ライフサイエンスコーパス: specific recognition

1 advantage of signal amplification and highly specific recognition.

2 rease provides full assurance of a perfectly specific recognition.

3 ew paradigm for mixed-base-pair DNA sequence-specific recognition.

4 g an additional means of confirmation of the specific recognition.

5 ive events that are uniquely associated with specific recognition.

6 e sequence-interrogation phase that precedes specific recognition.

7 cient coupled binding and folding for facile specific recognition.

8 the screening reveals no change in sequence-specific recognition.

9 t exhibit sequence-specific and non-sequence-specific recognition.

10 PEP dependent and require sigma factors for specific recognition.

11 specific process, which facilitates category-specific recognition.

12 he TCR either obliterated or enhanced target-specific recognition.

13 etween hCLDN-9 and cCpE that explain isoform-specific recognition.

14 e Ag-nonspecific and thus, independent of Ag-specific recognition.

15 f variable domains in Dscam mediates isoform-specific recognition.

16 inding, thermodynamic stability and sequence specific recognition.

17 tant increment of binding energy to sequence-specific recognition.

18 f the exocyclic amino group of G in sequence-specific recognition.

19 Specific recognition ability is directly built into the

20 to produce complementary binding sites with specific recognition ability.

21 identifies important residues for substrate-specific recognition and acetylation by NatB enzymes.

22 Examples of the use of both specific recognition and array-based "chemical nose" app

23 al first step in Escherichia coli MMR is the specific recognition and binding of MutS to a heterodupl

24 The sequence-specific recognition and cleavage of Cas effector comple

25 sets of DNA-protein contacts to mediate site-specific recognition and cleavage.

26 T cells imparted high-avidity phosphopeptide-specific recognition and cytotoxic and cytokine-secretin

27 e enzymes' highly evolved mechanisms for the specific recognition and discrimination of native dNTPs.

28 cteristic spectral shifts resulting from the specific recognition and dose-dependent interaction of a

29 th the structural basis of this modification-specific recognition and how this recognition informs Rt

30 d the T cell receptor (TCR) and demonstrated specific recognition and lysis of HLA-A*02:01-positive D

31 ced by ZBP1 binding provides a mechanism for specific recognition and may facilitate the assembly of

32 DNA minor groove microstructure for sequence-specific recognition and offer new avenues to design syn

33 It reveals base-specific recognition and offers a molecular explanation

34 ctural features of the Ty3 PPT contribute to specific recognition and processing by its cognate RT.

35 l features of the PPT that contribute to its specific recognition and processing by reverse transcrip

36 in specific cells within the tissues and the specific recognition and removal of dying cells by a cle

37 olecularly imprinted sensor was designed for specific recognition and sensitive ratiometric detection

38 lock-and-key system to perform cell-subtype-specific recognition and siRNA delivery.

39 Many experimental techniques rely on specific recognition and stringent binding of proteins b

40 This network may play a key role in the specific recognition and strong binding of mannose oligo

41 R-Cas systems) that protect through sequence-specific recognition and targeted destruction of viral n

42 These interactions confer species-specific recognition and tropism for particular host tis

43 es with aptamer targeting ligands allows for specific recognition and ultrasensitive detection of can

44 s on metal surfaces as an event triggered by specific recognition between a probe and a target nuclei

45 trochemical signal can be achieved after the specific recognition between antibodies and antigens.

46 On the basis of the specific recognition between aptamer and MUC1 protein th

47 an mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which t

48 tion of packaging specificity, either (a) by specific recognition between capsid protein(s) and repli

49 cur during the first steps of infection, for specific recognition between host and bacteria, but also

50 of pathogenic bacteria, suggesting that the specific recognition between Pa-BfrB and Pa-Bfd is of wi

51 Protein-RNA complexes formed by specific recognition between RNA and RNA-binding protein

52 The fidelity of chain growth depends on specific recognition between successive subunits in each

53 Adaptive immunity depends on specific recognition by a T-cell receptor (TCR) of an an

54 suggest a structural basis for the sequence specific recognition by a transcription factor centrally

55 in, indicating that either motif may support specific recognition by Cdh1.

