ライフサイエンスコーパス: spinal cord

1 of excitatory synapses throughout the lumbar spinal cord.

2 ential targets to improve self-repair of the spinal cord.

3 the lesion site of completely transected rat spinal cord.

4 ed MBP ligand in the brain compared with the spinal cord.

5 NMDARs and their synaptic trafficking in the spinal cord.

6 r matrix that ligate the severed ends of the spinal cord.

7 nt inhibition between motoneurons within the spinal cord.

8 ted cells across the transverse plane of the spinal cord.

9 orks whose activity patterns resemble intact spinal cord.

10 ons act downstream of Npr1(+) neurons in the spinal cord.

11 s hmx3b, hmx1, and hmx4 are not expressed in spinal cord.

12 ion can influence the signals that enter the spinal cord.

13 es this activity is found in the lumbosacral spinal cord.

14 by inhibiting AMPA and NMDA receptors in the spinal cord.

15 ith a profound hypoperfusion of the inflamed spinal cord.

16 in all four reticular nuclei, but not in the spinal cord.

17 and translation regulation signaling in the spinal cord.

18 the white matter of the motor cortex and the spinal cord.

19 the loss of motor neurons from the brain and spinal cord.

20 ly identified peptides mediating itch in the spinal cord.

21 anosensory stimuli are represented along the spinal cord.

22 ral spinal nucleus (LSN), of mouse and human spinal cord.

23 and lower motor neurons within the brain and spinal cord.

24 ecular anatomy of the LUT-related circuit in spinal cord.

25 al root entry zone (DREZ) to extend into the spinal cord.

26 f presynaptic and postsynaptic NMDARs in the spinal cord.

27 neurogenesis profiles of V3 INs in the mouse spinal cord.

28 xpressing LJA5 neurons through the brain and spinal cord.

29 in the optic nerve, corpus callosum, and the spinal cord.

30 oot ganglia (DRG) and the dorsal horn of the spinal cord.

31 ntricular organ and the central canal of the spinal cord.

32 m the brain through the central canal of the spinal cord.

33 nal trigeminal nucleus and all levels of the spinal cord.

34 ") to evaluate tissue samples from the C2-C6 spinal cord 3 days after a C3/C4 hemi-crush injury (C3Hc

35 multiple sclerosis (MS), knowledge about how spinal cord abnormalities translate into clinical manife

36 , real-time, continuous objective measure of spinal cord activation in response to therapy via record

37 med to examine pain relief and the extent of spinal cord activation with ECAP-controlled closed-loop

38 in transmission of voluntary commands to the spinal cord after damage (e.g., after stroke or spinal c

39 The spinal cord also expresses all dopamine receptors; howev

40 extending from the graft into the denervated spinal cord also triggered local host neuronal network r

41 embling the cerebral cortex or the hindbrain/spinal cord and assemble them with human skeletal muscle

42 jects to undergo 7 T imaging of the cervical spinal cord and brain as well as conventional 3 T brain

43 d 16.11% alpha-tubulin acetylation for mouse spinal cord and brain homogenate tissue, respectively, a

44 Scale, white matter lesion fractions in the spinal cord and brain of the 9-Hole Peg Test and cortica

45 etween the colon and central nervous system (spinal cord and brain) that underlies the gut-brain axis

46 as sympathetic preganglionic neurons in the spinal cord and central targets of primary sensory affer

47 4 inhibits immune-cell infiltration into the spinal cord and completely abrogates immune responses to

48 pression in the midbrain-hindbrain boundary, spinal cord and dorsal root ganglia.

49 rvous system (CNS) encompasses the brain and spinal cord and is considered the processing center and

50 ating a common progenitor cell for posterior spinal cord and muscle enables the formation of function

51 We demonstrate that GBF1 is present in mouse spinal cord and muscle tissues and is particularly abund

52 ctivation of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and z

53 re often severe and predominantly affect the spinal cord and optic nerve.

