ライフサイエンスコーパス: specific activity

1 synthesized in high radiochemical yield and specific activity.

2 nontoxic for healthy cell, indicating a high specific activity.

3 -ALT-836 was achieved in high yield and good specific activity.

4 bodies, the output regions exhibit stimulus-specific activity.

5 tant with nearly 3-fold higher H2 production specific activity.

6 3 that exhibits strong SMC-selective, allele-specific activity.

7 orylated substrates leads to enhanced kinase-specific activity.

8 sodine to norbelladine with a 400-fold lower specific activity.

9 eater than 98% radiochemical purity and high specific activity.

10 ke of (18)F-TFB in hNIS-expressing tumor and specific activity.

11 nge gives suboptimal radiochemical yield and specific activity.

12 of regulatory element activity and cell-type-specific activity.

13 is(monoacylglycero)phosphate (BMP) with high specific activity.

14 s of (89)Zr immuno-PET agents with increased specific activity.

15 al enhancer accessibility and late cell-type-specific activity.

16 catalytic versatility and stereo- and regio-specific activity.

17 e yield of 69.7% and more than 100 GBq/mumol specific activity.

18 ng features of cell- and developmental stage-specific activity.

19 variations in administered activity and the specific activity.

20 nstrated the general irrelevance of promoter-specific activities.

21 n than the wide type and displayed increased specific activities.

22 itable processing, with potential to improve specific activities.

23 ommon microbial patterns as well as pathogen-specific activities.

24 ganized into groups or layers that carry out specific activities.

25 )), a high mass activity (398 mA mg(-1)) and specific activity (0.98 mA cm(-2)), and a good If/Ib rat

26 lucose oxidase enzyme on filter paper strip (specific activity 1.4 U/strip) and then reacting it with

27 ts with conventional (18)F-DOPA-L with a low specific activity (11 +/- 2 GBq/mmol).

28 For high-specific-activity (11)C-GSK1482160, receptor density and

29 al evaluated the efficacy and safety of high-specific-activity (131)I-meta-iodobenzylguanidine (HSA (

30 rformed a direct comparison of high- and low-specific-activity (18)F-DOPA in a neuroendocrine tumor m

31 The synthesis of high-specific-activity (18)F-TFB should enable future clinica

32 carbon, achieved a mass-specific and surface-specific activity, 3 and 2.5 times, respectively, as hig

33 is method, yielding (18)F-DOPA-H with a high specific activity (35,050 +/- 4,000 GBq/mmol).

34 face, PK-R371A converts FXII to FXIIa with a specific activity ~4 orders of magnitude lower than for

35 in good radiochemical yields (15-39%), high specific activities (45-95 GBq/mumol), and excellent rad

36 ckel precatalyst provided unprecedented high specific activities (50-99 Ci/mmol) in radiolabeling, me

37 order to isolate the small mass of (211)At (specific activity = 76 GBq.ug(-1)) from several grams of

38 99m)Tc from non-fission reactor-produced low-specific-activity (99)Mo.

39 Preparation was achieved containing specific activity about 60 times higher than that of the

40 l pH, Brownmillerite Sr(2)GaCoO(5), with the specific activity about one order of magnitude higher th

41 trastuzumab was shown to be achievable at a specific activity above the reported literature value of

42 lly induced hypoxic conditions, displaying a specific activity against cancer cells characterized by

43 Its specific activity against liver and blood stages of Plas

44 pace, and can be tuned for broad-spectrum or specific activity against microorganisms.

45 rrow spectrum molecule with a unique species-specific activity against Pseudomonas aeruginosa.

46 Carolacton has remarkably specific activity against S. mutans, causing acid-mediat

47 reens in embryos, to identify compounds with specific activity against tet2 mutant cells.

48 n different tissues and have distinct tissue-specific activities and functions.

49 nstructs were evaluated in production level, specific activities and kinetic parameters.

50 ctional gamma-secretase complexes displaying specific activities and maturations.

