ライフサイエンスコーパス: spindle assembly checkpoint

1 s, the mitotic checkpoint (also known as the spindle assembly checkpoint).

2 hase of the cell cycle, independently of the spindle assembly checkpoint.

3 ndle disruptions cause the engagement of the spindle assembly checkpoint.

4 , thereby resulting in the activation of the spindle assembly checkpoint.

5 ential roles in chromosome alignment and the spindle assembly checkpoint.

6 llels with the mode of action of Mad2 in the spindle assembly checkpoint.

7 ubule polymerization and satisfaction of the spindle assembly checkpoint.

8 tive microtubule nucleation pathways and the spindle assembly checkpoint.

9 7(C70R) mutation does not affect the mitotic spindle assembly checkpoint.

10 ts contribution seems to be relevant for the spindle assembly checkpoint.

11 d in G2 phase and mitosis, suggesting a weak spindle assembly checkpoint.

12 D2L1) in a screen for genes required for the spindle assembly checkpoint.

13 damage response, whereas Mps1 regulates the spindle assembly checkpoint.

14 phase-anaphase transition, controlled by the spindle assembly checkpoint.

15 re-microtubule associations and regulate the spindle assembly checkpoint.

16 Moreover, a lack of CK2 activates the spindle assembly checkpoint.

17 ule lattice and, thus, the activation of the spindle assembly checkpoint.

18 ids, the tel1 mec1 diploids had a functional spindle assembly checkpoint.

19 Mps1 is an essential component of the spindle assembly checkpoint.

20 depends on a surveillance system called the spindle assembly checkpoint.

21 t interact with spindle microtubules and the spindle assembly checkpoint.

22 ning methods by applying them to the mitotic spindle assembly checkpoint.

23 to mitotic stress by abrogating the mitotic spindle assembly checkpoint.

24 actor transmitting the tension status to the spindle assembly checkpoint.

25 has also been implicated in inactivating the spindle assembly checkpoint.

26 hromatin staining, indicative of an extended spindle assembly checkpoint.

27 ssion of Mad2, an essential component of the spindle assembly checkpoint.

28 rylates KNL1, BUB1, and MAD1 to initiate the spindle assembly checkpoint.

29 chromosome segregation, and attenuating the spindle assembly checkpoint.

30 , kinetochore-microtubule attachment and the spindle assembly checkpoint.

31 d load-bearing capacity and silencing of the spindle assembly checkpoint.

32 be induced in the mouse by inactivating the spindle assembly checkpoint.

33 ase and is one of the main components of the spindle assembly checkpoint.

34 hts the contribution of p53 in regulation of spindle assembly checkpoint.

35 ependent regulation of MT attachment and the spindle-assembly checkpoint.

36 checkpoints and a recently reported mitotic spindle-assembly checkpoint.

37 ansient activation of the S phase, G2/M, and spindle assembly checkpoints.

38 detailed knowledge of the components of the spindle assembly checkpoint, a molecular explanation of

39 ons cause microcephaly and KNL1 mediates the spindle assembly checkpoint, a safeguard against chromos

40 The spindle assembly checkpoint, a surveillance mechanism th

41 kinetochore-microtubule attachment, mitotic/spindle-assembly checkpoint, accurate chromosome segrega

42 y regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling protein

43 vels of KT proteins, including CENP-C(Cnp3), spindle assembly checkpoint activation, and chromosome s

44 itotic progression is halted attributable to spindle assembly checkpoint activation, and chromosomes

45 ly, inhibition of Net1 expression results in spindle assembly checkpoint activation.

46 e mediated by wee1 and are not the result of spindle assembly checkpoint activation.

47 ctured tail region is defective in mediating spindle assembly checkpoint activation.

48 hromosome segregation through regulating the spindle assembly checkpoint activity, and cyclin B1 and

49 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stab

50 in p31(comet) is implicated in silencing the spindle assembly checkpoint after all kinetochores are a

51 Additional mechanisms, such as the spindle assembly checkpoint and centromere positioning,

52 fects in mitotic spindle formation, cellular spindle assembly checkpoint and centrosome amplification

53 Besides its role in the spindle assembly checkpoint and chromosome alignment, Bu

54 Further study showed that inactivation of spindle assembly checkpoint and degradation of Cyclin B1

55 found that FA signaling is essential for the spindle assembly checkpoint and is therefore required fo

56 -expression of survivin restores a competent spindle assembly checkpoint and reduces polyploidy.

