ライフサイエンスコーパス: specific binding

1 opolymerized benzoic acid (BA), to avoid non-specific binding.

2 biodistribution data further validated tumor-specific binding.

3 cules of the shape consistent with the motif specific binding.

4 critical molecular elements for the subtype-specific binding.

5 d mismatch DNA sequences, overcoming the non-specific binding.

6 take remained unchanged, demonstrating PD-L1-specific binding.

7 imal blocking buffer for restraining the non-specific binding.

8 a benchmark to distinguish specific from non-specific binding.

9 leotide polymorphisms associated with allele-specific binding.

10 t for accurate quantification of (11)C-UCB-J-specific binding.

11 the sensor surface was blocked to avoid non-specific binding.

12 mRNAs by FUS that does not involve sequence-specific binding.

13 erns of magnetic dipoles that are capable of specific binding.

14 IDPs) often fold into stable structures upon specific binding.

15 o bestow an advantage for weak, sequence non-specific binding.

16 Based on this specific binding, a soluble oligomer-binding assay (SOBA

17 ls were fabricated into thin films and their specific binding ability was tested.

18 The erythrocyte-specific binding activities of PvGAMA were significantly

19 ious quinolones with high specificity, while specific binding activities to structurally unrelated dr

20 SILC quantitatively predicts residue-specific binding affinities to nanoparticles and it expr

21 sets reporting protein copy numbers and site-specific binding affinities.

22 of aromatic side-chains fine-tunes sequence specific binding affinities.

23 Modeling this behavior provides site-specific binding affinities.

24 tration with metal ions correlate with their specific binding affinity and capacity.

25 ugs to Plec-1-derived peptide would increase specific binding affinity and impart high specificity fo

26 First, we developed DNA aptamers with specific binding affinity to chicken CD40 extra domain (

27 The ITs demonstrated specific binding against native antigens on persistently

28 niques rely on fluorescent labels or protein-specific binding agents to signal conformational changes

29 o modulation of the bilayer properties or to specific binding and allosteric regulation of protein ac

30 Our mechanistic results on site-specific binding and catalysis together with the lack of

31 that this motif is non-essential for damage-specific binding and DNA bending.

32 ize 64 candidate variants and perform allele-specific binding and expression analyses at seven top ca

33 We annotate variants associated with allele-specific binding and expression in 382 individuals by un

34 rized four nanobodies that present tight and specific binding and internalization into PSMA(+) cells

35 Resistance correlated with lack of specific binding and reduced oligomerization of Cry1Ac i

36 Aside from individual sequence-specific binding and regulation, examples of interaction

37 de moieties on particle surfaces through the specific binding and subsequent release of small reporte

38 res of T cell receptors that mediate epitope-specific binding and T cell activation.

39 peptide and protein aggregation can obscure specific binding, and since non-stoichiometric binding n

40 nt of the second site enables high-affinity, specific binding; and subsequent conformational rearrang

41 study injection (full analysis set) and Env-specific binding antibodies in all participants who rece

42 se measures included cross-clade and epitope-specific binding antibodies, neutralising antibodies, an

43 The primary endpoints were Env-specific binding antibody responses at weeks 28, 52, and

44 utations were nine times enriched for mutant specific binding, as compared with non-synonymous SNV de

45 Levels of specific binding, as measured by the nondisplaceable bin

46 l approach, called BEAPR, to identify allele-specific binding (ASB) events in eCLIP-Seq data.

47 ture-activity relationship (SAR) effort, and specific binding assessment using a LC-MS/MS "cold trace

48 nteractions, which are often obscured by non-specific binding at concentrations approaching in vivo a

49 uding HNF4A, GR, STAT3 and STAT5, which show specific binding at enhancer and super-enhancer sites, r

50 riven by nonspecific nucleosome binding with specific binding at nucleosome edges.

51 61%) has been identified to contain the WRI1 specific binding AW motif.

52 Specific binding between biomolecules, i.e., molecular r

53 The specific binding between short peptide fragments may pro

54 Specific binding between the extruded hairpin and a dist

55 o co-immunoprecipitation assays demonstrated specific binding between UBP12/UBP13 and ORE1.

