ライフサイエンスコーパス: spatial learning

1 pairment in long-term potentiation (LTP) and spatial learning.

2 P.PS mice, and this correlated with improved spatial learning.

3 smission were associated with impairments in spatial learning.

4 ntral striatal circuitry during reward-based spatial learning.

5 ds but not to expected rewards earned during spatial learning.

6 social interaction, repetitive behavior, and spatial learning.

7 between these two brain regions on tests of spatial learning.

8 on and hippocampal-dependent associative and spatial learning.

9 vice versa impaired performance on tests of spatial learning.

10 tuations that utilize habit-like associative spatial learning.

11 tioned taste aversion, fear conditioning and spatial learning.

12 show that CPT1C deficiency strongly impairs spatial learning.

13 aturation of dendritic spines and for proper spatial learning.

14 tinal axon guidance, synaptic functions, and spatial learning.

15 f unlearned fear, sensorimotor function, and spatial learning.

16 mmediate memory, classical conditioning, and spatial learning.

17 ation on neuronal excitability in the EC and spatial learning.

18 ny obvious changes in social behaviors or in spatial learning.

19 ippocampus play an active role in supporting spatial learning.

20 bute to social behavior by supporting social-spatial learning.

21 yperactivity, reduced anxiety, and deficient spatial learning.

22 ocampal inputs have not been measured during spatial learning.

23 ficits in fear-conditioned learning, but not spatial learning.

24 nctional assessment of the brain systems for spatial learning, a form of episodic memory.

25 Long-term consolidation of spatial learning, a function of temporoammonic-CA1 synap

26 ess highly developed perceptual, memory, and spatial learning abilities and are also capable of intri

27 ions of testosterone and corticosterone, but spatial learning abilities and exploratory behaviors wer

28 greater reliance on cached food have better spatial learning abilities and larger hippocampi contain

29 We designed a T-maze to study the spatial learning abilities of crayfish (Orconectes rusti

30 sks are well-validated paradigms for testing spatial learning abilities, manual categorization of per

31 reduced long-term potentiation and impaired spatial learning ability in adults.

32 C consistent with the hypothesis that during spatial learning an experience-dependent memory trace is

33 lpha-OH-THP reversed the deficits in LTP and spatial learning, an effect prevented by the inactive me

34 ropsychological measures of verbal and visuo-spatial learning and an event-related verbal and visual

35 nput-specific role of the alpha5-GABA(A)R in spatial learning and anxiety-related behavior was studie

36 ioral abnormalities, including problems with spatial learning and attention.

37 impaired executive function, attention, and spatial learning and could be due to perturbed mesolimbi

38 2, show hippocampal-dependent impairments in spatial learning and deficits in hippocampal long-term p

39 Spatial learning and exploration, however, is preserved

40 e influence of medial PFC (mPFC) activity on spatial learning and hippocampal coding in a plus maze t

41 l cortex (mEC) enhances the consolidation of spatial learning and impairs the consolidation of cued-r

42 GS14-KO mice exhibited marked enhancement in spatial learning and in object recognition memory compar

43 r performance on two spatial cognitive tasks-spatial learning and memory and a consecutive reversal l

44 inal countered losartan's capacity to rescue spatial learning and memory and blocked losartan's benef

45 -dependent behaviors in adulthood, including spatial learning and memory and fear conditioning.

46 eurons in the dentate gyrus are critical for spatial learning and memory and other hippocampal functi

47 These results suggest that spatial learning and memory are energized by the release

48 at mice lacking CD3zeta exhibited defects in spatial learning and memory as examined by the Barnes ma

49 s rescued in part age-related impairments in spatial learning and memory as well as associative fear

50 nalysis, we found a significant reduction in spatial learning and memory at 24 days post-rmTBI compar

51 ss that confers long-lasting preservation of spatial learning and memory before and after the cerebra

52 ppocampus efficiently reverses Abeta-induced spatial learning and memory deficits by restoring a spec

53 neural stem cell transplantation rescues the spatial learning and memory deficits in aged 3xTg-AD mic

54 We find spatial learning and memory deficits in FE65-KO and FE65

55 eta-CD administration significantly improved spatial learning and memory deficits in Tg19959 mice, di

56 erm potentiation (LTP) and aged mice display spatial learning and memory deficits that are absent fro

57 edicated food containing Pip18 for 4 months, spatial learning and memory deficits were not rescued, p

58 d soluble brain Abeta, leading to aggravated spatial learning and memory deficits, thus emphasizing t

59 including hyperactivity, disinhibition, and spatial learning and memory deficits.