57 cells undergo normal mitoses with an intact spindle assembly checkpoint and that they are able to co

58 llmark of cancer, due to attenuations in the spindle assembly checkpoint and the post-mitotic checkpo

59 These findings show that inhibition of spindle assembly checkpoints and chromosomal organizing

60 APC(Cdc20), antimitotic agents activate the spindle-assembly checkpoint and induce apoptosis after p

61 ct chromosome alignment and segregation, the spindle assembly checkpoint, and cytokinesis.

62 e-induced G2/M cell cycle checkpoint and the spindle assembly checkpoint, and nothing is known about

63 on, arrested cells in mitosis, activated the spindle assembly checkpoint, and triggered mitotic catas

64 Whereas the kinetochores and the spindle assembly checkpoint appeared intact in HDAC3-def

65 at DNA damage-induced wild-type p53 leads to spindle assembly checkpoint arrest by repressing UBE2C,

66 The spindle assembly checkpoint arrests mitotic cells by pre

67 The spindle assembly checkpoint arrests mitotic progression

68 comet), a negative regulator of MAD2 and the spindle assembly checkpoint, as an important mediator of

69 nisms such as abrogation of G2/M and mitotic spindle assembly checkpoints, as well as impaired induct

70 metaphase plate, possibly due to a defective spindle-assembly checkpoint, as well as of frayed and un

71 appear to rely on several components of the spindle assembly checkpoint but does require the kinetoc

72 etochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its k

73 reviously undescribed regulatory role in the spindle assembly checkpoint by recruiting Plk1 to kineto

74 ), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitoti

75 INPP5E in human and murine cells impairs the spindle assembly checkpoint, centrosome and spindle func

76 The spindle assembly checkpoint complex (SAC) is essential f

77 me instability (W-CIN) we down-regulated the spindle assembly checkpoint component BUB1 and the mitot

78 adipogenesis, DNA replication, mitosis, and spindle assembly checkpoint control were all highly repr

79 The spindle assembly checkpoint controls proper chromosome s

80 dle poles, we identified novel roles for the spindle assembly checkpoint, cortical actin cytoskeleton

81 TRIP13 action in vitro, and in cells causes spindle assembly checkpoint defects consistent with loss

82 The spindle assembly checkpoint delays APC/C-Cdc20 activatio

83 The mitotic checkpoint, also known as the spindle assembly checkpoint, delays anaphase onset until

84 nt centromere cohesion defects that maintain spindle assembly checkpoint-dependent mitotic arrest in

85 proper chromosome alignment, resulting in a spindle assembly checkpoint-dependent mitotic delay.

86 stmitotic checkpoint after adaptation to the spindle assembly checkpoint, E7-expressing cells replica

87 ated that genetic disruptions of the mitotic spindle assembly checkpoint elevate expression of PDR-me

88 The spindle assembly checkpoint enables this centering mecha

89 The spindle assembly checkpoint ensures the faithful inherit

90 rmation of a bipolar mitotic spindle and the spindle assembly checkpoint, ensuring proper spindle fun

91 , but maintains kinetochore localization and spindle assembly checkpoint function, indicating that TP

92 By depolymerizing microtubules and mutating spindle assembly checkpoint function, we demonstrate tha

93 troduced into the monopolar spindle 1 (Mps1) spindle-assembly checkpoint gene so that Cre-mediated re

94 sufficiency or heterozygous mutations in the spindle assembly checkpoint genes BUB1 and BUB3 in 2.9%

95 Spindle assembly checkpoint governs proper chromosomal s

96 Variation in the activity of the spindle assembly checkpoint has been observed in differe

97 ne H3 plays a crucial role in activating the spindle assembly checkpoint in response to a defect in m

98 rom separase during meiosis I or support the spindle assembly checkpoint in yeast.

99 t with a role for dynein in self-removal and spindle assembly checkpoint inactivation.

