ライフサイエンスコーパス: spatial regulation

1 e mechanisms coordinating their temporal and spatial regulation.

2 lar structures requires precise temporal and spatial regulation.

3 s multiple enzymes under strict temporal and spatial regulation.

4 he inner junctions, underscoring its precise spatial regulation.

5 ign of a variety of proproteins with precise spatial regulation.

6 tions, and may thus fail to reliably capture spatial regulations.

7 frequency near centromeres, indicating that spatial regulation across chromosomal regions reduces ri

8 yl-1,4-naphthoquinone, or Compound 5, on the spatial regulation and activation kinetics of tyrosine p

9 Both transcripts also display spatial regulation and are found in the dorsal mesoderm

10 ting exhibits sexually dimorphic patterns of spatial regulation and can be modified by abiotic enviro

11 effect (itself of interest), in other cases, spatial regulation and control can profoundly affect the

12 f D(II)-state SMLM to resolve the nanoscopic spatial regulation and dynamics of single fatty acid ana

13 ties, mechanisms underlying its temporal and spatial regulation and functional plasticity still remai

14 rk reveals the structural mechanism of LRRK2 spatial regulation and provides insights into LRRK2 inhi

15 y cellular activity in adherent cells, their spatial regulation and the corresponding change in membr

16 of light to mediate these reactions permits spatial regulation and the generation of unique, multifu

17 ty, but little is known in mammals about its spatial regulation and the relevance of spatial Cdc42 po

18 uding synergistic activation, long-range and spatial regulation, and gene expression memory.

19 In bacteria, where linear motors involved in spatial regulation are absent, the ParA/MinD family of A

20 le severing and the mechanisms governing its spatial regulation are not well understood.

21 ion of active RhoGTPase contributes to their spatial regulation around cell wounds.

22 proteins show almost identical temporal and spatial regulation at the cell cortex.

23 gration of post-translational modifications, spatial regulation at the cellular level, and TGFBR avai

24 The phas promoter displays stringent spatial regulation, being very highly expressed during e

25 r gene-gene information flow to estimate the spatial regulations between genes across cells.

26 of the assembly of these polymers and their spatial regulation by accessory factors, framing them in

27 The exocyst complex seems to achieve this spatial regulation by determining the sites at the membr

28 We independently confirmed insulin-dependent spatial regulation by using static spatial statistics me

29 mplex subcellular localization, yet how MCAK spatial regulation contributes to spindle assembly is no

30 Thus, in addition to temporal and spatial regulation, dosage-dependent threshold requireme

31 ression of sigmaH is subject to temporal and spatial regulation during colony development, that this

32 ep tissues, however ov1aS shows temporal and spatial regulation during fetal lung development, being

33 the poised enhancer state may be a mark for spatial regulation during tissue patterning.

34 Temporal and spatial regulation have emerged as the central themes, w

35 se in cardiomyocytes is most consistent with spatial regulation in microdomains of the plasma membran

36 ing technology to gain new information about spatial regulation in signaling events.

37 to be learned about cellular engineering and spatial regulation in these 'simple' cell wall-less bact

38 xtreme periphery of microcolonies, mimicking spatial regulation in tissues.

39 dition to temporal control of BarA activity, spatial regulation is demonstrated.

40 vertebrate neural tube closure, however, its spatial regulation is largely unknown.

41 but the molecular mechanism underlying this spatial regulation is not understood.

42 rs and membrane signaling proteins, but this spatial regulation is not well defined.

43 essive architecture, which confers stringent spatial regulation, is disrupted upon transcriptional ac

44 dhesion cascade, and its strict temporal and spatial regulation make it an ideal target for imaging a

45 suggesting that this mechanism of cyclin-CDK spatial regulation may be conserved across eukaryotes.

46 thway via both S127 phosphorylation-mediated spatial regulation (nuclear-cytoplasmic shuttling) and t

47 e that produces the ventral signal, but that spatial regulation occurring downstream of Nudel proteas

48 of this study was to further investigate the spatial regulation of [Ca(2+)](i) clearance in parotid a

49 or this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response

50 that five of these are each dedicated to the spatial regulation of a single cellular cargo, and defin

51 aling components in lipid rafts provides key spatial regulation of AC activity.