60 ed depressive- and anxiety-like behavior and spatial learning and memory dysfunction.

61 n of the Morris water maze (a common test of spatial learning and memory for rodents) that is designe

62 ons, and higher cognitive functions, such as spatial learning and memory formation.

63 deposition and neuroinflammation and rescued spatial learning and memory function in APPPS1 mice.

64 KO mice also showed enhanced recognition and spatial learning and memory functions.

65 Whereas DG's function in spatial learning and memory has been extensively investi

66 2 deficiency prevented hippocampus-dependent spatial learning and memory impairments induced by crani

67 ession, and impaired synaptic plasticity and spatial learning and memory in 3-mo-old mice.

68 els of BDNF and NT-3 in the CNS and improved spatial learning and memory in a mouse model of AD.

69 e cells, and caused selective alterations in spatial learning and memory in adult mice.

70 as a contributing factor underlying impaired spatial learning and memory in children and adults with

71 e are associated with pronounced deficits in spatial learning and memory in context-dependent fear co

72 impaired synaptic plasticity/maturation and spatial learning and memory in FXS mice, we investigated

73 The CCR5 knockout (KO) also rescues spatial learning and memory in gp120-transgenic mice.

74 AR) subunits in the hippocampus and enhanced spatial learning and memory in hAPP mice.

75 mal short-term synaptic plasticity, LTP, and spatial learning and memory in mice.

76 the most frequently used behavioral assay of spatial learning and memory in rodents - translates to h

77 the most commonly used techniques to assess spatial learning and memory in rodents.

78 oral testing demonstrated a modest effect on spatial learning and memory in SAM-exposed rats.

79 both working memory in prefrontal cortex and spatial learning and memory in the hippocampus.

80 ranulin-deficient mice demonstrated impaired spatial learning and memory in the Morris water maze.

81 hippocampal CA1 LTP, differentially disrupts spatial learning and memory performance in Morris water

82 d the short- and long-term effects of WBI on spatial learning and memory retention and determined whe

83 Also, the treatment ameliorated deficits in spatial learning and memory retention observed in irradi

84 creases in BDNF are associated with improved spatial learning and memory retention.

85 that the diabetic rats with an impairment of spatial learning and memory showed the occurrence of RTN

86 ocampus, as well as in hippocampal-dependent spatial learning and memory tasks, and on the production

87 Further evaluation included other non-spatial learning and memory tasks.

88 een with novel object recognition as well as spatial learning and memory tests.

89 ave severe deficits in hippocampus-dependent spatial learning and memory that are accompanied by enha

90 improves performance on behavioral tasks of spatial learning and memory that are impaired by isoflur

91 NL1 knock-out (KO) mice display deficits in spatial learning and memory that correlate with impaired

92 The beneficial effect of naltrexone on spatial learning and memory under normal conditions appe

93 Spatial learning and memory were assessed using Morris w

94 Spatial learning and memory were assessed using the part

95 cognition, deficits in hippocampal-dependent spatial learning and memory were exaggerated in E4 mice.

96 cocorticoid negative feedback inhibition and spatial learning and memory were impaired.

97 Spatial learning and memory were measured using the Morr

98 Hippo-DKO mice also display abnormal spatial learning and memory whereas CeA-DKO mice have im

99 us, insulin/IGF-1 signaling is important for spatial learning and memory whereas insulin/IGF-1 signal

100 nt roles in regulating both cognitive (e.g., spatial learning and memory) and mood behaviors.

