ライフサイエンスコーパス: spiny neuron

1 preferentially occurs in the striatal medium spiny neurons.

2 nduced degeneration of striatal medium-sized spiny neurons.

3 d expression of both genes in D2-type medium spiny neurons.

4 transient window of disinhibition for medium spiny neurons.

5 ion in dopamine receptor 1-expressing medium spiny neurons.

6 nd potentiated excitatory synapses on medium spiny neurons.

7 spiking interneurons (FSIs) than onto medium spiny neurons.

8 entiation protocol providing striatal medium spiny neurons.

9 ABAergic inhibition onto direct and indirect spiny neurons.

10 t not D2-dopamine receptor-expressing medium spiny neurons.

11 region, an effect mediated by D2-type medium spiny neurons.

12 in indirect pathway nucleus accumbens medium spiny neurons.

13 and Drd2-expressing (striatopallidal) medium spiny neurons.

14 f excitatory synaptic transmission in medium spiny neurons.

15 eficits in dendritic spine density of medium spiny neurons.

16 costriatal activity in direct pathway medium spiny neurons.

17 ral dopaminergic neurons and striatal medium spiny neurons.

18 the converted neurons were DARPP32(+) medium spiny neurons.

19 iatum and include electrically active medium spiny neurons.

20 d altered the spine morphology of NAc medium spiny neurons.

21 ticostriatal projections and striatal medium spiny neurons.

22 y at the best frequencies in striatal medium spiny neurons.

23 ons occur only in the D1(+) subset of medium spiny neurons.

24 e transcriptomic profiles of striatal medium spiny neurons.

25 wide-range of frequencies in striatal medium spiny neurons.

26 D1 dopamine receptor (Drd1)-enriched medium spiny neurons, accelerates the development of morphine t

27 which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain

28 on of synaptic signalling in striatal medium spiny neurons, adult nigral dopaminergic neurons and fro

29 label about 1% striatal D1-expressing medium spiny neurons and allow visualization of their dendrites

30 n and Egr-1/Zif268 upregulation in D1-medium spiny neurons and cocaine-induced behaviors, including l

31 , affecting most prominently striatal medium spiny neurons and cortical pyramidal neurons.

32 fferent aspects of HD pathogenesis in medium-spiny neurons and highlight a complex relationship betwe

33 ession of identity genes for striatal medium spiny neurons and in dysregulation of cyclic AMP signali

34 in turn lead to hyperexcitability of medium spiny neurons and OCD-like behavior.

35 ons, we show that dCA1 PYRs drive NAc medium spiny neurons and orchestrate their spiking activity usi

36 c) GABAA receptor Cl(-) currents onto medium spiny neurons and pyramidal neurons.

37 motor region to the striatum that avoids the spiny neurons and selectively innervates interneurons.

38 MNI-659 may identify early changes in medium spiny neurons and serve as a marker to predict conversio

39 egulates the excitability of striatal medium spiny neurons and that reduction of Foxp1 correlates wit

40 model system incorporating GABAergic medium spiny neurons and the HEK293 cells, stably expressing di

41 ine neurons as well as D1R-expressing medium spiny neurons and their glutamatergic inputs via NMDARs

42 uding glutamatergic neurons, striatal medium spiny neurons, and GABA interneurons.

43 s in several cortical areas, striatal medium spiny neurons, and hypothalamic neurons.

44 ing two distinct populations of medium-sized spiny neurons, and little is known concerning the cell-t

45 GABAergic medium spiny neurons are the main neuronal population in the st

46 uced plasticity, and define NAc shell medium spiny neurons as a primary site of persistent AMPA-type

47 tified dopamine receptor-1 expressing medium spiny neurons as key mediators of the effects of p11 on

48 unchanged pPKA substrate levels in D1 medium spiny neurons as well as in cholinergic interneurons.

