ライフサイエンスコーパス: spermatogonial

1 identify neuregulin as a factor required for spermatogonial amplification and differentiation in cult

2 n of germ cells into the pachytene stage, as spermatogonial and Sertoli cells were unaffected in knoc

3 eased transposon expression, and compromised spermatogonial and spermatocyte development during the f

4 ay, and we now show that irradiation-induced spermatogonial apoptosis is also p53-dependent.

5 XSxr(b)O males have spermatogonial arrest that can be overcome by the re-add

6 cultures on MSC-1 feeder layers resulted in spermatogonial behavior similar to that seen on feeder l

7 rnal age effect lies in the dysregulation of spermatogonial cell behavior, an effect mediated molecul

8 ntation experiments revealed that 6 week-old spermatogonial cell cultures maintained in the presence

9 Zebrafish spermatogonial cell cultures were established from Tg(pi

10 y PM cells is essential for undifferentiated spermatogonial cell development in vivo.

11 the basic signaling pathways that determine spermatogonial cell fate.

12 ion of some markers of stem cell and primary spermatogonial cell fate.

13 induced deposition of calcium phosphate in a spermatogonial cell line and this effect was fully rescu

14 The immortalized spermatogonial cell line may serve as a powerful tool in

15 ecause of accumulating replication errors in spermatogonial cell lines.

16 Using a panel of spermatogonial cell marker genes, we demonstrate that So

17 I3-K/AKT/p70S6K/cyclin D3 pathway to promote spermatogonial cell proliferation.

18 anding of the genetic networks that regulate spermatogonial cell renewal and differentiation, and wil

19 In mammals, spermatogonial cells (SPGs) are undifferentiated male ge

20 Lar is expressed in GSCs and early spermatogonial cells and localizes to the hub-GSC interf

21 N-ethyl N-nitrosourea to induce mutations in spermatogonial cells at an average specific locus rate o

22 ds from telomerase-immortalized mouse type A spermatogonial cells in the presence of stem cell factor

23 use they confer a selective advantage to the spermatogonial cells in which they arise.

24 ion, overexpression of miR-275 or miR-306 in spermatogonial cells resulted in a delay of the prolifer

25 vity specific for the Gli target sequence in spermatogonial cells.

26 F-like molecules stimulated the formation of spermatogonial chain length differently, we purified com

27 are required for effective formation of long spermatogonial chains.

28 M+/HLA-ABC-/CD49e- fraction was enriched for spermatogonial colonizing activity and did not form tumo

29 elf-renewal of SSCs in heterogeneous Thy1(+) spermatogonial cultures over a 63-day period without aff

30 racyst communication, compromise synchronous spermatogonial death and reduces overall germ cell death

31 The recessive juvenile spermatogonial depletion (jsd) mutation results in a sin

32 its sequence results in the sterile juvenile spermatogonial depletion (jsd) phenotype.

33 We identified the gene carrying the juvenile spermatogonial depletion mutation (jsd), a recessive spe

34 rm culture to give rise to multipotent adult spermatogonial-derived stem cells (MASCs).

35 s spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs).

36 By coordinating spermatogonial development and mitotic amplification wit

37 SOHLH proteins affect spermatogonial development by directly regulating Gfra1,

38 duction of GDNF by PM cells is essential for spermatogonial development by generating mice with a cKO

39 oduction of GDNF by PM cells is required for spermatogonial development, but PM cells might produce o

40 h1, thereby preventing meiosis and promoting spermatogonial development.

41 PLZF is also essential in osteoblast and spermatogonial development.

42 anslational repression of genes that promote spermatogonial differentiation and (2) repression of the

43 that by promoting OXPHOS, mitofusins enable spermatogonial differentiation and a metabolic shift dur

44 ggest that DMRT6 represses genes involved in spermatogonial differentiation and activates genes requi

45 d, most Dmrt6 mutant germ cells can complete spermatogonial differentiation and enter meiosis, but th

46 Retinoic acid (RA) is a requisite driver of spermatogonial differentiation and entry into meiosis, y

47 coordinating gene expression programs during spermatogonial differentiation and meiosis, which are es

48 Two premeiotic transitions, spermatogonial differentiation and meiotic initiation, w

49 two distinct, cell-type-specific responses: spermatogonial differentiation and meiotic initiation.