52 te how microtubules contribute to the proper spatial regulation of actin assembly and polarized cell

53 pecific roles of different actin isoforms in spatial regulation of actin dynamics and stability in ax

54 be novel mechanisms of cofilin severing and spatial regulation of actin filament turnover in cells.

55 We describe an approach for analyzing spatial regulation of actin polymerization and depolymer

56 Microtubules (MTs) participate in the spatial regulation of actin-based processes such as cyto

57 s indicate that both GAPs collaborate in the spatial regulation of active Cdc42.

58 These results show that tight spatial regulation of actomyosin contractility is requir

59 a demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex

60 Together, we show that spatial regulation of ADF/cofilin activity controls the

61 r heme synthesis, offering insights into the spatial regulation of ALAS2 and the maturation of the es

62 This allosteric spatial regulation of alpha-TAT1 function may help uncov

63 ta suggest a molecular model of temporal and spatial regulation of alphaB, alphaA and gamma-crystalli

64 neural precursor formation suggests that the spatial regulation of an AS-C gene was modified during L

65 ffects of absent blood flow include abnormal spatial regulation of angiogenesis and elevated VEGF sig

66 ngly bind ankB in the distal axon because of spatial regulation of ankyrin affinity by phosphorylatio

67 king pathways, but little is known about the spatial regulation of ARF activation.

68 B, but the mechanism and significance of the spatial regulation of Aurora B activity remain unclear.

69 provide a mechanistic theoretical model for spatial regulation of Aurora B phosphorylation.

70 Our data provide a novel model for the spatial regulation of axon branching by Netrin-1, in whi

71 est that to achieve the precise temporal and spatial regulation of BB/centriole assembly, the initiat

72 Temporal and spatial regulation of beta A3/A1 expression in the lens

73 our findings indicate that Ca(2+)-dependent spatial regulation of beta-actin synthesis through Src c

74 oteins to specific condensates, enabling the spatial regulation of biochemistry within the cell.

75 ions to invadopodia through the temporal and spatial regulation of c-Src activity.

76 Such tight spatial regulation of Ca(2+) efflux is likely important

77 The temporal and spatial regulation of Ca2(+) is crucial for the precise

78 and ACA5 to the vacuole membrane, providing spatial regulation of calcium efflux.

79 ease, elevated calcium levels, and disrupted spatial regulation of calcium signaling during spermathe

80 However, the precise temporal and spatial regulation of CaMKII activity in living cells ha

81 muialpha can be used to observe temporal and spatial regulation of CaMKII activity in living neurons.

82 diomyocytes and elicit differential temporal/spatial regulation of cAMP signaling.

83 d covalent contributions thus compete in the spatial regulation of capsid architecture.

84 ic pattern along the root's axis, suggesting spatial regulation of carotenoid synthesis.

85 hese data are consistent with a temporal and spatial regulation of Cdc24p-dependent activation of Cdc

86 cam1 controls neuronal morphogenesis through spatial regulation of Cdc42 signaling and, subsequently,

87 l eukaryotic cells [1], and the temporal and spatial regulation of Cdc42p depends on the activity and

88 and other observations, we propose that the spatial regulation of Cdc5p by cohesin modulates condens

89 method will accelerate understanding of the spatial regulation of cell and tissue functions.

90 se findings indicate that in eye development spatial regulation of cell death and survival is integra

91 Temporal and spatial regulation of cell division assures that each da

92 Spatial regulation of cell division in Escherichia coli

93 Temporal and spatial regulation of cell division is critical for prop

94 component of the Min system involved in the spatial regulation of cell division.

95 In multicellular organisms, temporal and spatial regulation of cell proliferation is central for

96 tural filamentous proteins necessary for the spatial regulation of cell shape, cell division, and chr

97 s PG splitting process requires temporal and spatial regulation of cell wall hydrolases.

98 ch as length or curvature, arise through the spatial regulation of cell wall synthesis by cytoskeleta

99 In particular, the spatial regulation of cellular processes can be examined

100 rs, are critical for the proper temporal and spatial regulation of cellular proliferation.

