ライフサイエンスコーパス: speckle

1 sharpness and the temporal coherence to the speckle.

2 rojection due to coherent artifacts, such as speckle.

3 ntly labeled single molecule from background speckle.

4 KSHV ORF57 also induces nuclear Ago2 speckles.

5 I and RNA processing factors within splicing speckles.

6 on of chromosomes, k-fibers, and microtubule speckles.

7 the size, stability, and dynamics of nuclear speckles.

8 e speckle-type POZ protein (SPOP) to nuclear speckles.

9 es by utilising the remarkable properties of speckles.

10 hat we validated here as enriched in nuclear speckles.

11 een them, indicate they associate at nuclear speckles.

12 horylated SC35, which is retained in nuclear speckles.

13 rms UBC26-RFA4-receptor complexes in nuclear speckles.

14 hock (HS), irrespective of their distance to speckles.

15 the importance of genome organization around speckles.

16 splicing of the IAV M transcript in nuclear speckles.

17 the viral replication complexes with nuclear speckles.

18 Here, we report that the PML-NB protein Speckled 110 kDa (Sp110) is SUMO1-modified and undergoes

19 teristic subnuclear KSHV microdomains ("LANA speckles"), a hallmark of KSHV latency.

20 protein 39 (RBM39) and localizes to nuclear speckles adjacent to spliceosomes.

21 interferometric detection technique based on speckle-analysis for remote detection is presented in th

22 from short transcripts accumulate in nuclear speckles and are bound to Nxf1.

23 SMAR1 is enriched in nuclear splicing speckles and associates with the snRNAs that are involve

24 Accumulation of HIPK2 in nuclear speckles and association with promyelocytic leukemia pro

25 per, we describe the statistics of objective speckles and demonstrate how the optical system is desig

26 1 with a SINE deletion forms diffuse nuclear speckles and is frequently translocated to the cytoplasm

27 uitment and may allow mRNAs to leave nuclear speckles and properly dock with the nuclear pore.

28 is based on correlation of X-ray near-field speckles and represents a significant broadening of the

29 ts update older proteomic studies of nuclear speckles and should provide a useful reference dataset t

30 xes traffic to and accumulate within nuclear speckles and that these steps precede the completion of

31 mbrane-less organelles (specifically nuclear speckles) and of organelle heterogeneity on splicing par

32 on with Pi04089, its localization to nuclear speckles, and its increased accumulation when co-express

33 PCBP1 to colocalize in SC35-positive nuclear speckles, and the two proteins interact in the variable

34 Although the image sharpness and speckle are related to both coherence parameters, our re

35 ical substrate Gli3, suggesting that nuclear speckles are hotspots of ubiquitination.

36 Splicing speckles are observed nearby within the lining channel s

37 Since nuclear speckles are storage sites for splicing factors, which l

38 Given that nuclear speckles are storage sites for splicing factors, which l

39 ansgene are approximately twofold higher for speckle-associated alleles 15 min after HS.

40 Nascent transcript level fold-increases for speckle-associated alleles are 12-56-fold and 3-7-fold h

41 trong preference for HIV-1 to integrate into speckle-associated genomic domains.

42 rginine with lysine in synthetic and natural speckle-associated MCDs abolishes these activities, iden

43 uggesting the possibility of conservation of speckle-associated regions.

44 MCDs can synergize with a speckle-associated RNA recognition motif to promote spec

45 ral Hsp70 flanking genes also correlate with speckle association at 37 degrees C.

46 eased nascent transcript levels accompanying speckle association correlate with reduced exosome RNA d

47 Speckle association together with chromatin decondensati

48 ent transcript levels increase/decrease with speckle association/disassociation.

49 Furthermore, we have extended the proposed speckle-based fly-scan phase tomography into the previou

50 Recently, the X-ray speckle-based imaging technique has attracted widespread

51 ilising a fly-scan mode for near field X-ray speckle-based phase tomography.

