ライフサイエンスコーパス: spiral ganglion

1 ocalizes to inner ear sensory hair cells and spiral ganglion.

2 ibular end organs as well as in cells of the spiral ganglion.

3 n hair cells and postnatal expression in the spiral ganglion.

4 that compose approximately 95% of the adult spiral ganglion.

5 air cells and the first order neurons of the spiral ganglion.

6 firing properties in neurons throughout the spiral ganglion.

7 on of the organ of Corti and its innervating spiral ganglion.

8 ou3f4-expressing cells around and within the spiral ganglion.

9 ar and cochlear sensory epithelia and to the spiral ganglions.

10 through anatomically distinct populations of spiral ganglion afferent neurons.

11 system, a basic organizing principle of the spiral ganglion afferents is their extensive electrophys

12 t on their postsynaptic targets, the type II spiral ganglion afferents.

13 may set the "address" of neurons within the spiral ganglion, allowing them to elaborate the appropri

14 uitment into both the sensory epithelium and spiral ganglion and also resulted in diminished survival

15 iring activity has been observed in immature spiral ganglion and brain-stem neurons and is likely to

16 fluorescent protein provided observation of spiral ganglion and cochlear nucleus neurons to facilita

17 of the dysfunctional Kcnq4_v3 variant in the spiral ganglion and inner hair cells in the basal hook r

18 tly complementary expression patterns in the spiral ganglion and its nearby region, the spiral limbus

19 tory neurons, including the formation of the spiral ganglion and peripheral and central processes tha

20 f Tg-mtTFB1 mice implicated apoptosis in the spiral ganglion and stria vascularis because of mitochon

21 By P10, these fibers had reached the spiral ganglion and were projecting toward the organ of

22 cellular proteins within the organ of Corti, spiral ganglion, and stria vascularis, which are known t

23 is sufficient to attract leukocytes into the spiral ganglion, and that fractalkine signaling plays a

24 the cochlear epithelium and the main body of spiral ganglion, and the neurites of mispositioned SGNs

25 he auditory vascular-neuronal complex in the spiral ganglion are not yet known.

26 ditory maturation, and further implicate the spiral ganglion as a potential controlling centre in thi

27 andardized locations along the length of the spiral ganglion, as determined from serial reconstructio

28 his principle also applies to neurons of the spiral ganglion, as evidenced by distinctly different fi

29 dditional dimension of complexity within the spiral ganglion beyond that currently categorized.

30 ive degeneration includes hair cells and the spiral ganglion, but the brain itself is spared despite

31 ed macrophages were also observed within the spiral ganglion, but their numbers remained elevated for

32 bular and cochlear sensory epithelia and the spiral ganglion - by measuring electrophysiological prop

33 Spiral ganglion cell (SGC) degeneration was prevented du

34 The spatial distribution of spiral ganglion cell loss correlated with the pattern of

35 s unclear how these topologic differences in spiral ganglion cell morphology and density emerge durin

36 ans of a cochlear implant requires a healthy spiral ganglion cell population.

37 Spiral ganglion cell somata were also labeled as early a

38 The difference in symmetry of spiral ganglion cell survival between the two groups was

39 In contrast, spiral ganglion cell survival was bilaterally symmetric

40 In the absence of chronic stimulation, spiral ganglion cell survival was relatively symmetric i

41 f unilateral chronic electrical stimulation, spiral ganglion cell survival was significantly greater

42 Electrical stimulation (ES) of spiral ganglion cells (SGCs) has been shown to enhance t

43 The remaining spiral ganglion cells (type IIs) are unmyelinated and co

44 Spiral ganglion cells acquire action potential-generatin

45 Our injections also transduced 10% of spiral ganglion cells and a much larger fraction of thei

46 gous knockout mice were examined for loss of spiral ganglion cells and eighth nerve fibers.

47 crodissected immature (postnatal days 10-13) spiral ganglion cells and outer hair cells but not inner

48 stane was increased in the stria vascularis, spiral ganglion cells and the organ of Corti.

49 ividuals, our findings suggest that cochlear spiral ganglion cells are sensitive to top-down attentio

50 (postnatal days 10-13) inner hair cells and spiral ganglion cells but not outer hair cells.

