ライフサイエンスコーパス: sperm

1 ence of NPD or LPD seminal plasma (devoid of sperm).

2 sis, lack of leydig cells and lack of mature sperm.

3 uncommitted germ cells give rise to haploid sperm.

4 ysing the genomes of thousands of individual sperm.

5 enomic data across major somatic tissues and sperm.

6 ed primary spermatocytes rather than haploid sperm.

7 ial endocarditis, and posthumous donation of sperm.

8 of all sperm and 41% of progressively motile sperm.

9 terrelationship between these two enzymes in sperm.

10 gh in immotile compared to motile epididymal sperm.

11 ased BMI accelerates the epigenetic aging in sperm.

12 ella on elongating spermatids and epididymal sperm.

13 from one male can directly benefit a rival's sperm.

14 efficiently partition chromosomes to produce sperm.

15 of these siRNAs to reinforce TE silencing in sperm.

16 and the impact of BMI on epigenetic aging in sperm.

17 ermy, or fertilization of an egg by multiple sperm.

18 s tailored to rapidly generate multitudes of sperm.

19 uring cytoplasmic ciliogenesis in Drosophila sperm.

20 ot demethylated and histones are retained in sperm(3,4).

21 Out of millions of ejaculated sperm, a few reach the fertilization site in mammals.

22 In sperm, a number of CTAs support energy generation, howev

23 men worldwide suffer from infertility, with sperm abnormalities being the most common defect.

24 s or eggs for females, and testes length and sperm activity in males.

25 ive plasma membrane ion channel CatSper, for sperm activity.

26 veal epigenetic changes in the periphery and sperm after certain exposures.

27 Sexed-sperm also revealed significantly less hyperactivated sp

28 rifugation recovers an average of 33% of all sperm and 41% of progressively motile sperm.

29 instrument recovers an average of 86% of all sperm and 82% of progressively motile sperm from the ori

30 underlying defects including a low number of sperm and abnormal sperm morphology.

31 The channel is present in zebrafish sperm and carries a proton inward current that acidifies

32 atin landscapes that are present in oocytes, sperm and early preimplantation embryos, including atypi

33 nome-wide distributions of small RNAs in the sperm and egg cells of rice.

34 The interaction of sperm and egg culminates with the fusion of their cell m

35 effects on reproductive hormones, fecundity, sperm and egg quality, egg biochemical composition and f

36 ctive performance, in terms of fecundity and sperm and egg quality, which was correlated with female

37 embryos allocate the resources stored in the sperm and egg?

38 tilization, suggesting a direct link between sperm and embryo RNA.

39 s (SSCs) are essential for the generation of sperm and have potential therapeutic value for treating

40 at selective chromatin accessibility in both sperm and MII oocytes is largely erased in early pronucl

41 suggesting differential impacts of aging on sperm and seminal fluid and trade-offs between them or,

42 fspring cardiovascular function through both sperm and seminal plasma specific mechanisms over succes

43 ffspring vascular homeostasis and define the sperm and seminal plasma specific programming effects on

44 hese results support that THC alters DNAm in sperm and that route of exposure can have differential e

45 Larger testes produce more sperm and therefore improve reproductive success in the

46 em activity and cardiovascular function in a sperm and/or seminal plasma specific manner.

47 programmed by paternal low protein diet in a sperm and/or seminal plasma specific manner.

48 success requires fully functional germline (sperm) and soma (seminal fluid) components.

49 in an offspring and evident only in father's sperm, and identified single-nucleotide, structural and

50 nteractors of MAFR-1 that are expressed in a sperm- and germline-enriched manner.

51 irst time that Strongylocentrotus purpuratus sperm are chemotactic and this response is consistent wi

52 two functional centrioles contributed by the sperm are present in the zygote.

53 calcium regulated phosphatase, in testis and sperm, are also infertile.

54 g has shown consistent epigenetic changes to sperm as a man ages.

