ライフサイエンスコーパス: spatial memory

1 protein knockin (APP-KI) mice with impaired spatial memory.

2 rect evidence of natural selection acting on spatial memory.

3 gnaling could alleviate normal Hip-dependent spatial memory.

4 f local space is critical for navigation and spatial memory.

5 ocampus, which could account for deficits of spatial memory.

6 is that are linked to age-related decline in spatial memory.

7 ecially important for spatial processing and spatial memory.

8 al role in various cognitive tasks including spatial memory.

9 brain glucose uptake, GLUT4 expression, and spatial memory.

10 e iCA1-->mPFC pathway deactivation disrupted spatial memory.

11 working memory but did not affect long-term spatial memory.

12 ith the strength of the sigmoidal pattern in spatial memory.

13 CTNNB1 in parvalbumin-interneurons enhanced spatial memory.

14 itant behavioral deficits in both social and spatial memory.

15 four conceptually different dynamic maps of spatial memory.

16 , including episodic memory, navigation, and spatial memory.

17 receptor to regulate object recognition and spatial memory.

18 overty predicts deficits in adult short-term spatial memory.

19 rhinal region improved the accuracy of human spatial memory.

20 environment structure, gravity, movement and spatial memory.

21 gnificant deficits in object recognition and spatial memory.

22 eral assays related to episodic, working and spatial memory.

23 al neurons is a key component of working and spatial memory.

24 -term potentiation and hippocampus-dependent spatial memory.

25 episodic memory generally but to allocentric spatial memory.

26 to the processing of wake and SWS-associated spatial memory.

27 VGF knock-out mice have impaired fear and spatial memory.

28 may be associated with improvement in visual-spatial memory.

29 directly mediated actions of inflammation on spatial memory.

30 e hippocampal system, a mechanism needed for spatial memory.

31 and efferent partners, and regaining of lost spatial memory.

32 regions have been shown to be important for spatial memory.

33 hose expressed dorsally selectively affected spatial memory.

34 mechanism for Scn1a gene mutation to impair spatial memory.

35 et a posterior-medial network that subserves spatial memory.

36 ng a trade-off between visual processing and spatial memory.

37 frontal cortex are known to be important for spatial memory.

38 y role in the formation and consolidation of spatial memories.

39 wed treated eFSE rats to encode and retrieve spatial memories.

40 n and/or retrieval of precise contextual and spatial memories.

41 and are associated with the consolidation of spatial memories.

42 ts are characterized by accelerated decay of spatial memories.

43 REM) sleep(1-8) and whose disruption impairs spatial memory(3,5,6,8).

44 ppocampal ACSS2 expression impairs long-term spatial memory, a cognitive process that relies on histo

45 ver, a link between reproductive fitness and spatial memory ability has yet to be demonstrated in any

46 itive cells in the hippocampus, and improved spatial memory acquisition versus vehicle.

47 Few genes correlated with spatial memory across age groups, with a greater number

48 SF) to understand how resource selection and spatial memory affect space use of feral hogs (Sus scrof

49 activation in turn prevented impairments in spatial memory after RSD but did not prevent deficits in

50 the human hippocampus, long known to support spatial memory, also plays a causal role in model-based

51 lammatory cytokine production and subsequent spatial memory alteration.

52 his study examined allocentric (world-based) spatial memory, an important cognitive tool for planning

53 opeptidase (IRAP) enhance fear avoidance and spatial memory and accelerate spatial learning in a numb

54 Simulated night-shift work impaired spatial memory and altered biochemical markers of cerebr

55 Echolocating bats have excellent spatial memory and are able to navigate to salient locat

56 emerged in younger APP-KI mice, although the spatial memory and CA1 remapping of the animals remained

57 Significant improvements in immediate spatial memory and driving performance were observed aft

58 Depolarization of MECII impaired spatial memory and elicited drastic changes in CA1 place

59 ce [5-7] in the spatial domain to compromise spatial memory and evaluated the impact of adding an olf

60 Cognitive deficit was found in spatial memory and exploration behavior in both occluded

61 Testing spatial memory and hippocampal long-term potentiation re

62 histone acetylation, and display deficits in spatial memory and impaired contextual fear extinction.

