ライフサイエンスコーパス: spermatogenic

1 CRES (cystatin-related epididymal spermatogenic), a member of the cystatin superfamily of

2 differences in cytosine methylation between spermatogenic and brain cells, identifying 223 new candi

3 criptome profiling reveals overexpression of spermatogenic and cuticle-related genes in eggd-1 hermap

4 ochondrial electron transport chain (ETC) in spermatogenic and in colon carcinoma cells, and silencin

5 G-RNAs are required for proper expression of spermatogenic and oogenic genes.

6 vealed enlarged intercellular spaces between spermatogenic and Sertoli cells as well as the spermatid

7 esis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction

8 also exhibited reduced penile length, focal spermatogenic anomalies, diminished sperm motility and s

9 y this severe phenotype, indicating that the spermatogenic arrest arises from distinct molecular path

10 le with reduced testis size, lack sperm with spermatogenic arrest at round spermatid stage and loss o

11 miwi(null) mice display spermatogenic arrest at the beginning of the round sperm

12 However, spermatogenic arrest at the pachytene spermatocyte stage

13 nt in the Arid4a(-/-)Arid4b(+/-) mice showed spermatogenic arrest at the stages of meiotic spermatocy

14 S-AR(-/y) mice were infertile, with spermatogenic arrest predominately at the diplotene prem

15 A spermatogenic arrest was also observed in all participan

16 consistently showed error-prone meiosis and spermatogenic arrest with round spermatids of type Sa as

17 ith marked calcifications in the epididymis, spermatogenic arrest, and focally germ cells expressing

18 d apoptosis, disruption of piRNA biogenesis, spermatogenic arrest, and male infertility.

19 g cell hyperplasia, apoptosis of germ cells, spermatogenic arrest, seminiferous tubule degeneration,

20 sis, leading to transposon de-repression and spermatogenic arrest.

21 ies have shown that Sox3 null mice exhibit a spermatogenic block as young adults, the mechanism of wh

22 nto Sxrb-deletion mice fails to overcome the spermatogenic block.

23 phenotype in the F1 generation of decreased spermatogenic capacity (cell number and viability) and i

24 -Kit levels could contribute to the elevated spermatogenic cell apoptosis and Leydig cell hyperprolif

25 r number of hSSLCs and an increased level of spermatogenic cell death.

26 idate the roles of the Utp14 genes in normal spermatogenic cell development as a basis for understand

27 has shown that this protein is required for spermatogenic cell differentiation in adult mice.

28 the conditional Rlim cKO specifically to the spermatogenic cell lineage largely recapitulates this ph

29 Both populations expressed the spermatogenic cell marker, DAZL, but not the somatic cel

30 that forms cell-specific complexes with rat spermatogenic cell nuclear factors distinct from cyclic

31 agnitude of heritable effects depends on the spermatogenic cell stage treated.

32 strate a strict requirement of Six5 for both spermatogenic cell survival and spermiogenesis.

33 gulation of YAP is essential for maintaining spermatogenic cell survival during the later stages of s

34 wever, the molecular evolution of individual spermatogenic cell types across mammals remains largely

35 y was measured in mixed germ cell (i.e., all spermatogenic cell types in adult testis) nuclear extrac

36 ts from premeiotic, meiotic, and postmeiotic spermatogenic cell types obtained from young mice.

37 l as RNA expression analysis using separated spermatogenic cell types revealed that Ant4 expression w

38 increased spontaneous mutant frequencies in spermatogenic cell types, AP endonuclease heterozygous (

39 ocessing regulatory sequence elements in all spermatogenic cell types.

40 hat base excision repair activity is high in spermatogenic cell types.

41 In testis, Fzd9 is expressed in all spermatogenic cell types.

42 ne by using enriched populations of specific spermatogenic cell types.

43 scripts from multiple miRNA genes in various spermatogenic cell types.

