ライフサイエンスコーパス: speculation

1 this effect, which has long been a matter of speculation.

2 cross-coupling reactions-has been subject to speculation.

3 has therefore been the subject of particular speculation.

4 ERK signal transduction is still a matter of speculation.

5 y bowel disease (IBD) is the subject of much speculation.

6 s in most species, has long been a matter of speculation.

7 arbon on Mars have been a subject of intense speculation.

8 oducing enzyme system(s) remains a matter of speculation.

9 to be put to rest with solid science and not speculation.

10 eta to memory remains the subject of intense speculation.

11 ringia has long been subject to research and speculation.

12 rons have been the subject of much study and speculation.

13 lls in these species has remained a topic of speculation.

14 effect has remained elusive and a subject of speculation.

15 g areas of current interest, contention, and speculation.

16 al decay in aging humans remains a matter of speculation.

17 ecificity in malarial ADAs is the subject of speculation.

18 ein molecular docking studies supported this speculation.

19 of education would be needed to confirm this speculation.

20 biotic biosynthesis has been subject to much speculation.

21 ting preference shifts is just an intriguing speculation.

22 eptions has been the subject of considerable speculation.

23 a molecule that has been the center of much speculation.

24 mportant aspects of ancient exchange open to speculation.

25 tient care and hospital costs is a matter of speculation.

26 understood, despite much experimentation and speculation.

27 rning RuBisCO evolution have been limited to speculation.

28 ry bypass grafting (CABG) are the subject of speculation.

29 e 6-hydroxyl groups, has been the subject of speculation.

30 elated stimuli are seeking to validate these speculations.

31 nd behavior has been the subject of numerous speculations.

32 Based on these speculations, a growing number of husbandry recommendati

33 Although speculation abounds regarding ongoing decay and looming

34 at little is known has prompted much hopeful speculation about a generalized mechanistic thread that

35 Decades of speculation about a warmer, wetter Mars climate in the p

36 osperms forms the mechanistic foundation for speculation about how angiosperms drove sweeping ecologi

37 We end our commentary by offering some speculation about how Pessoa's arguments naturally exten

38 Speculation about how to successfully resolve these issu

39 and form the main thrust of this paper, with speculation about other disciplines and emphasis that al

40 regulated cell death in bacteria have led to speculation about possible benefits that apoptosis-like

41 adicts the caregiver-stress model and raises speculation about selection bias influencing these findi

42 Hence, our data help to resolve speculation about the "apparent" loss of this fraction f

43 image the human brain have provoked excited speculation about the application of neuroscience to oth

44 the location of functional receptors, allows speculation about the circuits that make use of these re

45 There has been much speculation about the functional role of Src in colorect

46 lying ssRNA-capsid co-assembly, and inspires speculation about the links between nucleoprotein comple

47 only fragments of these complexes, inspiring speculation about the overall protein assembly and confo

48 These results suggest that the widespread speculation about the prevalence of exposure to untrustw

49 Speculation about the source of contamination has been w

50 Increasing speculation about the use of histone deacetylase (HDAC)

51 There has been much speculation about their age, but progress in dating cact

52 ession of most targeted proteins, leading to speculation about their role in the variability, or nois

53 976 as periodic recertification emerged, and speculation about what certification might look like in

54 poral requirements for SMN in mice, renewing speculation about when and where repletion of SMN is nec

55 d messenger diacylglycerol, which has led to speculation about whether a different second messenger a

56 from Hungary in 1242 CE, has generated much speculation and an array of controversial theories.

57 th its size and duration, and there has been speculation and concern regarding the potential for EBOV

58 These findings culminate 50 years of speculation and debate concerning the chlamydial anomaly

59 ession changes--has long been the subject of speculation and debate.

60 inant causes of price increases are investor speculation and ethanol conversion.

61 onary and developmental biologists, yielding speculation and hypotheses concerning their putative hom

62 follow a similar pattern of experimentation, speculation and marginalization.

63 re of eukaryotic cells, was long shrouded in speculation and mystery.

64 sorting out reliably established facts from speculations and unsubstantiated claims.

65 croRNA clusters has been the subject of much speculation, and a selective advantage of clusters of fu

66 as been the subject of investigative effort, speculation, and controversy.

67 implicated this region in dyslexia and some speculations are made in this regard.