51 systems, including engineered molecules with specific activities and model systems that mimic complex

52 under all conditions had similar ecto-enzyme specific activities and types of RNA, and all ACVs conta

53 ACSL1 deficiency caused a 91% loss of ACSL-specific activity and a 60-85% decrease in muscle FA oxi

54 The MYB81 promoter shows microspore-specific activity and a MYB81-RFP fusion protein is only

55 observed high hydrolysis yields to the high specific activity and affinity of the individual enzymes

56 sociated with an 8-17-fold increase in VLCAD-specific activity and concomitant correction of acylcarn

57 vity and binding assays demonstrated reduced specific activity and decreased binding of the novel N9

58 ide (BF3) to enhance both labeling yield and specific activity and evaluation of specific activity in

59 a small volume, while maintaining high area-specific activity and favourable pore-transport properti

60 radiochemical yields, with 40-207 GBq/mumol specific activity and greater than 95% radiochemical pur

61 tive fluorophores has allowed for imaging of specific activity and has helped elucidate mechanisms of

62 sily synthesized in high yield and very high specific activity and is a promising candidate for precl

63 ial, SrCoO2.7, with a high, room temperature-specific activity and mass activity towards alkaline wat

64 (67%) mice treated with intermediate or high specific activity and none of 6 (0%) mice treated with l

65 ced by increasing alkaline phosphatase (ALP)-specific activity and osterix, runt-related transcriptio

66 Their specific activity and regioselectivity were studied in t

67 r-DFO-cetuximab were prepared with increased specific activity and retained purities of 95% after 3 d

68 The enantiomer-specific activity and straightforward chemical synthesis

69 d for a commercial Pt/C electrocatalyst, the specific activity and the electrochemical surface area f

70 tion (ORR) requires optimization of both the specific activity and the electrochemically active surfa

71 on branched Ni nanoparticles exhibited high specific activity and the highest mass activity for hydr

72 tome varies by cell type, reflects cell type-specific activities, and is considerably broader than pr

73 efficiency (radiochemical yield and purity, specific activity, and radio-scalability).

74 tch mode, evaluating the enzyme loading, the specific activity, and the kinetic parameters in model w

75 it uses unique elements to mediate substrate-specific activity, and use NAT-type specific auxiliary a

76 ubling time, administered antibody, antibody specific-activity, and antigen-site density most impacte

77 ny synthetic compounds to which we attribute specific activities are produced as racemic mixtures of

78 ons were focused on the regional and country-specific activities associated with stroke prevention an

79 and found that the proteases exhibit similar specific activities at 25 degrees C.

80 lms of SrIrO3 This catalyst has demonstrated specific activity at 10 milliamps per square centimeter

81 half-life at 60 degrees C, 5-fold increased specific activity at 65 degrees C, 1.3-fold improved kca

82 The reaction is showcased in the high specific activity automated synthesis of the RARbeta2 ag

83 Using a trypsin-specific activity-based probe, we detected three distinc

84 yielded detectable products, nearly all had specific activities below 10% of the reference natural P

85 We demonstrate a 2.3-fold enhancement in specific activity by 60- and 30%-ordered Pt(3)Sn nanocub

86 iants that display significantly reduced non-specific activities compared with its wild-type counterp

87 results in a more pronounced decline in VieA specific activity compared to the classical biotype.

88 eLa cells, where it showed a markedly higher specific activity compared with PLD4.

89 We propose that this cell-type-specific activity coordinates the development of the fun

90 basal ganglia have suggested that frequency-specific activities correlate with force or effort, but

91 entified and the peptides were found to have specific activities defined by the relative magnitude of

92 esults show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendrit

93 treatment with a low dose of the potent and specific activity-dependent mGluR1-negative allosteric m

94 nsorimotor circuits that do not require task-specific activity-dependent plasticity.

95 esynaptic NMDARs allows to implement synapse-specific, activity-dependent lateral inhibition, and thu

96 pport an alternative model: BMPs have signal-specific activities directing particular IN fates.

97 Additionally, low specific activity due to poor labeling efficiency can re

98 expose neuronal projection- and compartment-specific activity dynamics that encode and predict actio

99 d, and these recent findings begin to define specific activities for Maf1 in multicellular organisms

100 e same enzyme include the following: (i) the specific activity for both substrates was comparable in

101 The specific activity for catalyzed CO evolution systematica

102 n systematically rises by three-fold and the specific activity for catalyzed H2 evolution systematica

103 The specific activity for hydrogen evolution diminishes by 1

104 etics, revealing highly variable and context-specific activity for the DNA methylation machinery.