54 Conclusion Gadolinium was retained in the spinal cord and peripheral nerves in rats exposed to mul

55 ount of alpha2delta-1-GluN1 complexes in the spinal cord and the level of alpha2delta-1-bound GluN1 p

56 sychosine levels in the rodent brainstem and spinal cord, and a significantly shorter life-span of th

57 carry pain signals from the meninges to the spinal cord, and if so, to what extent and through which

58 gnaling triggers the release of Wnt5a in the spinal cord, and inhibition of spinal Wnt5a signaling at

59 rvous system (CNS), consisting of the brain, spinal cord, and retina, superintends to the acquisition

60 um), diencephalon, mesencephalon, hindbrain, spinal cord, and retina.

61 udies demonstrate that CS projections to the spinal cord are eliminated in an activity-dependent mann

62 ful in this perspective, but studies for the spinal cord are lacking.

63 CANCE STATEMENT Ependymal cells in the adult spinal cord are latent progenitors that react to injury

64 Neurons within the spinal cord are sensitive to environmental relations and

65 ntromedial, and away from the ventrolateral, spinal cord as the frequency of fictive locomotion incre

66 inflammatory leukocytes were present in the spinal cord at peak disease (day 14 postimmunization; i.

67 is optica spectrum disorders, focal areas of spinal cord atrophy at MRI were topographically associat

68 itically review the application of brain and spinal cord atrophy in clinical practice in the manageme

69 can be quantified by estimation of brain and spinal cord atrophy with MRI.

70 euroinflammation and disruption of the blood spinal cord barrier (BSCB) was also observed.

71 ng to the existence of the BBB and the blood-spinal cord barrier have been terrible and threatening c

72 ine inhibited AQP4 localization to the blood-spinal cord barrier, ablated CNS edema, and led to accel

73 Spinal cord blood vessels of CMH-treated mice showed red

74 dulated by projections from the brain to the spinal cord, but the neural substrates for top-down sens

75 matosensory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory in

76 the center controlling locomotion within the spinal cord can produce a backward pattern when instruct

77 ssion through distinct pathways in different spinal cord cell types and further implicate the importa

78 Swelling of the brain or spinal cord (CNS edema) affects millions of people every

79 p in the diagnostic algorithm is to rule out spinal cord compression before evaluating other causes o

80 Baseline spinal cord corticospinal tracts lesion volume fraction

81 The spinal cord corticospinal tracts lesion volume fraction

82 However, correlation with spinal cord cross-sectional area-a predictor of disabili

83 fraction from neuronal tissue lysates after spinal cord crush injury of mice.

84 functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spat

85 Purpose To identify MRI features of cervical spinal cord damage that could help predict disability an

86 ein prevents immune-cell infiltration in the spinal cord, decreases integrin expression in antigen-sp

87 he door to further investigations in vivo of spinal cord dendritic spine dynamics in the context of i

88 Grafting embryonic spinal cord-derived NSCs or injury alone served as 2 con

89 Grafts of spinal-cord-derived neural progenitor cells (NPCs) enabl

90 eatures of excitatory synapses in the lumbar spinal cord, detailing synaptic diversity that is depend

91 However, Hmx functions in spinal cord development have not been analyzed.

92 dendritic spine steady-state behavior in the spinal cord dorsal horn; and (3) this work opens the doo

93 expression of programmed-death-ligand-1) in spinal cord-draining lymph nodes and decreases the numbe

94 detect PI16 expression in neurons or glia in spinal cord, DRG, and nerve.

95 LPSx4, reactive microglia frequently contact spinal cord endothelial cells.

96 nd that inhibiting Hsp90 specifically in the spinal cord enhanced the antinociceptive effects of morp

97 the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organ

98 g" of nociceptive circuits in the developing spinal cord, following injuries during the neonatal peri

99 ng early-stage serotonergic neurons into the spinal cord for cardiovascular functional recovery after

100 ors by protecting mitochondria and hence the spinal cord from secondary injury.

101 hondria from oxidative stress, and hence the spinal cord from secondary injury.

102 e ependyma changes after injury of the adult spinal cord, functionally resembling the immature active

103 thesis that sensorimotor circuits within the spinal cord generate backward locomotion and adjust it t

104 Recently, cytokine interactions in brain and spinal cord glia as well as dorsal root ganglia satellit

105 generating axons to penetrate the inhibitory spinal cord glial scar.

