ライフサイエンスコーパス: species specificity

1 interface, defining the basis of lipid IV(A) species specificity.

2 oxA and BoxB, the latter of which determines species specificity.

3 if so to investigate its tissue tropism and species specificity.

4 synergistically result in the appearance of species specificity.

5 ally, suggesting fhaS may contribute to host-species specificity.

6 mechanistic link between incompatibility and species specificity.

7 Three near-neighbor genomes are critical for species specificity.

8 t position 128 was a critical determinant of species specificity.

9 e both sexual and asexual phases with strict species specificity.

10 h residues 99 and 146 also contribute to the species specificity.

11 ory elements that modulate cell, tissue, and species specificity.

12 ution, lentiviruses exhibit a high degree of species specificity.

13 ry of anti-adhesives targeted for strain and species specificity.

14 the rat, human, and mouse genes, suggesting species specificity.

15 ial cells and in vivo in the rat, showing no species specificity.

16 te interactions during fertilization exhibit species specificity.

17 ons at fertilization is relative or absolute species specificity.

18 es, the vaccinia IFN-gamma R has novel broad species specificity.

19 spaced domains in human MUC2, which defines species specificity.

20 es on host glycans is a major determinant of species specificity.

21 reclinical animal models due to HBV's strict species specificity.

22 t might be targeted by antibodies with cross-species specificity.

23 pair stabilization in mediating conjugation species specificity.

24 arly embryogenesis with remarkable stage and species specificity.

25 oters from Aedes mosquitoes exhibited strong species specificity.

26 luenza B virus is unique in that it exhibits species specificity.

27 human IL-6R, indicating that p28 exhibits no species specificity.

28 nts that contribute to inhibitor binding and species specificity.

29 thereby influencing viral pathogenicity and species specificity.

30 tain high infectivity, strain properties and species specificity.

31 uire cultured human cells and tissues due to species specificity.

32 ial advantages in terms of effectiveness and species specificity.

33 the MD-2 residues that determine lipid IV(A) species specificity.

34 ing these stretches as major determinants of species specificity.

35 dicating a role for the initiator element in species-specificity.

36 tive and Gram-positive bacteria and displays species-specificity.

37 wal times; these effects exhibited drug- and species-specificity.

38 n humans and vice versa, reflecting dramatic species-specificity.

39 , including disparate cellular receptors and species specificities.

40 smRandom-seq showed a high species specificity (99%), a minor doublet rate (1.6%),

41 al ribosome entry site (IRES) in determining species specificity, a recombinant poliovirus (P1/HRV2)

42 H-A3F showed no change in its species specificity against HIV-1 or SIVagm Vif when a n

43 ne, murine, or human OVGP1, conferred the ZP species-specificity, allowing only the penetration of th

44 prion protein itself is responsible for its species specificity, although questions remain about whe

45 nique BoxB hexamer motifs within parS define species specificities among previously described family

46 Our results reveal a higher degree of species specificity among TCF proteins for coactivator i

47 The results show species specificity among the I-2 family within the cont

48 tis B virus (HBV) is characterized by a high species specificity and a distinct liver tropism.

49 Interestingly, two of the compounds exhibit species specificity and are inactive toward murine perit

50 We also assessed the species specificity and biochemical characteristics of m

51 acellular matrix contains proteins mediating species specificity and components needed for efficient

52 This is mainly due to species specificity and limited homology among cytomegal

53 , there is a direct mechanistic link between species specificity and partition-mediated incompatibili

54 into the origin and evolution of AiV and the species specificity and pathogenesis of kobuviruses.

55 This elegant solution ensures species specificity and promptness of imitation.

56 We used species specificity and re-localization strategies to or

57 Strong species specificity and similar tropisms suggest mouse c

58 The viral determinants for the pronounced species specificity and the high efficacy to address hep

59 However, species specificity and the lack of codominance make RAP

60 Noroviruses display tight species specificity and there is no evidence supporting

61 tinomycetemcomitans adhesin Aae demonstrated species specificity and tissue tropism to buccal epithel

62 as long been recognized for its role in host species specificity and transmission, membrane fusion an

63 . astaci, and (2) whether there are crayfish species-specificities and/or geographical restrictions f

64 Our results revealed both high species-specificity and elevated rates of evolution in p

65 To investigate species-specificity and potential for cross species tran

66 ays suggested a positive correlation between species-specificity and taxonomic distance.

