ライフサイエンスコーパス: splay

1 , the fingers were placed in three levels of splay.

2 d (BA) leaflet laceration to enhance leaflet splay.

3 ow LANF rupture more than steeper antithetic splays.

4 s in both orientations when the fingers were splayed.

5 es formed around the ATPases BRAHMA (BRM) or SPLAYED.

6 BA-BASILICA increased benchtop leaflet tip splay 17%, maximum splay angle 30%, and splay area 23%,

7 us faecalis Cas1-Cas2 selectively binds to a splayed 30-base-pair prespacer bearing 4-nucleotide 3' o

8 The myocardium splayed after laceration, increasing left ventricular ou

9 allel coiled coil whereas the other contains splayed alpha-helices.

10 nstruction of polymers where chain fragments splay, alter their local dynamics, and evolve in their c

11 aging in bipolar swimming in regions of pure splay and bend but switching to unipolar swimming in mix

12 small twist elastic constant compared to the splay and bend constants.

13 es place on the area above electrodes due to splay and bend deformations of nematic liquid crystal al

14 splay and twist in a stripe pattern and then splay and bend in a square lattice of +1 and -1 defects.

15 nematic elastic constants, which facilitates splay and bend of molecular orientations in tactoids but

16 defects provide large pinning energy, while splay and nanoparticles inhibit flux creep.

17 We calculated the energy of splay and tilt deformations necessary to avoid such hydr

18 ation acquires stationary distortions, first splay and twist in a stripe pattern and then splay and b

19 o liquid crystalline deformations with bend, splay and twist; an analogy to cis/trans isomerism in or

20 rameters that supported both between-cluster splay and within-cluster synchrony.

21 er of 20 +/- 6 kcal/mol between the inactive splayed and active short-pitch conformations of Arp2/3 c

22 he distal tyrosinated microtubules were less splayed and were closer to the leading edges of the grow

23 gene defect responsible for heterochromatic splaying and developmental abnormalities maps to chromos

24 hickness minimum at the interface because of splaying and interdigitating lipids.

25 Moreover, 85% of the N-termini are splayed, and the splayed N-terminus can capture transpor

26 of dynein from bipolar spindles caused pole splaying, and when coupled with a monopolar spindle indu

27 ased benchtop leaflet tip splay 17%, maximum splay angle 30%, and splay area 23%, resulting in a more

28 of the molecule, but here the alpha-helices splay apart and are stabilized by the formation of a tai

29 At the C terminus, the helices splay apart and interact with a symmetry-related dimer i

30 uses the VERL molecules to lose cohesion and splay apart creating the hole.

31 cause the integrin alpha and beta chains to splay apart in the cytoplasm.

32 dency of anti-parallel four-way junctions to splay apart, a tendency that is enhanced both by less sc

33 The N and C domains of DraTopIB are splayed apart in an "open" conformation, in which the su

34 T-loop and D-loop are splayed apart showing how A58, normally buried in tRNA,

35 s unique, with transmembrane helices 5 and 6 splayed apart, promoting widening of the intracellular v

36 next to the cleavage site on the 3' side is splayed apart.

37 lso, the TM helices in the outer leaflet are splayed apart.

38 ating that occurs by bundle crossing and the splaying apart of pore-lining helices commanding ion pas

39 their hand in two postures, with the fingers splayed (Apart posture) or pressed together (Together po

40 The U-A cleavage site adopts a splayed-apart conformation with the modelled 2'-O of U p

41 The U7-U8-U9OH 3' end, in a splayed-apart orientation, is sequestered within a basic

42 e C62-A63 step at the cleavage site adopts a splayed-apart orientation, with flexible C62 directed ou

43 antly in the alignment at the cleavage step (splayed-apart vs. base-stacked) and surrounding residues

44 tip splay 17%, maximum splay angle 30%, and splay area 23%, resulting in a more rounded apex and lar

45 c DNA binding protein with high affinity for splayed arm and 3'-flap DNAs.

46 NA structures, including 3' and 5' flap DNA, splayed-arm DNA and dsDNA with 3' and 5' overhangs but l

47 ke HsGEN1, efficiently cleaves HJs, 5 flaps, splayed arms, and replication fork structures.