56 le kinetics in nonhuman primates, as well as specific binding blockable by a PDE2A inhibitor.

57 Isoform-specific binding by CpE causes dissociation of claudins

58 these "metalloriboswitches," emphasizing ion-specific binding by structured RNA aptamers and associat

59 and lymphoma precursor lesions require site-specific binding by the BCL6 transcriptional repressor a

60 the substrate pTyr in EGFR and HER2 mediate specific binding by the SHP2 active site, leading to blo

61 Specifically, we interrogated site-specific binding by the transcription factor PU.1 and it

62 Flow cytometry examination revealed the specific binding capacity of fluorescein isothiocyanate-

63 truction of electronic devices, due to their specific binding, catalytic, nucleating or electronic pr

64 all protein biomarkers, while minimizing non-specific binding compared to more commonly used strategi

65 al structures can be used to screen them for specific binding compatibility with protein targets, as

66 e to complement the crystal structure of the specific binding complex, providing a basis for understa

67 with naloxone leads to a marked decrease in specific binding, confirming the discovery of a new temp

68 Although NMDAR-specific binding could be demonstrated for [(125)I]11d a

69 of the impact of ChIP-seq designs on allele-specific binding detection and highlights the power of p

70 ic features, peak identification, and allele-specific binding detection.

71 y, peak resolution, and most notably, allele-specific binding detection.

72 However, other ligand-specific binding determinants optimize CrmD for the inhi

73 neural cell populations by deleting its non-specific binding domain and replacing it with a C. botul

74 Therefore, adding protein-specific binding domains to DNA nanostructures can be us

75 y with two different membranes through lipid-specific binding domains, suggesting a general mechanism

76 landscape is correlated with the underlying specific binding energies.

77 Specific binding events of target analyte induced collis

78 The technique is sensitive to surface-specific binding events which we demonstrate through bio

79 dentify activators and blockers with strong, specific binding for engineering and therapeutic applica

80 ng patterns in DNA that can mediate sequence-specific binding for proteins such as transcription fact

81 r imaging BACE1 in the brain and showed high specific binding in an initial assessment in a nonhuman

82 , (18)F-OF-NB1 displayed a heterogeneous and specific binding in GluN2B subunit-rich brain regions su

83 Substantial TrkB/C-specific binding in human brain tissue is observed in vi

84 to rs6971 when tested in vitro and had high specific binding in monkey brain.

85 tions, shows optimum specific and little non-specific binding in phosphate buffered saline.

86 tumor uptake for [(68)Ga]6 and [(68)Ga]8 and specific binding in small-animal PET studies.

87 lent brain permeability, and a high level of specific binding in the "cold tracer" study.

88 mer disease (AD) and found a 41% decrease in specific binding in the hippocampus compared with health

89 ith preclinical studies showing little to no specific binding in the region.

90 sion: (11)C-AS2471907 has a high fraction of specific binding in vivo in humans and reasonable within

91 properties of fast uptake kinetics and high specific binding in vivo.

92 e that specifically targets GRP78 for cancer-specific binding (in vitro) and noninvasive tumor imagin

93 se of (+)-pentazocine abolished (11)C-Me-NB1-specific binding, indicating an indirect effect of Sigma

94 Unlike those methods, PLIMSTEX provides site-specific binding information.

95 The bio-specific binding interaction among the molecules was inv

96 ramide regulates the ORMDL-SPT complex via a specific binding interaction.

97 y in the one state of the photoswitch, while specific binding is completely switched off in the other

98 Specific binding is inhibited by a L348R mutation in Mun

99 Specific binding is monitored with a localization precis

100 rtical flow phase that acts on proteins with specific binding lifetimes.

101 This increase is achieved while keeping non-specific binding low as established in control tests wit

102 We selected FcgammaRIIB-specific binding molecules from a library of designed an

103 increased affinity of the holo-DnrF for its specific binding motif in the napD promoter.

104 A method was developed to identify disease-specific binding motifs through integration of bacterial

105 partition based on their size, polarity, and specific binding motifs.