44 element binding protein 2gc (SREBP2gc) is a spermatogenic cell-enriched isoform of the ubiquitous tr

45 propose that SREBP2gc is part of a cadre of spermatogenic cell-enriched isoforms of ubiquitously exp

46 perm and regulation of F-actin dynamics by a spermatogenic cell-specific CAPZ heterodimer is essentia

47 speriolin and determined that it is a novel spermatogenic cell-specific Cdc20-binding protein, is pr

48 amilies containing paralogous genes encoding spermatogenic cell-specific isoforms, the large number o

49 Similarly, the degradation of spermatogenic cell-specific lncRNAs by piRNAs is mediate

50 MCP originated from an EDC gene and acquired spermatogenic cell-specific transcriptional and translat

51 ited significantly lower activity than mixed spermatogenic cell-type nuclear extracts, thereby sugges

52 The highest levels were observed in spermatogenic cells (but not in spermatozoa), and in neu

53 regions in both lymphoblastoid (mitotic) and spermatogenic cells (meiotic).

54 In mammals, diploid spermatogenic cells acquire the competence to initiate m

55 t Fer and FerT reside in the mitochondria of spermatogenic cells and are harnessed to the reprogramme

56 then self-renew and differentiate to produce spermatogenic cells and functional sperm from early post

57 ariant of Fer, FerT, is uniquely detected in spermatogenic cells and is absent from normal somatic ti

58 SED1 is expressed in spermatogenic cells and is secreted by the initial segme

59 -associated genes that are expressed only in spermatogenic cells and malignant cells, and the overbea

60 The Pcdp1 gene is expressed in spermatogenic cells and motile ciliated epithelial cells

61 widespread and fundamental characteristic of spermatogenic cells and Sertoli cells.

62 to the role of X chromosome inactivation in spermatogenic cells and the developmental order of molec

63 rmatozoa of these animals, even though their spermatogenic cells are destined to die (bs/bs and qk/qk

64 the peculiar patterns of gene expression in spermatogenic cells are the consequence of powerful evol

65 Here, we address this problem in vivo using spermatogenic cells as a model.

66 The Hsp70-2 gene is expressed only in spermatogenic cells at a significant level.

67 n assays with enriched populations of murine spermatogenic cells at stages prior to, during, and foll

68 sulted in male chimeras which produced sperm/spermatogenic cells bearing the mutant allele, however t

69 nce-specific RNA binding activity present in spermatogenic cells contains the two Y-box proteins MSY2

70 riched in Drosophila testes, particularly in spermatogenic cells during the early stages of spermatog

71 cells appear, plateaus as the first wave of spermatogenic cells enters meiosis (10 days after birth)

72 Spermatogenic cells exhibit a lower spontaneous mutation

73 Spermatogenic cells express cell-specific molecules with

74 Here, we show that murine spermatogenic cells express numerous endo-siRNAs, which

75 The Man2a2 null spermatogenic cells fail to adhere to Sertoli cells and

76 eculate that transcriptional derepression in spermatogenic cells favors the creation of expressed ret

77 Spermatogenic cells from 9-month-old Apex(+/-) lacI(+) m

78 However, spermatogenic cells from old lacI mice display a 10-fold

79 In addition, spermatogenic cells from old mice have significantly inc

80 gulation of this Ca2+ channel in dissociated spermatogenic cells from the mouse using the whole-cell

81 rter localizes to the plasma membrane in all spermatogenic cells from the primary spermatocyte stage

82 ous mutant frequency for a lacI transgene in spermatogenic cells from young mice suggest that base ex

83 increased mutation frequencies compared with spermatogenic cells from young or middle-aged mice.

84 cally expressed in both normal and malignant spermatogenic cells in a maturation stage-dependent patt

85 lts suggest that each ADAM is transcribed in spermatogenic cells in a regulated pattern at a specific

86 inactivating Drosha or Dicer exclusively in spermatogenic cells in postnatal testes using the Cre-lo

87 aired cell-cell contact and sloughing off of spermatogenic cells in seminiferous epithelium, and lack

88 lar epithelial cells in the renal cortex, in spermatogenic cells in the testis, and in epithelial cel

89 he inability of lentiviral vectors to infect spermatogenic cells in vivo.

90 many atypical features of gene expression in spermatogenic cells including the gross overexpression o

91 At the same time, gene expression in spermatogenic cells is rapidly evolving.

92 A paternal age effect in spermatogenic cells is recognized for the human populati

93 iptional inactivation of the X chromosome in spermatogenic cells may not be as complete as that in so

94 requency of the lacI transgene is greater in spermatogenic cells obtained from old mice, suggesting t

95 Spermatogenic cells obtained from young adult lacI trans

96 ished in vivo expression of this promoter in spermatogenic cells of transgenic mice.