48 fic DNA structures and preferentially cleave splayed arms, generating DNA double-strand breaks and in

49 drich Syndrome Protein (N-WASp) to inactive, splayed Arp2/3 complex shifts it toward the short-pitch

50 have an intrinsic propensity to adopt saddle-splay arrangements, characterised by the elastic constan

51 Lamellae splay as a consequence of space constraints related to s

52 ipid interface, to calculate lipid tilts and splays, as well as to fit the corresponding distribution

53 es also have centrioles of normal girth that splay at their proximal ends when induced to elongate by

54 in an unusual conformation in which they are splayed at an oblique angle to each other, suggesting th

55 ilus-like appendages with bundles of threads splayed at the tips.

56 atin regulators: the well-studied BRAHMA and SPLAYED ATPases, as well as two closely related non-cano

57 The domain walls involve splay, bend, and twist of the polarization.

58 phases, and even the long-predicted, elusive splay-bend nematic phase.

59 but switching to unipolar swimming in mixed splay-bend regions.

60 op, and interconnected along the tail by the splayed beta-hairpins.

61 Crystallographic analysis shows that splaying between the heteroaryl rings decreases while tw

62 he resultant strong suppression of twist and splay but not bend deformation in the columnar phase, ca

63 The peri-acridyl rings are slightly splayed but remain perfectly planar in all cases.

64 ry bound charge is reduced by a geometrical "splay cancellation" mechanism that does not require free

65 best results are obtained with a mixture of splayed columnar defects and random nanoparticles.

66 ed channels to constructing new channels and splay complexes.

67 e on Fe and valency of S, and both exhibit a splayed configuration with respect to their three mu2S a

68 heir adjoining TM helices into an obligatory splayed configuration, characteristic of the junctional

69 triggered at regions of flow-induced biaxial-splay configurations of the director field, which are un

70 The contributions of splay conformation and internal dynamics of pyrenyl chai

71 l C-terminal extension of TetM with a unique splayed conformation of nucleotides A1492 and A1493 at t

72 ormations, can be rationalized by the saddle-splay contribution to the free energy.

73 tween the last stacked base and its adjacent splayed counterpart, and positioned within the groove of

74 The enhancement of saddle-splay curvature generation and relaxation of lipid compo

75 w that the requirement for generating saddle-splay curvature implies that a decrease in arginine cont

76 the range of lipid compositions where saddle-splay curvature was induced.

77 lipid headgroups in order to generate saddle-splay curvature, a prerequisite to pore formation.

78 Hence, the splay deformation that scales linearly with the aggregat

79 marginally stable against spontaneous saddle splay deformation, which is incompatible with long-range

80 small twist elastic moduli relieve bend and splay deformations by introducing twist deformations.

81 ositional features, such as a sandy crevasse-splay deposit are found further away from the breach.

82 dimentary structures, and prevalent crevasse splay deposits.

83 al spatial relationships such as short ribs, splayed digits, and absent bones.

84 cases remain tethered, which gives rise to a splayed dimer, with implications for origin activation a

85 Unfolding of the linker begins with a splay distortion of proximal loops away from hydrophobic

86 unit distance (away from the inclusion), the splay-distortion component dominates close to the bilaye

87 nts: a compression-expansion component and a splay-distortion component, which includes the consequen

88 he compression-expansion energy but also the splay-distortion energy.

89 kness, the bilayer compression-expansion and splay-distortion moduli, and the inclusion radius (this

90 three contributions: compression-expansion, splay-distortion, and surface tension.

91 substrate was cleaved 90-fold faster than a splayed duplex substrate containing a single to double s

92 double strands to unpaired single strands ("splayed duplexes"), and DNA bulges in vitro.

93 sible for cleavage on Holliday junctions and splayed duplexes.

94 and render the intracellular vestibule less splayed during channel opening in the presence of ATP.

95 We conclude that the splayed dynamic distal ends of microtubules play a key r

96 ore subtle, patterned surfaces enable saddle-splay effects to be both observed and exploited.

