ライフサイエンスコーパス: sorting nexin

1 somes that involves tethering to the ER by a sorting nexin.

2 ting, tubular carriers along with a range of sorting nexins.

3 Sorting nexin 1 (SNX1) and SNX2 are the mammalian homolo

4 Sorting nexin 1 (SNX1) and SNX2, homologues of the yeast

5 Acute renal depletion of sorting nexin 1 (SNX1) in mice results in blunted natriu

6 Sorting nexin 1 (SNX1) is a protein that binds to the ep

7 dopamine D5 receptor (D(5)R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor r

8 Here, we report that Hrs interacts with sorting nexin 1 (SNX1), a recently identified mammalian

9 on of vesicle protein sorting 35 (VPS35) and sorting nexin 1 (SNX1), as well as decreased mannose 6 p

10 we investigated whether PAR1 interacted with sorting nexin 1 (SNX1).

11 rotrophin receptors with retromer-associated sorting nexin 1.

12 Sorting nexins 1 (Snx1) and 2 (Snx2) are homologues of t

13 t the putative mammalian retromer components sorting nexins 1 and 2 (Snx1 and Snx2) result in embryon

14 A protein, sorting nexin-1 (SNX1), was identified in a human cell l

15 significant sequence homology with mammalian sorting nexin-1.

16 n c.212 + 1 G > T in the SNX10 gene encoding sorting nexin 10.

17 microtubule-dependent shuttle that requires sorting nexin 11 (Snx11).

18 RGS-PX1 (also known as sorting nexin 13) is a member of both the regulator of G

19 rt the identification of causal mutations in Sorting Nexin 14 (SNX14) found in seven affected individ

20 -associated splice donor site variant in the sorting nexin 14 gene (SNX14) as a strong causative cand

21 Here, we identified mechanisms by which Sorting Nexin 16 (SNX16) controls neuronal endosomal mat

22 Nwk acts through a physical interaction with sorting nexin 16 (SNX16).

23 g endosomal signaling compartment containing Sorting Nexin 16 and a reduction in late endosomes conta

24 Here we show that sorting nexin 17 (Snx 17) is part of the cellular sortin

25 During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of nu

26 Sorting nexin 17 (SNX17) functions as cargo receptor on

27 Sorting nexin 17 (SNX17) is a member of the family of cy

28 ified a novel intracellular adaptor protein, sorting nexin 17 (SNX17), that binds specifically to the

29 ein potentially involved in TCR transport is sorting nexin 17 (SNX17).

30 ies have demonstrated an interaction between sorting nexin 17 and the L2 capsid proteins from a varie

31 FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycli

32 cycling pathway, in part by association with sorting nexin 17, to ensure that virus DNA bound to L2 i

33 llomavirus (HPV) L2 minor capsid protein and sorting nexins 17 and 27 (SNX17 and SNX27) during virus

34 romer.IMPORTANCE Previous studies identified sorting nexins 17 and 27, as well as the retromer comple

35 somal Commander assembly associates with the sorting nexin-17 (SNX17) cargo adaptor to regulate cell

36 d carboxy-terminal tail of the cargo adaptor sorting nexin-17 (SNX17) directly binds to the Retriever

37 Commander organizes the sorting nexin-17 (SNX17)-dependent recycling of hundreds

38 In this study, we identify sorting nexin 18 as a novel FIP5-interacting protein and

39 X domain of the novel D(1) R-binding partner sorting nexin 19 (SNX19) resulted in D(1) R partitioning

40 luding a class of exon 9-spliced isoforms of Sorting nexin-19 (SNX19(d9)) and an isoform of Arsenic m

41 Sorting Nexin 2 (SNX2), which is involved in trafficking

42 Sorting nexin 27 (SNX27) contains a PDZ domain that is p

43 Here we show that sorting nexin 27 (SNX27) functions as an adaptor that co

44 Mass spectrometry identified sorting nexin 27 (SNX27) in isolated endosomes as a PTHR

45 Sorting nexin 27 (SNX27) is a 62-kDa protein localized t

46 Sorting nexin 27 (SNX27) is a PDZ-containing protein kno

47 Here, we show that sorting nexin 27 (SNX27) is required for efficient PDZ-d

48 s regulated by the psychostimulant-sensitive sorting nexin 27 (SNX27) protein through a class I (-X-S

49 Sorting nexin 27 (SNX27), a brain-enriched PDZ domain pr

50 fies one member of the sorting nexin family, Sorting Nexin 27 (SNX27), as a critical component in thi

51 oteins and the related PX-FERM family member sorting nexin 27 (SNX27), which is mediated in part by a

52 ified a unique rodent intracellular protein, sorting nexin 27 (SNX27), which regulates the traffickin

53 The sorting nexin 27 (SNX27)-retromer complex is a major reg

54 entification of the OTULIN interactor SNX27 (sorting nexin 27), an adaptor of the endosomal retromer

55 th protein kinase C alpha 1, syntenin-1, and sorting nexin 27.