106 In this manner, we identified a specific "binding network" that can regulate movement of

107 winding of RNA:DNA hybrids is due to neither specific binding nor differences in the rate of strand s

108 Specific binding of (11)C-BMT-136088 can be reliably mea

109 Specific binding of (18)F-fallypride to hD2R hMPCs was d

110 ng aged, female, retired breeder rats showed specific binding of (64)Cu-DOTA-alendronate in mammary g

111 Ex vivo autoradiography demonstrated specific binding of (64)Cu-DOTA-ECL1i to CCR2 in both ra

112 release was quantified as the difference in specific binding of [(11)C]raclopride (nondisplaceable b

113 Specific binding of [(18)F]3 to CB2 was demonstrated by

114 is a prerequisite for the subsequent highly specific binding of a second RR dimer to the low-affinit

115 We suggest that specific binding of a sphingolipid to the p24 transmembr

116 e maintaining it in an "off" state until the specific binding of a true substrate.

117 activation and inhibition occur via subunit-specific binding of agonists and antagonists remain larg

118 The specific binding of an MIP to a nonimprinted polymer (NI

119 procedure was optimized to eliminate the non-specific binding of antigen on the membrane surface.

120 Here, we report the high-affinity and specific binding of BMVC to MycG4 with unusual slow-exch

121 nsor does not have significant levels of non-specific binding of bovine serum albumin and human serum

122 ular dynamics simulations to investigate the specific binding of cardiolipins to yAAC3.

123 cacy, the long circulation half-life and non-specific binding of cytotoxic ADCs can result in systemi

124 Here, we use the programmable and specific binding of dye-labeled DNA probes to count inte

125 ) binding protein 2 (PCBP2), and starts with specific binding of eIF4G/eIF4A to d11.

126 Specific binding of ENTH to phosphatidylinositol 4,5-bis

127 ly, in vivo imaging did not show measureable specific binding of F-Dapa in heart, muscle, salivary gl

128 among cats is FeLV subgroup A (FeLV-A), and specific binding of FeLV-A Env to its viral receptor, th

129 Receptor-specific binding of gallium-labeled HZ220 was characteri

130 ith chemical analogues of synaptamide reveal specific binding of GPR110 to synaptamide, which trigger

131 Specific binding of graphene quantum dot with Campylobac

132 onformational change in the DNA aptamer upon specific binding of HA protein may alter the surface pot

133 Specific binding of hGal-3C to each GP was successfully

134 hange in the sequence of ES9S endows species-specific binding of Hoxa9 mRNA to the ribosome.

135 ed hd-anti-IFN-gamma-induced increase in the specific binding of IFN-gamma to its receptor in U937 ce

136 Specific binding of inhibitor compound VU0463271 was dem

137 mouse peritoneal macrophages, confirming the specific binding of L-Enano to the macrophage CD36 recep

138 gene promoters and found that while sequence-specific binding of late gene promoters requires ORF24,

139 The specific binding of ligands by proteins and the coupling

140 nization in the cell relies on the rapid and specific binding of molecules to their cognate targets.

141 The UPAR specific binding of MSN-UPA nanoparticles was confirmed

142 del, and subsequent testing has verified the specific binding of multiple docking hits to this site.

143 lipid monolayers allowed confirmation of the specific binding of myristoylated recoverin to phosphati

144 models of neurotransmission are based on the specific binding of neurotransmitters to ligand-gated re

145 Non-specific binding of NPs to tumor ECM components was asse

146 A general method for sequence-specific binding of peptides remains elusive despite dec

147 tion of the SF1 SPSP motif slightly enhances specific binding of phospho-SF1 to its cognate U2AF(65)

148 te selection is directed in part by sequence-specific binding of PRDM9, a polymorphic histone H3 (H3K

149 ion of adjacent residues that facilitate the specific binding of proteins and modulate the global fol

150 To detect any NR2B-specific binding of radioligand in brain, various preblo

151 Loss of HMGNs preferentially reduces the specific binding of REX1 to these chromatin regulatory s

152 Furthermore, specific binding of rhAPC to human neutrophils via VLA-3

153 retic mobility shift assay revealed sequence-specific binding of rSaWRKY1 with MYB20 promoter.