68 These intriguing findings provoke speculation as to how a cell decides to undergo either a

69 wn to have more than 100 CPR genes, inviting speculation as to the functional importance of this larg

70 of its geographical localization and allows speculation as to the worldwide spread of the virus, ver

71 This has generated interest and speculation as to their function during infection.

72 blastoma cell line to facilitate preliminary speculation as to where highly malignant tumours might f

73 riguing observation only adds to the current speculation as to whether or not MOFs may find a role as

74 It remains a matter of speculation as to whether the sense CUG-containing RNA a

75 Though there are many speculations as to its function, based solely on sequenc

76 tudied over the past few decades, leading to speculations as to the mechanism by which stripes, spots

77 he defects caused by aneuploidy and end with speculations as to whether and how aneuploidy, despite i

78 ation of CMs that are not polyploid, and (e) speculations as to why CMs become polyploid at all.

79 s, which indicates that contrary to previous speculations, ASPM and MCPH1 have not been selected for

80 lculations and corroborate the long-standing speculation based on theoretical calculations in previou

81 Current interpretation of indirect data and speculations based on theoretical considerations are inc

82 value of STEM education involve substantial speculation because they ignore the impacts of economic

83 nsal rodents are the subject of interest and speculation but accurate data are rarely available.

84 , which is a subject that has attracted much speculation but little scholarship.

85 Why this is so remains in the realm of speculation but may have its origins in the maternal imm

86 ism of its biosynthesis invited much initial speculation but was finally clarified by the discovery o

87 on zoonotic disease risk are the subject of speculation, but lack a coherent framework for understan

88 bre axons have made them the subject of much speculation, but little experimental progress for the pa

89 imprinting changes, there has been extensive speculation, but no robust evidence, that imprinted gene

90 Fitness landscapes are the subject of much speculation, but their structure is essentially unknown.

91 ions have long been a source of interest and speculation, but there is very little structural informa

92 ith global warming has long been a topic for speculation, but was never addressed using a climate mod

93 Thus, contrary to earlier speculation, C5l2 is a functional receptor rather than m

94 Speculation can produce many plausible scenarios, but ou

95 amate transporter, VGLUT3, has brought about speculation concerning its role and function based on it

96 Speculation concerning the influence of metabolic rate o

97 Speculation concerning the neurobiobehavioral substrates

98 There is considerable speculation concerning the role of the ubiquitous antiph

99 sks and systems has prompted an expansion of speculations concerning the function of the cerebellum.

100 ng with phenomena such as rhetorical intent, speculations, contradictions and negations.

101 While speculation exists about the role of O-GlcNAc in neurode

102 haracterizes a process known as neoteny, and speculation exists over whether it has contributed to th

103 spite an obvious link to a petroleum source, speculation exists that biogenic sources also contribute

104 otent progestin in the horse ends decades of speculation, explaining how equine pregnancies survive w

105 ased on either preliminary data or plausible speculation extending from findings in the existing lite

106 ted in these mammals has been the subject of speculation for decades.

107 ir action has been the subject of unresolved speculation for over five decades.

108 e stability after cervical hemisection raise speculation for potentially diverse roles in modulating

109 l movement have been the subject of vigorous speculation for several decades.

110 Here, we examine such speculation from the perspective of the functional prope

111 Speculation has long revolved around whether more primit

112 Speculations have been made that the wrack accumulating

113 a systematic investigation of such enticing speculations impossible.

114 ntly a subject of much research interest and speculation in terms of host health.

115 There has been some speculation in the literature that formation may occur f

116 s exciton state has long been the subject of speculation in various model systems(2,3), and examples

117 If this speculation is correct, then one should see more O(2)(*)

118 ce on the brain are largely unknown, and any speculation is inferred from heroin and methadone studie

119 One speculation is that neurons in motor cortex reflect this

120 One speculation is that the brain employs neuromodulatory sy

121 One speculation is that the mutant Atp13a2(Isoform-1) protei

122 To further confirm this speculation, it is necessary to develop a systematic kno

123 Despite much speculation, it is unknown whether endoplasmic reticulum

124 e of FET3 repression by Izh2p is a matter of speculation, it provides a reporter with which to probe

125 Despite much speculation, it remains unclear which RO element(s) acco

126 well established; and although an appealing speculation, its role in fostering the evolution of MGUS

127 of which are current targets of considerable speculation, may be nothing more than indirect by-produc

128 Despite much speculation, no direct evidence has been presented to re

129 seemingly paradoxical occurrence has led to speculation of a 'Janus mutation' in RET that causes ove

130 nd other rock-derived nutrients has fostered speculation of a direct link between N fixation and mine

131 in the hydrologic cycle has even led to the speculation of a disturbance "tipping point" leading to

132 here (SH) field morphology and has motivated speculation of an impending reversal.