67 scribed spacer region sequencing, by testing species specificity, and by assessing its capacity to id

68 ew insights into astrovirus host cell entry, species specificity, and evolution.

69 termines their level of replication fitness, species specificity, and pathogenic potential.

70 WNV has broad species specificity, and replicates efficiently in many

71 he rate of recombination exhibits remarkable species specificity, and, within a species, recombinatio

72 s showed widely varying neurosteroid levels, species specificity appeared to exist.

73 Our results suggest this species-specificity arises in part through host-microbe

74 tes and CD47-displaying CHO cells affirm the species specificity as well as the importance of the new

75 FITZAP-lysin interactions exhibit a similar species-specificity as lysin-VERL interactions.

76 Both LAMP tests possess remarkable species-specificity as they did not amplify non-target D

77 s rationalization of the molecular basis for species specificity based on the use of spatially contig

78 BoxB sequence changes that switch species specificity between P1, P7, and pMT1 species swi

79 cess for this system may depend on achieving species specificity between the related human host and t

80 IpaH7.8 contributes to species specificity by ubiquitinating human, but not mou

81 of the primer pairs was further assessed for species specificity by using a panel of 102 isolates obt

82 Here we investigate the nature of this species-specificity by examining whether chimeric Escher

83 Species-specificity checking against 15 important meat a

84 To determine the reason for this species specificity, chimeras were constructed linking t

85 ementing Pichia angusta ortholog showed that species specificity could not be explained by the presen

86 Here, we examine the species specificity differences between Yersinia pestis

87 The second set of epitopes as well as the species specificity domain cluster around the loop 3-hel

88 domain within human HVCN1 that drives LukAB species specificity, enabling the generation of humanize

89 erstood, predominantly because of the strict species specificity exhibited by HCMV.

90 e structures support the hypothesis that the species specificity exhibited by the A-site cleft inhibi

91 de one explanation for this restriction: the species specificity exhibited by the NS1 protein of infl

92 the I domain, a property that determines the species specificity exhibited by this toxin.

93 ate that this site is involved in conferring species specificity for binding GH.

94 y factor and the primary determinant of host species specificity for group A streptococcal infection.

95 Previous studies have shown species specificity for metabolites involved in plant ad

96 LTGO-33 displayed species specificity for primate Na(V)1.8 over dog and ro

97 Here, we defined the mechanism of species specificity for T. gondii sexual development and

98 ls was lower than to human cells, suggesting species-specificity for adherence.

99 receptor that may be involved in determining species specificity, i.e. the transmembrane VI, the thir

100 allmark of fertilization is a high degree of species specificity, implying gamete-specific recognitio

101 This also indicated species specificity in biomineralization depending on nu

102 ids, Mormyrids, and Pomancentrids--for which species specificity in both signal production and differ

103 and emotional behavior, in discrimination of species specificity in chemosignals.

104 Unexpectedly, we found no evidence of species specificity in cross-seeding polymerization assa

105 ing the protein-coding region, suggestive of species specificity in evolution and function of this oo

106 This difference highlights the importance of species specificity in IL-1alpha transport and may partl

107 These viruses show marked species specificity in receptor utilization, as HCV-229E

108 mouse and rat V1R gene clusters to test for species specificity in rodent pheromone systems.

109 te to differences in outcomes, and we report species specificity in the impact of CR in terms of opti

110 amino acids (A288L and T330R) that regulate species specificity in the mouse.

111 ovides insight into the structural basis for species specificity in the tissue factor-factor VIIa int

112 t networks of interactions might account for species specificity in these low affinity and high avidi

113 on correlates with, and may account for, the species specificity in transmission of transmissible spo

114 well as the critical importance of defining species specificity in visual signaling.