51 In the cochlea, nNOS was identified in spiral ganglion cells by using nicotinamide adenine dinu

52 In mammals, the size and number of spiral ganglion cells can vary significantly along the l

53 knockout mice also had a significant loss of spiral ganglion cells compared with 2-month-old wild-typ

54 The onset of diaphorase expression in the spiral ganglion cells corresponds to a critical period o

55 t postnatal week, the total number of gerbil spiral ganglion cells decreased significantly by 27%, wi

56 The extent to which spiral ganglion cells forming the human auditory nerve a

57 ls in both sexes as well as small savings of spiral ganglion cells in females and inner hair cells in

58 Nerve fibers from spiral ganglion cells in the middle turn extended to inn

59 he electrical responsiveness of BDNF-treated spiral ganglion cells is preserved during this period as

60 strikingly, significant degeneration of the spiral ganglion cells of the auditory nerve.

61 hat mGluR7 is expressed in hair cells and in spiral ganglion cells of the inner ear.

62 D4 was detected in spiral ganglion cells only.

63 in-3 (NT-3) or its receptor, TrkC, lose many spiral ganglion cells predominantly in the basal turn of

64 ations of cells within the organ of Corti or spiral ganglion cells rather than a mixed population of

65 We have shown that cochlear spiral ganglion cells secrete OPG at high levels and lac

66 ssed survival of primary auditory afferents (spiral ganglion cells) in systemically deafened guinea p

67 zable organ of Corti, presented >90% loss of spiral ganglion cells, and displayed marked structural a

68 esholds and the loss of outer hair cells and spiral ganglion cells, but not with the loss of inner ha

69 cilia and a base-apex loss of hair cells and spiral ganglion cells, were consistent with the observed

70 ubsequent degeneration of the hair cells and spiral ganglion cells.

71 expression in cochlear outer hair cells and spiral ganglion cells.

72 In whole-cell recordings from rat spiral ganglion cultures, the purinergic agonist 2',3'-O

73 during early development and in cells of the spiral ganglion during early development and adulthood.

74 that neurons with different positions in the spiral ganglion employ different guidance mechanisms, wi

75 various functional domains (organ of Corti, spiral ganglion, etc.) by LCM.

76 To understand the determinants of spiral ganglion function, we characterized the NT-3 conc

77 ervation of highly derived structures of the spiral ganglion in yangochiropteran bats: a trans-otic g

78 e type II proximal, radial process, near the spiral ganglion, in agreement with the high voltage thre

79 The spiral ganglion is a compelling model system to examine

80 viour depends on the inner ear, of which the spiral ganglion is an essential structure.

81 PLZF immunoreactivity is present in the spiral ganglion, lateral wall of the cochlea, and organ

82 thods to co-culture neural stem cell-derived spiral ganglion-like neurons (ScNs) and mouse auditory c

83 ocalize with the Schwann cell marker Krox20, spiral ganglion marker NF200, nor glial fibrillary acidi

84 ra differentiated from Yinpterochiroptera in spiral ganglion neuroanatomy.

85 and numbers were normal, the inner hair cell-spiral ganglion neuron (IHC-SGN) synapse revealed abnorm

86 Dissociated spiral ganglion neuron (SGN) cell cultures and organ of

87 Spiral ganglion neuron (SGN) degeneration is a candidate

88 elination patterns at the heminode of type I spiral ganglion neuron (SGN) peripheral terminals, sugge

89 analog), and membrane depolarization promote spiral ganglion neuron (SGN) survival in vitro in an add

90 the ability to seal the reticular lamina and spiral ganglion neuron counts are normal, a key requirem

91 n experiments to examine the role of Sox2 in spiral ganglion neuron formation.