55 mes higher in the embryos derived from sexed-sperm as compared to conventional embryos (p < 0.05) res

56 Imaging sperm as they travel through the female reproductive tra

57 es sterility due to an absence of functional sperm, as depleted animals produce arrested primary sper

58 Sperm-associated Antigen 5 (SPAG5) is a mitotic spindle

59 (THC) and nicotine on DNA methylation in rat sperm at genes involved in neurodevelopment.

60 The ability to evaluate sperm at the microscopic level, at high-throughput, woul

61 the immunological barrier and the release of sperms at spermiation take place at the opposite ends of

62 ive portfolio as well as uncover novel human sperm biology.

63 etained plugs did not completely block rival sperm but did significantly limit their numbers.

64 the advantage of using virtual staining for sperm cell analysis.

65 ertilization of an egg cell by more than one sperm cell can produce viable progeny in a flowering pla

66 and how the role of some recently discovered sperm cell surface and secreted proteins contribute to o

67 tone H3 at the same genomic location in most sperm cell.

68 lowed us to efficiently analyze thousands of sperm cells and identify correlations between dry-mass c

69 en for molecules that change the motility of sperm cells and their ability to fertilize.

70 o coordinate successful interaction with the sperm cells and their transport vehicle, the pollen tube

71 tyrosine phosphorylation (pY) development in sperm cells capacitated in vitro and in vivo.

72 aracterizing the morphology of stained human sperm cells for fertility evaluation, but, on the other

73 ARTs), as it can allow specific selection of sperm cells for in vitro fertilization (IVF).

74 Here, we investigated whether all sperm cells have a common epigenetic configuration that

75 Mammalian sperm cells must respond to cues originating from along

76 geneous retention of methylated histone in a sperm cells population.

77 eep neural network can take images of unseen sperm cells retrieved from holograms acquired without st

78 Ts; male gametophytes) carrying two immobile sperm cells that grow over long distances through the ca

79 ion signalling is, therefore, essential for sperm cells to adapt to their constantly changing enviro

80 ants that need precise regulation to deliver sperm cells to ovules for fertilization.

81 Motile male gametes (sperm cells) are an ancestral eukaryotic trait that has

82 In sperm cells, 24-nt siRNAs were spread across heterochrom

83 We demonstrate this approach for human sperm cells, as there is a well-established protocol and

84 ter for the production of specialized cells, sperm cells, using mating experiments.

85 ctively disrupting the motility of X-bearing sperm cells.

86 Sperm characteristics, oxidative stress of seminal plasm

87 g sea urchin species-specific differences in sperm chemoattractant-receptor characteristics we show t

88 n experimental paradigm for reproduction and sperm chemotaxis studies, the composition and regulation

89 rs, arising as a fundamental requirement for sperm chemotaxis.

90 H3K27me3 is globally lost from histone-based sperm chromatin in Arabidopsis.

91 ic salmon eggs fertilized with UV irradiated sperm combined with a pressure shock applied at 4700-480

92 pplemented males produced 2.9-4.6 times more sperm compared to non-supplemented males for the three s

93 mating systems with relatively high and low sperm competition are therefore likely to have driven ch

94 ervations are consistent with high levels of sperm competition in Pan Furthermore, we inferred that t

95 pawning in aggregations, with high levels of sperm competition, but also when spawning in pairs due t

96 rrying males are particularly compromised in sperm competition, resulting in reduced reproductive suc

97 asure of investment in gametes and proxy for sperm competition, we find that, while gonochoristic and

98 improve reproductive success in the face of sperm competition.

99 ning TAC1/ASNS was associated with decreased sperm concentration (rs7784118: P = 3.5 x 10(-8)).

100 Sperm concentration from semen analysis was assessed as

101 Most of the semen quality parameters (sperm concentration, motility, morphology, volume, and t

102 randomization) and semen quality parameters (sperm concentration, motility, morphology, volume, DNA f

103 stratified blocked randomization by age and sperm concentration.

