ライフサイエンスコーパス: spermatogonia

1 and recover an enriched population of viable spermatogonia.

2 and overproliferation of transit-amplifying spermatogonia.

3 DMRT6 protein is expressed in late mitotic spermatogonia.

4 nction is restricted to singly isolated (As) spermatogonia.

5 rmatogonia and did not include GFRa1(+) A(s) spermatogonia.

6 lls and select for the piwil1:neo expressing spermatogonia.

7 ce are influenced by miR-221/222 function in spermatogonia.

8 MOLT-4 cells but were not expressed on human spermatogonia.

9 s containing Stra8-expressing, Sin3a-deleted spermatogonia.

10 n early germ cells, germline stem cells, and spermatogonia.

11 gonocytes and from postnatal differentiating spermatogonia.

12 genes characteristic of more differentiated spermatogonia.

13 oli cells form a niche for the proliferating spermatogonia.

14 probably originate from dedifferentiation of spermatogonia.

15 lting in the formation of testis tubules and spermatogonia.

16 romote spermatogenesis from surviving (host) spermatogonia.

17 lly expressed in prespermatogonia and Type A spermatogonia.

18 zing to punctate foci in more differentiated spermatogonia.

19 number of type A pale and centrally located spermatogonia.

20 Busulfan did not affect type A dark spermatogonia.

21 -renewal potential known as undifferentiated spermatogonia.

22 ession of Oct4, a marker of undifferentiated spermatogonia.

23 ning only Sertoli cells and undifferentiated spermatogonia.

24 is coexpressed with Oct4 in undifferentiated spermatogonia.

25 ic testes, with seminiferous tubules lacking spermatogonia.

26 between undifferentiated to differentiating spermatogonia.

27 spermatocytes differentiate from amplifying spermatogonia.

28 erential RA responsiveness found in neonatal spermatogonia.

29 ration induced by SCF in primary cultures of spermatogonia.

30 ifferentially methylated in diploid, mitotic spermatogonia.

31 t and enrich for rare somatic cell-types and spermatogonia.

32 ower than the frequency for primitive type A spermatogonia.

33 wing a strong positive signal in oocytes and spermatogonia.

34 ns of expression selectively in type A and B spermatogonia.

35 arget genes bound by CBX2 in differentiating spermatogonia.

36 t CpG-rich gene promoters in Kdm2a-deficient spermatogonia.

37 ral descended testis (CDT) showing no A-dark spermatogonia.

38 (G1/G0), during which they transition to pro-spermatogonia.

39 tal prospermatogonia to descendant postnatal spermatogonia.

40 programmes and activity of undifferentiated spermatogonia.

41 d newborn gonocytes and in a subset of early spermatogonia.

42 GFRalpha1-expressing A type undifferentiated spermatogonia.

43 transcriptional network in undifferentiated spermatogonia.

44 spermatogenesis and loss of undifferentiated spermatogonia.

45 yperplasia cells that accumulate early stage spermatogonia.

46 egulates the maintenance of undifferentiated spermatogonia.

47 esent but not translated in undifferentiated spermatogonia.

48 tivity serves as a mechanism that confers to spermatogonia a high sensitivity to DNA damage.

49 tinoic acid gene 8 (Stra8), undifferentiated spermatogonia accumulated in unusually high numbers as e

50 ong-term survival and proliferation of human spermatogonia after xenotransplant of cryopreserved imma

51 hesis that, through fragmentation, syncytial spermatogonia also contribute to stem cell function in h

52 Furthermore, mesenchymal-like spermatogonia also displayed developmentally linked DNA

53 Loss of Dmrt1 in spermatogonia also disrupts cyclical gene expression in

54 such that the mutation frequencies of type B spermatogonia and all subsequent stages of spermatogenes

55 AS in proliferating cells such as testicular spermatogonia and cells in the basal layer cells of the

56 ctive of stem cell or progenitor capacity in spermatogonia and dictates the interface of transition b

57 re exclusively transit-amplifying progenitor spermatogonia and did not include GFRa1(+) A(s) spermato

58 s pair throughout the euchromatic regions in spermatogonia and during the early phases of spermatocyt

59 s, Brca1 and Brca2 were expressed in mitotic spermatogonia and early meiotic prophase spermatocytes.

60 Alk6b is expressed in spermatogonia and early oocytes, and alk6b mutant gonads

61 Bmp7 transcripts are detected in spermatogonia and early primary spermatocytes during ear

62 ghly in gonocytes of the fetal testis and in spermatogonia and early spermatocytes in the adult.