100 By treating embryos with a spindle assembly checkpoint inhibitor during the four- t

101 Silencing of the spindle assembly checkpoint involves two protein phospha

102 Despite this, the spindle assembly checkpoint is normally silenced and the

103 findings establish that in mammalian MI, the spindle assembly checkpoint is unable to sustain meiotic

104 ipts also indicated that the strength of the spindle assembly checkpoint is weakened and that higher

105 The mitotic checkpoint (or spindle assembly checkpoint) is a fail-safe mechanism to

106 The spindle assembly checkpoint kinase Mps1 not only inhibit

107 ctivity of DDR kinases ATM and Chk1, and the spindle assembly checkpoint kinase Mps1.

108 ne-121 site on histone H2A, a target of Bub1 spindle assembly checkpoint kinase, sensitizes gammaH2A-

109 with NHEJ deficiency upon disruption are two spindle assembly checkpoint kinases, Bub1 and Bub2.

110 The spindle assembly checkpoint links the onset of anaphase

111 The spindle assembly checkpoint monitors microtubule attachm

112 ed to the spindle, kinetochores activate the spindle assembly checkpoint network, which in turn block

113 eukaryotic signaling pathways including the spindle assembly checkpoint, numerous DNA recombination/

114 The spindle assembly checkpoint prevents aneuploidy by ensur

115 The spindle assembly checkpoint prevents separation of siste

116 The mitotic checkpoint (also known as the spindle assembly checkpoint) prevents premature anaphase

117 We have found that the spindle assembly checkpoint protein BubR1 regulates both

118 xhibit normal kinetochore recruitment of the spindle assembly checkpoint protein BubR1 without restor

119 conserved HORMA domain family, including the spindle assembly checkpoint protein MAD2 and the meiotic

120 Both reduplication responses require the spindle assembly checkpoint protein Mad2.

121 Furthermore, we found that inhibiting spindle assembly checkpoint protein Msp1 partly rescued

122 to seven proteins studied here including the spindle assembly checkpoint protein, Bub3.

123 tes the MCC by directly interacting with the spindle assembly checkpoint protein, MAD2.

124 licing mutants is exacerbated by loss of the spindle-assembly checkpoint protein Mad1.

125 ng than by differences in mitotic spindle or spindle assembly checkpoint proteins and that antimitoti

126 Spindle assembly checkpoint proteins have been thought t

127 ers of the mitotic spindle and by recruiting spindle assembly checkpoint proteins Mad1 and Mad2.

128 accharomyces pombe MCC (a complex of mitotic spindle assembly checkpoint proteins Mad2, Mad3 and APC/

129 rence reflects a more permissive role of the spindle assembly checkpoint, rather than solely reflecti

130 tes failed to complete meiosis I because the spindle assembly checkpoint remained active and anaphase

131 during metaphase and for a fully functional spindle assembly checkpoint response.

132 Correspondingly, cyclin B accumulation and spindle assembly checkpoint (SAC) activation were observ

133 r62 depleted cells show spindle instability, spindle assembly checkpoint (SAC) activation, mitotic ar

134 mproperly attached kinetochores activate the spindle assembly checkpoint (SAC) and by an unknown mech

135 resting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Respons

136 The kinase Bub1 functions in the spindle assembly checkpoint (SAC) and in chromosome cong

137 eso1 (eso1-H17) is due to activation of the spindle assembly checkpoint (SAC) and is associated with

138 eveloped surveillance mechanisms such as the spindle assembly checkpoint (SAC) and the DNA damage res

139 The spindle assembly checkpoint (SAC) arrests mitosis until

140 the triple-Glu mutant failed to satisfy the spindle assembly checkpoint (SAC) at metaphase because p

141 The spindle assembly checkpoint (SAC) averts aneuploidy by c

142 The MI arrest is induced by the spindle assembly checkpoint (SAC) because inhibiting the

143 east, both the DNA damage checkpoint and the spindle assembly checkpoint (SAC) block cells prior to a

144 pore complex (NPC) protein implicated in the spindle assembly checkpoint (SAC) by an unknown mechanis

145 Defects in the spindle assembly checkpoint (SAC) can lead to aneuploidy

146 When the spindle assembly checkpoint (SAC) cannot be satisfied, c

147 D family of proteins involved in the mitotic spindle assembly checkpoint (SAC) complex.

148 Here, we report that the conserved spindle assembly checkpoint (SAC) component MDF-1/MAD1 i

149 The Bub1-H2Aph-Sgo1 pathway and spindle assembly checkpoint (SAC) components have been i

150 Here, we report that spindle assembly checkpoint (SAC) components MAD-1, MAD-

151 ences of aneuploidy has relied on perturbing spindle assembly checkpoint (SAC) components, but interp

152 e microtubules (MTs) and the accumulation of spindle assembly checkpoint (SAC) components.