50 the transition in gametogenic programs from spermatogonial differentiation and mitosis to spermatocy

51 ansition in spermatogenesis is the exit from spermatogonial differentiation and mitotic proliferation

52 ult males induced, independently, precocious spermatogonial differentiation and precocious meiotic in

53 ration, antimicrobial peptide secretion, and spermatogonial differentiation are further highlighted t

54 A-deficient (VAD) mice; (2) the blockage of spermatogonial differentiation by impaired retinoid sign

55 We explored the mechanisms underlying spermatogonial differentiation by targeting expression o

56 scription, and activate transcription of the spermatogonial differentiation factor Sohlh1, thereby pr

57 tiation, causing inappropriate expression of spermatogonial differentiation factors, including SOHLH1

58 d signaling in germ cells completely blocked spermatogonial differentiation identical to vitamin A-de

59 ter, and Nr4a1 expression is diminished upon spermatogonial differentiation in vitro.

60 ate that the action of retinoid signaling on spermatogonial differentiation in vivo is direct through

61 s of Sohlh1 causes infertility by disrupting spermatogonial differentiation into spermatocytes.

62 Indeed, spermatogonial differentiation is accompanied by a globa

63 expression of Hes5, with a reduction of the spermatogonial differentiation marker, Neurog3 expressio

64 whether male germ cells undergo mitosis and spermatogonial differentiation or meiosis.

65 d, the competencies of germ cells to undergo spermatogonial differentiation or meiotic initiation in

66 phase; and (3) retinoid signaling regulated spermatogonial differentiation through controlling expre

67 6J strain, a null mutation in Dmrt6 disrupts spermatogonial differentiation, causing inappropriate ex

68 eas exposure to retinoic acid, an inducer of spermatogonial differentiation, downregulates miR-221/22

69 of transcripts encoding factors involved in spermatogonial differentiation, including those in the g

70 discovered that, although RA is required for spermatogonial differentiation, it is dispensable for th

71 transitions occurring in physical proximity: spermatogonial differentiation, meiotic initiation, init

72 ls in juvenile mice results in a blockage of spermatogonial differentiation, similar to that seen in

73 turbing spermatogenesis in vivo, focusing on spermatogonial differentiation, which begins a series of

74 Retinoic acid (RA) signaling is crucial for spermatogonial differentiation, which is a key step for

75 maintenance, and induce genes important for spermatogonial differentiation.

76 scriptional regulators that are essential in spermatogonial differentiation.

77 H transcription factor that is essential for spermatogonial differentiation.

78 Little is known about factors necessary for spermatogonial differentiation.

79 oop-helix transcription factor implicated in spermatogonial differentiation.

80 lele (Cdk2(Y15S) ) are severely deficient in spermatogonial differentiation.

81 l H3K27me3 deposition, leading to precocious spermatogonial differentiation.

82 ependent repression of over 750 genes during spermatogonial differentiation.

83 ge response pathway in the earliest steps of spermatogonial differentiation.

84 promotes (but is not strictly required for) spermatogonial differentiation.

85 IT, a receptor tyrosine kinase essential for spermatogonial differentiation.

86 ormation but rather are required for primary spermatogonial divisions in adult males.

87 germ cells lose pluripotency and commit to a spermatogonial fate.

88 nisms regulating a key switch fundamental to spermatogonial fate: the capacity of spermatogonia to re

89 del by which mammalian prospermatogonial and spermatogonial fates are regulated by their intrinsic ca

90 analyses reveal that HDAC3 represses meiotic/spermatogonial genes and activates postmeiotic haploid g

91 In agreement with Rice's hypothesis, spermatogonial genes are over-represented on the X chrom

92 Spermatogonial germ cells are still present but are unab

93 Most vertebrate spermatogonial GSCs appear to adopt an intermediate stra

94 associated DIS3 ribonuclease in maintaining spermatogonial homeostasis and facilitating germ cell di

95 test this hypothesis critically, we examined spermatogonial kinetics and numbers in rats in which the

96 echanism of protection involved an arrest of spermatogonial kinetics.

