ライフサイエンスコーパス: specific gene

1 Cacna1g, a down-regulated conduction system-specific gene.

2 sed in the brain and other organs, and brain-specific genes.

3 that included 9669 core genes and 7302 stage-specific genes.

4 able but seldom ascribed to mutations within specific genes.

5 rescue or promote phenotypes associated with specific genes.

6 n the training and to identify key cell type-specific genes.

7 rocess by directly activating and repressing specific genes.

8 and regulates expression of a subset of BAG-specific genes.

9 y benefit to maintaining strain diversity in specific genes.

10 ntial nascent expression (Bru-Seq) of neural-specific genes.

11 from transcript perturbations of monolignol specific genes.

12 holinos can be used to silence expression of specific genes.

13 expressed both CD4+ and CD8+ T cell lineage-specific genes.

14 but only three of these have been linked to specific genes.

15 dehydration tolerance may be impacted by sex-specific genes.

16 iption factor, which activates a set of Th17-specific genes.

17 eveals 5hmC enrichment in absorptive lineage-specific genes.

18 binding motifs in the promoters of cell type-specific genes.

19 ion techniques, we identified 157 bilaterian-specific genes.

20 six of which have been previously linked to specific genes.

21 erase chain reaction (qPCR), quantifies host-specific gene abundance in polluted water to identify an

22 rtance of heterochromatin organization for a specific gene activation program.

23 including 69 common genes and 225 cell-type-specific genes affected by THC administration, including

24 In addition, the expression of osteogenic specific genes alkaline phosphatase (ALP), Run-related t

25 PHI-base also curates literature describing specific gene alterations that did not affect the diseas

26 Our study reveals associations of specific gene alterations with different TIME types.

27 hniques, tissue ablation, microscopy, tissue-specific gene and enzyme activity expression with the an

28 are found to drive the expression of tissue-specific genes and change their tissue-specific expressi

29 are well documented and have been linked to specific genes and even individual nucleotides.

30 ntal duplications, we discovered new lineage-specific genes and expanded gene families that are poten

31 predict and provide experimental support for specific genes and molecular pathways driving Alzheimer'

32 cells, leading to derepression of non-muscle-specific genes and p16INK4a, a senescence driver encoded

33 ons vulnerable and resistant in AD, identify specific genes and pathways associated with AD neuropath

34 cyte-expressed genes, syndromal non-podocyte-specific genes and phenocopies with other underlying gen

35 rogression, including expression of podocyte-specific genes and podocyte morphology.

36 revealed an underrepresentation of podocyte-specific genes and proteins in late-stage disease.

37 ctor, BFD1 binds the promoters of many stage-specific genes and represents a counterpoint to the ApiA

38 ommitment requires the activation of lineage-specific genes and repression of alternative lineage gen

39 into biochemical signals, like activation of specific genes and signaling cascades that enable cells

40 and nine Citrus genomes revealed 605 species-specific genes and six rapidly evolving gene families in

41 d the firefly luciferase (luc) to competence-specific genes and spatiotemporally monitored the compet

42 ipulation tool to study mRNA modification of specific genes and their related biological functions.

43 itotic H3K27ac are associated with cell type-specific genes and their transcription factors for rapid

44 QTLs and their relationship to smooth muscle-specific genes and transcription factors.

45 ship between disease-associated variants and specific genes, and in particular their effect on risk c

46 tions have identified multiple genetic loci, specific genes, and specific variants increasing suscept

47 we still do not know how enhancers regulate specific genes, and we lack general rules to predict enh

48 Intriguingly, meiosis-specific genes are activated in C. neoformans and contri

49 ving these associations and their impacts on specific genes are largely unknown.

