ライフサイエンスコーパス: specific pathogen-free

1 rm-free SAMP1/Fc mice examined compared with specific pathogen-free AKR control mice of similar age.

2 we find a large novel subpopulation in both specific pathogen-free and germ-free mice that has not b

3 ometry data from CD8(+) T cells derived from specific pathogen-free and germ-free mice, and stratify

4 as performed on skin from neonatal and adult specific pathogen-free and germ-free mice.

5 Importantly, we used both antibiotic-treated specific pathogen-free and germ-free rederived mice with

6 n IECs to LC isolated from mice bred in both specific pathogen-free and germfree conditions also resu

7 Young adult specific-pathogen-free and germ-free mice were used to d

8 ion worsened autoimmune manifestations under specific-pathogen-free and gnotobiotic conditions, notab

9 and hippocampus derived from germ-free (GF), specific pathogen free, and colonized-GF mice.

10 unctionally compared between germ-free (GF), specific pathogen-free, and GF mice reconstituted with m

11 ntestinal inflammation when maintained under specific pathogen-free animal facility conditions.

12 r three distinct environmental conditions: a specific pathogen-free animal room (SPF), a general anim

13 ies in mice are typically performed in naive specific pathogen-free animals responding to their very

14 onalized with the microbiome from wild-type, specific pathogen-free animals.

15 ittaci B577 antisera, but not with sera from specific-pathogen-free animals.

16 inDelta850/+;Il10-/- or ApcMinDelta850/+ and specific pathogen-free ApcMinDelta716/+ mice).

17 nounced for wheat and soy and occurred under specific pathogen-free as well as germ-free housing cond

18 and colonic lamina propria was determined in specific pathogen-free B6 and TCR transgenic animals, as

19 .hCD46Tg) pig cardiac xenografts survival in specific pathogen free baboons.

20 pared with littermates conventionalized with specific pathogen-free bacteria.

21 ion by Listeria monocytogenes in susceptible specific pathogen-free BALB/c mice.

22 E- and P-selectin (E(-/-)P(-/-)) kept under specific pathogen-free barrier conditions have high circ

23 In this study, when mice housed in a rodent, specific pathogen-free barrier room were challenged with

24 Sixteen specific-pathogen-free beagles were infected with Borrel

25 Twenty 6-week-old specific-pathogen-free beagles were infected with Borrel

26 Eighteen 12-week-old specific pathogen-free cats, blood culture- and serum an

27 Eighteen adult specific pathogen-free cats, vaccinated against FHV-1 se

28 nic infection following blood transfusion in specific-pathogen-free cats and that Bartonella DNA can

29 of the peripheral blood, and of the serum of specific-pathogen-free cats during the acute phase of FI

30 Two-week-old specific-pathogen-free cats infected with FIV-C36 tissue

31 None of the six age- and sex-matched specific-pathogen-free cats inoculated with only T. gond

32 Two groups of four specific-pathogen-free cats were exposed to PLV via the

33 Eighteen specific-pathogen-free cats were inoculated with Bartone

34 nfectivity and pathogenesis, six young adult specific-pathogen-free cats were inoculated with cell-fr

35 d FIP when inoculated intraperitoneally into specific-pathogen-free cats.

36 of 60 healthy, domestic (sexually intact and specific pathogen-free) cats maintained under strictly c

37 Specific pathogen-free chickens inoculated with the reco

38 When specific-pathogen-free chickens were exposed to a pathog

39 Eighty-five 60-week-old specific-pathogen-free chickens were randomly divided in

40 Vaccination of specific-pathogen-free chickens with M41-R induced 100%

41 Vaccination of specific-pathogen-free chickens with these recombinant v

42 7A PT 8 in birds from vaccinated hens and in specific-pathogen-free chickens.

43 ree HA subgroups replicated restrictively in specific-pathogen-free chickens.

44 a strain which prevents the colonization of specific-pathogen-free chicks by Clostridium perfringens

45 ional colony, IgG-mediated passive SA in our specific pathogen-free colony mice depended considerably

46 al models including germ-free (no microbes), specific-pathogen-free (complete gut microbiota) and spe

47 and their wild-type littermates reared under specific pathogen-free condition with aging.

48 This inflammatory disorder occurs under specific pathogen-free conditions and critically involve

49 -negative mice in germ-free (GF), but not in specific pathogen-free conditions develop the disease.

50 antibiotic treatment or breeding mice under specific pathogen-free conditions did not reduce AMP exp

51 antibiotic treatment or breeding mice under specific pathogen-free conditions did not reduce AMP exp

52 e skin of asymptomatic NC/Tnd mice housed in specific pathogen-free conditions induced kallikrein 5 a

53 tly enteric bacteria, even when reared under specific pathogen-free conditions with antibiotics.

