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2 small (<10 cm) bilaterian with five pairs of spiny anterior arms, an elongated body, and a swollen po
6 Furthermore, thalamic boutons in M1 targeted spiny dendrites exclusively, whereas approximately 9% of
7 matic diameter), possess tortuous, partially spiny dendrites, and are rostrally biased in their posit
8 stratum oriens or pyramidale, have sparsely spiny dendrites, and do not typically express somatostat
9 The majority of samples were identified as Spiny Dogfish (Squalus acanthias), which is critically e
10 In contrast, the potential for overlap of spiny dogfish with prey species was enhanced by warming,
13 induced neurotoxicity in vitro and in medium spiny-like neurons generated from stem cells derived fro
14 s with two gastropod predators-the Caribbean spiny lobster (Panulirus argus) and the grunt black marg
16 we undertake the first analysis of Caribbean spiny lobster diet using a stable isotope approach (carb
17 postlarvae in the Florida Keys and adults of spiny lobster from the Florida Keys and throughout the C
19 duced-pH seawater altered the orientation of spiny lobster pueruli toward chemical cues produced by L
20 different realistic propagation conditions, spiny lobster sounds can be detectable up to several kil
22 l pathway was previously unrecognized in the spiny lobster's diet, and these results are the first em
25 of the sounds from various sizes of European spiny lobsters (Palinurus elephas), recorded between 0.5
26 atogastric nervous system of male and female spiny lobsters (Panulirus interruptus), focused on dynam
27 ges on the survival, growth, and movement of spiny lobsters is growing, the effect on their chemosens
28 ed significantly with body size, the largest spiny lobsters producing SL up to 167 dB re 1 uPa(2).
29 chemical cues from conspecifics are used by spiny lobsters to identify suitable shelter and cues fro
30 dies of hermit crabs, crayfish and lobsters, spiny lobsters, and shrimps are homologous to insect mus
33 p19 in cells from mice and rats, cells from spiny mice and rabbits are highly resistant to H(2)O(2).
34 cies, here we show that several Acomys spp. (spiny mice) and Oryctolagus cuniculus completely regener
39 odel of epimorphic regeneration, the African spiny mouse, to examine cell-based inflammation and test
41 reward circuitry, is comprised of two medium spiny neuron (MSN) subtypes that are classified by their
42 ine action in nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes, those enriched in dopamine
43 tion, RGS9 (through its inhibition of medium spiny neuron D(2)R signaling) suppresses motor dysfuncti
45 M(1) receptors are known to modulate medium spiny neuron responses to corticostriatal glutamatergic
46 annabinoid-dependent inhibition of D1 medium spiny neuron terminals in the lateral hypothalamus that
47 gests that A(2A)R-containing indirect medium spiny neuronal activation reduces ethanol-containing rew
48 ng showed a reduction of the indirect medium spiny neuronal activity in the dorsomedial striatum.
49 - and D2-dopamine receptor-expressing medium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbe
50 etic inhibition of dorsal striatum D1-medium spiny neurons (D1-MSNs) in both juvenile and young-adult
51 mpus (VH) excitatory synapses onto D1 medium spiny neurons (D1-MSNs) in the nucleus accumbens medial
52 Nucleus accumbens dopamine 1 receptor medium spiny neurons (D1-MSNs) play a critical role in the deve
53 , the dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) within this region, which have b
57 e receptor type 2-expressing striatal medium spiny neurons (D2-MSNs) are particularly affected, we hy
58 sing Egr3 in D(2) receptor-containing medium spiny neurons (D2-MSNs) before drug exposure reduces the
59 es of dopamine D2-receptor-expressing medium spiny neurons (D2-MSNs), one of the major cell types in
60 striatal direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) and optically stimulated
62 ed in the direct and indirect pathway medium spiny neurons (dMSNs and iMSNs, respectively), 5-HT6 rec
63 D2Rs from indirect pathway-projecting medium spiny neurons (iMSNs) impairs locomotor activities in a
64 receptor (A(2A)R)-containing indirect medium spiny neurons (iMSNs) in the dorsomedial striatum (DMS)
65 pressed virally in "indirect pathway" medium spiny neurons (iMSNs) in the ventral striatum of D2R kno
66 eceptors (D2Rs) from indirect-pathway medium spiny neurons (iMSNs) is sufficient to impair locomotor
67 estin signaling in 'indirect pathway' medium spiny neurons (iMSNs), because of their central role in
68 ory and inhibitory balance between D1 medium spiny neurons (MSN) and D2 MSN mediates this behavioral