92 We propose that type I spiral ganglion neuron functional maturation depends on

93 Prph((-/-)) mice lacked type II spiral ganglion neuron innervation of the outer hair cel

94 Spiral ganglion neuron responses to depolarizing current

95 membrane level were investigated on isolated spiral ganglion neuron somata from guinea-pigs by whole-

96 ons between BDNF and NT-3 may be crucial for spiral ganglion neuron survival during the final stages

97 ed two broad electrophysiological classes of spiral ganglion neuron that differ in their rate of acco

98 -clamp recordings were made from mouse basal spiral ganglion neurons (postnatal day 5) exposed to dif

99 ir cells (IHC), auditory nerve fibers (ANF), spiral ganglion neurons (SGN) and vestibular hair cells

100 In particular, we found that fibers of spiral ganglion neurons (SGN) close to the organ of Cort

101 tion is transmitted by different subtypes of spiral ganglion neurons (SGN) from the ear to the brain.

102 broblast growth factor 8 (FGF8) in mammalian spiral ganglion neurons (SGN) neurite outgrowth has not

103 eripherin expression is a marker for type II spiral ganglion neurons (SGN) that innervate the cochlea

104 ochlea to the brain by different subtypes of spiral ganglion neurons (SGN), which show varying degree

105 Optogenetic stimulation of spiral ganglion neurons (SGNs) activated the auditory pa

106 depletion causes loss of vascular volume and spiral ganglion neurons (SGNs) and adversely affects hea

107 romoting stimulus for cultured postnatal rat spiral ganglion neurons (SGNs) and that depolarization p

108 f espins to a large proportion of rat type I spiral ganglion neurons (SGNs) and their projections to

109 In addition to HCs, spiral ganglion neurons (SGNs) are also impacted in a la

110 T Physiologically distinct classes of type I spiral ganglion neurons (SGNs) are necessary to encode s

111 Spiral ganglion neurons (SGNs) are postsynaptic to hair

112 Spiral ganglion neurons (SGNs) are primary sensory affer

113 Type II spiral ganglion neurons (SGNs) are small caliber, unmyel

114 The mammalian spiral ganglion neurons (SGNs) are specialzed bipolar ne

115 development, primary auditory neurons named spiral ganglion neurons (SGNs) are surrounded by otic me

116 vely achieved by functionally diverse type I spiral ganglion neurons (SGNs) at each tonotopic positio

117 (BzATP) activated desensitizing currents in spiral ganglion neurons (SGNs) but non-desensitizing cur

118 Spiral ganglion neurons (SGNs) carry sound information f

119 ng loss have long suggested that survival of spiral ganglion neurons (SGNs) depends on trophic suppor

120 Mammalian cochlear spiral ganglion neurons (SGNs) encode sound with microse

121 development of periphery auditory circuits, spiral ganglion neurons (SGNs) extend their neurites to

122 Peripheral axons from auditory spiral ganglion neurons (SGNs) form an elaborate series

123 oss, involves degeneration of hair cells and spiral ganglion neurons (SGNs) from basal to apical coch

124 synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea.

125 s between inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs) in the inner ear are dama

126 and neuromodulators, has been identified on spiral ganglion neurons (SGNs) in the inner ear; however

127 s known about the fate of efferent fibers or spiral ganglion neurons (SGNs) in this model.

128 he exception of humans, the somata of type I spiral ganglion neurons (SGNs) of most mammalian species

129 Degeneration of the spiral ganglion neurons (SGNs) of the auditory nerve occ

130 the development of the prosensory domain and spiral ganglion neurons (SGNs) of the mouse cochlea duri

131 sound damages the postsynaptic terminals of spiral ganglion neurons (SGNs) on cochlear inner hair ce

132 Spiral ganglion neurons (SGNs) play a key role in hearin

133 In the auditory system, type I spiral ganglion neurons (SGNs) project their peripheral

134 Spiral ganglion neurons (SGNs) receive input from cochle

135 Spiral ganglion neurons (SGNs) relay acoustic code from

136 Spiral ganglion neurons (SGNs) require both pre- and pos

137 synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) that carry acoustic infor

138 itory system encodes sounds with subtypes of spiral ganglion neurons (SGNs) that differ in sound leve

139 ls are relayed from the ear to the brain via spiral ganglion neurons (SGNs) that receive auditory inf

140 For sounds of a given frequency, spiral ganglion neurons (SGNs) with different thresholds

141 c) contributes to the proper organization of spiral ganglion neurons (SGNs) within the Rosenthal's ca

