ライフサイエンスコーパス: spaceflight

1 d mitigate the physiological consequences of spaceflight.

2 s were examined in mouse ocular tissue after spaceflight.

3 blem identified in the past decade of manned spaceflight.

4 molecular basis for how organisms respond to spaceflight.

5 ward fluid shift and axial body unloading of spaceflight.

6 anges of confluent human fibroblast cells in spaceflight.

7 tation of immune system dysregulation during spaceflight.

8 considered the greatest human health risk of spaceflight.

9 ar system of the astronauts before and after spaceflight.

10 sponse that was induced during the course of spaceflight.

11 ing that tolerance induction was impaired by spaceflight.

12 f sleep-promoting drugs was pervasive during spaceflight.

13 creased nICP to relatively high levels after spaceflight.

14 ormation of this biofilm architecture during spaceflight.

15 t diminished vasoconstrictor responses after spaceflight.

16 ppression of immune function observed during spaceflight.

17 vations in brain blood flow may occur during spaceflight.

18 irment of visual acuity in astronauts during spaceflight.

19 n-microbe interactions may be altered during spaceflight.

20 ted measures ANOVA), but not during or after spaceflight.

21 nd possibly even improved, by short-duration spaceflight.

22 cantly from preflight values during or after spaceflight.

23 were not different before, during and after spaceflight.

24 lenge of upright tilt and were unaffected by spaceflight.

25 2) during tilt after spaceflight than before spaceflight.

26 ciceptors is preserved during short duration spaceflight.

27 sa was monitored in constant darkness during spaceflight.

28 ploring the health consequences of prolonged spaceflight.

29 ic, metabolomic, and epigenetic responses to spaceflight.

30 icate that CMV may further reactivate during spaceflight.

31 seline values, was also found 10 days before spaceflight.

32 bone ECM and osteoblast cell shape occur in spaceflight.

33 45 days before and within 2 h after a 17 day spaceflight.

34 trix accumulation after growth activation in spaceflight.

35 based bed rest can serve as a model of human spaceflight.

36 cal due to lack of technologies suitable for spaceflight.

37 ne function persist to 1-week post-simulated spaceflight.

38 Approximately 6 to 12 months of spaceflight.

39 nges during prolonged periods of bed rest or spaceflight.

40 ested before, during, and up to 1 year after spaceflight.

41 s before and immediately after long-duration spaceflight.

42 o altered sensory environment states such as spaceflight.

43 Dural venous sinus volumes before and after spaceflight.

44 n detect changes in cerebral activity during spaceflight.

45 ted with optic disc edema development during spaceflight.

46 t the adverse cardiovascular consequences of spaceflight.

47 not been comprehensively investigated during spaceflight.

48 to physiological decrements observed during spaceflight.

49 aemoglobin concentration after long-duration spaceflight.

50 ue to hindlimb unloading alone and simulated spaceflight.

51 ld type mice, were largely maintained during spaceflight.

52 ether ICP would increase after long-duration spaceflight.

53 und-based controls before, during, and after spaceflight.

54 transport, and metabolism in the brain after spaceflight.

55 rolled astronauts with planned long-duration spaceflight.

56 hondrial stress as a consistent phenotype of spaceflight.

57 letal deficits observed in astronauts during spaceflight.

58 ucture and BRB integrity following long-term spaceflight.

59 ments in human medicine and long-term manned spaceflight.

60 Diastolic BP was unchanged during and after spaceflight.

61 yer thickness were significantly lower after spaceflight.

62 and emotion regulation during long-duration spaceflight.

63 g activities of daily living before or after spaceflight.

64 f the putative health risks for future human spaceflight.

65 d proteins were changed in the livers during spaceflight.

66 ealth and well-being during future long-term spaceflights.

67 ' immune defense during short- and long-term spaceflights.

68 11 astronauts before and after long-duration spaceflights.

69 ound in urine samples from astronauts before spaceflight (10.6%) than in urine from the healthy contr

70 Haemoglobin decreased significantly after spaceflight (14.6 +/- 0.8 to 13.3 +/- 0.7 g/dL, P < 0.00

71 volumes remained increased at 360 days after spaceflight (28 mL; P < .001).