49 nalyses of HEK293 cell innervation by medium spiny neuron axons using immunocytochemistry, activity-d

50 Our data show that whether core NAc medium spiny neurons belong to the direct or indirect pathways

51 We find that corticostriatal and spiny neurons both show precise singing-related firing a

52 in striatonigral and striatopallidal medium spiny neurons but not in several interneuron populations

53 ation did not induce excitatory responses in spiny neurons but rather disynaptic inhibitory responses

54 s to basally control PP2A in striatal medium spiny neurons but that dopamine acting via PKA inactivat

55 ic synapses on nucleus accumbens core medium spiny neurons, but it is unknown how achieving drug use

56 ratio of AMPA to NMDA currents in accumbens spiny neurons compared with yoked saline animals at 2 wk

57 e neurons and nucleus accumbens (NAc) medium spiny neurons, consistent with a presynaptic effect.

58 Tightly clustered small-sized spiny neurons constitute the majority of ITCcs, but they

59 on in D2 dopamine receptor-expressing medium spiny neurons corrected the hyperlocomotor phenotype, wh

60 tion, RGS9 (through its inhibition of medium spiny neuron D(2)R signaling) suppresses motor dysfuncti

61 - and D2-dopamine receptor-expressing medium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbe

62 etic inhibition of dorsal striatum D1-medium spiny neurons (D1-MSNs) in both juvenile and young-adult

63 mpus (VH) excitatory synapses onto D1 medium spiny neurons (D1-MSNs) in the nucleus accumbens medial

64 Nucleus accumbens dopamine 1 receptor medium spiny neurons (D1-MSNs) play a critical role in the deve

65 , the dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) within this region, which have b

66 in D(1) and D(2) receptor-expressing medium spiny neurons (D1/2-MSNs).

67 hed in dopamine receptor 1 containing medium spiny neurons (D1R-MSNs) of the striatum.

68 ion of dopamine 1 receptor-expressing medium spiny neurons (D1R-MSNs).

69 e receptor type 2-expressing striatal medium spiny neurons (D2-MSNs) are particularly affected, we hy

70 sing Egr3 in D(2) receptor-containing medium spiny neurons (D2-MSNs) before drug exposure reduces the

71 es of dopamine D2-receptor-expressing medium spiny neurons (D2-MSNs), one of the major cell types in

72 or optogenetic activation of indirect medium spiny neurons dampened operant conditioned ethanol-conta

73 pression of Auts2 or Caln1 in D2-type medium spiny neurons demonstrated that both genes promote cocai

74 tia nigra pars compacta, yet striatal medium spiny neuron dendritic spine density was largely maintai

75 y, cortical thinning, degeneration of medium spiny neurons, dense mutant Htt inclusion formation, dec

76 ls and mice expressing mutant Htt, in medium spiny neurons derived from human HD iPSCs and in brain s

77 nce of excitation and inhibition onto medium spiny neurons determines the output of this structure.

78 The two populations of medium-sized spiny neurons displayed different patterns of histone mo

79 striatal direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) and optically stimulated

80 NAc direct and indirect pathway medium spiny neurons (dMSNs and iMSNs) can have oppositional co

81 ed in the direct and indirect pathway medium spiny neurons (dMSNs and iMSNs, respectively), 5-HT6 rec

82 dorsomedial relative to dorsolateral medium spiny neurons early in training and population responses

83 iors, and new understanding of how D1-medium spiny neurons encode the experience of psychomotor stimu

84 role of phosphodiesterase 2 (PDE2), a medium spiny neuron-enriched and cGMP-activated PDE, in AMPAR t

85 erexpression of FosB in striatonigral medium spiny neurons exacerbated dyskinetic behavior, whereas o

86 pled receptor that modulates striatal medium spiny neuron excitability.

87 idum (VP) as a site of convergence of medium spiny neurons expressing dopamine (DA) receptor type 1 (

88 on the inputs from nucleus accumbens medium spiny neurons expressing either the D1 or the D2 dopamin

89 derived stem cells and differentiated medium spiny neurons, FAN1 knockdown increases CAG repeat expan

90 ial prefrontal cortex and in striatal medium spiny neurons forming the direct or indirect pathways.