70 atal projection neurons are GABAergic medium spiny neurons (MSN), expressing either the dopamine rece
73 ptional regulation of marker genes of medium spiny neurons (MSNs) allowed best discriminating between
77 nd striatopallidal (indirect pathway) medium spiny neurons (MSNs) and its relevance to repetitive gro
78 increased spontaneous activity of D1 medium spiny neurons (MSNs) and profoundly decreased D2 MSN pro
80 ne subtype 2 (D2) receptor-expressing medium spiny neurons (MSNs) are selectively vulnerable to Tat e
81 of dopamine release and activation of medium spiny neurons (MSNs) are sufficient to drive reinforceme
83 g postsynaptic M1 mAChRs expressed on medium spiny neurons (MSNs) at the origin of the indirect stria
84 e 2 (D2) receptor-expressing striatal medium spiny neurons (MSNs) by breeding transgenic Tat-expressi
85 w they may be specialized to regulate medium spiny neurons (MSNs) by responding to, and altering, exc
88 rdinated activation of two classes of medium spiny neurons (MSNs) expressing D1 or D2 dopamine recept
89 cally involved in addiction, contains medium spiny neurons (MSNs) expressing dopamine D1 or D2 recept
90 -regulation occurs selectively in NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D
91 from an imbalance in the activity of medium spiny neurons (MSNs) from the direct (dMSNs) and indirec
92 involved in mitochondrial dynamics in medium spiny neurons (MSNs) from the nucleus accumbens (NAc), a
93 tural and physiological plasticity of medium spiny neurons (MSNs) have been linked to increased stres
94 dendritic spine analyses on striatal medium spiny neurons (MSNs) in drug-naive rAAV-injected male pa
96 nd dopamine Drd1- and Drd2-expressing medium spiny neurons (MSNs) in NAc core and shell during the in
98 disambiguated synapses onto D1 and D2 medium spiny neurons (MSNs) in the adult male mouse NAc core.
99 whole-cell patch-clamp recordings of medium spiny neurons (MSNs) in the NAc and determined the role
101 n dopamine D1 or D2 subpopulations of medium spiny neurons (MSNs) in the NAc, we found that SIRT1 pro
102 Preclinical evidence suggests that medium spiny neurons (MSNs) in the nucleus accumbens (NAc) unde
103 and morphology of dendritic spines on medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a c
104 ng glutamatergic neurotransmission at medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a r
105 n (t-SP) at glutamatergic synapses on medium spiny neurons (MSNs) in the nucleus accumbens core (NAco
106 w that chemogenetically inhibiting D1 medium spiny neurons (MSNs) in the nucleus accumbens-a populati
109 f GlyRs in accumbal dopamine receptor medium spiny neurons (MSNs) of C57BL/6J mice, analysing mRNA ex
111 timing-dependent plasticity (STDP) in medium spiny neurons (MSNs) of the core nucleus accumbens (NAc)
112 imbalance in the activity of striatal medium spiny neurons (MSNs) of the direct (dMSNs) and indirect
113 induces mushroom spinogenesis in the medium spiny neurons (MSNs) of the dorsal striatum in rats, whi
114 d D2Rs, which are highly expressed in medium spiny neurons (MSNs) of the dorsomedial striatum (DMS),
116 1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the NAc of PV+ interneuron silen
117 1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the nucleus accumbens (NAc) are
118 plasticity at excitatory synapses on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) driv
119 in the reward system, specifically in medium spiny neurons (MSNs) of the nucleus Accumbens (nAc).
121 ecordings in nucleus accumbens (NAcc) medium spiny neurons (MSNs) revealed reciprocal changes in spon
123 or adenosine A2a receptor-expressing medium spiny neurons (MSNs) to determine the role of 2-AG signa
125 daptations in nucleus accumbens (NAc) medium spiny neurons (MSNs) underlie stress-induced depression-
127 during drug seeking in both D1 and D2-medium spiny neurons (MSNs), but increased p-cofilin was observ
129 ure alters dopamine (DA) responses in medium spiny neurons (MSNs), Muntean et al. used a novel cAMP s
130 ty of nucleus accumbens shell (NAcSh) medium spiny neurons (MSNs), one hallmark of cocaine addiction,
131 gically, the complexities of striatal median spiny neurons (MSNs), parvalbumin-positive interneurons
132 ed cell type-specific distinctions in medium spiny neurons (MSNs), the main projection neurons in the
133 a large population of human striatal medium spiny neurons (MSNs), the main target of neurodegenerati
134 gh the functional output of principle medium spiny neurons (MSNs), whereas dysfunctional output of NA
145 synaptic activity of the two types of medium spiny neurons (MSNs): direct and indirect pathway MSNs.