97 Spermatogenesis was blocked on the spermatogonial level by SRL treatment.

98 e characterise an essential role for DDX5 in spermatogonial maintenance and show that Ddx5 is indispe

99 tubules exhibiting altered expression of the spermatogonial markers MAGEA4, FGFR3, and phospho-AKT, w

100 s dazl, dnd, nanos3, vasa and piwil1 and the spermatogonial markers plzf and sox17 for at least six w

101 atogenesis can be divided into three stages: spermatogonial mitosis, meiosis of spermatocytes, and sp

102 germ cells inhibits the transition from the spermatogonial mitotic amplification program to spermato

103 esults support proposed selfish selection of spermatogonial mutations affecting growth factor recepto

104 ubset of induced cells properly colonize the spermatogonial niche.

105 Thus, changes in spermatogonial numbers or suppression of their prolifera

106 d at active promoters of genes essential for spermatogonial pluripotency and meiosis.

107 s a critical rheostat for maintenance of the spermatogonial pool and propose a model whereby negative

108 progenitor fraction of the undifferentiated spermatogonial pool.

109 ine led to reduction of the undifferentiated spermatogonial population and a block in transition to t

110 ess that is supported by an undifferentiated spermatogonial population and transition to a differenti

111 HLH2 proteins are co-expressed in the entire spermatogonial population except in the GFRA1(+) spermat

112 ing approximately 2% of the undifferentiated spermatogonial population in adulthood.

113 relies on the actions of an undifferentiated spermatogonial population that is composed of stem cells

114 s, which is supported by an undifferentiated spermatogonial population.

115 ex subunit CNOT3 is essential for sustaining spermatogonial populations in mice.

116 ogeneous epithelial-like or mesenchymal-like spermatogonial populations, with the latter displaying e

117 e examined mutations induced by treatment of spermatogonial (premeiotic) cells with the chemical muta

118 Using spermatogonial progenitor cells (SPCs) as a model system

119 ere, we show that highly proliferative adult spermatogonial progenitor cells (SPCs) can be efficientl

120 germ cells and differentiation of postnatal spermatogonial progenitor cells (SPCs).

121 ate approximately a quarter of newly emerged spermatogonial progenitors, a role seemingly contradicto

122 auses spermatogonia to precociously exit the spermatogonial program and enter meiosis.

123 the introduction of Eif2s3y restores normal spermatogonial proliferation and progression through mei

124 bution is limited to only two genes, Sry and spermatogonial proliferation factor Eif2s3y.

125 s, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.

126 ize is reduced in these mice due to aberrant spermatogonial proliferation.

127 a Y chromosomal factor essential for normal spermatogonial proliferation.

128 ignaling pathway, is associated with selfish spermatogonial selection and raises the possibility that

129 rocess akin to tumorigenesis, termed selfish spermatogonial selection.

130 roplasia), this process is known as "selfish spermatogonial selection." This mechanism favors propaga

131 Spermatogonial self-renewal and differentiation are esse

132 on of genes previously identified as SSC and spermatogonial-specific markers (e.g., zinc-finger and B

133 he system we measured repair outcomes at the spermatogonial, spermatocyte, and spermatid stages of sp

134 Y719F mutation blocks spermatogenesis at the spermatogonial stages and in contrast the KitY567F mutat

135 st-natal male germline cells identifies four spermatogonial states.

136 Spermatogonial stem and progenitor cells (SSCs) generate

137 om the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in its periphery

138 We evaluated spermatogonial stem cell (SSC) activity in the developin

139 importance of individual miRs in controlling spermatogonial stem cell (SSC) homeostasis has not been

140 malian spermatogenic lineage, a foundational spermatogonial stem cell (SSC) pool arises from prosperm

141 their lives depends upon establishment of a spermatogonial stem cell (SSC) pool from gonocyte progen

142 Consequently, neither the foundational spermatogonial stem cell (SSC) pool nor progenitor sperm

143 and pale (Ap) spermatogonia that make up the spermatogonial stem cell (SSC) pool.