56 folds and revealed structural principles for specific recognition by cognate metabolites.

57 erminal region of helix 2 are sufficient for specific recognition by conserved and functionally impor

58 ine the features in sigma(S) responsible for specific recognition by Crl.

59 n the beta3 strand that are known to mediate specific recognition by DH domain containing GEFs.

60 ptors (CARs) have been used to enhance tumor-specific recognition by effector lymphocytes.

61 crobes of many types, and are the targets of specific recognition by many different viruses.

62 mature conformation and immune function via specific recognition by MHC-I-restricted CD8(+) T lympho

63 heir resolution in vivo is likely to require specific recognition by specialized enzymes.

64 Antigen-specific recognition by T cells is via the T cell recept

65 differentially displayed on tumor cells for specific recognition by T cells.

66 of the CenH3 alpha2 helix is sufficient for specific recognition by the chaperone for both budding y

67 Restriction activity requires capsid (CA)-specific recognition by the PRYSPRY domain of TRIM5alpha

68 novel proteins Ere1 and Ere2 mediates cargo-specific recognition by the retromer pathway.

69 Combining specific recognition capabilities with the excellent spa

70 Highly specific recognition cavities can be made into polymer m

71 s 140-fold stabilization of the extrahelical specific recognition complex, and that Y162 functions as

72 ression of AAG from nonspecific searching to specific-recognition complexes.

73 uence-independent interactions and vectorial-specific recognition domains.

74 Herein, we report a S. aureus-specific recognition element, isolated from phage monocl

75 e generic biosensor after incorporation of a specific recognition element, such as an aptamer for exa

76 comprising such redox groups, together with specific recognition elements (here antibodies), this ch

77 of which contains mismatch sites serving as specific recognition elements for mercury(II) or silver(

78 d as a screening method to identify pathogen-specific recognition elements.

79 single PEID platform in combination with the specific recognition elements.

80 ne monitoring require very rugged yet highly specific recognition elements.

81 by subtle differences between small, highly specific recognition elements.

82 comes can be quantified readily, the initial specific recognition events have been difficult to asses

83 preventing amyloidogenic oligomerization and specific recognition events that nucleate prion assembly

84 The cb-ApDCs exhibit high stability, specific recognition, excellent cellular uptake, and est

85 epeat (PPR) motif-containing family are site-specific recognition factors for either chloroplast or m

86 ling-circle mechanism that requires sequence-specific recognition for initiation, nicking of one of t

87 To determine the factors involved in the specific recognition function of a bacterial 8-oxoguanin

88 ace-enhanced Raman spectroscopy, SERS) and a specific recognition (immunoassay).

89 ride motifs may modulate carbohydrate-lectin specific recognition in a lectin-dependent manner when p

90 e for detecting specific IgE to CLV, and its specific recognition in patients with immediate reaction

91 the gametophytic self-incompatibility (GSI) specific recognition in Prunus.

92 Residues involved in unusual base-specific recognition in the minor groove of dsRNA are co

93 t, implicating the loop of Rtt106 in H3K56ac-specific recognition in vivo.

94 Semi-specific recognition, in which a molecular class rather

95 tudies illuminate how ClpXP transitions from specific recognition into a nonspecific unfolding and tr

96 peat" (NLR) proteins that translate pathogen-specific recognition into disease-resistance signaling.

97 The specific recognition is achieved by use of biotinylated

98 Current models suggest that specific recognition is driven by DGCR8 detection of sin

99 Achieving facile specific recognition is essential for intrinsically diso

100 Specific recognition is even maintained in biological ma

101 lignancies, but the nature of the induced Ag-specific recognition is largely unknown.

102 chia coli, acts by methylation- and sequence-specific recognition, leading to either methylation of D

103 surface, including protein determinants for specific recognition, linked to immune responses.

104 Understanding the molecular basis for this specific recognition may lead to novel therapeutic strat

105 However the specific recognition mechanism between TRIM24 and histon

106 ding has been studied extensively, structure-specific recognition mechanisms remain unclear.