154 from complex food samples as well as the non-specific binding of S-AuNPs.

155 ex cell-cell signaling networks that rely on specific binding of secreted ligands to cell surface rec

156 ), suggesting possible resilience to the non-specific binding of serum proteins.

157 Here, we present the structural basis for specific binding of Smad3 and Smad4 to GC-rich motifs in

158 A protein-lipid overlay assay showed specific binding of SVB to phosphatidylinositol 3,5-bisp

159 time measurements of the hierarchal promoter-specific binding of TFIID, TFIIA, and TFIIB.

160 These actions result from the specific binding of the antibody to the beta-subunit of

161 We report here that sequence-specific binding of the conserved Rbfox RRM to miRNA pre

162 Furthermore, through specific binding of the EVs to gold nanoparticle-conjuga

163 Flow cytometry analysis demonstrated specific binding of the IgG1 format to cells expressing

164 Structural studies demonstrate specific binding of the peptide to the pore of pentameri

165 rimarily at hotspots, determined by sequence-specific binding of the PRDM9 protein.

166 bset of genomic loci (hot spots) by sequence-specific binding of the PRDM9 protein.

167 ocking with unlabeled duramycin demonstrated specific binding of the radiotracer.

168 The specific binding of the target protein results in a chan

169 Specific binding of the three proteins to an Rsm-binding

170 me-activity curves, suggesting no off-target specific binding of the tracer in the healthy rat brain.

171 Specific binding of the tracer to MMP-12 was demonstrate

172 d receptor 6), apparently mediated by allele-specific binding of the transcription factor THRbeta (th

173 e TSPO protein expression to ligand binding, specific binding of the TSPO ligands 3H-PK11195 and 3H-P

174 We show that specific binding of these biomolecules can be reliably m

175 onic acid (APBA) to such vesicles results in specific binding of this reagent to some of the pendent

176 r role in complex disease and that cell type-specific binding of transcription factors (TF) is critic

177 studied the cellular expression of TSPO and specific binding of two TSPO targeting radioligands (3H-

178 ence-nuclear magnetic resonance demonstrated specific binding of UM101 to the computer-aided drug des

179 Here, we report the specific binding of zinc finger protein ZNF768 to the se

180 mation of any biomolecule or nanoentity upon specific binding on the surface of an acoustic wave devi

181 tput current is first observed upon antibody specific binding onto the organic semiconductor.

182 omponent of the cell dynactin complex), as a specific binding partner for E2.

183 (amplified in osteosarcomas) as a novel and specific binding partner of NKCC2.

184 functions, proteins must interact with their specific binding partners and often function as large as

185 Each TET protein also interacts with specific binding partners and partly plays their role in

186 Clearly distinct serum- and CPS-specific binding patterns and intensities were observed,

187 o histo-blood group antigens (HBGAs) and the specific binding patterns depend on the virus genotype.

188 Other mAbs had strain-specific binding patterns, with the majority of mAbs sho

189 Incorporation of specific binding peptide (His Pro Gln: HPQ) gives M13 ba

190 ot a mannopine-binding protein and reveals a specific binding pocket for DFG in SocA with an affinity

191 t the brightest readouts are attained when a specific binding pocket for the fluorophore is present o

192 new subfamily of lipolytic enzymes with the specific binding pocket located at the cap domain instea

193 , which anchors the inhibitor into a SULT1A3-specific binding pocket located outside the active site,

194 A1 is accommodated in a specific binding pocket that raises its pKa toward neutr

195 tivalent electrostatic interactions, without specific binding pockets or penetration into the lipid b

196 Furthermore, we found a strong and specific binding preference of Naa60 toward membranes co

197 Whereas TDRD3 has a structure-specific binding preference, it does not discriminate be

198 s dozens of motifs predicted to drive factor-specific binding profiles.

199 tion-for example, facilitating transient but specific binding, promoting allostery, or allowing effic

200 Guanidinium was chosen for its specific binding properties toward oxyanions: e.g., phos

201 n of a regularized and truly modular peptide-specific binding protein, based on designed armadillo re

202 harboring binding sites for the DNA sequence-specific binding protein, CENP-B.

