ライフサイエンスコーパス: specific cytotoxicity

1 were highly correlated with increases in HIV-specific cytotoxicity.

2 TRAC) locus while maintaining potent antigen-specific cytotoxicity.

3 ne synapse formation, and, as a consequence, specific cytotoxicity.

4 work for endowing myeloid cells with antigen-specific cytotoxicity.

5 facilitates CAR T cell adhesion and antigen-specific cytotoxicity.

6 lonotypes, polyfunctionality, and potent SL9-specific cytotoxicity.

7 mma(+), and exhibited HLA-restricted CMVpp65-specific cytotoxicity.

8 , exhibit potent, HLA class I-restricted, GA-specific cytotoxicity.

9 effector mechanisms involved in reovirus 1/L-specific cytotoxicity.

10 l to undergo complement-independent antibody specific cytotoxicity.

11 eptide stimulation, possessed no ex vivo CMV-specific cytotoxicity.

12 the lines obtained were screened for peptide-specific cytotoxicity.

13 f stimulation further enhanced the levels of specific cytotoxicity.

14 d susceptible neonates acquired strong MT389-specific cytotoxicity.

15 g therapy (VDEPT) is its potential for tumor-specific cytotoxicity.

16 indicated that CD8(+) CTL mediated the pp65-specific cytotoxicity.

17 CEA-specific CD4+ responses and CEA peptide-specific cytotoxicity.

18 manner, coincident with restoration of viral-specific cytotoxicity.

19 d lymphocytes frequently lack detectable HIV-specific cytotoxicity.

20 type 2 CD8(+) T-cell subset with reduced EBV-specific cytotoxicity.

21 nhibited HCV RNA replication through antigen-specific cytotoxicity.

22 + T cells are primarily responsible for this specific cytotoxicity.

23 mor infiltrating T cells (T-TILs) lack tumor-specific cytotoxicity.

24 whereas antigen-pulsed APC strongly elicited specific cytotoxicity.

25 These CTLs from MM patients demonstrated specific cytotoxicity (24.7% at the effector-target [E/T

26 1)Tb]Tb-cAC10 demonstrated superior and CD30-specific cytotoxicity across a panel of T-cell lymphoma

27 We found that CD33 TEAMs mediated specific cytotoxicity across AML cell lines, including C

28 AZD0754 demonstrated potent and specific cytotoxicity against antigen-expressing cells i

29 tibodies to cell-bound MUC1 SEA domain exert specific cytotoxicity against cancer cells, and they poi

30 Dsg3 CAAR-T cells exhibit specific cytotoxicity against cells expressing anti-Dsg3

31 kinetics to Th1 cells in the spleen, mediate specific cytotoxicity against cells presenting pathogen-

32 ed that the resulting CTL cultures possessed specific cytotoxicity against EBV and CMV.

33 , IgG(8)-EXA and Mb(4)-EXA displayed potent, specific cytotoxicity against HER2-positive breast cance

34 tested in human primary NK cells and confers specific cytotoxicity against KIR/HLA-matched PSCA-posit

35 ation of GAB1 and demonstrated potent, tumor-specific cytotoxicity against MDA-MB-231 and T47D breast

36 T cells with specific cytotoxicity against peptides derived from the

37 nctional analysis of the T cell lines showed specific cytotoxicity against syngeneic porcine targets

38 eactivation, RNase A-NBC shows a significant specific cytotoxicity against tumor cells.

39 t targeting nfP2X7 showing potential antigen-specific cytotoxicity against twelve solid cancer types

40 In vitro, FL1-PNU exhibited potent and specific cytotoxicity against uPAR-expressing PDAC cell

41 z-huC825 T cells demonstrated potent antigen-specific cytotoxicity and cytokine release in vitro.