107 and remaining challenges; and explores other specific recognition modalities that might be employed f

108 tch from a nonspecific search mode to a more specific recognition mode.

109 une response at the cellular level relies on specific recognition molecules to rapidly signal viral i

110 To explore whether the T-synthase encodes a specific recognition motif for Cosmc, we used deletion m

111 zyme that is required for SipA cleavage at a specific recognition motif that divided the protein into

112 ol of 1.4 million unique peptides identified specific recognition motifs for KalbTG in these peptides

113 eins these findings raise the possibility of specific recognition motifs within replication origins o

114 in defines the family and is responsible for specific recognition of a common sequence motif, 5'-GGA(

115 ntly shown to bind at least six proteins, by specific recognition of a consensus sequence in them.

116 site on each complex vary, providing for the specific recognition of a diverse repertoire of (D/E)XXX

117 ated neutralization involving both structure-specific recognition of a gp41 protein epitope and nonsp

118 Specific recognition of a gRNA packaging signal (Psi) ha

119 oteins, which are processed by sortases upon specific recognition of a highly conserved LPXTG motif.

120 be overcome in order to fully deal with the specific recognition of a highly diverse and complex ran

121 lly selects prespacers with 3' overhangs via specific recognition of a PAM, but how these prespacers

122 tion of protein synthesis occurs through the specific recognition of a stop codon in the A site of th

123 A critical function of HP is its specific recognition of a viral RNA signal termed epsilo

124 n-pi interaction contribute to selective and specific recognition of A- and H-type HBGAs.

125 The site-specific recognition of abasic sites and single base bul

126 king in somatic cells is also facilitated by specific recognition of acetylated MTs by motor proteins

127 quaternary structure of VH1 is essential for specific recognition of activated STAT1, which prevents

128 The specific recognition of adenovirus was investigated in t

129 Only moderate evidence of infection stage-specific recognition of Ags was observed.

130 Based on a sandwich ELISA and the specific recognition of antibody to E. coli O157:H7, the

131 This process is initiated by specific recognition of antigen through the B cell recep

132 Specific recognition of arabinosyl residues may help exp

133 al cyclic oligonucleotide signals and enable specific recognition of at least 180 potential nucleotid

134 d that the host specificity is determined by specific recognition of bacterially derived Nod factors

135 de a potential novel tool to investigate the specific recognition of base pairs, which is the basis o

136 e a new way to generate molecular probes for specific recognition of cancer cells.

137 T cells target and kill cancer cells by the specific recognition of cancer-associated antigens.

138 The aptasensor exploits the specific recognition of carbendazim by the aptamer immob

139 einhardtii cells to pan for VH H clones with specific recognition of cell-surface epitopes.

140 eceptor subfamilies have evolved towards the specific recognition of certain animal groups or chemica

141 of the ectodomains of these proteins is the specific recognition of cognate ligands, which are often

142 Riboswitches regulate gene expression via specific recognition of cognate metabolites by their apt

143 ation and adhesion of platelets, through the specific recognition of collagen by the alpha2-I domain

144 amplification with CRISPR-Cas enzymology for specific recognition of desired DNA or RNA sequences.

145 and we elucidate the molecular basis for its specific recognition of diaminopimelate-type peptidoglyc

146 ed that Thr-84 and Lys-169 play key roles in specific recognition of dicarboxylic keto (prephenate) a

147 is, promotes inclusion of weak exons through specific recognition of diverse cis-elements.

148 umber of combinatorial possibilities for the specific recognition of DNA (or RNA).

149 The mechanism of site-specific recognition of DNA by proteins has been a long-

150 Specific recognition of DNA by transcription factors is

151 Sequence-specific recognition of DNA is a critical step in gene t

152 ional exchange process that was modulated by specific recognition of DNA, indicating allosteric proce

153 Specific recognition of dopamine by the aptamer allowed

154 represents an attractive method for sequence-specific recognition of double-stranded nucleic acids.