91 of inhibitory, indirect pathway medium-sized spiny neuron (iMSN) NMDA-Rs has been used to address the

92 D2Rs from indirect pathway-projecting medium spiny neurons (iMSNs) impairs locomotor activities in a

93 receptor (A(2A)R)-containing indirect medium spiny neurons (iMSNs) in the dorsomedial striatum (DMS)

94 pressed virally in "indirect pathway" medium spiny neurons (iMSNs) in the ventral striatum of D2R kno

95 eceptors (D2Rs) from indirect-pathway medium spiny neurons (iMSNs) is sufficient to impair locomotor

96 estin signaling in 'indirect pathway' medium spiny neurons (iMSNs), because of their central role in

97 c synaptic transmission onto striatal medium spiny neurons in a manner reminiscent of endogenous mesD

98 d expression of DARPP-32 in accumbens medium spiny neurons in a pattern indicative of reduced transmi

99 Qualitatively, aspiny and spiny neurons in both species appeared morphologically s

100 delta specifically in the striatum of medium spiny neurons in mice yielded HD-like motor phenotypes,

101 eases the density of stubby spines on medium spiny neurons in NAc, and that maintaining this increase

102 mbic DA neurons, eliciting EPSCs onto medium spiny neurons in NAc.

103 ne-induced changes in excitability of medium spiny neurons in nucleus accumbens and gating the compos

104 of the ability to specifically target medium spiny neurons in the "direct" pathway associated with pr

105 and increased spine head diameter in medium spiny neurons in the accumbens core (NAcore).

106 ses a specific loss of HFS-LTP in the medium spiny neurons in the direct pathway without affecting LT

107 cortex, terminates on direct pathway medium spiny neurons in the dorsolateral striatum, and is stren

108 c cortex exerts direct influence over medium spiny neurons in the dorsomedial striatum to represent t

109 idal neurons and, to a lesser extent, medium spiny neurons in the dorsomedial striatum.

110 ty in dopamine D2 receptor-expressing medium-spiny neurons in the indirect, striatopallidal pathway i

111 nhanced the intrinsic excitability of medium spiny neurons in the NAc core and reduced the function a

112 FC inputs to D(1) receptor-expressing medium spiny neurons in the NAcS.

113 - and dopamine D2 receptor-expressing medium spiny neurons in the nucleus accumbens shell.

114 Furthermore, medium spiny neurons in the nucleus accumbens, an area implicat

115 dministration specifically in D2-type medium spiny neurons in the nucleus accumbens, an effect seen i

116 ediated excitation of D(1)-expressing medium spiny neurons in the nucleus accumbens.

117 als modulated time-related ramping of medium spiny neurons in the striatum.

118 modulates the synaptic connections of medium spiny neurons in the striatum.

119 exhibit several abnormalities in NAc medium spiny neurons, including reduced presynaptic function an

120 that activation of Group I mGluRs in medium spiny neurons induces trafficking of GluA2 from the endo

121 ed in the knock-in mice by changes in medium spiny neuron intrinsic excitability and nucleus accumben

122 bindin is preferentially expressed in medium spiny neurons involved in the indirect pathway.

123 Medium spiny neurons mature electrophysiologically following as

124 rly in dopamine receptor-1 expressing medium spiny neurons, may underlie pathophysiological mechanism

125 ase (HD) is characterized by striatal medium spiny neuron (MSN) dysfunction, but the underlying mecha

126 accumulation of DeltaFosB in the two medium spiny neuron (MSN) subtypes in this region.

127 reward circuitry, is comprised of two medium spiny neuron (MSN) subtypes that are classified by their

128 ine action in nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes, those enriched in dopamine

129 europlasticity adaptations in the two medium spiny neuron (MSN) subtypes, those enriched in dopamine

130 regulation in nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes, those enriched in dopamine

131 ltaFosB induction in the two striatal medium spiny neuron (MSN) subtypes.