203 rotein engineering tool for studying phospho-specific binding proteins and customizing their affinity

204 preselected repeats could be assembled into specific binding proteins on demand and thereby avoid th

205 Specific binding proteins, called readers, recognize the

206 window for (18)F-FE-PE2I and to validate the specific binding ratio (SBR) as a simplified quantificat

207 ase showed a loss of striatal [(123)I]FP-CIT-specific binding ratio compared with healthy controls (p

208 o validate the trapping of the molecules via specific binding reactions in the nanoledge cavities.

209 IL8 and TNFAIP2, we were unable to correlate specific binding sequences for GR or occupancy patterns

210 d to DNA non-specifically, and (ii) that non-specific binding shares common characteristics between v

211 c and selective binding to the KOR, and high specific binding signals.

212 lation of VDAC1 may be facilitated through a specific binding site at the functionally important Glu(

213 We find that spreading condensation from a specific binding site can take place in a path-independe

214 ted that loss of hyaluronan, which harbors a specific binding site for angiopoietin and a key regulat

215 at quercetin activates Sirt6 via the isoform-specific binding site for pyrrolo[1,2-a]quinoxalines.

216 Ligation by calcium at the PC-specific binding site II influences the active-site geom

217 nding of small-molecule "anchor" groups to a specific binding site of a target biopolymer.

218 mplex with a PAN RNA MRE, revealing a uracil specific binding site that is also conserved in KSHV.

219 Here, molecular docking is used to detect specific binding sites ("hot spots") for cholesterol on

220 TFs recognize short, but specific binding sites (TFBSs) that are located within t

221 d RCK2 domains move independently when their specific binding sites are occupied.

222 f alcohols on MscL gating arises not through specific binding sites but through a combination of the

223 The specific binding sites for acetylene are validated by mo

224 Modeling studies unveil the specific binding sites for acetylene capture as well as

225 mapping and mutagenesis analysis identified specific binding sites for hypoxia-inducible factors (HI

226 dy illustrates how mRNA junctions can create specific binding sites for interacting RNAs of prescribe

227 atty acid oxidation) and lack methylation at specific binding sites for transcription factors; 83% of

228 Nevertheless, specific binding sites have not been identified definiti

229 ental to its activity are recruited to Snail-specific binding sites is unclear.

230 Specific binding sites of Mg(2+) in folded conformations

231 abelled Cry1Ea, demonstrated the presence of specific binding sites on the midgut brush border membra

232 d discard' mechanism in which enhancers with specific binding sites promote rapid Cdk8-dependent Notc

233 NA using sliding and hopping to rapidly find specific binding sites, and then stalled to the specific

234 (HS), allowing PARP-1 to scan chromatin for specific binding sites.

235 extend occupancy across DNA regions far from specific binding sites.

236 bumin (BSA) was used for blocking of the non-specific binding sites.

237 esin turnover, which reloads it to cell-type-specific binding sites.

238 nding model to explain genome-wide cell-type-specific binding sites.

239 the polythiophene film and the nature of TNV specific binding sites.

240 replicative intermediate cRNA using several specific binding sites; however, the functions associate

241 ries of H2A.Z residues that form a chaperone-specific binding surface.

242 loosens cell walls (CWs) of grasses, but its specific binding target is unknown.

243 mics approach was applied to distinguish the specific binding targets from the non-specific ones.

244 To prevent non-specific binding the gold surface was treated with 3% BS

245 tute a family of bioactive compounds showing specific binding thermodynamics and following similar ph

246 3 mg/kg) dose-dependently reduced (11)C-EKAP-specific binding, thus demonstrating its binding specifi

247 lectivity from a mix of related agonists for specific binding to a GPCR.

248 PRC2 did not show sequence-specific binding to a region of high GC content (76%) de

249 their sizes and identify them based on their specific binding to antibodies.

250 , and Smu_63c amyloid from monomers, but non-specific binding to bacterial cells in the absence of am

251 n to improve its cancer targeting ability by specific binding to cancer cell over-expressed biotin re

252 and Congo red, were chosen because of their specific binding to cellulose and intrinsic fluorescence

253 t is a crucial determinant of high-affinity, specific binding to CG dinucleotide-containing RNA.