101 APP(E693Q) mice were tested for spatial learning and memory, and only 12-month-old APP(E

102 ment prevented anesthesia-induced deficit in spatial learning and memory, as measured by Morris water

103 ver, LPC-DHA treatment markedly improved the spatial learning and memory, as measured by Morris water

104 lly, we found an exacerbation of deficits in spatial learning and memory, as well as in working and a

105 ar chow throughout their life and tested for spatial learning and memory, brain amyloidosis, tau path

106 open-field exploratory activity yet impaired spatial learning and memory, endophenotypes similar to t

107 at 3, 6, 9, and 12 months of age to evaluate spatial learning and memory, followed by histologic asse

108 c modulator (NAM), rescued their deficits in spatial learning and memory, hippocampal synaptic plasti

109 genetic ablation of LSD1n led to deficits in spatial learning and memory, revealing the functional im

110 extinction and reversal of Morris water maze spatial learning and memory, suggesting that adult neuro

111 ice were associated with extreme deficits in spatial learning and memory, suggesting that TRIM9-direc

112 rea CA1 of hippocampus, a region involved in spatial learning and memory, tau pathology is associated

113 Awake and sleep SWRs both contribute to spatial learning and memory, thought to be mediated by t

114 valuate the importance of the hippocampus in spatial learning and memory, we tested amnesic participa

115 ects were associated with severe deficits in spatial learning and memory.

116 es their dendrite morphogenesis, and impairs spatial learning and memory.

117 ce rescues contextual fear memory as well as spatial learning and memory.

118 in LTP that were associated with deficits in spatial learning and memory.

119 nts in both contextual fear conditioning and spatial learning and memory.

120 increased stereotypic behavior, and impaired spatial learning and memory.

121 ippocampus, as well as hippocampus-dependent spatial learning and memory.

122 a CA1, and deficits in hippocampus-dependent spatial learning and memory.

123 The hippocampus is critical for spatial learning and memory.

124 eparation, a form of dentate gyrus-dependent spatial learning and memory.

125 ie the effect of HCN1 deletion to facilitate spatial learning and memory.

126 nd impaired contextual fear conditioning and spatial learning and memory.

127 riments support a role for DGCs in enhancing spatial learning and memory.

128 nduced brain damage and striking deficits in spatial learning and memory.

129 intact PrP(C) expression exhibit deficits in spatial learning and memory.

130 transgenes, show no detectable impairment of spatial learning and memory.

131 e, suggesting that Smad4 is not required for spatial learning and memory.

132 trimers and Abeta*56 or improve deficits in spatial learning and memory.

133 s were accompanied by significantly enhanced spatial learning and memory.

134 triking behavioral deficits, particularly in spatial learning and memory.

135 se timing of GABAergic interneurons, impairs spatial learning and memory.

136 maze (MWM) is widely used to evaluate rodent spatial learning and memory.

137 ed to decreased Abeta pathology and improved spatial learning and memory.

138 oxidative stress that also exhibit impaired spatial learning and memory.

139 ensive understanding of variability in human spatial learning and navigation.

140 r results validate our topological model for spatial learning and open new avenues for connecting dat

141 in the adult hippocampus play a key role in spatial learning and pattern separation.

142 ival after acute infection) display impaired spatial learning and persistence of phagocytic microglia

143 ippocampus in particular contributes to both spatial learning and recognition memory, but the extent

144 ning task; (2) cognitive performance in both spatial learning and reversal learning tasks was not sig

145 MSCs or scaffolds seeded with hMSCs improved spatial learning and sensorimotor function, enhanced ang

146 verity scores were performed to evaluate the spatial learning and sensorimotor functions, respectivel

147 us is critical for a range of functions from spatial learning and synaptic plasticity to the deficits

148 nactivated CA1 VIP input could still improve spatial learning and was not associated with anxiety.

149 f the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model.

150 overexpressing VPS35 had an amelioration of spatial learning and working memory, which associated wi

151 be (MTL), a brain region that is crucial for spatial learning (and episodic memory) with concomitant

152 ablish a novel intervention that can improve spatial learning, and (3) provide evidence that individu

153 vioral responses that engage motor activity, spatial learning, and emotional processing.