97 h this proposal, patch clamp recordings from spermatogenic cells reveal an amiloride-sensitive inward

98 Immunofluorescence of spermatogenic cells revealed BRD4 in a ring around the n

99 the expression of YAP in mice testicular and spermatogenic cells suggests its role in mammalian sperm

100 Spermatogenic cells synthesize a unique 70-kDa heat shoc

101 o germ cells and somatic tissues of mammals, spermatogenic cells synthesize HSP70-2 during meiosis.

102 oposons are expressed in meiotic and haploid spermatogenic cells than in any other tissue and specula

103 entified a population of cellular mRNAs from spermatogenic cells that appear to serve as templates fo

104 Primary cultures of rat spermatogenic cells that did not bind to collagen matric

105 to promote robust meiotic gene expression in spermatogenic cells that have initiated meiosis.

106 This confers on spermatogenic cells the molecular competence to, in resp

107 s absence severely impairs the transition of spermatogenic cells through the late meiotic stages and

108 a high sensitivity of ovarian follicles and spermatogenic cells to HZE particles.

109 EIOC-YTHDC2-RBM46 enhances the competence of spermatogenic cells to initiate meiosis.

110 uding developing testes and also in purified spermatogenic cells using semi-quantitative PCR analyses

111 iogenesis in postreplicative cell types when spermatogenic cells were obtained from old mice.

112 e possible effects of these radionuclides on spermatogenic cells, a study has been undertaken to obta

113 asement membrane, degenerated Sertoli cells, spermatogenic cells, and axoneme.

114 by in situ hybridization specifically in the spermatogenic cells, and is downregulated during termina

115 n of Pabp2 mRNA in meiotic and early haploid spermatogenic cells, and the Pabp2 mRNA encodes a protei

116 attern was caused by killing differentiating spermatogenic cells, but there was little cytotoxicity o

117 led a continuous developmental trajectory of spermatogenic cells, from spermatogonia to spermatids, e

118 how that, while SEL1L is highly expressed in spermatogenic cells, it is dispensable for their differe

119 In spermatogenic cells, PR1C is still a relatively strong c

120 sues and delayed epigenetic reprogramming in spermatogenic cells, providing evidence that gonadotropi

121 nal regulation of gene expression in haploid spermatogenic cells, spermatids.

122 ulated, especially suppressed in postmitotic spermatogenic cells, to guarantee robustness of spermato

123 ch as Mili are localized in the cytoplasm of spermatogenic cells, where they are associated with a ge

124 omponent of the selenium delivery pathway to spermatogenic cells.

125 ilize the folding of Cdc20 during meiosis in spermatogenic cells.

126 ient males were derived from the transferred spermatogenic cells.

127 2, which is highly enriched in rat and mouse spermatogenic cells.

128 cytes and round spermatids relative to other spermatogenic cells.

129 Similar attrition occurred in spermatogenic cells.

130 r DND-26 also labeled the Golgi apparatus in spermatogenic cells.

131 orrelated with meiotic and early postmeiotic spermatogenic cells.

132 at is expressed in meiotic and early haploid spermatogenic cells.

133 resent at high levels in meiotic and haploid spermatogenic cells.

134 H1t is not expressed in somatic or in early spermatogenic cells.

135 due to X-chromosome inactivation in meiotic spermatogenic cells.

136 r factor binding and transgene expression in spermatogenic cells.

137 rol of mRNA fate in late meiotic and haploid spermatogenic cells.

138 MEIOC molecularly supports early meiosis in spermatogenic cells.

139 tor of the post-meiotic development of mouse spermatogenic cells.

140 in stemness maintenance of hematopoietic and spermatogenic cells.

141 expression is confined almost completely to spermatogenic cells.

142 of FireMaster, alters the epigenome in human spermatogenic cells.

143 oach reduced 1,099 proteins co-purified with spermatogenic chromatin, currently the most extensive ca

144 alysis in Caenorhabditis elegans to identify spermatogenic chromatin-associated proteins that are imp

145 neonate, pup, and adult donor testes produce spermatogenic colonies of similar size.