115 (RCMV) and murine CMV (MCMV) exhibit extreme species specificity in vivo, they differ in their abilit

116 TFIIB plays an important role in determining species specificity in vivo.

117 adherence is supported by the observation of species-specificity in adhesion: microgametes of the hum

118 Lysins from seven California abalone exhibit species-specificity in binding to their egg receptor, an

119 Lysin, the 16-kDa protein, exhibits species-specificity in dissolving a hole in the egg vite

120 These interactions show strong species specificity, indicating that conserved residues

121 analysis of the element, we demonstrate that species specificity is attributable to just three varian

122 We demonstrate that the species specificity is caused by a single amino acid dif

123 To investigate how this species specificity is conformationally encoded, we used

124 Here, the cellular basis for this species specificity is demonstrated to result from diffe

125 T from human cells, which indicates that the species specificity is determined by differences in the

126 Molecular modeling suggests that species specificity is determined by the capacity to for

127 This mechanism of species specificity is the first defined for a parasite

128 t have the ClpB middle domain, implying that species-specificity is due to an interaction between Dna

129 Nacre species-specificity is interpreted as a result of adapta

130 rimental model systems related to virus-host species specificity, limited identification of in vivo l

131 This species specificity mapped primarily to the cytoplasmic,

132 el, suggesting that previously inferred host species-specificity may have resulted from poorly sampli

133 erpretation of electron density, rather than species specificity, may be responsible for many of the

134 s a leading cause of myocarditis, but due to species specificity, models of infection are lacking, an

135 from demerits such as toxicity of exposure, species specificity, noxious gas emission, environment-d

136 Species specificity occurred but did not influence the g

137 The differential host species specificities of Bordetella pertussis, B. parape

138 TCPs have increased our understanding of the species specificities of HBV and HDV, and could lead to

139 ng the primary components that determine the species specificities of influenza A viruses.

140 these conditions, the strain properties and species specificities of the resulting cervid prions wer

141 generation of the novel receptor binding and species specificities of these bacteriocins has been dri

142 EGF receptor (EGFR) ligand and species specificities of Y-142 were tested.

143 y normal mouse serum, highlighting the human species specificity of A. baumannii serum resistance.

144 of P. gingivalis to S. gordonii and that the species specificity of adherence arises from its interac

145 s directly, the mechanisms involved, and the species specificity of algal-coral interactions remain u

146 These results support species specificity of amino acid racemization dating.

147 However, the species specificity of B(c) has precluded testing of inh

148 However, the species specificity of beta(c) has precluded testing of

149 The species specificity of binding of human fH adds another

150 The species specificity of Bordetella gene targets and their

151 is used to carry the system, overcoming the species specificity of conventional Epstein-Barr virus v

152 wild-type CRP activated mouse C3, indicating species specificity of CRP-C1q interaction.

153 ikely one of the factors that contributes to species specificity of cytomegalovirus replication.

154 Due to the species specificity of cytomegaloviruses, murine cytomeg

155 moved from an editing site, can transfer the species specificity of editing between RNA substrates.

156 that polymorphisms in another can change the species specificity of erythrocyte binding.

157 We investigated the species specificity of fH binding and the effect of huma

158 The species specificity of FH binding to BBA68 was also test

159 rmlings of the same species, indicating that species specificity of germling fusion has evolved not o

160 e findings provide further insights into the species specificity of gonococcal infections and proof-o

161 HCMV) pathogenesis during pregnancy, but the species specificity of HCMV and the limited availability

162 However, because of the species specificity of herpesviruses, only a limited num

163 Because of the species specificity of HPVs, study of their natural tran

164 ord and suggest that the IRES determines the species specificity of HRV2 infection.

165 hogenesis of adenovirus myocarditis, and the species specificity of human adenoviruses has limited th

166 hymena thermophila telomerase as well as the species specificity of human and mouse telomerase for th

167 The strict species specificity of Human Cytomegalovirus (HCMV) has

168 tural host has been limited by the exquisite species specificity of human gammaherpesviruses and the

169 panzees with human IFN-alpha were not due to species specificity of IFN-alpha.