154 anatomical substrates for spatial versus non-spatial learning, and establish Drosophila as a powerful

155 rp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often rep

156 poE3, reduced arteriole blood flow, impaired spatial learning, and increased anxiety-like phenotypes.

157 he cholinergic and AT(4) receptor systems in spatial learning, and indicate for the first time a func

158 naptic transmission, long-term potentiation, spatial learning, and memory in TG mice.

159 included impairments of synaptic plasticity, spatial learning, and memory.

160 llele exhibit deficits in neurotransmission, spatial learning, and memory.

161 in deficits in complex route-based learning, spatial learning, and reference memory.

162 al tests, without affecting performance in a spatial learning- and memory-dependent task.

163 ors modulated by the lateral septum, such as spatial learning, anxiety, and reward-seeking.

164 nal DA levels and signaling as well as mouse spatial learning are controlled in an Nf1 gene dose-depe

165 lies GABA(B) receptor-mediated inhibition of spatial learning as assessed by Morris water maze.

166 anied with deficits in hippocampus-dependent spatial learning as determined by the Morris water maze

167 We have taken spatial learning as our starting point, computationally

168 oral assessments (contextual fear memory and spatial learning), as well as gene and protein analysis

169 al involvement of this white-matter tract in spatial learning, as implied by animal studies.

170 s are required for successful acquisition of spatial learning, as well as reversal learning, but are

171 a5-GABA(A)R in control mice in vivo improved spatial learning but also induced anxiety-like behavior.

172 Behaviorally, CRS significantly impeded spatial learning but enhanced non-spatial cue learning o

173 during an EE experience resulted in enhanced spatial learning but suppressed learning flexibility.

174 turation in hippocampal neurons and impaired spatial learning, but the role of CPT1C in AMPAR physiol

175 129X1/SvJ, FVB/NJ, or DBA/1J showed improved spatial learning, but TTA expression caused subtle diffe

176 through which to view conditions that impair spatial learning by altering place cell firing rates or

177 GABA(B) receptors exert a tight control over spatial learning by modulating neuronal excitability in

178 neurogenesis show normal object recognition, spatial learning, contextual fear conditioning and extin

179 (IFN-gamma) signaling in microglia underlies spatial-learning defects via virus-target-specific mecha

180 ility of compensatory phenomena, namely that spatial learning deficiencies may be mitigated through e

181 n-1 effectively rescued the autistic and non-spatial learning deficit cognitive phenotypes.

182 at early and progressive obesity potentiated spatial learning deficits as well as hippocampal tau pat

183 rats with n-3 fatty acid deficiency display spatial learning deficits in the Barnes circular maze.

184 ation of neurofibromin-dependent pathways to spatial learning deficits in the En2 mouse model of ASD.

185 (2)O anesthesia at 18-months-old, leading to spatial learning deficits in these animals.

186 reduction had thermally evoked seizures and spatial learning deficits, but they did not have abnorma

187 ired NMDA-dependent long-term depression and spatial learning deficits.

188 educed seizure and excitotoxicity and normal spatial learning exhibited in TRPC5 KO mice suggest that

189 wild-type animals, and worsens impairment in spatial learning following chronic hippocampal Abetao in

190 ious studies on the postnatal development of spatial learning have most likely assessed the ontogeny

191 During spatial learning, hippocampal (HPC) place maps reorganiz

192 seizures and restored behavioral deficits in spatial learning, hyperactivity and the aggressive respo

193 eased stress-induced hyperthermia, defective spatial learning, impaired gait, and supraspinal nocicep

194 ce exhibit deficits in hippocampus-dependent spatial learning, impaired motor coordination, altered r

195 ith anesthesia at 18-months-old demonstrated spatial learning impairment corresponding to acute and l

196 R-mediated basal synaptic transmission and a spatial learning impairment.

197 uction of TBI rescued pattern separation and spatial learning impairments 1 mo later.

198 These findings extend previous reports of spatial learning impairments after fornix transection in

199 ed rats that demonstrated anesthesia-induced spatial learning impairments.

