ライフサイエンスコーパス: specific

1 tiple studies and many appear highly context-specific.

2 Age-specific 10-year cumulative risk curves were used to dra

3 and simple and provided sensitive (99%) and specific (93%) detection of antibodies to all FMDV strai

4 it such graded changes without bursting near specific actions.

5 ulators of SIRT6 activity, however, not many specific activators have been reported.

6 eLa cells, where it showed a markedly higher specific activity compared with PLD4.

7 This cue-specific activity was independent of motor-related activ

8 synthesized in high radiochemical yield and specific activity.

9 ubling time, administered antibody, antibody specific-activity, and antigen-site density most impacte

10 ate the nanolenses, can mitigate against non-specific, adventitious nanoparticle binding, without the

11 chromatin differences may contribute to sex-specific ageing in flies.

12 to related synaptic transmission phenotypes, specific alterations in spontaneous neurotransmitter rel

13 pre-existing paranoia could be accounted by specific alterations to cognitive parameters characteris

14 important step towards enabling application-specific analog computing platforms to solve computation

15 However, allergen-specific analyses suggested increased risks of sensitiza

16 A strand-specific analysis of the data allowed pinpointing CodY-b

17 To this aim, we generated Langerin-specific and CD11c-specific knockout ((-/-)) mice lackin

18 structure uncovers an unexpected, eukaryotic specific and dynamic fidelity checkpoint implemented by

19 Consequently, multiple Na(V)1.7-specific and Na(V)1.8-specific blockers have undergone c

20 nomagnetic methodology was developed for the specific and ultrasensitive analysis of bacteria at thei

21 of diverse, functionally specialized, lamina-specific, and topographically ordered retinal ganglion c

22 18 non-HLA antigens synergize with HLA donor-specific antibodies and significantly increase the odds

23 Passively acquired maternal GBS-specific antibodies protect newborns from early-onset di

24 entify a combination of antigen- and epitope-specific antibodies that using 3- to 15-month or 2- to 3

25 anti-HLA-total IgG, IgG3 and IgG4, and donor-specific antibody by Luminex assay.

26 cific T cell responses correlated with spike-specific antibody responses.

27 ood and Drug Administration) is the prostate specific antigen (PSA) that is detected by conventional

28 Some ISGs have specific antiviral activity, whereas others regulate the

29 veloped and extensively characterized a head-specific approach to TBI in Drosophila, a powerful genet

30 rian cancer and were adjusted for the family-specific ascertainment schemes.

31 lopment of clinical AD; especially, the time-specific associations were notable: t-tau 8 to 16 years,

32 d Vaccinia virus Ankara vector to induce HBV-specific B- and T-cell responses.

33 egrity, can increase bacterial diversity and specific bacterial taxa in wine, with potential conseque

34 To detect any NR2B-specific binding of radioligand in brain, various preblo

35 Modeling studies unveil the specific binding sites for acetylene capture as well as

36 biochemical circuit cascade, which probes a specific biomolecular input, transform the input into a

37 tly, multiple Na(V)1.7-specific and Na(V)1.8-specific blockers have undergone clinical trials, with o

38 t bacterial molecules are likely exerting on specific brain cells.

39 ginosa and stress the need for P. aeruginosa-specific breakpoints.

40 These findings indicate that Sarm1 and/or specific calpain inhibitors could be developed to preven

41 for Pan-Cancer and reach an average 94% for specific cancers.

42 sing on GGGGCC-transcription have identified specific, canonical complexes that may promote RNAPII-tr

43 ith this carbon aerogel exhibit a remarkable specific capacity of 648 mAh g(-1) at a current density

44 id tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompet

45 e categories: (A) factors that relate to the specific case and analysis, which include the data, refe

46 riched from post-ATI plasma using macrophage-specific (CD14) but not CD4+ T cell-specific (CD3) antib

47 crophage-specific (CD14) but not CD4+ T cell-specific (CD3) antibodies, suggesting that M-tropic viru

48 Resting CMV-specific CD8 T cells were terminally differentiated and

49 The HLA-B*57:01-restricted, HIV epitope-specific CD8 T-cell responses showed beneficial function

50 ver, the role of cDC1s in expansion of tumor-specific CD8(+) T cells remains unclear.