72 were not different before, during, and after spaceflight (41 +/- 4, 38 +/- 5 and 46 +/- 6 bursts min(

73 light (6.09 h [0.67]), in the 11 days before spaceflight (5.86 h [0.94]), and during the 2-week inter

74 ons obtained significantly less sleep during spaceflight (6.09 h [0.67]), in the 11 days before space

75 eek interval scheduled about 3 months before spaceflight (6.41 h [SD 0.65]) compared with in the firs

76 96 h [0.56] obtained), in the 11 days before spaceflight (7.35 h [0.51], 6.04 h [0.72]), and about 3

77 ], 6.04 h [0.72]), and about 3 months before spaceflight (7.40 h [0.59], 6.29 h [0.67]) compared with

78 upright tilt were smaller after than before spaceflight (absolute, -4 +/- 3 cm s(-1) after versus -1

79 e findings represent the first evidence that spaceflight affects community-level behaviors of bacteri

80 A detailed understanding of how spaceflight affects human health is essential for long-t

81 the known hazards of human spaceflight, how spaceflight affects living systems through these six fun

82 Spaceflight also reduced arterial ryanodine receptor-3 m

83 rpose of this study was to determine whether spaceflight alters gene expression profiles and induces

84 s of head-down tilt bed rest (HDBR), another spaceflight analog.

85 Using the spaceflight analogue 30 days of strict 6 degrees head-do

86 Bed rest is a well-established spaceflight analogue that combines the adaptations assoc

87 headward fluid shifting in microgravity, as spaceflight analogues.

88 caffeine were reduced immediately following spaceflight and 1 d postflight.

89 ted a mean (SD) of 525.8 (187.5) days before spaceflight and 2.0 (1.5) days after return to Earth.

90 of the soleus transcriptome profiles between spaceflight and a publicly available data set for hindli

91 rmance may decrease over extended periods of spaceflight and cause visual impairment.

92 ght missions were obtained on Earth prior to spaceflight and during flight.

93 tional unloading was achieved during orbital spaceflight and following unilateral sciatic neurotomy.

94 alth concern for astronauts during long-term spaceflight and for patients during prolonged bed rest o

95 Here, we examined the systemic effects of spaceflight and fracture surgery/healing on several non-

96 V reactivation occurred in astronauts before spaceflight and indicate that CMV may further reactivate

97 Experimental mice destined for spaceflight and mice that remained on the ground receive

98 ent study was to characterize the effects of spaceflight and reentry to 1 g on the structure and inte

99 One intriguing finding was that both spaceflight and surgery resulted in virtually identical

100 uring the prolonged isolation of exploration spaceflight and the need to ensure maintenance of circad

101 the strict head-down tilt bed rest model of spaceflight and this led to the development of optic dis

102 spinal fluid (CSF) hydrodynamics relative to spaceflight and to establish a comprehensive model of re

103 t from enhanced ophthalmic monitoring during spaceflight and use of countermeasures against spaceflig

104 n culture (FTOC), we examined the effects of spaceflight and vector-averaged gravity on T cell develo

105 dio-acceleration during standing than before spaceflight, and in some, orthostatic hypotension and pr

106 Mean MCAv increased significantly after spaceflight (ANOVA, P = 0.007).

107 sks of a dysregulated immune response during spaceflight are important to understand as plans emerge

108 g the physiological consequences of extended spaceflight are loss of skeletal muscle and bone mass.

109 The neurobehavioral risks associated with spaceflight are not well understood.

110 nt does not contribute to the development of spaceflight associated neuro-ocular syndrome.

111 causal relationship between elevated ICP and spaceflight associated optical changes.

112 The spaceflight-associated neuro-ocular syndrome (SANS) affe

113 provide insight into the pathophysiology of spaceflight-associated neuro-ocular syndrome and elucida

114 ower ICP without impairing CPP to counteract spaceflight-associated neuro-ocular syndrome in astronau

115 s of optic disc edema, a hallmark finding of spaceflight-associated neuro-ocular syndrome.

116 eightlessness have the potential to mitigate spaceflight-associated neuro-ocular syndrome.

117 aceflight and use of countermeasures against spaceflight-associated neuro-ocular syndrome.

118 velocity increased independently of nICP and spaceflight-associated ocular alterations.

119 During spaceflight, astronauts face a unique set of stressors,

120 Recovery from 6-month spaceflight at the International Space Station: muscle-r

121 ional crew members before, during, and after spaceflight at the NASA Johnson Space Center and Interna

122 As spaceflight becomes more common with commercial crews, b

123 anding the long-term cardiac consequences of spaceflight beyond low-Earth orbit with the added stimul

124 odel organisms have revealed six features of spaceflight biology that guide our current understanding

125 mics, as well as the identification of novel spaceflight biomarkers and the development of correspond

126 remained the same before, during, and after spaceflight (both P>0.05).

127 otential was observed in measurements of the spaceflight bulk agar.

