ライフサイエンスコーパス: spatiotemporal

1 nce, knock-in and knock-out, lack sufficient spatiotemporal accuracy, while optogenetic tools suffer

2 With this data, we reconstructed spatiotemporal activation maps of A1 and estimated the l

3 Here, we examine the spatiotemporal activation of actin regulators, including

4 owever, the precise mechanisms governing the spatiotemporal activation of these two signaling pathway

5 To test this, we measured how the spatiotemporal activation patterns of A1 changed when na

6 Gdf5-LacZ reporter mouse lines to assess the spatiotemporal activity of Gdf5 regulatory sequences in

7 pMCAo with minor differences from baseline, spatiotemporal analyses of spontaneous activity revealed

8 d RNA will likely facilitate high-resolution spatiotemporal analysis of complex RNA processes.

9 logy of the claustrum to be studied with the spatiotemporal and cell type-specific precision required

10 and self-ratings of sensory/motor/cognitive/spatiotemporal and emotional characteristics of the imag

11 is higher in metazoan genomes, suggesting a spatiotemporal and functional specialization in higher e

12 ight to control biological processes at high spatiotemporal and quantitative resolutions, in a revers

13 light-responsive ionic conductivity enables spatiotemporal and reversible patterning of PIL films us

14 Importantly, our spatiotemporal approach also allows for the systematic e

15 compared to the state-of-the-art technique (spatiotemporal based registration).

16 Here we explore the generation of dynamic spatiotemporal beams that combine these two forms of orb

17 Spatiotemporal bias in genome sampling can severely conf

18 Our study reveals that spatiotemporal cAMP signaling is under precise control o

19 lar matrix control their bioavailability and spatiotemporal cellular signalling.

20 Both processes were indexed by systematic spatiotemporal changes in beta-burst rates.

21 ions via sequence specific motifs to measure spatiotemporal changes in ERK activity.

22 This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI sig

23 itutes the first quantitative mapping of the spatiotemporal changes of spinal cord tissue stiffness i

24 ectedly robust autonomous clock with unusual spatiotemporal characteristics in core and noncore clock

25 Thus, the spatiotemporal characteristics of Type II cells and thei

26 We applied SP-CUP to the spatiotemporal characterization of linear polarization d

27 vironment, have been widely investigated for spatiotemporal chemotherapeutic drug release application

28 ging of the sciatic nerve, we deciphered the spatiotemporal choreography of resident and recently rec

29 ally phased activity, creating stereotypical spatiotemporal circadian waves of cellular activation ac

30 ent patterns, spatial changes, outliers, and spatiotemporal clusters.

31 Singular value based spatiotemporal clutter filtering (SVD-STF) improves the

32 multifractal graph model to characterize the spatiotemporal complexity and heterogeneity encoded in t

33 These findings reveal greater spatiotemporal complexity in phenological responses than

34 he interior of the colony, as predicted by a spatiotemporal computational model.

35 s photoactivation to interact, enabling high spatiotemporal confinement of dimerization with a single

36 odologies establish the wider ecological and spatiotemporal context within which focal biological res

37 nsed and signaled due to the lack of precise spatiotemporal control in vivo.

38 Our results uncover the spatiotemporal control of AM development through the coo

39 is important in biomaterials engineering for spatiotemporal control of biochemical processes.

40 challenging, due to difficulties in precise spatiotemporal control of deformations and inefficient u

41 Optogenetic genome engineering tools enable spatiotemporal control of gene expression and provide ne

42 ght-activated regulatory RNAs are needed for spatiotemporal control of gene expression.

43 tal and environmental cues depend on precise spatiotemporal control of gene transcription.

44 ign of future microfluidic devices, allowing spatiotemporal control of microdroplet generation withou

45 Our study links spatiotemporal control of mitochondrial PMF to cellular

46 is known about the mechanisms underlying the spatiotemporal control of self-renewal during skeletal m

47 the circadian system with aging through the spatiotemporal control of the molecular clock.

48 ane-bound and membraneless organelles ensure spatiotemporal control of various cellular functions.

49 Photo-mediation offers unparalleled spatiotemporal control over controlled radical polymeriz

50 ctivation of a degrader to achieve exquisite spatiotemporal control over protein stability in cells h

51 ated initiation and propagation steps enable spatiotemporal control over the polymerization.