50 Lineage-specific genes are often interpreted as "novel" genes, r

51 in other benthic diatoms while many species-specific genes are strongly upregulated during sexual re

52 lutionarily related species, called "lineage-specific genes," are pervasive: Essentially every lineag

53 (2020) find that ARHGAP11B, a human-specific gene, augments cerebral cortex expansion by reg

54 causal roles for epigenetic modifications at specific genes because these techniques typically affect

55 In only a few cases has a specific gene been clearly identified.

56 single blind study using eight liver tissue-specific gene biomarkers (e.g. AMBP and AHSG) is highly

57 Specific gene biomarkers identify perceptible transcript

58 at 5hmC is preferentially enriched on tissue-specific gene bodies and enhancers.

59 rders associate with distinct sets of neuron-specific genes but converge onto shared loci within olig

60 es can efficiently trigger RNAi silencing of specific genes, but their therapeutic use has faced nume

61 of the protein encoded by the photoreceptor-specific gene C2orf71, which is mutated in inherited ret

62 es a simple way of identifying which lineage-specific genes call for special explanations beyond homo

63 These results also show that a specific gene can affect the distribution of tumor cells

64 New genes (or lineage-specific genes) can facilitate functional innovations.

65 These findings bridge levels to connect specific genes, cell classes, and biological pathways to

66 This study identifies sex- and age-specific gene changes in the mTORC1-activated lung mesen

67 Understanding the specific gene changes underlying the prodromic stages of

68 ork was modeled that identified both lineage-specific gene coexpression modules and modules conserved

69 We identified specific gene combinations that were associated with dis

70 Cdk9-dependence of antisense suppression at specific genes correlates with high H2Bub1 occupancy, an

71 largely due to a failure of up-regulation of specific genes critical for neuronal differentiation.

72 Renal collecting duct-specific gene deletion of CCN2 significantly reduced cys

73 Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA vi

74 In this context, SWI/SNF-specific gene deletion resulted in drug resistance.

75 syndrome in mice bearing the Asah1 podocyte-specific gene deletion.

76 Myeloid-specific gene-depletion studies confirmed that the prese

77 an alternative null hypothesis: that lineage-specific genes do have homologs outside of the lineage t

78 re, and perturbs transcription of hair cells specific genes during zebrafish development.

79 TCF binding sites are associated with cancer-specific gene dysregulation.

80 Here, we use a novel method of circuit-specific gene editing to show that the transcription fac

81 tential for each to be targeted using allele-specific gene-editing, RNAi, or small-molecule approache

82 ecent efforts to identify relatively "autism-specific" genes, efforts which focus on rare variants of

83 educed Pax6 and Tbr2 expression, both dorsal specific genes essential for cortical progenitor cell pr

84 pecific genes evolve slowest, whereas testis-specific genes evolve fastest).

85 hylation and evolution patterns (e.g., brain-specific genes evolve slowest, whereas testis-specific g

86 The sHSPs underwent a lineage-specific gene expansion, diversifying early in land plan

87 Comparative genomic analyses reveal specific gene expansions in the glycosyltransferase, cyt

88 pic, microscopic, transcriptomic, and tissue-specific gene expression analyses, we demonstrated that

89 Using an OSN-specific gene expression analysis, we explore downstream

90 RNA-seq (scRNA-seq) revolutionized cell type-specific gene expression analysis.

91 Rb-E2F/Dp1 pathways in regulating cell-cycle-specific gene expression and cell-cycle initiation.

92 developed a framework for integrating tissue-specific gene expression and epigenomic maps to obtain "

93 DTB-specific gene expression and function are directed by ci

94 have a significant role in regulating tissue-specific gene expression and transcript splicing.

95 e detect widespread differences in cell type-specific gene expression between subjects that are stabl

96 yses of caudate/putamen (striatal) cell type-specific gene expression changes in human HD and mouse m

97 n as a common feature associated with tissue-specific gene expression changes in the heart.

98 We found GPe PV(+) neuron-specific gene expression changes that suggested increase

99 s with histomorphological scores, identified specific gene expression changes using the invaluable re

100 ts were mapped onto human organs using organ-specific gene expression data.

