ライフサイエンスコーパス: specification

1 nd cdx4, which mediate anterioposterior axis specification.

2 ely repressed by GSX2/DLX-mediated cell fate specification.

3 cting the molecular mechanisms governing PGC specification.

4 ranscription factor involved in B lymphocyte specification.

5 cies differences in neuronal projection fate specification.

6 of progenitor cells to promote neural crest specification.

7 ich along with OCT4 are responsible for BCSC specification.

8 spatial self-organization and embryonic cell specification.

9 ng the divergent molecular mechanisms of PGC specification.

10 ression, but not SHR-dependent ground tissue specification.

11 a master transcription factor for lymphatic specification.

12 anscriptional networks controlling cell-fate specification.

13 lar stress pathways, which impairs cell-type specification.

14 ith defects in photoreceptor subtype lineage specification.

15 ing data from each survey to a standard data specification.

16 f MGE cells to regulate cortical interneuron specification.

17 receptor function, and synaptic connectivity specification.

18 progenitors is associated with chondrogenic specification.

19 the number of CD41(+) HSPCs downstream of HE specification.

20 or interactions before and after anchor cell specification.

21 sphatase-1 in cell proliferation and lineage specification.

22 atenin to promote Wnt signaling and mesoderm specification.

23 5 genes, suggesting a disruption in cellular specification.

24 originate from gene duplication and paralog specification.

25 anscription factor within islet cell subtype specification.

26 toward three lineages of neuronal-glial fate specification.

27 lating pancreatic progenitor cell growth and specification.

28 s required, it was not sufficient for tissue specification.

29 d on functional annotation in organ boundary specification.

30 ne regulatory mechanisms during keratinocyte specification.

31 rogramming to investigate natural behavioral specification.

32 stem cell functions, lineage commitment and specification.

33 c inactivation, causes defects in glial cell specification.

34 em development and morphogenesis and pattern specification.

35 ote appropriate class switching, not lineage specification.

36 sity can provide a basis for cellular signal specification.

37 iption factors that drive pancreatic lineage specification.

38 able elements during human prospermatogonial specification.

39 ROS) are linked to proliferation and lineage specification.

40 riptional programs for proliferation or cell specification.

41 h we show controls PC maturation after their specification.

42 e evolutionary history of neuronal cell-type specification.

43 oupling epithelial identity with mesenchymal specification.

44 egulates Pax7-dependent neural crest lineage specification.

45 oncentration to satisfy current seed quality specifications.

46 d robust to various changes in variables and specifications.

47 Balance Analysis (LK-DFBA), to satisfy these specifications.

48 on nitride does not meet required dielectric specifications.

49 ely robust to alternative model and variable specifications.

50 f adoption peak at local scales in all model specifications.

51 h characteristics are varied to meet certain specifications.

52 iption factors and, thus, subpopulation fate specifications.

53 nd (3) conducting joint inference across all specifications.

54 r findings were robust to a variety of model specifications.

55 ly inherited fate determinants drive lineage specification(2), but this is not thought to be the case

56 ified, statistically valid and non-redundant specifications; (2) displaying the results graphically,

57 and tested for SOR and SOL according to ISO Specification 4049 (2009).

58 responsiveness to primordial germ cell (PGC) specification, a unique functional feature of formative

59 ur updated three-stage model for interneuron specification: an initial cardinal step, allocating inte

60 s and their interactions that drives lineage specification and also identifies stage-specific interac

61 ent after implantation, including germ-layer specification and axial organization(1-3).

62 Embryonic cell fate specification and axis patterning requires integration o

63 Lymphocyte lineage specification and commitment requires the activation of

64 progenitors were comprised of a spectrum of specification and commitment states characterized by mul

65 nscription factors can function in cell fate specification and differentiated cell behavior, and that

66 ctors that regulate vertebrate photoreceptor specification and differentiation are complex, and our u

67 , but the mechanisms controlling their fetal specification and differentiation are poorly understood.

68 we revealed a role for Neurog2 in cell fate specification and differentiation of ventromedial -speci

69 dinately orchestrate mammary luminal lineage specification and endocrine response, and also are often

70 ble for investigating the mechanisms of hPGC specification and epigenetic reprogramming.

71 ble to undergo symmetry-breaking, germ layer specification and even morphogenesis.

72 e that Hh signaling is required for both PGC specification and general endomesodermal patterning.