170 ent species are critical determinants in the species specificity of infection.

171 Species specificity of influenza virus is determined by

172 e results indicate that there is significant species specificity of intrinsic complement regulatory p

173 ontains this conserved motif, explaining the species specificity of IpaH7.8.

174 oferrin will now facilitate the study of the species specificity of lactoferrin action in a mouse mod

175 eta(2)-integrins on leukocytes, and that the species specificity of Lkt-induced effects is resident i

176 hly similar to the S-component of LukED, the species specificity of LukPQ and LukED differs.

177 repetitive human genome and illustrates the species specificity of mechanisms that control it.

178 Our data suggest that the species specificity of MHV-68 RTA resides in the N-termi

179 rics model, provide an understanding for the species specificity of MK.

180 The receptor and species specificity of MV-uPAs was shown in human and mu

181 field isolates might thus contribute to the species specificity of MYXV and to the attenuation in th

182 However, the species specificity of non-human in-vivo models and the

183 Recent notable discoveries are the broad species specificity of orthopoxvirus interferon receptor

184 We have defined the genetic basis of the species specificity of OTai by evaluating the properties

185 s and HIV/SIV isolates reveal the host/virus species specificity of pDC sensing.

186 residues in BSG that are responsible for the species specificity of PfRH5 binding.

187 To explain these data, and the species specificity of PlyL, we propose that the C-termi

188 ograft nephropathy (PVAN) is hampered by the species specificity of Polyomaviridae family members.

189 Although mechanisms that control species specificity of prion transmission are poorly und

190 ers of its microbiota revealed the bacterial species specificity of selected host responses.

191 patients, we used T cell clones to probe the species specificity of the Ags recognized.

192 We characterized the species specificity of the antibody other investigators

193 ells but not in human cells, suggesting host species specificity of the antiviral effect.

194 nes, demonstrating the potential to tune the species specificity of the catalytic domain of an endoly

195 Restriction of viral DNA replication due to species specificity of the DNA polymerase, coupled with

196 The species specificity of the glmM PCR assay was demonstrat

197 ceptor* on differentiated hepatocytes, while species specificity of the HBV infection requires select

198 The species specificity of the interaction is controlled by

199 We took advantage of the species specificity of the interferon receptors by analy

200 anocortin receptors, indicating a remarkable species specificity of the MC1 receptor requirements.

201 human TFH cell differentiation, reflecting a species specificity of the miR-31 action.

202 ensin receptors, and structural elements for species specificity of the neurotensin receptors, and ma

203 Species specificity of the PCR amplicons was further dem

204 lymerase I transcription factors may lead to species specificity of the rDNA transcription machinery.

205 nosa, and Citrobacter freundii to ensure the species specificity of the selected aptamers.

206 Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TL

207 The molecular basis for species specificity of the two toxins in animal models i

208 As predicted, the species specificity of the two types proved identical.

209 By taking advantage of the species specificity of the type II pathway, we have used

210 ion of pathogen and host and often lead to a species specificity of the virus that can make interspec

211 The replicative capacity and species specificity of these BAC-derived MnatCMVs were a

212 ne hamster scrapie strain to investigate the species specificity of these conversion reactions.

213 However, the significance and species specificity of these proposed functions in vivo

214 developmental regulation and the tissue and species specificity of these variants and showed that th

215 the absence of leukocytes by exploiting the species specificity of this cytokine in a chimeric model

216 We provide explanations for the narrow species specificity of this drug class and demonstrate d

217 To identify the molecular basis for the species specificity of this interaction, hPg and mPg var

218 rface, suggesting a structural basis for the species specificity of this interaction.

219 ible region can either abolish or change the species specificity of this interaction.

220 tivation in vivo on the cell surface and the species specificity of this molecule remain to be fully

221 sodium chloride; however, the characteristic species specificity of this parasite suggested the exist

222 The species specificity of this property is unique among kno

223 al for H18N11 binding, may explain the broad species specificity of this virus.

224 eptor external domains are important for the species specificity of transferrin binding and imply tha

225 neumocystis carinii showed just the opposite species specificity of tRNA recognition.