51 e TCRalphabeta repertoire diversity of virus-specific CD8(+) T cells.

52 ction can lead to insights on the roles that specific cell types play during norovirus pathogenesis.

53 virions of ZIKV when they are released from specific cell types, and enhances virus attachment and e

54 To focus on specific cell types, the current paradigm is to physical

55 whose presence in blood is likely linked to specific cell-level pathologic processes.

56 own that sodium channels cluster together in specific cellular subdomains.

57 eral approach to engender endogenous patient-specific cellular therapy, without the need for a priori

58 reate a cohort of virtual patients with some specific characteristics, resembling the recruitment pro

59 that octopus arms use a family of cephalopod-specific chemotactile receptors (CRs) to detect poorly s

60 This suggests that sex-specific chromatin differences may contribute to sex-spe

61 ory effects per variant on several cell type-specific chromatin features.

62 Thus, our data characterize lineage-specific chromatin reconfiguration and a unique chromati

63 erials using oligonucleotide-based haplotype-specific chromosome painting.

64 CE STATEMENT This study in rats shows that a specific circuit in the brain [i.e., neurons that projec

65 A specific class of deep learning-based methods allows for

66 rts are being made worldwide to identify the specific clinical characteristics of infected critically

67 s have been limited to individual, specialty-specific clinics.

68 ed cells in mathematically predictable ways; specific combinations can even actively misdirect them.

69 define the structures of two unique species-specific components (Cag3 and CagM) and show that Cag3 i

70 t form the core of a dense network of highly specific connections between this region and other highe

71 tified left V3/V3A as the area with the most specific connectivity to migraine coordinates compared t

72 Model-based decisions use predictions of the specific consequences of actions, but how these are impl

73 Our data reveal the specific coupling between ENaC gamma-subunit and claudin

74 Furthermore, D1R-MSN-specific CRY-knockdown in the NAc reduced susceptibility

75 HRs for type-specific CVDs and <5.0-mg daily dose use were: 1.69 (95%

76 ng clinical sepsis, and contribute to tissue-specific cytokine responses that are protective against

77 of patients with MS and animal models of how specific cytokines produced by autoreactive CD4 T cells

78 ntigen Receptors (CAR) T cells demonstrating specific cytolytic activity.

79 ress this issue, we inflicted substantial DG-specific damage in mice of either sex either by diphther

80 had increased risk of recurrence and cancer-specific death.

81 Cell-specific deletion reveals a requirement for GATA6 in var

82 their biology, but also may permit the cell-specific delivery of small molecules to improve the post

83 ntexts in Kenya and Tanzania, using compound-specific delta(13)C and Delta(13)C values of the major f

84 determine the methylation status of the Treg-specific demethylated region (TSDR) have remained unchan

85 ) in amino-acid-deprived cells also leads to specific depletion of proteins containing polyglutamine

86 lar, the inability to access structures with specific diameters or chiralities severely limits their

87 homeostasis, and disease, but links between specific dietary fats and cell fates are poorly understo

88 tissue mechanics may better resolve disease-specific differences in adipose tissue fibrosis compared

89 Overall, we find that sex-specific differences in T(reg) cells from VAT are determ

90 iating SN cell type expression profiles with specific disease risk.

91 tablished that transcription factors bind to specific DNA sequences using a combination of base reado

92 During eukaryotic cell division, cyclin-specific docking motifs help cyclin-dependent kinases (C

93 mbly of a NucC homohexamer competent for non-specific double-strand DNA cleavage.

94 circumvented by CAR-T cells targeting tumour-specific driver gene mutations, such as the four-nucleot

95 In this study, we revealed that the specific DRs are involved in the production of specific

96 -HT1A/2A activation, either through receptor-specific drug intake, genetically predisposed irregular

97 ntial angiocrine interactions between tissue-specific ECs and other cell types by analyzing ligand an

98 This specific effect of lithium suggests that a targeted modu

99 , we examined whether H2A.Z cKO also has sex-specific effects on fear sensitization in the stress-enh

100 ranscription factors that may mediate tissue-specific effects.