101 ce elements responsible for the temporal and spatial regulation of CFTR expression.

102 aising the possibility that the temporal and spatial regulation of chitin synthesis is mediated by th

103 The temporal and spatial regulation of chitin synthesis was investigated

104 activation of myosin II isoforms to mediate spatial regulation of CIE, possibly by modulation of loc

105 Thus, spatial regulation of classical cadherin adhesive functi

106 ith the coagulation system, the temporal and spatial regulation of coagulation activity in neuroinfla

107 To better understand the spatial regulation of cohesin association, we mapped bud

108 gration driven by Endo180 as a model for the spatial regulation of contractility and adhesion dynamic

109 rent feed-forward loop that converges on the spatial regulation of CYCP3;1 and CYCP3;2 expression.

110 e Escherichia coli Min system contributes to spatial regulation of cytokinesis by preventing assembly

111 chia coli, the Min system contributes to the spatial regulation of cytokinesis by preventing the asse

112 d1) and discordia2 (dcd2), which disrupt the spatial regulation of cytokinesis during asymmetric cell

113 cal to the oscillatory mechanism involved in spatial regulation of division.

114 act as a dynamic and sensitive mechanism for spatial regulation of DNA transactions in vivo by select

115 gs for understanding the transcriptional and spatial regulation of dysfunctional T cells and for the

116 Together, these data indicate that spatial regulation of EGFR signaling may be an important

117 tion of ILVs within the MVB and thus for the spatial regulation of EGFR signaling.

118 Loss of the normal spatial regulation of eph/ephrin expression in val mutan

119 ardiomyocytes and unveil a mechanism for the spatial regulation of ER-PM contacts through PM curvatur

120 lts reveal a non-canonical mechanism for the spatial regulation of ERK through GPCR signalling and id

121 ture-dependent assembly pathway provides the spatial regulation of ESCRT-III to fuse juxtaposed bilay

122 geneity of leukocytes in infected tissues by spatial regulation of ether-linked phospholipids contain

123 0 component of the exocyst is a key event in spatial regulation of exocytosis by Rho GTPases.

124 Temporal and spatial regulation of expression of introduced genes, or

125 d proteins and/or via changes in temporal or spatial regulation of expression.

126 anscription machinery to accomplish rigorous spatial regulation of expression.

127 se prosaposin displayed similar temporal and spatial regulation of expression.

128 Cell motility universally relies on spatial regulation of focal adhesion complexes (FAs) con

129 These observations suggest that the precise spatial regulation of FORSE-1 binding in the embryonic f

130 MinCDE system indeed is sufficient to cause spatial regulation of FtsZ, required for Z-ring position

131 This spatial regulation of FZD expression constitutes a previ

132 This is likely due to the temporal and spatial regulation of GA biosynthesis, perception, and s

133 We present evidence that the spatial regulation of GAL1 and CLN3 transcripts is what

134 scores the need for the precise temporal and spatial regulation of gcm transcription.

135 Developmental changes in the temporal and spatial regulation of gene expression drive the emergenc

136 Precise temporal and spatial regulation of gene expression during Drosophila

137 The temporal and spatial regulation of gene expression in mammalian devel

138 id phase separation (LLPS), are critical for spatial regulation of gene expression in the cytoplasm.

139 EFb has evolved for the precise temporal and spatial regulation of gene expression in the organism.

140 Selective spatial regulation of gene expression lies at the core o

141 Spatial regulation of gene expression time delays is a n

142 r shape is correlated with both temporal and spatial regulation of gene expression.

143 an extensive analysis of transcriptional and spatial regulation of gene expression.

144 ks of transcription factors to ensure robust spatial regulation of gene expression.

145 and tissue-specific transcription factors to spatial regulation of gene expression.

146 e uncover the fundamental role of MVI in the spatial regulation of gene expression.

147 ast 17 clock neuron categories with striking spatial regulation of gene expression.

148 the skeleton relies on precise temporal and spatial regulation of genes expressed in cartilage and b

149 at Cdc42 regulates cell polarity through the spatial regulation of GSK-3beta and Apc.