52 Recently, an X-ray speckle-based technique has shown great potential for X-

53 at intermediate distance (HSPH1) to nuclear speckles but shifting even closer with transcriptional i

54 f stimulated emission and do not suffer from speckle, but are rather broadband and have a relatively

55 ted the translocation of M1 to SC35-positive speckles, but did not interfere with PB2 localization to

56 ive genes reproducibly position near nuclear speckles, but the functional significance of this positi

57 clear organelles including nucleoli, nuclear speckles, Cajal bodies, as well as in the clusters of he

58 surement of the optical properties where the speckle can severely distort the information.

59 SmD1b resides in nucleoli and nucleoplasmic speckles, colocalizing with the splicing-related factor

60 analogue previously shown to affect nuclear speckle composition, we unexpectedly found that it also

61 fy key sequence determinants of MCD-promoted speckle condensation and link the dynamic material prope

62 dered mixed-charge domains (MCDs) in nuclear speckle condensation.

63 r with SUMO1 and SUMO2 into enlarged nuclear speckles containing polyadenylated RNA.

64 n (i.e., cerebral blood volume); and a laser speckle contrast (LSC) channel for imaging perfusion (i.

65 Speckle contrast analysis of small-angle scattering meas

66 ectral width of the light source affects the speckle contrast both experimentally and through numeric

67 idth that results in a significantly reduced speckle contrast compared with ideal narrow band lasers.

68 in which synchronized dual wavelength laser speckle contrast imaging (DWLS) was used as a guiding to

69 r tool which transmits high-resolution Laser Speckle Contrast Imaging (LSCI) directly onto the eyepie

70 Here, we present Laser Speckle Contrast Imaging (LSCI) for real-time assessment

71 The use of laser speckle contrast imaging (LSCI) has expanded rapidly for

72 mmercial fundus camera into a low-cost laser speckle contrast imaging (LSCI) system for contrast-free

73 Functional performance of laser speckle contrast imaging (LSCI) systems is compromised b

74 7) has direct cerebrovascular effects, laser speckle contrast imaging (LSCI) was performed to measure

75 in neurovascular coupling, we combined laser speckle contrast imaging with simultaneous electroenceph

76 A particular focus is put on laser speckle contrast imaging, with its current and future in

77 oducing inverse variance in conjunction with speckle contrast in Matlab-based program code.

78 We show that the speckle contrast in scattering from water depends on the

79 Speckle contrast is related to the dynamics of the scatt

80 s known that the laser coherence affects the speckle contrast, it is generally neglected in in vivo L

81 ted light narrower than ~1 nm to improve the speckle contrast.

82 Here, we report coherent resonant X-ray speckle correlation analysis, which directly determines

83 inside a dynamic scattering medium having a speckle correlation time as short as 5.6 ms, typical of

84 efficiency and spatial proximity to nuclear speckles could explain this counterintuitive behavior.

85 n in the transverse view displayed increased speckle decorrelation.

86 In contrast, RV longitudinal systolic speckle-derived strain measures were significantly diffe

87 Speckle-derived strain of the right ventricle (RV) was u

88 Speckle-derived strain reveals a heterogenous pattern of

89 RV longitudinal systolic speckle-derived strain was assessed in the basal, mid, a

90 e of a large correlation window to track the speckle displacement.

91 cally significant shifts in relative nuclear speckle distances in pair-wise comparisons between human

92 ); however, these moderate shifts in nuclear speckle distances tightly correlate with changes in cell

93 o large spliceosome assembly factor-positive speckle domains within the nuclei.

94 enes moving small mean distances relative to speckles during cell differentiation or a physiological

95 ned the formation and composition of nuclear speckles during stress induction with tubercidin, an ade

96 nuclear bodies precedes formation of nuclear speckles during telophase.

97 The increased visibility provided by speckle elimination reveals white matter fascicles and c

98 ugh arginine leads to enhanced condensation, speckle enlargement, decreased splicing factor mobility,

99 tionary competition among optical modes, the speckle field develops a single, high intensity focus si

100 and systemic hyperoxia in mice using a laser speckle flowgraphy (LSFG-Micro).

101 ced cerebral oligemia, we used in vivo laser speckle flowmetry and multimodal imaging.

102 times (tens of seconds) approaching those of speckle fluorescence methods.

103 sing process degrades the image quality with speckle formation.

