ライフサイエンスコーパス: sphingomyelinase

1 ngomyelin (acid sphingomyelinase and neutral sphingomyelinase).

2 by interfering with membrane-associated acid sphingomyelinase).

3 with an on-tissue digestion by ceramidase or sphingomyelinase.

4 lls were treated with exogenous ceramide and sphingomyelinase.

5 mide, and manumycin, an inhibitor of neutral sphingomyelinase.

6 tment of cells with 25-hydroxycholesterol or sphingomyelinase.

7 ation of voltage-gated K+ (Kv) channels by a sphingomyelinase.

8 matrix degradation mediated by IL-1, TNF, or sphingomyelinase.

9 gers the activation of acid, but not neutral sphingomyelinase.

10 icrotiter assay was developed using purified sphingomyelinase.

11 cause of the activation of enzymes like acid sphingomyelinase.

12 rt-dependent pathway and is mediated by acid sphingomyelinase.

13 locked by pharmacological inhibition of acid sphingomyelinase.

14 ion of cholesterol and inhibition of neutral sphingomyelinase.

15 te function and expression of ceramidase and sphingomyelinase.

16 regulated by lipids such as cholesterol and sphingomyelinase.

17 h is prevented by genetic deficiency of acid sphingomyelinase.

18 ced or restored by extracellular exposure to sphingomyelinase.

19 mmatory signaling in HRECs by downregulating sphingomyelinases.

20 The level of SM is tightly regulated by sphingomyelinases.

21 r, by the silencing or inhibition of neutral sphingomyelinase 2 (nSMase-2) using shRNAi, scyphostatin

22 uires the LC3-conjugation machinery, neutral sphingomyelinase 2 (nSMase2) and LC3-dependent recruitme

23 Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of s

24 Neutral sphingomyelinase 2 (nSMase2) is one of the key enzymes r

25 We previously presented that the neutral sphingomyelinase 2 (nSMase2) is the only SMase activated

26 Neutral sphingomyelinase 2 (nSMase2) produces the bioactive lipi

27 Neutral sphingomyelinase 2 (nSMase2) was identified as responsib

28 Neutral sphingomyelinase 2 (nSMase2), encoded by the Smpd3 gene,

29 bserved in astrocytes with deficient neutral sphingomyelinase 2 (nSMase2), indicating that ceramide g

30 3 gene coding for the active site of neutral sphingomyelinase 2 (NSMase2), secreted increased amounts

31 Neutral sphingomyelinase 2 (nSMase2, product of the SMPD3 gene)

32 nduces ceramide accumulation through neutral sphingomyelinase 2 and that ceramides shift the Bcl-x 5'

33 x 5'SS selection in INS-1 cells, and neutral sphingomyelinase 2 inactivation only partially prevented

34 s by inhibiting ceramide synthase or neutral sphingomyelinase 2 leads to translocation of membrane-bo

35 lated protein 2, Janus kinase 3, and neutral sphingomyelinase 2 proteins localized to breast tumor en

36 s for the ceramide-generating enzyme neutral sphingomyelinase 2.

37 PP2A activation by IL-1beta involved neutral sphingomyelinase-2 (NSMase-2) and an accumulation of cer

38 ion of the plasma membrane localized neutral sphingomyelinase-2 (NSMase-2).

39 locked by inhibition or silencing of neutral sphingomyelinase-2 (nSMase2).

40 Since neutral sphingomyelinase-2 (nSMase2: SMPD3) is a key enzyme for

41 ral exosome secretion due to lack of neutral sphingomyelinase-2 function, that ceramide-enriched exos

42 cation of a sphingomyelin hydrolase (neutral sphingomyelinase-2) to the plasma membrane.

43 on variants in SMPD4, coding for the neutral sphingomyelinase-3 (nSMase-3/SMPD4).