63 entorhinal cortex (mEC) plays a key role in spatial memory and is one of the first areas to express

64 aque load and rescues functional deficits of spatial memory and long-term potentiation.

65 Besides, IS contributes to the impairment of spatial memory and motor coordination.

66 from dorsal hippocampal networks involved in spatial memory and navigation to neocortical networks in

67 urons found in the hippocampus that underlie spatial memory and navigation: how these neurons represe

68 ence; and (iii) early difficulties in visual-spatial memory and new learning among children in foster

69 We found that mutants exhibited improved spatial memory and reduced anxiety.

70 exposure (PAE) leads to profound deficits in spatial memory and synaptic and cellular alterations to

71 mice were impaired in locomotor activity and spatial memory and were resistant to seizure induction.

72 play a role in the offline consolidation of spatial memories, and in the generation of vivid percept

73 gly modulates hippocampal activity, disrupts spatial memory, and alters object-location processing.

74 estrous cycle modulates the impact of MAS on spatial memory, and fluctuating physiological levels of

75 experienced delayed motor recovery, impaired spatial memory, and increased anxiety through 8 wk posts

76 KO) exhibit defects in synaptic plasticity, spatial memory, and increased anxiety-related behaviors-

77 c, chromatin remodeling and Rac1 expression, spatial memory, and long-term potentiation (LTP) abnorma

78 on system, we investigated anxious behavior, spatial memory, and metabolic functions of conditional k

79 phisticated behaviors relating to predation, spatial memory, and visual recognition comparable to tho

80 fic, rapid, acute, and measurable deficit in spatial memory, and we speculate that gut alterations co

81 ampus computes diverse information involving spatial memory, anxiety, or reward and directly projects

82 model, hippocampal place fields that support spatial memories are abnormal at old age (7-9 months) wh

83 Conversely, regions associated with spatial memory are expanded in solitary species and thos

84 Olfactory and spatial memory are resistant to interference from the ad

85 us midbrain and pons, yet R222 showed normal spatial memory as compared to age-matched controls.

86 ng the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze.

87 ronic study, IL-1Ra-TBI mice showed improved spatial memory at 4 months post-injury.

88 elevated anxiety-like behavior and impaired spatial memory at remote time points, reminiscent of chr

89 lexibility and diversity have been linked to spatial memory, attention and task performance, the cell

90 ylase inhibitor vorinostat not only restored spatial memory, but also exerted antiinflammatory action

91 ed G-1 from enhancing object recognition and spatial memory, but the ERK inhibitor U0126 did not.

92 prefrontal cortex, are important for rodent spatial memory, but their potential role in executive fu

93 o, we find that DNRAb-mediated disruption of spatial memory characterized by early neuronal cell deat

94 In the dentate gyrus - a key component of spatial memory circuits - granule cells (GCs) are known

95 ted place-cell reactivations are crucial for spatial memory consolidation during sleep and rest.

96 and neuronal morphology lead to a deficit in spatial memory consolidation.

97 ty and enhancing both object recognition and spatial memory consolidation.

98 idirectionally regulates contextual fear and spatial memory consolidation.

99 yelination via clemastine treatment, rescues spatial memory decline during aging.

100 These spatial memory deficiencies could not be attributed to d

101 +) microglial activation correlates with the spatial memory deficit and spread of tau pathology in th

102 the acute compensation of EC lesion-induced spatial memory deficit before a slower glutamatergic rei

103 and, upon intrahippocampal injection, caused spatial memory deficit.