128 nic cultures of microbes have indicated that spaceflight can lead to increases in growth and virulenc

129 assessment of brain tissue demonstrated that spaceflight caused an up to 2.2-fold increase in apoptos

130 We tested the hypothesis that spaceflight causes changes in microRNA (miRNA) expressio

131 loss in mice following exposure to simulated spaceflight, combining microgravity (by hindlimb unloadi

132 rmine whether the roots of plants exposed to spaceflight conditions may be experiencing hypoxia.

133 hematological outcomes 1-week post-simulated spaceflight conditions, suggesting recovery from spacefl

134 (cfRNA) collected before, during, and after spaceflight confirms previously reported mitochondrial d

135 tigation as it may support use as a holistic spaceflight countermeasure.

136 ation (SAHC) has been proposed as a holistic spaceflight countermeasure.

137 increased vulnerability to infection during spaceflights dating back to Apollo and Skylab.

138 n has been demonstrated in astronauts during spaceflights dating back to Apollo and Skylab; this coul

139 In conclusion, 17 days of spaceflight decreased force and increased shortening vel

140 Mice exposed to 37d of spaceflight displayed elevated liver mass (33%) and sele

141 is study, we tested the null hypothesis that spaceflight does not impair human baroreflex mechanisms.

142 gesting that the cephalad fluid shift during spaceflight does not systematically or consistently elev

143 e sacrificed on-orbit and exposed to varying spaceflight durations (i.e. 21, 37, and 42 days vs 13 da

144 hese results may have implications for human spaceflight, e.g., a Mars mission, and clinical medicine

145 ave illuminated fundamental issues regarding spaceflight effects on plant growth and development.

146 ionizing radiation is an innate risk of the spaceflight environment that can cause DNA damage and al

147 ey immune processes that are affected by the spaceflight environment.

148 In the history of manned spaceflight, environmental monitoring has relied heavily

149 Moreover, the biofilms formed during spaceflight exhibited a column-and-canopy structure that

150 Astronauts returning from long-duration spaceflight experience ocular remodeling related to ceph

151 To curate and organize expensive spaceflight experiments conducted aboard space stations

152 Spaceflight experiments over the past few decades have r

153 Spaceflight exposure appears to effect a hypoxic respons

154 ADH activity increased by 89% as a result of spaceflight exposure for both CHROMEX-03 and -05 experim

155 ere grown in agar medium during 6 or 11 d of spaceflight exposure on shuttle missions STS-54 (CHROMEX

156 The authors report that prenatal spaceflight exposure shapes vestibular-mediated behavior

157 occurs in various genetic backgrounds during spaceflight exposures of weeks to months.

158 (N = 9) were also tested to control for non-spaceflight factors such as lack of practice between pre

159 + Surgery); (3) Sham surgery mice housed in spaceflight (Flight + Sham); and (4) Femoral segmental b

160 segmental bone defect surgery mice housed in spaceflight (Flight + Surgery).

161 suggest that after a total period of 43 h of spaceflight FN transcription, translation, or altered ma

162 Measures were conducted before spaceflight followed by 1, 30, 90, 180, and 360 days aft

163 gradation kinetics of thiamine in three NASA spaceflight foods (brown rice, split pea soup, BBQ beef

164 tamins such as thiamine (vitamin B1) in NASA spaceflight foods intended for extended-duration mission

165 Exposure to spaceflight for 16 days resulted in a loss of precursors

166 It serves as a spaceflight ground analog, reflecting some conditions of

167 ular distensibility greater in arteries from spaceflight group (SF) mice (n=7) relative to ground-bas

168 oring of muscle health for the first time in spaceflight (> 180 days).

169 examined medication use during long-duration spaceflights (>30 d).

170 Crewmembers with higher CRF before spaceflight had a 29% reduced risk of latent viral react

171 Prolonged exposure to spaceflight had little impact on systolic BP variability

172 Extended spaceflight has been shown to adversely affect astronaut

173 Spaceflight has several detrimental effects on the physi

174 Although ground-based analogues for human spaceflight have provided insights into these stressors

175 yte activation with mitogenic lectins during spaceflight have shown a dramatic inhibition of activati

176 on orbit could permit an advent of precision spaceflight healthcare.

177 Here we review the known hazards of human spaceflight, how spaceflight affects living systems thro

178 into space, it is crucial to understand how spaceflight impacts the immune system.

