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1 tion are risk-adverse (low sensitivity, high specificity).
2 none of the AVNRTs (90% sensitivity and 100% specificity).
3 iluminescence assay (100% sensitivity, 99.8% specificity).
4 ntially be used for genome editing with high specificity.
5 tamers often exhibit suboptimal affinity and specificity.
6 iral infection and a key determinant of host specificity.
7 n regions, whereas others displayed regional specificity.
8 and FPL, with a sensitivity of 93.7% at 95% specificity.
9 X2 to the human telomerase RNA hTR with high specificity.
10 ell types of choice based on that antibody's specificity.
11 area under the curve (AUC), sensitivity, and specificity.
12 technology because of its exquisite sequence specificity.
13 ort kinetics (K(m) and V(max)) and substrate specificity.
14 10(0) CFU/mL (1-9 CFU/mL), real-time target specificity.
15 (CI) were adjusted for assay sensitivity and specificity.
16 as9 variants have been reported that improve specificity.
17 els explain T cell sensitivity and antigenic specificity.
18 -target proteins, confirming their exquisite specificity.
19 4(+) T-cell subsets, irrespective of antigen specificity.
20 ovel GSK3beta inhibitors of high potency and specificity.
21 erent conformational stability and substrate specificity.
22 ly less demanding layer removes heterotrimer specificity.
23 characteristic curve (AUC), sensitivity, and specificity.
24 ess is inaccurate, with poor sensitivity and specificity.
25 ization was associated with long-term memory specificity.
26 seful in MFA due to its high sensitivity and specificity.
27 ts had similar sensitivity, ELISA had higher specificity.
28 nd function with little evidence of regional specificity.
29 tro methods to interrogate patients' T cells specificity.
30 at require cellular resolution and molecular specificity.
31 racy, 93% vs 72% sensitivity, and 83% vs 74% specificity.
32 s (Mtb) and to group them according to their specificity.
33 wn and novel cancer drivers with high tissue-specificities.
34 of 64 orthogonal synthetase-orthogonal tRNA specificities.
35 ression over time and more diverse cell-type specificities.
37 osome 7/10 aneuploidies (sensitivity = 0.90, specificity = 0.88), and CDKN2 family mutations (sensiti
38 redicting IDH mutations (sensitivity = 0.93, specificity = 0.88), ATRX mutations (sensitivity = 0.94,
39 = 0.88), ATRX mutations (sensitivity = 0.94, specificity = 0.92), chromosome 7/10 aneuploidies (sensi
40 inative power (AUC, 0.90; sensitivity, 0.85; specificity, 0.81) in identifying microbiologically conf
41 ients in remission with the highest level of specificity (100% in validation cohort 1 and 87.8% in va
42 al US had 20% sensitivity (one of five), 93% specificity (132 of 142), 9% positive predictive value (
45 tivity (p = 0.016) and equal 97.5% (468/484) specificity; 64% MSI-H and 73% MMR deficient tumours une
46 ence interval: 0.750-0.782; sensitivity 75%, specificity 65%) and 0.740 in the contemporary cohort (9
50 tisol levels below 3mug/dL (sensitivity 83%, specificity 82%), and 0.045mug/dL those below 5mug/dL (s
51 AUC for the region of clinically meaningful specificity (85%-100%) were used to compare the ability
52 perfusion unit/ degrees C (sensitivity 88%, specificity 89%) and less than or equal to 21 arbitrary
53 e early-stage LA with sensitivity~70-90% and specificity~90-93% through the sparse regression machine
54 40 mum yielded the best sensitivity (99.3%), specificity (91.0%), positive predictive value (98.6%),
55 h WBC levels of >=10 cells/mm(3) showed high specificity (94.5%) and was a better predictor of FA-M/E
56 structured interviews, PHQ-2 sensitivity and specificity (95% CI) were 0.91 (0.88-0.94) and 0.67 (0.6
59 od achieved very high coverage (median 99%), specificity (99.8%) and sensitivity (90% for haplotypes
60 se models allow us to characterize each TF's specificity, activity and interactions with chromatin.