104 lowing testicular spermatogenesis, mammalian sperm continue to mature in a long epithelial tube known

105 ere, we show that alterations in long RNA in sperm contribute to the inheritance of specific trauma s

106 Sperm contributes genetic and epigenetic information to

107 Sperm count (P = 0.001) and concentration (P = 0.044) in

108 There were no effects on sperm count and glucocorticoid receptor protein levels w

109 ho (gcKL) deficiency neither had a change in sperm count nor sperm motility.

110 gnificantly higher serum Inhibin B and total sperm count than men with the lowest serum Klotho concen

111 volume, DNA fragmentation, and total motile sperm count) at 6 months after randomization.

112 tility, morphology, volume, and total motile sperm count) were not significantly different between tr

113 or Klotho had low testicular weight, reduced sperm count, and sperm motility.

114 erm from 83 unique mutant mouse strains with sperm count, motility and morphology.

115 w sperm counts compared to males with normal sperm counts (P < 0.0001).

116 was significantly higher from males with low sperm counts compared to males with normal sperm counts

117 d these results has been correlated to lower sperm counts in ZIKV-infected humans.

118 nvironment of semen are potential markers of sperm cryotolerance.

119 receptor kinase has a dual role in ensuring sperm delivery and blocking polyspermy(3).

120 ghly regulated growth of the pollen tube for sperm delivery.

121 Additionally, sexed-sperm-derived embryos showed reduced survival times (haz

122 found that mitosis was commonly initiated at sperm-derived nuclei and their accompanying centrosomes.

123 role in quality control surveillance during sperm development.

124 ted offspring derived from either NPD or LPD sperm (devoid of seminal plasma) but in the presence of

125 bserved a linear inverse correlation between sperm DFI and sperm morphology and motility.

126 Further, sperm DFI was significantly higher from males with low s

127 mbryos (n = 360), embryos derived from sexed-sperm displayed significantly increased incidences of ar

128 imaging and ANN-based automatic detection of sperm distributed along the cleared female tract, we dem

129 assess the extent to which measurement of a sperm DNA fragmentation index (DFI) can predict sperm qu

130 dy determined if chronic THC exposure alters sperm DNA methylation (DNAm) and if such effects are int

131 cohort was injected with vehicle or THC, and sperm DNAm was analyzed.

132 Sperm donors had aneuploidy rates ranging from 0.01 to 0

133 the genomes of 31,228 human gametes from 20 sperm donors, identifying 813,122 crossovers and 787 ane

134 f histone with protamine for compaction into sperm during spermiogenesis.

135 cell lineage that gives rise to eggs and/or sperm each generation.

136 nts include pathogen entry into a host cell, sperm-egg fusion, and self/nonself discrimination by the

137 ther sperm protein, TMEM95, is necessary for sperm-egg interaction.

138 e proteins are known to be indispensable for sperm-egg membrane fusion: the sperm proteins IZUMO1 and

139 ll surface proteins that are responsible for sperm-egg recognition, binding, and fusion.

140 icotine and cannabis products but impacts on sperm epigenetics are poorly characterized.

141 ate dehydrogenase, calmodulin, ATP synthase, sperm equatorial segment protein 1, peroxiredoxin-5, sec

142 omatic females that transiently produce self-sperm.) Essentially all somatic sex differences in C. el

143 led mechanisms controlling commitment to the sperm fate, but how this fate is subsequently executed r

144 surface protein ADAM3, which is required for sperm fertilizing ability.

145 ts in the cilia in the fallopian tubes or in sperm flagella can cause female and male subfertility, r

146 We show that AeAmt1 is localized to sperm flagella during all stages of spermiogenesis and s

147 nineteen chemosensory signaling proteins in sperm flagella from the sea urchin Arbacia punctulata.

148 AeAmt1 expression in sperm flagella persists in spermatozoa that navigate the

149 so suffer from infertility because cilia and sperm flagella share several characteristics.

150 In the sperm flagellum, a single chemoattractant molecule can t

151 ls with low (LF; n = 6) and high (HF; n = 8) sperm freezability.