42 red with MVAp53, both adjuvants enhanced p53-specific cytotoxicity and demonstrated an additive effec

43 tivation, including how 4-1BB enhances tumor-specific cytotoxicity and how 4-1BB can promote tumor im

44 haracterized by CD8(+) T cell-mediated tumor-specific cytotoxicity and IFN-gamma production, and was

45 these SCID mice restored both, robust tumor-specific cytotoxicity and long-lived T-cell memory, capa

46 Gld and lpr mice demonstrated normal TMEV-specific cytotoxicity and maintained resistance to TMEV-

47 immunotoxin E9(Fv)-PE38 exhibits remarkably specific cytotoxicity and merits further evaluation for

48 gineered HSPCs produced T cells with antigen-specific cytotoxicity and near-complete lack of endogeno

49 ation with a strong correlation between cell-specific cytotoxicity and reciprocal coupling of drug-in

50 nes showed inverse relationships between EBV-specific cytotoxicity and secretion of IL-4, IL-10, and

51 Anti-Tn-MUC1 CAR T cells demonstrated target-specific cytotoxicity and successfully controlled tumor

52 s with tumor cells failed to induce idiotype-specific cytotoxicity, and following vaccination, deplet

53 Results: High biostability, MC1R-specific cytotoxicity, and high binding affinity were ob

54 ttributes that encompass even greater cancer-specific cytotoxicity, and provide strategies for tailor

55 re than one-third (13/36) demonstrated HIV-1-specific cytotoxicity, and this activity significantly c

56 lls to resist exogenously loaded peptide-MHC-specific cytotoxicity, as well as recognition in one-way

57 ase assays were used to evaluate ex vivo CMV-specific cytotoxicity associated with the PBMC samples.

58 inoma model was used to show that insulinoma-specific cytotoxicity can be accomplished by RIP coupled

59 totype to explore the effectiveness of tumor-specific cytotoxicity delivery using a receptor-mediated

60 ys were conducted, and the potential for non-specific cytotoxicity determined.

61 lls were enriched after 3 to 4 weeks and CMV-specific cytotoxicity developed 1 to 2 weeks later.

62 op1-DNA covalent adducts, can induce S-phase-specific cytotoxicity due to the arrest of progressing r

63 esponsible for down-regulating their antigen-specific cytotoxicity during both viral clearance and vi

64 Specific cytotoxicity, engraftment capability, and off-t

65 specificity on the MMP, often accompanied by specific cytotoxicity (enhanced over baseline toxicity).

66 s as a prodrug via a labile linker with site-specific cytotoxicity for cancer cells bearing these rec

67 ronegative (ES) individuals exhibiting HIV-1-specific cytotoxicity for the presence of HIV-1.

68 ow that the virus preparation exhibiting Fas-specific cytotoxicity has the same density as a retrovir

69 gamma(-/-) CD4 cells exhibit influenza virus-specific cytotoxicity; however, IFN-gamma-deficient CD4

70 e immunotherapy strategy to generate antigen-specific cytotoxicity in brain tumor patients.

71 ibody-drug conjugate (ADC), shows potent and specific cytotoxicity in DLK1-expressing neuroblastoma x

72 ne monoclonal antibody 13-1 possesses target-specific cytotoxicity in human PDA cell lines, we design

73 over years and broaden the spectrum of tumor-specific cytotoxicity in patients with melanoma.

74 (MYXV) that shows high efficiency for tumor-specific cytotoxicity in small-cell lung cancer (SCLC),

75 In this report, we demonstrate that the EBV-specific cytotoxicity in the BLCLpp65-primed culture had

76 tence and demyelination in this model, virus-specific cytotoxicity in the CNS of DA-resistant (B6 or

77 bits the generation of H-2K-restricted virus-specific cytotoxicity in the CNS, permitting a persisten

78 ested in vitro for biostability and for MC1R-specific cytotoxicity in uveal melanoma cells, and the l

79 alidated a CD1a-specific CAR with robust and specific cytotoxicity in vitro and antileukemic activity

80 ence of anti-donor Ab and Ab-dependent donor-specific cytotoxicity in vitro and intravascular IgM dep

81 lar to CD8(+) effector cells and showed CD20-specific cytotoxicity in vitro.