101 For crop-specific emissions, the NH(3) EFs averaged 11.13%-13.95%

102 Conditional kidney tubule-specific ENaC gamma-subunit knockout mice displayed decr

103 ror of lysine degradation characterized by a specific encephalopathy that is caused by toxic accumula

104 for ESRRB in regulating the activity of ESC-specific enhancer units and propose that the development

105 ted and cysteine modified epitopes of neuron specific enolase (NSE), as-synthesized gold nanoparticle

106 rn schemas of category locations by encoding specific episodes.

107 The population-specific equations showed a lower interindividual variab

108 was used to quantitate the levels of epitope-specific (es)IgA, esIgE, esIgD, esIgG(1) , and esIgG(4)

109 he distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance.

110 We describe a specific example of a gAP in humans linked to individual

111 on quantitative trait loci (eQTL) and allele-specific expression (ASE) signals.

112 informs function, we generated mice with zG-specific expression of GCaMP3 and imaged zG cells within

113 and may have implications for tissue or cell-specific expression of the virus.

114 One of these methods, region-specific extraction (RSE) is characterized by the captur

115 reated neutrophils, suggesting that pathogen-specific factors may interact with an azithromycin-sensi

116 lasmodium falciparum manifests in many organ-specific fatal pathologies, including cerebral malaria (

117 We also found evidence for potential, SIB-specific FC signature, which may point to compensatory n

118 the concentration of pathogen genes and host-specific fecal markers.

119 Using G9Calpha(-/-)CD8(+) T cells specific for proinsulin, we studied the mechanisms by wh

120 timulate the production of potent antibodies specific for the pathogen through a Darwinian evolutiona

121 Here, we discovered site-specific fragmentation of NOTCH3 protein in pathological

122 rtery and its major branches; however, their specific functions are not well-understood.

123 ana seedlings were investigated using tissue-specific GA inactivation in wild-type (Col-0) or rescue

124 vian lineages, most genes belong to an avian-specific gamma-c clade, within which sequences cluster b

125 We identified specific gene combinations that were associated with dis

126 Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA vi

127 syndrome in mice bearing the Asah1 podocyte-specific gene deletion.

128 TCF binding sites are associated with cancer-specific gene dysregulation.

129 Information on molecular changes in cancer-specific gene expression facilitates efficient targeted

130 A specific gene expression profile, referred to as ECM3 (E

131 were the percentage of cases associated with specific genetic disorders and the proportion of variant

132 eceiving metformin-based background therapy, specific GLP-1 RAs and SGLT-2 inhibitors have a favorabl

133 ples, demonstrating its highly sensitive and specific glycoproteomics and phosphorproteomics analysis

134 regions in each subject to determine subject specific graph measures.

135 esting capacity, has prioritized testing for specific groups of persons.

136 ngs highlight that guidelines should include specific guidance on sampling schemes.

137 were scored for severity of skin condition, specific hair shaft defects, atopy, and recurrent infect

138 usly EuB(6) (possessing an anomalous peak in specific heat at low T, magnetic phase transitions, and

139 del for SmB(6) (mixed valent, with a peak in specific heat, and pressure induced magnetic phase trans

140 SINEs harbor a high density of the enhancer-specific histone mark H3K4me1 and carry sequences that m

141 ems allow a variety of bacteria to thrive in specific host environments.

142 ucible manner and functions in repression of specific HSF1 target genes.

143 cteria Pediococcus pentosaceus suppressed Ag-specific humoral and cellular responses.

144 ically-relevant molecules in the presence of specific IgG biomarker antibodies.

145 TAK-003 significantly increased DENV-2 NS1-specific IgG in naive individuals, which cross-reacted w

146 Knowing the concentration of SARS-CoV-2 S1-specific IgG is crucial in selecting appropriate convale

147 genic muscle-specific tyrosine kinase (MuSK)-specific IgG4 autoantibodies in autoimmune myasthenia gr

148 ever, awareness of this entity is low, and a specific imaging pattern has not yet been identified.

149 evolving viral reservoir along with an HIV-1-specific immune response seems to be key for the spontan

150 -thymic gammadeltaT17 development and tissue-specific imprinting, which is essential for infection an

151 We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow

152 inity do not provide any additional response-specific information.