155 sulting label-free configuration enabled the specific recognition of EcOMPs in water by monitoring th

156 We propose that specific recognition of endogenous presented peptides, r

157 k docking interactions facilitate the highly specific recognition of ERK2 by Ets-1, and enable the op

158 We report the presence of antigen-specific recognition of ESAT-6 and KatG in T cells from

159 The specific recognition of FAP is based on the interaction

160 hly sensitive sensor built on the remarkably specific recognition of glyphosate by its physiological

161 Conversely, non-specific recognition of gTSSA-I by non-endemic malaria s

162 o engage the H2A.Z-H2B dimer for optimal and specific recognition of H2A.Z.

163 Specific recognition of hinge epitopes was dependent on

164 Here we show a critical role for specific recognition of histone H3 trimethylated at lysi

165 riking mechanistic commonality for the state-specific recognition of histone lysine methylation, it i

166 ate tumor regression in melanoma through the specific recognition of HLA-restricted peptides.

167 cidate the structural basis for the sequence-specific recognition of human ISG15, we determined the c

168 Full details of the specific recognition of hypoxanthine are revealed, allow

169 ysis in solution was independent of the very specific recognition of immobilized peptides by MMP-13;

170 bute to TlyA domain interactions, as well as specific recognition of its two structurally distinct ri

171 niles and neonates, sensory cues that enable specific recognition of juvenile mice are unknown.

172 l active-site interactions important for the specific recognition of l-malate, but not other alpha-hy

173 domain of VioA is mainly responsible for the specific recognition of l-tryptophan.

174 e LysM1 domains of these receptors determine specific recognition of ligands and discriminate between

175 ies show that Yos9(22-421) exhibits sequence-specific recognition of linear peptides from the ERAD su

176 d for the generation of molecular probes for specific recognition of liver cancer cells.

177 The selectivity depended on specific recognition of LTR loop residues; the mechanism

178 acts as one functional unit in the sequence-specific recognition of lysine-14-acetylated histone H3

179 llows more specific interactions such as the specific recognition of melanophilin by the myosin Va is

180 sm for the generation, stabilization, and/or specific recognition of membrane discontinuities.

181 In this study, we demonstrate that specific recognition of messenger RNAs (mRNAs) by RNA-bi

182 Specific recognition of methylated DNA constrains the st

183 f Galalpha and GalNAc reactivity and disease-specific recognition of microbial antigens, self-antigen

184 r probe designs result in very efficient and specific recognition of model dsDNA targets in buffers o

185 ficant contribution of the 343 side chain to specific recognition of multivalent microbial ligands, i

186 Our structures provide insights into specific recognition of MycG4 by BMVC and useful informa

187 olecularly imprinted polymers (MIPs) for the specific recognition of NMP22 target molecules.

188 substitutions that dramatically enhanced the specific recognition of NY-ESO-1(+)/HLA-A*02(+) tumor ce

189 urally related metallopeptidases require the specific recognition of O-linked glycan modifications vi

190 This SPR assay allows specific recognition of oligomeric intermediates that ra

191 A pair of antibodies was used to achieve the specific recognition of OP-AChE that was prepared with p

192 We propose a model for sequence-specific recognition of packaging initiation sites by la

193 providing a generally applicable method for specific recognition of PC.

194 To ensure specific recognition of PEGylated species, an immunoaffi

195 membrane binding, including electrostatics, specific recognition of phospholipid headgroups, sensiti

196 ure of an OCRE-SmN peptide complex reveals a specific recognition of poly-proline helical motifs in S

197 ew STUbL, which used three adjacent SIMs for specific recognition of poly-SUMO2/3 chains, and used Ub

198 ve avidity to achieve stable, but reversible specific recognition of polyvalent targets.

199 rom healthy donors or CLL patients conferred specific recognition of primary B-CLL and mantle cell ly

200 The specific recognition of protein surface elements is a fu

201 activates ectopic transcription not through specific recognition of PTA gene promoters but by releas

202 Here, we utilize the highly specific recognition of ribose by ribose-binding protein

203 midazole and pyridinium chemotypes allow for specific recognition of RNA motifs.

