ライフサイエンスコーパス: spermidine

1 rates, such as polyamines (e.g. spermine and spermidine).

2 yamines and in particular polyamines such as spermidine.

3 most normally with homospermidine instead of spermidine.

4 ccharide and protein, requires the polyamine spermidine.

5 utophagy dependent manner using the compound spermidine.

6 condensation induced by the trivalent cation spermidine.

7 key step in the production of the polyamine spermidine.

8 e tested for Hst 5 sensitivity and uptake of spermidine.

9 administration of rapamycin, resveratrol, or spermidine.

10 CANSDH led to loss of sym-norspermidine and spermidine.

11 ogenously supplied sym-norspermidine but not spermidine.

12 o assess DNA condensation with the polyamine spermidine.

13 n which was not compensated by intracellular spermidine.

14 esis is from ornithine through putrescine to spermidine.

15 (EC50 = 1.4 muM) in inhibiting the uptake of spermidine (1 muM) in DFMO-treated L3.6pl human pancreat

16 (0.2-1.7), N(1),N(10)-bis-(dihydrocaffeoyl) spermidine (1.1-2.6), and N(1),N(5),N(14)-tris-(dihydroc

17 sults presented here, high concentrations of spermidine(3+) did not produce the premature stalling ob

18 The only exception to these behaviors is spermidine(3+), whose weaker influence on the docking eq

19 K(+), Mg(2+), Ca(2+), Co(NH(3))(6)(3+), and spermidine(3+).

20 re permeable not only to NMDG(+) but also to spermidine, a large natural cation involved in ion chann

21 ed disruption of SMS in CRC cells results in spermidine accumulation, which inhibits FOXO3a acetylati

22 digestion, whereas tyramine, cadaverine and spermidine after digestion.

23 in the presence of integration host factor, spermidine also increased insertion at the CRISPR locus

24 ine, and N(1),N(5),N(10)-tri-p-(E)-coumaroyl spermidine amides.

25 oside and N(1),N(5),N(10)-triphenylpropenoyl spermidine amides.

26 ylcholine, diacylglycerol, monoacylglycerol, spermidine, amyloid-beta, amylin, and osmotic shock.

27 Spermidine, an endogenous polyamine metabolite, induces

28 Biosynthesis of spermidine analogue aminopropylcadaverine, but not exoge

29 Intracellular biosynthesis of another spermidine analogue, aminopropylcadaverine, from exogeno

30 The differential ability of C-methylated spermidine analogues to functionally replace spermidine

31 ation of spermine and N(1)-acetylspermine to spermidine and 3-aminopropanal or N-acetyl-3-aminopropan

32 (SMO) catalyzes the oxidation of spermine to spermidine and 3-aminopropanal.

33 T upon host-cell contact, but do not produce spermidine and are phagocytosed less.

34 polyamine oxidase specific for spermine and spermidine and diamine oxidase specific for putrescine,

35 SMO) metabolizes the polyamine spermine into spermidine and generates H(2)O(2), which causes apoptosi

36 Multivalent cations such as spermidine and magnesium induce attraction between packa

37 lysosomal transmembrane protein, as well as spermidine and N-acetylglucosamine biosynthesis, all con

38 ed higher sensitivity (from 0.02mgkg(-1) for spermidine and phenylethylamine to 0.2mgkg(-1) for sperm

39 e amidino acceptor substrate, especially for spermidine and putrescine (Km values of 33 mum and 3.9 m

40 an exogenous application of two polyamines, Spermidine and Putrescine (SPD-PUT), was tested in multi

41 These findings suggest that spermidine and putrescine levels could be useful markers

42 The up-regulation of polyamines (spermidine and putrescine) and potassium may mitigate ox

43 regulated, and the levels of the polyamines, spermidine and putrescine, were found to be increased wh

44 With the exception of spermidine and spermine a wide variation of BA levels wa

45 Cationic polyamines such as spermidine and spermine are critical in all forms of lif

46 Polyamines such as spermidine and spermine are primordial polycations that

47 ism critically involved in the conversion of spermidine and spermine back to putrescine.

