ライフサイエンスコーパス: spermine

1 ase, and spermine synthase) and reduction of spermine.

2 These plants also contain high levels of spermine.

3 rae showed that it acetylates spermidine and spermine.

4 eroxide from the catabolism of the polyamine spermine.

5 nzyme A to polyamines such as spermidine and spermine.

6 to the CP-AMPAR antagonist 1-naphthyl acetyl spermine.

7 with respect to the reaction spermidine --> spermine.

8 which function is to convert spermidine into spermine.

9 nd decreases only an order of magnitude with spermine.

10 may relate to the antioxidant properties of spermine.

11 ations of divalent cations and the polyamine spermine.

12 rescine and cadaverine but not spermidine or spermine.

13 recorded in situ but blocked the effects of spermine.

14 itive with respect to the substrates DAP and spermine.

15 le changes in gene expression in response to spermine.

16 r than those formed in buffer or buffer plus spermine.

17 n inability to biosynthesize spermidine, and spermine.

18 induction and gene regulation in response to spermine.

19 s adjacent to these elements were induced by spermine.

20 ified the attraction of ovulatory females to spermine.

21 the side chain of Glu92 and the N1 amine of spermine.

22 chains of Glu92, Asp93, and the N4 amine of spermine.

23 hate, nicotinamide adenine dinucleotide, and spermine.

24 ally through catabolism of spermidine and/or spermine.

25 plex with coenzyme A, with and without bound spermine.

26 ates a structurally altered binding site for spermine.

27 re isolated from selection plates containing spermine.

28 (0.1-1.8), N(1),N(14)-bis-(dihydrocaffeoyl) spermine (0.2-1.7), N(1),N(10)-bis-(dihydrocaffeoyl) spe

29 ed the PIP(2)-induced inward current by 69%; spermine (100 microM) reduced the current by 97%.

30 With the exception of spermidine and spermine a wide variation of BA levels was observed amon

31 ctions between duplex DNA in the presence of spermine, a biological polycation.

32 y in cells was also shown to be inhibited by spermine, a porin inhibitor, although in an in vitro ass

33 tabolic enzymes of the polyamine pathway and spermine abundance in 120 well-characterized cases of hu

34 and 19F NMR data show that 1 mM SDS and 1 mM spermine accelerate aggregation compared to buffer alone

35 Spermidine/spermine acetyltransferase (SAT1) is the rate-limiting e

36 cell migration through binding of spermidine/spermine acetyltransferase (SSAT) to the alpha9 cytoplas

37 egulation of the degrading enzyme spermidine/spermine acetyltransferase.

38 We found spermine activated a trace amine-associated receptor (TA

39 Here, we report that spermine acts as an exogenous cue that inhibits V. chole

40 ed NspS protein could bind spermine in vitro Spermine also inhibited biofilm formation by altering th

41 exporter that shows the highest affinity for spermine among the polyamines examined.

42 Binding of spermine, an allosteric potentiator, opens the amino-ter

43 We determined that spermine, an odorous polyamine initially identified from

44 Remarkably, slightly longer synthetic spermine analogs (BE-spermine, CGC-11098) significantly

45 noparticles compared to their non-degradable spermine analogues.

46 bove a critical concentration of tetravalent spermine and are stable over long times at room temperat

47 non-competitive manner with respect to both spermine and DAP.

48 -reaction depend on the aging time after the spermine and enzyme are mixed in a double-mixing experim

49 ture than the molecular aggregation inducers spermine and heparin.

50 cells are capable of transporting exogenous spermine and its analogs into the cell and, in response,

51 sensitivity to blockade by 1-naphthyl-acetyl-spermine and large single-channel conductances.

52 With both spermine and N(1)-acetylspermine as the amine substrate,

53 omyces cerevisiae catalyzes the oxidation of spermine and N(1)-acetylspermine to spermidine and 3-ami

54 USA300 and E. faecalis acetylate spermidine, spermine and norspermidine, that spermine is the more pr

55 Interactions between the polyamine spermine and nucleic acids drive important cellular proc

56 tation experiments on DNA in the presence of spermine and other condensing agents.

57 hich the ratio between the concentrations of spermine and oxygen is kept constant establishes the ste

58 idine, Triquat A, and Triquat 7; tetravalent spermine and Quatro-quat; and hexavalent Quatro-diquat.

59 gnificant positive effect of storage time on spermine and serotonin levels.