54 mdx and wild-type C57BL/10 mice housed under specific pathogen-free conditions with deaths restricted

55 s microbial environment in mice housed under specific pathogen-free conditions, and the lack of pharm

56 When housed in specific pathogen-free conditions, dbh-/- mice had norma

57 tibiotic treatment increased their number in specific pathogen-free conditions.

58 mice remained healthy when maintained under specific pathogen-free conditions.

59 Cd1d-/- mice in comparison to WT mice under specific pathogen-free conditions.

60 Fecal transplants from mice reared in specific-pathogen-free conditions into germ-free Nlrp12-

61 infected with H. bilis Missouri strain under specific-pathogen-free conditions, followed by an intrav

62 Although healthy in specific-pathogen-free conditions, Il10(-/-); Nod2(-/-)

63 us carcinogenesis in FVB/N mice housed under specific-pathogen-free conditions.

64 ce on a uniform C57BL/6 background housed in specific-pathogen-free conditions.

65 3L, SCF, and ThPO to the levels displayed by specific pathogen-free control animals.

66 severe hemolytic anemia when inoculated into specific-pathogen-free-derived cats.

67 In specific-pathogen-free dogs experimentally infected with

68 Germfree transgenic rats were colonized with specific-pathogen-free enteric bacteria grown overnight

69 ged by a conventional environment, mice in a specific pathogen-free environment had less IgA depositi

70 DM incidence at 7 months for these mice in a specific pathogen-free environment on the respective die

71 use of antibiotic (Bactrim) prophylaxis in a specific pathogen-free environment, however, impedes inf

72 jugated keyhole limpet hemocyanin (KLH) in a specific pathogen-free environment.

73 with specified bacteria, and mice housed in specific pathogen-free environments.

74 NOD2-/- and C57BL/6J mice, maintained in a specific pathogen-free facility, were given antibiotics,

75 L/lpr genetic background and maintained in a specific pathogen-free facility.

76 colonization of the ferret stomach, ferrets specific pathogen free for H. mustelae were inoculated w

77 e of infection with H. mustelae, 19 ferrets, specific pathogen free for H. mustelae, were given eithe

78 sed global metabolomic analysis on bile from specific-pathogen-free, germ-free, Citrobacter rodentium

79 cecum was excluded from the fecal stream in specific pathogen-free HLA-B27 transgenic (TG) rats with

80 body weight as the wild type mice under our specific pathogen-free housing condition and showed no s

81 tionally important microbiota fixation under specific pathogen-free housing conditions.

82 us ileitis and colitis after 16 mo of age in specific pathogen-free housing conditions.

83 Specific pathogen-free IL-10 KO mice failed to develop i

84 We have previously shown that specific pathogen-free IL-10-deficient (IL-10 KO) mice d

85 Specific pathogen free Il10(-/-) mice were gavaged with

86 Germ-free and specific pathogen-free Il10(-/-) and germ-free Il10(-/-)

87 Specific-pathogen-free Il10(-/-), Nod2(-/-), and Il10(-/

88 een a TH2 response and immune suppression in specific-pathogen-free inbred cotton rats which were inf

89 We have previously shown that specific-pathogen-free interleukin-10 (IL-10)-deficient

90 leukin-17 prevented arthritis development in specific-pathogen-free K/BxN mice resulting from a direc

91 n, suggesting that many, if not most, TCE in specific pathogen-free laboratory mice may be Ag-indepen

92 endent T cell clonal expansions found in old specific pathogen-free laboratory mice.

93 from sheep clinically free of OEA, and from specific-pathogen-free lambs experimentally infected wit

94 inistered to eight cesarean section-derived, specific-pathogen-free macaques 14 to 42 days of age.

95 Specific pathogen-free male Sprague Dawley rats.

96 This hypothesis was tested in alcohol-fed, specific pathogen-free, male Sprague-Dawley rats.

97 istory and corresponding medLN hypoplasia in specific pathogen-free mice alter their immune response

98 e mice NLOs, albeit in lower numbers than in specific pathogen-free mice and following co-housing wit

99 thesized that a critical distinction between specific pathogen-free mice and nonhuman primates or hum

100 xposure to 'normalize' the immune systems of specific pathogen-free mice and queried the impact on br

101 m drug-free patients with schizophrenia into specific pathogen-free mice could cause schizophrenia-li

102 how the naive, neonate-like immune system of specific pathogen-free mice differs dramatically in comp

103 of these genera was significantly higher in specific pathogen-free mice early in life compared with

104 However, serum IgA of specific pathogen-free mice showed more galactosylation

105 elative increase in PP after PPVL in ASF and specific pathogen-free mice was not significantly differ

106 Male C57BL/6T specific pathogen-free mice were administered a tetracyc

107 inal epithelial cells and dendritic cells of specific pathogen-free mice, expressed much lower levels

108 Specific pathogen-free mice, obtained from different ven

109 omeostatic ISG signature in the intestine of specific pathogen-free mice.

