ライフサイエンスコーパス: specific inhibitor

1 occal disease in patients treated with an AP-specific inhibitor.

2 activity is controlled by calpastatin, their specific inhibitor.

3 of Gap19 peptide mimetic, a Cx43 hemichannel-specific inhibitor.

4 itional point of binding for a fungal enzyme-specific inhibitor.

5 signaling pathway by ruxolitinib, a JAK-STAT-specific inhibitor.

6 juxtamembrane region occurs in trans using a specific inhibitor.

7 or by inhibiting its kinase activity using a specific inhibitor.

8 ave built a pharmacophore model for a CYP3A4-specific inhibitor.

9 were decreased by omega-conotoxin, a Cav2.2-specific inhibitor.

10 ions were made with Ruxolitinib (Rux), a JAK-specific inhibitor.

11 e manner when combined with a Plasmodium PKG-specific inhibitor.

12 new transplant therapeutics, such as enzyme-specific inhibitors.

13 e is highly important for the development of specific inhibitors.

14 d-gain of function assays, and in vivo using specific inhibitors.

15 g pathways of IL-12 were determined by using specific inhibitors.

16 rest in the development of new efficient and specific inhibitors.

17 However, screens have yielded only a few specific inhibitors.

18 nositol 3-kinase inhibitors or PI3Kp110alpha-specific inhibitors.

19 e of MAB_4780 opens the way to identify such specific inhibitors.

20 o conflicting reports and lack of potent and specific inhibitors.

21 n delta-1 S268, which was reversible by mTOR-specific inhibitors.

22 proteasome system and ongoing development of specific inhibitors.

23 ar homeostasis as well as their targeting by specific inhibitors.

24 3K-Akt signaling pathways were studied using specific inhibitors.

25 the presence and absence of their respective specific inhibitors.

26 ifferent in cells treated with PBP2 and PBP3-specific inhibitors.

27 iling a new avenue for development of mTORC2-specific inhibitors.

28 ble efficacy and safety profile of this JAK3-specific inhibitor 11 led to its evaluation in several h

29 We found that the IRE1a-specific inhibitor 4mu8C could suppress the production o

30 However, the CREB specific inhibitor (666-15) diminished BDNF and GDNF pro

31 es simultaneously makes development of HDAC7 specific inhibitors a compelling objective.

32 Treatment with the Bcl-xL-specific inhibitor, A-1331852, reduces liver fibrosis, p

33 Thus, we deployed recently described specific inhibitors against all four of the neutrophil s

34 ar requirements for the design of potent and specific inhibitors against flaviviral proteins will con

35 outinely identify cyclic peptides as potent, specific inhibitors against proteins including PPI targe

36 re may explain the reduced potency of the GI-specific inhibitors against the GII protease and therefo

37 was also significantly inhibited by an AURKA specific inhibitor, alisertib (MLN8237).

38 est how tuning stereoelectronics can lead to specific inhibitor-allele pairs for the AAA superfamily.

39 inhibition of CARM1 activity with the CARM1-specific inhibitor AMI-1 significantly increased spine w

40 Starting with the bi-specific inhibitor, an alpha-helical peptide inhibitor w

41 Using Rac1-specific inhibitor and dominant-negative mutant N17Rac1,

42 n microscopy of TRPV5 in the presence of the specific inhibitor and its parent compound revealed nove

43 Using a PADI1-specific inhibitor and Padi1-morpholino knockdown, we fo

44 glomerular permeability; additionally, using specific inhibitors and activators of TRPC6, we showed t

45 Using specific inhibitors and gene knockdowns, we show that ac

46 ogesterone (P4)-induced AR by using a set of specific inhibitors and knock-out mice.

47 Using specific inhibitors and quantitative analysis at the sin

48 gned two classes of M2-S31N inhibitors, S31N-specific inhibitors and S31N/WT dual inhibitors, which a

49 Here, we describe the identification of TrkA-specific inhibitors and the structural basis for their s

50 Signaling study with specific inhibitors and Western blot analysis demonstrat

51 s was confirmed in co-culture by using their specific-inhibitors and exogenous recombinant-proteins.