63 s with SPAF antibody localized expression to spermatogonia and early spermatocytes in the basal compa

64 ow but detectable levels in the cytoplasm of spermatogonia and early spermatocytes.

65 Telomerase levels in undifferentiated spermatogonia and embryonic stem cells are comparable an

66 strains causes depletion of undifferentiated spermatogonia and eventual loss of all germ cells after

67 was expressed highly in a sub-population of spermatogonia and in primary spermatocytes, but was not

68 high rates of homing can be achieved within spermatogonia and in the female germline.

69 t Sox3 is expressed in A(s), A(pr) and A(al) spermatogonia and is required for spermatogenesis throug

70 dren with Klinefelter syndrome are born with spermatogonia and lose large numbers of germ cells durin

71 ifferentiated spermatogonia, differentiating spermatogonia and meiotic spermatocytes have cell physio

72 Type B spermatogonia and more advanced stages of spermatogenesi

73 , ZBTB16) was greatly elevated in both human spermatogonia and mouse gonocytes compared to somatic ce

74 e highly expressed in both prepubertal human spermatogonia and mouse gonocytes than in somatic cells.

75 tially pure populations of prepubertal human spermatogonia and mouse gonocytes were selected from tes

76 on in the testis was detected exclusively in spermatogonia and not in differentiated germ cells.

77 feration or differentiation of gonocytes and spermatogonia and possibly the somatic lineages as well,

78 visibles revealed clear distinctions between spermatogonia and postspermatogonial stages.

79 and 10.5 days after birth when type A and B spermatogonia and pre-leptotene and leptotene spermatocy

80 oping mouse testis as a model, we found that spermatogonia and precursor prospermatogonia exhibit a h

81 he numbers of A-aligned, intermediate, and B spermatogonia and preleptotene spermatocytes and their m

82 dergoing DNA synthesis, the progression of B spermatogonia and preleptotene spermatocytes through S-p

83 ucine zipper (L-GILZ) is highly expressed in spermatogonia and primary spermatocytes and controls spe

84 RPS6KA3, mainly detected in the cytoplasm of spermatogonia and prophase spermatocytes.

85 rovides a method to isolate and enrich human spermatogonia and remove malignant contamination by expl

86 lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells.

87 nexpectedly find that CaMKIV is expressed in spermatogonia and spermatids but excluded from spermatoc

88 ganisms, Xdazl RNA was also expressed in the spermatogonia and spermatocytes of frog testis.

89 , however, is expressed only sporadically in spermatogonia and spermatocytes.

90 ns, which were transcribed at high levels in spermatogonia and spermatocytes.

91 Maintenance of undifferentiated spermatogonia and spermatogenesis is dependent on tightl

92 te was found after irradiation of premeiotic spermatogonia and stem cells, whereas the frequency of m

93 sable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes.

94 c comparisons of Tert(High) undifferentiated spermatogonia and Tert(Low) differentiated spermatogonia

95 at homologous recombination is restricted to spermatogonia and that it immediately ceases when they b

96 through the transit amplification of diploid spermatogonia and the expression of early meiotic marker

97 ing ovarian follicles, and in the nucleus of spermatogonia and to a lesser extent in spermatoctyes, b

98 tene spermatocytes differentiate from type B spermatogonia and traverse the blood-testis barrier (BTB

99 ctive process that originates from stem cell spermatogonia and ultimately results in formation of mat

100 restricted to gonocytes and undifferentiated spermatogonia and was absent in tubules of W/W(v) mutant

101 By contrast, cyclin A2 was expressed in spermatogonia and was most abundant in preleptotene sper

102 aberrant differentiation of undifferentiated spermatogonia and with hyperactivity of Ras signaling pa

103 histone marks is dynamic and is manifest at spermatogonia and/or pre-leptotene-stage cells, which fa

104 to isolate EpCAM+/HLA-ABC-/CD49e- (putative spermatogonia) and EpCAM-/HLA-ABC+/CD49e+ (putative MOLT

105 ytoplasm of testicular germ line stem cells, spermatogonia, and early spermatocytes, where it is enri

106 ession were in the germ line stem cells, the spermatogonia, and in highest levels in preleptotene spe

107 ressed in both KIT negative and KIT positive spermatogonia, and overlap Ngn3/EGFP and SOX3 expression

108 the testis, specifically in Sertoli's cells, spermatogonia, and pachytene spermatocytes, but not in p