144 enile quiescence of germ cells with immature spermatogonial stem cell (SSC) precursors (gonocytes) pr

145 Spermatogonial stem cell (SSC) self-renewal and differen

146 s suggest that exogenous factors crucial for spermatogonial stem cell (SSC) self-renewal are conserve

147 NADPH1 oxidase 1 (NOX1) are thought to drive spermatogonial stem cell (SSC) self-renewal through feed

148 DNF, an essential growth factor required for spermatogonial stem cell (SSC) self-renewal.

149 , a Bmp type I receptor inhibitor, prolonged spermatogonial stem cell (SSC) survival in culture and e

150 The spermatogonial stem cell (SSC) that supports spermatogen

151 The mechanisms that guide the continuum of spermatogonial stem cell (SSC) to progenitor spermatogon

152 Spermatogonial stem cell (SSC) transplantation has been

153 how that conditional deletion of Tert in the spermatogonial stem cell (SSC)-containing population in

154 In contrast, the recently developed spermatogonial stem cell assay system allows quantitatio

155 losely related species with similar rates of spermatogonial stem cell divisions but a shorter mean ag

156 The lifelong spermatogonial stem cell divisions unique to male germ c

157 ike primordial germ cells toward a unipotent spermatogonial stem cell fate.

158 We establish a spermatogonial stem cell index (SSCI) that reliably pred

159 The spermatogonial stem cell initiates and maintains spermat

160 of mouse spermatogonial stem cells, a mouse spermatogonial stem cell line and freshly isolated testi

161 and revealed a novel function in regulating spermatogonial stem cell maintenance.

162 erm cells and the identification of a set of spermatogonial stem cell marker transcripts.

163 adhesion receptor ADGRA3 (GPR125) is a known spermatogonial stem cell marker, but its impact on male

164 proliferation is impaired and expression of spermatogonial stem cell markers c-Ret, Plzf, and Stra8

165 manner, implying failure of maintaining the spermatogonial stem cell niche in somatic cells.

166 urotrophic factor (GDNF), a component of the spermatogonial stem cell niche produced by the somatic S

167 g a classic stem cell system, the Drosophila spermatogonial stem cell niche, we reveal daily rhythms

168 nd blood flow are known to contribute to the spermatogonial stem cell niche.

169 id not substantially impact the diversity of spermatogonial stem cell pools in these individuals.

170 The adult spermatogonial stem cell population arises from pluripot

171 The identity of the spermatogonial stem cell population in the undisturbed t

172 We report here that GDNF promotes spermatogonial stem cell proliferation through activatio

173 view the developments that have been made in spermatogonial stem cell research and potential future u

174 estigation of molecular mechanisms governing spermatogonial stem cell self renewal and hierarchical d

175 ruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in

176 toli cells in the testis and is required for spermatogonial stem cell self-renewal.

177 ole H3K79 methyltransferase, is required for spermatogonial stem cell self-renewal.

178 TAF4b may be required for the regulation of spermatogonial stem cell specification and proliferation

179 Despite the central importance of the spermatogonial stem cell to male reproduction, little is

180 Spermatogonial stem cell transplantation (SSCT) is an ex

181 Spermatogonial stem cell transplantation began as a theo

182 Restoration of fertility following spermatogonial stem cell transplantation in animals sugg

183 We demonstrate spermatogonial stem cell-associated antigens by using an

184 s their repressive state when present in the spermatogonial stem cell.

185 Human adult spermatogonial stem cells (hSSCs) must balance self-rene

186 In this study, spermatogonial stem cells (SSC) that harbor paternalized

187 selfish mutations: substitutions that grant spermatogonial stem cells (SSCs) a selective advantage i

188 Spermatogonial stem cells (SSCs) are a subpopulation of

189 Spermatogonial stem cells (SSCs) are at the foundation o

190 Male germline or spermatogonial stem cells (SSCs) are conserved across ma

191 Spermatogonial stem cells (SSCs) are essential for adult

192 Spermatogonial stem cells (SSCs) are essential for the g

193 Spermatogonial stem cells (SSCs) are generally character

194 Spermatogonial stem cells (SSCs) are responsible for mai

195 Spermatogonial stem cells (SSCs) are the basis of sperma

196 Spermatogonial stem cells (SSCs) are the foundation for

197 Spermatogonial stem cells (SSCs) are unipotent germ cell

198 Spermatogonial stem cells (SSCs) are unique among tissue

199 he untimely and excessive differentiation of spermatogonial stem cells (SSCs) by disturbing the expre

200 Spermatogonial stem cells (SSCs) capable of self-renewal

201 Spermatogonial stem cells (SSCs) form the basis of male

202 Spermatogonial stem cells (SSCs) have the dual capacity

203 ction of functional sperm from self-renewing spermatogonial stem cells (SSCs) in cell culture conditi

204 erm line stem cells (GSCs) in Drosophila, or spermatogonial stem cells (SSCs) in mammals.