133 erneurons (CCK(+)VGluT3(+)INTs) has prompted speculation of GABA/glutamate corelease from these cells

134 rs orbit showed localized patches, prompting speculation of sources from subsurface bacteria or nonbi

135 This has prompted speculation of what their influence would be on habitabi

136 al ice reductions in the future, have fueled speculations of potential new trans-Arctic shipping rout

137 o ethanol in the United States, and investor speculation on commodity markets lead to widely differin

138 f patients with brain metastases and provide speculation on future research directions.

139 pleiotropy of the Notch pathway can confound speculation on possible segmentation mechanisms in the l

140 Furthermore, some speculation on the biosynthesis of prenylated bruceol de

141 We also review recent speculation on the evolution and adaptive value of white

142 This finding invites speculation on the future role of metabolic imaging for

143 improve discussion sections by shifting from speculation on the impact of sources of error to quantif

144 s in the immune response and provide further speculation on the putative mechanisms by which LAP may

145 presented based on these findings, allowing speculation on the putative role of Nin88 in muro.

146 artemisinin tolerance/resistance has led to speculation on their continued long-term effectiveness.

147 iable between individual synapses, prompting speculation on their specific relationship, and on the p

148 mune disease mechanisms, allowing fact-based speculation on their therapeutic potential.

149 derstanding of how anti-VEGF agents work and speculation on when to implement them clinically for neo

150 We provide some speculation on why detecting GxE in a genome-wide associ

151 I conclude with speculations on further developments and a comment on th

152 This finding confirms previous speculations on the 'ventral pathway of somatosensory pe

153 These observations prompted our speculations on the common developmental and evolutionar

154 okine signaling will be summarized, and some speculations on the significance and implications of the

155 Speculation over the role of screening will continue unt

156 close association with egg clutches leads to speculation over the type and extent of care exhibited b

157 There has been speculation over whether borderland cultures such as Gre

158 Much speculation persists regarding bat evolution; however, l

159 The speculation pictures calsequestrin polymers as 'wires' t

160 Speculation prompted a reisolation of spiroleucettadine

161 mmetry have been the subject of considerable speculation; proposals for the advantages associated wit

162 eir existence was initially pure theoretical speculation, recent years have seen several experimental

163 y be generalized to other arthropod species, speculation regarding the antiviral function of EVE-deri

164 involved in apoptosis, leading to extensive speculation regarding the evolution of apoptosis.

165 , the tailed bacterial viruses, have brought speculation regarding the existence of an evolutionary r

166 on a double logarithmic plot has led to much speculation regarding the number and nature of the criti

167 There has been much speculation regarding the origin of this aberration in s

168 The results invite speculation regarding the potential exploitation of this

169 zation at the atomic scale, and substantiate speculation regarding the role of defects controlling th

170 H(4+) 4 Cl(-) provides a starting point for speculation regarding transition-state assemblies.

171 thways, although the subject of considerable speculation, remain unclear.

172 Optimism and speculation require a counterweight.

173 uth magnetic poles--have been the subject of speculation since the first detailed observations of mag

174 Observed speculation slows convergence by impeding the process wh

175 Despite much speculation, strong evidence of the mechanisms by which

176 h these findings are in contrast to previous speculations suggesting redox mediation of electron tran

177 Speculation that a universal varicella vaccination progr

178 This has led to speculation that A30P forms aggregates that are distinct

179 There has been speculation that adolescents with anxiety are at risk fo

180 function in cultured cell models, prompting speculation that Aire-PHD:H3-tail interactions underlie

181 These findings have resulted in speculation that alterations in the gut microbiome may p

182 ined cone structure and function support the speculation that alternative pathways are critical for c

183 rupting from Saturn's moon Enceladus fuelled speculation that an internal ocean was the source.

184 ly in the mammalian liver and brain, fueling speculation that aneuploidy provides a selective advanta

185 This has led to speculation that another subset of T cells may significa

186 This has led to speculation that antioxidants like selenium (Se) may pla

187 ndoplasmic reticulum Ca(2+) stores, fuelling speculation that archetypal intracellular Ca(2+) channel

188 udies comparing several endemic sites led to speculation that as transmission decreases morbidity and

189 This discrepancy has led to speculation that autumn migration may be a critical limi

190 ved WxxxE signature sequence, leading to the speculation that bacterial G protein mimicry may result

191 There has long been speculation that barley was domesticated more than once.

192 These two points have led to speculation that BipA may be a novel regulatory protein

193 ed to be softer than nontumor cells, raising speculation that cancer cells might adaptively soften to

194 rganelles called Polycomb bodies, leading to speculation that canonical PRC1 might be found in a sepa

195 There has been growing speculation that cephalopod populations are proliferatin

196 al variation in eczema prevalence has fueled speculation that climate may modulate disease activity.