109 SSEA4(+) hSSCs and differentiating c-KIT(+) spermatogonia, and performed validation studies via immu

110 initial differentiation and meiotic entry of spermatogonia, and thus in the initiation of spermatogen

111 Spermatogonia are adult germline stem cells that can bot

112 Testis histology showed rainbowfish spermatogonia are large (> 10 mum) and stain positive fo

113 First, progenitor spermatogonia are prevented from responding to RA by cat

114 we demonstrate that undifferentiated type A spermatogonia are the cells that activate NOTCH signalin

115 Spermatogonia are the self-renewing, mitotic germ cells

116 H was expressed in gonocytes, type A, Int, B spermatogonia as well as in pre-Sertoli cells and Leydig

117 rmatogonia to develop into chains of aligned spermatogonia at the 8-, 16-, and 32-cell stages.

118 and normalizes the pool of undifferentiated spermatogonia between Plzf (+/+) and Plzf (lu/lu) mice,

119 lutely required for mitotic proliferation of spermatogonia but does not regulate their differentiatio

120 testis, expression of p19(Arf) is limited to spermatogonia but is extinguished completely in spermato

121 ed via FACS that EpCAM is expressed by human spermatogonia but not MOLT-4 cells.

122 The RNA helicase DDX5 is expressed by spermatogonia but roles in spermatogenesis are unexplore

123 stematic search for genes expressed in mouse spermatogonia, but not in somatic tissues.

124 were shown to stimulate formation of aligned spermatogonia, but principally to only the 4- and 8-cell

125 the proliferative activity of GFRa1(+) A(s) spermatogonia, but their progeny were exclusively transi

126 All testes contained spermatogonia, but we observed a progressive decline in

127 d spermatogonia and Tert(Low) differentiated spermatogonia by RNA sequencing reveals marked differenc

128 In conclusion, although some Bsg KO spermatogonia can undergo normal progression to the sper

129 Deleting Geminin from spermatogonia causes complete sterility in male mice.

130 roliferate and differentiate into oogonia or spermatogonia cells.

131 kers), and (3) (in older juveniles) abundant spermatogonia committing to gametogenesis (high KIT(+)).

132 stem cell signaling in the undifferentiated spermatogonia compartment, consistent with self-renewal

133 Here we show that Plzf-expressing spermatogonia completely lack monomethyl-H3-K27 and mono

134 ble mutant phenocopies single mutants, i.e., spermatogonia continue to proliferate but do not differe

135 In the presence of dorsomorphin, the spermatogonia continued to express the germ-cell markers

136 By contrast, the transit-amplifying spermatogonia cysts display similar transcriptomes, sugg

137 r than BOULE in prenatal germ stem cells and spermatogonia; DAZL also is expressed in female germ cel

138 Expression of TCF17 increases as spermatogonia differentiate into spermatocytes, indicati

139 s, ~500 genes undergo APA when proliferating spermatogonia differentiate into spermatocytes, producin

140 genesis in the mammalian testis, stem cells (spermatogonia) differentiate into spermatocytes, which s

141 Thus, compared with undifferentiated spermatogonia, differentiating spermatogonia and meiotic

142 establish that the effects of RA in vivo on spermatogonia differentiation are indirect, via SC, but

143 Importantly, our study shows that spermatogonia differentiation depends upon the ATRA synt

144 Spermatogonia differentiation does not proceed beyond th

145 Gmnn(-/-) spermatogonia disappear during the initial wave of mitot

146 bited increased DNA damage and cell death in spermatogonia, disorganized apical ectoplasmic specializ

147 Epithelial-like spermatogonia displayed the expected imprinting patterns

148 oss of all germ cells after undifferentiated spermatogonia drop below a critical threshold.

149 germ cells resulted in the loss of GSCs and spermatogonia due to the accumulation of reactive oxygen

150 Although spermatogonia enclosed by cyst cells in which the functi

151 Second, a smaller subset of undifferentiated spermatogonia enriched for SSCs exhibit catabolism-indep

152 naffected, proliferating and differentiating spermatogonia exhibit delayed cell cycle progression and

153 Gmnn(-/-) spermatogonia exhibit more double-stranded DNA breaks th

154 matogenesis, in particular spermatocytes and spermatogonia, exhibited increased rates of apoptosis.

155 e selection acting on adult self-renewing Ap spermatogonia experiencing the rare mutation could not b

156 emains similar to normal rat testes, because spermatogonia fail to differentiate into spermatocytes t

157 lack of a culture system to maintain viable spermatogonia for long periods of time.