142 Such injury can also lead to degeneration of spiral ganglion neurons (SGNs), but this occurs over a p

143 complementary coding by functionally diverse spiral ganglion neurons (SGNs), each changing activity o

144 lateral olivocochlear (LOC) neurons, target spiral ganglion neurons (SGNs), the primary sensory neur

145 Loss of spiral ganglion neurons (SGNs), the primary sensory rela

146 eloping murine cochlea, where two classes of spiral ganglion neurons (SGNs), type I and type II, navi

147 We found that NRG1 is expressed by spiral ganglion neurons (SGNs), whereas erbB2 and erbB3

148 the radiation beam was directed towards the spiral ganglion neurons (SGNs), whereas little responses

149 t innervation of the cochlea is comprised of spiral ganglion neurons (SGNs), which are characterized

150 nd mechanically to sound waves, and afferent spiral ganglion neurons (SGNs), which respond to glutama

151 y cells in the cochlea, i.e., hair cells and spiral ganglion neurons (SGNs), with a focus on their to

152 bursts of action potentials in postsynaptic spiral ganglion neurons (SGNs).

153 stroy hair cells, the sole afferent input to spiral ganglion neurons (SGNs).

154 napses formed by inner hair cells (IHCs) and spiral ganglion neurons (SGNs).

155 es of sensory neurons, called Ia, Ib, and Ic spiral ganglion neurons (SGNs).

156 through glutamatergic synapses onto type II spiral ganglion neurons (SGNs).

157 IHCs), and was lacking from the postsynaptic spiral ganglion neurons (SGNs).

158 ed into a mini-burst of action potentials in spiral ganglion neurons (SGNs).

159 eripheral auditory fibers (PAFs) and loss of spiral ganglion neurons (SGNs).

160 cells directly in the sensory epithelium or spiral ganglion neurons (SGNs).

161 mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs).

162 -profoundly deaf by electrically stimulating spiral ganglion neurons (SGNs).

163 transmit auditory information faithfully to spiral ganglion neurons (SGNs).

164 ed for rapid transmission from hair cells to spiral ganglion neurons (SGNs).

165 the sensory hair cells and their associated spiral ganglion neurons (SGNs).

166 lls (the microphonic) and a second driven by spiral ganglion neurons (the neural response).

167 and also resulted in diminished survival of spiral ganglion neurons after hair cell death.

168 he role of these pathways in the survival of spiral ganglion neurons after noise exposure and during

169 ived neural precursor cells and later in the spiral ganglion neurons along with Neurog1 and NeuroD1,

170 show that alpha2delta3 mRNA is expressed in spiral ganglion neurons and auditory brainstem nuclei an

171 nt of glucocorticoids in age-related loss of spiral ganglion neurons and extensive studies in the cen

172 reduced age-related apoptotic cell death of spiral ganglion neurons and hair cells in the cochlea, a

173 Loss of synapses between spiral ganglion neurons and inner hair cells (IHC synapt

174 n binaural transduction of inner hair cells, spiral ganglion neurons and vestibular hair cells.

175 Furthermore, spiral ganglion neurons are absent in cochleae from Sox2

176 Inner hair cells, auditory synapses and spiral ganglion neurons are all present after noise expo

177 iously that the intrinsic firing features of spiral ganglion neurons are influenced by brain-derived

178 In the cochlea, spiral ganglion neurons are organized in a basal to apic

179 ir cells, whereas delta1 is expressed in all spiral ganglion neurons as well as in their satellite gl

180 the apex and in inner hair cells as well as spiral ganglion neurons at the base.