200 One-trial spatial learning in a delayed matching to place water ma

201 On PID 21, rats were tested for spatial learning in a Morris Water Maze.

202 avoidance and spatial memory and accelerate spatial learning in a number of memory paradigms.

203 conditioning in zebrafish and attention and spatial learning in a pulse gymnotiform fish.

204 We conducted cognitive evaluation using spatial learning in a water maze and exploration behavio

205 39) impaired object recognition learning and spatial learning in a water maze task, demonstrating the

206 We provide evidence that spatial learning in CD is characterized by disturbances

207 Importantly, exogenous d-serine improves spatial learning in epileptic animals.

208 ng; however, the hippocampal neural basis of spatial learning in humans remains unclear.

209 t the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/

210 explored the effects of theta precession on spatial learning in our virtual ensembles.

211 ry replay observed in the hippocampus during spatial learning in rodents.

212 ly, there were marked changes in anxiety and spatial learning in SFD/TFD groups.

213 onth-old male 3xTg/SPKO mice restored normal spatial learning in the Barns maze, LTP in hippocampal s

214 the same time, the ghrelin agonist improved spatial learning in the mice, raised their activity leve

215 Carf KO mice show normal spatial learning in the Morris water maze and normal con

216 to monitor neuronal activation triggered by spatial learning in the Morris water maze.

217 ymptomatic stage show significantly improved spatial learning in the radial arm water maze test.

218 endritic plasticity of adult-born neurons as spatial learning in the water maze sculpts the dendritic

219 cognition were uncorrelated with deficits in spatial learning in the water maze, a task that requires

220 and striatal areas involved in reward-based spatial learning in unmedicated adults with obsessive-co

221 sed to investigate the mechanisms underlying spatial learning in vertebrates and has yielded much inf

222 ocampal characteristics were examined; i.e., spatial learning, in vitro synaptic plasticity, in vivo

223 thin the hippocampus, and we have shown that spatial learning induces expression of the transcription

224 Spatial learning is impaired in humans with preclinical

225 Spatial learning is one of the most widely studied cogni

226 h humans and rats suggests that just 2 hr of spatial learning is sufficient to change brain structure

227 ssion-like behavior or hippocampal-dependent spatial learning, it leads to an amplified and prolonged

228 e of complex behaviors, including social and spatial learning; lesion studies show that these abiliti

229 wed reduced exploratory behaviors and subtle spatial learning memory impairments were observed.

230 strated that periodic E2 treatments improved spatial learning, memory and ischemic neuronal survival

231 xpressed in areas of the brain important for spatial learning, memory, and attention.

232 ell-deficient mice have profound deficits in spatial learning, memory, and neurogenesis.

233 nt of hippocampal long-term potentiation and spatial learning-memory defects in Kcna1-null mutants, a

234 lo-HSCT recipients with GVHD had deficits in spatial learning/memory and demonstrated increased anxio

235 In this study, we examined both spatial learning/memory and hippocampal long-term potent

236 Impaired spatial learning/memory and markedly reduced LTP were fo

237 mk2a-expressing neurons (Ctcf CKO mice) have spatial learning/memory deficits, impaired fine motor sk

238 In contrast, only male Nf1 GEM showed spatial learning/memory deficits, increased Ras activity

239 Spatial learning/memory was assayed using an automated r

240 re viable and exhibited profound deficits in spatial learning/memory, impaired motor coordination, an

241 chondrial and neuronal function and improves spatial learning/memory.

242 ) activity, and accelerated deterioration of spatial learning/memory.

243 ce completely lacking RGS14 exhibit enhanced spatial learning, mice carrying variant LR exhibit norma

244 l outcome (lowered mNSS and foot faults) and spatial learning (MWM test).

245 impairments in both CA1 hippocampal LTP and spatial learning observed on the morning of proestrus ar

246 When applied during spatial learning of new goal locations, dopaminergic pho

247 ntly, APP/PS1/delta(D910A) mice exhibited no spatial learning or memory deficits.