152 ied mouse strains have been cryopreserved by sperm freezing, the likelihood of cryorecovery success c

153 ured and correlated the DFI of frozen-thawed sperm from 83 unique mutant mouse strains with sperm cou

154 Microtubule sliding of dyskinetic sperm from Cfap45(-/-) mice is rescued with the addition

155 n eggs at fertilization may block additional sperm from entering.

156 s to determine the fatty acid composition of sperm from Holstein bulls with different freezability (G

157 , we found that viable embryos derived using sperm from males with high DFI (62.7 +/- 7.2% for IVF an

158 ic, and could open the door to production of sperm from other species in the mouse.

159 ority overlap in differential methylation in sperm from rats exposed to THC via injection as well as

160 of all sperm and 82% of progressively motile sperm from the original sample while removing white bloo

161 miRNA, piRNA, and tRNA) isolated from mature sperm from these samples were subjected to Illumina smal

162 investigate the effects of sexing on bovine sperm function and early embryonic development.

163 signalling processes implicated in defective sperm function, particularly those arising from genetic

164 essenger RNAs encoding proteins required for sperm function.

165 paralog, but not GSK3beta, is essential for sperm function.

166 activity against two key attributes of human sperm function: motility and acrosome reaction.

167 tarts with the fusion of the haploid egg and sperm gametes to form the genome of a new diploid organi

168 sly methylated fraction of histone H3 in the sperm genome is maintained during early embryonic replic

169 consequent decrease in catalytic activity of sperm GSK3.

170 Hipk4 mutant sperm have reduced oocyte binding and are incompetent fo

171 ody, is the center of attachment between the sperm head and tail.

172 establish HIPK4 as an essential regulator of sperm head shaping and potential target for male contrac

173 Fatty acids were extracted from frozen sperm in 1:2 (v/v) chloroform-methanol solvent, fraction

174 e formation of highly specialised cells: the sperm in males and the egg in females, each carrying the

175 dation risk can influence grandoffspring via sperm in three-spined stickleback Gasterosteus aculeatus

176 racytoplasmic sperm injection, we found that sperm incubated with EVs collected from stress-treated e

177 Using intracytoplasmic sperm injection, we found that sperm incubated with EVs

178 roduce viable offspring via intracytoplasmic sperm injection.

179 y be achieved by mechanical injection of one sperm into the ooplasm, thereby bypassing membrane fusio

180 Sperm ion channels and membrane receptors are attractive

181 Sperm lacking GSK3alpha display altered motility and are

182 Sperm lacking this protein were morphologically normal e

183 d sperm PP2B are essential during epididymal sperm maturation and during fertilization.

184 Loss of PP2B results in impaired epididymal sperm maturation and motility.

185 ogical amyloid matrix with putative roles in sperm maturation and sperm protection.

186 Following DNA compaction, further sperm maturation occurs in the epididymis.

187 Thus, EVs as a normal process in sperm maturation, can also perform roles in intergenerat

188 pididymal (downstream) pathways required for sperm maturation.

189 ve calcineurin to function during epididymal sperm maturation.

190 ng human eggs from fertilization by multiple sperm may have evolved more than 650 million years ago.

191 understandings of fatty acid composition of sperm membrane and lay a foundation for the manipulation

192 xidative stress of seminal plasma, serum and sperm membrane fatty acids, dietary intakes, anthropomet

193 thin the spermathecae, as well as throughout sperm migration along the spermathecal ducts during ovul

194 r calcium channel complexes, are pivotal for sperm migration in the female tract, implicating CatSper

195 Specifically, symbiont-induced sperm modifications cause catastrophic mitotic defects i

196 eption rates after sexing are due to altered sperm morphokinetics, decreasing the chance of sperm to

197 ganization, phenotype, evolutionary history, sperm morphology and genetic, which are usually associat

198 ar inverse correlation between sperm DFI and sperm morphology and motility.

199 including a low number of sperm and abnormal sperm morphology.

200 ounseling would benefit from the addition of sperm mosaicism assessment.

201 We measured sperm mosaicism using deep-whole-genome sequencing, for

202 e fertility due to reduced sperm numbers and sperm motility.