73 the importance of RA signaling in endocrine specification and identify conserved mechanisms by which

74 neage-driving networks underlying glial fate specification and identify Zfp36l1 as necessary for olig

75 clear, and uncertainties exist regarding the specification and implementation of a screening programm

76 al in hematopoietic stem and progenitor cell specification and in the development of acute leukemia.

77 3 to directly promote distal epithelial fate specification and inhibit epithelial differentiation.

78 s and across species are important in tissue specification and limb morphogenesis, tendon cell biolog

79 remodeler Hmga1 is highly expressed prior to specification and maintained in migrating chick neural c

80 distal enhancers is essential for cell-fate specification and maintenance of cellular identities.

81 after called E2A) being essential for B-cell specification and maturation.

82 ects on embryonic stem cell (ESC) germ layer specification and mesodermal specification, uncovering c

83 ure transcriptional profiles for hepatoblast specification and migration, including the emergence of

84 polarization as well as subsequent cell fate specification and morphogenesis.

85 Notch signalling is required for T-cell fate specification and must be maintained throughout beta-sel

86 discuss the roles of Hippo pathway in tissue specification and organ development during organogenesis

87 ng floral organ initiation, growth, identity specification and patterning.

88 tential to identify deeply conserved lineage specification and pluripotency factors, and can extend o

89 etal stages, consistent with defects in mTEC specification and progenitor expansion.

90 We show that improper specification and proliferation of second heart field (S

91 of the organoids revealed enhanced GABAergic specification and reduced cell proliferation following d

92 bryo in vivo, Ybx1 is required for forebrain specification and restricting mid-hindbrain growth.

93 pment relies on an interplay between genetic specification and self-organization.

94 The transcription factor Zeb2 controls fate specification and subsequent differentiation and maturat

95 nalysis provides insights into early lineage specification and suggests that a similar mechanism init

96 this gradient is essential for the stem cell specification and the apical-basal patterning of the SAM

97 he mouse, with a particular focus on lineage specification and the new insights that have been gained

98 ays that control unique aspects of cell fate specification and tissue morphogenesis.

99 suggest that Notch is critical for FCSC fate specification and TMJ homeostasis, and reveal that inhib

100 nhr-67 (NR2E1/TLX), that mediate anchor cell specification and/or invasive behavior.

101 can be constructed to fulfill various design specifications and one-pot assembly reactions, thus serv

102 Our results are robust to alternative specifications and variable definitions.

103 obabilistic uncertainty in parameters, model specification, and data.

104 transcriptional program in tracheoesophageal specification, and discover that the majority of the tra

105 ic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguis

106 tatic intestinal epithelial renewal and fate specification, and for regeneration after colitis induct

107 e address questions concerning the ontogeny, specification, and function of the cell types of a repre

108 ms, including altered patterning, progenitor specification, and neurite growth, prefigure dysphagia a

109 Glucose signaling has no role in ICM specification, and this process of developmental metabol

110 differentiation, cell proliferation, pattern specification, and tissue morphogenesis.

111 ne morphogenetic protein signaling, alveolar specification, and tumor suppression.

112 initions of Asian dust, study designs, model specifications, and confounder controls.

113 , clinical evidence base, clarity of measure specifications, and feasibility and applicability.

114 e developed, each with different techniques, specifications, and turnaround time.

115 d functions to canalize aspects of cell-fate specification, animal size regulation, and molting.

116 impediments to ISC proliferation and lineage specification appeared to be abnormally elevated forkhea

117 rchitecture targeting energy and performance specifications appropriate for applications in supercond

118 delling of the intestinal wall and cell-fate specification are closely linked.

119 ct mechanisms for primordial germ cell (PGC) specification are observed within Bilatera: early determ

120 olling hypothalamic patterning and cell fate specification are poorly understood.

121 Results from both unadjusted and adjusted specifications are reported, the latter adjusting for ag

122 Results from both adjusted and unadjusted specifications are reported, the latter adjusting for ba

123 ity of PRKAB2 was indispensable for mesoderm specification as shown by gene expression analysis and h

124 nd is sufficient to drive cardiomyocyte fate specification, as assessed by Notch reporter expression

125 r understanding early tracheoesophageal fate specification at the genome-wide level.

126 during neural crest development to regulate specification at the neural plate border, and subsequent

127 cilitated the genetic rescue of granulocytic specification but not post-commitment defects in innate

128 Studies of cell fate focus on specification, but little is known about maintenance of

129 ogate the importance of CenDNA in centromere specification by developing a system to rapidly remove a

130 riptional profile for sinusoidal endothelial specification by E8.75.