82 1 hosts exhibited a higher level of melanoma-specific cytotoxicity in vitro.

83 nsulinoma-specific expression and insulinoma-specific cytotoxicity in vitro.

84 g gamma interferon and exerting potent HIV-1-specific cytotoxicity in vitro.

85 cient DCs trigger Th1 differentiation and Ag-specific cytotoxicity in vivo.

86 and human neoplasms, in many instances tumor-specific cytotoxicity is not observed.

87 These results suggest that HIV-1-specific cytotoxicity of CD8(+) T cells is preferentiall

88 in C in transgenic tobacco plants and report specific cytotoxicity of celogentin C against a lung ade

89 In vitro, JNJ-64407564 induced specific cytotoxicity of GPRC5D+ cells with concomitant

90 Surprisingly, we show that the Ag-specific cytotoxicity of iNKT cells in vivo depended alm

91 erforin/granzyme-mediated mechanisms, the Ag-specific cytotoxicity of iNKT cells in vivo is largely r

92 antigen binding of anti-Tac pFv, and of the specific cytotoxicity of pFv-immunotoxin towards antigen

93 To overcome a non-specific cytotoxicity of STPP-L, we synthesized a novel

94 We determined that tumor-specific cytotoxicity of the poliovirus/rhinovirus chime

95 However, the non-specific cytotoxicity of these potent cytotoxins must be

96 The resulting CAR T cells demonstrate specific cytotoxicity of tumor cells comparable to that

97 ncer and healthy cells and explain the tumor-specific cytotoxicity of V-ATPase inhibition.

98 The purified IT showed specific cytotoxicity on nine different cancer cell line

99 Toxoplasma-infected APC stimulated specific cytotoxicity poorly or not at all, owing to dea

100 HIV-1-specific cytotoxicity remained detectable in most treate

101 ulation in establishing and sustaining tumor-specific cytotoxicity required for desirable immunothera

102 Of particular interest, Ks-restricted virus-specific cytotoxicity-restricted CTLs were identified in

103 8+ cytotoxic T cells (CTLs) enriched for HIV-specific cytotoxicity targeted against a diversity of HI

104 lly infected patients displayed less peptide-specific cytotoxicity than those from recovered patients

105 lded a functional toxin and showed cell line specific cytotoxicity that is consistent with heregulin

106 1)Cr release assays to measure ex vivo virus-specific cytotoxicity, the emerging virus-specific CTL r

107 includes cytokine effects and direct antigen-specific cytotoxicity to hematopoietic precursors.

108 Radiation therapy provides site-specific cytotoxicity to kill cancer cells but also has

109 tetramer (HLA-A2/MBP(111-119)) and exhibited specific cytotoxicity toward autologous target cells pul

110 Moreover, OK-DC displayed strong, specific cytotoxicity toward tumor cell targets.

111 Insulinoma-specific cytotoxicity using the suicide gene thymidine k

112 ing T(H)1 and T(H)2 cytokines, and may exert specific cytotoxicity via exocytosis of granulysin.

113 incubation with IL-12 for 5 to 7 days, HIV-1-specific cytotoxicity was augmented in a dose-dependent

114 L cells in 51Cr-release cytotoxicity assays, specific cytotoxicity was demonstrable using TILs from d

115 Detection of MC38-specific cytotoxicity was markedly enhanced when murine

116 tides were used to demonstrate that this CMV-specific cytotoxicity was specific for pp65.

117 A mechanism for this leukemia-specific cytotoxicity was suggested by the abnormal over

118 Alloantigen-specific cytotoxicity was tested using 51Cr release assa

119 death machinery to selectively deliver tumor-specific cytotoxicity (while minimizing damage to other

120 nity for FR-positive cells and to provide FR-specific cytotoxicity with an IC(50) in the low nanomola