106 viral vector induced pig model of high-grade spinal cord glioma and may potentially be used in precli

107 dy, we report the production of a high-grade spinal cord glioma model in pigs using lentiviral gene t

108 redictors of EDSS score in PMS were cervical spinal cord GM CSA and brain GM volume (R(2) = 0.44).

109 stic regression analysis identified cervical spinal cord GM CSA and T2 lesion volume as independent p

110 Cervical spinal cord GM lesions may subsequently cause GM atrophy

111 in cholesterol synthesis, was reduced in the spinal cord GM of ALS patients.

112 erol levels are elevated several-fold in the spinal cord GM of male sporadic ALS patients.

113 eostasis is adversely affected in the in the spinal cord gray matter (GM), and if so, whether it is b

114 matic nuclei, anterior olfactory nuclei, and spinal cord gray matter.

115 Lesion fractions within the spinal cord grey and white matter were related to the le

116 e 9-Hole Peg Test and cortical thickness and spinal cord grey matter cross-sectional area of the Time

117 Cervical spinal cord imaging at 7 T was used to segment grey and

118 and practical tool for clinical quantitative spinal cord imaging.

119 RNA sequencing analysis of mouse spinal cord in chronic itch models induced by squaric ac

120 ell-related signaling spreads to the DRG and spinal cord in females, but remains localized to the sci

121 t a single session of TESS over the cervical spinal cord in individuals with incomplete chronic cervi

122 n sortilin expressing cells (sixfold) and in spinal cord in mice (twofold).

123 pinal tracts from the cortex to the cervical spinal cord in patients with various disease phenotypes

124 fictive locomotion when bath-applied in the spinal cord in vitro.

125 cific CD8+ T cells exacerbated brain but not spinal cord inflammation.

126 TF1A, and reduced numbers of specific dorsal spinal cord inhibitory neurons, particularly those expre

127 pathways of protection in heart, brain, and spinal cord injuries.

128 5 (18.88) years) with subacute (ie, 1 month) spinal cord injury (25 patients with neuropathic pain, 1

129 ection to spinal motor neurons from ischemic spinal cord injury (ISCI).

130 Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), examination.

131 ll (NSPC) grafts can integrate into sites of spinal cord injury (SCI) and generate neuronal relays ac

132 Spinal cord injury (SCI) causes immune dysfunction, incr

133 Spinal cord injury (SCI) is a common cause of disability

134 Chronic pain caused by spinal cord injury (SCI) is notoriously resistant to tre

135 or muscle injury, but the Acomys response to spinal cord injury (SCI) is unknown.

136 munity long after SCI.SIGNIFICANCE STATEMENT Spinal cord injury (SCI) significantly disrupts immunity

137 c neuropathic pain is a major comorbidity of spinal cord injury (SCI), affecting up to 70-80% of pati

138 In spinal cord injury (SCI), the initial damage leads to a

139 of a million individuals in the US live with spinal cord injury (SCI).

140 promotes recovery of function in humans with spinal cord injury (SCI).

141 subjects with neurogenic bladder (NB) due to spinal cord injury (SCI).

142 promotes functional recovery in humans with spinal cord injury (SCI).

143 ical deficits and long-term disability after spinal cord injury (SCI).

144 tors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the c

145 ues in healthy animals or safety concerns in spinal cord injury animals.

146 atent stem cell niche that is reactivated by spinal cord injury contributing new cells to the glial s

147 Using a mouse model of ischemic spinal cord injury in male and female mice, we show that

148 Spinal cord injury in mammals is thought to trigger scar

149 This study investigates the response to spinal cord injury in the gray short-tailed opossum (Mon

150 spinothalamic tract function-at 1 month post-spinal cord injury is associated with the emergence and

151 growth and functional recovery in vivo in a spinal cord injury model through a unique mechanism of a

152 Inhibition of calmodulin in a rat spinal cord injury model with the licensed drug trifluop

153 Spinal cord injury remains a scientific and therapeutic

154 mber of individuals with cervical incomplete spinal cord injury show limited functional recovery of e

155 and preclinical research has used models of spinal cord injury to better elucidate the underlying me