197 It is the authors' speculation that diabetes induces blood-vitreous barrier

198 th the endoplasmic reticulum (ER) has led to speculation that distribution of these two organelles is

199 form-specific homophilic binding, leading to speculation that Dscam proteins mediate cell recognition

200 ion called 'listless.' These findings led to speculation that E(2) deprivation, under these condition

201 between heart rate and lifespan, leading to speculation that elevated heart rate could significantly

202 n vegetative tissues and confirm the earlier speculation that elevating fatty acid biosynthesis in th

203 Consequently, there has been speculation that end-of-life care in the ICU represents

204 ent vasodilatation in humans, leading to the speculation that endothelial dysfunction contributes to

205 verity and remission rates in IBD has led to speculation that eosinophils may contribute to the antim

206 that of 2OH-4MeO-BP, our results invite the speculation that exposure to elevated 2,4OH-BP levels ma

207 e size of the lipid substrate has stimulated speculation that flippases use a different transport mec

208 ates in Martian soil samples has fueled much speculation that flows of perchlorate brines might be th

209 These findings validate Gelei's speculation that full-length pairing of homologous chrom

210 umulation of GHB in ssadh mutants led to the speculation that GHB is the cause of aberrant phenotypes

211 form both homo- and heterodimers, has led to speculation that GPCR dimers may be required for efficie

212 There has also been speculation that H7N9 will have few CD4 T-cell epitopes.

213 f alpha(2) and a substrate (CDP), leading to speculation that HU might intercept a transient ET pathw

214 ction with ICU end-of-life care has prompted speculation that ICU palliative care has improved over t

215 n in brains of stimulant users have prompted speculation that increasing dopamine signaling might hel

216 Despite decades of speculation that inhibiting endogenous insulin degradati

217 ) dendritic cells (DCs) in vitro have led to speculation that inhibition of AXL would promote antivir

218 nd possesses a papain-like domain, prompting speculation that it functions as a proteolytic enzyme.

219 ral product found in potato tubers, there is speculation that it inhibits sprout growth by prolonging

220 I secretion system (T6SS) was met with early speculation that it too acts as a 'needle' that pathogen

221 xposed to UV light has been observed raising speculation that lens cells themselves could act as phag

222 eral experimental studies do not support the speculation that low intracranial pressure and the resul

223 The novel addition offered here is the speculation that low-abundance, gain-of-function somatic

224 aque-substrate interface have often prompted speculation that Mefp-5 plays a key role in adhesion.

225 s derived from infected animals prompted our speculation that neutrophils modulate the proinflammator

226 standing of OFR photochemistry left room for speculation that OFR chemistry may be generally irreleva

227 e itself a piece of crowd wisdom, leading to speculation that online voting may soon put credentialed

228 tor involvement has been reported, prompting speculation that other mosquitoes such as Culex quinquef

229 This result allowed speculation that oxidation of Cys436 and phosphorylation

230 le-domain proteins by denaturants has led to speculation that protein sequences may have evolved to l

231 of buffering is qualitatively explained by a speculation that puts together ideas first proposed by o

232 are proposed to be highly mobile, prompting speculation that resistomes may not correlate with phylo

233 ns, providing evidence for the long-standing speculation that retrotransposable elements in mRNAs are

234 This research addresses public speculation that SARS-CoV-2 might be transmitted by mosq

235 s, including Alzheimer's disease, leading to speculation that sIBM pathogenesis has similarities to n

236 The review ends with speculation that sigma-bond-forming reactions may also b

237 e controversial, which has led to widespread speculation that Smo signals through a variety of novel

238 xidized from the Archean onwards, leading to speculation that such oxidation enabled atmospheric oxyg

239 There is speculation that the additional BchH homologs may regula

240 ll the experimental observations lead to the speculation that the CBPQT((2+)(*+)) ring of the bisradi

241 elial phenotype of primary tumors has led to speculation that the disseminated tumor cells recruited