105 Ni(111) surface, which has the highest known specific activity for the oxygen reduction reaction, is

106 ce of surface-area-normalized activity (i.e. specific activity) for intrinsic chemistry analysis.

107 lin 1/Noggin and their production as defined specific activities free of contaminants that may affect

108 tor, affording the radiopharmaceuticals with specific activities greater than 1,000 MBq/nmol.

109 decay-corrected radiochemical yield = 31.6%, specific activity >/= 48.5 GBq/mumol).

110 cal yields and purity (>98%) as well as high specific activities (>20 GBq/mumol).

111 s with high radiochemical yield (>87%), high specific activity (>/=9.8 MBq/nmol), and purity (>99%).

112 odel to determine whether this difference in specific activity has implications for the biologic beha

113 thways are poorly understood because pathway-specific activity has rarely been monitored during a per

114 18)F-labeled hNIS substrates offering higher specific activity, higher affinity, and simpler radioche

115 18)F-labeled hNIS substrates offering higher specific activity, higher affinity, and simpler radioche

116 ol antibody, gave potent and immunologically specific activities in vitro and in vivo.

117 After testing candidate SNPs for allele-specific activity in a luciferase-based enhancer scannin

118 fMRI studies focusing on saccade- and reach-specific activity in human cortex, however, provided con

119 n infant, was associated with greater infant-specific activity in key parental brain regions, includi

120 ted variants demonstrated significant allele-specific activity in reporter assays.

121 ing neurons with sex- and reproductive state-specific activity in sustaining the increased food intak

122 pproach for non-invasive assessment of layer-specific activity in the human motor cortex.

123 usion was supported by the fact that the APC-specific activity in the medium of COS-1 cells is exclus

124 in vivo introduced enhancers with cell-type-specific activity in the mouse retina.

125 that top-down signals elicit retinotopically specific activity in visual cortex both in the dorsal an

126 because of their capacity to stimulate tumor-specific activity in vivo.

127 )I]NaI, where products were isolated in high specific activity in yields ranging from 46% to 86%.

128 (177)Lu-PSMA-617 (120 MBq) with high specific activity induced superior tumor growth inhibiti

129 ield and specific activity and evaluation of specific activity influence on tumor uptake.

130 d and recombinant FVIII-SQ showed comparable specific activity (international units per milligram) in

131 ns of the absorbed doses showed that a lower specific activity is associated with a lower single-cell

132 ermine that their diverse phosphate position-specific activity is governed by the phosphatase domain.

133 Second, kinase-specific activity is inversely correlated with substrate

134 pathway contributes to the pathway's context-specific activity is not known.

135 The molecular basis for ERG lineage-specific activity is unknown.

136 anscripts, we conclude that the mechanism of specific activity is unlikely to be based simply on pref

137 The V1 location-specific activity leads hippocampal place cell activity

138 d tropicamide also produced increases in non-specific activity levels, whereas biperiden did not.

139 half-life, 635 keV positron energy) and high specific activity make it an attractive nuclide for labe

140 rgy and fluid homeostasis by using cell-type-specific activity manipulations in mice.

141 ith a lower single-cell dose, whereas a high specific activity may result in a lower central dose in

142 evaluated, and the results obtained via BChE-specific activity measurements were confirmed by quantif

143 pies that target individual proteins rely on specific activity-modulating interactions with the targe

144 th radiochemical purity greater than 98% and specific activities of 326 +/- 20 MBq/nmol are obtained

145 ferred to here as clade 3, displayed average specific activities of 4.2 and 1.2 U/mg on lichenan and

146 ical yields relative to (18)F-fluoride, with specific activities of 666 +/- 51.8 GBq (18 +/- 1.4 Ci)/

147 Specific activities of 8.84 +/- 0.56 GBq/mumol (n = 3) w

148 RA biosynthesis in P. campanularia involves specific activities of a BAHD acyltransferase and two cy

149 Specific activities of both intracellular dehydrogenase

150 Whereas the specific activities of DGATs were similar with most of t

151 This study provides evidence that the cell-specific activities of different PKM isoforms generated

152 Although domain-specific activities of EAPs have been extensively studie

153 mechanisms that contribute to the cell type-specific activities of glucocorticoids.