52 Building on a bi-specific inhibitor approach targeting CD4 and gp41, a tr

53 ere is no CA-based therapy, highly potent CA-specific inhibitors are being developed as a new class o

54 ough multiple mechanisms, but as yet, no CAF-specific inhibitors are clinically available.

55 Studies with more potent and specific inhibitors are needed to establish any potentia

56 potential drug targets, but their potent and specific inhibitors are not available, and strategies fo

57 olymer conjugate (an iBody) containing a FAP-specific inhibitor as the targeting ligand.

58 binding site; inhibition of SREBP-1 by using specific inhibitors as well as small interfering RNA dec

59 cable for the development of other substrate-specific inhibitors as well.

60 s to CC in vitro using recombinant proteins, specific inhibitors, as well as deficient and normal ser

61 y kinetic analysis, combined with the use of specific inhibitors at defined time intervals.

62 TOPK knocking down, or HI-TOPK-032 (TOPK specific inhibitor) attenuated colony formation and cell

63 broblasts (MEFs), inhibition of HSP90 by its specific inhibitor AUY922 promoted the accumulation of u

64 Targeting SMYD2 with its specific inhibitor, AZ505, delayed cyst growth in both e

65 olino, as well as inhibition of Smyd2 by its specific inhibitor, AZ505, led to increased protective p

66 (GSC) xenograft model resistant to the PI3K-specific inhibitor BKM-120.

67 ng and blockage of the GABAA receptor by the specific inhibitors both significantly impaired arboviru

68 Blockade of NKCC1 after SE with the specific inhibitor bumetanide restored NKCC1 and KCC2 ex

69 egulation of Skp2 or treatment with the Skp2-specific inhibitor C1 revealed that Skp2 drives prolifer

70 hese findings suggest that transamidase site-specific inhibitors can inhibit GTP binding/signalling b

71 A PI3Kdelta-specific inhibitor, compound GS-649443, that has superio

72 e addition of human serum albumin to the tri-specific inhibitor could allow it to function as a long-

73 t chemically perturbing Fus3 dynamics with a specific inhibitor could effectively redirect the mating

74 Our data also suggest that BMI1-specific inhibitors could be an effective treatment of C

75 Importantly, the PDGFR-specific inhibitor crenolanib significantly reduced intr

76 This effect was abrogated by the PDGFRalpha-specific inhibitor crenolanib.

77 sion and cell migration, whereas a miR-95-3p specific inhibitor decreased cell proliferation, cell cy

78 phospho-site mutation and treatment with CK2 specific inhibitors demonstrated that phosphorylation at

79 ed here provide a blueprint for discovery of specific inhibitors designed to prevent parasite infecti

80 Inhibition of CAMKIIgamma with a specific inhibitor destabilized c-Myc and reduced tumor

81 Given the importance of specific inhibitor development, it is crucial to underst

82 nd following acute treatment with the flavin-specific inhibitor diphenyleneiodonium in wild-type flie

83 ARS-1620 (G12C-specific inhibitor) disrupts the KRAS(G12C)-AGO2 interac

84 ubstitute AMP1 in planta and that an HsGCPII-specific inhibitor does not evoke amp1-specific phenotyp

85 a highly selective PI3K (PI3Kdelta) isoform-specific inhibitor effective in relapsed/refractory CLL

86 the isocitrate dehydrogenase 2 (IDH2) mutant-specific inhibitor enasidenib, leading to improved quali

87 adaptation, with both nonselective and HDAC8-specific inhibitors enhancing the durability of BRAF inh

88 from the covalent binding of the proteasome-specific inhibitor epoxomicin to BPH.

89 Moreover, the Epac-specific inhibitor ESI-09 inhibits established CFA-induc

90 armacologic inhibition of Epac1 with an Epac specific inhibitor, ESI-09, phenocopied the effects of E

91 specific inhibitor MC1568, but not the SIRT1 specific inhibitor EX-527.

