is most strong

196 Like the related APP receptor SorLA, sortilin is highly expressed in the CNS, but whereas Sor

197 Sortilin is modified by ectodomain shedding, although th

198 Thus, sortilin is not only essential, but also sufficient for

199 e and accessible to proneurotrophin ligands, sortilin is primarily localized to intracellular membran

200 ere, we show that IRAP, similar to Glut4 and sortilin, is retrieved from endosomes to the trans-Golgi

201 In Xenopus embryos, overexpression of sortilin leads to a decrease in phospho-Smad2 levels and

202 ue of AD patients and that overexpression of sortilin leads to increased BACE1-mediated cleavage of A

203 ed expression of Glut4 prior to induction of sortilin leads to rapid degradation of the transporter,

204 The increased sortilin level in pancreatic cancer cells was confirmed

205 We hypothesized that variants in the sortilin-like receptor (SORL1) gene would affect multipl

206 ovel function of the endolysosomal T. gondii sortilin-like receptor (TgSORTLR), which mediates traffi

207 Sortilin localized to calcifying vessels in human and mo

208 In conclusion, sortilin-mediated engagement of LIF signaling in BECs pr

209 hese results propose pro-NGF-induced, p75NTR-sortilin-mediated neuronal death as a critical aspect of

210 Sortilin-mediated PGRN endocytosis is likely to play a c

211 Sortilin-mediated uptake of native LDL into macrophages

212 codes a protein called sortilin, and hepatic sortilin modulates LDL metabolism by targeting apolipopr

213 contrast to mice, the inclusion of Ex17b in sortilin mRNA generates a truncated, nonfunctional, extr

214 Moreover, sortilin mRNA was degraded posttranscriptionally upon st

215 ed the C-rich element (CRE) in the 3' UTR of sortilin mRNA, and depletion of PCBP1 enhanced the degra

216 ed Ex17b) not normally present in the mature sortilin mRNA.

217 gulatory inhibitor, Ex17b is included in the sortilin mRNA.

218 We found that proNGF and p75(NTR), but not sortilin, mRNA and protein were significantly elevated i

219 Our results suggest that sortilin negatively regulates TGF-beta signaling by dive

220 , a kinase-dead TrkA, and siRNA against TrkA sortilin, neurotensin, whereas siRNA against p75(NTR) an

221 Here we show that increased hepatic sortilin not only reduced hepatic apolipoprotein B (APOB

222 iciency was used to determine the effects of sortilin on AV stenosis, fibrosis, and calcification.

223 ntiating 3T3-L1 adipocytes upon induction of sortilin on day 2 of differentiation.

224 however, the directionality of the effect of sortilin on plasma cholesterol and its role in the secre

225 NRH2 critically regulates the expression of sortilin on the neuronal cell surface and promotes p75(N

226 his hypothesis, we have studied targeting of sortilin, one of the major IRV constituents.

227 Secreted PGRN is incorporated into cells via sortilin or cation-independent mannose 6-phosphate recep

228 n demonstrate that mRNA knockdowns of APLP2, sortilin, or both in the human hepatocyte cell lines Hep

229 reduced foam cell formation in vivo, whereas sortilin overexpression in macrophages resulted in incre

230 NT (10 nM) increases the gene expression of sortilin (P < 0.0001) and causes the receptor to be tran

231 Our findings also show increased levels of sortilin (P < 0.0001) in the serum from children with AS

232 mation of a stable ternary complex of proNGF-sortilin-p75NTR.

233 Together, the results of this study identify sortilin phosphorylation as a potential therapeutic targ

234 Here we report that the sorting receptor sortilin plays a key role in cytokine production.

235 e conclude that the proneurotrophin receptor sortilin plays a role in innate, rather than in adaptive

236 TRKB with the intracellular sorting protein sortilin, prevented TRKB degradation, and promoted its a

237 The presence of sortilin promotes alpha-secretase cleavage of APP, unlik

238 Expression of a sortilin protein rescues these defects, downstream of VP

239 Sortilin rapidly endocytoses and delivers PGRN to lysoso

240 ronal cell surface and promotes p75(NTR) and sortilin receptor complex formation, rendering cells res

241 Interestingly, gene expression of the NTR3/sortilin receptor is reduced in the amygdala and dorsola

242 be dependent upon membrane expression of the sortilin receptor, which interacts with p75NTR to promot

243 a the neurotrophin receptor p75(NTR) and the sortilin receptor.

244 ins, combined with prior work on the role of sortilin receptors in mucocyst biogenesis, suggests that

245 tes p75 neurotrophin receptor (p75(NTR)) and sortilin receptors to mediate proapoptotic responses.

246 However, expression of this truncated sortilin redistributes BACE1 from the trans-Golgi networ

247 The use of siRNA to target sortilin reduces (P < 0.001) the NT-stimulated cytokine

248 Sortilin regulated the loading of the calcification prot

249 d as the causative gene within the locus, as sortilin regulates hepatic lipoprotein metabolism.