60 resent study, polyamine oxidase specific for spermine and spermidine and diamine oxidase specific for

61 Because spermine and spermidine are effective blockers of K(+) i

62 Here, we demonstrate that the polyamines spermine and spermidine are environmental signals that a

63 Our results indicate that spermine and spermidine are novel triggers to alert F. t

64 orimetric and fluorescence turn-on assays of spermine and spermidine in biological samples.

65 ive detection of prostatic cancer biomarkers spermine and spermidine in real clinical applications wi

66 at low Mg(2+) concentrations, the polyamines spermine and spermidine stimulate codon recognition by t

67 The contents of spermine and spermidine were low and did not exceed the

68 Increasing concentrations of putrescine, spermine and spermidine were observed with chilled agein

69 Spermine and spermidine were the prevalent amines (100%)

70 unknown substrates, such as polyamines (e.g. spermine and spermidine).

71 Upon addition of spermine and spermidine, the characteristic surface plas

72 ing the aggregation of Tyr-Au NPs induced by spermine and spermidine, which results to restore fluore

73 veral of the intermolecular contacts between spermine and the enzyme and form a "proton wire" between

74 natural polyamines (putrescine, spermidine, spermine) and polyamine-like potent OCT1 blockers (1,10-

75 e AMPAR antagonist [NASPM (1-naphthyl acetyl spermine)] and a specific phosphoinositide 3 kinase (PI3

76 nst the substrates 1,5-diaminopentane (DAP), spermine, and fibrillar type I collagen.

77 al mucosal levels of polyamines (spermidine, spermine, and putrescine) and PGE2, treatment regimens,

78 ion, conformational changes induced by urea, spermine, and sodium dodecyl sulfate (SDS), its interact

79 The polyamines putrescine, spermine, and spermidine are abundant within the gastroi

80 We find that both DAP and spermine are capable of activating LOXL2 to the same ext

81 Cationic polyamines such as spermidine and spermine are critical in all forms of life, as they regu

82 When small numbers of spermine are introduced, RNA with a designed sequence co

83 Polyamines such as spermidine and spermine are primordial polycations that are ubiquitousl

84 The polyamines putrescine, spermidine, and spermine are required for normal eukaryotic cellular fun

85 Putrescine, spermidine, and spermine are the polyamines required for human cell grow

86 Polyamines (putrescine, spermidine, and spermine) are major organic polycations essential for a

87 The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately involved

88 yamines, such as putrescine, spermidine, and spermine, are physiologically important polycations, but

89 ease in MPS patients, and support the use of spermine as a new biomarker to facilitate the developmen

90 AT is almost as efficient as human SSAT with spermine as substrate.

91 50-fold for both mutations; the effects with spermine as the substrate are smaller, 20-40-fold.

92 tamine, serotonine, tyramine, spermidine and spermine), as well as microbiological profile (lactic ac

93 oups from acetylcoenzyme A to spermidine and spermine, as part of a polyamine degradation pathway.

94 olecules in the cell despite the presence of spermine at concentrations high enough to precipitate DN

95 involved in the conversion of spermidine and spermine back to putrescine.

96 st likely due to depletion of spermidine and spermine, because stable polyamine analogs that are not

97 tic scheme in which weakly voltage-dependent spermine binding to a "shallow" site in the pore (presum

98 Here, we study the effect of spermine binding to short duplex RNA and DNA, and compar

99 contrast, for DNA, simulations suggest that spermine binds externally to the duplex, offering opport

100 inding sites in a Kir pore, and confirm that spermine binds stably at a deep site in the inner cavity

101 tion of methionine, leucine, spermidine, and spermine, but not putrescine.

102 Spermine, but not spermidine, enhanced NMDA-induced depo

103 Putrescine and spermine, but not spermidine, showed evidence of co-oper

104 of the polyamines putrescine, spermidine and spermine by controlling stability of the polyamine biosy

105 idence that 3'ddR5p derivatives generated by spermine-catalyzed strand cleavage at Ap sites in duplex

106 ightly longer synthetic spermine analogs (BE-spermine, CGC-11098) significantly increased the protect

107 tant for the slow step is independent of the spermine concentration, with a value of 5.5 s(-1), compa

108 In the absence of IHF, spermidine and spermine condense DNA primarily into toroidal structures

109 Spermine condenses DNA and some RNAs, such as poly(rA):p

110 been explored for the sensitive detection of spermine (considered as an excellent biomarker for early

111 ophenylhydrazone and methylamine, but not by spermine, consistent with an active transport process.