205 Self-renewal and differentiation by spermatogonial stem cells (SSCs) is the foundation for c

206 Self-renewal of spermatogonial stem cells (SSCs) is the foundation for m

207 Spermatogonial stem cells (SSCs) maintain spermatogenesi

208 Spermatogonial stem cells (SSCs) maintain spermatogenesi

209 Postnatal spermatogonial stem cells (SSCs) progress through prolif

210 Self-renewal and differentiation of spermatogonial stem cells (SSCs) provide the foundation

211 Spermatogonial stem cells (SSCs) self-renew and produce

212 self-renewal and differentiation programs of spermatogonial stem cells (SSCs) that is regulated by re

213 permatogenesis is initiated and sustained by spermatogonial stem cells (SSCs) through self-renewal an

214 ent results have demonstrated the ability of spermatogonial stem cells (SSCs) to de-differentiate int

215 In spermatogonial stem cells (SSCs), Myc controls SSC fate

216 We observed a paucity of mutant spermatogonial stem cells (SSCs), which appears independ

217 eating transchromosomic mice by manipulating spermatogonial stem cells (SSCs), which exhibited superi

218 easonal spermatogenesis in fish is driven by spermatogonial stem cells (SSCs), which undergo a comple

219 n the GFRA1(+) spermatogonia, which includes spermatogonial stem cells (SSCs).

220 gametes originate from a small population of spermatogonial stem cells (SSCs).

221 epigenetic reprogramming, and spermatogonia/spermatogonial stem cells (SSCs).

222 enesis and lifelong fertility is provided by spermatogonial stem cells (SSCs).

223 level is essential for homeostasis in murine spermatogonial stem cells (SSCs).

224 population size and differentiation fate of spermatogonial stem cells (SSCs).

225 testis, sustained spermatogenesis relies on spermatogonial stem cells (SSCs); their progeny either r

226 Thus, to proliferate, spermatogonial stem cells activate mechanisms that are s

227 n provides insight into the amplification of spermatogonial stem cells and the origin of primordial f

228 are prospermatogonia), increases steadily as spermatogonial stem cells appear, plateaus as the first

229 Age-related changes in spermatogonial stem cells appeared modest, whereas age-r

230 This results, in part, from the fact that spermatogonial stem cells are an extremely rare cell pop

231 e generated a transgenic mouse line in which spermatogonial stem cells are marked by expression of an

232 Spermatogonial stem cells are required for the initiatio

233 Although spermatogonial stem cells are unipotent, these cells are

234 tal period in the non-dividing precursors of spermatogonial stem cells at a stage where retrotranspos

235 required for the survival of mouse PGCs and spermatogonial stem cells by suppressing apoptosis.

236 CBX2 is up-regulated as spermatogonial stem cells differentiate and is required

237 Spermatogenesis is the process by which spermatogonial stem cells divide and differentiate to pr

238 Spermatogonial stem cells divide throughout life, mainta

239 Thus, molecular markers specific for spermatogonial stem cells establish a reliable and rapid

240 Recently, transplantation of mouse donor spermatogonial stem cells from a fertile testis to an in

241 Thus, transplantation of spermatogonial stem cells from an infertile donor to a p

242 we examine the feasibility of transplanting spermatogonial stem cells from other species to the mous

243 highlights the in-vitro propagation of human spermatogonial stem cells from testicular biopsies for f

244 First, spermatogonial stem cells from the adult cryptorchid tes

245 Spermatogonial stem cells functionality reside in the sl

246 consistent with germline selection: mutated spermatogonial stem cells gained an advantage that allow

247 Whereas in-vitro propagation of spermatogonial stem cells has been established in animal

248 ve clonal fate studies of transplanted mouse spermatogonial stem cells in host seminiferous tubules.