153 ned to date, whereas G3 exhibits no sequence-specific insertion.

154 nt bacteria and achieved target- and species-specific integration in a complex bacterial community.

155 light on strategies for cell type- and stage-specific intervention in cardiac diseases.

156 se of amino acid quantitation and amino-acid-specific isotope ratio analysis of scalp hair of America

157 ) and CD4(+) T cell responses with S protein-specific killing activity were detected.

158 im, we generated Langerin-specific and CD11c-specific knockout ((-/-)) mice lacking AhR, respectively

159 Mice with a Purkinje-cell-specific knockout (KO) of the calcium-activated K+ chann

160 , high-affinity DNA aptamer generation, site-specific labeling of RNAs, semi-synthetic organism creat

161 epicardium-derived stromal cells (EpiSC) by specific ligands might enable the direct imaging of EpiS

162 lattening of caveolae could allow release of specific lipids into the bulk PM.

163 ingly, CLL driver genes are characterized by specific local wiring patterns not only in the CS networ

164 lts suggest that white matter disruptions at specific locations of the cingulum bundle may be a hallm

165 Still, the specific loci of these neural patterns differed between

166 aims to delineate proteomes in a proteoform-specific manner, which is vital for accurately understan

167 ates gene expression in a dynamic, cell type-specific manner.

168 Using cell-specific markers, we demonstrate that pericytes rather t

169 is phosphorylated by mTORC1 via a substrate-specific mechanism that is mediated by Rag GTPases.

170 apicoplast product, confirming an apicoplast-specific mechanism.

171 tion rate of (18)F-DCFPyL PET/CT, a prostate-specific membrane antigen (PSMA)-targeted PET agent, in

172 er 2-methoxy-(18)F-DCFPyL ((18)F-JK-prostate-specific membrane antigen [PSMA]-7) has shown favorable

173 actin filaments are directly associated with specific membranes.

174 cends global action by selectively promoting specific memories associated with local sleep oscillatio

175 Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics as

176 force, assess general (rather than condition-specific) messaging, and include health system strengthe

177 ughput approach, we have directly identified specific metabolites that exert transcriptional, transla

178 t study patients with FA exhibited a disease-specific metabolomic signature compared with both contro

179 c conjugation resulting in mixtures, or site-specific methods that require multiple steps, introducti

180 pigenomic deconvolution to perform cell type-specific methylome-wide association studies within subpo

181 ts of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in th

182 d in the context of trafficking, analysis of specific migratory behaviors of lymphocytes within the t

183 ene expression strategy to target cells with specific miRNA expression using miRNA-guided neuron tags

184 rated a doxycycline-inducible adipose tissue-specific MMP14 overexpression model to study its regulat

185 hermore, with CLASSED we developed a context-specific model of beta-adrenergic cardiac hypertrophy.

186 re responsible for the selective addition of specific modifications to the ascarosides.

187 Previous M2e-specific monoclonal antibodies (M2e-MAbs) show protectiv

188 We used cell-specific monoclonal antibodies to eliminate neutrophils,

189 trichocarpa based on targeted knockdowns of specific monolignol genes.

190 essive and invasive tumors with high disease-specific mortality.

191 ed in DNA replication by directly binding to specific motifs within their promoters.

192 suggest that health interventions targeting specific multimorbidity patterns may reduce mortality in

193 ions of variable instances tied to situation-specific needs.

194 bility to tailor microbial membranes to meet specific needs.

195 analysis technology to determine the parcel-specific neurite lengths of every neuron type from repre

196 siesta, is a "hard-wired" property gated by specific neurons of the master clock to favor subsequent

197 SARS-CoV-2-uninfected donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SA

198 Serum toxin A- and B-specific neutralizing antibodies were measured.

199 ody-mediated toxin neutralization and tissue-specific neutrophilic inflammation preserve tissue integ

200 ity is corroborated by experiments using the specific NKCC inhibitor bumetanide.

201 entification of hundreds of shared and tumor-specific non-canonical HLA peptides, including an immuno

202 ism triggered by the periodic provision of a specific nutrient by the mature host: each night the sym

203 usands of genetic variants exhibiting allele-specific open chromatin (ASoC).