48 ates synthesis of the polyamines putrescine, spermidine and spermine by controlling stability of the

49 Polyamines spermidine and spermine did not show statistically signi

50 The polyamines spermidine and spermine did not show statistically signi

51 The content of spermidine and spermine in mammalian cells has important

52 Spermidine and spermine originate mainly from raw materi

53 Dietary polyamines spermidine and spermine participate in an array of physi

54 T1), which catalyzes the N(1)-acetylation of spermidine and spermine to form acetyl derivatives, is a

55 Putrescine, spermidine and spermine were measured as dansylated deri

56 rescine, and cadaverine) and two polyamines (spermidine and spermine) in 112 samples of dairy product

57 tryptamine and tyramine) and two polyamines (spermidine and spermine) were detected in cocoa beans du

58 cadaverine, histamine, serotonine, tyramine, spermidine and spermine), as well as microbiological pro

59 T1 effect is most likely due to depletion of spermidine and spermine, because stable polyamine analog

60 idence for a primary function of polyamines, spermidine and spermine, in translation in mammalian cel

61 ent of polyamines (75-124 and 11-24 mg/kg of spermidine and spermine, respectively).

62 denovirus led to rapid depletion of cellular spermidine and spermine, total inhibition of protein syn

63 Spermidine and spermine, which enhance duplex stability,

64 G from V. cholerae showed that it acetylates spermidine and spermine.

65 from acetyl coenzyme A to polyamines such as spermidine and spermine.

66 brellas, derived from cholic acid, L-lysine, spermidine, and Cascade Blue, to cross fluid liposomal m

67 tions, TryS displays Km values for GSH, ATP, spermidine, and Gsp of 34, 18, 687, and 32 mum, respecti

68 0)-(E)-caffeoyl-N(1),N(5)-di-p-(E)-coumaroyl spermidine, and N(1),N(5),N(10)-tri-p-(E)-coumaroyl sper

69 bolites, including histidine, phenylalanine, spermidine, and phosphatidylcholine C34:4, has a diagnos

70 Putrescine, spermidine, and spermine (i.e., polyamines) are small ca

71 The polyamines putrescine, spermidine, and spermine are required for normal eukaryo

72 Putrescine, spermidine, and spermine are the polyamines required for

73 reduced levels of the polyamines putrescine, spermidine, and spermine in mutant inflorescences.

74 with intracellular depletion of putrescine, spermidine, and spermine resulting in cellular growth ar

75 s, tyramine, histamine, dopamine, serotonin, spermidine, and spermine were decreased during the ripen

76 The polyamines, putrescine, spermidine, and spermine, are essential polycations, int

77 Polyamines, such as putrescine, spermidine, and spermine, are physiologically important

78 racellular depletion of methionine, leucine, spermidine, and spermine, but not putrescine.

79 onine leads to an inability to biosynthesize spermidine, and spermine.

80 ylarginine/arginine ratio, butyrylcarnitine, spermidine, and the total amount of essential amino acid

81 The polyamines putrescine, spermine, and spermidine are abundant within the gastrointestinal trac

82 Both HDAC10 and spermidine are known to promote cellular survival throug

83 The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimola

84 aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic (tyramine, phenylethylamine) or he

85 We aimed to characterize the polyamine spermidine as a modulator of T-cell differentiation and

86 These data implicate spermidine as a potential therapeutic agent to treat con

87 sma, levels of the polyamines putrescine and spermidine as well as the collagen breakdown product pro

88 In humans, high levels of dietary spermidine, as assessed from food questionnaires, correl

89 To test this concept, a budding yeast spermidine auxotrophic strain was found to grow almost n

90 The ABHD5/SRM/spermidine axis in TAMs might represent a potential targ

91 case of trypanothione disulfide (TS2), a GSH-spermidine bioconjugate, involved in the antioxidative s

92 on, similar to young donors' cells, in which spermidine biosynthesis has been inhibited.

93 aramecium lost the eukaryotic genes encoding spermidine biosynthesis: S-adenosylmethionine decarboxyl

94 iasis, inhibits the first step in polyamine (spermidine) biosynthesis, a highly regulated pathway in

95 showed that activity of a key trypanosomatid spermidine biosynthetic enzyme, S-adenosylmethionine dec

96 lar metazoan Schistosoma worms have lost the spermidine biosynthetic pathway but retain deoxyhypusine

97 Treatment with putrescine or spermidine blocks myelin-mediated inhibition of neurite

98 ), acetylates polyamines such as putrescine, spermidine, cadaverine, and homospermidine present in bo

99 of aging, and nutritional supplementation of spermidine can reduce age-related pathology and increase

100 Finally, rapamycin as well as spermidine, carbamazepine, and tamoxifen could also resc

101 (mTOR) and three other autophagy activators (spermidine, carbamazepine, and tamoxifen) in a FTLD-U mo

102 Typhimurium revealed novel latent spermidine catabolic activity producing non-native 1,3-d

103 SMS deficiency leads to excessive spermidine catabolism, which generates toxic metabolites

104 ydrodynamic mobility to evaluate the size of spermidine-condensed DNA and single molecule burst analy

105 er gene (acyltransferase DH29), specific for spermidine conjugation, mediates the initial acylation s

106 d SPDS2 mRNA abundance, significantly higher spermidine content, and increased polyamine oxidase (PAO

107 he enzymatic product of spermidine synthase, spermidine, cycles as well.