52 tumour treatment with flexible, facile, and spatiotemporal control.

53 maintenance of genomic stability depends on spatiotemporal coordination between the transcription an

54 facilitate an advanced understanding of the spatiotemporal coordination of signal transduction proce

55 fied regulatory mechanism, which can provide spatiotemporal coordination of WG differentiation with t

56 Spatial and spatiotemporal correlation of individual receptor subuni

57 cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans.

58 One promising tool for increasing the spatiotemporal coverage of OMP data sets is through the

59 The network interprets spatiotemporal cues about the progression of mitosis and

60 establish a simple mechanism for femtosecond spatiotemporal current control in designer nanosystems.

61 a network-based model, called Chronnet, for spatiotemporal data analysis.

62 The number of spatiotemporal data sets has increased rapidly in the la

63 We amassed a global, spatiotemporal dataset describing parasite prevalence ac

64 ork highlights the importance of using dense spatiotemporal datasets, and modeling frameworks that ac

65 This study quantitatively compares the spatiotemporal deposition patterns between different hyd

66 The spatiotemporal details underlying these protein dynamics

67 rajectory analysis tools to characterize the spatiotemporal development of the mouse neocortex, ident

68 infancy are lacking, we aimed to assess the spatiotemporal developmental features of "neural flexibi

69 the gradient of Erk activity and eliminated spatiotemporal differences in terminal gap gene expressi

70 each with sparser MB concentration, based on spatiotemporal differences in the flow dynamics (flow sp

71 face viscous stresses for sufficiently small spatiotemporal distances from the breakup point, and all

72 limate change-related abiotic factors on the spatiotemporal distribution and growth potential of Tric

73 Knowledge of spatiotemporal distribution and likelihood of (re)occurr

74 information can be assimilated into broader spatiotemporal distribution models to interpret the infl

75 on of signalling capacity, combined with the spatiotemporal distribution of developmental signals the

76 quantitatively characterize the fine-grained spatiotemporal distribution of inter-ictal epileptiform

77 aging (MSI) enables the visualization of the spatiotemporal distribution of molecules in biological s

78 However, the spatiotemporal distribution of particle radioactivity an

79 be possible without explicitly incorporating spatiotemporal distribution of predation risk.

80 essential to have an understanding of their spatiotemporal distributions.

81 environments with corresponding patterns of spatiotemporal divergence.

82 amic imaging during IA infusion captured the spatiotemporal dynamic of infiltration for each molecule

83 ly supported by strong evidence for balanced spatiotemporal dynamics observed in the cerebral cortex;

84 The spatiotemporal dynamics of denitrification in groundwate

85 The spatiotemporal dynamics of dysregulated pH across diseas

86 The spatiotemporal dynamics of excitatory neurotransmission

87 We assessed the spatiotemporal dynamics of forest resistance and resilie

88 lly, we find that retinoic acid controls the spatiotemporal dynamics of Hgf/Met signaling to coordina

89 Further, live imaging reveals that the spatiotemporal dynamics of leukemia cells are critically

90 Consequently, we were able to study the spatiotemporal dynamics of N(2) production due to denitr

91 In this study, spatiotemporal dynamics of onion yellows (OY) phytoplasm

92 port novel, to our knowledge, aspects of the spatiotemporal dynamics of RBC suspensions flowing throu

93 iption opioids from 2010-2017 to analyze the spatiotemporal dynamics of the opioid overdose epidemic.

94 This allowed us to isolate the spatiotemporal dynamics of visual word recognition acros

95 al colonization in single animals, revealing spatiotemporal dynamics undetectable by previously avail

96 stories can also yield different patterns of spatiotemporal dynamics.

97 lied a genomic approach to investigate their spatiotemporal emergence by sequencing the genomes of 10

98 le mechanisms that act together for accurate spatiotemporal emergence of the new organ.

99 notype trends indicates complex responses to spatiotemporal environmental gradients potentially due t

100 summer is modified by previously experienced spatiotemporal environmental heterogeneity across 14 rep

101 Spatiotemporal epidemic simulations demonstrated that co

102 Here we tracked spatiotemporal ERK MAPK dynamics in human epidermal stem

103 protein is an important new regulator of the spatiotemporal events in HR.