204 sitic infections, some of which are parasite-specific, opens up new therapeutic possibilities.

205 We provide specific opportunities for pursuing these strategies thr

206 influenza A, however, they are either strain specific or have limited efficacy.

207 onal, Physical, and Overall Health) and four Specific Outcomes (Child Health-Related Quality of Life,

208 sitive maternal mental health in relation to specific outcomes.

209 Cardiac-specific overexpression of YAP rescues cardiac defects i

210 Efforts typically focus on specific packaging characteristics, or material attribut

211 and its contribution to CVD could depend on specific patient profiles.Objectives: To evaluate the ef

212 e states, but the metabolome reveals disease-specific patterns.

213 A multiplex allele-specific PCR targeting outbreak-specific single nucleoti

214 was then engineered with a novel and highly specific peptide nucleic acid (PNA) as the recognition e

215 information, (B) factors that relate to the specific person doing the analysis, which include past e

216 the plasma membrane once the peptide targets specific phospholipids found on the cytosolic side of th

217 gical relevance because it occurs only under specific physical conditions of high or low temperature

218 In study 2, this specific prefrontal-ventral striatal dysfunction was ass

219 address this issue, we followed the antigen-specific progeny of individual naive CD8+ T cells to the

220 asis and define the sperm and seminal plasma specific programming effects on cardiovascular health.

221 Finally, we report the primate-specific proline-rich domain to be dispensable for both

222 , and 4 are known to interact with ubiquitin-specific protease 7 (USP7); interactions of vIRF-1 and v

223 The unique family of DPC-specific proteases Wss1/SPRTN targets DPC protein moieti

224 ionally used a fluorescent variant of the LD-specific protein (PLIN2) that exhibits altered fluoresce

225 fect evaluation through in situ detection of specific protein oxidation by matrix-assisted laser deso

226 and at later times they co-express MC and EC-specific proteins and maintain graft patency.

227 ither the tissue samples were homogenized or specific proteins were selected for analysis of glycosyl

228 This contributes to sex-specific regulation of excitability, [Ca(2+)](i), and my

229 Our results unveil that the histotype-specific regulation of tumor fibrosis in lung cancer is

230 one modification, we identify neuron-subtype-specific regulatory elements that previously went undete

231 The Pearson's correlation results showed the specific relationship between individual FAs in forages

232 Site-specific replacement of active-site amino acids revealed

233 ectives on how these tools can be applied to specific research fields such as genome stability and de

234 suggests fly populations differ in E. muscae-specific resistance mechanisms as well as generic defenc

235 yo Clinic Laboratories not characterized for specific resistance mechanisms, and 128 isolates with CF

236 counteracts a previously unknown macrophage-specific restriction factor that targets and reduces the

237 es the ability to infer the current value of specific rewards after devaluation.

238 al variables to infer the causal effect of a specific risk factor on an outcome.

239 cells appear to play an early and regionally specific role of nerve fiber layer phagocytosis in areas

240 hese results suggest that Notch ligands play specific roles in the adult pancreas and highlight a nov

241 aves the way for future investigation of the specific roles of these proteins in SA signalling and th

242 S,5R,8R) by comparison with the NMR data and specific rotation of the synthetic compounds with that o

243 ed molecular dynamics simulations to examine specific secondary structures that resist mechanical unf

244 The IS-specific secreted proteases, ovochymase 2 (OVCH2) and A

245 Development of specific sensor technologies integrating nanomaterials o

246 establishing or maintaining this balance at specific set points.

247 ecific DRs are involved in the production of specific sfRNAs in both mammalian and mosquito cells.

248 On one hand, specific Ship1 inhibition enhanced calcium signaling and

249 R numbers available for binding, rather than specific signalling events.

250 iplex allele-specific PCR targeting outbreak-specific single nucleotide polymorphisms was applied to

251 Using allele-specific single-cell RNA sequencing, we here estimate th

252 Silencing NOX1 using NOX1-specific siRNA mitigated radiation-induced oxidative str

253 ntrolled by the MatP protein, which binds to specific sites (matS) within ter, and interacts with oth

254 model system for the potential use of allele-specific small interfering RNA in treating KID syndrome

255 Equivalence testing, using study-specific smallest effect sizes of interest, revealed tha

256 lastic compartment, and identify CAFs as the specific source of FGF1 in the tumor microenvironment.