248 mPFC inactivation did not impair spatial learning or retrieval per se, but impaired the a

249 We used water-maze (WM) training as a spatial learning paradigm to test our hypothesis.

250 Concurrently, fat-1 mice exhibit a better spatial learning performance in the Morris water maze co

251 HJ6.3 mildly improved spatial learning performance in the water maze, restored

252 ampal neurogenesis in rodents contributes to spatial learning performance, and in monkeys we found th

253 During spatial learning, place-related firing patterns in the C

254 provides a useful working description of the spatial learning process.

255 Moreover, increased levels of IL-4 improved spatial learning, promoted phosphorylation of N-methyl-D

256 In a test of spatial learning, PRRSV piglets took longer to acquire t

257 In humans, topographic spatial learning relies upon the parahippocampal cortex,

258 ociations highlights how distinct classes of spatial learning rely on different systems, even though

259 Spatial learning requires remembering and choosing paths

260 Spatial learning requires the hippocampus, and the repla

261 , i.p.) on the morning of proestrus improved spatial learning scores 150-300%.

262 e propose that the role of ASIC1a in LTP and spatial learning should be reassessed.

263 from WNV-NS5-E218A-recovered mice with poor spatial learning show increased expression of genes that

264 onic inhibition via this subunit may control spatial learning.SIGNIFICANCE STATEMENT The alpha5-GABA(

265 Impairments in spatial learning strategies in long-term reference (wate

266 ing, mice carrying variant LR exhibit normal spatial learning, suggesting that RGS14 may have distinc

267 dies in rodents have highlighted its role in spatial learning, supported by the discovery of place ce

268 that in the absence of zif268, training in a spatial learning task during this critical period fails

269 The subjects completed a spatial learning task during which they learned destinat

270 winter; and (3) cognitive performance in the spatial learning task was significantly better among the

271 Human subjects performed a 2 h spatial learning task, and rats underwent training for 1

272 oups performed similarly on the reward-based spatial learning task, we identified disturbances in bra

273 y RSC inactivation disrupts performance in a spatial learning task.

274 typically considered a hippocampus-dependent spatial learning task.

275 ng behavioral performance on a goal-oriented spatial learning task.

276 h these lesions were impaired on a series of spatial learning tasks, namely delayed-matching-to-place

277 gicus) movement characteristics on analogous spatial learning tasks.

278 in several hippocampus-dependent contextual/spatial learning tasks.

279 type (WT) and En2(-/-) mice before and after spatial learning testing.

280 LXRs exhibit altered motor coordination and spatial learning, thinner myelin sheaths, and reduced my

281 s are also reconfigured during goal-oriented spatial learning through modification of inputs from pyr

282 amically regulate brain functions, including spatial learning, through cytokine signaling.

283 Spatial learning thus engages circuit modifications in t

284 that weakening synaptic connections increase spatial learning times, produce topological defects in t

285 ual experience and the use of technology for spatial learning to better understand the nature of the

286 revious findings of stress impairing LTP and spatial learning to CRS modifying physical properties of

287 ble way to gain insight into how animals use spatial learning to guide their movement decisions.

288 ace is crucial to understand how animals use spatial learning to navigate across space because memory

289 rain activation associated with reward-based spatial learning versus a control condition in which rew

290 Spatial learning was assessed at 2weeks and 3months post

291 ng performance, and in monkeys we found that spatial learning was enhanced in conditions that increas

292 tual fear conditioning, as both cue fear and spatial learning were intact in these mice.

293 Sensorimotor function and spatial learning were measured.

294 LTP induction and spatial learning were robust, however, when assessed on

295 the cue-response task facilitated subsequent spatial learning, whereas experience with spatial naviga

296 ry synaptic function and deficits in LTP and spatial learning, which can be reversed by a mitogen-act

297 any one of these systems results in impaired spatial learning, while activating the nicotinic recepto

298 ter Maze is a widely used task in studies of spatial learning with rodents.

299 al connectivity, SynCAM 1 expression affects spatial learning, with knock-out mice learning better.

300 delay rather than a permanent deficiency in spatial learning without affecting the retention of long