92 The goal of this project was to identify a specific inhibitor for alpha(D)beta(2)-CEP interaction t

93 Our goal is to develop a TGK-specific inhibitor for coadministration with ascofuranon

94 FOXH1 expression is also stimulated by a specific inhibitor for H3K79 methyltransferase DOT1L (iD

95 travenously administration of importazole, a specific inhibitor for KPNB1, effectively reduced PCa tu

96 hibited in PK-15 cells treated with U0126, a specific inhibitor for MEK1/2/ERK1/2, whereas MEK2 did n

97 We used this cocktail to develop specific inhibitors for beta1c, beta2c, beta5c, and beta

98 Specific inhibitors for ERK1/2 MAPK (PD98059), p38 MAPK

99 The lack of potent/specific inhibitors for H(2) S-producing enzymes contrib

100 ive of approaches to develop IRAK1- or IRAK4-specific inhibitors for potential therapeutic applicatio

101 C1/2 kinase inhibitors and developing mTORC2-specific inhibitors for use in this setting.

102 t study, we exploited a lung epithelial cell-specific inhibitor [Formula: see text] kinase 2 (IKK2) k

103 s have brought to light that the G(q) family-specific inhibitor FR900359 (FR) is unexpectedly efficac

104 show that a novel, brain-permeable p110beta-specific inhibitor, GSK2702926A, ameliorates FXS-associa

105 PT2385, a HIF-2alpha-specific inhibitor, had preventive and therapeutic effec

106 of EPRS using a PRS (prolyl-tRNA synthetase)-specific inhibitor, halofuginone, significantly decrease

107 ttractive target for cancer therapy, but few specific inhibitors have been found.

108 However, the lack of specific inhibitors hinders the study of TRPM2 in brain

109 and exceeded cell killing by the PI3K-delta-specific inhibitor idelalisib.

110 tion of P300 acetyltransferase activity by a specific inhibitor improves insulin sensitivity and decr

111 ancy was assessed using celecoxib as a COX-2 specific inhibitor in a murine model of OSA bearing Lewi

112 nes acting as a new class of bacterial betaG-specific inhibitors in a pH-dependent manner.

113 nciple for the clinical development of EP300-specific inhibitors in FL and DLBCL.

114 ion is primarily handled by SGLT2, and SGLT2-specific inhibitors, including dapagliflozin, canagliflo

115 tly controlled by a limited number of tissue-specific inhibitors, including SPINK6, an inhibitor of t

116 sm by talarozole, a cytochrome P450 (CYP) 26 specific inhibitor, increased the effects ofatRA on mito

117 rlaps with the pocket occupied by some H3 HA-specific inhibitors, indicating the high relevance of th

118 se 2 (JAK2)/STAT3 and TGF-beta1 signaling by specific inhibitors inhibited BMF-induced sphere formati

119 However, recent entry of pathway-specific inhibitors into the clinic reveals mixed patien

120 ebsiella pneumoniae carbapenemases (KPC), no specific inhibitor is available for the phenotypic detec

121 that TRPC4 is expressed in human DRGs and a specific inhibitor is in clinical trials, our data not o

122 and ex vivo data, we show that a Loop 1 GUS-specific inhibitor is not capable of reducing the develo

123 2-like signature downregulated by which MAGL-specific inhibitor, JZL184, increased survival rate sign

124 ide hydroxamic acid (SAHA) and a novel HDAC6-specific inhibitor (KA1010) in models of alloreactivity.

125 dium phosphatidylinositol-4-OH kinase (PI4K)-specific inhibitor KDU691.

126 The sAC-specific inhibitor KH7 not only reversed sensitization t

127 Treating myoblasts with the proteasome-specific inhibitor lactacystin impeded myoblast differen

128 Our studies demonstrate that HDAC8-specific inhibitors limit the adaptation of melanoma cel

129 The roles of ferroptosis-specific inhibitor, liproxastin-1 (Lip-1), and ACSL4 mod

130 The specific inhibitor (Ly294002) of PI3K/AKT pathway signif

131 chaperones in P. falciparum biology and how specific inhibitors may assist us in disentangling their

132 ne diseases, in which development of isozyme-specific inhibitors may be useful for treatment.