156 ic incomplete cervical, thoracic, and lumbar spinal cord injury were randomly assigned to 10 sessions

157 , it presents as a potential therapeutic for spinal cord injury with evidence for behavioural improve

158 PCMS without exercise in 13 individuals with spinal cord injury with similar characteristics.

159 al axons and restore forelimb function after spinal cord injury(1); however, the molecular mechanisms

160 nal cord after damage (e.g., after stroke or spinal cord injury), possibly assisting recovery of func

161 rly complete recovery of neonatal mice after spinal cord injury, and suggest strategies that could be

162 er, patients with impaired voiding following spinal cord injury, patients undergoing nonurologic surg

163 cerebellar ataxia, Alzheimer's disease, and spinal cord injury, respectively.

164 After CNS trauma such as spinal cord injury, the ability of surviving neural elem

165 As rats are used extensively to model spinal cord injury, we asked if the S1 CST response is c

166 r organs, including the spleen, resulting in spinal cord injury-induced immunodeficiency.

167 igration and functional repair in vivo after spinal cord injury.

168 different degrees of paralysis and levels of spinal cord injury.

169 owth-competent axons after sciatic nerve and spinal cord injury.

170 for cardiovascular functional recovery after spinal cord injury.

171 te whether ED peptide has similar effects in spinal cord injury.

172 during the chronic phase following traumatic spinal cord injury.

173 ar dysfunction often occurs after high-level spinal cord injury.

174 wth of injured pathways in non-human primate spinal cord injury.

175 ian central nervous system trauma, including spinal cord injury.

176 w flexor and extensor muscles after cervical spinal cord injury.

177 ndamental to reestablish motor control after spinal-cord injury (SCI).

178 chwann cell precursors that migrate from the spinal cord into the intestine.

179 al itch circuitry.SIGNIFICANCE STATEMENT The spinal cord is a critical hub for processing somatosenso

180 The ependyma of the adult spinal cord is a latent stem cell niche that is reactiva

181 ive plasticity of neurons in lamina I of the spinal cord is a lynchpin for the development of chronic

182 and how itch signals are encoded within the spinal cord is not fully understood.

183 , in rats, release of oxytocin in the lumbar spinal cord is not limited to conventional synapses but

184 SNs) are interconnected across the brain and spinal cord is unclear.

185 nerated by a neural network, situated in the spinal cord, known as the locomotor central pattern gene

186 within subcellular compartments of male rat spinal cord lamina I neurons.

187 h antigen-presenting cells (APCs) within the spinal cord leptomeninges in experimental autoimmune enc

188 Despite the prevalence of cervical spinal cord lesions and atrophy, brain pathology seems m

189 d male sex, younger age, and the presence of spinal cord lesions as independent factors that increase

190 These findings show that spinal cord lesions involve both grey and white matter f

191 e sclerosis showed a greater predominance of spinal cord lesions nearer the outer subpial surface com

192 oglia treated with peptidase inhibitors into spinal cord lesions of adult mice, and found that both t

193 Cervical spinal cord lesions were mapped voxel-wise as a function

194 al bands, infratentorial lesions on MRI, and spinal cord lesions, were baseline independent predictor

195 f presynaptic and postsynaptic NMDARs at the spinal cord level and that presynaptic NMDARs play a pro

196 a signaling in nociceptive modulation at the spinal cord level.

197 ion) the peripheral nociceptive input at the spinal cord level.

198 1b synthesis attenuates nerve injury-induced spinal cord microglia activation and pain hypersensitivi

199 Spinal cord microglia contribute to nerve injury-induced

200 a cross talk is necessary for eliciting this spinal cord microglia phenotype and also for conferring

201 days (LPSx4) consistently elicit a reactive spinal cord microglia response marked by dramatic morpho

202 w that it is possible to consistently elicit spinal cord microglia via systemic delivery of inflammog

203 tical for nerve injury-induced activation of spinal cord microglia, but the responsible endogenous TL

204 As the resident macrophages of the brain and spinal cord, microglia are crucial for the phagocytosis

205 Moreover, by quantitative immunostaining of spinal cord MNs, we found corresponding protein level ch

206 Conclusion Cervical spinal cord MRI involvement has a central role in explai

207 tudy evaluated three-dimensional T1-weighted spinal cord MRI scans in seropositive participants with

208 Cervical spinal cord MRI was performed with three-dimensional (3D

209 In the zebrafish spinal cord, neural progenitors form stereotypic pattern

210 cytochrome c activities, leading to reduced spinal cord neuronal cell apoptosis and smaller lesion a

211 nd prevents degeneration of cultured primary spinal cord neurons derived from SMA mice.