104 t source with unprecedented brightness for a speckle-free and narrowband light source.

105 Speckle-free full-field imaging is demonstrated using th

106 pulsed random laser for fiber-optic sensing, speckle-free imaging, and laser-material processing, but

107 including random lasers, light storage, and speckle-free imaging.

108 que will provide a unique solution for a low-speckle, full-field, and coherent imaging in optically s

109 predicts that the distance between genes and speckles has a considerable effect on the mRNA productio

110 ngth fundus autofluorescence (SW-AF) images, speckled hyperautofluorescence and mottling indicated ma

111 e information can be extracted from a single speckle image, the spatial resolution is deteriorated du

112 high-speed camera acquires the time-varying speckle images.

113 This inducible speckle imaging (ISI) technique allows 3D speckle micros

114 fusion measurement with intraoperative laser speckle imaging and mean arterial blood pressure (MAP) r

115 blood flow was measured using multi-exposure speckle imaging at 6, 48, and 120 h post-occlusion.

116 sing longitudinal 2-photon and multiexposure speckle imaging in mice of both sexes.

117 e used in vivo multiphoton microscopy, laser speckle imaging of CBF, and electrophysiological recordi

118 Laser-speckle imaging showed that the penumbra of cerebral isc

119 ase modulation was implemented for the lower speckle imaging with over a 50% speckle reduction withou

120 ecorded with intravital microscopy and laser speckle imaging.

121 oes not preclude conventional imaging before speckle imaging.

122 translates into a 40% remaining signal after speckle imprinting and provides a rule of thumb in selec

123 We predict theoretically that speckle imprinting using photobleaching is optimal when

124 ss induces the release of SF3B1 from nuclear speckles in a manner that depends on FANCI and on the ac

125 lasmic staining in neurons and labeled large speckles in cerebellar Purkinje cells.

126 ion, suggesting an important role of nuclear speckles in gene expression regulation.

127 g negative charge abolishes condensation and speckle incorporation.

128 ts undergo length-dependent condensation and speckle incorporation.

129 identical arrangement of the characteristic speckles inside the particles.

130 s-correlation analysis of frames returns the speckle intensity autocorrelation function, g2(t), from

131 beam from the crystal evolves from a highly speckled intensity pattern into a single, bell-shaped sp

132 the inhibitors resulted in dispersal of the speckles into smaller foci with subsequent apoptosis ind

133 ique in which the displacement of near field speckle is tracked using a digital image correlation alg

134 HIV-1 transport to nuclear speckles is dependent on the interaction of the capsid p

135 pping suggests that gene distance to nuclear speckles is more deterministic and predictive of gene ex

136 p TNNT3 pre-mRNA, driving it outside nuclear speckles, leading to an altered SC35-mediated splicing.

137 splicing particle localization into nuclear speckles leads to a disproportionate enhancement of mRNA

138 V 3'UTR redistributes DDX3X and IKK-alpha to speckle-like cytoplasmic structures shown to be SGs.

139 h DDX3X and IKK-alpha, which redistribute to speckle-like cytoplasmic structures shown to be stress g

140 e exclusive protein nuclear localization and speckle-like distribution.

141 Speckle-like interference, arising in the presence of di

142 tive and negative regulators for the nuclear speckle localization of a long noncoding RNA, MALAT1, su

143 ) splicing factors and appearance of nuclear speckle-localized HIN1 during low water potential (psi(w

144 ay that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bodies and

145 ay that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bodies, and

146 diamond-anvil cells experiment, in which the speckle method was used as melting detection technique.

147 stripe and skyrmion phase using a soft X-ray speckle metrology technique.

148 Using fluorescent speckle microscopy (FSM), differential interference cont

149 Fluorescent speckle microscopy revealed that rates of actin assembly

150 le speckle imaging (ISI) technique allows 3D speckle microscopy to be performed in readily available

151 ast relative to classic (random) fluorescent speckle microscopy.

152 l vorticity or net polymerization rates from speckle microscopy.

153 urbulent quantum gas and a traveling optical speckle might burgeon into an exciting research field in

154 values were computed by using the Lagrangian speckle model estimator.