44 tisense knockdown of N-SMase, but not acidic sphingomyelinase (A-SMase), suggests that soluble produc

45 tabolism, including a fatty acid elongase, a sphingomyelinase, a phosphate acyltransferase, and a pat

46 Sphingomyelin breakdown as a result of sphingomyelinase activation after ligation of a variety

47 ly, bilirubin triggered rapid Ca(2+) influx, sphingomyelinase activation, formation of ceramide, and

48 Factor associated with neutral sphingomyelinase activity (FAN) is an adaptor protein th

49 Ablation of sphingomyelinase activity also interfered with the abili

50 through the regulation of pH-dependent acid-sphingomyelinase activity and of RhoA-dependent transpor

51 (5) integrin, leading to suppression of acid sphingomyelinase activity and preventing ceramide-mediat

52 rophil-mediated lung injury through both its sphingomyelinase activity and syndecan-1.

53 's hemolytic activity is consistent with its sphingomyelinase activity and the observation that Rv088

54 that the Mtb protein Rv0888 possesses potent sphingomyelinase activity cleaving sphingomyelin, a majo

55 However, mutant beta-toxin mice deficient in sphingomyelinase activity failed to trigger features of

56 Acid sphingomyelinase activity in pRBCs was associated with t

57 The sphingomyelinase activity of phospholipase D was necessa

58 hemolysis and lymphotoxicity, are due to the sphingomyelinase activity of the enzyme.

59 We mimicked the effect of sphingomyelinase activity on lipid mixtures of palmitoyl

60 These studies provide evidence that acid sphingomyelinase activity plays an essential role in the

61 s favor an indirect mechanism involving acid sphingomyelinase activity rather than a direct interacti

62 However, increased neutral sphingomyelinase activity was observed in hepatocytes fr

63 s as biofilm ligase activity, independent of sphingomyelinase activity) producing an insoluble nucleo

64 t of pRBCs with amitriptyline inhibited acid sphingomyelinase activity, ceramide accumulation, and mi

65 irements for cellular sphingomyelin and acid sphingomyelinase activity.IMPORTANCE Bovine herpesvirus

66 ur group demonstrated that secretion of acid sphingomyelinase acts upstream of ERM dephosphorylation,

67 catalyzed by the intestinal enzyme alkaline sphingomyelinase (alk-SMase, NPP7, ENPP7).

68 otecting cells by mediating the secretion of sphingomyelinase, an enzyme that reduces the number of a

69 e, we demonstrate that beta toxin, a neutral sphingomyelinase and a virulence factor of S. aureus, fo

70 rticles might stimulate the activity of acid sphingomyelinase and activate the apoptotic machinery.

71 eep red blood cells by Staphylococcus aureus sphingomyelinase and CAMP factor (cohemolysin), a secret

72 s that was dependent on expression of acidic sphingomyelinase and CD95.

73 ide was primarily due to the actions of acid sphingomyelinase and ceramide synthase LASS 5, demonstra

74 ihydroceramides along with elevation of acid sphingomyelinase and CerS5 activities.

75 ins of S. aureus, induces activation of acid sphingomyelinase and concomitant release of ceramide in

76 however, combined inhibition of both acidic sphingomyelinase and de novo ceramide generation was req

77 nd via the hydrolysis of sphingomyelin (acid sphingomyelinase and neutral sphingomyelinase).

78 In this study, the requirement for acid sphingomyelinase and sphingomyelin metabolites in the TN

79 cal relevance under conditions in which both sphingomyelinases and phospholipase A(2) enzymes are act

80 , lipid/raft perturbations (cyclodextrin and sphingomyelinase), and bleb formation.

81 Arachidonic acid activates the acid sphingomyelinase, and inhibition of acid sphingomyelinas

82 ncrease in serine palmitoyltransferase, acid sphingomyelinase, and neutral sphingomyelinase mRNA, pro

83 red exocytosis of lysosomes, release of acid sphingomyelinase, and rapid lesion removal by caveolar e

84 ention such as lipoprotein lipase, secretory sphingomyelinase, and secretory phospholipase A2.

85 mily A, member 12), glucocerebrosidase, acid sphingomyelinase, and transglutaminase 1.