112 ree polyamines showed that only the triamine spermine could specifically rescue the S-dependent repro

113 examethasone spermine (DS) and disubstituted spermine (D(2)S), were tested as individual components a

114 15 h and then decreased after 24 h, whereas spermine decreased by 3.9-fold after 15 h.

115 after the onset of diabetes, an increase in spermine-dependent oxidation at proximal microvascular s

116 We conclude that spermine-dependent oxidation is a previously unrecognize

117 annels; in addition to a physiological role, spermine-dependent oxidation may also contribute to micr

118 In addition, our observation that spermine-dependent oxidation occurs predominately in the

119 electrophysiologically, based on measures of spermine-dependent rectification and CP-AMPAR blockade b

120 facilitation that arose from an activity and spermine-dependent unblock of GluR2-lacking receptors an

121 henolic glycosides, a monoterpene lactone, a spermine derivative, and fatty acids, could be identifie

122 ed macrophages is inhibited by the polyamine spermine derived from ornithine decarboxylase (ODC), and

123 Polyamines spermidine and spermine did not show statistically significant changes

124 The polyamines spermidine and spermine did not show statistically significant changes

125 anine from malonate semialdehyde, l-alanine, spermine, dihydrouracil, and acryloyl-coenzyme A (CoA).

126 However, dietary supplementation of spermine does not appear to benefit SRS patients or mous

127 vities of two cationic lipids, dexamethasone spermine (DS) and disubstituted spermine (D(2)S), were t

128 Synthalin did not block spermine enhancement of NMDA-induced depolarization of m

129 uN2B-selective positive allosteric modulator spermine enhances responses from GluN1/2B/2D but not Glu

130 uN2B-selective positive allosteric modulator spermine enhances responses from GluN1/2B/2D but not Glu

131 and its complexes with p-xylylenediamine and spermine establish the flexibility of the methylene brid

132 The k(cat)/K(M) value for spermine exhibits a bell-shaped pH profile, with an aver

133 dative stress via ATP13A2-mediated lysosomal spermine export.

134 of the CP-AMPAR antagonist 1-naphthyl acetyl spermine followed by a seeking test, or 3) systemic admi

135 f thymine acts as a steric block, relocating spermine from major grooves to interhelical regions, the

136 n at intermediate voltages, and exclusion of spermine from the pore at negative voltages.

137 this was also reversed by the production of spermine from the spermine synthase transgene.

138 tate the direct and noninvasive detection of spermine from urine rapidly and is likely to have great

139 The tetramine spermine has been reported to be present at nearly 50 mu

140 rofile is consistent with the active form of spermine having three charged nitrogens.

141 amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine and tryptamine) were deter

142 amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine, tryptamine and phenylethy

143 Putrescine, spermidine, and spermine (i.e., polyamines) are small cationic amines sy

144 iscovered an unanticipated and sole role for spermine in facilitating mucilage production by mitigati

145 rimetric assay to detect nanomolar levels of spermine in human urine (healthy donors, cancer patients

146 The content of spermidine and spermine in mammalian cells has important roles in prote

147 f the polyamines putrescine, spermidine, and spermine in mutant inflorescences.

148 Reduction of SMO by spermine in the absence of oxygen is biphasic.

149 omyces cerevisiae catalyzes the oxidation of spermine in the biosynthetic pathway for pantothenic aci

150 th NspS, as purified NspS protein could bind spermine in vitro Spermine also inhibited biofilm format

151 daverine) and two polyamines (spermidine and spermine) in 112 samples of dairy products purchased in

152 evealed a marked elevation of the polyamine, spermine, in affected animals, and gene therapy studies

153 imary function of polyamines, spermidine and spermine, in translation in mammalian cells.