158 providing a germline-selective advantage to spermatogonia for the recurrent mutations in the recepto

159 and de-differentiation (where interconnected spermatogonia fragment into pairs while moving towards t

160 maternal allele of the imprinted H19 gene in spermatogonia from juvenile ICSI-derived male mice.

161 loss is associated with the delayed exit of spermatogonia from the mitotic cell cycle, leading to th

162 Microarray analysis of isolated spermatogonia from Zfp145-null mice before testis degene

163 novel important factor for undifferentiated spermatogonia function and spermatogenesis.

164 indicate that the PAX7+ subset of A(single) spermatogonia functions as robust testis stem cells that

165 n p53R172H testes and the formation of giant spermatogonia (GSG) following persistent DNA damage in p

166 of intense molecular genetic investigation, spermatogonia have remained largely unexplored at the mo

167 ChIP-seq in mouse THY1(+) spermatogonia identified 4176 PLZF-bound and 2696 SALL4-

168 nitiate differentiation of A aligned into A1 spermatogonia; (ii) RARA in SC mediates the effects of R

169 d the interactions between somatic cells and spermatogonia, illuminating the mechanisms that regulate

170 successful isolation and cryopreservation of spermatogonia in an Australian rainbowfish.

171 Moreover, spontaneous cell death of spermatogonia in EndoG heterozygous mutant mice is signi

172 in early germ cells, germline stem cells and spermatogonia in insects, and its expression promotes sp

173 profiles suggest three broad populations of spermatogonia in juveniles: (1) epithelial-like spermato

174 it is not known whether adult self-renewing spermatogonia in long-term culture can generate such ste

175 marker of a rare subpopulation of A(single) spermatogonia in mice.

176 Importantly, proliferation of spermatogonia in Nxf2(-/Y) mice is significantly decreas

177 found to be expressed by stem and progenitor spermatogonia in prepubertal and adult mouse testes.

178 esulted in the reduction of undifferentiated spermatogonia in spermatogenesis, suggesting that FANCB

179 is strongly expressed by a subset of type A spermatogonia in the basal part of the seminiferous epit

180 thereby maintaining germ line stem cells and spermatogonia in their proliferative state.

181 Studies with type A spermatogonia in vivo and in vitro have indicated that S

182 s was further identified in undifferentiated spermatogonia in vivo.

183 sion in mouse PM cells in vitro and neonatal spermatogonia (including SSCs) co-cultured with T-treate

184 SALL4 regulatory targets in undifferentiated spermatogonia, including SSCs, which will help elucidate

185 ous deletion of Dmrt1 in beta-TrCP-deficient spermatogonia increased meiotic cells with a concomitant

186 222 (miR-221/222) in mouse undifferentiated spermatogonia induces transition from a KIT(-) to a KIT(

187 d Ago4 knockout mice and show that Ago4(-/-) spermatogonia initiate meiosis early, resulting from pre

188 m an arrest of entry of the undifferentiated spermatogonia into S phase; and (3) retinoid signaling r

189 d B spermatogonia, the entry of intermediate spermatogonia into their next S-phase as type B cells, a

190 close to those obtained in mice after acute spermatogonia irradiation using other systems for mutati

191 Correct function of spermatogonia is critical for the maintenance of spermat

192 ion of testis stem cells, a subset of type A spermatogonia, is critical to our understanding of their

193 ifferentiation in vivo is direct through the spermatogonia itself, and provide the first evidence tha

194 atterns, but, surprisingly, mesenchymal-like spermatogonia lacked imprinting specifically at paternal

195 Inactivation of Huwe1 in differentiating spermatogonia led to their depletion and formation of fe

196 SCs) are a subpopulation of undifferentiated spermatogonia located in a niche at the base of the semi

197 nesis, including the stem/progenitor pool of spermatogonia, markers of differentiation, potential reg

198 is known of the molecular mechanisms whereby spermatogonia, mitotic germ cells of the testis, self-re

199 an homologs of nanos3 are expressed in early spermatogonia, no study has defined the role of nanos3 i

200 e Geminin gene (Gmnn) is deleted from either spermatogonia or meiotic spermatocytes.

201 y germ cells, resembling stem cells or early spermatogonia or oogonia, but lack later stages of germ

202 in highly expressed in PGCs, fail to develop spermatogonia or oogonia.