146 label about 1% striatal D1-expressing medium spiny neurons and allow visualization of their dendrites
147 n and Egr-1/Zif268 upregulation in D1-medium spiny neurons and cocaine-induced behaviors, including l
149 fferent aspects of HD pathogenesis in medium-spiny neurons and highlight a complex relationship betwe
151 ons, we show that dCA1 PYRs drive NAc medium spiny neurons and orchestrate their spiking activity usi
152 motor region to the striatum that avoids the spiny neurons and selectively innervates interneurons.
153 model system incorporating GABAergic medium spiny neurons and the HEK293 cells, stably expressing di
155 uced plasticity, and define NAc shell medium spiny neurons as a primary site of persistent AMPA-type
156 unchanged pPKA substrate levels in D1 medium spiny neurons as well as in cholinergic interneurons.
157 Our data show that whether core NAc medium spiny neurons belong to the direct or indirect pathways
158 in striatonigral and striatopallidal medium spiny neurons but not in several interneuron populations
159 ation did not induce excitatory responses in spiny neurons but rather disynaptic inhibitory responses
160 s to basally control PP2A in striatal medium spiny neurons but that dopamine acting via PKA inactivat
161 or optogenetic activation of indirect medium spiny neurons dampened operant conditioned ethanol-conta
162 pression of Auts2 or Caln1 in D2-type medium spiny neurons demonstrated that both genes promote cocai
163 ls and mice expressing mutant Htt, in medium spiny neurons derived from human HD iPSCs and in brain s
164 nce of excitation and inhibition onto medium spiny neurons determines the output of this structure.
165 iors, and new understanding of how D1-medium spiny neurons encode the experience of psychomotor stimu
166 erexpression of FosB in striatonigral medium spiny neurons exacerbated dyskinetic behavior, whereas o
167 on the inputs from nucleus accumbens medium spiny neurons expressing either the D1 or the D2 dopamin
168 delta specifically in the striatum of medium spiny neurons in mice yielded HD-like motor phenotypes,
169 ne-induced changes in excitability of medium spiny neurons in nucleus accumbens and gating the compos
170 of the ability to specifically target medium spiny neurons in the "direct" pathway associated with pr
171 c cortex exerts direct influence over medium spiny neurons in the dorsomedial striatum to represent t
173 ty in dopamine D2 receptor-expressing medium-spiny neurons in the indirect, striatopallidal pathway i
177 dministration specifically in D2-type medium spiny neurons in the nucleus accumbens, an effect seen i
180 that activation of Group I mGluRs in medium spiny neurons induces trafficking of GluA2 from the endo
184 cultured neuroendocrine cells; in D1 medium spiny neurons of NAc slices; and in either male or femal
185 -soluble proteins highly expressed in medium spiny neurons of striatum that are phosphorylated in res
186 sm of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects o
187 te differently synaptic plasticity in medium spiny neurons of the accumbens direct and indirect pathw
188 inking ventral hippocampal outputs to medium spiny neurons of the accumbens may be key sites for the
190 es the density of dendritic spines on medium spiny neurons of the NAc; however, the underlying transc
191 dritic "long thin" spines observed in medium spiny neurons of the nucleus accumbens (NAc) shell of al
194 rmed in NAcS D(1) receptor-expressing medium spiny neurons receiving vmPFC input to examine punishmen
195 ceptor 2a in the striatum, markers of medium spiny neurons signaling via the indirect pathway, associ
196 al excitability, and the inability of medium spiny neurons to regulate activity-induced gene expressi
197 and found that the basal ganglia and medium spiny neurons were most enriched for AN-OCD risk, consis
199 which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain
200 on of synaptic signalling in striatal medium spiny neurons, adult nigral dopaminergic neurons and fro
201 ic synapses on nucleus accumbens core medium spiny neurons, but it is unknown how achieving drug use
202 derived stem cells and differentiated medium spiny neurons, FAN1 knockdown increases CAG repeat expan
204 study specifically Drd1a versus Drd2 medium spiny neurons, revealed that developmental CK1delta OE a
205 nergic interneuron synapses on to DMS medium spiny neurons, suggesting that MOR synaptic plasticity i
206 changes in the morphology of striatal medium spiny neurons, the density of dendritic spines, or the d
207 of gene expression in dorsal striatum medium spiny neurons-unlike most other modules, which showed no
222 ns primarily function to downregulate medium spiny projection neuron (MSN) activity via monosynaptic
223 o optogenetically disconnect the interneuron-spiny projection neuron (SPN) cell circuit on a trial-by
225 hus, PKA-dependent pathways in each class of spiny projection neuron are asynchronously engaged by po
227 dritic spines on the indirect pathway medium spiny projection neuron, indicative of decreased numbers
228 d excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synap
229 re causally attributed to AMPARs in indirect spiny projection neurons (iSPNs) and to excess phasic fi
231 ssion onto this structure's principal medium spiny projection neurons (MSNs), providing a potential m
232 + channel type 2 (Kir2) channels in striatal spiny projection neurons (SPNs) - not NMDA receptors.