155 hypoautofluorescent (mild diffuse, moderate speckled, moderate diffuse, or advanced), or (3) hyperau

156 Here we show speckle-modulating OCT (SM-OCT), a method based purely o

157 e we present a novel neuroimaging technique, speckle-modulating optical coherence tomography (SM-OCT)

158 tions such as Gaussian noise, Poisson noise, speckle noise and pupil location error, which would larg

159 ical coherence tomography (OCT) suffers from speckle noise due to the high spatial coherence of the u

160 light manipulation that virtually eliminates speckle noise originating from a sample.

161 wever, it also causes unavoidable background speckle noise thus degrades the image quality in traditi

162 ncoherent, resulting in negligible amount of speckle noise upon decryption.

163 skin-features that are otherwise obscured by speckle noise when using conventional OCT or OCT with cu

164 uence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on

165 d digital focusing, can effectively suppress speckle noise, enhance resolution and contrast, and reve

166 ing techniques have been applied to suppress speckle noise.

167 Nuclear speckles (NS) are among the most prominent biomolecular

168 ing, a patchy pattern of hypoautofluorescent speckles on SW-FAF, and intact retinal layers on spectra

169 In elongating spermatids, CnnT forms speckles on the giant mitochondria that are required to

170 order correlations in the resulting plasmon speckle pattern assuming statistically stationary and is

171 adventitial surface by tracking motions of a speckle pattern using a custom panoramic digital image c

172 n, the magnetic domains in [Co/Pd] produce a speckle pattern, a unique fingerprint of their nanoscale

173 instein condensate and a propagating optical speckle pattern.

174 Our straightforward analysis of laser speckle patterns across the first order phase transition

175 ated wavefronts, and the resulting intensity speckle patterns in the transmitted light are acquired o

176 overcome this limitation, we project random speckle patterns instead of discrete spatial frequencies

177 Speckle patterns resulting from the interference of mult

178 We measure MDM by cross-correlating speckle patterns throughout magnetization processes.

179 unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution

180 ting sphere to generate wavelength-dependent speckle patterns, in combination with algorithms based o

181 roduction rate, with genes located closer to speckles producing mRNA at higher levels, emphasizing th

182 The Speckled Protein (SP) family of chromatin 'readers' in h

183 ed proteins, respectively, are known nuclear speckle proteins, including proteins that we validated h

184 proach successfully identified known nuclear speckle proteins.

185 tively, our results demonstrate that nuclear speckles provide an architectural basis for nuclear homi

186 aptured at different angles are fused into a speckle-reduced composite image.

187 nal OCT or OCT with current state of the art speckle reduction methods.

188 or the lower speckle imaging with over a 50% speckle reduction without a significant degradation in t

189 ocation to the nucleoplasm and SC35-positive speckles, respectively, even though CLUH is usually cyto

190 Laser Speckle Rheology (LSR) offers a novel, non-contact optic

191 pecies, English sole (Parophrys vetulus) and speckled sanddab (Citharichthys stigmaeus).

192 e wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a

193 In summary, the potential of the remote speckle sensing technique for photoacoustic detection is

194 fluorescent speckles significantly improves speckle signal and contrast relative to classic (random)

195 inting of three-dimensional (3D) fluorescent speckles significantly improves speckle signal and contr

196 splicing factors are concentrated in nuclear speckles, some of which occur at highly active transcrip

197 plexes and splicing processes within nuclear speckles (specific type of non-membrane-bound organelles

198 -associated RNA recognition motif to promote speckle specificity and residence.

199 positive; 96% of ANA positives had a nuclear speckled staining pattern.

200 sed-wave tissue Doppler and RV 2-dimensional speckle strain.

201 de future experimental dissection of nuclear speckle structure and function.

202 luding U2AF65B, U2A', and U2AF35A in nuclear speckles, suggesting SFPS might be involved in the 3' sp

203 r for loop apexes mapping closest to nuclear speckles, suggesting the possibility of conservation of

204 ructures are always present, such as nuclear speckles that contain RNA-binding proteins (RBPs) and po

205 e show that the influenza virus uses nuclear speckles to promote post-transcriptional splicing of its

206 e show that influenza virus utilizes nuclear speckles to promote post-transcriptional splicing of its

207 we reveal a functional subversion of nuclear speckles to promote viral gene expression.

