ライフサイエンスコーパス: spate

1 tly been shown to harbor class 1 and class 2 SPATEs.

2 inker region, upstream of the beta-domain of SPATEs.

3 o the structure-function relationship of the SPATEs and the functional roles of their conserved resid

4 autotransporters of the Enterobacteriaceae (SPATEs) and the pertactin family of Bordetella pertussis

5 We have confirmed that SPATEs are expressed and secreted in poorly oxygenated e

6 SPATEs are subdivided into class 1 and class 2 based on

7 ease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteri

8 ease autotransporters of Enterobacteriaceae (SPATEs) are secreted by Shigella, Salmonella, and Escher

9 sesses the three domains that are typical of SPATE autotransporters: an unusually long signal sequenc

10 he role of conserved residues located in the SPATE beta-barrel-forming region in passenger domain sec

11 h the proteolytic and adhesive activities of SPATE by maintaining the proper protein structure via in

12 on and cleavage of the passenger domain of a SPATE called Tsh, we show here that the mutation of the

13 ansporters of the family Enterobacteriaceae (SPATE) comprise a family of virulence proteins secreted

14 ease Autotransporters of Enterobacteriaceae (SPATEs) contribute to Shigella dissemination within the

15 t elicited cytopathic effects; the remaining SPATEs did not cause any morphological changes to HEp-2

16 the mutation of the same residues in another SPATE (EspP) affects only passenger domain cleavage.

17 onserved aromatic amino acid residues in the SPATE family resulted in approximately 80% reduction of

18 rine protease subfamily of autotransporters (SPATEs) for conserved features indicative of a common se

19 der to demonstrate their significance to the SPATE functions.

20 omologies observed among these proteins, the SPATEs have different pathogenetic functions only partly

21 etter understand the contribution of class 1 SPATEs in enteric infection, we constructed a class 1 SP

22 st a previously unsuspected role for class 1 SPATEs in enteric infection.

23 However, to date the in vivo role of class 1 SPATEs in enteric pathogenesis is unknown.

24 Class 1 SPATEs induce cytopathic effects in numerous epithelial

25 otease ATs of the family Enterobacteriaceae (SPATEs) is characterized by the presence of a conserved

26 enteric infection, we constructed a class 1 SPATE null mutant (Deltacrc1) in C. rodentium.

27 Recently, there has been a spate of articles detailing the many and multifaceted al

28 The recent spate of discoveries of novel acyl-CoA mutases has engen

29 Recently the Southwest has experienced a spate of dryness, which presents a challenge to the sust

30 n light of the growing use of ESIs, a recent spate of highly publicized infectious complications, and

31 There has been a spate of interest in association networks in biological

32 of implanted orbital expanders-is the recent spate of long-term complications reported from previous

33 ent-day African populations, combined with a spate of new archaeological discoveries in Africa.

34 A recent spate of publications has provided evidence for developm

35 The past year has seen a spate of research in the use of HLA transgenic mice in t

36 This popular paradigm has resulted in a spate of research that assumes a fitness cost to resista

37 shown to be effective until recently, when a spate of successes established the broad potential of th

38 ggest that certain conserved residues in the SPATE passenger domain are important for both the proteo

39 A SPATE polypeptide contains a C-terminal translocator dom

40 We further demonstrated that SPATEs promoted Shigella survival in plasma, by cleaving

41 rones in the biogenesis of EspP, a prototype SPATE protein produced by Escherichia coli O157:H7.

42 Here, we show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropatho

43 ligopeptides was found to be unique for each SPATE protein.

44 ecules have collectively been referred to as SPATE proteins (serine protease autotransporter of the E

45 We previously classified SPATE proteins into two classes: cytotoxic (class 1) and

46 Phylogenetic analysis shows the SPATE proteins to represent a distinct subfamily of auto

47 e passenger domain conserved residues in the SPATE proteolytic and adhesive functions using the tempe

48 We suggest that the class-2 SPATEs represent unique immune-modulating bacterial viru

49 autotransporters of the Enterobacteriaceae (SPATEs) represent a group of large-sized, multi-domain e

50 ease autotransporters of Enterobacteriaceae (SPATEs) represent a large family of virulence factors.

51 a, a more refined model for the mechanism of SPATE secretion is presented.

52 hogenic Escherichia coli, is a member of the SPATE (serine protease autotransporters of Enterobacteri

53 uence showed highest similarity to two known SPATE (serine protease autotransporters of Enterobacteri

54 proteins, particularly a subgroup termed the SPATEs (serine protease autotransporters of the Enteroba

55 The SPATEs showed proteolytic activity for several substrate

56 ease autotransporters of Enterobacteriaceae (SPATEs) which also includes Pic from EAEC and Shigella f