204 h the role of the zinc finger domain in base-specific recognition of RNA.

205 sed conformation with base flipping and base-specific recognition of RSSs.

206 Lys-313 and Val-316 involved in the species-specific recognition of Rubisco are located near the tip

207 LC6 and LC15 exhibited strong binding to and specific recognition of S. japonicum eggs, but not eggs

208 s permitted us to delineate details of clade-specific recognition of SAMHD1 by lentiviral Vpx protein

209 The photocurrent variation related to the specific recognition of SCCA shows a linear relationship

210 The molecular basis for specific recognition of sigma(S) by Crl, rather than the

211 ly regulated infection process, in which the specific recognition of signal molecules is a key step t

212 Protein phosphorylation, driven by specific recognition of substrates by kinases and phosph

213 ssembled onto gold electrode surface for the specific recognition of target dsDNA (dsDNA-T), which in

214 cillus thuringiensis , often depend on lipid-specific recognition of target membranes.

215 nizes the structure of the seed sequence for specific recognition of target mRNAs.

216 trode and used as the capture probes for the specific recognition of target single-stranded DNA (ssDN

217 CAR T cells were developed that upon specific recognition of TEM8 secreted immunostimulatory

218 structure elucidates the basis for sequence specific recognition of the -24 element, orients sigma(5

219 To investigate whether specific recognition of the -35 element would affect the

220 with RNA by a bipartite mechanism involving specific recognition of the 5'-terminal triphosphate and

221 The sequence-specific recognition of the amplicon by the CRISPR guide

222 techniques to create a sensor layer for the specific recognition of the bacterial surface markers li

223 atypical activation segment well adapted for specific recognition of the basic histone tail.

224 Specific recognition of the cargo that molecular motors

225 ogether, these data establish a paradigm for specific recognition of the conformation of poly(A) RNA

226 are expected to result in strong binding and specific recognition of the DNA minor groove.

227 Specific recognition of the DRE is determined locally by

228 Base-specific recognition of the flanking DNA by conserved am

229 different acetylation patterns may result in specific recognition of the H4 histone tails by protein

230 rine and phosphoinositides are well defined, specific recognition of the headgroup of the zwitterioni

231 Kinetochore assembly depends on specific recognition of the histone variant CENP-A in th

232 stronger CD8(+) T-cell responses through the specific recognition of the HIV-1 capsid by the immune s

233 3' end processing by modulating the sequence-specific recognition of the HIV-1 pre-mRNA by 9G8.

234 The specific recognition of the intermediate promoter in MOC

235 sponding peptide substrates through sequence-specific recognition of the leader sequence, which is re

236 This work demonstrates that the specific recognition of the norovirus subgenomic promote

237 as solved at a resolution of 1.15 A, reveals specific recognition of the peptide alpha-amino group vi

238 proposed models for the homologous ERAP1, no specific recognition of the peptide C terminus by ERAP2

239 the P450 enzymes with the NRPS, followed by specific recognition of the peptide cyclization state by

240 on the beta6/beta7 loop of Cd-SrtB dominate specific recognition of the peptide substrate PPKTG.

241 Consistent with their role in base-specific recognition of the promoter, R91, D81 and D84 a

242 agA directly associates with RUNX3 through a specific recognition of the PY motif of RUNX3 by a WW do

243 Specific recognition of the RNA element occurs via an ar

244 -binding domain is not required for sequence-specific recognition of the targeted mRNA transcript.

245 he beta' RNAP subunit is sufficient to allow specific recognition of the TG motif of the extended -10

246 Mia40 accelerates Cox19 folding through the specific recognition of the third Cys in the second heli

247 the protein import process is maintained by specific recognition of the transit peptide of preprotei

248 Previously, we showed that base-specific recognition of the tRNA(Pro) acceptor stem is c

249 hermore, point mutations in Zta that disrupt specific recognition of the UEE hairpin are defective fo

250 such a circular array of HTH motifs enables specific recognition of the viral genome for initiation

251 a virus (EBOV) infections, but their species-specific recognition of the viral glycoprotein (GP) has

252 specificity of Rev for the RRE and thus the specific recognition of the viral RNA.