104 TgCRND8 mice exhibited spatial memory deficits and altered anxiety that were re

105 Furthermore, ISRIB treatment reverses spatial memory deficits and ameliorates working memory i

106 s old) rescued the early contextual fear and spatial memory deficits and decreased subsequent plaque

107 virus-mediated PGRN overexpression prevented spatial memory deficits and hippocampal neuronal loss in

108 roaggregant Tau transgenic mice restores the spatial memory deficits and normalizes the basic synapti

109 ing of APP/PS1 transgenic mice fully rescues spatial memory deficits and synaptic depletion, without

110 d, in a large sample of wild sea lions, that spatial memory deficits are predicted by the extent of r

111 t acute stresses, which might be relevant to spatial memory deficits described in posttraumatic stres

112 neurons prevents hippocampal neuron loss and spatial memory deficits in a transgenic AD mouse model w

113 stently been linked to amnesia in humans and spatial memory deficits in animal models.

114 We show that 14 prevents manifestation of spatial memory deficits in chimeric EcoHIV-infected mice

115 R192Q mice showed significant spatial memory deficits in contextual fear-conditioning

116 tumor necrosis factor alpha correlated with spatial memory deficits in middle-aged females, but not

117 ocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat mode

118 y found that daily scheduled feeding rescued spatial memory deficits in these arrhythmic animals.

119 aE9 mice that preceded previously identified spatial memory deficits in this model.

120 tering normal circuit anatomy, recapitulated spatial memory deficits observed in epileptic mice.

121 Dementia is associated with severe spatial memory deficits which arise from dysfunction in

122 -alpha(-/-) mice exhibit profound phenotypic spatial memory deficits, a DAGL inhibitor selectively im

123 ion of S6K1 improved synaptic plasticity and spatial memory deficits, and reduced the accumulation of

124 cluding sensory disturbances, and verbal and spatial memory deficits, not only in complicated HSP but

125 a congruence of dendritic spine density and spatial memory deficits, with reduced spine density only

126 pocampal-cortical networks could account for spatial memory deficits.

127 athology in the aged mice was accompanied by spatial memory deficits.

128 atly inhibited in aged mice, coinciding with spatial memory deficits.

129 ying), at the effective therapeutic dose for spatial memory deficits.

130 The extent to which navigational spatial memory depends on hippocampal integrity in human

131 However, the extent to which navigational spatial memory depends on hippocampal integrity in human

132 o enhance hippocampal object recognition and spatial memory depends on rapid activation of extracellu

133 The consolidation of spatial memory depends on the reactivation ('replay') of

134 Our data suggest that olfactory and spatial memory draw on independent working memory system

135 subsequent ripple-mediated consolidation of spatial memory during sleep.

136 tual memory during aversive conditioning and spatial memory during spontaneous exploration.

137 n hippocampal acetylcholine (ACh) efflux and spatial memory during tasks that varied in memory demand

138 ute stresses, with potential implications to spatial memory dysfunction in, for example, posttraumati

139 regions implicated in social attachment and spatial memory (e.g., periaqueductal gray, hippocampus).

140 This implies that spatial memory effects in the medium with a heterogeneou

141 iences, hogs were able to discriminate among spatial memories encoded at different circadian phases o

142 ug-place preference, showing that recoding a spatial memory engram can alleviate associated maladapti

143 ns with the allatostatin system occludes the spatial memory enhancement.

144 consolidation in other circuits, results in spatial memory enhancements.

145 gh dose caused bees to make more and earlier spatial memory errors and take longer to complete the ta

146 Verbal and spatial memory, executive function, attention, blood pre

147 Nestin-Cre mice exhibit a severe deficit in spatial memory extinction, whereas acquisition and long

148 orward intuition that these tasks just probe spatial memory fails to account for the speed at which r

149 ternatively, when mated to males with better spatial memory, females may be able to invest more in re

150 we found that TMS to the right OPA impaired spatial memory for boundary-tethered, but not landmark-t

151 condition placed a greater demand on visual-spatial memory for motion extrapolation, and thus partic

152 the MT1-MMP cytoplasmic domain in imprinting spatial memory for podosome reformation via assembly in

153 extent of experience-induced improvement of spatial memory, for the expansion of the dynamic range o

154 cal role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence

155 t DBS of the entorhinal cortex (EC) enhances spatial memory formation in normal (wild-type) mice.