97 e spontaneous twist, we determine the saddle-splay elastic constant for chromonic liquid crystals for

98 While the splay elastic constant is in the typical range of 1.5 pN

99 The structure suggests that the splay elastic constant is larger than the bend modulus.

100 asuring M, the ratio of the Gaussian (saddle splay) elastic modulus to the bending elastic modulus of

101 Other fibers showed splayed ends or a lacy meshwork of surrounding protofibr

102 r toroidal droplets, we find that the saddle-splay energy screens the twisting energy, resulting in a

103 The M7.8 event initiated on a splay fault and subsequently propagated along the main E

104 oka Trust is an on-land analog of the modern splay fault at shallow depths (~ 8 km) in the Nankai Tro

105 The larger event nucleated on a splay fault, and then propagated bilaterally ~350 km alo

106 Dynamic splay faulting and sediment failure limit shallow LANF r

107 southern to northern DSF can be explained by splay faults and diffuse offshore deformation.

108 fault plasticity and dynamically reactivated splay faults on shallow deformation and surface displace

109 nclude narrow extensional troughs or graben, splay faults, and multiple low-relief terraces.

110 ar shear bands indicative of newly initiated splay faults, most prominently above LANFs with thick se

111 disordered, non-magnetic, ground state to a splayed ferromagnetic ground state.

112 terface for NA interaction that unexpectedly splays four bound nucleotides into conformations matchin

113 We measured the incremental leaflet splay from BA-BASILICA in vitro.

114 eir engorgement with microtubules (MTs) that splay from the axon shaft.

115 her than that of the L(d) phase and a saddle-splay (Gauss) modulus difference with the Gauss modulus

116 ilayers is sensitive to kappa(m), the saddle splay (Gaussian curvature) elastic modulus of the lipid

117 his is the first determination of the saddle splay (Gaussian) modulus in a lipid system consisting on

118 We show that shallowly-dipping synthetic splays host more coseismic slip and limit shallow LANF r

119 niform, i.e., to be locally bouquet-like or "splayed." However, it is impossible to achieve splay of

120 not require free ions: the charge created by splay in one plane is reduced by splay of an opposite si

121 ent obstruction caused by inadequate leaflet splay in patients having challenging anatomy such as ver

122 ucing phospholipid protrusion and acyl-chain splay in the cholesterol-enriched rigid envelope.

123 de supporting evidence for the presence of a splay in the G(4)-C(9) base pair of the EcoRI binding si

124 lecular orientations in tactoids but hinders splay in the toroids.

125 BA leaflet laceration enhances leaflet splay in vitro and may allow transcatheter aortic valve

126 ngth of the wild type, suggesting that it is splayed in its N-terminal half.

127 of cochlear hair cells are disorganized and splayed in mutant mice, with subsequent degeneration of

128 ents at risk for inadequate BASILICA leaflet splay, including 4 transcatheter aortic valve replacemen

129 The significant decrease in splaying indicates enhanced pi-pi-attraction between the

130 in binds with its dimethylbenzimidazole tail splayed into a side pocket and its corrin ring buried.

131 s develop abnormally and remain immature and splayed into adulthood, corresponding with the early ons

132 , 12-13-nm-wide filaments and filaments that splayed into two 20-25-nm-wide components at one or both

133 The site of splaying involves a small group of destabilizing core re

134 a single sign requires defects and in the B7 splay is accommodated in the form of periodic splay stri

135 a spontaneous electric polarization P , the splay is suppressed since it produces bound electric cha

136 ying of the wHTH domains when Ile was bound; splaying is likely to account for the increased affinity

137 polarization to be locally bouquet-like or "splayed" is expressed.

138 The individual CFETs splay laterally in deep brain tissue during insertion du

139 rkably well-preserved specimen in an unusual splayed-limb and raised-head posture.

140 ng integrative soft-lithography on a backing splayed liquid-crystal elastomer (LCE).

141 ymers increased the amount of induced saddle-splay membrane curvature and broadened the range of lipi

142 A mechanism of action based on saddle-splay membrane curvature generation is broadly enabling,

143 Importantly, saddle-splay membrane curvature generation places constraints o

144 inity eribulin binding sites, most likely at splayed microtubule ends.