131 e protein co-factor Ldb1 regulates cell fate specification by interacting with LIM-homeodomain (LIM-H

132 cesses that control cell division, cell-type specification, cell migration, cellular differentiation,

133 ted promotion of genes involved in forebrain specification, cell proliferation, or neuronal different

134 es suggest a three-factor model for regional specification: competence factors (e.g., AP1) make chrom

135 of mesoderm development and left-right axis specification; components for nervous system development

136 However, there are no specifications concerning the fraction of nanoparticles

137 l stretching promoted BMP-dependent mesoderm specification, confirming that tissue-level forces can d

138 tra/extracellular environment during lineage specification could affect stem cell fate decisions resu

139 Using minimal exposure to specification cues, we derive stem cells from formative

140 Specification curve analysis reveals that one finding is

141 this source of noise and bias, we introduce specification curve analysis, which consists of three st

142 Specification-curve analysis revealed important variatio

143 Then, after female fate specification, Cyp19a1a regulates subsequent oocyte matu

144 to account for the evolution of various fate-specification decisions, including viral latency.

145 , allowing readers to identify consequential specifications decisions; and (3) conducting joint infer

146 t paradoxically induces hyperplasia and fate specification defects in quiescent stem cells.

147 In zebrafish, germ layer specification depends on the inheritance of maternal mRN

148 actors (TFs) are involved in controlling the specification, differentiation and function of multicili

149 H7 expression in regulation of photoreceptor specification during late retinogenesis.

150 To study signaling dynamics and fate specification during preimplantation development, we gen

151 changes may also play a key role in lineage specification during stem cell differentiation.

152 understanding of gene regulation and lineage specification during this crucial developmental window.

153 PRDM14 loss results in significantly reduced specification efficiency and an aberrant transcriptome o

154 Following anchor cell specification, egl-43, hlh-2 and nhr-67 function largely

155 Here, we report that this first cell fate specification event is controlled by glucose.

156 feedback to attain the level of the neuronal specification factor PTF1A necessary for generating corr

157 were involved in functions such as polarity specification, floral organ development, meristem develo

158 ppocampal circuits and provides useful model specifications for biologically realistic neural network

159 Genome specifications for dynamics that can map specific gene e

160 g of disease such that patients meet current specifications for long-term oxygen therapy.

161 epicardial-derived cells and revealed their specification from adipogenic to fibrogenic cells in the

162 pment is essential for normal organ size and specification from SOX2+ PSCs.

163 ion and opens new avenues to study cell-type specification, function, and evolution in plants.

164 e possible because 1) the anterior-posterior specification GRN is flexible over time in the developin

165 nt vascular tissues involves tissue identity specification, growth, pattern formation and cell-type d

166 r, the role of RA signaling during endocrine specification has not been fully explored.

167 Across all model specifications, however, income inequality between count

168 opathy variant interpretation framework; the specifications implemented for the study are presented h

169 r receptors orchestrates functional synaptic specification in a neural circuit.

170 matin states are reorganized during cellular specification in an in vivo system, we examined the func

171 level forces can directly regulate cell fate specification in early human development.

172 Current understandings of cell specification in early mammalian pre-implantation develo

173 ing both signaling pathways in proximodistal specification in human lung development.

174 In contrast to paradigmatic models of fate specification in mostly motionless cell packings, this f

175 e we investigate the molecular basis for PGC specification in Nematostella, a representative pre-bila

176 e neurogenesis, migration, and axo-dendritic specification in post-mitotic neurons.

177 is the only factor promoting the dorsal axis specification in the amphioxus, whereas Wnt/beta-catenin

178 the mode of Notch activation in binary fate specification in the Drosophila spermathecal linage, whe

179 t the mechanisms that regulate early lineage specification in the mouse may differ in other mammals,

180 ssemble a comprehensive GRN for endomesoderm specification in the sea star from zygote through gastru

181 ranscriptional programs underlying cell-type specification in this clade.

182 iption factor that plays a role in cell type specification in various tissues.

183 for Drosophila ISC proliferation and lineage specification in vivo and acts at least partially by rep

184 three approaches and compared with the known specifications in the calibration phantom.