208 we reveal a functional subversion of nuclear speckles to promote viral gene expression.

209 -arginine (SR) proteins from nuclear storage speckles to the nucleoplasm for splicing function, depho

210 r (RS) domains, mobilizing them from storage speckles to the splicing machinery.

211 on indices were obtained using 2-dimensional speckle tracking (2DCPA; TomTec, Germany).

212 sis, validation data of two-dimensional (2D) speckle tracking (2DST) echocardiography myocardial stra

213 work is hardware vendor independent and uses speckle tracking (endocardial border detection) on ultra

214 Using two-dimensional echocardiography and speckle tracking analysis, this study compared LV mechan

215 ean age, 47.4+/-9.9 years) were eligible for speckle tracking analysis.

216 Together, these data support speckle tracking as a postprocessing echocardiographic t

217 spectively compared echocardiographic GLS by speckle tracking at presentation with ICI myocarditis (c

218 using 2D normalized cross-correlation based speckle tracking can address this issue, however, only i

219 diography with myocardial strain measured by speckle tracking during the Year-25 examination (age, 43

220 Speckle tracking echocardiography (STE), and more recent

221 All patients underwent 2-dimensional speckle tracking echocardiography and cardiovascular mag

222 advanced imaging modalities, including both speckle tracking echocardiography and tissue tracking by

223 and recalling multidimensional attributes of speckle tracking echocardiography data sets derived from

224 The speckle tracking echocardiography data were normalized i

225 me myocardial perfusion echocardiography and speckle tracking echocardiography imaging.

226 gly support the routine use of 2-dimensional speckle tracking echocardiography in the evaluation of y

227 Using only speckle tracking echocardiography variables, associative

228 cular alterations were monitored by advanced speckle tracking echocardiography, gene expression analy

229 of rigid body rotation, using 2-dimensional speckle tracking echocardiography, in young patients wit

230 te) phases were analyzed using 2-dimensional speckle tracking echocardiography.

231 Techniques of 2-dimensional speckle tracking enable the measurement of myocardial de

232 (RA late LS rate) phases were assessed by 2D speckle tracking in 65 patients with PAH, 6-minute walk

233 We applied single-molecule speckle tracking in live fission yeast to directly measu

234 nges of left ventricular functions including speckle tracking in patients with diabetes who were free

235 We measured GLS by 2-dimensional speckle tracking in the apical 4-chamber view in 791 par

236 Low GLS measured by 2-dimensional speckle tracking predicts future cardiovascular events i

237 hod is based on the recently developed X-ray speckle tracking technique in which the displacement of

238 tolic global longitudinal strain by means of speckle tracking was assessed with same-day transthoraci

239 Rotational strain measured by speckle tracking was compared in 32 children after OHT,

240 action (EF) by planimetry and peak GLS by 2D speckle tracking were available at admission in 115 of 1

241 onventional ultrasonography, two-dimensional speckle tracking, and cardiac magnetic resonance (CMR) T

242 ography including tissue-Doppler imaging and speckle tracking, and cardiovascular magnetic resonance.

243 The speckle tracking, border detection and model fitting met

244 Speckle tracking-based deformation as a feasible and sen

245 diography with myocardial strain measured by speckle tracking.

246 and time-based dyssynchrony were assessed by speckle tracking.

247 ch could be estimated and corrected using 2D speckle tracking.

248 using 2D normalized cross-correlation based speckle tracking.

249 We performed speckle-tracking analysis of echocardiograms from partic

250 We performed speckle-tracking analysis on HyperGEN (Hypertension Gene

251 lobal longitudinal strain was measured using speckle-tracking analysis.

252 After adjusting for speckle-tracking analyst, image quality, study site, age

253 rial-Cardiac Resynchronization Therapy) with speckle-tracking data available.