233 xcitability and functional synaptic input in spiny projection neurons (SPNs) and fast-spiking interne
234 hway (dopamine D1 receptor-containing; D1R-) spiny projection neurons (SPNs) co-release the opioid ne
235 f cortical excitatory synapses onto striatal spiny projection neurons (SPNs) early in the YAC128 mous
236 with an emphasis on defining whether and how spiny projection neurons (SPNs) engage in the synchroniz
237 onal activation marker in large ensembles of spiny projection neurons (SPNs) expressing dopamine rece
238 ession of IEGs (Arc, Egr2, and Nr4a1) within spiny projection neurons (SPNs) in the dorsal striatum o
239 ity in striatal direct- and indirect-pathway spiny projection neurons (SPNs) is critical for proper m
240 ith unbiased stimulation: striatal D1 and D2 spiny projection neurons (SPNs) receive balanced cortica
243 ssing interneurons than D1- or D2-expressing spiny projection neurons (SPNs), an effect not observed
244 LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopami
245 maintenance of dendritic spines on striatal spiny projection neurons (SPNs), corticostriatal short-t
246 togenesis and are highest in dorsal striatal spiny projection neurons (SPNs), we tested the hypothesi
251 city by electrophysiological recordings from spiny projection neurons and cholinergic interneurons.
252 s strengthened by at least sixfold onto both spiny projection neurons and fast-spiking interneurons i
253 hole-cell patch-clamp recordings of striatal spiny projection neurons and histamine superfusion demon
254 interneurons can regulate the firing of the spiny projection neurons and inhibit the striatal output
256 ostsynaptic AMPA receptor currents in medium spiny projection neurons expressing the D1 dopamine rece
258 e, and provide a teaching signal to striatal spiny projection neurons in the form of dopamine release
259 r levels of dopamine and net PKA activity in spiny projection neurons in the nucleus accumbens of mic
260 ole of the direct (dSPN) and indirect (iSPN) spiny projection neurons in the pDMS in such actions rem
263 ime relationship between dopamine and PKA in spiny projection neurons remains untested in behaving an
264 s greater onto the somata of dorsal striatal spiny projection neurons than onto the somata of dopamin
266 orward mechanism mediating the inhibition of spiny projection neurons through the selective activatio
280 thway: from relay neurons in the thalamus to spiny stellate cells in layer 4 of the primary visual co
281 esponses in the majority of pyramidal cells, spiny stellate cells, and interneurons within the extras
282 gical and functional development of layer IV spiny stellate glutamatergic neurons receiving sensory i
284 The dendritic spine density of mGluR5 KO spiny stellate neurons was significantly higher than in
287 he anesthetized cat to a detailed model of a spiny stellate V1 neuron, we found that output spike tim
288 n and thick stripes, but one type, the giant spiny-stellate neuron, resembling L4B neurons projecting
290 ver, receive a much larger contribution from spiny stellates than previously shown for V2 overall, in
293 mice, PDE10A is equally expressed in medium spiny striatal neurons and in their projections to entop
295 Htt(Q111) mice, of Hdac2 or Hdac3 in medium-spiny striatal neurons that exhibit extensive CAG expans
300 other eutherian mammals, these were usually spiny, which contrasts with their adult, aspiny equivale