212 o replicate this finding in primary cultured spinal cord neurons, spinal cord slice, and Xenopus laev

213 cuits restoring locomotion in mice following spinal cord neurostimulation.

214 ast-enhancing focal lesions in the brain and spinal cord observed on MRI.

215 bidirectionality in the central canal of the spinal cord of 30 hpf zebrafish embryos and its impact o

216 opathology in the developing mouse brain and spinal cord of both sexes.

217 Ectopic CSF-cNs in the spinal cord of C57Bl/6N mice emerge during whole period

218 erlie the ectopic position of CSF-cNs in the spinal cord of C57Bl/6N mice.

219 al and the adult (P > 90) normal and injured spinal cord of male and female mice.

220 number of ectopic CSF-cNs is present also in spinal cord of other investigated experimental mice stra

221 ein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum o

222 Tandem mass tagged proteomic analysis of the spinal cord of Ppt1(-/-)and control mice at these timepo

223 ion of cholesterol synthesis occurred in the spinal cord of SOD1(G93A) mice; levels of sterol regulat

224 n in specific white matter tracts within the spinal cord of squirrel monkeys following traumatic inju

225 We further observed in the spinal cords of EAE B(regs)-treated mice that CNS reside

226 ve the same mitochondrial function as in the spinal cords of sham control animals, it significantly a

227 Further, immunohistochemical analyses of the spinal cords of treated animals showed significantly low

228 Diseases of the spinal cord often have devastating consequences and imag

229 In the developing spinal cord, Onecut transcription factors control the di

230 es do not cause loss of motor neurons in the spinal cord or denervation at the neuromuscular junction

231 uromuscular junction, peripheral nerves, the spinal cord or the brain and discuss the autoimmune mech

232 site to monitor intraspinal pressure (ISP), spinal cord perfusion pressure (SCPP), tissue metabolism

233 extrahypothalamic brain areas and the lumbar spinal cord play an important role in the control of ere

234 Spinal cord pMN progenitors sequentially produce motor n

235 Brain, brainstem and spinal cord portions of the corticospinal tracts were id

236 spinal tracts along the brain, brainstem and spinal cord portions to explain physical disability in m

237 ecific Trpa1 disruption in a mouse brainstem-spinal cord preparation impedes the amplitude augmentati

238 r activity of various frequencies in upright spinal cords prepared from male and female neonatal mice

239 s demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in m

240 .0001), brainstem (r = 0.45, P < 0.0001) and spinal cord (r = 0.57, P < 0.0001) corticospinal tracts.

241 n and colleagues demonstrated that zebrafish spinal cord radial glia differentiate into cells that ar

242 sh and mice have long-range projections into spinal cord regions harboring Mc4r-expressing V2a intern

243 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run.

244 dorsal column lesions (DCLs) in the cervical spinal cord relies on neural rewiring in the cuneate nuc

245 ubstrate for touch-to-itch conversion in the spinal cord remains elusive.

246 rgets for interventions to improve brain and spinal cord remyelination, paving the way for the transl

247 anical mechanisms contributing to successful spinal cord repair in adult zebrafish are, however, curr

248 e studies into the role of mechanosensing in spinal cord repair.