61 ish ablative methods that provide the tissue specificity afforded by cis-regulatory elements and the
63 he conservation of active site structure and specificity among a sampling of plant pathogen Cdc14 hom
65 the evolution of methyltransferase substrate specificities and modification patterns in rRNA, and hig
71 , quantitative and systematic comparisons of specificity and cleavage outcomes across engineered and
72 by the vaccine display differences in their specificity and cross-reactivity dependent on pre-existi
73 resistance, and our results demonstrate the specificity and efficiency of the nanostructure as a dru
74 separation reduces the requirement for motif specificity and expands the repertoire of substrates.
76 itive periods and their regional and circuit specificity and highlight the challenge and power of suc
80 d here suggests strategies for improving the specificity and kinetics of Cas9 as a genome engineering
82 ed increasing attention due to its potential specificity and lack of adverse side effects when compar
83 has been put forward as neuroprotective, the specificity and mechanism of the inhibitor used is contr
84 tive enrichment of cTnI (<1 ng/mL) with high specificity and reproducibility, while simultaneously de
86 , including a relatively big size, imperfect specificity and restriction to DNA targets flanked by an
88 arch sheds light on the way the interplay of specificity and sensitivity in individual decision-makin
91 ication of acetic acid or Lugol iodine) lack specificity and sometimes can lead to unnecessary biopsi
92 probe in this study because it offers higher specificity and yields lower background currents than th
93 to 150 ppb lead gave a 91% sensitivity, 97% specificity, and 93% accuracy, and all the misclassified
94 les, we establish a 91.8% sensitivity, 95.2% specificity, and 94.3% accuracy of the smartphone-based
95 On template-based analyses, the sensitivity, specificity, and accuracy of (18)F-rhPSMA-7 PET were 53.
98 ty, intrasubclass specificity, intersubclass specificity, and class-wide cross-reactivity, suggesting
100 nated by insulin epitope B:9-23 (InsB(9-23)) specificity, and mutation of the key T-cell receptor (TC
102 QA) study aimed to validate the sensitivity, specificity, and reproducibility of provisional bedaquil
103 istent pharmacokinetic profiles, high target specificity, and robust antitumor activity were observed
104 sensitivity to A status, although with lower specificity, and this single biomarker provides better s
105 2018;140:3454-3460] that their potencies and specificities are related to differential protein dynami
108 the contributions of individual residues to specificity are usually poorly understood and often obsc
109 promiscuous decisions (high sensitivity, low specificity) are advantageous for cooperation when the s
112 This construct demonstrated high target specificity but displayed reduced efficacy in the presen
114 RT-aptamer interface that govern recognition specificity by a broad-spectrum antiviral aptamer, and t
115 e tools, users can visualize chemical target specificity by organ system, and implement different fil
116 assay demonstrated levels of sensitivity and specificity comparable with those demonstrated by the du
117 high sensitivity of 1 pg/mL ZIKV, desirable specificity, data storage, and geographic location surve
118 in which we now resolve, suggest that ligand specificity derives from favorable Van der Waals interac
119 bition, which has led to molecules that lack specificity due to the multiple roles of key kinases in
124 display several unusual properties, such as specificity for aggregated forms of the peptide, the abi
127 rotease legumain exhibits a strict substrate specificity for cleavage after asparagine and aspartic a
128 e recommendations achieved a sensitivity and specificity for correct treatment assignment of 99.6% an
130 lusters in a left or downward direction, the specificity for detecting "likely nonprogression" was 94
131 such as ZED1, interact with ZAR1 and provide specificity for different effector proteins, such as Hop
132 and demonstrates the importance of phenotype-specificity for discovery of asthma genes and epistasis.
133 targeted EMB because of its sensitivity and specificity for identification of myocardial pathologica
135 machine learning approach was 74%, while the specificity for LASSO was 41% and for the machine learni
136 AeOBP22 binding to fatty acids, and that the specificity for longer chain fatty acids is regulated by
137 odes, the overall PPV, NPV, sensitivity, and specificity for nonproliferative diabetic retinopathy (N
139 lls, expressing the CD4 ectodomain to confer specificity for the HIV envelope, to mitigate HIV-induce
140 8(+) T cells, sharing the same HSV-1 epitope-specificities, from infected HLA-A*0201 positive symptom
141 the competence regulon in both S. pneumoniae specificity groups with activities at the low nanomolar
142 cells interact closely and display regional specificity; however, little is known about how these co
143 s the primary determinant of tissue and host specificity; however, viral entry is a complex process r
150 ed antigen provided 96% sensitivity and 100% specificity in identifying B. microti antibody containin
151 er, hBEX3 aggregation-prone features and the specificity in interaction with tRNA fragments advocate
154 % [93%, 100%] sensitivity and 91% [84%, 99%] specificity in predicting outcome of SARS-CoV-2 pneumoni
155 rgy CT had a high sensitivity and a moderate specificity in the detection of bone marrow edema of the
156 by DNA methyltransferases with low sequence specificity, in this case EcoGII, an N(6)-methyladenosin
157 weighted by two scores, namely, DSI (Disease Specificity Index) and DPI (Disease Pleiotropy Index).