249 antation experiments revealed a depletion of spermatogonial stem cells in the adult.

250 rmatogenesis involves the differentiation of spermatogonial stem cells into spermatocytes via mitotic

251 of the genome, and telomerase expression in spermatogonial stem cells is responsible for the mainten

252 Self-renewal of spermatogonial stem cells is vital to lifelong productio

253 vitro retroviral-mediated gene delivery into spermatogonial stem cells of both adult and immature mic

254 permatogenesis in mouse testes suggests that spermatogonial stem cells of many species could be trans

255 was not functionally redundant with NSun2 in spermatogonial stem cells or Sertoli cells.

256 Division of spermatogonial stem cells produces daughter cells that e

257 Although spermatogonial stem cells remain unaffected, proliferati

258 ave now devised culture conditions where rat spermatogonial stem cells renew and proliferate in cultu

259 Maintenance of spermatogonial stem cells requires the transcriptional r

260 Spermatogonial stem cells reside in specific niches with

261 ermore, the presence of surface integrins on spermatogonial stem cells suggests that these cells shar

262 ideal surrogate for transplantation of donor spermatogonial stem cells to expand the availability of

263 after treatment, suggesting that persistent spermatogonial stem cells were not sensitive to NOVP.

264 ence of Pramef12 expression, there are fewer spermatogonial stem cells which exhibit lower expression

265 Transfection of the spermatogonial stem cells with a plasmid containing the

266 ance and differentiation of gonocytes and/or spermatogonial stem cells would be modulated through thi

267 l systems, we used primary cultures of mouse spermatogonial stem cells, a mouse spermatogonial stem c

268 arch surrounds the regenerative potential of spermatogonial stem cells, a recent article highlights t

269 ovessels may contribute to the regulation of spermatogonial stem cells, as well.

270 Mice lacking DOT1L fail to maintain spermatogonial stem cells, characterized by a sequential

271 In contrast to spermatogonial stem cells, gonocytes can be identified e

272 Given STAT3's function in mouse spermatogonial stem cells, we suggest that this interact

273 al germ cells in the embryo and give rise to spermatogonial stem cells, which establish and maintain

274 e cyst cells break apart and probably become spermatogonial stem cells.

275 nuclear factor-Y is required for maintaining spermatogonial stem cells.

276 is: regulation of meiosis and maintenance of spermatogonial stem cells.

277 pment, hematopoiesis, and differentiation of spermatogonial stem cells.

278 ach for purification and characterization of spermatogonial stem cells.

279 rat model made by germline gene targeting in spermatogonial stem cells.

280 on, and resulted in a 166-fold enrichment of spermatogonial stem cells.

281 tial for reproduction, little is known about spermatogonial stem cells.

282 te-determining HoxC transcription factors in spermatogonial stem cells.

283 ide an epigenetic paradigm for regulation of spermatogonial stem cells.

284 es impaired differentiation of embryonic and spermatogonial stem cells.

285 fetal testes, resulting in the formation of spermatogonial stem cells: the foundational stem cells r

286 sequent extensive apoptosis occurring at the spermatogonial stem-cell level.

287 sexes, with males also exhibiting defective spermatogonial stem-cell renewal.

288 essed in other locations, notably within the spermatogonial stem/progenitor cell population in postna

289 SOX3 functions as a pro-commitment factor in spermatogonial stem/progenitor cells.

290 ll-autonomously in somatic cells to maintain spermatogonial stemness.

291 mbrane attachment reverting mesenchymal-like spermatogonial subtype cells back to an epithelial-like

292 ein is required for male germ cells to cease spermatogonial TA divisions and initiate spermatocyte di

293 spermatogonial stem cell (SSC) to progenitor spermatogonial transition and precise identifiers of sub

294 occur in prospermatogonia prior to postnatal spermatogonial transition, the importance of this has no

295 f stem cells with basement membranes and our spermatogonial transplantation assay system to identify

296 Spermatogonial transplantation experiments revealed a de

297 In this study, we used the spermatogonial transplantation functional assay, combine

298 We used the technique of spermatogonial transplantation in two infertile mouse st

299 Although the development of the spermatogonial transplantation technique has provided an

300 demonstrate, by using the recently developed spermatogonial transplantation technique, that male germ