181 anatomically distinct from other classes of spiral ganglion neurons because they extend a peripheral

182 ctions between cochlear inner hair cells and spiral ganglion neurons can be lost because of noise ove

183 es also suggest that intrinsic properties of spiral ganglion neurons can contribute to the characteri

184 Type I and type II spiral ganglion neurons convey auditory information from

185 h that the electrophysiological phenotype of spiral ganglion neurons depends critically on the precis

186 ause infrared irradiation does not stimulate spiral ganglion neurons directly, it is unlikely to repl

187 Spiral ganglion neurons exhibit spontaneous activity at

188 For instance, in the developing cochlea, spiral ganglion neurons extend their peripheral processe

189 In the NT-3 mutant, almost normal numbers of spiral ganglion neurons form, but fiber outgrowth to the

190 Type I spiral ganglion neurons have a unique role relative to o

191 Disorganized central projections of spiral ganglion neurons in a Wnt/PCP pathway mutant, Pri

192 In addition, Egr2; Atoh1(CKO) mice lose spiral ganglion neurons in the cochlea and AAN neurons d

193 reduces the spontaneous activity of IHCs and spiral ganglion neurons in the developing cochlea and pr

194 indicating that these features characterize spiral ganglion neurons in the fully developed ear.

195 d the peripheral processes of their afferent spiral ganglion neurons in the mouse lasts for 5 days po

196 g properties and ion channel distribution of spiral ganglion neurons in the murine cochlea.

197 the electrophysiological features of murine spiral ganglion neurons in vitro at a time when recordin

198 Spontaneous and sound-evoked responses of spiral ganglion neurons in vivo are strikingly reduced a

199 and within the type I and type II classes of spiral ganglion neurons is necessary to appreciate their

200 In the absence of Isl1, spiral ganglion neurons migrate into the central cochlea

201 F1 and apoptosis in the stria vascularis and spiral ganglion neurons of the inner ear, and progressiv

202 cells (OHCs) release glutamate onto Type II spiral ganglion neurons only when exposed to loud sound,

203 no neuroanatomically recognizable mapping of spiral ganglion neurons onto distinct locations in the c

204 In the cochlea, spiral ganglion neurons play a critical role in hearing

205 These results suggest that spiral ganglion neurons possess electrophysiological mec

206 Type II spiral ganglion neurons provide afferent innervation to

207 Quantification of Fzd3 expression in spiral ganglion neurons show a gradient of expression wi

208 In vivo recordings from postsynaptic spiral ganglion neurons showed a use-dependent reduction

209 Transcriptome analysis of spiral ganglion neurons shows that Isl1 regulates neurog

210 3 (NT-3) synergistically enhance survival of spiral ganglion neurons such that simultaneous exposure

211 characterized changes in both hair cells and spiral ganglion neurons that may be relevant for early s

212 nnervation of the inner hair cells by type I spiral ganglion neurons was normal.

213 s, Deiters' and pillar cells, in a subset of spiral ganglion neurons, and in glial cells.

214 not due to a loss of cochlear hair cells or spiral ganglion neurons, both of which normally express

215 information is conveyed into the CNS via the spiral ganglion neurons, cells that possess distinctive

216 ner ear was immunolocalized predominantly to spiral ganglion neurons, indicating that DFNB86 deafness

217 no evident pathology among supporting cells, spiral ganglion neurons, or cells of the cochlear latera

218 ral aspects of the cochlea are innervated by spiral ganglion neurons, presumably under the tropic inf

219 a three-neuron pathway consisting of type I spiral ganglion neurons, reflex interneurons in the coch

220 physical properties of the auditory neurons (spiral ganglion neurons, SGNs) stimulated in electrical

221 lly high density of similar neurons (type-II spiral ganglion neurons, SGNs), we hypothesise that thei

222 O2.1/Slick) to the primary auditory neurons (spiral ganglion neurons, SGNs).

223 sed in the adult mouse cochlea including the spiral ganglion neurons, suggesting changes in expressio

224 xpression of TMC1 protein in the hair cells, spiral ganglion neurons, supporting cells, and stria lig

225 nd are likely to form connections with adult spiral ganglion neurons, supporting that Myc and Notch1

226 In spiral ganglion neurons, the primary afferents in the co

227 correlated activity in inner hair cells and spiral ganglion neurons, which begins at birth and follo

228 n both embryonic SAG neurons and adult mouse spiral ganglion neurons.

229 ong-term function of auditory hair cells and spiral ganglion neurons.

230 ia vascularis and was also detectable in the spiral ganglion neurons.

231 t, transmission, and output functions of the spiral ganglion neurons.