104 In this work, we sought to dissect the spatiotemporal events involved in the biogenesis of the

105 d compare quantitative predictions about the spatiotemporal evolution of MTOC position and MT cytoske

106 These findings reveal the spatiotemporal evolution of vascular remodeling after st

107 for the genesis, selection, and stability of spatiotemporal excitation patterns.

108 we observed negligible correlations between spatiotemporal expression and transcription kinetics for

109 We analyzed the spatiotemporal expression of a selected set of pea aphid

110 lly overlap in the sequestration of Smo, the spatiotemporal expression of Boc and Gas1 may determine

111 hogen signaling contributes to the patterned spatiotemporal expression of genes during development.

112 homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes.

113 ese findings establish how a precisely timed spatiotemporal expression of Phf21b creates an epigeneti

114 abidopsis thaliana roots, auxin controls the spatiotemporal expression of the plasmodesmal regulator

115 se three R2R3-MYB genes exhibits a different spatiotemporal expression pattern.

116 onstrate that SynGAP isoforms exhibit unique spatiotemporal expression patterns and play distinct rol

117 early demonstrated 50 ST genes had different spatiotemporal expression patterns in leaf tissues, 10 S

118 We then identified the spatiotemporal expression patterns of these genes at key

119 ding to BMP and found that they have diverse spatiotemporal expression patterns.

120 Although most effectors show conserved spatiotemporal expression profiles and likely function,

121 and gridded dataset characterizing different spatiotemporal facets of soil salinity and sodicity vari

122 r, this mechanism can explain other puzzling spatiotemporal features of drug-resistance epidemiology

123 within individual AZs, which determines the spatiotemporal features of MVR events and is controlled,

124 everse, entering the medium as a complicated spatiotemporal field and arriving after propagation as a

125 eport at single cell resolution the evolving spatiotemporal fields of cell migration speeds, cell sha

126 Such waves are special "pre-scattered" spatiotemporal fields, which propagate through a complex

127 Here, we investigated the spatiotemporal fluctuations of wetlandscape connectivity

128 le/DNAzyme reaction cascade that generates a spatiotemporal fluorescence read-out depending on the dr

129 agation as a desired target field, such as a spatiotemporal focus.

130 Here, we evaluated the spatiotemporal formation of bone and fibrous tissues aft

131 l functions; however, how cells regulate the spatiotemporal formation of G4 structures in the genome

132 base excision repair (BER) pathway drive the spatiotemporal formation of G4 structures in the genome.

133 lls divide naturalistic movies into adjacent spatiotemporal frequency domains with equal stimulus pow

134 The relationship between spatiotemporal gait asymmetry and walking energetics is

135 aradigm has been used to study adaptation of spatiotemporal gait parameters in relation to energetics

136 Mean and variability of spatiotemporal gait parameters were calculated during th

137 We utilized observational surveys and spatiotemporal Gaussian process regression modeling in t

138 Here, using spatiotemporal gene ablation in murine hair follicles, w

139 rafish to elucidate the mechanisms governing spatiotemporal gene expression during heart regeneration

140 Chromatin regulates spatiotemporal gene expression during neurodevelopment,

141 Ybx1 fine-tunes PRC2 activities to regulate spatiotemporal gene expression in embryonic neural devel

142 Chromatin modifiers affect spatiotemporal gene expression programs that underlie or

143 Spatiotemporal gene regulation is often driven by RNA-bi

144 e leading to thorax closure corresponds with spatiotemporal gradients of two heterophilic atypical ca

145 s, it is critical that models encompass both spatiotemporal heterogeneity in transmission and movemen

146 oclimatic forcing, we demonstrate the strong spatiotemporal heterogeneity of hydrologic transport dyn

147 ing to the diversity of cancer types and the spatiotemporal heterogeneity of tumour signals, high-res

148 environments are characterized by pronounced spatiotemporal heterogeneity, which can present sampling

149 hese slow and fast activities exhibit a high spatiotemporal heterogeneity.