56 The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropatho

57 Here, we describe Sorting Nexin 3 (SNX3), a member of the recycling retrom

58 isoforms of the retromer-associated protein sorting nexin 3 (SNX3), including a novel isoform that b

59 mined interactions between components of the sorting nexin 3 (SNX3)-retromer sorting pathway using qu

60 ed to endosomes by the small GTPase Rab7 and sorting nexin 3.

61 Sorting nexin 4 (SNX4) is an evolutionary conserved orga

62 and have identified essential roles for the sorting nexin 4 (SNX4)-mediated, signal-independent path

63 egulation of vesicular trafficking regulator sorting nexin 5 (SNX5) expression, and PI3 kinase activa

64 screens, we find that the endosomal protein sorting nexin 5 (SNX5)(3,4) is essential for virus-induc

65 e discovery of a dynamic interaction between sorting nexin 5 (SNX5), a component of the mammalian ret

66 In this pathway, PIPKIgammai5 interacts with sorting nexin 5 (SNX5), a protein that binds PtdIns4,5P(

67 d regulation of intracellular traffic (e.g., sorting nexin 5 [SNX5], SNX6, and SNX9).

68 e retromer components identified in mammals, sorting nexin 5 and 1 (SNX5; SNX1) have recently been fo

69 reported that IncE binds specifically to the Sorting Nexin 5 Phox domain (SNX5-PX) and disrupts retro

70 CHC22 binds to sorting nexin 5 through a coiled-coil domain present in

71 inity purification (TAP), we herein identify sorting nexin 6 (SNX6) as a BACE1-associated protein.

72 We demonstrate that GIT1 interacts with sorting nexin 6 (SNX6), a member of the SNX family that

73 ein signaling complex composed of eukaryotic sorting nexin 9 (SNX9) and neuronal Wiskott-Aldrich synd

74 Here, we identify sorting nexin 9 (SNX9) as a new regulator of breast canc

75 Under these conditions, sorting nexin 9 (Snx9) can be implicated as a specific a

76 Sorting nexin 9 (SNX9) functions in a complex with the G

77 chemical, and immunofluorescence approaches, sorting nexin 9 (SNX9) is identified as being required f

78 upon CD28 triggering, the BAR-domain protein sorting nexin 9 (SNX9) is recruited to CD28 clusters at

79 target cell's plasma membrane and recruiting sorting nexin 9 (SNX9), a central multifunctional endocy

80 inflammatory conditions, we discovered that sorting nexin 9 (SNX9), a protein that participates in e

81 hat is fused to an aminoterminal sequence of sorting nexin 9 (SNX9), which was previously shown to bi

82 derived vesicles in a manner that depends on sorting nexin 9 (SNX9).

83 several host proteins, including N-WASP and sorting nexin 9 (SNX9).

84 is, namely the sorting nexin protein SH3PX1 (sorting nexin 9).

85 Sorting nexin 9, an abundant dynamin partner, transientl

86 e temporal ordering of three proteins-actin, sorting nexin 9, and clathrin-in the endocytic pathway.

87 identified protein partner of dynamin, SNX9, sorting nexin 9.

88 g an initial proteomic screen, we identified sorting nexin-9 (SNX9) and dynamins, key components of c

89 knockout validation experiments, we uncover sorting nexin-9 (SNX9) as a mediator of T cell exhaustio

90 ic lysine beta-hydroxybutyrylation (Kbhb) of sorting nexin-9 (SNX9), a key regulator of MDV biogenesi

91 iven by phosphoinositide-3-kinase (PI3K) and sorting-nexin-9 (SNX9).

92 Unlike many sorting nexins, a SNX15 ortholog has not been identified

93 17) is a member of the family of cytoplasmic sorting nexin adaptor proteins that regulate endosomal t

94 an that observed for the knockdown of either sorting nexin alone.