86 inds 125I-PFO* only after SM is destroyed by sphingomyelinase; and (3) a residual pool that does not

87 yeast two-hybrid screen and identified acid sphingomyelinase as a novel intracellular signaling path

88 ism mediated by activation of secretory acid sphingomyelinase, as suggested by experiments with neutr

89 th CD161, and this association augments acid sphingomyelinase (ASM) activity upon stimulation of CD4(

90 disease (NPD) is caused by the loss of acid sphingomyelinase (ASM) activity, which results in widesp

91 rage disorder caused by a deficiency in acid sphingomyelinase (ASM) activity.

92 embranes and subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM i

93 rt that ceramide and its related enzyme acid sphingomyelinase (ASM) are secreted by irradiated endoth

94 We have identified acid sphingomyelinase (ASM) as an important player in the ear

95 r a targeted deletion (knockout) of the acid sphingomyelinase (ASM) gene (called ASMKO mice), a faith

96 Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceram

97 Acid sphingomyelinase (ASM) is a key regulator of the sphingo

98 In mammals, acid sphingomyelinase (ASM) is an enzyme that hydrolyzes sphi

99 Acid sphingomyelinase (ASM) is an important early responder i

100 We show that acid sphingomyelinase (ASM) is increased in fibroblasts, brai

101 key enzyme in sphingolipid metabolism, acid sphingomyelinase (ASM) is involved in the regulation of

102 tudy, we show that the lysosomal enzyme acid sphingomyelinase (ASM) is released extracellularly when

103 The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of

104 Acid sphingomyelinase (ASM) is the lipid hydrolase that is de

105 Acid sphingomyelinase (ASM) mediates the formation of membran

106 Here we show that inhibition of acid sphingomyelinase (ASM) mislocalizes both the K-Ras isofo

107 Acid sphingomyelinase (ASM) released from lysosomes induces e

108 nt exocytosis of lysosomes, delivery of acid sphingomyelinase (ASM) to the outer leaflet of the plasm

109 tudy was performed to determine whether acid sphingomyelinase (Asm), a ceramide-producing enzyme, is

110 In particular, acid sphingomyelinase (ASM), a critical enzyme in the product

111 vestigated humans and mice deficient in acid sphingomyelinase (ASM), an enzyme that degrades sphingom

112 s been previously shown to activate the acid sphingomyelinase (Asm)/ceramide system.

113 Acid sphingomyelinase (ASM; E.C. 3.1.4.12) is best known for

114 /or a critical enzyme of TNF signaling, acid sphingomyelinase (ASMase(-/-)).

115 g pathways, the molecular mechanisms of acid sphingomyelinase (ASMase) activation remain poorly under

116 radiation, and chemotherapies, activate acid sphingomyelinase (ASMase) and generate the second messen

117 Acid sphingomyelinase (ASMase) and neutral sphingomyelinase (

118 ortilin is critical for the delivery of acid sphingomyelinase (ASMase) and required for efficient pha

119 of C(16)-ceramide due to activation of acid sphingomyelinase (ASMase) and sphingomyelin hydrolysis.

120 cocerebrosidase (beta-GlcCer'ase) and acidic sphingomyelinase (aSMase) catalytic activity and enzyme

121 Acid sphingomyelinase (aSMase) catalyzes the hydrolysis of sp

122 l and bis(monoacylglycero)phosphate, an acid sphingomyelinase (ASMase) cofactor, within the RPE.

123 Acid sphingomyelinase (ASMase) converts the lipid sphingomyel

124 Pharmacological inhibition of acid sphingomyelinase (aSMase) decreased anti-DENV NS1 Ab-med

125 required the ceramide-synthesis enzyme acid sphingomyelinase (aSMase) for their release, an enzyme w

126 The acid sphingomyelinase (aSMase) gene gives rise to two distinc

127 Acid sphingomyelinase (aSMase) generates the bioactive lipid

128 Acid sphingomyelinase (ASMase) has been proposed to mediate l

129 The putative acid sphingomyelinase (ASMase) inhibitor imipramine inhibited

130 Translocation of the secretory form of acid sphingomyelinase (ASMase) into microscopic rafts generat

131 ave focused on stress mediators such as acid sphingomyelinase (ASMase) or protein kinase Cdelta (PKCd

132 A defect in acid sphingomyelinase (ASMase) results in SM storage and subs

133 l storage disease caused by the loss of acid sphingomyelinase (ASMase) that features neurodegeneratio

134 An overactivation of sphingomyelinase (ASMase) was noted in the treated cells

135 Acid sphingomyelinase (ASMase)(-/-) mice exhibit LC accumulat

136 ine, a frequently employed inhibitor of acid sphingomyelinase (ASMase), blocked PGE(2) production.