108 We report here that in a spermidine-deficient B. subtilis mutant, the structural

109 of sinR or ectopic expression of slrR in the spermidine-deficient DeltaspeD background restored biofi

110 eoxyhypusine synthase, which is required for spermidine-dependent hypusine modification of a lysine r

111 ent are thermospermine synthase activity and spermidine-dependent posttranslational modification of e

112 Transcriptomic analysis of a spermidine-depleted B. subtilis speD mutant uncovered a

113 Development in spermidine-depleted gametophytes was arrested before the

114 In spermidine-depleted spermatogenous cells, chromatin fail

115 d increased 8-fold with norC overexpression, spermidine did not induce expression of norC and other p

116 ecifically, the polyamines norspermidine and spermidine enhance and repress V. cholerae biofilm forma

117 Spermine, but not spermidine, enhanced NMDA-induced depolarization of moto

118 tions showed greater levels of spermine than spermidine, except for the 5th day post-partum.

119 ral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardi

120 the endogenous autophagy-inducing metabolite spermidine fall in human T cells with age.

121 Spermidine feeding enhanced cardiac autophagy, mitophagy

122 Spermidine feeding failed to provide cardioprotection in

123 pertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, incr

124 CpaN molecules cross-linked by the polyamine spermidine following reaction with the thioester bonds.

125 ain was auxotrophic for polyamines, required spermidine for growth in its insect vector form, and was

126 ulate homospermidine, suggesting it replaces spermidine for growth.

127 s largely mediated through a requirement for spermidine for the downstream posttranslational modifica

128 showed that Hst 5 is a competitive analog of spermidine for uptake into C. albicans cells, and that H

129 the novel de novo synthesis of the triamine spermidine from the diamine putrescine by fusion enzymes

130 ilm regulator slrR Our results indicate that spermidine functions in biofilm development by activatin

131 arily optimized with respect to the reaction spermidine --> spermine.

132 0.001); (3) polyamine synthesis/catabolism (spermidine: higher in AD, p = 0.004); (4) urea cycle (N-

133 -inducing CRMs, including hydroxycitrate and spermidine, improved the inhibition of tumor growth by c

134 spermidine analogues to functionally replace spermidine in biofilm formation indicated that the amino

135 fluorescence turn-on assays of spermine and spermidine in biological samples.

136 d for their ability to inhibit the import of spermidine in DFMO-treated Chinese hamster ovary (CHO) a

137 presence of extracellular concentrations of spermidine in growing cultures of R. sphaeroides gave ri

138 of prostatic cancer biomarkers spermine and spermidine in real clinical applications with reduced sa

139 e precursors, supplementation of spermine or spermidine in the borrelial growth medium induced synthe

140 and drug treatments were employed to deplete spermidine in the gametophyte at different stages of gam

141 Hydric stress caused accumulation of spermidine in the grains and affected the levels of othe

142 hat the effect of multivalent cations and of spermidine, in particular, on the dynamics of DNA packin

143 ment of T84 and HT29/cl.19A colonocytes with spermidine increased both TCPTP protein levels and enzym

144 S) is an enzyme which function is to convert spermidine into spermine.

145 s observed in the systems with magnesium and spermidine ions compared to the system with only salt.

146 s study demonstrated that the small molecule spermidine is a selective activator of TCPTP in vitro.

147 The polyamine spermidine is absolutely required for growth and cell pr

148 Spermidine is depleted in the elderly, leading to reduce

149 Spermidine is essential for viability and acts as the pr

150 ion indicated that the aminopropyl moiety of spermidine is more sensitive to C-methylation, which it

151 Ubiquitous polyamine spermidine is not required for normal planktonic growth

152 restored biofilm formation, indicating that spermidine is required for expression of the biofilm reg

153 is essential in T. brucei, and the polyamine spermidine is required for synthesis of a novel cofactor

154 are mixed, AdoMetDC activity is restored and spermidine is synthesized.