146 be made to various clinical states of severe spermatogenic compromise.

147 Cystatin-related epididymal spermatogenic (CRES), a reproductive cystatin and key co

148 l cystatin CRES (cystatin-related epididymal spermatogenic), cst8, a reproductive-specific member of

149 to show that during the first, prepubertal, spermatogenic cycle (i) RALDH-dependent synthesis of RA

150 of damaged paternal DNA, and that the entire spermatogenic cycle can be at risk after mutagenic expos

151 Similar rates of expansion per spermatogenic cycle in man would yield the large expansi

152 1R) that is alternatively spliced during the spermatogenic cycle in the rat testis.

153 ated in a cyclical fashion during the 12-day spermatogenic cycle of the adult rat testis.

154 roduces effects that require longer than one spermatogenic cycle to resolve.

155 here Sertoli cell function is coupled to the spermatogenic cycle.

156 y in spermatocytes and spermatids during rat spermatogenic cycle.

157 in is no longer necessary for the subsequent spermatogenic cycles but essential to spermiation.

158 The primary spermatogenic defect in Csnk2a2-/- testis is a specific

159 gonial depletion mutation (jsd), a recessive spermatogenic defect mapped to mouse chromosome 1.

160 The onset of the spermatogenic defect occurs in the first wave of spermat

161 ile (bs), a spontaneous mutation that causes spermatogenic defects and germ cell loss.

162 vealed excess triglyceride accumulation, and spermatogenic defects in bmm mutants were rescued by gen

163 stand sperm development in wildtype mice and spermatogenic defects in infertile mice.

164 DNA repair defects cause a variety of spermatogenic defects in mouse models.

165 Homozygous males are sterile and show spermatogenic defects in sperm individualization and nuc

166 ctions could readily account for the diverse spermatogenic defects observed in human males with AZF d

167 The technique also is being used to examine spermatogenic defects, correct male infertility, and gen

168 background have largely emphasized postnatal spermatogenic defects.

169 ermore, Mili and Tdrd1 mutants share similar spermatogenic defects.

170 divided into concentric layers representing spermatogenic development in the seminiferous epithelium

171 nt transcriptional states at later stages of spermatogenic development.

172 own and previously undescribed regulators of spermatogenic development.

173 gress through DNA repair-competent phases of spermatogenic development.

174 e TGCTs result from disrupted testicular and spermatogenic developmental programs.

175 cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive

176 e quantify allele-specific expression during spermatogenic differentiation at single-cell resolution

177 The decision to commit to spermatogenic differentiation coincides with the loss of

178 ing YAP expression during the early stage of spermatogenic differentiation increased the number of PL

179 ranscription factor essential for subsequent spermatogenic differentiation.

180 nic cell survival during the later stages of spermatogenic differentiation.

181 to enable TRF2 targeting to genes regulating spermatogenic differentiation.

182 n in GSC daughter cells but does not prevent spermatogenic differentiation.

183 These results indicate that the various spermatogenic disruptions associated with X heterochroma

184 sha cKO testes appeared to be more severe in spermatogenic disruptions than Dicer cKO testes.

185 The developmental course of spermatogenic disruptions was similar at morphological l

186 Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhi

187 far prevented the complete reconstruction of spermatogenic events in cell culture.

188 aintained its conserved functional motif and spermatogenic expression from insects to humans.

189 Here, we characterize in detail the spermatogenic expression of the core particle subunit Pr

190 the male population and can be due to severe spermatogenic failure (SPGF), resulting in no or very fe

191 % of men, is predominantly caused by primary spermatogenic failure (SPGF).

192 he most common known genetic cause of severe spermatogenic failure (SSF).

193 regions of the human Y chromosome results in spermatogenic failure and infertility.

194 mes, impaired meiotic progression and led to spermatogenic failure and infertility.

195 frequent cause of autosomal recessive severe spermatogenic failure and male infertility with strong c

196 pted piRNA pathway as a major cause of human spermatogenic failure and provide insights into transpos

197 issing genetic etiology in idiopathic severe spermatogenic failure and significantly reduces the know

198 with hybrid sterility in male house mice via spermatogenic failure at the pachytene stage.