203 P-intensive processes in the animal kingdom: sperm motility.

204 plasma may be involved in the regulation of sperm motility.

205 ency neither had a change in sperm count nor sperm motility.

206 these changes are associated with changes in sperm motility.

207 testicular weight, reduced sperm count, and sperm motility.

208 The journey of sperm navigation towards ovum is one of the most importa

209 Semen parameters, including total sperm number per ejaculate, motility, normal morphology

210 show decreased male fertility due to reduced sperm numbers and sperm motility.

211 Relative sperm numbers in turn predicted the relative fertilizati

212 Injection of long RNA fraction from sperm of males exposed to postnatal trauma recapitulates

213 epresentation bisulfite sequencing data from sperm of rats exposed to THC via oral gavage showed that

214 The sperm of T3-overexposed male ancestors revealed signific

215 Computer-assisted semen analysis (CASA) of sperm of the same bulls (n = 5), before and after sexing

216 se plasma HIV-RNA remained <50 copies/mL had sperm or cervicovaginal lavage collected between Weeks 2

217 rental sex bias related to Cre expression in sperm or oocytes.

218 We observed that either LPD sperm or seminal fluid at conception impaired adult offs

219 es are induced either by mating itself or by sperm or seminal fluid proteins.

220 ns received in the first mating 'primed' the sperm (or the female) for this binding.

221 Fusion of an egg and sperm, or fertilization, sets off a cascade of developme

222 ion of 254 miRNA, 194 tRNA, and 937 piRNA in sperm over time.

223 lower in the embryos derived from sex-sorted sperm (p < 0.001).

224 d fast (A) and slow (B) progressively motile sperm (p < 0.05) after sexing.

225 o revealed significantly less hyperactivated sperm (p < 0.05).

226 t be accurately predicted using conventional sperm parameters.

227 We show that repeated mating reduced the sperm pool and increased the percentage of GSCs in M- an

228 arding stress in the paternal environment to sperm, potentially altering fetal development.

229 Interrelated functions of GSK3alpha and sperm PP2B are essential during epididymal sperm maturat

230 of testicular tissue allows storage of early sperm precursor cells for use in generating new individu

231 Sperm preparation is critical to achieving a successful

232 automated instrument capable of performing a sperm preparation starting with a diluted semen sample.

233 Additionally, we find that sperm production declines chronologically with age, inva

234 ies have to invest disproportionally more in sperm production than predicted not only when spawning i

235 h lagging and paired chromosomes for optimal sperm production.

236 Differences in the number of each male's sperm progressing through the female reproductive tract

237 After the intervention, mean +/- SD sperm progressive motility was greater in the DE group (

238 Previously, we have shown that human sperm Prohibitin (PHB) expression is significantly negat

239 with putative roles in sperm maturation and sperm protection.

240 logue of the mammalian NUCLEAR AUTOANTIGENIC SPERM PROTEIN (NASP) and Schizosaccharomyces pombe histo

241 organelles but fail to assemble their major sperm protein into fibrous bodies.

242 GSK3) was identified as an enzyme regulating sperm protein phosphatase.

243 Bindin is a sperm protein that mediates attachment and membrane fusi

244 didymis, which plays key roles in remodeling sperm protein, lipid, and RNA composition.

245 Here we demonstrate that another sperm protein, TMEM95, is necessary for sperm-egg intera

246 spensable for sperm-egg membrane fusion: the sperm proteins IZUMO1 and SPACA6, and the egg protein JU

247 simple, informative and reliable measure of sperm quality and can accurately predict male mouse fert

248 rm DNA fragmentation index (DFI) can predict sperm quality and fertility after cryopreservation.

249 ty, advanced diagnostic tests to investigate sperm quality and function have been developed to improv

250 gametophyte environment that is required for sperm release(4).

251 al insemination the use of sex-sorted bovine sperm results in reduced conception, the causes of which

252 Initial evidence suggested that sperm RNA is causally linked to the transmission of symp

253 low-Na(+) freshwater environment to conserve sperm's ability to depolarize.