133 Paralog-specific inhibitors may lead to drugs with fewer side ef

134 rved after administration of HDACs class IIa specific inhibitor MC1568, but not the SIRT1 specific in

135 -deficient or WT mice treated with the NLRP3-specific inhibitor MCC950.

136 ithelial cell lines incubated with the DNM1L-specific inhibitor Mdivi-1.

137 s G121-treated human DCs was blocked by TLR8-specific inhibitors, mediated by L lactis G121 RNA, and

138 itutively active) Akt and reduced by the Akt-specific inhibitor MK2206.

139 Here, we report that an IRE1alpha RNase-specific inhibitor, MKC8866, strongly inhibits prostate

140 genetic knockdown or co-treatment with TBK1-specific inhibitor (MRT67307).

141 lung-specific inhibition of iNOS with a iNOS-specific inhibitor, N6-(1-iminoethyl)-L-lysine, dihydroc

142 on and tested the utility of two novel KDM1A-specific inhibitors (NCL-1 and NCD-38) to promote differ

143 COX-1/2 inhibitor indomethacin and the COX-2-specific inhibitors NS-398 and celecoxib or siRNAs targe

144 or survival of Tmem in chronic infection, a specific inhibitor of acetyl CoA carboxylase 1, 5-(tetra

145 G(0)/G(1) switch gene 2 (G0S2) is a specific inhibitor of adipose triglyceride lipase (ATGL)

146 tly abrogated in the presence of PD146176, a specific inhibitor of ALOX15.

147 stration of low-dose carboxyatractyloside, a specific inhibitor of ANT.

148 ification of BRD-7880 as a potent and highly specific inhibitor of aurora kinases B and C.

149 , our results strongly suggest that LF3 is a specific inhibitor of canonical Wnt signaling with antic

150 ar properties, thus questioning its use as a specific inhibitor of cargo recognition by the AP-2 adap

151 and colleagues report that a newly developed specific inhibitor of CDK12/13, SR-4835, sensitizes trip

152 ither with Ser-to-Ala substitution or with a specific inhibitor of CDK4/6 kinase blocked Her4-induced

153 ell cycle regulator of NHEJ) is a cell-cycle-specific inhibitor of cNHEJ.

154 balamin and is inhibited by propyl iodide, a specific inhibitor of cobalamin-dependent enzymes.

155 2,3-dioxygenase (IDO), but not by NSC-398, a specific inhibitor of COX-2, suggesting IDO as a mediato

156 ipumps were used to infuse intracerebrally a specific inhibitor of depolarizing GABAergic transmissio

157 ce with tauroursodeoxycholic acid (TUDCA), a specific inhibitor of ER stress.

158 A specific inhibitor of extracellular PPIA, MM218, given a

159 we demonstrate that ferrostatin-1 (Fer-1), a specific inhibitor of ferroptosis, decreases the level o

160 We propose that identification of a specific inhibitor of HR in Plasmodium may enable invest

161 y pretreatment with 1-methyl-D-tryptophan, a specific inhibitor of indoleamine-pyrrole 2,3-dioxygenas

162 F4G-eIF3 interactions converted eIF4E into a specific inhibitor of initiation on capped mRNAs.

163 Guselkumab, a specific inhibitor of interleukin-23 (IL-23) via IL-23 p

164 beneficial therapeutic effect of AZD1480, a specific inhibitor of JAK1/2, in suppressing neuroinflam

165 of the oxazolidinone GSK180 as a potent and specific inhibitor of KMO.

166 e, the pharmacological activity of JPH203, a specific inhibitor of LAT1, was studied in bladder cance

167 As a specific inhibitor of Lp-PLA2, darapladib has been shown

168 f3 expression in cells treated with a highly specific inhibitor of LRRK2 protein kinase activity.

169 A specific inhibitor of MDA-9/Syntenin activity, PDZ1i (11

170 l genetics approach by screening for a stage-specific inhibitor of morphological development from mic

171 sue, we examined the effects of rapamycin, a specific inhibitor of mTOR, on B cell and CD4 T cell res

172 ell accumulation were reversed by IDH-C35, a specific inhibitor of mutant IDH1.