137 mice with pharmacological inhibitors of acid sphingomyelinase (ASMase), desipramine and imipramine, a

138 sipramine and imipramine, inhibitors of acid sphingomyelinase (ASMase), suppressed RGDfV-induced cera

139 Because cisplatin activates acid sphingomyelinase (ASMase), we investigate here the role

140 vani promastigotes induce activation of acid sphingomyelinase (ASMase), which catalyzes the formation

141 these defense mechanisms by activating acid sphingomyelinase (ASMase), which increases tubulin acety

142 tor superfamily receptors might involve acid sphingomyelinase (ASMase)-mediated ceramide generation,

143 he well characterized lysosomal enzyme, acid sphingomyelinase (ASMase).

144 ion (neutral sphingomyelinase [NSMase], acid sphingomyelinase [ASMase], and serine-palmitoyl-transfer

145 ASMase and NSMase activity was determined by sphingomyelinase assay in primary cultures of HRECs.

146 ASM activity was determined using Amplex Red sphingomyelinase assay.

147 ic lipids, we employed recombinant bacterial sphingomyelinase (bSMase) as a direct probe of SM metabo

148 Treatment of cells with Bacillus cereus sphingomyelinase (bSMase) increases the overall ceramide

149 pended on Ca(2+) and the activity of neutral sphingomyelinase but not clathrin-coated pit maturation.

150 provide evidence that SMPDL3A is not an acid sphingomyelinase but unexpectedly is active against nucl

151 kle cell disease enhance the activation acid sphingomyelinase by 13%, resulting in increased producti

152 Activation of acid sphingomyelinase by alpha-toxin is mediated via ADAM10.

153 Inhibition of acid sphingomyelinase by NB-19 before addition of POVPC compl

154 lavoprotein (6.m00467), lysozyme (6.m00454), sphingomyelinase C (29.m00231), and a hypothetical prote

155 Sphingomyelinase C (SMase) inhibits CFTR chloride channe

156 depletion of sphingomyelin by inhibitors or sphingomyelinase caused plasma membrane remodeling, lead

157 The addition of sphingomyelinase, ceramide, or a proteasome inhibitor al

158 fferent terminals is mediated by the neutral sphingomyelinase/ceramide signaling pathway.

159 icate a novel and important role of the acid sphingomyelinase/ceramide system for the endothelial res

160 he phosphatidylinositol 3-kinase and neutral sphingomyelinase chemical inhibitors, Ly294002 and GW486

161 ing to the presence of a venom enzyme called sphingomyelinase D (SMaseD).

162 myelin depletion, as shown using recombinant sphingomyelinase D.

163 abbits injected with purified or recombinant sphingomyelinase D2, Paixao-Cavalcante et al. propose in

164 diseases Niemann-Pick type C (NPC) and acid sphingomyelinase deficiency (ASM), in patient cells and

165 Ceramide depletion, by myriocin or neutral sphingomyelinase deficiency (fro/fro mouse), led to GSK3

166 delivery of a model therapeutic cargo (acid sphingomyelinase, deficient in Niemann-Pick disease A-B)

167 zing ceramide antibody in mice and with acid sphingomyelinase-deficient fibroblasts.