158 tial differences in the circulating antibody specificities induced by vaccination in these two canary
159 ndividual adhesin specificity, intrasubclass specificity, intersubclass specificity, and class-wide c
160 ivity patterns, including individual adhesin specificity, intrasubclass specificity, intersubclass sp
161 but a comprehensive analysis of human T-cell specificities is hindered by the diversity of HLA allele
162 s shown previously that a change in receptor specificity is a hallmark for adaptation to humans and e
163 However, the basis of DGAT2's acyl-donor specificity is not known because of the inherent challen
165 ligases and, thus, regulate their substrate specificity, ligase activity, and subcellular localizati
166 ality measures, protein essentiality, tissue specificity, localization and solvent accessibility.
167 per-resolution imaging depends on high label specificity, making removal of excess dye essential.
168 Despite such an elevated degree of molecular specificity, many clinically employed and experimental t
173 mcfDNA-Seq had moderate sensitivity and high specificity, NPV, and PPV for pulmonary IMI after HCT, p
174 ons, reaching accuracies, sensitivities, and specificities of 84% and 86%, 84% and 87%, and 81% and 8
175 e printed as a microarray to examine binding specificities of lectins, anti-ganglioside antibodies, a
176 entral role in RNA function, the RNA-binding specificities of most RBPs remain unknown or incompletel
179 findings highlight the remarkable functional specificities of two highly similar CDC42 splice variant
181 e study reported a sensitivity of 0.82 and a specificity of 0.70 for 2 office-based blood pressure me
182 an AUC of 0.89, a sensitivity of 0.86, and a specificity of 0.82 in differentiating clinically diagno
183 nsitivity of 0.89 (95% CI, 0.85 to 0.92) and specificity of 0.89 (95% CI, 0.85 to 0.93) to detect dem
185 ingle-reader performance had sensitivity and specificity of 52% and 77% and 67% and 74%, respectively
186 4% (microscopic diagnosis), with a tolerable specificity of 66.2% for the decision support algorithm
188 0.86 95% CI 0.79-0.04) with sensitivity and specificity of 77% and 74% and 73% and 87%, respectively
190 f 90% (95% confidence interval, 81%-95%) and specificity of 85% (95% confidence interval, 71%-93%).
191 howed a sensitivity of 67% (95% CI, 60-71%), specificity of 86% (95% CI, 75-93%) and an AUC of 0.78,
193 yielded accuracy of 84%, sensitivity of 82%, specificity of 93%, positive predictive value of 86%, an
195 ved sensitivity to 100% while having a lower specificity of 95.2% using a set of investigational anti
196 I: 80-93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93-98%), We also demonstrate
197 an average sensitivity of 91,41% and average specificity of 98,18% suggests it is potentially a viabl
198 ments within adjacent loci and safeguard the specificity of action of promoters and enhancers towards
204 furtherly confirmed the superior sensitivity/specificity of developed nanosystem toward rapid identif
206 sed a set of natural peptides to explore the specificity of dissolved extracellular wastewater peptid
211 acterize protein LLPS due to the variety and specificity of information that can be obtained about in
212 NK cell lineage influences the magnitude and specificity of interactions with host cells infected wit
213 sis includes multiple substances, the opioid specificity of interventions may limit their ability to
214 he mechanism(s) that enforce the distinctive specificity of intrinsic Xase for its biological substra
215 ontributions is critically important for the specificity of many proteases, but this balance is not y
216 bioload (growth conditions, time of growth, specificity of microbial characterization) are barriers
217 tes (ADCs), which harness the high targeting specificity of monoclonal antibodies (mAb) with the pote
219 tative proteomics to reveal the dynamics and specificity of Parkin-dependent ubiquitylation under end
220 ccessory factor that switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutama
222 tial question is whether the sensitivity and specificity of procalcitonin levels enable the practitio
223 ults indicate that the diversity and central specificity of pSNs and MNs are regulated by a common se
225 s, were not affected by tDCS, confirming the specificity of stimulation effects to movement sensation
226 There remains uncertainty about the true specificity of tests such as smear and Xpert-like tests
234 rks, yet the mechanisms governing how tissue specificity of their function is achieved are poorly und
236 ain B cells and plasma cells but the antigen specificity of these intratumoral B cells is not well un
238 al imaging in humans can distinguish laminar specificity of visual circuit plasticity in humans.