179 In this study, we tested the hypothesis that spaceflight impairs cerebral autoregulation.

180 Spaceflight imposes numerous adaptive challenges for ter

181 ng positions before and after 4-12 months of spaceflight in 11 astronauts (10 males and 1 female, 46

182 ng positions before and after 4-12 months of spaceflight in 11 astronauts (10 males and 1 female, 46

183 eriods before, during, and after 6 months of spaceflight in 12 astronauts (4 women; age 48+/-5 [mean+

184 The nICP did not change significantly after spaceflight in the 11 astronauts.

185 s, nICP did not increase after long-duration spaceflight in the vast majority (>90%) of astronauts, s

186 signaling is impaired in spaceflight or that spaceflight inappropriately induces Adh/GUS activity for

187 As human spaceflight increases in duration, cultivation of crops

188 These findings demonstrate spaceflight induced atrophy is unique, and that understa

189 uid shift reversal may be needed to mitigate spaceflight-induced changes and/or other factors are inv

190 At the pathway level, some spaceflight-induced changes in the brain exhibit similar

191 re subjected to 60-day HDBR at 6 to simulate spaceflight-induced fluid shifts.

192 The health risks associated with spaceflight-induced ocular structural and functional dam

193 The spaceflight-induced optic nerve lengthening and anterior

194 Spaceflight-induced potential adverse neurovascular dama

195 Collectively, spaceflight-induced reductions in myogenic vasoconstrict

196 The neural correlates of spaceflight-induced sensorimotor impairments are unknown

197 een MTRR 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes.

198 Long-duration spaceflight induces detrimental changes in human physiol

199 to address specifically the possibility that spaceflight induces the plant hypoxia response and to as

200 ndbreaking flight will be the longest rodent spaceflight investigation and the first to explore the e

201 point to a strong stress response induced by spaceflight involving muscle tissue and the proinflammat

202 Spaceflight is a unique environment that includes at lea

203 eflight conditions, suggesting recovery from spaceflight is an unremitting process.

204 creases in duration, cultivation of crops in spaceflight is crucial to protecting human health under

205 ure to elevated intracranial pressure during spaceflight is hypothesized to be a contributing factor,

206 the extent of bone recovery after prolonged spaceflight is important for understanding risks to astr

207 Spaceflight is known to diminish bone mass and reduce im

208 Spaceflight is known to impose changes on human physiolo

209 Spaceflight is known to induce severe systemic bone loss

210 educed growth response in lymphocytes during spaceflight is linked to apoptosis.

211 We conclude that sleep quality during spaceflight is not degraded by sleep-disordered breathin

212 Commercial spaceflight is now becoming accessible to members of the

213 how that immune tolerance may be impaired in spaceflight, leading to excessive inflammatory responses

214 sympathetic nervous system occurring during spaceflight may be responsible for these postflight alte

215 These data indicate that long-term spaceflight may have pathological and functional consequ

216 ults of mean MCAv suggest that long-duration spaceflight may increase cerebral blood flow, possibly d

217 Organized group circling behavior unique to spaceflight may represent stereotyped motor behavior, re

218 During spaceflight, mean (SE) peripapillary total retinal thick

219 mined protein changes in dissected brains of spaceflight mice, which showed increases in PECAM-1, a m

220 ring the first 24 h of activation using both spaceflight microgravity culture and a ground-based mode

221 vous system and neuromuscular function after spaceflight might contribute to this problem.

222 It seems likely that alterations in spaceflight mission operations (schedule-shifting and li

223 n 2 crew members who completed a 1-year-long spaceflight mission.

224 is technology for future implementation on a spaceflight mission.

225 As future spaceflight missions are planned to increase in duration

226 er observation of astronaut ocular health on spaceflight missions longer than 6 months in duration ma

227 Background Astronauts on long-duration spaceflight missions may develop changes in ocular struc

228 Medication use during spaceflight missions was similar to that noted on the Sp

229 ula of crew members completing long-duration spaceflight missions were obtained on Earth prior to spa

230 observe these molecular biosignatures during spaceflight missions, it is necessary to perform separat

231 sleep aids was about 10 times higher during spaceflight missions.

232 uts on both short-duration and long-duration spaceflight missions.

233 A mean (SD) 184.3 (66.0) days of ISS spaceflight missions.

234 tent viral reactivation during long duration spaceflight missions.

235 ombination may compromise future, long-term, spaceflight missions.

236 We conclude that after 16 days of spaceflight, muscle sympathetic nerve responses to uprig

237 Any mission involving prolonged human spaceflight must be carefully planned to minimize vulner

238 ne (n = 6), 2) ground control (n = 12) or 3) spaceflight (n = 12).