168 in contrast to asm(+/+)/ldlr(-/-), the acid sphingomyelinase-deficient littermates did not display h

169 acid sphingomyelinase, or obtained from acid sphingomyelinase-deficient mice, and lung inflammation w

170 RBCs treated with amitriptyline or from acid sphingomyelinase-deficient mice.

171 To test this association in vivo, acid sphingomyelinase deletion (asm(-/-)) was transferred to

172 vo characterization of the T. brucei neutral sphingomyelinase demonstrates that it is directly involv

173 hrough a caspase-mediated process), the acid sphingomyelinase-dependent generation of ceramide, and p

174 ne protein with a surface-exposed C-terminal sphingomyelinase domain and a putative N-terminal channe

175 beta-toxin is a sphingomyelinase encoded for by virtually all S. aureus

176 We also show that acid sphingomyelinase enhances RBC-derived microparticle (MP)

177 Finally, we determined that sphingomyelinase enzymatic activity directly prevents al

178 bination with novel on-tissue ceramidase and sphingomyelinase enzyme digestions makes it now possible

179 alpha-Toxin heptamer formation and acid sphingomyelinase expression were determined by means of

180 donic acid and sequential activation of acid sphingomyelinase for the generation of ceramide within t

181 Substantial homologies to sphingomyelinases from other leptospiras and other bacte

182 Sphingomyelinases generate ceramide from sphingomyelin a

183 vage pathway of ceramide formation, and acid sphingomyelinase has been implicated, in part, in provid

184 ns of the functional inhibitors of host acid sphingomyelinase, imipramine and amitriptyline, which in

185 d-type strain reveal that activation of acid sphingomyelinase in endothelial cells requires alpha-tox

186 onic acid and highlight the role of the acid sphingomyelinase in microparticle-induced apoptosis of e

187 imed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed

188 d activity level in HRECs, and inhibition of sphingomyelinases in endothelial cells prevents cytokine

189 -1) was independent of both host SM and acid sphingomyelinase, in a manner similar to BoHV-1.

190 e examined the role of beta-toxin, a neutral sphingomyelinase, in S. aureus-induced lung injury.

191 n D-inhibiting drug alisporivir and the acid sphingomyelinase-inactivating drug, desipramine, synergi

192 In contrast, inhibition of cellular acid sphingomyelinase inhibited PRV entry.

193 Treatment of BoHV-1 particles with sphingomyelinase inhibited viral entry activity, suggest

194 Neutral sphingomyelinase inhibition caused accumulation of miR-1

195 Acid sphingomyelinase inhibition in stored pRBCs offers a nov

196 h T cell activation; this was abolished upon sphingomyelinase inhibition.

197 Finally, the acidic sphingomyelinase inhibitor desipramine attenuated HDACI/

198 carbocyclic core of the naturally occurring sphingomyelinase inhibitor scyphostatin, from the readil

199 n export via exosomes, which is blocked by a sphingomyelinase inhibitor, GW4869.

200 ery disease incubated with GW4869, a neutral sphingomyelinase inhibitor, whereas polyethylene glycol-

201 Exosome biogenesis/release was blocked using sphingomyelinase inhibitor.

202 by phosphatidylinositol 3-kinase and neutral sphingomyelinase inhibitors.

203 ein with CD4 and coreceptor, we propose that sphingomyelinase inhibits HIV infection by inducing CD4

204 ly, we reported that treatment of cells with sphingomyelinase inhibits human immunodeficiency virus t

205 rm of the parasite indicate that the neutral sphingomyelinase is essential for growth and survival, t

206 Activation of acid sphingomyelinase is linked to degradation of tight junct

207 e establish that an NPA patient and the acid sphingomyelinase knockout (ASMko) mouse model show amoeb

208 Acid sphingomyelinase knockout mice are a model of the inheri

209 ives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory sphingomyelinas

210 ives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory sphingomyelinas

211 enzymes, beta-glucocerebrosidase and acidic sphingomyelinase, leading to accelerated maturation of S

212 ly secrete a physiologic level of apoE) with sphingomyelinase led to a reduction of apoE secretion by

213 ucing BRB permeability in part by modulating sphingomyelinase levels.