253 This is proposed to involve sequence-specific recognition of the X at approximately 150-300 c

254 It is not clear how GluRS2 achieves specific recognition of tRNA(Gln) while rejecting the tw

255 Unfortunately, specific recognition of two of the four possible base pa

256 However, specific recognition of two of the four possible base pa

257 ovel mechanism for the simultaneous sequence-specific recognition of two UGUA elements within the pre

258 inity complexes with ARE substrates based on specific recognition of U-rich sequences by both the ATP

259 the molecular basis underlying the sequence-specific recognition of UACAU and the role of residues i

260 H2A-Lys15 highlighting the diversity in site-specific recognition of ubiquitylated nucleosomes.

261 CR alpha/beta assembly process, which allows specific recognition of unassembled clonotypic chains by

262 RNAs from exonuclease digestion via sequence-specific recognition of UUU-3'OH.

263 ree receptor-based pathways activated by the specific recognition of various virus-associated pattern

264 with strong pathogen preference by virtue of specific recognition of viral proteins.

265 Thus, specific recognition of VWF depends on cooperative, modu

266 reveal that pol II has an asymmetric (strand-specific) recognition of phosphodiester linkage.

267 sets of HDs with overrepresented residues at specific recognition positions, implying the selection o

268 Hereby these oligonucleotides can act as specific recognition probes.

269 Here, it is not the selectivity of a specific recognition process between a particular DCL me

270 nent supramolecular hybrid system built from specific recognition processes involving a Dawson-type p

271 ption (FACT), a heterodimer of the structure-specific recognition protein 1 (SSRP1) and the human hom

272 show, using mammalian cells, that structure-specific recognition protein 1 (SSRP1) is a novel regula

273 Among these proteins, structure-specific recognition protein 1 (SSRP1), a subunit of the

274 HP1c interacts with the SSRP1 (structure-specific recognition protein 1) subunit and the intact F

275 fish mutants for the gene encoding Structure specific recognition protein 1a (Ssrp1a), which, togethe

276 has indicated that absence of a single site-specific recognition protein can result in loss of editi

277 The specific recognition reaction is activated when it encou

278 ind that high local stability at the variant-specific recognition residues rationalizes its known sel

279 Site-specific recognition selectivity and specificity for pho

280 al dsDNA loop translocation rightward of the specific recognition sequence 5'-CTnGAyG-3' as written (

281 findings suggest that RRM interactions with specific recognition sequences alone do not account for

282 es (ZFNs) induce DNA double-strand breaks at specific recognition sequences and can promote efficient

283 ns unclear how the interaction of gamma with specific recognition sequences coordinates directional D

284 binding of proteins and/or noncoding RNAs to specific recognition sequences or secondary structures w

285 the entire length of coding regions only at specific recognition sequences.

286 Identification of a specific recognition site on PrP(C) that traps Abeta in

287 l analysis to show that FANCJ possesses a G4-specific recognition site.

288 Introduction of two specific recognition sites into the primary sequence of

289 together determine the overall structure and specific recognition sites of small molecules or protein

290 homology across the antiparallel recombinase-specific recognition sites present in recombinase-depend

291 The use of fluorescence-tagged CBMs with specific recognition sites provided a quantitative way t

292 oMIP offers the advantage of large number of specific recognition sites with tailored geometry, as th

293 tic oligonucleotides containing zero to five specific recognition sites, called metboxes.

294 ersion of genomic DNA flanked by recombinase-specific recognition sites, coupled with gene targeting

295 is required for transitioning into the site-specific recognition state.

296 ein A and antibody binding) for tailored and specific recognition to take place.

297 tion within 100min and exhibited significant specific recognition toward the ascorbic acid (AA) with

298 Based on direct sequence-specific recognition, TRIM5alpha delivered its cognate c

299 matrix (ECM) promotes both cell adhesion and specific recognition, which is essential for central dev

300 Given their often structured nature, specific recognition with an antibody fragment becomes f