153 The spindle assembly checkpoint (SAC) conveys lack of tensio

154 The spindle assembly checkpoint (SAC) delays anaphase onset

155 The spindle assembly checkpoint (SAC) delays anaphase until

156 The spindle assembly checkpoint (SAC) delays mitotic progres

157 The spindle assembly checkpoint (SAC) delays mitotic progres

158 The Spindle Assembly Checkpoint (SAC) delays the onset of an

159 chore-microtubule (KT-MT) attachment and the spindle assembly checkpoint (SAC) during cell division a

160 The spindle assembly checkpoint (SAC) ensures correct chromo

161 The spindle assembly checkpoint (SAC) ensures faithful chrom

162 In mitosis, the spindle assembly checkpoint (SAC) ensures genome stabili

163 The Spindle Assembly Checkpoint (SAC) ensures genomic stabil

164 In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daug

165 The spindle assembly checkpoint (SAC) ensures that sister ch

166 The spindle assembly checkpoint (SAC) ensures the accurate s

167 The spindle assembly checkpoint (SAC) ensures the faithful s

168 In eukaryotes, the spindle assembly checkpoint (SAC) ensures the fidelity o

169 d by differential display (EDD) in promoting spindle assembly checkpoint (SAC) function.

170 The spindle assembly checkpoint (SAC) functions as a surveil

171 morigenesis model derived from knocking down spindle assembly checkpoint (SAC) genes and preventing a

172 The spindle assembly checkpoint (SAC) in mammals uses cytoso

173 DNA damage activates a pathway involving the spindle assembly checkpoint (SAC) in response to chemica

174 hether APC-deficient cells have a functional spindle assembly checkpoint (SAC) in vivo by examining t

175 indle assembly, chromosome misalignment, and spindle assembly checkpoint (SAC) inactivation.

176 Spindle assembly checkpoint (SAC) is a critical cellular

177 The spindle assembly checkpoint (SAC) is activated at unatta

178 The spindle assembly checkpoint (SAC) is an essential safegu

179 correction, chromosome biorientation and the spindle assembly checkpoint (SAC) is complicated by thei

180 ypersensitive to anoxia, suggesting that the spindle assembly checkpoint (SAC) is compromised.

181 Switch-like activation of the spindle assembly checkpoint (SAC) is critical for accura

182 The spindle assembly checkpoint (SAC) is essential for ensur

183 The spindle assembly checkpoint (SAC) is essential for prope

184 The spindle assembly checkpoint (SAC) is essential to ensure

185 for MCC dissociation from the APC/C once the spindle assembly checkpoint (SAC) is satisfied.

186 The spindle assembly checkpoint (SAC) is the major surveilla

187 Inhibition of the spindle assembly checkpoint (SAC) kinase, Mps1, during M

188 known as the corona, where it scaffolds the spindle assembly checkpoint (SAC) machinery by binding d

189 During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stabi

190 The spindle assembly checkpoint (SAC) maintains genomic stab

191 ginally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast.

192 The spindle assembly checkpoint (SAC) monitors and promotes

193 The spindle assembly checkpoint (SAC) monitors correct attac

194 During mitosis, the spindle assembly checkpoint (SAC) monitors the attachmen

195 amage-induced apoptotic response and mitotic spindle assembly checkpoint (SAC) override in human tumo

196 The spindle assembly checkpoint (SAC) plays a critical role

197 The spindle assembly checkpoint (SAC) prevents anaphase unti

198 ensure accurate chromosome segregation, the spindle assembly checkpoint (SAC) prevents anaphase unti

199 The spindle assembly checkpoint (SAC) prevents aneuploidy by

200 The spindle assembly checkpoint (SAC) prevents chromosome mi

201 The spindle assembly checkpoint (SAC) prevents premature chr

202 , a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produces an inhibitory

203 ole localization of gamma-tubulin and showed spindle assembly checkpoint (SAC) protein Bub3 at the ki

204 Recruitment of spindle assembly checkpoint (SAC) proteins by an unattac

205 atory chromosome passenger complex (CPC) and spindle assembly checkpoint (SAC) proteins in Drosophila

206 itotic roles involving spatial regulation of spindle assembly checkpoint (SAC) proteins.