101 nsive plasticity of cell types and cell-type-specific gene expression during organ evolution includin

102 ghlight the importance of studying cell type-specific gene expression dysregulation in HD pathogenesi

103 Information on molecular changes in cancer-specific gene expression facilitates efficient targeted

104 enerating differentiated hPSC-PCs with human-specific gene expression for modeling developmental and

105 challenge, revealing the importance of site-specific gene expression for robust host-microbial symbi

106 Recently, relaxed selection due to sex-specific gene expression has also been put forward to ex

107 in signaling cooperate to promote the dorsal-specific gene expression in amphioxus gastrula.

108 r layer of regulation to fine-tune condition-specific gene expression in animals and plants.

109 was aligned to differential patterns of cell-specific gene expression in the fetal cortex.

110 ivation of beta-catenin-driven and stem cell-specific gene expression in the presence of Apc (Min) or

111 ess variability in cell composition and cell-specific gene expression in the skin of patients with AD

112 Lineage-specific gene expression is modulated by a balance betwe

113 cis-regulatory architecture that governs PC-specific gene expression is not understood, and discrete

114 By contrast, cell-type-specific gene expression is stable across all tracheobro

115 aNp63 as a co-oncogenic driver of the cancer-specific gene expression milieu.

116 METH also elicited novel astrocyte-specific gene expression networks regulating responses t

117 We examine variation in this specific gene expression pattern across the whole brain,

118 ome specifications for dynamics that can map specific gene expression patterns in early development o

119 Our findings provide insights into cell-type-specific gene expression patterns in the developing huma

120 nd performed a computational search for cell-specific gene expression patterns.

121 ith ubiquitous, germline, and somatic tissue-specific gene expression patterns.

122 A specific gene expression profile, referred to as ECM3 (E

123 0.000542) and PDZK1IP1 (p = 0.0206) with RA-specific gene expression profiles and elevated expressio

124 Cell type-specific gene expression profiling of cortical pyramidal

125 havior in response to stress and use circuit-specific gene expression profiling to uncover novel down

126 al element regulates the inducible cell type-specific gene expression program of the human TNF/LT loc

127 Notch in squamous cells activates a context-specific gene expression program through lineage-specifi

128 cell, motile Pseudomonas aeruginosa induce a specific gene expression program.

129 e non-coding genome, leading to a senescence-specific gene expression program.

130 gulatory element evolution that shape tissue-specific gene expression programs and defines regulatory

131 cal/pathological signals link acetylation to specific gene expression programs and whether such respo

132 tors in feedforward loops to control lineage-specific gene expression programs during progressive dif

133 ted transcription factors coordinate subtype-specific gene expression programs in subtypes in which t

134 ive processes are modulated by regulation of specific gene expression programs.

135 tween cell types and contribute to cell-type-specific gene expression remains unclear.

136 Tissue-specific gene expression requires coordinated control of

137 nding TF decodes calcium signals to generate specific gene expression responses in plant cells via tr

138 In addition, an XBP1-specific gene expression signature is strongly associate

139 We also unmasked a retina-specific gene expression signature that might contribute

140 led the graduated acquisition of gut segment-specific gene expression signatures.

141 Resulting changes in muscle-specific gene expression that take place in dystrophin's

142 developmental stages and that maps cell-type-specific gene expression to specific anatomical domains.

143 tional genetic variants underlying cell type-specific gene expression variation.

144 distance from the root tip by repressing QC-specific gene expression via the ACR4/CLV1 receptors in

145 eveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usag

146 of information about the mechanisms of cell-specific gene expression, chromosome dynamics, protein l

147 lysis revealed a dramatic increase in tissue-specific gene expression, concurrent with slowed cycling

148 is associated with dopaminergic neuron (DaN)-specific gene expression, including mitochondrial functi

149 velopment significantly decreased hepatocyte-specific gene expression, liver size, and hepatocyte num

150 Given that ECs possess organ-specific gene expression, morphology, and function, we u

151 romoters is critically important to regulate specific gene expression, providing an additional layer

152 ed by marked decreases of both rod- and cone-specific gene expression.