95 These sorting nexins also associated with the long isoform of

96 In mammals, it is composed of a dimer of sorting nexins and of the core retromer consisting of va

97 Sorting nexins are a family of phox homology domain cont

98 Despite their hydrophilic nature, the sorting nexins are found partially associated with cellu

99 of cargo into transport carriers coated with sorting nexin BAR domain proteins (SNX-BARs).

100 nt of the retromer complex and the endosomal sorting nexin-BAR proteins into VROs.

101 e delivery of the co-opted retromer complex, sorting nexin-BAR proteins, and lipid enzymes into VROs

102 esses in collaboration with the retromer and sorting nexins, but its in vivo function has not been ex

103 ains are in many protein families, including sorting nexins, centaurins, and oligophrenins.

104 We find that sorting nexin CG1514 or Snazarus (Snz) associates with p

105 vacuole endosome dependent on the Snx4-Atg20 sorting nexin complex.

106 nt role and begins to shed light on how both sorting nexins contribute to retromer and retriever recr

107 eracting retromer complex, consisting of the sorting nexin dimer (SNX-BAR) and the trimeric cargo sel

108 lishing a precedent for a mechanism by which sorting nexins expand the repertoire of retromer-depende

109 studies have revealed that retromer-related Sorting Nexin family (SNX)-Bin/Amphiphysin/Rvs (BAR) pro

110 ive, this study identifies one member of the sorting nexin family, Sorting Nexin 27 (SNX27), as a cri

111 present the first mutations in the mammalian sorting nexin gene family and indicate that sorting nexi

112 af-6 mutants, we identified an allele of the sorting nexin gene snx-1.

113 sability, due to truncating mutations in the sorting nexin gene SNX14, encoding a ubiquitously expres

114 closure, we investigated the role of Snx3, a sorting nexin gene.

115 an endocytic recycling pathway requiring the sorting nexin Grd19/Snx3p, the pentameric retromer compl

116 As with Golgi proteins, this requires the sorting nexin Grd19p and components of the retromer coat

117 ssible implication for overexpression of the sorting nexin in tumor samples.

118 and differential functions of two groups of sorting nexins in phagosome maturation and reveal a sign

119 ur findings suggest a general role for yeast sorting nexins in protein retrieval, rather than degrada

120 ytosis and SH3PX1 has sequence similarity to sorting nexins in yeast, we propose that endophilin I an

121 rols the retrograde transport of CI-M6PR via sorting nexins, including the PI4P effector SNX6.

122 We also show that both sorting nexins may interact with either of the recycling

123 ed, although the tissue distribution of each sorting nexin mRNA varies.

124 The FERM-like domain-containing sorting nexins of the SNX17/SNX27/SNX31 family have been

125 At the same time, retromer associated sorting nexin one (SNX-1) and its binding partner, J-dom

126 han degradation, and indicate that different sorting nexins operate in different classes of endosomes

127 sorting nexin gene family and indicate that sorting nexins perform essential functions in mammals.

128 y been implicated in endocytosis, namely the sorting nexin protein SH3PX1 (sorting nexin 9).

129 Here, we show that sorting nexin protein Snx14, an ER-resident protein asso

130 PS35/VPS29 subunits) assembles with multiple sorting nexin proteins on membranes to mediate endosomal

131 ain undefined, and retromer engages multiple sorting nexin proteins to sort cargoes to different dest

132 infection but that double knockdown of both sorting nexins results in a striking reduction in infect

133 -dependent recycling tubules marked by actin/sorting nexin/retromer tubular (ASRT) microdomains.

134 The regulation of endosomal trafficking via sorting nexins reveals a previously unknown mechanism fo

135 Sorting nexin (SNX) 1 and SNX2 are mammalian orthologs o

136 hox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged re

137 Vps17 is a sorting nexin (SNX) and a component of the retromer, a p

138 The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and

139 that participates in cargo recognition and a sorting nexin (SNX) dimer that binds to endosomal membra

140 Mammalian retromer is composed of a sorting nexin (SNX) dimer that binds to phosphatidylinos

141 Two other sorting nexin (SNX) family members, namely SNX27 and SNX

142 The sorting nexin (SNX) family of proteins is characterized

143 There are 17 human members of the sorting nexin (SNX) family of proteins that contain Phox

144 e regulator of G protein signaling (RGS) and sorting nexin (SNX) protein families.

145 responses, we identified the members of the SORTING NEXIN (SNX) protein family.

146 Retromer (VPS26/VPS35/VPS29) binds multiple sorting nexin (SNX) proteins on endosomal membranes, but

147 Sorting nexin (SNX) proteins that normally function in e

148 s a Phox (PX) domain that resembles those in sorting nexin (SNX) proteins.