150 r its functions in vivo and propose that the spatial regulation of Gwl at mitotic entry contributes t

151 thus suggesting a role for autoprocessing in spatial regulation of hh signaling.

152 RNA hybridization analysis, the temporal and spatial regulation of HMG1, one of the genes encoding HM

153 e that is indispensable for the temporal and spatial regulation of host response and, together with i

154 system represents a useful tool for studying spatial regulation of IL-1beta production in skin.

155 signaling proteins and provide temporal and spatial regulation of intracellular Ca(2+) in different

156 ontext, Rab5a plays an important role in the spatial regulation of intracellular transport and signal

157 these novel insights help to understand the spatial regulation of intracellular transport.

158 Few successes have been seen in achieving spatial regulation of ion flow through external control.

159 Further, temporal and spatial regulation of irreversible post-translational mo

160 ulates RNR activity through the temporal and spatial regulation of its subunits.

161 ever, little is known about the temporal and spatial regulation of its synthesis.

162 nes in the CNS, we examined the temporal and spatial regulation of key signal transducers and activat

163 Here, we discuss the spatial regulation of kinases, the tools used to detect

164 stasis, and establish the importance of fine spatial regulation of lipid biosynthesis for cellular fu

165 Spatial regulation of lipids was also investigated using

166 his evidence reveals previously unidentified spatial regulation of macromolecular crowding and spatia

167 es and can be used to probe the temporal and spatial regulation of macrophage metabolism during tissu

168 Spatial regulation of maternal RNA translation, which ha

169 A, and we propose that it contributes to the spatial regulation of MCAK activity within inner centrom

170 ular compartmentalization is integral to the spatial regulation of mechanistic target of rapamycin (m

171 t microdomains, and provide insight into the spatial regulation of membrane invagination.

172 Spatial regulation of microtubule (MT) dynamics contribu

173 We show that the spatial regulation of microtubule catastrophe parameters

174 eveal that A. nidulans exhibits a remarkable spatial regulation of microtubule disassembly within hyp

175 a unique and quantitative approach to study spatial regulation of microtubule dynamics in cells.

176 In a refined model, we added spatial regulation of microtubule stability and minus-en

177 e formation provides the molecular basis for spatial regulation of microtubule-based processes by tau

178 ery controls membrane ruffling, and that the spatial regulation of MLC phosphorylation plays critical

179 st that ROCK and MLCK play distinct roles in spatial regulation of MLC phosphorylation.

180 These mechanisms of functional and spatial regulation of MMP-2 may also be applicable to di

181 also enhanced catalytic activity due to the spatial regulation of MNPs as close as possible to the M

182 A potential mechanism for spatial regulation of motor proteins is provided by post

183 engaged for local protein production and how spatial regulation of mRNA-protein interactions mediates

184 Finally, we briefly touch on the spatial regulation of mRNAs in translational control.

185 Thus, spatial regulation of myosin motor function is in part c

186 Our study reveals a critical step in the spatial regulation of myosin V-dependent organelle trans

187 Spatial regulation of nanos is achieved by a combination

188 temporally distinct activities contribute to spatial regulation of nanos translation.

189 in situ, providing critical insight into the spatial regulation of neuropeptide isomerization.

190 x development, emphasizing the importance of spatial regulation of nos mRNA [3, 5].

191 olated vulval precursor cell behavior and in spatial regulation of Notch activity.

192 sis of Fn1 in cardiovascular development and spatial regulation of Notch signaling.

193 Thus, an exquisite temporal and spatial regulation of Nrp1 expression determines SS inte

194 sion of NTPDases in the vasculature suggests spatial regulation of nucleotide-mediated signaling.