203 P-positive donor cells had the appearance of spermatogonia or spermatocytes and expressed VASA.

204 was inactivated globally or conditionally in spermatogonia, or mis-expressed in spermatogonia, sperma

205 nto cells that strongly resemble the state 0 spermatogonia originally defined in the infant and adult

206 in sperm can arise from defective stem cells/spermatogonia, our findings raise concerns that occupati

207 Furthermore, undifferentiated spermatogonia overexpressing miR-221/222 are resistant t

208 d by microdissection, whereas Sertoli cells, spermatogonia plus early spermatocytes, pachytene sperma

209 rm-cell-specific and expressed in premeiotic spermatogonia, plus another 21 germ-cell-specific autoso

210 Spermatogenic progression begins with spermatogonia, populations of which express distinct mar

211 sion of cell cycle genes in undifferentiated spermatogonia post-transcriptionally and is required for

212 ale, Zpg protein localizes to the surface of spermatogonia, primarily on the sides adjacent to the so

213 ZIKV preferentially infected spermatogonia, primary spermatocytes and Sertoli cells i

214 mutant testis there was a marked decrease in spermatogonia proliferation during postnatal development

215 ellular pathways regulating undifferentiated spermatogonia proliferation, differentiation, and surviv

216 ytes, plasma cells, renal tubule epithelium, spermatogonia, prostatic secretory epithelial cells, ute

217 Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH

218 me course of Brca2 expression was delayed in spermatogonia relative to Brca1.

219 en though the population of undifferentiated spermatogonia remains similar to normal rat testes, beca

220 proliferation of stem-like undifferentiated spermatogonia remains unaffected.

221 to meiosis is controlled in male germ cells (spermatogonia) remains poorly understood.

222 onia or gonocytes, precursors for oocytes or spermatogonia, respectively.

223 ally, but in males, there is degeneration of spermatogonia resulting in the virtual absence of sperm.

224 In the testis, a subset of spermatogonia retains stem cell potential, while others

225 erm cells and can result in sterility, PAX7+ spermatogonia selectively survived, and their subsequent

226 ng in healthy adult mice revealed that PAX7+ spermatogonia self-maintained and produced expanding clo

227 During puberty, undifferentiated spermatogonia sequentially expand and differentiate prio

228 Pro-spermatogonia (SG) serve as the gateway to spermatogenes

229 starvation by eliminating transit-amplifying spermatogonia (SG) while maintaining a reduced pool of a

230 I, 14 of the 22 autosomal genes expressed in spermatogonia showed no decrease in expression in meioti

231 These results identify Plzf as a spermatogonia-specific transcription factor in the testi

232 s used at various stages of spermatogenesis (spermatogonia, spermatocytes and round spermatids) and t

233 s of its inactivation in the differentiating spermatogonia, spermatocytes and spermatids.

234 onally in spermatogonia, or mis-expressed in spermatogonia, spermatocytes or spermatids, neither sper

235 es are required for mitotic proliferation of spermatogonia, spermatocytes undergoing genetic recombin

236 The coordinated maturation of spermatogonia, spermatocytes, and spermatids suggests th

237 tween Sertoli cells and germ cells including spermatogonia, spermatocytes, haploid spermatids, and sp

238 ferentiation program and sequentially become spermatogonia, spermatocytes, spermatids, and eventually

239 A total of 452,095 tags derived from type A spermatogonia (Spga), pachytene spermatocytes (Spcy) and

240 GE data on the transcriptome of mouse type A spermatogonia (Spga), pachytene spermatocytes (Spcy), an

241 The transcriptomes of mouse type A spermatogonia (Spga), pachytene spermatocytes (Spcy), an

242 at around one month of age, suggesting that spermatogonia stem cells are also affected by the mutati

243 s and spermatids but not in undifferentiated spermatogonia, strongly suggesting that, similar to Bam,

244 ls is the inability to distinguish them from spermatogonia that are committed to differentiation.

245 entify a novel population of Ngn3-expressing spermatogonia that are essential for efficient testicula

246 self-renew and differentiate into progenitor spermatogonia that develop into mature spermatozoa.

247 anipulating Jak-STAT signaling, we find that spermatogonia that have initiated differentiation and ar

248 re replaced by adult dark (Ad) and pale (Ap) spermatogonia that make up the spermatogonial stem cell

249 SSCs self-renew or differentiate into spermatogonia that proliferate to give rise to spermatoc

250 Spermatogonia that reside at the basal compartment of th

251 S-phase, the division of intermediate and B spermatogonia, the entry of intermediate spermatogonia i

252 protein-expressing A(single) (GFRa1(+) A(s)) spermatogonia, the major source of male germ-line stem c

253 expression is a hallmark of undifferentiated spermatogonia, the mitotic population where germline ste

254 ning the undifferentiated state of mammalian spermatogonia through repression of KIT expression.