132 type within the NAc is the GABAergic medium spiny neuron (MSN), with two major subpopulations define

133 ory and inhibitory balance between D1 medium spiny neurons (MSN) and D2 MSN mediates this behavioral

134 The medium spiny neurons (MSN) that give rise to these pathways are

135 atal projection neurons are GABAergic medium spiny neurons (MSN), expressing either the dopamine rece

136 strength onto nucleus accumbens (NAc) medium spiny neurons (MSN).

137 al recordings of striatal projection "medium spiny neurons" (MSN).

138 ine D2 receptor (D2R) in the striatal medium spiny neurons (MSNs) (iMSN-D2RKO).

139 ptional regulation of marker genes of medium spiny neurons (MSNs) allowed best discriminating between

140 ignals converging onto striatal medium-sized spiny neurons (MSNs) and activate intracellular events i

141 rinsic excitability of striatal medium-sized spiny neurons (MSNs) and anxiety levels.

142 Finally, since both D2-medium spiny neurons (MSNs) and D2-expressing choline acetyltra

143 We found that DMS medium spiny neurons (MSNs) and fast-spiking interneurons (FSIs

144 GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses

145 nd striatopallidal (indirect pathway) medium spiny neurons (MSNs) and its relevance to repetitive gro

146 increased spontaneous activity of D1 medium spiny neurons (MSNs) and profoundly decreased D2 MSN pro

147 striatonigral and striatopallidal) of medium spiny neurons (MSNs) and synapses belonging to two neura

148 Medium spiny neurons (MSNs) are a key population in the basal g

149 Medium spiny neurons (MSNs) are a major target of dopamine in t

150 ne subtype 2 (D2) receptor-expressing medium spiny neurons (MSNs) are selectively vulnerable to Tat e

151 Medium spiny neurons (MSNs) are striatal output neurons forming

152 of dopamine release and activation of medium spiny neurons (MSNs) are sufficient to drive reinforceme

153 Gabaergic striatal medium spiny neurons (MSNs) are the only output of this pivotal

154 GABAergic medium-sized spiny neurons (MSNs) are the principal projection neuron

155 onigral (SN) and striatopallidal (SP) medium spiny neurons (MSNs) as playing a key role.

156 g postsynaptic M1 mAChRs expressed on medium spiny neurons (MSNs) at the origin of the indirect stria

157 e 2 (D2) receptor-expressing striatal medium spiny neurons (MSNs) by breeding transgenic Tat-expressi

158 w they may be specialized to regulate medium spiny neurons (MSNs) by responding to, and altering, exc

159 Medium spiny neurons (MSNs) comprise over 90% of cells in the s

160 mice, striatal D1 receptor-expressing medium spiny neurons (MSNs) directly projecting to the substant

161 ntribution to activity in networks of medium spiny neurons (MSNs) during behavior.

162 rdinated activation of two classes of medium spiny neurons (MSNs) expressing D1 or D2 dopamine recept

163 cally involved in addiction, contains medium spiny neurons (MSNs) expressing dopamine D1 or D2 recept

164 -regulation occurs selectively in NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D

165 Striatal medium spiny neurons (MSNs) form inhibitory synapses on neighbo

166 from an imbalance in the activity of medium spiny neurons (MSNs) from the direct (dMSNs) and indirec

167 involved in mitochondrial dynamics in medium spiny neurons (MSNs) from the nucleus accumbens (NAc), a

168 dent dendritic spine loss in striatal medium spiny neurons (MSNs) from YAC128 transgenic HD mice.

169 tural and physiological plasticity of medium spiny neurons (MSNs) have been linked to increased stres

170 dendritic spine analyses on striatal medium spiny neurons (MSNs) in drug-naive rAAV-injected male pa

171 Cell sorting of medium spiny neurons (MSNs) in indirect MSNs and direct MSNs in

172 nd dopamine Drd1- and Drd2-expressing medium spiny neurons (MSNs) in NAc core and shell during the in

173 efrontal cortex (PFC) onto identified medium spiny neurons (MSNs) in the adult accumbens core.