154 2-lacking AMPAR antagonist, 1-naphthylacetyl spermine, indicative of an increased contribution of Glu

155 hodamine (TAMRA) with a metal surface, using spermine induced aggregated silver nanoparticles as the

156 We determined if spermine inhibits iNOS-mediated immunity by reducing L-A

157 ecreased by intra-NAc core 1-naphthyl acetyl spermine injection or systemic mGluR1 positive allosteri

158 mine oxidase (SMO) metabolizes the polyamine spermine into spermidine and generates H(2)O(2), which c

159 dase (SMOX), which metabolizes the polyamine spermine into spermidine plus H(2)O(2), is associated wi

160 al transporter ATP13A2 pumps polyamines like spermine into the cytosol, whereas ATP13A2 dysfunction c

161 packaged DNA length and through addition of spermine ions, we transform the interaction energy from

162 The observed protection profile of spermine is identical to that previously reported, with

163 ofiles with simulation results suggests that spermine is sequestered deep within the major groove of

164 spermidine, spermine and norspermidine, that spermine is the more preferred substrate, and that E. fa

165 th SRS accumulate excess spermidine, whereas spermine levels are reduced.

166 Low spermine levels were found in milk irrespective of SCC.

167 Our study reveals that spermine metabolism via redox buffering of the ER underp

168 the potential use of a metabolically stable spermine mimetic, (R,R)-1,12-dimethylspermine (Me(2)SPM)

169 The enzyme spermidine/spermine N (1)-acetyltransferase (SSAT) catalyzes the tr

170 Spermidine/spermine N(1)-acetyltransferase (SAT1) was co-immunoprec

171 permine (DENSpm), an activator of spermidine/spermine N(1)-acetyltransferase (SAT1).

172 ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1)

173 in a rapid induction of host cell spermidine/spermine N(1)-acetyltransferase 1 (hSSAT-1) mRNA, causin

174 ession of a key catabolic enzyme, spermidine/spermine N(1)-acetyltransferase 1 (SAT1) in mammalian ce

175 Spermidine/spermine N(1)-acetyltransferase 1 (SSAT1), which catalyz

176 Here, we identified the SAT1 (spermidine/spermine N(1)-acetyltransferase 1) gene as a transcripti

177 Spermidine/spermine N(1)-acetyltransferase 2 (SSAT2) or inactive SS

178 Moreover, P-S induces spermidine/spermine N(1)-acetyltransferase enzymatic activity, and

179 We show that spermidine/spermine N-acetyltransferase (SSAT) homologues encoded b

180 thaliana an early drought-induced spermidine spermine-N(1) -acetyltransferase homolog, which can slow

181 of the polyamine catabolic enzyme spermidine/spermine-N(1)-acetyltransferase (SSAT) in response to in

182 substrate of spermine oxidase and spermidine/spermine-N(1)-acetyltransferase (SSAT) when compared wit

183 Enhanced flux is driven by spermidine/spermine N1-acetyltransferase (SSAT) activity, which ace

184 s the first and regulatory enzyme spermidine/spermine N1-acetyltransferase (SSAT) in a polyamine cata

185 the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close proximity

186 Spermidine/spermine N1-acetyltransferase 1 (SAT1), the rate-limitin

187 of the catabolic polyamine enzyme spermidine/spermine N1-acetyltransferase 1 (SAT1).

188 ow that the blood levels of SAT1 (spermidine/spermine N1-acetyltransferase 1), the top biomarker iden

189 ogen induces an overexpression of spermidine/spermine N1-acetyltransferase, the rate-limiting enzyme

190 GluR2-lacking AMPARs with 1-naphthyl acetyl spermine (NAS) caused a greater reduction in the AMPAR-E

191 ith a specific antagonist, 1-naphthyl acetyl spermine (NASPM), reversed the apparent increase in AMPA

192 Mechanistically, spermine neutralized off-target oxygen free radicals pro

193 the presence of nitric oxide, delivered from spermine NONOate, or increased ectonucleotidase levels (

194 identical to that previously reported, with spermine occupancy inhibiting MTSEA modification of resi

195 hough in an in vitro assay, the influence of spermine on the activity of isolated NDM-1 protein is mi

196 olyamine analogs that are similar in size to spermine on the rate of MTSEA modification.

197 ontrol airways by the higher-order polyamine spermine or by cell-permeable PIP2, but these interventi

198 Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO

199 and polyamine precursors, supplementation of spermine or spermidine in the borrelial growth medium in

200 ing: (i) addition of putrescine, spermidine, spermine, or N(1)-AcSpd did not restore the expression o

201 Spermidine and spermine originate mainly from raw materials.

202 In mammalian cells, the flavoprotein spermine oxidase (SMO) catalyzes the oxidation of spermi

203 Spermine oxidase (SMO) is a polyamine catabolic enzyme t

204 th H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC.