232 Cx30 labeling was seen in the hair cells and spiral ganglion neurons.

233 g the length of the mouse organ of Corti and spiral ganglion neurons.

234 ncentration dependence and mode of action on spiral ganglion neurons.

235 sion toward the apex in inner hair cells and spiral ganglion neurons.

236 characteristic firing features of postnatal spiral ganglion neurons.

237 synapse between the inner hair cells and the spiral ganglion neurons.

238 ecificity in vitro for both mouse and gerbil spiral ganglion neurons.

239 information from inner hair cells (IHCs) to spiral ganglion neurons.

240 TMPRSS3 expression in the hair cells and the spiral ganglion neurons.

241 a spatially narrow optogenetic excitation of spiral ganglion neurons.

242 synapses between inner hair cells (IHCs) and spiral ganglion neurons.

243 encoding of sound onset in the postsynaptic spiral ganglion neurons.

244 wave I latency, consistent with apoptosis of spiral ganglion neurons.

245 RSS3 delivery rescues the hair cells and the spiral ganglions neurons.

246 Selective loss of TrkC neurons in the spiral ganglion of Brn3a(-/-) cochlea leads to an innerv

247 al, labeling a small cluster of cells in the spiral ganglion of each cochlea.

248 ular injections of Neurobiotin (NB) into the spiral ganglion of the basal cochlea.

249 cochlear nucleus neurons via the OHC-Type II spiral ganglion pathway.

250 This suggests that diverse spiral ganglion phenotypes provide a rich substrate to s

251 indicate that the tonotopic organization of spiral ganglion projections to the cochlear nucleus is a

252 To understand better the sophistication of spiral ganglion response properties, we compared somatic

253 vating the organ of Corti originate from the spiral ganglion, roughly 95% of which innervate exclusiv

254 e found in microdissected organ of Corti and spiral ganglion samples.

255 Morphometric evaluation of spiral ganglion (SG) cell somata within Rosenthal's cana

256 Proper structural organization of spiral ganglion (SG) innervation is crucial for normal h

257 In the cochlea, spiral ganglion (SG) neuron survival is strongly depende

258 ptor had a predominant expression at type II spiral ganglion (SG) neurons and the synaptic areas unde

259 Postnatal development and survival of spiral ganglion (SG) neurons depend on both neural activ

260 tion was seen in satellite cells surrounding spiral ganglion (SG) neurons from postnatal month 1 onwa

261 hlear implant promotes increased survival of spiral ganglion (SG) neurons in animals deafened early i

262 , we found that (1) ASIC2 was present in the spiral ganglion (SG) neurons in the adult cochlea and th

263 Most spiral ganglion (SG) neurons in the middle and basal tur

264 on of the auditory sensory hair cells or the spiral ganglion (SG) neurons that innervate the hair cel

265 und information from the ear to the brain by spiral ganglion (SG) neurons.

266 wann cells myelinating the soma and fiber of spiral ganglion (SG) neurons.

267 own to interact with EphA4, are expressed by spiral ganglion (SG) neurons.

268 apable of releasing vesicular glutamate onto spiral ganglion (SG) neurons: in this case, onto the spa

269 tory nerve projections from the cat cochlear spiral ganglion (SG) to the cochlear nucleus (CN).

270 e6 was localized in the organ of Corti (OC), spiral ganglion (SG), stria vascularis (SV), and afferen

271 ment in the auditory pathway, neurons in the spiral ganglion shape the initial coding of sound stimul

272 toward autoimmune hearing loss, ototoxicity, spiral ganglion survival, and genetic forms of hearing l

273 t of the rat AN projecting from the cochlear spiral ganglion to brainstem cochlear nuclei.

274 ned intact with the corresponding portion of spiral ganglion to investigate excitotoxic damage to IHC

275 opment of the tonotopic projections from the spiral ganglion to the cochlear nucleus during the perio

276 all sectors (300-500 microm) of the cochlear spiral ganglion, to study the projections of auditory ne

277 t, hearing loss and damage in hair cells and spiral ganglion was determined by noise-induced oxidativ

278 PLP1(+) glial cells from the spiral ganglion were identified as neural progenitors, w