150 This distribution showed a high spatiotemporal heterogeneity.

151 cal nervous systems are promising to process spatiotemporal information and can provide highly time-

152 ecause of the lack of suitable tools, little spatiotemporal information on protease activities on NET

153 ge-scale EGT arrays, and EGT application for spatiotemporal information processing in an SNN are yet

154 ecular motors because one can direct precise spatiotemporal inputs while conducting reactions in the

155 le and low-cost form factors, enabling rapid spatiotemporal inspection by digital cameras or the nake

156 embly applications by designing more complex spatiotemporal interactions using mobile robots.

157 rophy in a mouse model, we characterized the spatiotemporal interplay among cell types, and tested po

158 ected by many factors that create a variable spatiotemporal landscape of their availability both at t

159 Here, we studied the spatiotemporal localization dynamics of the key regulato

160 d serve as a facile PET nanotracer to survey spatiotemporal macrophage dynamics during various physio

161 The varying degrees of spatiotemporal manipulation afforded by such techniques

162 tegrate other cells and cytokines in a tuned spatiotemporal manner for personalized regenerative medi

163 d cluster of differentiation 36 (CD36), in a spatiotemporal manner in single cells.

164 s coordinate hypoxic cellular responses in a spatiotemporal manner.

165 ing from the motor cortex and expanding in a spatiotemporal manner.

166 Together, these data provide a spatiotemporal map for laminae-specific molecules and su

167 It has also been demonstrated for disease spatiotemporal mapping and pathogen tracking by wireless

168 ive pluripotency progression and enabled the spatiotemporal mapping of differentiating ESCs to their

169 Spatiotemporal mapping of the lateral hemispheric surfac

170 2+) -dependent calpain proteases, generating spatiotemporal maps of the entire retina in the cpfl1 mo

171 this paper, we formulate an individual-level spatiotemporal mechanistic framework to integrate indivi

172 NAD(P)H and FAD to nondestructively resolve spatiotemporal metabolic heterogeneity of individual mac

173 als from a chemokine and cAMP to specify the spatiotemporal mobilization of Ca(2+) to drive cell migr

174 d simulated atmospheric chemistry, we used a spatiotemporal model to estimate 3-year average PM2.5 ex

175 ectives of this study were to: (a) develop a spatiotemporal model to evaluate if drought severity exp

176 4)-based optical isolator is demonstrated by spatiotemporal modulation, with over 17 dB isolation ach

177 ofilms grown on agar substrates in which the spatiotemporal morphological patterns were altered by va

178 one hand and the scale-free organization of spatiotemporal network dynamics of spontaneous activity

179 e device might facilitate the probing of the spatiotemporal neural codes underlying behaviour.

180 w their nonequilibrium properties define the spatiotemporal organization of the cell.

181 key mechanisms used by cells to control the spatiotemporal organization of their many components is

182 ant gaps exist in our understanding of their spatiotemporal organization, limiting our ability to unc

183 o quantify the evolutionary characteristics, spatiotemporal origins, and multi-host transmission dyna

184 amera arrays have informed inferences on the spatiotemporal outcomes of predator-prey interactions, t

185 sum, our microfluidic platform can quantify spatiotemporal parameters influencing diffusion-mediated

186 Variability in the spatiotemporal parameters of stimulation employed to dat

187 Results revealed spatiotemporal parameters were altered between condition

188 a wave-like manner, resulting in a distinct spatiotemporal pattern of cell death(7,8).

189 iability sources.In the rd1 and rd10 models, spatiotemporal pattern of increased calpain activity mat

190 Each motif captured a unique spatiotemporal pattern of neural activity across the cor

191 n to Up state, it significantly affected the spatiotemporal pattern of the slow waves and maximized m

192 ressing how motor training develops accurate spatiotemporal patterns in behavior and influences the p

193 er understanding of possible drivers for the spatiotemporal patterns observed at seizure onset and ma

194 ics, and it accurately predicts two distinct spatiotemporal patterns observed in the experiments-the

195 interactions may not always result in strong spatiotemporal patterns of avoidance.

196 Furthermore, EGF induced three distinct spatiotemporal patterns of cysteine oxidation in functio

197 In this work, the spatiotemporal patterns of dynamical actin assembly acco

198 n networks disorder characterized by altered spatiotemporal patterns of functional connectivity (FC),

199 etween sequentially active neurons shape the spatiotemporal patterns of HVC premotor neuron activity.