154 was achieved without an incubation period at specific activities of less than 148 MBq/mg; however, sp

155 These DNA structure-specific activities of RecQ helicases are mediated by th

156 Yet, the role/s and specific activities of these different proteins remain t

157 of vesicular stomatitis virus RNA synthesis, specific activities of viral RNA synthesis were correlat

158 However, the high-specific activity of (249)Bk (t1/2 = 320 d) causes oxida

159 Ni/C showed the best ORR performance, with a specific activity of 10.3 mA/cm(2) and mass activity of

160 SA of 118 square meters per gram of Pt and a specific activity of 11.5 milliamperes per square centim

161 , radiochemical purity greater than 99%, and specific activity of 111-148 MBq/mg.

162 nalysis was greater than 98%, with a minimum specific activity of 12.6 and 42 GBq/mumol, respectively

163 radiochemical purity of 96.7% +/- 2.0%, and specific activity of 14.6 +/- 6.5 GBq/mumol.

164 de (H(2)O(2)) with a K(m) of about 13 mM and specific activity of 1470 +/- 75 mumol/min/g.

165 ize with a high radiochemical purity (>99%), specific activity of 2.2 mCi/mg of NP, and high stabilit

166 NWs show mass activity of 1.72 A mg(-1) and specific activity of 2.49 mA cm(-2) for MOR, which are 3

167 adiochemical yield (decay-corrected), with a specific activity of 279 +/- 75 GBq/mumol.

168 ultrafiltration and gel filtration showed a specific activity of 2793 U/mg.

169 wing to the maximized metal utilization, the specific activity of 2D-Mo(2)CO(x)/SiO(2) exceeds that o

170 radiochemical purity of more than 97% and a specific activity of 3,700 MBq/mg and retaining biochemi

171 0-35% (n > 20, non-decay corrected) and high specific activity of 40-111 GBq/mumol (1.1-3.0 Ci/mumol)

172 P2'GT of Malus x domestica (MdP2'GT) with a specific activity of 46.82 mukat/Kg protein toward phlor

173 A specific activity of 55.5 MBq/nmol (0.37 MBq/mug) was re

174 he porous support, the Fe-N-C SAN provided a specific activity of 57.76 U mg(-1), which was almost at

175 in 50 min (uncorrected radiochemical yield, specific activity of 815 +/- 185 GBq/mumol).

176 ch has a mass activity of 3.1 A/mg(Pt) and a specific activity of 9.3 mA/cm(2) at room temperature wi

177 LLPS increases the specific activity of actin regulatory proteins toward ac

178 Moreover, excessive doses of PN reduce the specific activity of AGT in a PH1 cellular model.

179 -specific unnatural amino acids, and species-specific activity of AimB.

180 The specific activity of AnGDH for xylose at 5mM concentrati

181 sults: (111)In-DOTA-5D3 was synthesized with specific activity of approximately 2.24 +/- 0.74 MBq/mug

182 d (68)Ga was straightforward, resulting in a specific activity of approximately 20 GBq/mumol and a ra

183 nd show that this projection modulates place-specific activity of CA1 neurons and their responses to

184 d enables active cargo loading, improves the specific activity of cargo delivery, and facilitates Gec

185 The specific activity of chromate reductase, NfoR, from Stap

186 rate and spectra are low, suggesting tissue-specific activity of common mutational processes through

187 Mechanism and sport-specific activity of concussion.

188 e data provide fundamental insights into the specific activity of glucan phosphatases against diverse

189 cularly with regards to the cell and context-specific activity of HIFs and PHDs.

190 alking was slightly enhanced as well as some specific activity of knee flexor muscles.

191 ture optimum for activity of the enzyme, the specific activity of lipase decreased.

192 The division-specific activity of lytic transglycosylases has implica

193 hydrate to monomeric residues, abrogated the specific activity of M. tuberculosis whole-cell lysates,

194 ng potentiates synaptic transmission and cue-specific activity of medial prefrontal cortex somatostat

195 plasticity is associated with parallel cell-specific activity of MMP-2 and MMP-9.

196 CR3022 with a purity of more than 98% and a specific activity of more than 292 MBq/mg.

197 upregulated in pDCs, correlating with stage-specific activity of multiple enhancer elements.

198 Moreover, the specific activity of overall LPCAT1 and DGAT1-1 coupling

199 tudy was to investigate the influence of the specific activity of preparations of both tracers on in

200 diverse endocytic pathways and measure stage-specific activity of processing factors in endosomes.