239 performance characteristics (sensitivity and specificity) of relevant pathogen-specific RDTs, we used
240 and hydrogen peroxide (H(2) O(2) ) with high specificity on a basis of domino reactions on the benzot
242 lostridioides difficile infection (CDI) lack specificity or sensitivity, which has led to guideline r
243 yV resistant to a monoclonal Ab (mAb), whose specificity overlapped the endogenous anti-VP1 response.
245 ally, the LrS induced the expression of dual specificity phosphatase 1 (DUSP1), activating transcript
246 ted a seroprevalence range maximising either specificity (positive for both tests) or sensitivity (po
249 edisposition genes estimated as sensitivity, specificity, positive predictive value (PPV), and negati
250 rveillance system to assess its sensitivity, specificity, positive predictive value, and negative pre
251 to evaluate the classifier for sensitivity, specificity, positive predictive value, negative predict
252 ariables and factors, including sensitivity, specificity, potential cross-reactivity and cross-protec
253 y form representations at multiple levels of specificity, potentially facilitating a broad range of f
256 [difference, 15.2%; 95% CI, 3.7% to 26.7%]), specificity (prostate cancer: 64.0% vs 36.0% [difference
257 ycobacterial EHs may have a narrow substrate specificity providing a potential explanation for the ge
263 g and the decision aid, requests for greater specificity regarding patient-specific cost, and challen
265 esign, and found further support for emotion specificity: Sadness, but not disgust, increased self-re
267 rved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group diffe
268 how here that DIPs/Dprs segregate into seven specificity subgroups defined by binding preferences bet
269 ts that is consistent with DNMT3A and DNMT3B specificity suggesting that DNA methylation patterns are
270 ns of Cys69 with alanine or serine show 5hmC-specificity that mirrors the hydrogen bonding potential
271 cells and achieve substrate selectivity and specificity through the interaction of distinct regulato
272 PZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with
274 find that the SNF2 domain couples substrate specificity to an ATPase step essential for DNA methylat
275 deleted cyclin Ds, which activate and confer specificity to CDK4/6, can compensate and proliferate.
277 genomes where zinc fingers are prevalent and specificity transitions would be limited in alternative
279 NA-binding domains (RBDs) and assessed their specificities using high-throughput RNA-SELEX (HTR-SELEX
280 isease 2019 (COVID-19)-infected patients and specificity using 1,204 samples submitted for routine se
282 s 93% (95% confidence interval, 80%-98%) and specificity was 82% (95% confidence interval, 68%-91%).
283 95% CI, 22.2%-59.2%) with DBT (P = .001) and specificity was 86.7% (95% CI, 84.8%-88.4%) vs 97.4% (95
285 sitivity was 93% (262/282 [95% CI, 89-95%]); specificity was 97% (593/610 [96-98%]) among participant
289 o investigate the transcriptomic basis of EC specificity, we analyzed single-cell RNA sequencing data
290 Using unprecedented spatial sensitivity and specificity, we were able to confirm the heterogeneity o
292 threshold (GMI >= 0.5), LFA sensitivity and specificity were 96.9% (31/32) and 98% (98/100), respect
293 the other organism targets, sensitivity and specificity were as follows: 100% each for Cryptococcus
295 detection of high-risk PDR, sensitivity and specificity were higher when using UWF images (87% [95%
298 esented a superior lesion detection rate and specificity when compared with visual interpretation by
299 ciated optical and electron signal at a high specificity, with an interspace of ~41 angstrom of micro
300 omain containing 8 (PNPLA8)), possesses sn-1 specificity, with polyunsaturated fatty acids at the sn-