174 disambiguated synapses onto D1 and D2 medium spiny neurons (MSNs) in the adult male mouse NAc core.

175 Balanced activity of medium spiny neurons (MSNs) in the direct and the indirect path

176 whole-cell patch-clamp recordings of medium spiny neurons (MSNs) in the NAc and determined the role

177 onto D(1) receptor-expressing [D1(+)] medium spiny neurons (MSNs) in the NAc core.

178 n dopamine D1 or D2 subpopulations of medium spiny neurons (MSNs) in the NAc, we found that SIRT1 pro

179 Preclinical evidence suggests that medium spiny neurons (MSNs) in the nucleus accumbens (NAc) unde

180 and morphology of dendritic spines on medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a c

181 ng glutamatergic neurotransmission at medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a r

182 ructural and functional properties of medium spiny neurons (MSNs) in the nucleus accumbens (NAc).

183 n (t-SP) at glutamatergic synapses on medium spiny neurons (MSNs) in the nucleus accumbens core (NAco

184 w that chemogenetically inhibiting D1 medium spiny neurons (MSNs) in the nucleus accumbens-a populati

185 c synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress resp

186 riatum, colocalized with the striatal medium spiny neurons (MSNs) marker, D1-receptor associated sign

187 Striatal medium spiny neurons (MSNs) mediate many of the physiological e

188 Medium spiny neurons (MSNs) mediate NAc output by projecting to

189 logical alterations in striatal medium-sized spiny neurons (MSNs) of 2 HD mouse models.

190 f GlyRs in accumbal dopamine receptor medium spiny neurons (MSNs) of C57BL/6J mice, analysing mRNA ex

191 nd functional synaptic alterations in medium spiny neurons (MSNs) of nucleus accumbens (NAc).

192 timing-dependent plasticity (STDP) in medium spiny neurons (MSNs) of the core nucleus accumbens (NAc)

193 imbalance in the activity of striatal medium spiny neurons (MSNs) of the direct (dMSNs) and indirect

194 induces mushroom spinogenesis in the medium spiny neurons (MSNs) of the dorsal striatum in rats, whi

195 d D2Rs, which are highly expressed in medium spiny neurons (MSNs) of the dorsomedial striatum (DMS),

196 Ac and their modulation by ethanol in medium spiny neurons (MSNs) of the mouse nAc.

197 1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the NAc of PV+ interneuron silen

198 1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the nucleus accumbens (NAc) are

199 plasticity at excitatory synapses on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) driv

200 Structural alterations on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) have

201 ("incubated rats") exhibit changes in medium spiny neurons (MSNs) of the nucleus accumbens (NAc) that

202 erations in the synaptic structure of medium spiny neurons (MSNs) of the nucleus accumbens (NAc), a p

203 in the reward system, specifically in medium spiny neurons (MSNs) of the nucleus Accumbens (nAc).

204 nal-regulated kinase (ERK) pathway in medium spiny neurons (MSNs) of the striatum controls psychostim

205 se brain neurons, most prominently in medium spiny neurons (MSNs) of the striatum.

206 ifications in nucleus accumbens (NAc) medium spiny neurons (MSNs) play a key role in adaptive and pat

207 Subtypes of nucleus accumbens medium spiny neurons (MSNs) promote dichotomous outcomes in mot

208 ecordings in nucleus accumbens (NAcc) medium spiny neurons (MSNs) revealed reciprocal changes in spon

209 activity of two subpopulations of NAc medium spiny neurons (MSNs) that are defined by their predomina

210 In transgenic mice, medium spiny neurons (MSNs) that exhibited perinuclear inclusio

211 The majority of DMS cells are medium spiny neurons (MSNs) that express dopamine D1 receptors

212 The DMS is comprised of medium spiny neurons (MSNs) that project directly (dMSNs) or in

213 NAc core of rats modulates GABAergic medium spiny neurons (MSNs) through presynaptic-glutamatergic a

214 or adenosine A2a receptor-expressing medium spiny neurons (MSNs) to determine the role of 2-AG signa