201 ydrogen oxidation reaction mass activity and specific activity of Ru(7)Ni(3)/C, as measured in rotati

202 We demonstrate in-vivo cell-type-specific activity of Six1-bound novel enhancers of Pbx1,

203 Using this approach, we identify miRNA-specific activity of target sites within the open readin

204 aging yeast cells by tracking the generation-specific activity of the canonical GAL1 promoter.

205 an essential residue for catalysis, with the specific activity of the enzyme being completely abolish

206 In optimal conditions, the specific activity of the free and immobilized pectinase

207 The specific activity of the plasma-engraved Co3 O4 nanoshee

208 is; microinjection; validation of the target-specific activity of the sgRNAs; founder screening to id

209 in the esk1 mutant deregulates the position-specific activity of the xylan glucuronosyltransferase G

210 The specific activity of the xylanase was decreased by intro

211 her explore the basis for phosphate position-specific activity of these enzymes and determine that th

212 rt of metformin across membranes, but tissue-specific activity of these transporters in vivo is incom

213 The specific activity of this compound was 853 +/- 29.6 GBq/

214 similar to that of Arabidopsis SFR2, but the specific activity of tomato SFR2 in vitro is almost doub

215 The specific activity of TopA expressed from His-tagged fusi

216 achieved via the coordinated and temporally specific activity of two prominent cognitive control bra

217 scription factor DeltaFosB drives projection-specific activity of ventral hippocampus glutamatergic n

218 Accordingly, a significant increase in the specific activity of Vps34 lipid kinase was observed aft

219 We uncover specific activity of zebrafish-derived drl reporters in

220 For mass doses (specific activities) of less than 20 pmol (>1,000 MBq/nm

221 The 5a and 5e compounds was showing the more specific activity on L-type calcium channels, i.e. A7r5

222 alpha-3,6-anhydro-d-galactosidases that have specific activity on red algal neo-carrageenan oligosacc

223 grafted tumors to determine the influence of specific activity on tumor uptake.

224 e typically attributed to changes in protein specific activity or abundance.

225 ity and none of 6 (0%) mice treated with low specific activity or formulation demonstrated significan

226 nically simple, the marked changes in plasma specific activity or the tracer-to-tracee ratio, if stab

227 ntermediate, 31 MBq/nmol; or low 15 MBq/nmol specific activity) or total activity (30, 60, or 120 MBq

228 from changes in protein sequence that alter specific activity, or from changes in gene expression th

229 r the reduction of O(2) to H(2)O, delivering specific activities over 35x higher than those of commer

230 achieving an order of magnitude increase in specific activity over commercial catalysts for methanol

231 arity of these patterns motivated the use of specific activity pattern shapes to classify entorhinal

232 The analysis of cell type-specific activity patterns during behaviors is important

233 r off neurons of interest, but to manipulate specific activity patterns hypothesized to regulate defe

234 real-time fMRI neurofeedback to induce color-specific activity patterns in early visual cortex as par

235 se shapes the relative arrangement of finger-specific activity patterns in sensory-motor cortex.

236 tral midline thalamus abolished only the SWM-specific activity patterns that were seen during dual-ta

237 Although the spatial layout of finger-specific activity patterns was variable across participa

238 stimuli are represented in sparse, stimulus-specific activity patterns, relatively little is known a

239 evealed chemotherapeutic and tumor cell line specific activity patterns.

240 The specific activity per ECSA of each material is also repo

241 st OER catalysts showed comparable or better specific activity per ECSA when compared to Ir and Ru ca

242 Topographically specific activity persists as early as V1, and activity

243 llatory entrainment, as visible in frequency specific activity phase-locked to stimulation offset.

244 The effects of improving the specific activity, prolonging residence time by introduc

245 ully radiolabeled with a PET nuclide at high specific activity, radiochemical purity, and yield.

246 Our results show that high-specific-activity radiolabeled mAbs that are bound to a

247 of FIX-Padua with an 8- to 12-fold increased specific activity reaching 25% to 40% activity without a

248 foundly altered in physiological Ca(2+), but specific activity regimes restore a classical STDP profi

249 ot known whether there are species- or clade-specific activity-regulated genes that control features

250 ate that this polymerase undergoes extensive specific-activity regulation in the initial and final tr

251 an excitatory neuron-specific but non-layer-specific activity reporter.