145 tion occurs, wherein it conforms to a unique splay-minimizing configuration.

146 structure uniquely presented by the RPo: the splayed minor groove at the double-stranded/single-stran

147 Surprisingly, the splay mode between clusters could enforce synchrony on s

148 teria were also developed and tested for the splay mode in which neurons fire sequentially.

149 otorious in this regard are the polarization splay modulated (B7) phases, in which the symmetry-requi

150 c field which originates in the periodically splay-modulated bulk of the LC rather than by surface st

151 extended to account for nonvanishing saddle splay modulus within lipid monolayers and perturbations

152 elative increase of the material's bend over splay modulus.

153 cusp (prolapse, restriction) and commissure (splaying) morphology; root pathology was less important.

154 ut directional, fields switch between saddle-splay-motivated, spontaneously-polar surface states.

155 r, 85% of the N-termini are splayed, and the splayed N-terminus can capture transport vesicles in vit

156 ranes: defensins selectively generate saddle-splay ("negative Gaussian") membrane curvature in model

157 es by generating topologically active saddle-splay ("negative Gaussian") membrane curvature through m

158 we observe that lowering the pH induces more splayed NTD states and enhances desensitization in GluA2

159 layed." However, it is impossible to achieve splay of a preferred sign everywhere in space unless app

160 Filling space with splay of a single sign requires defects and in the B7 sp

161 created by splay in one plane is reduced by splay of an opposite sign in the orthogonal plane.

162 Electric field-induced splay of molecular orientation, called the Freedericksz

163 ithin the optic tract region, meandering and splaying of axons in the optic tectum, and the induction

164 addition to drc-mutant axonemes resulted in splaying of doublets in the distal region, followed by o

165 ( approximately 1.3 degrees ) but systematic splaying of individual lamellae in the film.

166 ated to passing of the hydration barrier and splaying of lipids to eventually enter either the fully

167 In growth cones and at axon branch points, splaying of looped or bundled microtubules is accompanie

168 dings that suggested a diagnosis of IOM were splaying of muscle fibers by inflammatory infiltrates (n

169 is proposed based on the structure, whereby splaying of the bottom of the pore is possible without r

170 type channels, the R165A mutation results in splaying of the cytoplasmic domains away from the centra

171 N-terminal fraying and C-terminal splaying of the helices, as well as the asymmetry and he

172 isolated trimeric ectodomain, showing that a splaying of the membrane distal domains is required to m

173 s between the RNA G2 nucleotide and Ago, and splaying of the RNA-DNA duplex by two loops exclusive to

174 ffer in their packing interface, causing the splaying of the two sheets in CarG.

175 CodY-Ile derived from the tetramers showed a splaying of the wHTH domains when Ile was bound; splayin

176 The splaying of these domains is also coupled to changes in

177 m the distributions of microscopic tilts and splays of the lipid components.

178 in after considering the influence of saddle splay on the elastic free energy.

179 In a bent configuration the inner helices splay open creating a wide (12 A) entryway.

180 Bundles abandon a compact form and splay open just as they reach a major blood vessel.

181 ferating Cell Nuclear Antigen (PCNA) must be splayed open at one of the subunit-subunit interfaces by

182 SU processome, the ribosomal RNA domains are splayed open by the intervention of assembly factors as

183 The small size and splayed open configuration of the E-F hairpin facilitate

184 clusion for ions in the closed state and are splayed open on activation.

185 extracellular-half of the pore-lining M2 is splayed open, reminiscent of the open conformation, whil

186 dimeric HIP1 crystal structure is partially splayed open.

187 o DNA-binding domains of LacI are capable of splaying open about the tetramerization domain into an e

188 ses partial extraction of a pore subunit and splays open the Ca(V)alpha(2)delta-interaction site.

189 HA trimer compared to native HA with a more splayed-open conformation at the stem base.

190 mpact bundle over hypothalamus, dramatically splay out over thalamus, and circumvent epithalamus as t

191 ch is equivalent to beta-strand 1 in LC8, is splayed out and binds to a crystallographic dimer as an

192 The heads are splayed out and there is even more heterogeneity in the

193 ntly octamers, with cyclase domains randomly splayed out around the PT core.