254 tion of the latter module revealed tight and specific binding to chitin, thereby unraveling a new fam

255 Specific binding to cMet was confirmed by cell staining,

256 titumor activity through tumor targeting and specific binding to cytotoxic T lymphocytes (CTLs).

257 Sequence-specific binding to DNA is crucial for targeting transcr

258 s are regulated by the FXRalpha2 isoform via specific binding to ER-2 motifs.

259 assessed the feasibility of applying allele-specific binding to filter potential regulatory single-n

260 appreciated DNA-binding domain that exhibits specific binding to G-quadruplex (G4) DNA structures.

261 Specific binding to GU-rich RNA strongly inhibited both

262 In vitro, [(11)C]MT107 showed specific binding to hCD80-positive tissue and high plasm

263 upled to chelators were developed displaying specific binding to human and murine FAP with a rapid an

264 Cytoadherence assays demonstrated specific binding to human spleen but not lung fibroblast

265 Specific binding to human thrombin as well as high stabi

266 bution of LacI in live cells, confirming its specific binding to lac operator regions on the chromoso

267 MaR1-specific binding to LGR6 was confirmed using 3H-labeled

268 , MBD2 does not show high affinity or methyl-specific binding to mCA.

269 ntial BTZ release in tumor-microenvironment, specific binding to MM cells, and an improved drug cellu

270 like territorial binding, prediction of site-specific binding to nucleic acids remains an unsolved ch

271 chemically distinct P2X7R ligand, indicating specific binding to P2X7R in the monkey brain.

272 Both [(11)C]-12 and [(18)F]-17 showed specific binding to PDE5 in myocardium of transgenic mic

273 After adjusting for non-specific binding to PEG-coated beads, the mean percent r

274 PSA-binding peptides exhibited specific binding to polymeric SA, as well as different d

275 in human serum for more than 6 h and showed specific binding to PSMA-expressing cells (concentration

276 Results: (99m)Tc-FAPI-19 showed specific binding to recombinant FAP-expressing cells wit

277 use of their high porosity and capability of specific binding to small molecules, thus underpinning a

278 ore than one zDABM sequence, whereas isoform-specific binding to the AR of zDHHC17 was identified for

279 n a high-avidity interaction that may confer specific binding to the Atg8-coated autophagosomal membr

280 viral capsid surface that alter the species-specific binding to the host receptor, transferrin recep

281 g, radiocaine proved to exhibit high in vivo specific binding to the myocardium of non-human primates

282 nscription factor (FgZC1), also required for specific binding to the nitrate reductase (NR) promoter,

283 nnot distinguish between signal arising from specific binding to the protein of interest and nonspeci

284 This study examines how site-specific binding to three identified neurosteroid-bindin

285 533 and EP-3612 were utilized to distinguish specific binding to tumour collagen from non-specific up

286 side effects, either through specific or non-specific binding to unintended membrane protein targets.

287 ity for importin alpha7 while preventing non-specific binding to viral RNA.

288 Although 12 and 13 showed displaceable and specific binding to Y(1)R in vitro and in vivo, the radi

289 The sensor was able to show specific binding towards the blood samples of infected p

290 In vitro, a dose-dependent specific binding was confirmed.

291 Specific binding was observed in many tissues, including

292 Non-specific binding was prevented by blocking free spaces o

293 Specific binding was shown in vitro, whereas fast metabo

294 Specific binding was tested in vivo with adrenalectomy a

295 No specific binding was, however, found on human progressiv

296 ading to a 50% reduction of (11)C-BMT-136088 specific binding were 73 +/- 30 nmol/kg and 28 +/- 12 nM

297 ), followed by (2) blocking the areas of non-specific binding with mercaptosuccinic acid.

298 hat none of the ampicillin aptamers show any specific binding with their intended target.

299 ose-dependent reduction of (18)F-PF-05270430 specific binding, with a half maximal effective concentr

300 is revealed the importance of minimizing non-specific binding within the relatively adhesive, 'sticky