215 We found that striatal medium spiny neurons (MSNs) triggered astrocyte signaling via g

216 daptations in nucleus accumbens (NAc) medium spiny neurons (MSNs) underlie stress-induced depression-

217 s and paired recordings from CHIs and medium spiny neurons (MSNs) virally overexpressing G-protein-ac

218 ighly expressed PDE in striatal medium-sized spiny neurons (MSNs) with low micromolar affinity for bo

219 Individual medium spiny neurons (MSNs) within the VS serve as a site of co

220 ighly enriched population of striatal medium spiny neurons (MSNs), a neuronal subpopulation that has

221 NAc, dendritic spine formation on NAc medium spiny neurons (MSNs), and locomotor sensitization to coc

222 during drug seeking in both D1 and D2-medium spiny neurons (MSNs), but increased p-cofilin was observ

223 The NAc consists largely of medium spiny neurons (MSNs), distinguished by their predominant

224 te gyrus granule cells or in striatal medium spiny neurons (MSNs), indicating predominant expression

225 ure alters dopamine (DA) responses in medium spiny neurons (MSNs), Muntean et al. used a novel cAMP s

226 ty of nucleus accumbens shell (NAcSh) medium spiny neurons (MSNs), one hallmark of cocaine addiction,

227 gically, the complexities of striatal median spiny neurons (MSNs), parvalbumin-positive interneurons

228 ed cell type-specific distinctions in medium spiny neurons (MSNs), the main projection neurons in the

229 a large population of human striatal medium spiny neurons (MSNs), the main target of neurodegenerati

230 eases disynaptic GABAergic input onto medium spiny neurons (MSNs), the major output neurons of the st

231 gh the functional output of principle medium spiny neurons (MSNs), whereas dysfunctional output of NA

232 dopamine-receptor-expressing striatal medium spiny neurons (MSNs), which are interspersed and electri

233 enhanced in a subpopulation of medium-sized spiny neurons (MSNs), which could dampen striatal output

234 esulting from dysfunction of striatal medium spiny neurons (MSNs), which form the main output project

235 for these neuromodulators in striatal medium spiny neurons (MSNs), which play important roles in plas

236 use a computational network model of medium spiny neurons (MSNs)-fast-spiking interneurons (FSIs), b

237 ing ACC inputs to individual striatal medium spiny neurons (MSNs).

238 ward region composed predominantly of medium spiny neurons (MSNs).

239 behaviors partially by activating NAc medium spiny neurons (MSNs).

240 in dendritic spine morphology of NAc medium spiny neurons (MSNs).

241 itic spine density in striatopallidal medium spiny neurons (MSNs).

242 n each of the two distinct classes of medium spiny neurons (MSNs).

243 pamine receptor-1 (D1) containing NAc medium spiny neurons (MSNs).

244 te striatal glutamatergic inputs onto medium spiny neurons (MSNs).

245 pressed potassium channels (GIRK2) in medium spiny neurons (MSNs).

246 g-dependent long-term potentiation in medium spiny neurons (MSNs).

247 either D1- or D2-expressing striatal medium spiny neurons (MSNs).

248 G, is predominantly composed of medium-sized spiny neurons (MSNs).

249 tion of neurons analogous to striatal medium spiny neurons (MSNs).

250 ectively expressed in striatopallidal medium spiny neurons (MSNs).

251 t to the NAc, directly regulating NAc medium spiny neurons (MSNs).

252 the main neurons of the striatum, the medium spiny neurons (MSNs).

253 c currents (EPSCs) in NAcSh principal medium spiny neurons (MSNs).

254 D2 dopamine receptor (D2R)-expressing medium spiny neurons (MSNs).

255 synaptic activity of the two types of medium spiny neurons (MSNs): direct and indirect pathway MSNs.

256 ostsynaptic currents was depressed in medium spiny neurons of ethanol drinking mice.

257 s as well as en masse contractions in medium spiny neurons of HD mouse striatum.