242 This has led to speculation that the domains of native VAR2CSA need to c

243 The cognitive impairments lead to speculation that the dystrophin protein family may play

244 ECC) than the general population, leading to speculation that the etiology and characteristics of the

245 ts have been reported, has generated further speculation that the fungus is an opportunistic pathogen

246 ular signal transduction networks has led to speculation that the high degree of interconnectivity th

247 cells from the ciliary epithelium has led to speculation that the mammalian retina and/or surrounding

248 located in the N terminus, which has led to speculation that the protein may be autoproteolytically

249 These observations have engendered speculation that the seemingly flexible gamma(4) residue

250 of the energy is unaccounted for, leading to speculation that the unmeasured pickup ions or energetic

251 These observations have inspired speculation that the use of common skin washing techniqu

252 tal technologies by young people has spurred speculation that their regular use negatively impacts ps

253 xamined, ysrT is a separate gene, leading to speculation that there is a functional advantage to YsrT

254 However, despite speculation that these abnormalities confer an increased

255 iver, pancreas, and other tissues led to the speculation that these cells might be the source of adul

256 ion of another animal's behavior, leading to speculation that these circuits participate in sensory l

257 has yielded conflicting findings, fostering speculation that these conditions associate only in cert

258 mbrian acorn worm lived in tubes, leading to speculation that these fossils may have been pterobranch

259 is currently a matter of intense study amid speculation that these ncRNAs have key regulatory roles.

260 n in HepG2 cells which understandably led to speculation that these same vectors would be immediately

261 than 3d-block compounds, and this has led to speculation that they could be used in molecular spintro

262 f DNA methyltransferases (MTases), prompting speculation that they may be involved in the cancerizati

263 been successfully cultured, which has led to speculation that they may be obligately dependent on the

264 This has led to speculation that they may dispense with the daily clock.

265 ns that tRNAs are trimmed in both, prompting speculation that they may have developed novel alternati

266 these genes in serotonergic neurons invites speculation that they may mediate an underlying disease

267 n and frequency of conical cells have led to speculation that they play a role in attracting animal p

268 There is evidence and speculation that this cultural transmission of behavior

269 orm colloidal aggregates, and there has been speculation that this may affect the absorption and dist

270 oimmunity and infectious disease, as well as speculation that this mechanism may be responsible for t

271 vidence have proved inconclusive, leading to speculation that this mechanism might not occur.

272 ion factors encoded in its genome has led to speculation that this organism may be unusually reliant

273 condary vector, Aedes albopictus, leading to speculation that this was a major factor in expansion.

274 , and psychophysical experiments, has led to speculation that V1 activity has a special or direct rol

275 Indeed, there has been speculation that viral membranes form de novo in cytopla

276 e and non-Hodgkin lymphoma (NHL) have led to speculation that vitamin D may protect against lymphomag

277 rminal sterile alpha-motif (SAM), leading to speculation that Yan/TEL1 polymers may spread along chro

278 Some population genetics studies have led to speculation that, until recently, this species constitut

279 These findings have led to speculations that cohesin ring-like structures normally

280 The findings support speculations that music and language share mechanisms th

281 f PRM-S, provide an explanation for previous speculations that PRM-A may contain a second mannose bin

282 This has led to speculations that SARS-CoV-2 may be evolving towards hig

283 Contrary to speculation, the divergent carboxyl-terminal tail domain

284 Despite considerable speculation, the evolutionary origins of this species' r

285 Despite 80 y of speculation, the origins of these developmental patterns

286 Despite decades of speculation, the processes underlying the expansive geno

287 Despite decades of speculation, the proton pumping mechanism of complex I (

288 However, despite speculation, there is little evidence of a link between

289 n the past 50 years, this idea has gone from speculation to a prevailing idea.

290 er evolutionary potential remains an area of speculation: various keys to success have been proposed

291 Prior speculation was that local composition controlled which

292 Although they have attracted considerable speculation, we conclude that multiple trapping or hoppi

293 Finally, in contrast to previous speculation, we confirmed that acidification of the cult

294 By drawing a clear border between facts and speculations, we hope to stimulate the future research t

295 ow available, rounding off the analysis with speculation where necessary.

296 d 2010/2011 are specifically due to investor speculation, whereas an underlying upward trend is due t

297 tic-resistant bacteria is a fertile area for speculation with few defined mechanisms.

298 of either cell type has long been an area of speculation with no definitive head-to-head trial.

299 There is much speculation with regard to the potential cardioprotectiv

300 Hologenomic speciation remains testable speculation without experimental support.