155 ey step in the biosynthesis of the polyamine spermidine, is activated by dimerization with an inducib

156 key enzyme for biosynthesis of the polyamine spermidine, is activated by heterodimer formation with a

157 mic acids and two polyamines, putrescine and spermidine, is regulated by this transcription factor.

158 c analysis also showed that hydroxycinnamoyl spermidines, known components of the pollen coat, were e

159 ce exhibit significant reductions of gastric spermidine levels and H. pylori-induced inflammation.

160 s and total polyamines; and iii) the highest spermidine levels and total acidity, but the lowest tota

161 vealed that Me(2)SPM significantly decreases spermidine levels in multiple tissues.

162 Spermidine levels rise first in sterile jacket cells and

163 (2)SPM, resulting in significantly decreased spermidine levels with no adverse effects on growth.

164 In untreated gametophytes, spermidine made in the jacket cells moves into the sperm

165 Finally, our data show that endogenous spermidine maintains autophagy via the translation facto

166 Spermidine modulates CD4(+) T-cell differentiation in vi

167 The spermidine N-acetyltransferase SpeG is a dodecameric enz

168 Spermidine N-acetyltransferase, encoded by the gene speG

169 ),N(10)-di-(E)-caffeoyl-N(5)-p-(E)-coumaroyl spermidine, N(1)-(E)-caffeoyl-N(5),N(10)-di-p-(E)-coumar

170 )-(E)-caffeoyl-N(5),N(10)-di-p-(E)-coumaroyl spermidine, N(10)-(E)-caffeoyl-N(1),N(5)-di-p-(E)-coumar

171 rapamycin, senolytics, metformin, acarbose, spermidine, NAD(+) enhancers and lithium.

172 The effect of spermidine on the levels of select borrelial proteins wa

173 This results in the expression of spermidine on the surface, which specifically activates

174 Other autophagy-inducing drugs, such as spermidine or add-on therapy with widely used antiathero

175 ow that addition of the ubiquitous polyamine spermidine or of another polyamine, spermine, significan

176 We found that treating spores directly with spermidine or other polyamines was sufficient to unmask

177 nized both putrescine and cadaverine but not spermidine or spermine.

178 ce were subjected to oral supplementation of spermidine, or its precursor l-arginine, to assess the f

179 results highlight the beneficial effects of spermidine, or l-arginine, on gut immunity by promoting

180 Here, we show that the polyamine spermidine plays a key role as a morphogenetic determina

181 hich metabolizes the polyamine spermine into spermidine plus H(2)O(2), is associated with increased h

182 mine (Me(2)SPM), to reduce the intracellular spermidine pools of SRS patient-derived cells.

183 the cell and, in response, decreasing excess spermidine pools to normal levels.

184 lvage ornithine and have some access to host spermidine pools, while host putrescine appears to be un

185 Mechanistically, spermidine post-translationally modifies the translation

186 perlipidemic mice via oral administration of spermidine prevented the increase in aortic IL-6 and Par

187 ppresses spermidine synthase (SRM)-dependent spermidine production in macrophages by inhibiting the r

188 olytic factor ABHD5 suppresses SRM-dependent spermidine production in TAMs and potentiates the growth

189 Furthermore, dietary supplementation with spermidine promotes homeostatic differentiation of Treg

190 to the conclusion that addition of exogenous spermidine promotes longevity through autophagy inductio

191 On a functional level, spermidine protected barrier function in the setting of

192 Three metabolites (spermidine, putrescine and glutamine) significantly diff

193 uding reduced levels of dephosphocoenzyme A, spermidine, putrescine, and phosphatidylethanolamines an

194 Eight biogenic amines (spermine, spermidine, putrescine, histamine, tyramine, phenylethyl

195 biomarker performance of the two polyamines (spermidine/putrescine) was enhanced by ratio with CSF Ab

196 Notably, addition of 2 mm spermidine quenched the off-target spacer insertion rate

197 The spermine/spermidine ratio in lymphoblasts was 0.53, significantly

198 thase show clearly that the correct spermine:spermidine ratio is critical for normal growth and devel

199 cells were determined, and it was found that spermidine remained unchanged and putrescine increased b

200 However, the structural features of spermidine required for B. subtilis biofilm formation ar

201 However, the levels of spermidine required to inhibit biofilm formation through

202 Consistent with the spermidine requirement in biofilm formation, single-cell

203 t supplementation with as little as 10(-8) m spermidine restores their growth.