255 Establishment of spermatogonia throughout the fetal and postnatal period

256 which together direct the differentiation of spermatogonia throughout the male reproductive lifespan.

257 rmatogonia in juveniles: (1) epithelial-like spermatogonia (THY1(+); high OCT4, ID4, and GFRa1), (2)

258 d GFRa1), (2) more abundant mesenchymal-like spermatogonia (THY1(+); moderate OCT4 and ID4; high mese

259 uring spermatogenesis, from two-cell diploid spermatogonia to clusters of 64 post-meiotic haploid spe

260 mulate primary cultures of rat type-A single spermatogonia to develop into chains of aligned spermato

261 ermatogenesis, followed by failure of type A spermatogonia to differentiate, resulting in adult male

262 ccurs with the transition from proliferating spermatogonia to differentiating spermatocytes, with >30

263 quired for the transition from proliferative spermatogonia to differentiating spermatocytes.

264 yte, followed by the change from the mitotic spermatogonia to early meiotic spermatocyte.

265 is, meiotic SEs are preprogrammed in mitotic spermatogonia to ensure the unidirectional differentiati

266 associated with the progression from mitotic spermatogonia to meiotic spermatocytes.

267 increasing expression from gonocytes/type A spermatogonia to pachytene spermatocytes.

268 Loss of Dmrt1 causes spermatogonia to precociously exit the spermatogonial pr

269 an maintain the fully functional capacity of spermatogonia to produce sperm, but that host conditions

270 ntal to spermatogonial fate: the capacity of spermatogonia to respond to RA.

271 DMRT1 acts in spermatogonia to restrict RA responsiveness, directly re

272 nd genetic events in germ cells ranging from spermatogonia to spermatozoa.

273 translational repressor Bgcn is required for spermatogonia to stop mitosis and transition to meiotic

274 itiation factor STRA8, and causing most late spermatogonia to undergo apoptosis.

275 caused prolonged proliferation of progenitor spermatogonia, transiently enlarging this population.

276 l development is crucial for the gonocyte-to-spermatogonia transition and long-term spermatogenic hom

277 During spermatogenesis, spermatogonia undergo a series of mitotic and meiotic di

278 This was not the case for spermatogonia undergoing mitotic divisions.

279 effectively stimulated formation of aligned spermatogonia up to the 32-cell stage.

280 that promote maintenance of undifferentiated spermatogonia upregulate miR-221/222 expression; whereas

281 ls as a basis for purifying undifferentiated spermatogonia using fluorescence-activated cell sorting.

282 fication of human primitive undifferentiated spermatogonia (uSPG) highly enriched for SSCs.

283 post-stem-cell stages overall and stem-cell spermatogonia was smaller than is generally found with c

284 RNAs in primary cultures of undifferentiated spermatogonia were captured with oligo (dT)-conjugated b

285 ine transmission was not successful when the spermatogonia were cultured 6 weeks in the absence of do

286 as 10 d after birth, whereas differentiating spermatogonia were depleted.

287 togonial stem cell (SSC) pool nor progenitor spermatogonia were ever formed in the knockout testes.

288 hitecture of UBR2(-/-) testes was normal and spermatogonia were intact as well, but UBR2(-/-) spermat

289 Rb-deficient GFRa1(+) A(s) spermatogonia were present at normal density in testes 5

290 Finally, PAX7+ spermatogonia were present in the testes of a diverse se

291 usulfan selectively destroys differentiating spermatogonia whereas some of the spermatocytes present

292 those with the highest sensitivity being the spermatogonia, which form part of the basal cell layer,

293 fferentiation process, starting with diploid spermatogonia, which include germ-line stem cells, and e

294 matogonial population except in the GFRA1(+) spermatogonia, which includes spermatogonial stem cells

295 Spermatogonia, which produce sperm throughout the male l

296 Gli expression was somewhat higher in type B spermatogonia while the abundance of Gli3 transcripts wa

297 cking Zfp145 underwent a progressive loss of spermatogonia with age, associated with increases in apo

298 ically marks mouse gonocytes and a subset of spermatogonia with stem cell potential.

299 We show that all spermatogonia within a cyst die synchronously even when

300 acking Jak-STAT signaling differentiate into spermatogonia without self-renewal.