257 Specific species of these lipids appear to be more negat

258 owed that qPCR-negative plants exhibited HLB-specific spectral characteristics that can be distinguis

259 This work shows that regulation of tissue-specific splicing can influence FXR1 condensates in musc

260 uation-free approach that does not presume a specific stock-recruitment relationship is better than S

261 xplained by transcriptional reprogramming of specific structural genes of the pathway.

262 Yet, this specific subset of patients remains poorly described.

263 ases opioid responsiveness in vitro within a specific subset of small-diameter nociceptors that bind

264 This effect was not retinotopically specific, suggesting that suppression of PM altered sens

265 sive lymphadenectomy leads to better disease-specific survival in patients treated with surgery alone

266 tions in TP53 are associated with poorer CRC-specific survival, which is most pronounced in cases car

267 erm maintenance of extraordinarily large CMV-specific T cell populations.

268 d STING, cocultured T cells expressing MCPyV-specific T cell receptors (TCRs) show increased cytokine

269 Total and spike-specific T cell responses correlated with spike-specific

270 SARS-CoV-2-specific T cell responses were driven by TCR clusters sh

271 We were able to detect SARS-CoV-2-specific T cells in 10 of 10 COVID-19 patients with mild

272 uctural affinity analyses of cytomegalovirus-specific T cells, and through the generation and in vivo

273 ify the epitopes targeted by clusters of Mtb-specific T cells, we carried out a screen of 3,724 disti

274 try was used to measure the frequency of EBV-specific T-cell responses between groups following stimu

275 y and transcriptional alterations of steroid-specific target genes at 96 and 120 h post fertilization

276 ventional means because of the difficulty in specific targeting/delivery to the tumor site.

277 Here, using our recently established mammary specific Tet2 deletion mouse model, the data reveals tha

278 hich was associated with suppression of lung-specific Th2 responses long after initial treatment.

279 le prostate specimens were imaged in patient-specific three-dimensionally printed molds by using 3-T

280 ic and probiotic approaches directed towards specific TLR2 signaling processes might be developed for

281 Cis-eQTLs are largely specific to cell type or stimulation, and 31% and 52% of

282 gments are comprised of methylation patterns specific to either prostate cancer or prostate normal ep

283 s beta-elimination/Michael addition, are not specific to O-glycan release and can also eliminate phos

284 rsus bent disulfide bond-containing CDRH3 is specific to particular HCV-infected individuals, we solv

285 e concept of risk-enhancing factors that are specific to women and are associated with an increased r

286 asets remains a challenge due to the lack of specific tools for doing so.

287 ir temporal evolution and potential to exert specific toxic activities.

288 test set; the remainder were used as domain-specific training data.

289 arying coefficient models to quantify region-specific trends in trait coordination and trait response

290 These results indicate that lipids engage in specific, trimer-stabilizing interactions that go beyond

291 hans multinucleated giant cells (LGCs) are a specific type of multinucleated giant cell containing a

292 r dyads considering LVAD were estimated in a specific type of structural equation model known as the

293 some heart transplant candidates listed with specific types of treatments.

294 Pathogenic muscle-specific tyrosine kinase (MuSK)-specific IgG4 autoantibo

295 DG granule cells (GCs) or by prolonged brain-specific VEGF overexpression culminating in extensive, h

296 (deep learning [DL] ventilation MRI)-derived specific ventilation maps as a surrogate of noble gas MR

297 e propagation and spatial dissemination of a specific virus (H1delta-2) that becomes dominant among e

298 lustrate how to extend the platform to model specific virus types (e.g., hepatitis C) and add additio

299 elp to unravel the mechanisms underlying sex-specific vulnerability in ALS-FTD.

300 Yet, it is not clear which specific WM processes are affected in this condition.

301 o matrigel plug assay, we then found that EC-specific YY1 ablation inhibited growth factor-induced an