153 al regulatory networks that define cell-type-specific gene expression.

154 l signaling pathways that orchestrate region-specific gene expression.

155 d gene) at many of these sites to drive vein-specific gene expression.

156 induced H3K9 trimethylation, ensuring tissue-specific gene expression.

157 is accompanied by the establishment of stage-specific gene expression.

158 player in the regulation of tissue and cell-specific gene expression.

159 ociation between PD risk and oligodendrocyte-specific gene expression.

160 tightly correlate with changes in cell type-specific gene expression.

161 tory modules responsible for ear- and tassel-specific gene expression.

162 olycomb protein required for spermatogenesis-specific gene expression.

163 the dynamics of genetic effects on cell type-specific gene expression.

164 tory networks control development via domain-specific gene expression.

165 category, such as tissue-enriched or tissue-specific gene expression.

166 of matrix-derived cues to regulate cell type-specific gene expression.

167 tanding the epigenetic regulation of haploid-specific gene expression.

168 ops to establish and reinforce the cell-type-specific gene-expression program; the ensemble of core T

169 sional organization of DNA to establish cell-specific gene-expression programs.

170 riation in microRNAs, which may regulate bat-specific gene-expression programs.

171 that the CAGE signature is not an aneuploidy-specific gene-expression signature but the result of nor

172 position abilities, the expression levels of specific gene families belonging to the glycoside hydrol

173 gs and found that they define a Brassicaceae-specific gene family that has expanded partly via multip

174 atula ferroportin Medicago truncatula nodule-specific gene Ferroportin2 (MtFPN2) is an iron-efflux pr

175 The follow-up pathway analysis from tissue-specific genes for asthma shows that the immune system p

176 on of stem rust resistance gene Sr60, a race-specific gene from diploid wheat Triticum monococcum L.

177 However, some EN subtype-specific genes from mice are expressed in completely dis

178 ay a key role in extending the repertoire of specific gene functions, including light and oxygen sens

179 Distinct missense mutations in a specific gene have been associated with different diseas

180 ke HIV or autoantibodies to IFN, variants in specific genes have been associated with severe varicell

181 Composite mutations are enriched in specific genes, have an elevated rate of use of less-com

182 to cell behaviors and function of WT and HM specific genes identified functional non-Smad pathways a

183 This novel function for Ambra1, and the specific genes impacted, may help to explain the wider r

184 between a single chromatin modification at a specific gene in a defined cell population and downstrea

185 tilage) has been identified as a chondrocyte-specific gene in the mouse.

186 neous and ATRA-induced activation of myeloid-specific genes in a manner correlated with myeloid diffe

187 r annotation improves detection of cell type-specific genes in both bulk and single cell RNA-seq data

188 ver, we also find that a minority of lineage-specific genes in both clades are not well explained by

189 We also sequenced specific genes in DNA from an external replication cohor

190 tected homologs of a large number of lineage-specific genes in fungi and insects.

191 hat will allow users to (i) test the role of specific genes in regulating various cellular processes,

192 HSPCs; this subset of genes constitutes "LSC-specific" genes in human AML.

193 ygotic genome activation (ZGA) genes (2-cell-specific genes) in pluripotent and differentiated cells,

194 the transcription of CArG box-dependent SMC-specific genes including SM22alpha, SMalpha-actin and SM

195 clinically, they do not have the benefit of specific gene-informed risk assessment and subsequent ma

196 ogy may allow the development of methods for specific gene insertion for precision genetic engineerin

197 ically influenced, but previous searches for specific genes involved have been underpowered.

198 either activate or repress transcription of specific genes involved in nickel homeostasis and acid a

199 d catabolism by repressing the expression of specific genes involved in TAG hydrolysis and fatty acid

200 odules (CRMs) that control the expression of specific genes is crucial for deciphering the logic of t

201 CBs associate with specific gene loci, which impacts expression and provide

202 We could find a specific gene marker for each metal in the 10-gene marke

203 a fibroblasts including a novel regeneration-specific gene, Mest.