204 ferirel (relBbu ; bb0198) in the presence of spermidine revealed the interplay of multiple regulatory

205 These results indicate that spermidine's polarizing effect requires an intact autoph

206 Putrescine and spermine, but not spermidine, showed evidence of co-operative stimulation

207 d by ratio with CSF Abeta42 (ROC > 0.8), and spermidine significantly correlated with Abeta42 (pearso

208 ying of grapevines with putrescine (Put) and spermidine (Spd) (0, 1, 2mM) was evaluated for determini

209 ompared the effects of trivalent polyamines, spermidine (SPD) and norspermidine (NSPD), a chemical ho

210 portant biogenic polyamines; spermine (SPM), spermidine (SPD) and putrescine (PUT), or electrochemica

211 Diamine putrescine (Put) and polyamines; spermidine (Spd) and spermine (Spm) are essential compon

212 ved three biogenic amines: putrescine (Put), spermidine (Spd) and spermine (Spm), and their derivativ

213 solation and identification of the polyamine spermidine (SPD) as another significant immunomodulatory

214 catalyse the conversion of spermine (Spm) to spermidine (Spd) in vitro.

215 transgenic lines accumulate higher levels of spermidine (Spd) than the wild-type plants and were exam

216 Spermidine (SPD), a naturally occurring polyamine, has b

217 Polyamines, including spermine (Spm) and spermidine (Spd), are aliphatic cations that are reporte

218 AP), putrescine (Put), cadaverine (Cad), and spermidine (Spd), as carbon and/or nitrogen sources.

219 PA model compound, i.e. putrescine (PUT) or spermidine (SPD), or with no addition as controls (CTRs)

220 esence of the triply positively charged base spermidine (Spd).

221 rabidopsis thaliana an early drought-induced spermidine spermine-N(1) -acetyltransferase homolog, whi

222 y S. aureus USA300 and E. faecalis acetylate spermidine, spermine and norspermidine, that spermine is

223 adaverine, tryptamine, beta-phenylethylamine spermidine, spermine were analysed by UV detection after

224 eractions of natural polyamines (putrescine, spermidine, spermine) and polyamine-like potent OCT1 blo

225 nalyzed rectal mucosal levels of polyamines (spermidine, spermine, and putrescine) and PGE2, treatmen

226 ven biogenic amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine and tryptamine

227 ght biogenic amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine, tryptamine an

228 f the following: (i) addition of putrescine, spermidine, spermine, or N(1)-AcSpd did not restore the

229 The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an e

230 ng enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encode

231 Spermidine/spermine acetyltransferase (SAT1) is the rate

232 d by an upregulation of the degrading enzyme spermidine/spermine acetyltransferase.

233 diethylnorspermine (DENSpm), an activator of spermidine/spermine N(1)-acetyltransferase (SAT1).

234 m resulted in a rapid induction of host cell spermidine/spermine N(1)-acetyltransferase 1 (hSSAT-1) m

235 by overexpression of a key catabolic enzyme, spermidine/spermine N(1)-acetyltransferase 1 (SAT1) in m

236 Spermidine/spermine N(1)-acetyltransferase 1 (SSAT1), wh

237 Here, we identified the SAT1 (spermidine/spermine N(1)-acetyltransferase 1) gene as a

238 Spermidine/spermine N(1)-acetyltransferase 2 (SSAT2) or

239 Moreover, P-S induces spermidine/spermine N(1)-acetyltransferase enzymatic act

240 We show that spermidine/spermine N-acetyltransferase (SSAT) homologue

241 Enhanced flux is driven by spermidine/spermine N1-acetyltransferase (SSAT) activity

242 ogen induces the first and regulatory enzyme spermidine/spermine N1-acetyltransferase (SSAT) in a pol

243 localizes the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close

244 Spermidine/spermine N1-acetyltransferase 1 (SAT1), the r

245 expression of the catabolic polyamine enzyme spermidine/spermine N1-acetyltransferase 1 (SAT1).

246 urth, we show that the blood levels of SAT1 (spermidine/spermine N1-acetyltransferase 1), the top bio

247 synthesis of the polyamine catabolic enzyme spermidine/spermine-N(1)-acetyltransferase (SSAT) in res

248 was a poor substrate of spermine oxidase and spermidine/spermine-N(1)-acetyltransferase (SSAT) when c

249 concentrations, the polyamines spermine and spermidine stimulate codon recognition by the ribosome w

250 known and so are the molecular mechanisms of spermidine-stimulated biofilm development.