110 ling of four tissue types from germ-free and specific pathogen-free mice.

111 f resident gammadelta T cells in the SLOs of specific pathogen-free mice.

112 tein are abundant in community-colonized and specific pathogen-free mice.

113 ge) for fecal microbiota transfer (FMT) from specific pathogen-free mice.

114 and allergic asthma as compared with that of specific pathogen-free mice.

115 iveness of TCE, which arise spontaneously in specific pathogen-free mice.

116 Alveolar bone resorption can be induced in specific-pathogen-free mice by oral infection with Porph

117 sterix) and Igf1 in bone, and serum IGF1, in specific-pathogen-free mice suggest the commensal microb

118 Transfer of faeces from specific-pathogen-free mice to germ-free mice restored g

119 ogel, whereas exposure to luminal fluid from specific-pathogen-free mice-whose microbiota degrade gut

120 mparing metabolomics data from germ-free and specific-pathogen-free mice.

121 Using germ-free and specific pathogen-free mouse models in combination with

122 ciated with a complete gut microbiota from a specific-pathogen-free mouse), and Bifidobacterium denti

123 iota, and that exposure to the microbiota of specific pathogen-free MyD88-negative NOD donors attenua

124 d development of eczematous lesions in these specific pathogen-free NC/Tnd mice, which normally do no

125 etin also induced scratching behavior in the specific pathogen-free NC/Tnd mice.

126 enome sequence, and in vivo pathogenicity in specific-pathogen-free newborn cats.

127 Here we show that specific pathogen-free NOD mice lacking MyD88 protein (a

128 e the harboring of Helicobacter species [non-specific-pathogen-free (non-SPF) conditions].

129 In specific pathogen-free nonobese diabetic (NOD) mice, fem

130 We observed that under specific pathogen-free or germ-free conditions, intragas

131 A total of 48 specific-pathogen-free piglets were randomly and equally

132 Forty specific-pathogen-free pigs at 4 weeks of age were rando

133 Furthermore, in a reciprocal experiment, specific-pathogen-free pigs were experimentally infected

134 Specific-pathogen-free pigs were inoculated with one of

135 erimentally characterize the VP120 virus, 31 specific-pathogen-free pigs were randomly divided into t

136 uced by M. bovis BCG vaccination, 4-week-old specific-pathogen-free pigs were vaccinated with M. bovi

137 n an early study, we experimentally infected specific-pathogen-free pigs with two strains of HEV: swi

138 ential of these organisms was evaluated in a specific-pathogen-free rat model in which the feeding pa

139 Specific-pathogen-free rats that were infected with ACUS

140 Four groups of specific-pathogen-free rats were formed: S. mutans 10449

141 -pathogen-free (complete gut microbiota) and specific-pathogen-free re-conventionalized (germ-free mi

142 ced into a Helicobacter hepaticus-containing specific pathogen-free room, these lesions reappear.

143 mice, although it was attenuated relative to specific pathogen-free SAMP1/Fc mice.

144 Laboratory mice live in abnormally hygienic specific pathogen free (SPF) barrier facilities.

145 fferent microbiota: restricted flora (RF) vs specific pathogen free (SPF).

146 ngredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice giv

147 Specific pathogen-free (SPF) C57BL/6J or germfree 129S6/

148 sera from 35 client-owned, 20 feral, and 30 specific pathogen-free (SPF) cats for pre-existing AAV-b

149 Conventional laboratory mice housed under specific pathogen-free (SPF) conditions are the standard

150 Laboratory mice housed under specific pathogen-free (SPF) conditions are the standard

151 trosourea (ENU), numerous animals died under specific pathogen-free (SPF) conditions between 6 and 7

152 Also, WT mice raised in specific pathogen-free (SPF) conditions fared better aga

153 e skin of asymptomatic NC/Tnd mice housed in specific pathogen-free (SPF) conditions induced KLK5 and

154 Most animal models are raised in specific pathogen-free (SPF) conditions with relatively

155 ow (BM-->Tg(epsilon26)) causes colitis under specific pathogen-free (SPF) conditions.

156 e dentate gyrus in these mouse models and in specific pathogen-free (SPF) control mice.

157 mature germ-free (GF) mice with conventional specific pathogen-free (SPF) gut microbiota increases bo

158 lized autoimmunity, similar to those seen in specific pathogen-free (SPF) IL-2(-/-) mice.

159 Microbiota composition of specific pathogen-free (SPF) INS-GAS mice was quantified

160 of some preclinical findings generated using specific pathogen-free (SPF) laboratory mice to humans.