204 It represents a powerful tool to achieve RGC-specific gene modulation, and also opens up a promising

205 teration could be involved in this cell type-specific gene modulation.

206 largely "hardwired" genome organization with specific genes moving small mean distances relative to s

207 Specific gene mutations also had an impact on the outcom

208 Specific gene mutations were too infrequent in patients

209 tiplex families to identify significant cell-specific gene network alterations in SCZ, these studies

210 ned by interaction counts within a phenotype-specific gene network, while the external degree distrib

211 g published datasets has verified that these specific gene networks are up regulated throughout the t

212 ntified evolutionarily conserved and species-specific gene networks controlling glial quiescence, rea

213 extensively benchmarked it to infer context-specific gene networks in 39 human tumor and 27 normal t

214 positions, as demonstrated for two neuronal-specific genes, Nnat and Mark3.

215 It is also shown that polymorphism in specific genes, NOTCH4 and CAT, is significantly correla

216 The induced leaf cells expressed M phase-specific genes of Arabidopsis encoding the mitotic kinas

217 a scenario where the expression profiles of specific genes of interest are concentrated in a small c

218 he hits identified in this analysis included specific genes of the ubiquitin proteasome system, and i

219 Development-specific genes often undergo DNA demethylation in their

220 nd combinatorial modifications of monolignol specific genes on lignin and other wood properties.

221 n annotations are statistically enriched for specific gene ontology categories.

222 g colonization and disease states, revealing specific genes/operons whereby Spn adapts to and influen

223 p wheat varieties of the future by exploring specific gene or chromosome regions and identifying germ

224 sms by which the different isoforms regulate specific genes or how the expression of these genes affe

225 ic factors, 36 of which involved analysis of specific genes or loci; aside from one meta-analysis, al

226 ighlight the potential importance of lineage-specific genes or protein motifs for understanding trait

227 regulation, yet little is known of cell type-specific gene pathways mediating adaptive learning.

228 between micropollutant biotransformation and specific gene products in complex microbial communities,

229 ase and the relationship of these changes to specific gene profiles and likely biologic activities oc

230 in cooperative regulation of a cardiomyocyte-specific gene program governing bioenergetic homeostasis

231 , the apoptotic metabolite secretome induced specific gene programs in healthy neighbouring cells, in

232 estions about how enhancers communicate with specific gene promoters and what molecular mechanisms un

233 direct, and efficient method for identifying specific gene regions affecting complex traits.

234 nto relevance of noncoding variants for cell-specific gene regulation and for disease association bey

235 our results indicate a rich layer of tissue-specific gene regulation at the level of alternative spl

236 for a role of TcUBP1 in trypomastigote stage-specific gene regulation important for T. cruzi virulenc

237 how these structures might relate to allele-specific gene regulation remain open.

238 binding of MEF2A and into its role in B cell-specific gene regulation.

239 ncers (SEs) play critical roles in cell type-specific gene regulation.

240 ditions is important to understand condition-specific gene regulation.

241 erned by developmental signals and cell-type-specific gene regulatory mechanisms.

242 ctor uses a computationally-inferred context-specific gene regulatory network and applies topological

243 chickens, cellular and global expression of specific genes related to the respective processes were

244 By contrast, cDC1-specific genes relied on AICE-dependent enhancers, which

245 fungi where a new transcriptional circuit (a-specific gene repression by the homeodomain protein Mata

246 ted genes as well as activation of hair cell-specific genes required for normal functional maturation

247 s to drive germline genes, including a mouse-specific gene set, and bear binding motifs for critical

248 A-seq analyses revealed sex- and development-specific gene sets along with those associated with the

249 anscriptional measurements demonstrated that specific gene sets-including those linked to low AR tran

250 ome fingerprints in plasma, including tissue-specific gene sets.