251 observation made in our in vitro system that spermidine strongly decreases nonspecific activity of Ca

252 ell as the internal and distal amines in the spermidine substrate.

253 Spermidine supplementation in T cells from old donors re

254 Spermidine supplementation of the medium did not circumv

255 Spermidine supplementation restored this pathway and imp

256 ic flux by treating cells with the polyamine spermidine suppresses prion formation in mutants that no

257 er-Robinson Syndrome (SRS) exhibit deficient Spermidine Synthase (SMS) gene expression, which causes

258 When cyclohexylamine, a spermidine synthase (SPDS) inhibitor, was added at the s

259 parasite virulence, a cell line deficient in spermidine synthase (SPDSYN), the enzyme that converts p

260 nosylmethionine decarboxylase (AdoMetDC) and spermidine synthase (SpdSyn).

261 Mechanistically, ABHD5 suppresses spermidine synthase (SRM)-dependent spermidine productio

262 We have expressed a yeast spermidine synthase (ySpdSyn) gene under constitutive (C

263 num lycopersicum) lines overexpressing yeast spermidine synthase (ySpdSyn), an enzyme involved in pol

264 Treatment of cells with a spermidine synthase inhibitor increased spermidine uptak

265 iling revealed that the enzymatic product of spermidine synthase, spermidine, cycles as well.

266 shown that both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosyn

267 ve genes, namely ornithine decarboxylase and spermidine synthase, were induced by GABA in plants grow

268 lations, such as ornithine decarboxylase and spermidine synthase.

269 of stored SPDS mRNAs, leading to substantial spermidine synthesis in the spermatids.

270 ncentration of MTA (10 muM), a by-product of spermidine synthesis, enhances the inhibition of SPD at

271 ne (Gsp) and trypanothione (bis(glutathionyl)spermidine (T(SH)2)).

272 A with more than two amine groups (spermine, spermidine), the removal rate was close to 100% for all

273 Upon addition of spermine and spermidine, the characteristic surface plasmon resonance

274 At high concentrations of spermidine, this condensation significantly increases th

275 yhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the

276 FN-gamma signaling, upon coadministration of spermidine to IFN-gamma-treated cells.

277 In the group that received DFMO/sulindac, spermidine-to-spermine ratio (Spd:Spm) in rectal mucosa

278 e under stress conditions and for preventing spermidine toxicity.

279 Thus, Dur3p and Dur31p are preferential spermidine transporters used by Hst 5 for its entry into

280 After spermidine treatment, activated T cells lacking the auto

281 ed to polarizing cytokines, with and without spermidine treatment, to evaluate CD4(+) T-cell differen

282 ine, phenylethylamine, putrescine, spermine, spermidine, tyramine and tryptamine) in fish tissues.

283 eG is the enzyme responsible for acetylating spermidine under stress conditions and for preventing sp

284 th a spermidine synthase inhibitor increased spermidine uptake and Hst 5 killing, whereas protonophor

285 We found spermidine uptake and Hst 5 mediated killing were decrea

286 eas protonophores and cold treatment reduced spermidine uptake.

287 train increased Hst 5 sensitivity and higher spermidine uptake.

288 The increase in spermidine was accompanied by reduced levels of nicotina

289 o investigate whether activation of TCPTP by spermidine was capable of alleviating IFN-gamma-induced,

290 ave not been reported before, and dicaffeoyl spermidine was detected in high abundance in the extract

291 Spermidine was the prevailing polyamine in caprine sampl

292 SYN), the enzyme that converts putrescine to spermidine, was created by double-targeted gene replacem

293 gene, CV86, proposed to act on monoacylated spermidines, was isolated and partially characterized.

294 The contents of spermine and spermidine were low and did not exceed the values of 35

295 g concentrations of putrescine, spermine and spermidine were observed with chilled ageing period and

296 Spermine and spermidine were the prevalent amines (100%), followed by

297 ls of individuals with SRS accumulate excess spermidine, whereas spermine levels are reduced.

298 aled elevated levels of many amino acids and spermidine, which links the induction of autophagy in Ma

299 gation of Tyr-Au NPs induced by spermine and spermidine, which results to restore fluorescence of Tyr

300 scripts of rpoS were elevated in response to spermidine, which was correlated with increased protein