214 The enzyme acid sphingomyelinase-like phosphodiesterase 3B (SMPDL3B) was

215 Sphingomyelinase-like phosphodiesterase 3b mediates radi

216 he data also suggest that inhibition of acid sphingomyelinase may provide a novel treatment option to

217 distinct dual-target mechanism, linking acid sphingomyelinase-mediated (ASMase-mediated) microvascula

218 eability transition pore formation, and acid sphingomyelinase-mediated ceramide production.

219 Acid (ASMase) and neutral (NSMase) sphingomyelinase mRNA levels and activity were measured

220 nsferase, acid sphingomyelinase, and neutral sphingomyelinase mRNA, providing a mechanistic link for

221 t study underlines the importance of neutral sphingomyelinase (N-SMase) in mediating the damaging eff

222 astroglia induced the activation of neutral sphingomyelinase (N-SMase), production of ceramide, and

223 The neutral sphingomyelinases (N-SMases) are considered major candid

224 Neutral sphingomyelinases (N-SMases) are major candidates for st

225 Neutral sphingomyelinases (N-SMases) are major candidates for st

226 Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in i

227 (mSREBP-1), phosphorylated Akt, and neutral sphingomyelinase (NSMase) are higher, relative abundance

228 Acid sphingomyelinase (ASMase) and neutral sphingomyelinase (NSMase) are key regulatory enzymes of

229 Inhibition of neutral sphingomyelinase (nSMase) blocked HPV, whereas exogenous

230 Neutral sphingomyelinase (NSMase) has been proposed to mediate i

231 ) machinery, although an alternative neutral sphingomyelinase (nSMase) pathway has been suggested to

232 t both message and protein levels of neutral sphingomyelinase (NSMase), which hydrolyzes sphingomyeli

233 mes involved in ceramide generation (neutral sphingomyelinase [NSMase], acid sphingomyelinase [ASMase

234 The neutral sphingomyelinases (nSMases) are considered major candida

235 Hence, we propose to name Rv0888 as SpmT (sphingomyelinase of Mycobacterium tuberculosis).

236 This structure is similar to that of the sphingomyelinases of Listeria ivanovii and Bacillus cere

237 vo exposure to hyperosmotic shock, bacterial sphingomyelinase or C6 ceramide.

238 Inhibition of acidic sphingomyelinase or de novo ceramide generation blocked

239 Release of endogenous ceramides via sphingomyelinase or exogenous ceramide treatments dose-d

240 Down-regulation of either acid sphingomyelinase or LASS 5-attenuated ceramide accumulat

241 ramide to the bath, by addition of bacterial sphingomyelinase, or by hypertonic stress, S358 is rapid

242 mitriptyline, a functional inhibitor of acid sphingomyelinase, or obtained from acid sphingomyelinase

243 e release using GW4869 to target the neutral sphingomyelinase pathway induced a decrease in intercell

244 The sphingomyelinase pathway rather than ceramide de novo sy

245 exogenously added S1P did not stimulate the sphingomyelinase pathway; however, added [(3)H]S1P was h

246 first report of sphingomyelin and lysosomal sphingomyelinase playing a role in the entry of a herpes

247 Acid sphingomyelinase plays important roles in ceramide homeo

248 cid sphingomyelinase, and inhibition of acid sphingomyelinase prevents microparticle-induced apoptosi

249 ereas the addition of exogenous ceramides or sphingomyelinase reduces the differences.

250 eriments with hepatocytes revealed that acid sphingomyelinase regulates the partitioning of the major

251 d genetic blockade of cyclophilin D and acid sphingomyelinase renders the high TNF state hyperresista

252 The sphingomyelinases represent the catabolic pathway for N-

253 igher delivery of a therapeutic enzyme, acid sphingomyelinase, required for types A and B Niemann-Pic

254 the yeast homologue of the mammalian neutral sphingomyelinase, resulted in an increased sensitivity t

255 nd the enzymatic breakdown of sphingomyelin (sphingomyelinase), results in significant changes in the

256 mal sphingomyelinase (L-SMase) and secretory sphingomyelinase (S-SMase) via alternative trafficking o

257 mal sphingomyelinase (L-SMase) and secretory sphingomyelinase (S-SMase), via differential trafficking

258 Beta toxin is a neutral sphingomyelinase secreted by certain strains of Staphylo

259 Sphingomyelinases secreted by pathogenic bacteria play i

260 c events including cytokine release and acid sphingomyelinase secretion.