195 The tight spatial regulation of opponent splice variants helps ens

196 at similar mechanisms may be involved in the spatial regulation of other genes in early embryonic dev

197 rod-shaped cells to investigate the roles of spatial regulation of peptidoglycan synthesis, glycan-st

198 escribing novel features of the temporal and spatial regulation of phosphoinositides and their downst

199 leading edge, achieved through temporal and spatial regulation of PI3 kinases and the tumor suppress

200 Spatial regulation of PI4P levels thereby plays an impor

201 and others have shown that the temporal and spatial regulation of PIE-1 degradation is controlled by

202 These data demonstrate that spatial regulation of PKA via anchoring is an important

203 The results reveal striking spatial regulation of platelet activation and fibrin for

204 er, these data suggest that the temporal and spatial regulation of polarized growth converges at the

205 ORC and Cdc6 ensure the correct temporal and spatial regulation of pre-RC formation.

206 Temporal and spatial regulation of proliferation and differentiation

207 as defined a novel mechanism involved in the spatial regulation of proteasome function and provided n

208 ic development requires precise temporal and spatial regulation of protein activity.

209 s and exportins plays a critical role in the spatial regulation of protein activity.

210 In eukaryotic cells, the spatial regulation of protein expression is frequently c

211 This methodology enables spatial regulation of protein synthesis, and deciphering

212 egulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA in

213 uggesting that Hsp42 plays a central role in spatial regulation of proteins in quiescent cells.

214 ration and describes a new mechanism for the spatial regulation of Rac1 activity that is critical for

215 ular status suggests a role for Gpd1p in the spatial regulation of redox potential, a process critica

216 of SOX2 dosage is critical for temporal and spatial regulation of retinal progenitor cell differenti

217 sary for invasion, but also that subcellular spatial regulation of RhoA activity, as opposed to its g

218 Spatial regulation of RNA plays a critical role in gene

219 ts delineate a PTK7-Src signaling module for spatial regulation of ROCK activity, actomyosin contract

220 Both of these loci affect the spatial regulation of runt transcription and appear gene

221 ing vesicular release to ensure temporal and spatial regulation of serotonergic signalling and neurot

222 erochromatin and gene regulation through the spatial regulation of SETDB1-mediated H3K9me3 deposition

223 ns, and support a role for motor proteins in spatial regulation of signal transduction pathways.

224 thereby providing the first clear example of spatial regulation of signaling in this organelle that i

225 nd support the role of motor proteins in the spatial regulation of signaling modules.

226 uence-specific transcription factors and the spatial regulation of siRNA production and DNA methylati

227 e first meiotic division requires the proper spatial regulation of sister chromatid cohesion and its

228 ns on VAMP2 structure and sheds light on the spatial regulation of SNARE assembly.

229 To dissect the spatial regulation of specific 3-PI species, we develope

230 siological adjustments in quiescent cells is spatial regulation of specific proteins and RNA importan

231 Previous studies support a model in which spatial regulation of SpHE transcription relies on multi

232 ivation, a mechanism that contributes to the spatial regulation of spindle assembly and possibly to o

233 reviously unrealized mitotic roles involving spatial regulation of spindle assembly checkpoint (SAC)

234 in three-dimensional scaffolds could enable spatial regulation of stem cell differentiation and bone

235 us reactions, but the on-demand, temporal or spatial regulation of such processes by external trigger

236 Better understanding of the spatial regulation of surface anchoring may lead to the

237 smata reveals there is distinct temporal and spatial regulation of symplastic domains at the apex, de

238 This mechanism also ensures spatial regulation of Tfp, explaining how MglA switching

239 cognitive deficits, supporting that precise spatial regulation of TGF-beta1 ligand derived from micr

240 fication of lateral organ fate relies on the spatial regulation of the ABC floral organ identity gene

241 Temporal and spatial regulation of the actin cytoskeleton is vital fo

242 romoter in order to examine the temporal and spatial regulation of the ANF gene in vivo using transge

243 e concept that highly curved membranes drive spatial regulation of the autophagosome biogenesis durin

244 ing cochlear duct relies on the temporal and spatial regulation of the bHLH transcription factor Atoh

245 Spatial regulation of the cAMP-dependent protein kinase

246 We examine the temporal and spatial regulation of the Caulobacter cell cycle, bacter

247 Defects in spatial regulation of the cell attachment at the leading

248 s in our understanding of the components and spatial regulation of the contractile ring (CR), the pre

249 In many bacteria, MinD is involved in spatial regulation of the cytokinetic Z ring, and ParAs

250 eading to a coupled oscillation required for spatial regulation of the cytokinetic Z ring.