185 Understanding the steps for RGC specification into ipsi- and contralateral subtypes will

186 Our data suggest that flight feather specification involved the co-option of the pre-existing

187 Developmental cell fate specification is a unidirectional process that can be re

188 cover that the crucial role of Prdm14 in PGC specification is conserved between rat and mice, by anal

189 Regional specification is critical for skin development, regenera

190 Lineage specification is governed by gene regulatory networks (G

191 This early fate specification is not apparent using markers or morpholog

192 To determine whether germ layer specification is robust to altered cell-to-cell position

193 us cell mixing reveals how robust early axis specification is to spatial disruption of maternal pre-p

194 as floral transition in spring, floral organ specification, low temperature-mediated floral bud break

195 tification of factors influencing centromere specification, maintenance, and propagation through many

196 However, titanium mesh pore size specifications may influence bone quality.

197 ive phenotypes resulting from defects in the specification, migration and/or function of GnRH neurons

198 lymerases often do not have the "performance specifications" needed for transformative technologies.

199 the other players of the anterior-posterior specification network to generate a new wing pattern.

200 Our findings contribute to the detailed specification of a computational model of speech percept

201 r development, hmx3a is required for correct specification of a subset of spinal interneuron neurotra

202 This process requires the specification of a subset of vascular endothelial cells

203 egated to PACs, Jag1 became critical for the specification of all but the most proximal BPs, and BPs

204 ion during retinal progenitor maturation and specification of all seven major retinal cell types.

205 2L2 play critical and redundant roles in the specification of axillary floral meristems and lemma ide

206 use developmental atlases (such as conserved specification of blood cells).

207 /Medea binding motifs, can contribute to the specification of BMP target genes in efferent neuron sub

208 in tissues to organize tissue repair and the specification of cell fate during development.

209 mechanosensitive beta-catenin/Wnt-dependent specification of cell fate during gastrulation illustrat

210 e normal development of hepatocyte polarity, specification of cell-cell junctions, and canalicular fo

211 ll proliferation, but rather results from re-specification of cells from the neural crest-derived sox

212 Regulatory mechanisms mediating the genetic specification of cephalic neural circuits in arthropods

213 r repertoires, suggesting that developmental specification of convergence ratio allows functional rob

214 gh the role of transcription factors in fate specification of cortical interneurons is well establish

215 ng the regulatory network that underlies the specification of distinct progenitor and neuronal cell i

216 /beta-catenin signaling is necessary for the specification of dorsal cell fate in a stage-dependent m

217 using on key transition stages for cell type specification of each germ layer.

218 background, our data suggest that unbalanced specification of excitatory and inhibitory neurons durin

219 develops is unknown; it could involve early specification of extremely precise synaptic connections

220 This algorithm requires no a priori specification of frequency bands.

221 factor (SCF) together with CXCL12 induce the specification of human cDCs from CD34(+) hematopoietic s

222 The chromatin landscape underlying the specification of human cell types is of fundamental inte

223 The gene expression program underlying the specification of human cell types is of fundamental inte

224 ost commonly, LRP initiation starts with the specification of just one FC longitudinally.

225 asa1 in mouse embryos did not affect initial specification of LVV or central VV, but did affect their

226 he GC reaction and highlights the functional specification of macrophage subsets in the MZ compartmen

227 We encourage the clear specification of manipulable microbial elements that can

228 iar to ForB indicate transient states in the specification of membrane domains before differentiation

229 w this pathway contributes to the continuous specification of movements that endows our voluntary act

230 ing induction of the neural plate border and specification of neural crest cells.

231 of gene expression control in the molecular specification of neuronal morphology during development.

232 level, and reveal a process of local tissue specification of neutrophils in the ischemic heart chara

233 emergence of diverse cell subtypes and areal specification of newborn neurons.

234 stablishment of the principal limb axes, the specification of pattern, the integration of pattern for

235 s increasingly well understood, the basis of specification of postsynaptic neurotransmitter receptors

236 y, formation of a bipolar embryonic sac, and specification of primordial germ cells and gastrulating

237 nduced oocyte-like cells were formed without specification of primordial germ cells, epigenetic repro

238 We identify a single analytical factor, the specification of prior enrichment levels, which can lead

239 nating cells using laser ablation biases the specification of progenitors toward the targeted cell ty

240 The under-specification of random effects imposes far stronger con

241 e of the nutritional microenvironment in the specification of skeletal cell fate.

242 ivin receptor ALK4 is a key regulator of the specification of somatostatin interneurons.

243 cells and then contrasts these to the unique specification of submucosal gland (SMG) cells.