207 The spindle assembly checkpoint (SAC) relies on the recruitm

208 ~1 h, and this is due to an earlier onset of spindle assembly checkpoint (SAC) satisfaction and APC(C

209 es chromosome attachment to microtubules and spindle assembly checkpoint (SAC) signaling in mitosis.

210 premature mitotic exit is due to defects in spindle assembly checkpoint (SAC) signaling, such that c

211 Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accur

212 ched to the spindle; this is achieved by the Spindle Assembly Checkpoint (SAC) that inhibits the Anap

213 rapeutic agents such as taxanes activate the spindle assembly checkpoint (SAC) to arrest anaphase ons

214 hanosensitive signaling cascade known as the spindle assembly checkpoint (SAC) to detect and signal t

215 have evolved a signaling pathway called the spindle assembly checkpoint (SAC) to increase the fideli

216 mproper kinetochore attachments activate the spindle assembly checkpoint (SAC) to prevent anaphase on

217 APC/C coactivator, Cdc20, is targeted by the spindle assembly checkpoint (SAC) to restrict APC/C acti

218 titioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling

219 K protein kinase) is a core component of the spindle assembly checkpoint (SAC), a genome-surveillance

220 (Mps1) is a central component of the mitotic spindle assembly checkpoint (SAC), a sensing mechanism t

221 , we review the evolutionary dynamics of the spindle assembly checkpoint (SAC), a signaling network t

222 itors or Plk1-null cells is triggered by the spindle assembly checkpoint (SAC), and can be rescued in

223 e I causes acceleration of MI, bypass of the spindle assembly checkpoint (SAC), and loss of interchro

224 Two key components are centrosomes and the spindle assembly checkpoint (SAC), and mutations affecti

225 urea, leading to secondary activation of the spindle assembly checkpoint (SAC), aneuploidy, and letha

226 PCM, form multipolar spindles, activate the spindle assembly checkpoint (SAC), arrest in mitosis, an

227 MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning m

228 ce phenotype that requires components of the spindle assembly checkpoint (SAC), including Bub3 and Ma

229 RIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rat

230 th Aurora inhibitors still have a functional spindle assembly checkpoint (SAC), since the checkpoint

231 is to cell cycle arrest independently of the spindle assembly checkpoint (SAC), suggesting that while

232 descriptions of the G1-S checkpoint and the spindle assembly checkpoint (SAC), the EGF signalling pa

233 ted for degradation by the APC/C, during the spindle assembly checkpoint (SAC), the mitotic checkpoin

234 w chromatid cohesion defects and an impaired spindle assembly checkpoint (SAC), thus undergoing mitot

235 error correction mechanism [1, 2] and by the spindle assembly checkpoint (SAC), which delays cell-cyc

236 egregation during cell division requires the spindle assembly checkpoint (SAC), which detects unattac

237 In the spindle assembly checkpoint (SAC), which enables errorle

238 opolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anapha

239 The spindle assembly checkpoint (SAC), whose reversal upon c

240 es identical mitotic defects that initiate a spindle assembly checkpoint (SAC)-dependent mitotic dela

241 chromosome congression and regulation by the spindle assembly checkpoint (SAC).

242 n at specific times under the control of the spindle assembly checkpoint (SAC).

243 me (APC/C(Cdc20)) by Cdc20 is delayed by the spindle assembly checkpoint (SAC).

244 rometaphase when APC/C is inactivated by the spindle assembly checkpoint (SAC).

245 om mitosis is controlled by silencing of the spindle assembly checkpoint (SAC).

246 degradation and slippage from an unsatisfied spindle assembly checkpoint (SAC).

247 This process is known as the spindle assembly checkpoint (SAC).

248 which maintains chromosome stability at the spindle assembly checkpoint (SAC).

249 tions (K-fibers), a process regulated by the spindle assembly checkpoint (SAC).

250 ity of chromosome segregation depends on the spindle assembly checkpoint (SAC).

251 , sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC).

252 hould be inherently unstable and trigger the spindle assembly checkpoint (SAC).