173 Ouabain (10 mumol l(-1)), a specific inhibitor of Na/K-ATPase, abolished dopamine-in

174 somes and inhibiting the inflammasome with a specific inhibitor of NOD-, LRR-, and pyrin domain-conta

175 tic approaches involving the use of ES936, a specific inhibitor of NQO1 and siRNA and gene transfecti

176 Thus, combined treatment between a specific inhibitor of PGM3, named FR054, and GEM results

177 ticular chondrocytes, in vitro, with IOX2, a specific inhibitor of PHD2, promoted articular chondrocy

178 of zeta inhibitory peptide (ZIP), a supposed specific inhibitor of PKMzeta that interferes with both

179 Genipin is increasingly applied as a specific inhibitor of proton transport mediated by mitoc

180 Fatostatin was recently discovered as a specific inhibitor of SREBP cleavage-activating protein

181 Previous studies identified perchlorate as a specific inhibitor of SRM.

182 t the addition of 500 ppm lactisole, a human-specific inhibitor of STRs.

183 t regulates H3K9me3 (using a newly developed specific inhibitor of SUV39H1), it is possible to alter

184 ection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2

185 alkaloid paxilline (PAX) is a commonly used specific inhibitor of the large-conductance, voltage- an

186 DH in IPF and the therapeutic potential of a specific inhibitor of this enzyme in a mouse model and h

187 circulating levels of Dickkopf-1 (DKK-1), a specific inhibitor of this pathway, are altered in patie

188 A specific inhibitor of USP14, IU1, reversed HIV-1 latency

189 of partial pressure of CO2 Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase that blo

190 rphan multi-span transmembrane protein, as a specific inhibitor of Wnt/FZD signaling.

191 on have impaired the development of allergen-specific inhibitors of allergic responses.

192 ouse B-cell line CH12F3 and a combination of specific inhibitors of APE1's redox (APX3330) and repair

193 a and IL-18 secretions, which are reduced by specific inhibitors of caspase activation (Q-VD) and NLR

194 Specific inhibitors of COX-2 and 5-LOX decreased formati

195 ibitors as well as prioritize novel, context-specific inhibitors of difficult targets, such as MYC an

196 Specific inhibitors of focal adhesion kinase (FAK) block

197 lades B4 and B1 and should help in designing specific inhibitors of gelatin degradation.

198 eded for therapy, but development of potent, specific inhibitors of GGT1 has been hampered by a lack

199 tions allowed the identification of cofactor-specific inhibitors of InhA that do not require activati

200 hippocampal slices from adult rats and used specific inhibitors of kinases and calcium sources.

201 n B lymphocytes latently infected with KSHV, specific inhibitors of KSHV miR-K9 led to increased GADD

202 t surface display technique to obtain highly specific inhibitors of MMP-14 by modifying the natural n

203 oited therapeutically through development of specific inhibitors of MUS81 nuclease activity.

204 evasion in IDH-MUT gliomas and suggest that specific inhibitors of mutant IDH may improve the effica

205 Macropinocytosis was confirmed using specific inhibitors of PI3K and actin polymerization.

206 microRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene express

207 ion in Kit 225 T cells could be blocked with specific inhibitors of RAS, EPAC, RAP1, RAF1, ADCY6, and

208 both disease initiation and progression, and specific inhibitors of selected PI3K p110 isoforms for m

209 Na(+)-coupled glucose transporter SGLT2, and specific inhibitors of SGLT2 are now available to patien

210 Our findings suggest that parasite-specific inhibitors of SUMOylation could be developed an

211 potential target for development of parasite-specific inhibitors of SUMOylation.

212 and these can be exploited for the design of specific inhibitors of T4SS function.