161 Specific Pathogen-Free (SPF) layer chickens were infecte

162 stane 8-iso-PGF2a in plasma and intestine of specific pathogen-free (SPF) Leghorn chickens challenged

163 These cells were not detected in specific pathogen-free (SPF) macaques free of RhCMV and

164 Naive CD4(+) T cells in specific pathogen-free (SPF) mice are characterized by t

165 tituting physiologic microbial experience to specific pathogen-free (SPF) mice induces durable immuno

166 n and tumors in GF and conventionally raised specific pathogen-free (SPF) mice treated with azoxymeth

167 inflammation that develops spontaneously in specific pathogen-free (SPF) mice with a targeted disrup

168 an allergic infant and in antibiotic-treated specific pathogen-free (SPF) mice, and prevented or trea

169 We found that, in sharp contrast to specific pathogen-free (SPF) mice, germ-free (GF) mice a

170 However, compared with disease in specific pathogen-free (SPF) mice, ileitis in GF mice is

171 m-free zebrafish embryos were colonized with specific pathogen-free (SPF) microbiota.

172 H pylori-specific pathogen-free (SPF) monkeys were experimentally

173 prone BioBreeding (BBdp) rats were housed in specific pathogen-free (SPF) or germ-free (GF) condition

174 f this vaccine were demonstrated in mice and specific pathogen-free (SPF) piglets.

175 ation of T cells adoptively transferred into specific pathogen-free (SPF) RAG-/- mice, but not in ger

176 Cohorts were transferred from specific pathogen-free (SPF) to conventional (non-SPF) a

177 germ-free (GF), intermediate in conventional specific pathogen-free (SPF), and highest in wild-type m

178 inhibitor ezetimibe reduces stool output in specific pathogen-free (SPF), but not GF mice.

179 vation during aGVHD using antibiotic-treated specific pathogen-free (SPF), germ-free (GF), and wildli

180 Here, we show in multiple specific pathogen-free (SPF), gnotobiotic, and germ-free

181 (WT) colonic macrophages from germ-free and specific pathogen-free (SPF)-derived mice produce IL-10,

182 re born and raised for two generations under specific pathogen-free (SPF, n = 69) or non-SPF conditio

183 that co-housing of germ-free (GF) mice with specific-pathogen free (SPF) mice at weaning (exGF) resu

184 omparative analyses conducted between GF and Specific-Pathogen Free (SPF) mouse models of autoimmunit

185 Bile and feces collected from specific-pathogen-free (SPF) chickens experimentally inf

186 d by clinicopathological characterization in specific-pathogen-free (SPF) chickens.

187 inal inflammatory response when reared under specific-pathogen-free (SPF) conditions, suggesting the

188 itions but develop only colitis when kept in specific-pathogen-free (SPF) environments.

189 Five specific-pathogen-free (SPF) Helicobacter-free cats were

190 (IL-10(-/-) mice) and potentiate colitis in specific-pathogen-free (SPF) IL-10(-/-) mice.

191 cattery cats and transferring these fleas to specific-pathogen-free (SPF) kittens housed in a control

192 Specific-pathogen-free (SPF) mice are widely used in bio

193 Germ-free mice, clean specific-pathogen-free (SPF) mice colonized with a micro

194 -10% of gut-associated germinal centres from specific-pathogen-free (SPF) mice contain highly dominan

195 ent comparisons of germ-free (GF) and normal specific-pathogen-free (SPF) mice have revealed the impa

196 To test this, antibiotic-treated specific-pathogen-free (SPF) mice were given jejunal, ce

197 fasting glycemia in high-fat diet (HFD)-fed specific-pathogen-free (SPF) mice, supporting a role for

198 ne had catabolic effects on alveolar bone in specific-pathogen-free (SPF) mice.

199 c(Min/+) ;Il10(-/-) mice and exposed them to specific-pathogen-free (SPF) or colorectal cancer-associ

200 Moreover, the development of specific-pathogen-free (SPF) oysters has enabled assessm

201 hogenicities of the mutants, we utilized the specific-pathogen-free (SPF) pig model for HEV and a uni

202 s scrofa) raised under different conditions: specific-pathogen-free (SPF) pigs and domestic pigs from

203 ty of the chimeric infectious DNA clones, 40 specific-pathogen-free (SPF) pigs were randomly assigned

204 in the upper and lower respiratory tracts of specific-pathogen-free (SPF) young turkeys.

205 load to levels of conventionally colonized (specific pathogen-free [SPF]) animals and SCFA supplemen

206 Male specific pathogen-free Sprague-Dawley rats.

207 Specific pathogen-free Sprague-Dawley rats.

208 re viable and fertile in a controlled-access specific-pathogen-free vivarium, showed no major morphol

209 s with faecal microbial transplantation from specific pathogen-free wild-type and Nlrp6(-/-) animals.