254 From sperm samples from a 'normative' cohort of healthy human

255 hese findings provide molecular insight into sperm selection for successful fertilization in the fema

256 implicating CatSper-dependent mechanisms in sperm selection.

257 hromosomes, gametes and humans, we developed Sperm-seq, a way of simultaneously analysing the genomes

258 Recent studies have demonstrated sperm small non-coding RNA (sncRNA) populations vary in

259 that a high-sugar diet acutely alters human sperm small RNA profiles after 1 week and that these cha

260 study, we aligned repeated sampling of human sperm sncRNA expression data with concurrent measures of

261 tential environmentally responsive 'dynamic' sperm sncRNA.

262 Male mice lacking sperm-specific calcineurin (PP2B), a calcium regulated p

263 vity of H3K27me3 erasers and deposition of a sperm-specific histone, H3.10 (ref.

264 They make sperm-specific membranous organelles but fail to assembl

265 ious RNAi-based studies and discovered a new sperm-specific role.

266 al gene products are required for Drosophila sperm storage and sperm viability, and a spermathecal-de

267 One essential process is female sperm storage in specialized structures called spermathe

268 and OVCH2 was required for processing of the sperm surface protein ADAM3, which is required for sperm

269 ale Drosophila receives from a male can bind sperm that she had stored from a previous male, and resc

270 in both endosperm and embryo because the two sperms that participate in double fertilization are gene

271 Spermatogonia, which produce sperm throughout the male lifetime, are regulated inside

272 tamine proteins dramatically condense DNA in sperm to almost crystalline packing levels.

273 ation may increase vulnerability of genes in sperm to disrupted methylation.

274 is a critical and complex fluid that carries sperm to eggs to initiate the fertilization process.

275 on pollen tubes to transport their immotile sperm to fertilize the female gametophytes inside ovules

276 s of PEZO-1 also led to an inability of self-sperm to navigate back to the spermatheca properly after

277 This rapid response by sperm to nutritional fluctuation raises intriguing quest

278 erm morphokinetics, decreasing the chance of sperm to reach and fertilise the oocyte, and aberrant ea

279 is a highly regulated process that produces sperm to transmit genetic information to the next genera

280 es in the generative cell (the progenitor of sperm) to promote the second pollen mitosis, mediates si

281 -offspring of injected males and affects the sperm transcriptome in fathers and sons.

282 le-specific events during Drosophila mating: sperm transfer and a simultaneous decrease in motivation

283 les become infertile principally via reduced sperm transfer and viability.

284 es' paternity share is affected by biases in sperm use.

285 stored from a previous male, and rescue the sperm utilization and fertility defects of an SP-deficie

286 ocytes and human and Drosophila melanogaster sperm), very little is known about cytoplasmic cilia ass

287 ay indicate a conserved function for AMTs in sperm viability and reproduction in general.

288 re required for Drosophila sperm storage and sperm viability, and a spermathecal-derived heme peroxid

289 The percentage of viable frozen-thawed sperm (%ViableSperm) determined by flow cytometry varied

290 ically mate once, requiring them to maintain sperm viably to fertilize eggs they lay over their lifet

291 Furthermore, embryos derived from sexed-sperm were found to reach developmental stages at simila

292 ifferentially methylated (DM) loci in motile sperm were identified using reduced representation bisul

293 once bound to the oolemma, TMEM95-deficient sperm were unable to fuse with the egg membrane or penet

294 lopment of biological catalysts derived from sperm whale myoglobin that exploit a carbene transfer me

295 dwarf (Kogia sima) and pygmy (K. breviceps) sperm whales to examine the effects of phylogeny and lif

296 n some whale societies, including killer and sperm whales.

297 e effects of PBB on epigenetic regulation in sperm, which could explain some of the endocrine-related

298 ntial for spermatogenesis and pre-configures sperm with a chromatin state that forecasts gene express

299 ne piRNA locus on chromosome 6 (pi6) produce sperm with defects in capacitation and egg fertilization

300 Sperm with different freezability phenotypes only had a