194 n the current structure, which is has an NTD splayed out with respect to previous structures, and oth

195 Fibrillin-1 filaments splayed out, extending beyond the width of the periodic

196 For this to occur, the highly dynamic, splayed-out microtubule (MT) arrays characteristic of th

197 ard via flexible linker segments in variable splayed-out positions.

198 enylvinyl moiety in the TT isomer of 2Q gets splayed over the helical scaffold such that it is fraugh

199 ion as a replacement of energetically costly splay packing of the aggregates within the curved bipola

200 ive extrapolated-motion protocol to pack the splayed peripheral TM1 and TM2 transmembrane helices alo

201 lly elongated, are frequently bent, and have splayed poles by prometaphase.

202 ring, low posture and clonus and potentiated splayed postural effects.

203 chattering, tremor/trembling, head weaving, splayed posture, clonus and wet dog shakes.

204 polar smectic liquid crystals in which local splay prevails in the form of periodic supermolecular-sc

205 Depleted of nucleotide, NSF converts to a "splayed" protease-sensitive conformation that reveals it

206 We propose that the formation of splayed REEP/reticulon dimers is responsible for ER tubu

207 that Tctp deficiency results in stunted and splayed retinotectal projections that fail to innervate

208 membrane leafs to display a heterogeneity in splay rigidities.

209 namic assembly and disassembly, bundling and splaying, severing, and rapid transport as well as integ

210 Skinny and splayed spermatid centrioles can still recruit a proxima

211 on of both Kid and NuMA in stark contrast to splayed spindle poles observed after perturbation of NuM

212 conformation that resembles a T-shape with a splayed stem.

213 ons for the nine Usher-associated genes have splayed stereocilia, and some show delayed maturation of

214 play is accommodated in the form of periodic splay stripes spaced by defects and coupled to smectic l

215 ibility of guiding polarization by embedding splay structures in uniform backgrounds.

216 ntage of the flexoelectric effect and design splay structures that geometrically define the polarizat

217 t the SWI2/SNF2 chromatin-remodeling ATPases SPLAYED (SYD) and BRAHMA (BRM) are redundantly required

218 The SPLAYED (SYD) gene product acts with LFY to regulate sho

219 ly important target of the SNF2-class ATPase SPLAYED (SYD) in the shoot apical meristem of Arabidopsi

220 The SNF2-like chromatin-remodeling ATPase SPLAYED (SYD) was identified as a co-activator of floral

221 s thaliana SWI/SNF ATPases, BRAHMA (BRM) and SPLAYED (SYD), are viable, facilitating investigation of

222 By contrast, a null allele of SPLAYED (SYD), the closest homolog of AtBRM in Arabidops

223 le is known about the subunit composition of SPLAYED (SYD)-containing SWI/SNF complexes in plants.

224 ncluding thickness compression, tension, and splay terms to describe the membrane deformation.

225 g surface spanning the length of the DNA and splays the ends of the protospacer to allow each termina

226 s a hinge motion at a conserved glycine that splays the inner-pore helices wide open.

227 duced in number and were frequently bulbous, splayed, tightly clustered and enlarged.

228 their poles failed to converge, as MTs were splayed to discrete positions rendering deformed arrays.

229 the external milieu by means of gaps between splayed transmembrane helices.

230 l formation occurs when cracked or partially splayed trimers bind and penetrate the bilayer.

231 es that may be formed as a result, including splay-twist analogues of blue phases.

232 helixes within each S100beta subunit form a splayed-type four-helix bundle (four perpendicular helix

233 ngence arising from crystallite twisting and splaying under confinement.

234 risk for inadequate anterior mitral leaflet splay underwent BA-LAMPOON.

235 28-(127-588) comprises two RecA-like domains splayed widely apart.

236 bic fissure in bilayers for stalk formation, splay within the expanding hemifusion diaphragm, and fis

237 The splayed Y junction defines a class III substrate having