251 nterplay between elements is involved in the spatial regulation of the genes present on the pregenomi

252 The nanotubular confinement allows spatial regulation of the mass transport of nitrogen dur

253 MLC and SM-alpha-actin are consistent with a spatial regulation of the myosin-actin apparatus in the

254 m (CNS), the molecular mechanisms underlying spatial regulation of the neuropeptide genes are largely

255 shading in fish, and that this depended upon spatial regulation of the numbers of each chromatophore

256 The precise temporal-spatial regulation of the p21-activated serine-threonine

257 Spatial regulation of the plant hormone indole-3-acetic

258 and the Sox-domain protein Dichaete, to the spatial regulation of the proneural gene achaete (ac) in

259 fusion protein function can be controlled by spatial regulation of the proteolytic priming site, with

260 of SUMO-1 conjugation to RanGAP1 may be the spatial regulation of the Ran pathway during mitosis.

261 Temporal and spatial regulation of the replication factory is importa

262 We propose that spatial regulation of the SAX pathway modulates TKV sign

263 and reveal diverse localization patterns for spatial regulation of the transcriptome in complex tissu

264 thus reveals novel inhibitory functions and spatial regulation of the ubiquitin-independent proteaso

265 xo-cycling synaptic vesicle pool and loss of spatial regulation of the vesicular recycling intermedia

266 nd in the case of MinC were shown to mediate spatial regulation of the Z ring demonstrating that MinC

267 oRNA loss-of-function phenotypes, define the spatial regulation of their effectors and uncover intera

268 n vivo would be more feasible if temporal or spatial regulation of their enzymatic activity were poss

269 ese genes are determined by the temporal and spatial regulation of their expression patterns.

270 However, little is known about the spatial regulation of their synthesizing machinery.

271 Even though the temporal and spatial regulation of these integrin clusters is essenti

272 actin track influence the motor activity and spatial regulation of these myosins.

273 Spatial regulation of this pathway is determined by the

274 h alternative splicing, and the temporal and spatial regulation of those isoforms is critical for org

275 These results indicate that the spatial regulation of TOR complex 1 (TORC1) might be inv

276 identify Ack1 as an essential player in the spatial regulation of TRAIL-R1/2.

277 lopment requires well-organized temporal and spatial regulation of transcription factors that are ass

278 itions, mediated in part by the temporal and spatial regulation of transcription factors.

279 ansgenic approaches we achieved temporal and spatial regulation of transgene expression and performed

280 ne control systems that provide temporal and spatial regulation of transgene expression in response t

281 The spatial regulation of Trk processing is thought to be me

282 Spatial regulation of tyrosine phosphorylation is import

283 the Vac17 adaptor at the bud cortex provides spatial regulation of vacuole release.

284 ng protein that is required for temporal and spatial regulation of vascular endothelial growth factor

285 The results show a complex temporal and spatial regulation of vn transcription involving multipl

286 kinesin-8 motor Kip3p plays a minor role in spatial regulation of yeast kMT assembly.

287 This cooperativity may confer temporal and spatial regulation on HIV-1 assembly.

288 ation, particularly in terms of temporal and spatial regulation, over a wide range of biological syst

289 upting these interactions shows that altered spatial regulation rather than reduced Grem1 transcript

290 t factors, but its biochemical mechanism and spatial regulation remain poorly understood.

291 olecular signals, phosphorylation events and spatial regulation renders this fascinating organelle an

292 s are controlled in an additive manner while spatial regulation requires synergistic interactions amo

293 in centomeric regions suggests temporal and spatial regulation roles for H2A phosphorylation in chro

294 This tight temporal-spatial regulation suggests that FMRP plays a dynamic ro

295 This spatial regulation suggests that these filaments have ad

296 lex pattern of expression, with temporal and spatial regulation that is not accounted for by elements

297 d in nuclear speckles, adding a component of spatial regulation to co-/post-transcriptional splicing.

298 For spatial regulation, transgenes were expressed by using p

299 To define the relevance of this spatial regulation, we developed an in vitro invasion as

300 branes beyond the plasma membrane, yet their spatial regulation within other membrane compartments is