156 ry for the action of cannabinoids on LTP and spatial memory formation.

157 ry inputs, long-term potentiation (LTP), and spatial memory formation.

158 n vivo, and have deleterious consequences on spatial memory formation.

159 d in synthesis in hippocampal neurons during spatial memory formation.

160 ated (BDNF-mediated) process responsible for spatial memory formation.

161 In contrast, here we show that allocentric spatial memory frequently operates over a limited spatia

162 ssive deficits in long-term potentiation and spatial memory function.

163 Chronic adipoRon treatment improved spatial memory functions and significantly rescued neuro

164 l information across the two networks during spatial memory-guided behavior.SIGNIFICANCE STATEMENT Th

165 Spatial memory had an extraordinary influence on migrati

166 Two new studies show that a good spatial memory helps birds that hide their food to survi

167 as long been implicated in both episodic and spatial memory, however these mnemonic functions have be

168 a neural systems-level mechanism to explain spatial memory impairment after moderate PAE.

169 ts with Alzheimer's disease (AD) suffer from spatial memory impairment and wandering behavior, but th

170 disruption, as circuit mechanisms underlying spatial memory impairment in AD.

171 GI produced spatial memory impairment that was ameliorated by DBS, w

172 y provides a new murine model of WNV-induced spatial memory impairment, and identifies a potential me

173 y heterozygous BDNF Val66Met females exhibit spatial memory impairment, regardless of acute stress.

174 city in vivo, resulting in hyperactivity and spatial memory impairment.

175 aberrant encoding of spatial information and spatial memory impairment.

176 tral nervous system manifestations including spatial memory impairment.

177 oring the novel arm of the Y maze because of spatial memory impairments (P < .05).

178 nimals (both male and female) displayed mild spatial memory impairments and disrupted cingulate netwo

179 stressors occurring simultaneously result in spatial memory impairments in males, but effects on fema

180 e deposition, as well as contextual fear and spatial memory impairments.

181 -guided focused ultrasound treatments led to spatial memory improvement in a Tg mouse model of AD Alz

182 and consolidation of object recognition and spatial memories in ovariectomized mice.

183 inhibition of DeltaFosB signaling, improves spatial memory in a mouse model of AD.

184 te that environmental geometry affects human spatial memory in a similar manner to rodent grid-cell a

185 impairments of pattern separation-associated spatial memory in AD mice are in part caused by degenera

186 amylin receptor antagonist, AC253, improves spatial memory in AD mouse models.

187 ired recognition memory, working memory, and spatial memory in aged FAD mice were rescued by the trea

188 VCID impaired spatial memory in both sexes, but episodic-like memory i

189 t manner: MAS impaired hippocampus-dependent spatial memory in early-proestrous mice, characterized b

190 ired episodic-like memory in both sexes, but spatial memory in females only.

191 dence suggest that natural selection acts on spatial memory in food-caching species [3-6].

192 Disruptions in circadian timing impair spatial memory in humans and rodents.

193 Based on this, we theorize that spatial memory in humans develops through three advancin

194 nt a role for hippocampus in nonnavigational spatial memory in macaques and demonstrate the efficacy

195 ed with the Y5R are involved in retention of spatial memory in male and female mice.

196 duced alterations in synaptic plasticity and spatial memory in male rats.

197 regulates histone acetylation in neurons and spatial memory in mammals.

198 Spatial memory in mice was impaired enduringly after acu

199 paired both long-term potentiation (LTP) and spatial memory in mice, although endogenous SHP2 was exp

200 pal proliferation, leading to improved adult spatial memory in mice.

201 agonist G-1 enhanced object recognition and spatial memory in ovariectomized female mice, whereas th

202 iota/lambda-antagonist disrupts late-LTP and spatial memory in PKMzeta-null mice but not in wild-type

203 d neurogenesis interferes with the recall of spatial memory in rats.