253 erroneous attachments, and silencing of the spindle assembly checkpoint (SAC).

254 bule attachment as well as activation of the spindle assembly checkpoint (SAC).

255 of chromosome segregation is enhanced by the spindle assembly checkpoint (SAC).

256 s a delay in mitosis that is mediated by the spindle assembly checkpoint (SAC).

257 s in mitotic cells and is a component of the spindle assembly checkpoint (SAC).

258 ression of Polo kinase and components of the spindle assembly checkpoint (SAC).

259 ustered at a monopolar spindle and an active spindle assembly checkpoint (SAC).

260 question from the functional perspectives of spindle assembly checkpoint (SAC).

261 perly attached to the mitotic spindle by the spindle assembly checkpoint (SAC).

262 cipitates with BubR1, a key regulator of the spindle assembly checkpoint (SAC).

263 BubR1 is a key component of the spindle assembly checkpoint (SAC).

264 se data indicate that targeted inhibition of spindle assembly checkpoints (SAC) and chromosomal organ

265 This transition is essential to satisfy the spindle-assembly checkpoint (SAC) and couple MT-generate

266 APC/C(CDC20) activity that is able to escape spindle-assembly checkpoint (SAC)-mediated inhibition, o

267 es to silence the mitotic checkpoint (a.k.a. spindle assembly checkpoint [SAC]).

268 in kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly ove

269 ere impaired, resulting in the activation of spindle assembly checkpoint signaling and, ultimately, e

270 ora B-dependent spindle assembly, but not in spindle assembly checkpoint signaling at unattached kine

271 taining complexes from cells under different spindle assembly checkpoint signaling conditions.

272 port that the nuclear pore complex scaffolds spindle assembly checkpoint signaling in interphase, pro

273 h are involved in chromosome congression and spindle assembly checkpoint signaling.

274 s Bub1 and BubR1 kinetochore recruitment and spindle assembly checkpoint signaling.

275 and stabilizes Bub3, a key player in mitotic spindle assembly checkpoint signaling.

276 t to promote chromosome alignment and robust spindle assembly checkpoint signaling.

277 compromised bipolar attachment and premature spindle assembly checkpoint silencing in the mutant cell

278 Zw10 but not BubR1 from kinetochores during spindle assembly checkpoint silencing.

279 umulation is increased by suppression of the spindle assembly checkpoint, suggesting this effect resu

280 The mitotic (or spindle assembly) checkpoint system delays anaphase unti

281 The mitotic (or spindle assembly) checkpoint system prevents premature s

282 The mitotic (or spindle assembly) checkpoint system prevents premature s

283 spindle 1 kinase (Mps-1) is a kinase of the spindle assembly checkpoint that controls cell division

284 s mechanism of aneuploidy bypasses the known spindle assembly checkpoint that monitors chromosome seg

285 w the APC/C works, with implications for the spindle assembly checkpoint that regulates it.

286 ding cells use a surveillance mechanism, the spindle assembly checkpoint, that monitors the attachmen

287 and p31(comet) collaborate to inactivate the spindle assembly checkpoint through MAD2 conformational

288 s possible that a lowered sensitivity of the spindle assembly checkpoint to certain types of chromoso

289 s to the spindle microtubules and signal the spindle assembly checkpoint to delay mitotic exit until

290 tension at the kinetochore that silences the spindle assembly checkpoint to ensure faithful chromosom

291 Mad2 knockdown released the spindle assembly checkpoint triggered when TOG5-microtub

292 on due to erroneous attachment activates the spindle assembly checkpoint, which corrects the mistakes

293 d the kinetochore microtubules activates the spindle assembly checkpoint, which delays anaphase by bl

294 ssociated with defects in DNA repair and the spindle assembly checkpoint, which in turn can lead to p

295 Mitotic cells arrested by the spindle assembly checkpoint, which inactivates APC/C, of

296 The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-p

297 cell cycle as in Opisthokonts; however, the spindle assembly checkpoint, which targets the APC in Op

298 a a Cdk1/MAPK-dependent stabilization of the spindle assembly checkpoint, which when inhibited leads

299 Mps1 is an upstream component of the spindle assembly checkpoint, which, in human cells, is r

300 on leads to a constitutive activation of the spindle-assembly checkpoint, which therefore causes a la