261 fter incubation with cholesterol oxidase and sphingomyelinase show that these two enzymes disrupt the

262 ed membrane bending energy elicits a neutral sphingomyelinase (SMase) activity in human erythrocytes.

263 It secretes sphingomyelinase (SMase) C that can suppress CFTR activi

264 Sphingomyelinase (SMase) catalyzes the degradation of sp

265 ngomyelin to ceramide by exogenous bacterial sphingomyelinase (SMase) protected against the endocytos

266 articular chondrocytes were stimulated with sphingomyelinase (SMase) to increase levels of endogenou

267 hemical changes that decrease levels of acid sphingomyelinase (SMase), an enzyme that cleaves sphingo

268 SMs) are plasma membrane lipids that undergo sphingomyelinase (SMase)-mediated hydrolysis in the lyso

269 es accessible by treatment with SM-degrading sphingomyelinase (SMase).

270 * unless the sphingomyelin is destroyed with sphingomyelinase (SMase).

271 Here, we report that sphingomyelinases (SMase) from human respiratory pathoge

272 ived from the hydrolysis of sphingomyelin by sphingomyelinases (SMases) and implicated in diverse cel

273 Sphingomyelinases (SMases) hydrolyze membrane sphingomye

274 ocalization and activity of neutral and acid sphingomyelinases (SMases), resulting in elevated cellul

275 Levels of SM are regulated by sphingomyelinases (SMases).

276 Activation of acid sphingomyelinase (SMPD1) and the generation of ceramide

277 d Cer decrease, which are controlled by acid sphingomyelinase (SMPD1).

278 Neutral sphingomyelinase SMPD3 (nSMase2), a sphingomyelin phosph

279 SMPD3 deficiency in the neutral sphingomyelinase (Smpd3(-/-)) mouse results in a novel f

280 Notably, extracellular addition of sphingomyelinase stimulates host cell endocytosis, enhan

281 centrations of Staphylococcus aureus-derived sphingomyelinase successfully reduced cell surface-expos

282 itor, SR33557, but not inhibitors of neutral sphingomyelinase, suppressed RGDfV-induced apoptosis, su

283 )/Podo(Cre), that also lacks Smpd1, the acid sphingomyelinase that hydrolyzes sphingomyelin to cerami

284 Biochemical purification of neutral sphingomyelinases that correlated with MOMP sensitizatio

285 DNase I folding superfamily; in addition to sphingomyelinases, the proteins most structurally relate

286 gents or by the addition of recombinant acid sphingomyelinase to the culture media, and the corrected

287 Furthermore, sphingomyelinase treatment did not affect the membrane d

288 e decrease in CD4 lateral mobility following sphingomyelinase treatment in terms of clustering of CD4

289 ation of fusion intermediates indicated that sphingomyelinase treatment inhibited HIV at a step in th

290 Notably, sphingomyelinase treatment of cells did not influence gp

291 diffusion of CD4 decreased 4-fold following sphingomyelinase treatment, while the effective diffusio

292 pool that does not bind 125I-PFO* even after sphingomyelinase treatment.

293 Exogenous C(6)-ceramide and sphingomyelinase treatments mimicked the influence of do

294 Wounding or exposure to sphingomyelinase triggered endocytosis and intracellular

295 phospholipases, aspartyl proteases, and acid sphingomyelinases) was found in the M. globosa genome.

296 vasoconstriction and responses to exogenous sphingomyelinase were increased, whereas the responses t

297 We show that CCN1 activates neutral sphingomyelinase, which functions as a key source of CCN

298 ch is mutated in Batten disease type 1, acid sphingomyelinase, which is mutated in Niemann Pick disea

299 strate for the lysosome-resident enzyme acid sphingomyelinase, which plays a role in cell membrane re

300 Consistently, inhibition of acid sphingomyelinase with imipramine disrupts ACEC formation