200 ty of clinically and experimentally observed spatiotemporal patterns of seizure onset and even less s

201 s behind the RS-functional connectivity (FC) spatiotemporal patterns, we systematically manipulated t

202 to several hours of experience with unusual spatiotemporal patterns.

203 ed to be uncoupled as they occur in separate spatiotemporal patterns.

204 ously identified and never before identified spatiotemporal patterns.

205 Here, we quantified spatiotemporal pharmaceutical exposure concentrations an

206 ly organized colonies in which cells undergo spatiotemporal phenotypic differentiation in response to

207 d compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of

208 n important resource for exploring nonlinear spatiotemporal population dynamics.

209 imparted by chemokines that coordinate their spatiotemporal positioning.

210 vascular structure and blood flow with high spatiotemporal precision after photothrombotic infarcts

211 ty and orthogonality of intrabodies with the spatiotemporal precision of optogenetics.

212 bitors cannot be experimentally applied with spatiotemporal precision suiting the length and time sca

213 manipulation of cellular processes with high spatiotemporal precision.

214 d model to explain HD presence and evaluated spatiotemporal predictors across the region.

215 ral membrane-centric outlook underscores the spatiotemporal principles of membrane and signaling lipi

216 gs generated for the first time a continuous spatiotemporal profile of local field potentials (LFP) a

217 lease (MVR) occurs at most synapses, but its spatiotemporal properties are unknown.

218 Here, we unveil the spatiotemporal properties of physiological signals that

219 icrotubules act as cargo carriers to control spatiotemporal protein distribution, which in turn contr

220 Spatiotemporal reconstructions exhibited similar spatial

221 ation processing that allows transmission of spatiotemporal redox commands which are then decoded by

222 neural activity in a largely uncharacterized spatiotemporal regime.

223 Interestingly, AIM2 was subjected to spatiotemporal regulation by RGFP966.

224 essed or mutated protein receptors for which spatiotemporal regulation differs between and within can

225 However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not co

226 biosensors are powerful tools to illuminate spatiotemporal regulation of cell signaling in living ce

227 ay cells meet the biological requirement for spatiotemporal regulation of cellular components and rea

228 es will enable scientists to study uncoupled spatiotemporal regulation of different genetic alteratio

229 ions are emerging as critical players in the spatiotemporal regulation of gene expression.

230 We investigated the spatiotemporal regulation of LAG-1/CSL expression in Cae

231 We also discuss accumulating evidence for spatiotemporal regulation of microglial activation in th

232 During mitosis, spatiotemporal regulation of phosphorylation at the kine

233 y circuit and has broad implications for the spatiotemporal regulation of signaling networks.

234 d by high AMF turnover rates with a positive spatiotemporal relationship for AMF beta-diversity.

235 with an emphasis on advances that expand the spatiotemporal resolution and extent of mapping and mani

236 ng simultaneous volumetric imaging with high spatiotemporal resolution and high dynamic range force c

237 on of electrical activity with unprecedented spatiotemporal resolution and parallelism.

238 However, established methods with high spatiotemporal resolution are limited by the potential f

239 This visualization at high spatiotemporal resolution enabled us to estimate an aver

240 bly simulator (NERDSS), which addresses this spatiotemporal resolution gap.

241 ach to the mapping of brain activity at high spatiotemporal resolution in awake subjects within the w

242 n of mitochondrial Ca(2+) dynamics with high spatiotemporal resolution in parallel with the use of gr

243 Here, using high spatiotemporal resolution light-sheet microscopy (~1.4 v

244 Using high spatiotemporal resolution live cell imaging, we found th

245 teractions at an air-liquid interface with a spatiotemporal resolution unattainable in animal models

246 uorescence-based approach that balances high spatiotemporal resolution with extraordinarily large fie

247 Existing tools offer high spatiotemporal resolution, reversibility and repeatabili

248 e range of nanoscale materials with ultimate spatiotemporal resolution.

249 eter biological channels or cavities at high spatiotemporal resolution.

250 ological functions at the genomic level with spatiotemporal resolution.