205 Spermine oxidase (SMO) metabolizes the polyamine spermin

206 ng pathogen Helicobacter pylori up-regulates spermine oxidase (SMOX) in gastric epithelial cells, cau

207 The polyamine catabolic enzyme spermine oxidase (SMOX) is induced in chronic inflammato

208 During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydr

209 of the host response to H. pylori, and that spermine oxidase (SMOX), which metabolizes the polyamine

210 3,10-Me(2)Spm was a poor substrate of spermine oxidase and spermidine/spermine-N(1)-acetyltran

211 In contrast, host cell SSAT-2, spermine oxidase, and acetylpolyamine oxidase (hAPAO) re

212 is catalyzed by the mammalian polyamine and spermine oxidases.

213 Dietary polyamines spermidine and spermine participate in an array of physiological roles

214 Spermine, poly-D-lysine, and neomycin all reduced the ba

215 A large fraction of the spermine present in cells is bound to RNA but apparently

216 Spermine promoted the accumulation of camalexin by induc

217 The complex with spermine provides a direct view of substrate binding by

218 The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential cla

219 none/DFMO-induced MitoROS, whereas exogenous spermine quenched rotenone-induced MitoROS via ATP13A2.

220 p that received DFMO/sulindac, spermidine-to-spermine ratio (Spd:Spm) in rectal mucosa decreased betw

221 mphasize the importance of normal spermidine:spermine ratio in the hearing and balance functions of t

222 y studies demonstrated that reduction of CSF spermine reflects correction of brain lesions in these a

223 Polyamines, including spermine, regulate the interactions of F. tularensis wit

224 Growth of Pseudomonas aeruginosa on spermine requires a functional gamma-glutamylpolyamine s

225 Accumulation of polyphosphate granules and spermine resistance in the suppressor were reversed conc

226 es (75-124 and 11-24 mg/kg of spermidine and spermine, respectively).

227 mechanism of gene regulation controlled by a spermine-responsive promoter contained within IS element

228 identified FTL_0883 as a gene important for spermine responsiveness.

229 lar depletion of putrescine, spermidine, and spermine resulting in cellular growth arrest and eventua

230 Here we report that at concentrations of spermine several-fold higher the MT bundles (B(MT)) quic

231 sociated metabolites taurine, histamine, and spermine shape the host-microbiome interface by co-modul

232 olyamine spermidine or of another polyamine, spermine, significantly alters the ratio between target

233 d in frog motoneurons in situ and also for a spermine specific polyamine site on native NMDA receptor

234 hich have aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic (tyramine, phenylethylam

235 For BA with more than two amine groups (spermine, spermidine), the removal rate was close to 100

236 Eight biogenic amines (spermine, spermidine, putrescine, histamine, tyramine, p

237 ne, histamine, phenylethylamine, putrescine, spermine, spermidine, tyramine and tryptamine) in fish t

238 The spermine/spermidine ratio in lymphoblasts was 0.53, sign

239 rmine synthase show clearly that the correct spermine:spermidine ratio is critical for normal growth

240 Simulations carried out with Mg(2+) or spermine (SPM(4+)) show that these ions interact with po

241 Polyamines, including spermine (Spm) and spermidine (Spd), are aliphatic catio

242 The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations p

243 e (Put) and polyamines; spermidine (Spd) and spermine (Spm) are essential component of every cell bec

244 Finally, we determined spermine (SPM) sensitivity of these uncharacterized SNPs

245 PAO) was found to catalyse the conversion of spermine (Spm) to spermidine (Spd) in vitro.

246 related polyamines, norspermidine (NSP) and spermine (SPM), also inhibit amphibian lymphocyte prolif

247 ines: putrescine (Put), spermidine (Spd) and spermine (Spm), and their derivatives.

248 The effects of methyl jasmonate (MeJA), spermine (Spm), epibrassinolide (EBL) and l-phenylalanin

249 e of the most important biogenic polyamines; spermine (SPM), spermidine (SPD) and putrescine (PUT), o

250 DC and two metabolite ratios (citrate [Cit], spermine [Spm], and creatine [Cr] to choline [Cho] and C

251 At concentrations as low as 10-14 molar, spermine stimulated the lamprey olfactory system and att

252 Uptake of unchelated Cu is inhibited by spermine, suggesting a porin-dependent passive transport

253 onductance and strong block by intracellular spermine, suggesting that they were 'TARPless'.