204 city, neurogenesis and hippocampal-dependent spatial memory in rodents, leading to clinical trials in

205 n as declarative memory and often studied as spatial memory in rodents.

206 eptide load in the brain, alpha-MSH improves spatial memory in TgCRND8 mice and prevents alterations

207 the reduced expression prevents retention of spatial memory in the water maze.

208 Moreover, LPS injection impaired spatial memory in WT mice, whereas interestingly, the Fa

209 2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelinatio

210 at systemic pools of TIMP2 are necessary for spatial memory in young mice, while treatment of brain s

211 Interestingly, synaptic activity and spatial memory induces Crtc1 dephosphorylation (Ser151),

212 approach has shown how the incorporation of spatial memory into animal movement models can improve e

213 Here, we incorporated spatial memory into step selection functions (SSF) to un

214 In scatter-caching species, spatial memory is critical for the recovery of food cach

215 eptiles, birds, and mammals, its function in spatial memory is said to be highly conserved.

216 Spatial memory is thought to critically depend on the in

217 ctivation did enhance object recognition and spatial memory, it did so by activating different cell-s

218 tial replay in association with episodic and spatial memory, it is unknown whether similar sequences

219 w onto cognitive processing in tasks such as spatial memory, linguistic processing, and decision maki

220 2R neurons interferes with the encoding of a spatial memory linking food to a specific location via p

221 id not mitigate early-life adversity-induced spatial memory losses at 4 and 8 months, it restored hip

222 s that rely on flexible navigation, impaired spatial memory may affect survival in the wild.

223 ssment demonstrated impaired recognition and spatial memory, measured by novel object recognition and

224 arietal regions involved in multisensory and spatial memory mediate the aftereffect following both tr

225 (Rey Auditory-Verbal Learning Test), visual-spatial memory (Medical College of Georgia Complex Figur

226 es, suggesting that they are combined in the spatial memory network in the beetle's brain.

227 upon the demonstrated therapeutic effects on spatial memory of bryostatin-1, a relatively specific ac

228 neurons in brain structures that instantiate spatial memory often exhibit firing fields that are stro

229 portance of land cover type, time of day and spatial memory on the animals' space use.

230 ic topology, how such a network can maintain spatial memory over time.

231 ythmicity and changes in sleep drive predict spatial memory performance and expression of brain prote

232 restored phosphorylation of beta-CaMKII and spatial memory performance in APP/PS1 Ear2(-/-) mice.

233 activation after psychosocial stress impairs spatial memory performance independent of deficits in ne

234 Following three work shifts, spatial memory performance was tested on the Morris Wate

235 In summary, minocycline impaired human spatial memory performance, likely through disruption of

236 EB signaling in the hippocampus and impaired spatial memory performance, while optoA2AR activation in

237 ding seizures, premature death, and impaired spatial memory performance.

238 functional impairment in the form of reduced spatial memory performance.

239 t correlated with an impaired contextual and spatial memory performance.

240 ng in a complete rescue of the life span and spatial memory performance.

241 terns of connectivity tracked item color and spatial memory precision.

242 the gene avpr1a) in brain regions related to spatial memory predict male space use and sexual fidelit

243 Here we identified significant, enduring spatial memory problems in male rats following experimen

244 For migratory terrestrial mammals, spatial memory provides knowledge of where seasonal rang

245 n of memory processes, selectively modulates spatial memory recall of stressful experiences.

246 ere that RSD caused transient impairments in spatial memory recall that resolved within 28 d.

247 ntal frame syncing) plays a critical role in spatial memory recollection.

248 s for five weeks in aged 5XFAD mice improved spatial memory, reduced amyloid plaque burden, and neuro

249 beta + EB) groups failed to improve episodic spatial memory relative to oil-treated animals, indicati

250 relationship between RSC firing patterns and spatial memory remains largely unexplored, as previous p

251 As spatial memory requires an intact dorsal hippocampal CA1

252 Spatial memory requires hippocampal sharp-wave ripples (

253 ze tests, which measure short- and long-term spatial memory, respectively.