250 s have reported that genetic variants in the Sortilin-related receptor (SORL1) increased the risk of

251 In humans, genetic variation of sortilin-related receptor, L(DLR class) A repeats contai

252 xplored the role of one of its homologs, the sortilin-related VPS10 domain containing receptor 1 (SOR

253 However, the role of hepatic sortilin remains controversial, as genetic deletion of s

254 along with glucose transporter 4 (Glut4) and sortilin, represents a major component protein of the in

255 In contrast, RNAi suppression of sortilin results in decreased BACE1-mediated cleavage of

256 enhancer element is consistently present in sortilin RNA of mice and other species but absent in pri

257 Mase activity and increased plasma levels of sortilin, S1P, and soluble NOX2-derived peptide (sNOX2-d

258 The current studies show that sortilin selectively co-immunoprecipitates with the clea

259 Loss-of-function studies demonstrated that sortilin serves as a bona fide receptor for LDL in vivo

260 hese findings characterize the regulation of sortilin shedding and identify a novel mechanism by whic

261 We identify sortilin shedding at the cell surface and in an intracel

262 al framework for NSG1-mediated regulation of sortilin shedding.

263 hermore, the inhibition of both p75(NTR) and sortilin signaling attenuated synapse elimination.

264 In addition, sortilin small interfering RNA introduced into primary n

265 x (Vps35, Vps26) and its putative receptors (sortilin, SorL1, SorCS1)] have been implicated in the mo

266 ng 10 (Vps10) family of receptors (including sortilin, SorL1, SorCS1, SorCS2, and SorCS3) play pleiot

267 the vesicular sorting of the retromer cargo, sortilin, SorLA and cation-independent mannose 6-phospha

268 , and unbiased expression cloning identifies Sortilin (Sort1) as a binding site.

269 issue of Neuron, Hu and colleagues identify Sortilin (SORT1) as a key neuronal receptor for PGRN tha

270 The gene encoding sortilin (SORT1) has been implicated as the causative ge

271 Recent discoveries demonstrating sortilin (SORT1) is a neuronal receptor for PGRN endocyt

272 SNP rs646776 is located near sortilin (SORT1), and the minor C allele of rs646776 was

273 potential mechanism linking misregulation of sortilin splicing with altered PGRN metabolism.

274 between the cytoplasmic domains of NRH2 and sortilin that impair lysosomal degradation of sortilin.

275 splicing events were detected (including in sortilin, the receptor for progranulin) following deplet

276 fied two potential binding interfaces on the sortilin TMD and demonstrated that the T770W mutation sh

277 ant sortilin degradation and to redistribute sortilin to the cell surface, rendering p75(NTR)-express

278 In cultured 3T3-L1 adipocytes, sortilin together with retromer rescues Glut4 from degra

279 PCBP1 may therefore control the stability of sortilin transcripts by sensing intracellular zinc level

280 pletion of PCBP1 enhanced the degradation of sortilin transcripts, suggesting that PCBP1 can act as a

281 an act as a trans-acting factor to stabilize sortilin transcripts.

282 ere, we probed for novel binding partners of sortilin using multiple and complementary approaches and

283 red the binding characteristics of proNGF to sortilin using surface plasmon resonance and cell-based

284 proteins requires classical receptors of the sortilin/VPS10 family, which indicates that dual mechani

285 Sortilin was expressed most profoundly in murine and hum

286 Accordingly, sortilin was highly expressed by infiltrated perivascula

287 Sortilin was overexpressed in thyroid cancers compared w

288 er with GLUT4 vesicle isolation, showed that sortilin was primarily located in the low density micros

289 is after binding to p75NTR and a coreceptor, sortilin, we asked whether the precursor of BDNF (proBDN

290 death after binding to co-receptors p75(NTR)/sortilin, we hypothesized that overexpression of proNGF,

291 r p75(NTR), and the proneurotrophin receptor sortilin were analyzed with immunohistochemistry in a co

292 ines that stably express wild-type or mutant sortilin were recently established, we examined whether

293 Amyloid precursor-like protein 2 (APLP2) and sortilin were reported to individually bind the proprote

294 when co-expressed with PCSK9, both APLP2 and sortilin were targeted for lysosomal degradation.

295 ds on the expression of the sorting receptor sortilin, which interacts with the unique amino acid res

296 Another NTSR, sortilin, which is common to neurotensin and neurotrophi

297 AP-1 acted through the multi-ligand receptor sortilin while AP-4 sorted multi-transmembrane proteins.

298 We observed interactions of sortilin with multiple cytokines including IFN-alpha, an

299 Co-expression of sortilin with TGF-beta family members leads to decreased

300 timulated by proNGF and mediated by TrkA and sortilin, with the activation of Akt and Src, for the st

301 atherosclerosis in mice lacking hematopoetic sortilin without an effect on plasma LDL-C levels.