254 Global c-di-GMP levels were unaffected by spermine supplementation, suggesting that biofilm format

255 caused by a significant decrease or loss of spermine synthase (SMS) activity.

256 caused by a loss-of-function mutation in the spermine synthase (SMS) gene.

257 Spermine synthase (SMS) is an enzyme which function is t

258 Loss-of-function mutations in spermine synthase (SMS), a polyamine biosynthesis enzyme

259 Here, we report that spermine synthase (SMS), a polyamine biosynthetic enzyme

260 tion Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine

261 ersed by the production of spermine from the spermine synthase transgene.

262 transgenic line that ubiquitously expresses spermine synthase under the control of a composite cytom

263 nzymes analyzed (ODC, polyamine oxidase, and spermine synthase) and reduction of spermine.

264 n in polyamine content due to the absence of spermine synthase, the product of the SpmS gene.

265 Mutant strains lacking the spermine synthase-encoding gene SPS1 progressed through

266 so prevented by the transgenic expression of spermine synthase.

267 clic polyamine disulfide was shown to be the spermine tetra-amine disulfide (TetraN-3,4,3).

268 mean concentrations showed greater levels of spermine than spermidine, except for the 5th day post-pa

269 We show, using sensitivity to intracellular spermine, that a similar switch occurs between P12 and P

270 N1-acetylspermine, N1-acetylspermidine, and spermine, the k(cat)/K(amine)-pH profiles are bell-shape

271 Not only subjected to growth inhibition by spermine, the pauA2 mutant became more sensitive to beta

272 no effect on the k(cat)/K(amine) profile for spermine; the k(red) value with N1-acetylspermine is onl

273 lyzes the N(1)-acetylation of spermidine and spermine to form acetyl derivatives, is a rate-limiting

274 ine oxidase (SMO) catalyzes the oxidation of spermine to spermidine and 3-aminopropanal.

275 nd scavenging capacity; ii) high contents of spermine, total biogenic amines and total polyamines; an

276 o rapid depletion of cellular spermidine and spermine, total inhibition of protein synthesis, and gro

277 as a potential protection mechanism against spermine toxicity.

278 , and N(1),N(5),N(14)-tris-(dihydrocaffeoyl) spermine (trace - 11.1).

279 sed amino acid, lysine-trimethylene(diNosyl)-spermine(triBoc) with Dde or Fmoc orthogonal protecting

280 transformation pathway, which results from a spermine-triggered conformation switch from straight to

281 Consistent with this, 1-naphthylacetyl spermine trihydrochloride (NASPM), an antagonist of GluA

282 y the GluR inhibitor NASPM (1-naphthylacetyl spermine trihydrochloride).

283 aying inward tail currents are elicited upon spermine unbinding.

284 Interestingly, fluorescently labeled spermine uptake in the mitochondria dropped as a consequ

285 on and CP-AMPAR blockade by 1-naphtyl acetyl spermine using recordings from synaptically connected ce

286 In humans, CSF spermine was elevated in neuropathic subtypes of MPS (MP

287 neurons from MPS I mice showed that elevated spermine was essential for the abnormal neurite overgrow

288 In MPS I patients, elevated CSF spermine was restricted to patients with genotypes assoc

289 Spermine was sufficient to activate transcription of the

290 hypoxanthine, and PAO catalysed oxidation of spermine, was coupled to horseradish peroxidase conversi

291 ryptamine, beta-phenylethylamine spermidine, spermine were analysed by UV detection after pre-column

292 tamine, dopamine, serotonin, spermidine, and spermine were decreased during the ripening process in t

293 Putrescine, spermidine and spermine were measured as dansylated derivatives by high

294 tyramine) and two polyamines (spermidine and spermine) were detected in cocoa beans during fermentati

295 dine and phenylethylamine to 0.2mgkg(-1) for spermine) when compared to FD (from 1mgkg(-1) for putres

296 Cheese from all SCC categories contained spermine; whereas tyramine and tryptamine were only dete

297 und for putrescine (and hence spermidine and spermine), which was proposed to convert into 4-aminobut

298 Spermidine and spermine, which enhance duplex stability, inhibited tran

299 of these channels is driven by the polyamine spermine, whose catabolism produces oxidants.

300 bably occurs through a direct interaction of spermine with NspS, as purified NspS protein could bind