254 loss of Lphn2 from the CA1 region increased spatial memory retention but decreased learning of seque

255 ed to their sham controls without exhibiting spatial memory retention deficits.

256 Impairments in object recognition, spatial memory retention, and network stability followin

257 ore, modality-independent network supporting spatial memory retrieval in the human brain.

258 ys a key role in the selective regulation of spatial memory retrieval of stressful experience, sheddi

259 orm elimination and suggest that finer tuned spatial memory studies be carried out in humans.

260 proper storage and retrieval of episodic and spatial memories, suggesting that hippocampal signaling

261 hifting the balance in favor of the DH-based spatial memory system, although the precise region of AR

262 cit hippocampal-prefrontal theta coupling: a spatial memory task (during magnetoencephalography) and

263 on, participants performed a virtual reality spatial memory task analogous to the Morris water maze a

264 hizophrenia, who were mildly impaired at the spatial memory task and no better than chance on the mem

265 ted mice performed a classical goal-directed spatial memory task in a rectangular chamber.

266 al epilepsy patients performing a self-paced spatial memory task in a virtual environment.

267 f performance in a working memory task and a spatial memory task in rodents and nonhuman primates, re

268 Despite learning a spatial memory task normally and displaying normal brain

269 Here we trained rats on a spatial memory task, and showed that subsequent sleep pe

270 We demonstrate-in the spatial memory task, during memory recall-that theta pow

271 ent to bias the behavior of animals during a spatial memory task, providing causal evidence that hipp

272 In the spatial memory task, rats searched for a depleting food

273 Additional effects of HT-0712 were seen in a spatial memory task.

274 als while neurosurgical patients performed a spatial memory task.

275 ng in rats during a free-foraging task and a spatial memory task.

276 nts playing Treasure Hunt, a virtual-reality spatial-memory task.

277 -locked to hippocampal theta oscillations in spatial memory tasks, whether and how theta oscillations

278 tention but decreased learning of sequential spatial memory tasks.

279 red long-term depression and performances on spatial memory tasks.

280 However, a spatial memory test in the forms of the Morris water maz

281 well as dysfunctional hippocampus-dependent spatial memory tested in the object-placement and the Y-

282 n, novel object recognition, and Barnes maze spatial memory tests.

283 cement in long-term depression, and weakened spatial memory, these changes were not observed in oxyto

284 control hippocampal synaptic plasticity and spatial memory through the hyperpolarization-activated c

285 ells are engaged during the consolidation of spatial memories to the neocortex.

286 s, restored both postnatal proliferation and spatial memory to normal levels.

287 data suggests that vision, echolocation, and spatial memory together with the possible exercise of an

288 y in the hippocampus of APPSw,Ind mice after spatial memory training.

289 ct of trapezoidal boundary geometry on human spatial memory using immersive virtual reality.

290 rmining excitatory neuronal architecture and spatial memory via their ability to regulate Arc/Arg3.1.

291 Rat hippocampus-dependent spatial memory was evaluated on postnatal days 49-60.

292 Spatial memory was examined 48 h after EB/oil treatment.

293 sensory input from echolocation, vision, and spatial memory, we conducted an experiment in which bats

294 Despite decades of research on spatial memory, we know surprisingly little about how th

295 hippocampus is necessary for nonnavigational spatial memory, we selected a technique that avoids long

296 Age-related CA1 DEGs, correlated with spatial memory, were linked to regulation of neural acti

297 essing FKBP1b showed dramatic enhancement of spatial memory, which correlated with marked reduction o

298 Cc2d1a-deficient male mice show a deficit in spatial memory, which is not present in Cc2d1a-deficient

299 ing a suite of sensory modalities that blend spatial memory with input from vision, tactile sensing,

300 .54 [1.67], p = 0.010, respectively), visual-spatial memory (z score = -1.65 [1.37], p = 0.008; z sco