199 isplay gonadal atrophy, and Atm-/- mice show spermatogenic failure due to arrest at prophase of meios

200 T4 expression in men with cryptorchidism and spermatogenic failure due to E2F1 copy number variations

201 identified in all three regions, no case of spermatogenic failure has been traced to a point mutatio

202 Histology and fertility tests confirmed spermatogenic failure in GCKO males.

203 offers a plausible mechanism to account for spermatogenic failure in patients bearing deletions of t

204 e of the significant factors contributing to spermatogenic failure in patients with non-obstructive a

205 e restriction of the associated phenotype to spermatogenic failure indicates the remarkable functiona

206 some are found in a small number of men with spermatogenic failure involving, predominantly, three re

207 ion has far lower penetrance with respect to spermatogenic failure than previously characterized Y-ch

208 of the human Y chromosome cause irreversible spermatogenic failure that presents clinically in men as

209 mes, with clinical consequences ranging from spermatogenic failure to sex reversal and Turner syndrom

210 The carrier vs non-carrier risk for spermatogenic failure was increased 8.6-fold (p=6.0x10(-

211 ment, but suffer a complete loss of fitness (spermatogenic failure) that is restored via herbivory an

212 tations in 1940 infertile men diagnosed with spermatogenic failure, 644 normozoospermic controls, and

213 ified a single-gene deletion associated with spermatogenic failure, again involving USP9Y, by re-anal

214 etions correlate poorly with the severity of spermatogenic failure, and a deletion does not preclude

215 f a critical bridge component, TEX14, causes spermatogenic failure, but the underlying reasons are un

216 l development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adreno

217 In two men with spermatogenic failure, sister-chromatid crossing-over re

218 -dose thiamin was effective in reversing the spermatogenic failure, suggesting that the absence of th

219 f1 deletion or overexpression in mice causes spermatogenic failure, the mechanism by which E2f1 influ

220 lled gr/gr, is a significant risk factor for spermatogenic failure.

221 hromosome are the most common known cause of spermatogenic failure.

222 versal, Turner syndrome, graft rejection and spermatogenic failure.

223 region, whose deletion is a common cause of spermatogenic failure.

224 r, suggesting that the USP9Y mutation caused spermatogenic failure.

225 etailed studies on human spermatogenesis and spermatogenic failure.

226 d and did not correlate with the severity of spermatogenic failure.

227 region of the human Y chromosome results in spermatogenic failure.

228 ed resection lengths experience catastrophic spermatogenic failure.

229 ctors have been described as contributors to spermatogenic failure.

230 n the Arid4a(-/-)Arid4b(+/-) mice, including spermatogenic failures and the impaired blood-testis bar

231 mature gametes that commit to an oogenic or spermatogenic fate in response to sex-determining cues f

232 s from entering meiosis and direct them to a spermatogenic fate.

233 l, we define the developmental timing of the spermatogenic first wave in opossum and delineate conser

234 lar mechanism by which NC1-peptide regulated spermatogenic function.

235 stulated notion that there is a tendency for spermatogenic functions to transfer from autosomes to th

236 of glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (GAPDHS) lacking the N-terminal domain sup

237 proximal and necessary for the regulation of spermatogenic gene expression, primarily of premeiotic a

238 Only a handful of spermatogenic genes are within this region, including on

239 hypothesis predicts a redistribution of late spermatogenic genes from the X chromosome to the autosom

240 CHD8 is required for extensive activation of spermatogenic genes in spermatogonia, necessary for sper

241 ion of seminiferous tubules and dysregulated spermatogenic genes in the testis.

242 Extracts from mixed spermatogenic germ cells displayed the greatest activity

243 regulates the cell cycle, differentiation of spermatogenic germ cells, and/or differentiation of supp

244 , critical regulator of H3K9 methylation and spermatogenic heterochromatin organization: the germline

245 te-to-spermatogonia transition and long-term spermatogenic homeostasis.

246 e factors in regulating either prior or post spermatogenic, i.e., early embryonic events.

247 rgence, relative to behavioral sterility and spermatogenic infertility.

248 yte-neuron, lactate-alanine, peroxisomal and spermatogenic lactate shuttles.