213 pment of new therapeutic strategies based on specific inhibitors of the coxsackievirus B proteinase 2

214 Using specific inhibitors of the enzyme that installs O-GlcNAc

215 Specific inhibitors of the glutamine pathway led to decr

216 es YM-254890 and FR900359 are the only known specific inhibitors of the Gq subfamily of G proteins; h

217 To this end, we have constructed isoform-specific inhibitors of the human cytosolic sulfotransfer

218 mportant implications for efforts to develop specific inhibitors of the RPN2-RPN13 interaction, and s

219 The design of potent and specific inhibitors of this enzyme will be essential to

220 en-activated protein kinase pathway, whereas specific inhibitors of this pathway reduced macrophage p

221 yl)phenol compounds described by Kategaya as specific inhibitors of USP7.

222 that breast tumors treated with a p110alpha-specific inhibitor often circumvent inhibition and resum

223 d by directly inhibiting its activity with a specific inhibitor or/and by preventing its maturation.

224 reatment with a pan-HDAC inhibitor, an HDAC6-specific inhibitor, or depletion of HDAC6, suggesting th

225 cked deacetylation of ac-SMC3 using an HDAC8-specific inhibitor PCI-34051 in MCF7 breast cancer cells

226 ne deacetylase 8 (HDAC8) by either the HDAC8-specific inhibitor PCI-34051 or small interference (si)R

227 Blockade of S6K1 by a specific inhibitor PF-4708671 synergistically enhanced t

228 /Tau) mutant SCN treated with the CK1epsilon-specific inhibitor PF-4800567 (3-[(3-Chlorophenoxy)methy

229 IL-1beta stimulation compared to FAK or Src specific inhibitors (PF-228 or Dasatinib), which inhibit

230 The p53-specific inhibitor pifithrin-alpha (PFT-alpha) significa

231 PI4KA-specific inhibitors promote replication of unadapted vir

232 nt on reversible binding of glucokinase to a specific inhibitor protein, glucokinase regulatory prote

233 rect inhibition of mutant RAS through allele-specific inhibitors provides the best therapeutic approa

234 m that allows cancer cells to evade oncogene-specific inhibitors, providing a rationale to cotarget E

235 epletion of Axl using CRISPR/Cas9 and an Axl-specific inhibitor R428 suppress vitreous-induced Akt ac

236 analysis of rice cells treated with the TOR-specific inhibitor rapamycin revealed that TOR not only

237 or AZD8055, in contrast to allosteric mTORC1-specific inhibitor rapamycin, strongly inhibited 4E-BP1

238 Although its specific inhibitor, rapamycin, is currently used as an i

239 er, we were surprised that transamidase site-specific inhibitors reduce cancer stem cell survival.

240 inhibition of ERK1/2 phosphorylation with a specific inhibitor reduced the activation of ROCK1.

241 ivation and cells treated with these pathway-specific inhibitors reduced Xbp1 splicing, suggesting a

242 ockdown of PRMT5 or inhibition of PRMT5 by a specific inhibitor reduces the expression of AR and supp

243 over the past several decades, however, RAS-specific inhibitors remain elusive.

244 In summary, treatment with DGAT1 or DGAT2 specific inhibitors resulted in different responses on l

245 However, targeting FcRn with specific inhibitors results in reduction in only IgG lev

246 nhibition of topoisomerase II activity using specific inhibitors revealed quite dramatic effect on co

247 kappaB (either by Rosiglitazone or NF-kappaB specific inhibitor), revealing a new role for NF-kappaB

248 A novel RhoA-specific inhibitor, Rhosin, was used to inhibit RhoA act

249 )H]uridine uptake in the presence of the ENT-specific inhibitor S-(4-nitrobenzyl)-6-thioinosine (NBMP

250 type mouse or human platelets with the Vps34-specific inhibitors, SAR405 and VPS34-IN1, induced abnor

251 Blockade of the TGF-beta pathway with the specific inhibitor SB431542 and via SMAD-3 siRNA prevent

252 We propose that development of CARM1-specific inhibitors should focus on its N-terminus and p

253 Blockade of p75 cleavage using a specific inhibitor significantly improves migration and

254 kade of JAK2/STAT3 and TGF-beta signaling by specific inhibitors significantly inhibited cell prolife

255 EPHA2-specific inhibitors similarly enhanced the therapeutic a

256 an effect that was reversed by the sirtuin 1-specific inhibitor sirtinol.