239 that the impaired vasoconstriction following spaceflight occurs through the ryanodine receptor-mediat

240 ases in growth and virulence, the effects of spaceflight on biofilm development and physiology remain

241 s study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture

242 In summary, the effect of spaceflight on bone microarchitecture in ovariectomized

243 , investigating the effects of long-duration spaceflight on CBT at rest and during exercise are clear

244 Understanding the effects of spaceflight on microbial communities is crucial for the

245 ilized to assess the impact of long-duration spaceflight on operator proficiency in a group of 8 astr

246 We evaluated the impact of prolonged spaceflight on orthostatic tolerance and BP profiles in

247 ent study was to characterize the effects of spaceflight on oxidative damage in the mouse brain and i

248 p quality in space, we studied the effect of spaceflight on sleep-disordered breathing.

249 ght experiments and to assess the effects of spaceflight on the growth and function of a model muscul

250 The effects of spaceflight on the infectious disease process have only

251 Effects of spaceflight on the muscles of the murine shoulder.

252 ngs (PSGs) from five healthy subjects before spaceflight, on four occasions per subject during either

253 nderstand the health impact of long-duration spaceflight, one identical twin astronaut was monitored

254 Upon return from spaceflight or resumption of normal posture after bed re

255 al hypoxia response signaling is impaired in spaceflight or that spaceflight inappropriately induces

256 g lower body suction were significant before spaceflight (P < 0.05, repeated measures ANOVA), but not

257 fore spaceflight versus 106+/-9 mm Hg during spaceflight; P<0.01), but it returned to normal upon lan

258 t apex, no apex staining was observed in the spaceflight plants.

259 for better understanding human responses to spaceflight, providing the opportunity to assess how phy

260 trix is a factor in causing these changes in spaceflight, quiescent osteoblasts were launched into mi

261 ditionally, chronic cortisol exposure during spaceflight raises further concerns, although its specif

262 he cephalad fluid shift during long-duration spaceflight rarely increased postflight intracranial pre

263 This is the first report that spaceflight regulates miRNA expression.

264 hile democratizing access to vast amounts of spaceflight related omics data generated from several mo

265 Many spaceflight-related medication uses (at least 10%) were

266 individually, their combined effects during spaceflight remain less understood.

267 robust history of domestic and international spaceflight research, understanding behavioral adaptatio

268 l. that used transcriptomics to evaluate the spaceflight response of the root-tip of the model plant

269 t hypoxia response and to assess whether any spaceflight response was similar to control terrestrial

270 Spaceflight resulted in lower cortical bone accrual in t

271 Spaceflight results in reduced mechanical loading of the

272 ferentially expressed genes (DEGs) in murine spaceflight retinas, which were enriched for genes relat

273 increase in ADH activity associated with the spaceflight roots was realized by a 28% decrease in oxyg

274 auts may exhibit holdover effects from prior spaceflight(s).

275 the SpaceX Inspiration4 crew, we generated "spaceflight secretome profiles," which showed significan

276 es are largely unknown, particularly for the spaceflight (SF) microgravity environment.

277 Two of 4 astronauts studied during spaceflight shed CMV in urine.

278 During long-duration spaceflights, some astronauts develop structural ocular

279 tudy was to test the hypothesis that 13 d of spaceflight [Space Transportation System (STS)-135 shutt

280 Return: R + 1, R + 45, R + 82, R + 194 days) spaceflight, spanning a total of 289 days across 2021-20

281 Longitudinal assessments identified spaceflight-specific changes, including decreased body m

282 Where spaceflight-specific data/equations were not available,

283 Understanding how spaceflight, surgery, and their combination impact non-i

284 the anoxic basin make it optimal for testing spaceflight technology and life detection methods for fu

285 beats min(-1), P = 0.002) during tilt after spaceflight than before spaceflight.

286 the most common fold type to develop during spaceflight; this differs from reports in idiopathic int

287 Prolonged human spaceflight to another planet or an asteroid will introd

288 as estimated non-invasively before and after spaceflight to test whether ICP would increase after lon

289 central nervous system (CNS) changes during spaceflights to ensure optimal performance and protect a

290 Spaceflight triggers long-term neuroplastic changes refl

291 when astronauts return to Earth: after brief spaceflight, up to two-thirds are unable to remain stand

292 BP decreased in space (120+/-10 mm Hg before spaceflight versus 106+/-9 mm Hg during spaceflight; P<0

293 Conclusion Long-duration spaceflight was associated with increased pituitary defo

294 Spaceflight was observed to increase the number of viabl

295 and STS-135, and the biofilms formed during spaceflight were characterized.

296 e formation of the novel architecture during spaceflight were observed to be independent of carbon so

297 soleus fibre diameter and function following spaceflight were similar to those observed after 17 days

298 FC strength also increased during spaceflight when compared to pre-flight (EO: p < 0.05) a

299 anges in microbial virulence associated with spaceflight which may impact the probability of in-fligh

300 The success of interplanetary human spaceflight will depend on many factors, including the b