251 These mutant-specific genes showed consistent differential expression

252 q revealed hundreds of unique, dynamic organ-specific gene signatures depending on the microenvironme

253 luding cell proportions, reference cell type-specific gene signatures, or marker genes for each cell

254 cer and activator of transcription 3 (STAT3)-specific gene signatures.

255 OCR assays for metabolic features along with specific gene signatures.

256 We demonstrated that tissue-specific genes significantly reflected the tissue-releva

257 H3K27me3) mediates autosomal maternal allele-specific gene silencing and has an important role in imp

258 RNA interfering is a eukaryote-specific gene silencing by 20~23-nucleotide (nt) microRN

259 In vivo, nephrocyte-specific gene silencing of sns or c3g compromised nephro

260 the mosquito Aedes aegypti promotes sequence-specific gene silencing via the expression of two PIWI-i

261 ygotic and dizygotic twins was found for any specific gene, subgroup, or CHIP mutations overall, and

262 These coregulator-specific gene subsets often represent selected physiolog

263 ng the VMI system in the human cortex, where specific genes, such as TBR1, are likely to play a centr

264 ifically required only by a minority of cDC1-specific genes, such as Xcr1, which could distinguish be

265 teractive promoters-are enriched for lineage-specific genes, suggesting that interactions at these lo

266 ectly by gene therapy, if we can achieve RGC specific gene targeting.

267 ecular constructs to generate siRNAs against specific gene targets.

268 Data revealed fewer candidate CAM-specific genes than those recruited to function in C(4)

269 We identified 24 HM specific and 11 WT specific genes that are CP-related and/or involved in Tg

270 peripheral nervous system (PNS) and pinpoint specific genes that are major contributors to pain resil

271 disorders, it has been difficult to identify specific genes that moderate circuit functions to affect

272 The CNS-specific genes that regulate blood vessel morphogenesis

273 e in situ hybridization directly implicate Y-specific genes that respectively suppress female (pistil

274 and progress is being made in uncovering the specific genes that underlie these statistical associati

275 nriched for regulatory information of neuron-specific genes, that ASEs provide cell-specific regulato

276 s in the expression of thousands of germline-specific genes, the testis has the most diverse and comp

277 ortant to assess the need for and promise of specific gene therapies.

278 at the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly(A) tai

279 However, many eoRC patients lack PVs in RC-specific genes; thus, their genetic risk remains undefin

280 or cancer therapy, as it is able to identify specific genes to target at cancer cells without disrupt

281 ssumptions and estimate tissue- or cell-type-specific gene-to-trait effects.

282 yocardin (MYOCD), a master regulator for SMC-specific gene transcription by binding to SRF to form th

283 interact to form a complex that controls TE-specific gene transcription.

284 e and combinatorial knockdowns of monolignol specific gene transcripts influence the abundance of mon

285 In contrast, SMC-specific gene transfer of Prkcd accelerated reendothelia

286 architectures of germline and somatic tissue-specific genes, uncover regulatory rules for generating

287 be treated effectively by suppressing allele-specific genes using small interfering RNA (siRNA).

288 To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes a

289 levels of accuracy for mutation detection in specific genes were 98.6% for eis promoter and 100.0% fo

290 Several gland-specific genes were characteristic of different rhombome

291 Notably, a number of pollen-specific genes were lacking in Arabidopsis, and the numb

292 The putative CAM-specific genes were predominantly involved in night-time

293 Based on the gene array results, specific genes were selected for RT-qPCR evaluation usin

294 Oligodendrocyte- and neuron-specific genes were strongly overrepresented among genes

295 Finally, we identify specific genes where modification of uORFs likely repres

296 necessary and sufficient to activate lineage-specific genes while restricting the gene expression pro

297 anscriptome dataset, we identify melanoblast-specific genes whose expression contribute to metastatic

298 o detect and associate the E. coli serogroup-specific gene with major virulence genes and developed a

299 ial expression analysis identified cell type-specific genes with altered expression in alcoholics.

300 Through integrative analyses of those tissue-specific genes with large-scale genome-wide association