254 machine-learning framework that incorporates speckle-tracking echocardiographic data for automated di

255 Expert-annotated speckle-tracking echocardiographic datasets obtained fro

256 e hypothesis that contractile function using speckle-tracking echocardiographic global circumferentia

257 LS was assessed by 2-dimensional speckle-tracking echocardiography at baseline in 447 pat

258 All patients underwent speckle-tracking echocardiography for measurement of lef

259 We assessed LA function measured by speckle-tracking echocardiography in 357 patients with H

260 This review appraised speckle-tracking echocardiography in a clinical context

261 ures of regional longitudinal deformation by speckle-tracking echocardiography predict ventricular ta

262 nal echocardiography is challenging, whereas speckle-tracking echocardiography RV free wall longitudi

263 +/- 0.6 cm, P = 0.163), and two-dimensional speckle-tracking echocardiography was used to assess LV

264 easures study design using 2-dimensional and speckle-tracking echocardiography was used to examine ac

265 n-based imaging techniques (and specifically speckle-tracking echocardiography) have been shown to ha

266 ing at mitral valve opening (%untwMVO) using speckle-tracking echocardiography, (2) coronary flow res

267 V mechanics were assessed with 2-dimensional speckle-tracking echocardiography, and region-specific a

268 y foster the implementation of 2-dimensional speckle-tracking echocardiography-derived RV analysis in

269 l strain were calculated using 2-dimensional speckle-tracking echocardiography.

270 ardiac deformation was assessed in detail by speckle-tracking echocardiography.

271 deformation was assessed by two-dimensional speckle-tracking echocardiography.

272 py as well as conventional and 2-dimensional speckle-tracking echocardiography.

273 e reference values for RVLS by 2-dimensional speckle-tracking echocardiography; and (2) their relatio

274 ion was assessed by LV ejection fraction and speckle-tracking GLS.

275 e, tricuspid annular plane excursion, and RV speckle-tracking longitudinal strain.

276 In particular, we discuss the use of speckle-tracking strain in selected areas, such as undif

277 tients without AF history were evaluated by (speckle-tracking) echocardiography.

278 Here we reveal that the E3 ubiquitin ligase Speckle-type BTB-POZ protein (SPOP) restrains the inflam

279 Multiple studies have confirmed that speckle-type pox virus and zinc finger (POZ) protein (SP

280 ng cyclin D-CDK4-mediated phosphorylation of speckle-type POZ protein (SPOP) and thereby promoting SP

281 tate cancer-specific somatic mutation in the Speckle-Type POZ protein (SPOP) gene.

282 The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulat

283 3 ubiquitin ligase substrate-binding adaptor speckle-type POZ protein (SPOP) is the most frequently m

284 e show that recurrent PC-driver mutations in speckle-type POZ protein (SPOP) stabilize the TRIM24 pro

285 assemblies influences the recruitment of the speckle-type POZ protein (SPOP) to nuclear speckles.

286 Previous in vitro studies suggested that Speckle-type POZ protein (Spop), part of the Cullin-3 (C

287 nd degradation of XBP1s by the Cullin3-SPOP (speckle-type POZ protein) E3 ligase complex.

288 y, we find an increase in hnRNP K in nuclear speckles upon IAV infection, which may alter accessibili

289 vestigate the cilia-driven flow field and 3D speckle variance imaging to investigate size and extent

290 Speckle variance OCT-A allows visualization and quantifi

291 trometry (MS) to compare proteins in nuclear speckles versus centromeres.

292 ally, lncRNA and RBP localization to nuclear speckles was disrupted, exon junction complex (EJC) recr

293 Using this speckle wavemeter as part of a feedback loop, we stabili

294 t T1L, but not T3D, mu2 localizes to nuclear speckles, where it forms a complex with the mRNA splicin

295 a protein variant that localizes to nuclear speckles, where it targets a cell mRNA splicing factor.

296 and link the dynamic material properties of speckles with function in mRNA processing.

297 orrelates inversely with distance to nuclear speckles, with chromosome regions of unusually high expr

298 ci already preposition very close to nuclear speckles, with the remaining positioned near or at inter

299 3 fused with green fluorescent protein forms speckles within minutes in response to higher temperatur

300 of species' habitat associations, using the speckled wood butterfly, Pararge aegeria, in Britain, as