249 natures of the dorsal root ganglia (DRG) and spinal cord response, not observed at the nerve injectio

250 ion of ZIKV infection in the mouse brain and spinal cord resulting in massive neurodegeneration of in

251 MENT Following unilateral hemisection of the spinal cord, reticulospinal projections are destroyed on

252 Spinal cord (SC) contributions to the slower components

253 otor neuron dysfunction in vivo by comparing spinal cord (SC) transcriptomes reported from TDP-43 and

254 n females, after cystometry c-Fos neurons in spinal cord segments L5-S2 were concentrated in the sacr

255 ing in primary cultured spinal cord neurons, spinal cord slice, and Xenopus laevis oocytes expressing

256 aviors with two-photon microscopy in ex vivo spinal cord slices from CX3CR1-GFP mice complemented wit

257 Enhancing the efficacy of spinal cord stimulation (SCS) is needed to alleviate the

258 Spinal cord stimulation (SCS) is the most utilized invas

259 ple with upper-limb amputation that epidural spinal cord stimulation (SCS), a common clinical techniq

260 d closed-loop versus fixed-output, open-loop spinal cord stimulation for the treatment of chronic bac

261 Spinal cord stimulation has been an established treatmen

262 A novel spinal cord stimulation system provides the first in viv

263 l pain relief up to 12 months than open-loop spinal cord stimulation.

264 ubstance P, pERK, and MMP-1; p <= 0.039) and spinal cord (substance P and MMP-1; p <= 0.041).

265 The terminal ileum and thoracic spinal cord (T(11)) were sampled for evaluating ileitis

266 transcutaneous electrical stimulation of the spinal cord (TESS) promotes functional recovery in human

267 transcutaneous electrical stimulation of the spinal cord (TESS) promotes recovery of function in huma

268 In the spinal cord, the central canal forms through a poorly un

269 n inhibition increases NMDAR activity in the spinal cord, the underlying mechanism remains enigmatic.

270 contrast, adult zebrafish are able to repair spinal cord tissue and restore motor function after comp

271 ive mapping of the spatiotemporal changes of spinal cord tissue stiffness in regenerating adult zebra

272 During regeneration after transection, the spinal cord tissues displayed a significant increase of

273 NK cells in post-mortem ALS motor cortex and spinal cord tissues, and the expression of NKG2D ligands

274 ect CB2 upregulation on postmortem human ALS spinal cord tissues.

275 through descending pathways to hindbrain and spinal cord to activate muscle and generate movement.

276 rability of the ventral motor neurons of the spinal cord to decreased SMN.

277 vivo two-photon Ca(2+) imaging of the mouse spinal cord to establish that NK1R and the gastrin-relea

278 he deep layers of M1 that send output to the spinal cord to support movement, imagined movements evok

279 , temperature and touch information from the spinal cord to the brain(1-4).

280 switch redirected disease pathology from the spinal cord to the brain.

281 ctile and noxious cutaneous signals from the spinal cord to the lateral parabrachial nucleus of the p

282 cells/progenitors (RN-NSCs) into a complete spinal cord transection lesion site in adult female rats

283 ue and restore motor function after complete spinal cord transection owing to a complex cellular resp

284 e injury (n = 64, 21.9%) including brain and spinal cord trauma.

285 We show NK1R mRNA expression in human spinal cord, underscoring the translational relevance of

286 Similarly, myelination in the spinal cord was disorganized after exposure at 2 dpf but

287 he dorsal white matter tract of the cervical spinal cord, we found that both lesioned dorsal and inta

288 MT images of the cervical spinal cord were collected parallel to the intervertebra

289 Labeling throughout the brainstem and spinal cord were very similar for the two antibodies and

290 t 12-13 or 19 weeks of age, and their lumbar spinal cords were processed for histo- and immunohistoch

291 curs proximal to degenerating neurons in the spinal cord, what causes it, and whether it contributes

292 nd that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types

293 fers from the striatum, locus coeruleus, and spinal cord, where multiple peptidases metabolize enkeph

294 of the kinase RSK in the dorsal horns of the spinal cord, which are heavily populated with primary af

295 g projection specifically to lamina I of the spinal cord, which transmits afferent pain, temperature,

296 ipsilateral projections of CS neurons in the spinal cord, while other studies demonstrate that CS pro

297 homogeneous delivery throughout the cervical spinal cord white and gray matter and brain motor center

298 nd microglia activation were observed in the spinal cord white matter of 7-month-old Hri(-/-) mice as

299 MENT Interneuron (IN) diversity empowers the spinal cord with the computation flexibility required to

300 IP3R) and estrogen receptor co-regulation in spinal cord yielded Ca(2+)-dependent nociceptive signali