251 capable of in-operando conditions with high spatiotemporal resolutions limits the understanding of m

252 ailable climate data and the climate at fine spatiotemporal resolutions relevant to most organisms an

253 y, overall we highlight a notable absence of spatiotemporal response by female elk to the risk of pre

254 Analysis of the spatiotemporal response of the LC supports our proposal

255 hallenges in a comprehensive analysis of the spatiotemporal responses of adult female elk (Cervus ela

256 This indicates that the observed spatiotemporal richness and community variability of AMF

257 ting variability that is caused by irregular spatiotemporal sampling conditions.

258 However, aliasing caused by irregular spatiotemporal sampling of emissions is shown to signifi

259 -requisite for codependency - changes across spatiotemporal scales and taxonomic resolution for both

260 avoid or escape predators occur at different spatiotemporal scales and that they are supported by dif

261 stent measurements of predation risk, biased spatiotemporal scales at which responses are measured an

262 s.Dual Perspectives Companion Paper: Diverse Spatiotemporal Scales of Cholinergic Signaling in the Ne

263 ey habitat use and behavior over much larger spatiotemporal scales than previously documented in any

264 mited investigation of marine taxa at larger spatiotemporal scales, macroecologists and paleobiologis

265 distribution of populations, but, on larger spatiotemporal scales, non-competitive factors may have

266 niche space and population decline at broad spatiotemporal scales, while guiding management actions

267 In this review, we will discuss how various spatiotemporal scenarios of antigen access into secondar

268 a high-precision diet study by expanding its spatiotemporal scope of inference and recommend this int

269 nthetic and biological, demonstrates complex spatiotemporal self-organization and the emergence of co

270 administration effect was detected with high spatiotemporal sensitivity on contracting cardiomyocytes

271 receptor therapeutic development, including spatiotemporal signaling and the kinetic context of bias

272 We infer a spatiotemporal signaling network of endoderm-mesoderm in

273 ited to address the limitations posed by the spatiotemporal sparseness of the observational record.

274 ecent studies have revealed a high degree of spatiotemporal specificity in cholinergic signaling.

275 Forecasting the spatiotemporal spread of infectious diseases during an o

276 We investigate the spatiotemporal spread of LP through an analysis of 14 wa

277 nterventions, to assess potential drivers of spatiotemporal spread, and to support contact tracing ef

278 sented sensor technology not only tracks the spatiotemporal state of cells under test but also measur

279 ent genomes with archaeometric datasets in a spatiotemporal statistical framework, which we foresee w

280 In Fmr1(-/y) circuits, the spatiotemporal structure of Up-states was less reproduci

281 critical state characterized by a scale-free spatiotemporal structure.

282 ity require destructive processing, limiting spatiotemporal studies of function within the live, inta

283 se late Ca(2+) sparks and their (subsequent) spatiotemporal summation into Ca(2+) ripples/waves.

284 transmission electron microscopy, we map the spatiotemporal surface profiles of supracrystals, which

285 We used methylation assays and spatiotemporal surveys of MeHg concentrations, during th

286 ankle dorsiflexion contractions aiming at a spatiotemporal target.

287 This study provides insights into how a spatiotemporal transcription factor coordinates heteroch

288 of this study is to further characterize the spatiotemporal transcriptional regulation of B. burgdorf

289 in the semiconductor, without an equivalent spatiotemporal transfer of charge.

290 Understanding of spatiotemporal transmission of infectious diseases has i

291 This is the first study to analyze spatiotemporal trends in particle radioactivity using me

292 e Upper Peninsula of Michigan, USA to relate spatiotemporal variability in wolf density to underlying

293 thod can also be applied for quantifying the spatiotemporal variability of other dynamic soil propert

294 mpact of such heterogeneity, we investigated spatiotemporal variation in AMF diversity on a plot scal

295 Relationships were detected between spatiotemporal variation in AMF OTU richness and plant s

296 ividual-based model to examine the effect of spatiotemporal variation in host home range size on the

297 ion nesting in Cabo Verde, we determined the spatiotemporal variation of Ozobranchus margoi, a sangui

298 red by a lack of knowledge about spatial and spatiotemporal variations in regional background UFPs.

299 also useful for downstream analyses, such as spatiotemporal visualization of viral dynamics.

300 Ca2+ dynamics inside the excitable cells are spatiotemporal while the membrane voltage is a global si