149 are sorted to different pathways, in part by sorting nexin (SNX) proteins.

150 sorting pathway in conjunction with various sorting nexin (SNX) proteins.

151 nsport, the targeting of the retromer-linked sorting nexin (SNX)-Bin, Amphiphysin, and Rvs (BAR) prot

152 5 trimer and a membrane-deforming subunit of sorting nexin (SNX)-Bin, Amphyphysin, and Rvs (BAR; SNX-

153 Sorting nexins (SNX) are a family of proteins containing

154 Sorting nexins (SNX) are a family of PX domain-containin

155 Sorting nexins (SNX) comprise a family of proteins with

156 Sorting nexins (SNX) orchestrate membrane trafficking an

157 mplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6.

158 We identify five (clathrin, dynamin1, AP2, sorting nexins [SNX] SNX27, and SNX1) that increase and

159 When expressed in COS7 cells, epitope-tagged sorting nexins SNX1, SNX1A, SNX2, and SNX4 coimmunopreci

160 ins, named Vps26, Vps29, and Vps35, plus the sorting nexin, SNX1.

161 ve identified a novel 342-amino acid residue sorting nexin, SNX15, and a 252-amino acid splice varian

162 recently discovered pathway, which includes sorting-nexin SNX17, Retriever, WASH, and CCC complexes.

163 Herein we show that the sorting nexin SNX19 tethers endolysosomes to the endopla

164 omologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4).

165 vidence, however, as to whether a homologous sorting nexin, SNX2, is truly a component of the retrome

166 Retromer and its associated sorting nexin, SNX27, phenocopied each other in matrix d

167 rize the interaction between L2 and a second sorting nexin, SNX27, which is also part of the retromer

168 Like most sorting nexins, SNX27 possesses a functional PX domain t

169 We further showed that the cargo-selective sorting nexin Snx3 is required for Neo1 trafficking and

170 We show that the sorting nexin SNX3 is transported with Rab5a vesicles an

171 bled with the non-Bin1/Amphiphysin/Rvs (BAR) sorting nexin SNX3 using cryo-electron tomography.

172 he VPS26 and VPS35 subunits of retromer, the sorting nexin SNX3, and a recycling signal from the diva

173 eins contains a cytosolic tail that binds to sorting nexin Snx3.

174 s identified a requirement for the conserved sorting nexin Snx4 in the autophagic turnover of proteas

175 via two independent pathways mediated by the sorting nexins Snx4/41/42 and the retromer complex, resp

176 ase (Drs2-Cdc50), an F-box protein (Rcy1), a sorting nexin (Snx4-Atg20), and the COPI coat complex.

177 We demonstrate that Snx4 cooperates with sorting nexins Snx41 and Snx42 to mediate proteasome tur

178 Snc1p from post-Golgi endosomes requires the sorting nexin Snx4p, to which Snc1p can be cross-linked.

179 he membrane tubulating BAR domain-containing sorting nexins SNX5 and SNX6.

180 The sorting nexin, SNX9, localizes to clathrin-coated pits w

181 IncE binds to sorting nexins (SNXs) 5/6, components of the retromer, w

182 We screened the Drosophila sorting nexins (SNXs) and discovered that one, SH3PX1, p

183 Sorting nexins (Snxs) are a recently discovered family o

184 Sorting nexins (SNXs) are regulators of endosomal sortin

185 Sorting nexins (SNXs) or phox homology (PX) domain conta

186 ing family of proteins known collectively as sorting nexins, some of which have been shown to be invo

187 The retromer complex, composed of sorting nexin subunits and a Vps26/Vps29/Vps35 trimer, m

188 GTP and requires the Vps5 and Vps17 retromer sorting nexin subunits.

189 demonstration of a large conserved family of sorting nexins that interact with a variety of receptor

190 NX-1, and SNX-6, three BAR domain-containing sorting nexins, that act in two parallel pathways to dri

191 sphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, a

192 SNX27, however, is the only sorting nexin to contain a PDZ domain.

193 The ability of sorting nexins to bind specific phospholipids as well as

194 ed by PtdIns(3)P, and executed through these sorting nexins to degrade apoptotic cells.

195 The yeast sorting nexins Vps5p and Vps17p form a dimer and are als

196 ly define the different domains of the yeast sorting nexins Vps5p and Vps17p, we have generated vario

197 sting findings with yeast orthologs of other sorting nexins, we propose that overexpression of SNX15