226 a revealed that, in otherwise intact Pg, the species specificity of VEK-30 binding in these two cases

227 range restriction, which contributes to the species specificity of virus replication, and that human

228 ades a key aspect of innate immunity and the species specificity of Vpu using an anti-parallel helix-

229 ajor resistance genes contribute to the host species specificity of wheat stripe rust on barley and t

230 To investigate host species' specificity of mycobacterial virulence, growth

231 ow that the uL4 loop sequence determines the species-specificity of antibiotic action.

232 To investigate possible species-specificity of aryl hydrocarbon receptor (AhR)-m

233 , murine, or human sources in modulating the species-specificity of bovine and murine oocytes.

234 Species-specificity of HCV host factor usage for cell en

235 e Hsp104 and ClpB middle domains dictate the species-specificity of Hsp104 and ClpB for cell survival

236 This finding indicates an intrinsic species-specificity of ICP47 and suggests that no additi

237 prominent biological properties as the high species-specificity of infection, the effective in vitro

238 cross-species coaggregation, suggesting that species-specificity of prion transmission is controlled

239 Due to the species-specificity of renin activity, transgenic mice a

240 ue in this PCDH1 surface influences the host species-specificity of SNV glycoprotein-PCDH1 interactio

241 Finally, the species-specificity of the human language faculty is sup

242 The species-specificity of the PCR amplicons was further dem

243 osa, and Citrobacter freundii, to ensure the species-specificity of the selected aptamers.

244 d evolutionary rate is likely related to the species-specificity of the transcriptional regulation mo

245 Our findings highlight the species-specificity of these developmental events and pr

246 The species-specificity of this interaction may play a role

247 Understanding the rodent/human species-specificity of urokinase inhibitors is therefore

248 ns, however, the pathogen exhibited no clear species-specificity or geographical patterns.

249 one ParB residue and one BoxB base can alter species specificity, plasmids may use such simple change

250 nal amino acid residues of alpha ENaC confer species specificity regarding ENaC inhibition by activat

251 signals that appear to cross germ layer and species specificities should prove valuable in understan

252 of bacterial ClpB, and vice versa, switches species specificity so that our chimeras now cooperate w

253 This reciprocal switch of species specificity strongly supports the notion that co

254 The absence of species specificity suggested that the conserved lipid A

255 n microarray, to understand the mechanism of species-specificity switch better.

256 fferent HAs may be important determinants in species-specificity switch.

257 ar the N terminus; this antibody has broader species specificity than the other well-characterized al

258 ntial applications is their high potency and species specificity that enables a single pathogenic spe

259 IC(50) value in the low micromolar range, a species-specificity that resulted in more efficacious in

260 have demonstrated that CTE function displays species specificity, that is, the CTE functions in human

261 Individual par systems can show distinct species specificities; the proteins from one type cannot

262 We took advantage of this species specificity to gain further insight into the mec

263 action of rapidly evolving molecules imparts species specificity to sperm-egg recognition in marine i

264 ed disruption of Zan that zonadhesin confers species specificity to sperm-ZP adhesion.

265 fy a small motif on rodent TfR1 that conveys species specificity to the entry of viruses into cells.

266 We mapped the region of FtsK implicated in species specificity to the extreme 140-amino-acid C-term

267 posttranslational modification, that confers species specificity to these two RecQ-like proteins.

268 duced in embryonated eggs similarly provided species specificity toward chicken sera.

269 ouse TERT backbone is sufficient to bias the species specificity toward human TPP1.

270 ic PCR amplification protocol with a broader species specificity using newly designed primers targeti

271 nkey adulteration in cooked sausages and its species specificity was confirmed bioinformatically in t

272 unosorbent Assay (ELISA) with improved broad species specificity was developed for the detection of s

273 To understand the basis of species specificity, we investigated the structure of an

274 Polyadenylation site clusters also exhibit species specificity, while plants ones generally show hi

275 companied by the corresponding switch in the species specificity with which the enzyme physically ass

276 Stripe rust exhibits host species specificity, with lineages that have adapted to