258 cultured neuroendocrine cells; in D1 medium spiny neurons of NAc slices; and in either male or femal

259 -soluble proteins highly expressed in medium spiny neurons of striatum that are phosphorylated in res

260 sm of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects o

261 te differently synaptic plasticity in medium spiny neurons of the accumbens direct and indirect pathw

262 inking ventral hippocampal outputs to medium spiny neurons of the accumbens may be key sites for the

263 By acting in the striatal medium spiny neurons of the direct pathway, NF1 regulates opioi

264 es the density of dendritic spines on medium spiny neurons of the NAc; however, the underlying transc

265 dritic "long thin" spines observed in medium spiny neurons of the nucleus accumbens (NAc) shell of al

266 display a loss of dendritic spines in medium spiny neurons of the nucleus accumbens (Nacc) shell, acc

267 d the associated hyperexcitability of medium spiny neurons of the nucleus accumbens.

268 By contrast, the medium spiny neurons of the striatum and the catecholaminergic

269 terneurons, pyramidal neurons and the medium spiny neurons of the striatum, implicating cortical and

270 hate and is highly expressed in medium-sized spiny neurons of the striatum, making it an attractive t

271 , when expressed in mice in GABAergic medium spiny neurons of the striatum, the beta-arrestin-biased

272 NMDARs) in the selectively vulnerable medium spiny neurons of the striatum.

273 le-cell voltage clamp recordings from medium spiny neurons of the striatum.

274 -specific enrichments in the D1(+) and D2(+) spiny neurons of the striatum.

275 trate that altering cAMP signaling in medium spiny neurons of the ventral striatum can effectively mo

276 In striatal medium spiny neurons, PDE10A is localized at the plasma membran

277 amically modulated by uncertainty across the spiny neuron population, allowing the system to self-tun

278 rmed in NAcS D(1) receptor-expressing medium spiny neurons receiving vmPFC input to examine punishmen

279 naling in SNc DA neurons and striatal medium spiny neurons, respectively.

280 M(1) receptors are known to modulate medium spiny neuron responses to corticostriatal glutamatergic

281 study specifically Drd1a versus Drd2 medium spiny neurons, revealed that developmental CK1delta OE a

282 ceptor 2a in the striatum, markers of medium spiny neurons signaling via the indirect pathway, associ

283 To identify NAc medium spiny neuron subtypes, we used mice expressing tdTomato

284 nergic interneuron synapses on to DMS medium spiny neurons, suggesting that MOR synaptic plasticity i

285 ride channel into rat dorsal striatal medium spiny neurons, targets of strong dopamine innervation, t

286 annabinoid-dependent inhibition of D1 medium spiny neuron terminals in the lateral hypothalamus that

287 produced strong GABAergic inhibition in all spiny neurons tested.

288 10A) is an enzyme present in striatal medium spiny neurons that degrades the intracellular second mes

289 changes in the morphology of striatal medium spiny neurons, the density of dendritic spines, or the d

290 ral model, TANs modulate the excitability of spiny neurons, their population response to reinforcemen

291 recordings were performed in NAc core medium spiny neurons to assess the contribution of CP-AMPAR tra

292 al excitability, and the inability of medium spiny neurons to regulate activity-induced gene expressi

293 of gene expression in dorsal striatum medium spiny neurons-unlike most other modules, which showed no

294 e thalamus and D2-receptor-expressing medium spiny neurons via synaptic insertion of GluA2-lacking AM

295 Although the morphology of spiny neurons was diverse, with the presence of extraver

296 and found that the basal ganglia and medium spiny neurons were most enriched for AN-OCD risk, consis

297 tant huntingtin primarily in striatal medium spiny neurons, which highly express phosphodiesterase 10

298 RIIbeta reexpression in all striatal medium spiny neurons with Darpp32-Cre corrected the hyperlocomo

299 n pyramidal neurons of layer V and in medium spiny neurons within striosomes.

300 lectively recruits feedforward inhibition of spiny neurons without any accompanying excitation.