244 v2, an Ets-transcription factor, governs the specification of the earliest hemato-endothelial progeni

245 This pattern depends on the specification of the eventual tallest row, then the assi

246 an existing feature graph, and potential mis-specification of the feature graph can be harmful on cla

247 lenges common to all approaches are accurate specification of the generation interval and reconstruct

248 r, these studies have not yielded a detailed specification of the infection cycle, which could provid

249 onset of the second cell-fate decision, the specification of the inner cell mass (ICM) to primitive

250 Hence, our results indicate that the specification of the laminar patterns of projection orig

251 indication for a requirement of Sox10 in the specification of the mammary placode or descending mamma

252 The combined usage of collagen membrane and specification of the meshes may ensure greater predictab

253 nce for a requirement for notch signaling in specification of the mTEC lineage.

254 f mesodermal transcriptional WNT targets and specification of the paraxial mesoderm in tail bud precu

255 ophrenia also confirmed the excess GABAergic specification of the patients' neural progenitor cells.

256 GGED 1 (JAG1) plays an important role in the specification of the prosensory region, which gives rise

257 g natural selection, thereby contributing to specification of the spike inflorescence shape.

258 onate pathway and Rac activity in regulating specification of the tendon lineage.

259 ential in dorsal neural tube progenitors for specification of these inhibitory neurons.

260 lls identified a novel role for BMP10 in the specification of this lineage from cardiovascular mesode

261 t the molecular events that govern hemogenic specification of vascular endothelial cells and the gene

262 regulatory network that controls the initial specification of vascular tissue identity.

263 SMILES representations, which are atom-bond specifications of chemical structures composing the mole

264 three approaches and for two different prior specifications of evolutionary rates based on HCoV-OC43

265 gdf6a, which give synthetically enhanced eye specification or growth phenotypes when in combination w

266 re, we outline the processes that govern LPM specification, organization, its cell fates and the infe

267 lineage, suggesting an intrathymic dendritic specification pathway.

268 defining transcription factors in regulating specification programs of innate and adaptive lymphocyte

269 cription factors, orchestrating cell lineage specification programs.

270 Pathology and ClinGen's MYH7-cardiomyopathy specifications provide relevant guidance for variant int

271 oa, DNA sequence elements involved in origin specification remain elusive.

272 ng of the signalling events regulating their specification remains incomplete.

273 ich it plays an instructive role in synaptic specification remains unknown.

274 o the regulatory mechanisms that control ESC specification, self-renewal and maintenance during diffe

275 The transcriptiona`l codes driving regional specification, solute transporter program activation and

276 mor types, it is challenging to pinpoint FUS specifications that may elicit the desired antitumor res

277 year and school-by-area fixed effects in all specifications, thereby controlling for overall trends i

278 The correct model specification, therefore, is essential for the validity

279 Chemotherapy induces BCSC specification through increased expression of pluripoten

280 ates their expression to control mesenchymal specification to cartilage and smooth muscle, coupling e

281 n emerges at the onset of embryonic prostate specification to populate the proximal region of the duc

282 ar that animals can exhibit exquisite graded specification to their movements.

283 nitor cells at position +4/5 regulates their specification toward secretory vs enterocyte lineages (b

284 Reconstruction of cell specification trajectories reveals that late-stage retin

285 ESC) germ layer specification and mesodermal specification, uncovering combinatorial effects of signa

286 evelopment in rats, for the first time, from specification until the sex determination stage in fetal

287 (EARL) specifications-using different scan durations per bed po

288 wever, the requirement for SKN-1 in endoderm specification varies widely among distinct C. elegans wi

289 n, which is an essential procedure for model specification via defining parameter values for a model.

290 ng to freely define and combine optimization specifications via Python scripts or Genbank annotations

291 The thickness specification was found to be of utmost importance.

292 scriptomic analysis revealed that BRC subset specification was predetermined in the primary B cell fo

293 termine whether prdm8 controls pMN cell fate specification, we used zebrafish as a model system to in

294 (EARL) specifications were also used for measurements of SUV in

295 A range of regression specifications were tested, in which cancer costs were m

296 ro reconstitution of human prospermatogonial specification whereby human primordial germ cell (PGC)-l

297 egulating human cortical neuron subtype fate specification, which is disrupted by a psychiatric-disor

298 n, replacing canonical PDX1-driven beta cell specification with a pathological, looping, distal enhan

299 ar programs that direct axon growth and cell specification, with activity-dependent mechanisms.

300 molecular flexibility during early cell-type specification, with broad relevance for pluripotent stem