249 We propose a regulatory pathway in which spermatogenic leucine zipper 1 (SPZ1) promotes EMT throu

250 role of the RBP system in regulation of the spermatogenic lineage and may provide clues about the in

251 ies demonstrate that Foxo1 expression in the spermatogenic lineage is intimately associated with the

252 For the mammalian spermatogenic lineage, a foundational spermatogonial ste

253 es in proportion during establishment of the spermatogenic lineage, eventually comprising approximate

254 EF12) plays a key role in maintenance of the spermatogenic lineage.

255 ndent kinase partners, Cdk1 and Cdk2, in the spermatogenic lineage.

256 proliferation that is obligatory for normal spermatogenic maintenance in the adult.

257 m, but that host conditions are critical for spermatogenic maturation.

258 The kinase Fer and its spermatogenic meiotic variant, FerT, are coexpressed in

259 riphery of the seminiferous tubule where the spermatogenic niche will form, for mitotic reactivation

260 ors, but whether they exert related roles in spermatogenic or malignant cells has not been known.

261 ic wave are conserved features of vertebrate spermatogenic organisation that reflect the need for the

262 A recent examination of the mammalian spermatogenic pathway supports the view that cell fate i

263 Yq11.2 within the interval defining the AZFa spermatogenic phenotype.

264 inding of SNPC-1.3 at male piRNA loci drives spermatogenic piRNA transcription and requires SNPC-4.

265 improper euchromatization, leads to impaired spermatogenic potential.

266 of germ cells and microinjection of immature spermatogenic precursor cells.

267 of the testes-blood barrier and targeting of spermatogenic precursors suggest possible long-term impl

268 These results indicate that the whole spermatogenic process can be represented in cell culture

269 e at the foundation of the highly productive spermatogenic process that continuously produces male ga

270 differentiating spermatogonia and subsequent spermatogenic processes.

271 entiation, proliferation, and/or survival of spermatogenic progenitors.

272 obstacles to the identification of the core spermatogenic program.

273 machinery required for the activation of the spermatogenic programme of transcription.

274 Spermatogenic progression begins with spermatogonia, pop

275 deficiency globally decreases expression of spermatogenic-related genes, and single-cell transcripti

276 on localization of recombination-related and spermatogenic-related proteins suggest that the spermato

277 (2) lamotrigine or levetiracetam during the spermatogenic risk window (derived from each National Pr

278 nome, yielding previously unidentified human spermatogenic RNAs.

279 USP9Y, is the favored candidate for an early spermatogenic role.

280 n impairs the expression of many postmeiotic spermatogenic-specific as well as metabolic genes.

281 of chromatin remodeling factors in different spermatogenic stages and narrowed it down to bromodomain

282 owever, it is challenging since two adjacent spermatogenic stages are morphologically similar.

283 ino acid substitutions and new genes in late spermatogenic stages, probably facilitated by reduced pl

284 ine spermatogenesis as a model, we find that spermatogenic stem cell density is tightly regulated by

285 define an alternative and dynamic model for spermatogenic stem cell function in the mouse testis.

286 circuitry that controls progression through spermatogenic stem cell lineages, we are identifying mut

287 le phenotypes, including failure to maintain spermatogenic stem cells and failure to progress into vi

288 The identity and behavior of mouse spermatogenic stem cells have been a long-standing focus

289 plies that mutations accumulate with time in spermatogenic stem cells.

290 production or action, to achieve consistent spermatogenic suppression.

291 These findings suggest there are multiple spermatogenic targets for genomically defective sperm wi

292 yndrome present with sequels of hormonal and spermatogenic testicular failure like infertility, low t

293 Expression is limited to spermatogenic tissue, and a transcriptional GFP fusion s

294 n nonetheless be sexually transformed from a spermatogenic to an oogenic fate.

295 ults favor a model in which BRG1 coordinates spermatogenic transcription to ensure meiotic progressio

296 omatic housekeeping transcripts but lost the spermatogenic transcripts to the newly arisen CDY.

297 The seminiferous epithelial cycle and spermatogenic wave are conserved features of vertebrate

298 cycle of the seminiferous epithelium and the spermatogenic wave, respectively.

299 cycle of the seminiferous epithelium and the spermatogenic wave.

300 Spermatogenic Zip 1 (SPZ1) acts as a proto-oncogene and