257 in vitro synergistic effects between the SK1-specific inhibitor SK1-I and standard chemotherapeutics,

258 onversely, SphK1 inhibition with the isotype-specific inhibitor SK1-I in WT cells induced accumulatio

259 ortantly, disruption of JNK signaling with a specific inhibitor (SP600125) or knockdown technology (L

260 alpha using a clinically relevant and highly specific inhibitor successfully treated iron overload in

261 Inhibition of either signaling pathway with specific inhibitor suppressed T63-induced RUNX2 expressi

262 dies were aimed at determining how XEN445, a specific inhibitor targeting LIPG phospholipase activity

263 eural signaling, either using nonspecific or specific inhibitors targeting the TRPV4/adenosine tripho

264 information may also aid efforts to develop specific inhibitors targeting this essential viral enzym

265 modulin-dependent protein kinase II (CaMKII) specific inhibitor tatCN21 peptide.

266 ed many SCF ligases, or conversely, a highly specific inhibitor that discriminated between even the c

267 using dapansutrile (OLT1177), an oral NLRP3-specific inhibitor that is safe in humans.

268 vel insights into the potent bacterial betaG-specific inhibitor that would allow this inhibitor to be

269 ge response, and highlight the rapid rise of specific inhibitors that are now in clinical trials for

270 an increased interest in the development of specific inhibitors that can provide potential novel pha

271 ic regulators identified several bromodomain-specific inhibitors that promote differentiation and ena

272 Cancer-specific inhibitors that reflect the unique metabolic ne

273 a disintegrin and metalloproteinase, with a specific inhibitor TMI-1 or by shRNA knockdown prevented

274 Using specific inhibitors to block SLC1A5 and CD98 function, w

275 d assessed the potential use of PI3K isoform-specific inhibitors to favorably condition CD8(+) T cell

276 ted exclusively mTORC1 due to the paucity of specific inhibitors to S6K1.

277 MSCs were treated with specific inhibitors to suppress PGE2 secretion, and prol

278 nesulphonamide (H89) is often used as a "PKA specific inhibitor" to study the involvement of PKA in s

279 d that can be explored to produce potent and specific inhibitors towards VRK1 and VRK2.

280 bolism and inhibited glycolysis, while MPC-1-specific inhibitor UK5099 attenuated these effects.

281 deliver an overview of the current state of specific inhibitors used in the treatment of allergy, wi

282 sistance and paves the way for the design of specific inhibitors useful in reversing antibiotic resis

283 e extended our efforts to identify PI3Kalpha-specific inhibitors using PI3Kalpha crystal structures t

284 enzymatic dead version of PRMT5 and a PRMT5-specific inhibitor, we demonstrated the requirement of t

285 Using specific inhibitors, we demonstrated that both steps wer

286 Using specific inhibitors, we find that nuclear movement and a

287 Using DREAM-null platelets and PI3K isoform-specific inhibitors, we observed that platelet DREAM is

288 Because ADAM prodomains can act as specific inhibitors, we postulate a role for meprin beta

289 By using genetically modified stem cells and specific inhibitors, we show that embryogenesis of ESC-

290 Using specific inhibitors, we showed that CCHFV NSs induces ap

291 entification of the first orally active JAK3 specific inhibitor, which achieves JAK isoform specifici

292 These specific inhibitors, which are active in cell culture mo

293 These exquisitely specific inhibitors will facilitate the dissection of Ep

294 stoyl lysine compound, TM, as a potent SIRT2-specific inhibitor with a broad anticancer effect in var

295 lung cancer, coadministration of a PI3Kdelta-specific inhibitor with a tumor-specific vaccine decreas

296 data present the first neutrophil exocytosis-specific inhibitor with in vivo anti-inflammatory activi

297 Together, these findings indicate that specific inhibitors with the ability to block pathologic

298 nt in the family of PHDK enzymes and a PDHK1 specific inhibitor would therefore have anti-cancer acti

299 izes Snail1 by inducing Dub3 expression, the specific inhibitor WP1130 binds to Dub3 and inhibits the

300 hat this could be antagonized with the Cat L-specific inhibitor Z-FY-CHO.