252 s to identify tissue-specific and temporally specific activities required to obtain the individual sh

253 for 10k cycles; 8.5 times and 13.8 times for specific activity, respectively, compared to commercial

254 for high, intermediate, and low (each n = 3) specific activity, respectively.

255 Heading was the most common soccer-specific activity, responsible for 30.6% of boys' concus

256 ence divergence as a factor, including human-specific activity-responsive AP-1 sites.

257 High when compared with intermediate or low specific activity resulted in a lower mean +/- SEM tumor

258 nclusion:(177)Lu-PSMA-617 (120 MBq) and high specific activity resulted in the highest efficacy in a

259 3-3 in NIH3T3 cells led to decrease in DNMT1 specific activity resulting in hypomethylation of the ge

260 eveal that prior expectations evoke stimulus-specific activity selectively in the deep layers of the

261 Further analysis showed that the WAVE1-specific activity stemmed from an inhibitory effect on f

262 total protein in the sample and calculating specific activity substantially improved quantification

263 Recently, more-specific activities such as road-tunnel washing have bee

264 as well as in their level of anxiety towards specific activities, such as mathematics and spatial tas

265 ubstantial ( approximately 85%) reduction in specific activity, suggesting that FAS inhibits OGA.

266 A rapid, practical, and high-specific-activity synthesis of the NIS reporter probe (1

267 sis of T2O from T2, providing access to high-specific-activity T2O.

268 Exg8 has a higher specific activity than Eng1 for beta1,3-glucans; yet des

269 , while most HER catalysts showed much lower specific activity than Pt in both acidic and alkaline so

270 e SiO(x) sites exhibit up to 3.5-fold higher specific activity than the parent alumina with identical

271 The locus shows allele-specific activity that is concomitantly modulated by and

272 s) from PFC and PAR reflect stimulation site specific activity that is largely insensitive to changes

273 ded (18)F-fluoride, yielded a product with a specific activity that was 3 orders of magnitude higher

274 For lower specific activities, the penetration rate and dose distr

275 by which cellular Mn:Zn ratios dictate PhpP specific activity thereby regulating pneumococcal cell d

276 a polar lipid fraction with highly enriched specific activity; this activity was further enriched by

277 Hippocampal place cells show position-specific activity thought to reflect a self-localization

278 nover to generate clearly resolved substrate-specific activity thresholds, which in turn ensures the

279 ion, thus maintaining near-constant ribozyme specific activity throughout protocell growth.

280 We traced part of the BRD2-specific activity to a previously uncharacterized short

281 e disease is poorly understood and few UCHL1-specific activity tools exist.

282 s exhibited 4.4-fold enhancement in terms of specific activity toward oxygen evolution relative to hc

283 The purified scFvs showed specific activity towards alpha-syn fibrils and oligomer

284 n allosterically triggers an increase in the specific activity (turnover rate) of the membrane-bound

285 activities of less than 148 MBq/mg; however, specific activities up to 592 MBq/mg could be achieved w

286 , the catalytic activity of BaGa(2) (surface specific activities up to 8390 h(-1)) is on the same ord

287 The (14)C specific activity varied from 280.4 Bq kg(-1) C in 2010

288 The highest specific activity was found on 6th day, with 33.08 U on

289 This cue-specific activity was independent of motor-related activ

290 By leveraging this specific activity, we demonstrate that abolishment of th

291 In addition, total PDE- and PDE3-specific activities were not altered in pediatric IDC pa

292 ~80 ms, suggesting early peaks reflect site-specific activity, whereas late peaks reflect activity p

293 for quantifying butyrylcholinesterase (BChE) specific activity which is BChE activity normalized to t

294 ntrinsic activity is commonly defined as the specific activity which is the current per unit catalyst

295 rin expression levels by virtue of adjusting specific activity, which can be exploited for visualizat

296 A maximum of 40% enhancement in the apparent specific activity, which corresponds to 10-fold enhancem

297 Designing BMP mimetics with specific activity will contribute to the translational p

298 formulated, cost-effective media of defined specific activity will engender the development of novel

299 and Sulfolobus solfataricus display sequence specific activity, with a clear preference for the nucle

300 cell-bound radionuclides, an increase in the specific activity would further increase the tumor dose