ライフサイエンスコーパス: spleen

1 olated from aborted and stillborn goat fetal spleens).

2 individual nerve cell bodies innervating the spleen.

3 hi) monocytes were identified in vivo in the spleen.

4 e surface of erythrocytes to the APCs in the spleen.

5 (SL4-RFP) (1 x 10(6)) were injected into the spleen.

6 s compared with those within both islets and spleen.

7 cells were in close proximity in kidney and spleen.

8 peptidome of the pancreatic lymph nodes and spleen.

9 lls from human fetal liver, bone marrow, and spleen.

10 is function and are found in all SLOs except spleen.

11 ntation, accumulated in joint tissue and the spleen.

12 ir retention in blood-exposed regions of the spleen.

13 amedullary sites: in the inflamed joints and spleen.

14 irus (MCMV) displayed elevated titers in the spleen.

15 ontrast to AIF1, AIF1L was also not found in spleen.

16 nd CD11b(+) IL-12(+) cells in the uterus and spleen.

17 gulation of the c-MYC protein level in mouse spleen.

18 -dependent red pulp macrophages (RPM) of the spleen.

19 hages of peritoneum, lung, and liver but not spleen.

20 to the regulation of humoral immunity in the spleen.

21 Abs significantly lowered viral loads in the spleen.

22 were assessed in the blood, BALF, lungs and spleen.

23 of T cells (CD25 and CD69) isolated from the spleen.

24 d the memory cell pool in both the lungs and spleen.

25 expansion and differentiation of SEPs in the spleen.

26 lations in the microvasculature of the human spleen.

27 intestine and muscle, and beta-sitosterol in spleen.

28 o the antigen-presenting cells (APCs) in the spleen.

29 uency of regulatory T cells in the blood and spleen.

30 s significantly increased in both tumors and spleen.

31 de and Ag-specific Th1 and Th17 cells in the spleen.

32 d the frequency of B cells in allografts and spleen.

33 ansion of effector and memory T cells in the spleen.

34 s extramedullary and occurs primarily in the spleen.

35 vical lymph nodes, inguinal lymph nodes, and spleen.

36 o a lesser extent, viral reactivation in the spleen.

37 es immune responses to myelin antigen in the spleen.

38 omeningitis virus infection in the joint and spleen.

39 tment and increased neutrophil influx in the spleen.

40 ogenic CD103(+) dendritic cells (DCs) in the spleen.

41 l mousepox and controlled MCMV titers in the spleen.

42 arabionts but significant engraftment in the spleens.

43 phages were higher only in TRAP-exposed male spleens.

44 4 cGy/MBq for liver, 3.0 +/- 1.4 cGy/MBq for spleen, 0.055 +/- 0.014 cGy/MBq for total body, 0.21 +/-

45 , P < 0.001), liver (15% +/- 6%, P < 0.001), spleen (28% +/- 13%, P = 0.001), and bowel (44% +/- 13%,

46 an increased neutrophil infiltration to the spleen 5 days postinfection.

47 Compound 1 reduced the parasite load in spleen (98.9%) and liver (95.3%) of infected mice after

48 The spleen acts as a reservoir site for hematopoietic stem a

49 lenge with wild-type UMH9 in the kidneys and spleen after inoculation via the tail vein in a bacterem

50 ining lymph nodes after IN infection nor the spleen after intraperitoneal (IP) infection required M2,

51 osis factor (TNF) and other cytokines in the spleen, although the function of DMN neurons in regulati

52 ine lymphocyte trafficking routes within the spleen, an environment of open blood circulation and she

53 CD151+ T-cell frequencies in the spleen, an organ with increased immune activity, were tw

54 ntibody diversity between the lymph node and spleen and between members of the species.

55 Our findings demonstrate that spleen and blood are quite dissimilar, sharing only a sm

56 observed rapid myeloid cell egress from the spleen and bone marrow by in vivo (19)F-HDL magnetic res

57 ockdown of Grasp55 in leukemic cells reduces spleen and bone marrow tumor burden upon i.v. leukemic e

58 ratio of early-to-late erythroblasts in the spleen and bone marrow, and serum LDH level, consistent

59 ellular site of GT3-Nano localization in the spleen and bone marrow, respectively.

60 In the spleen and circulation, newborn-derived Tregs expressed

61 g the total CD3(+) T cell compartment in the spleen and disengaging the hyperactivation state in the

62 ced late apoptosis of Vi-specific B cells in spleen and early depletion of Vi-specific B cells in bon

63 y differentiated ESAM(+) CD4(+) cDC2s in the spleen and failed to prime CD4(+) T cells in response to

64 expression (> 15%), compared with Tregs from spleen and healthy controls.

65 ammatory Ly6C(hi) CCR2(+) macrophages in the spleen and heart at a steady-state resulting in an infla

66 Single-cell RNA sequencing in mouse spleen and human peripheral blood revealed that only mou

67 Spleen and in vitro PnV-activated macrophages were diffe

68 educed cellularity in the bone marrow and/or spleen and inhibited maturation of pre-, immature, and t

69 reduces SAMD14 expression in bone marrow and spleen and is lethal in a hemolytic anemia mouse model.

70 ects on uptake by the olfactory bulb, liver, spleen and kidney.

71 MSCs localized in liver, lung, brain, heart, spleen and kidneys 48 h after intravenous injection and

72 , and the highest activity uptake was in the spleen and kidneys, particularly in the first hour (33.2

73 ice exhibit increased bacterial loads in the spleen and liver, increased tissue damage, and early (wi

74 rrow, and the highest absorbed doses were in spleen and liver.

75 apidly cleared from the circulation into the spleen and liver; this was associated with rapid upregul

76 igher IFN-gamma(+)CD8(+) T cell responses in spleen and lung and stronger cytotoxicity.

77 genomes in monocytes in blood and M s in the spleen and lung of SIV-infected ART-suppressed macaques.

78 TH1 cytokine transcription were increased in spleen and lymph nodes of Glp1r(-/-) mice.

79 cal hyperplasia, and lymphocyte depletion of spleen and lymph nodes.

80 es and dendritic cells, which infiltrate the spleen and major blood vessels and are accompanied by ab

81 contrasts with lymphoid organs, such as the spleen and mesenteric lymph nodes, where these same cell

82 ocompetent mice, (89)Zr-muS110 uptake in the spleen and other lymphoid tissues decreased and was comp

83 ion of beta-cell autoreactive T cells in the spleen and pancreatic lymph node.

84 CD4(+), CD8(+) T-lymphocytes and NK cells in spleen and PBMCs), and apoptosis in IFNAR1-blocked pregn

85 L-2C) administration are well-defined in the spleen and peripheral lymph nodes, how immune cells in t

86 ents for homeostatic cDC2 positioning in the spleen and provides evidence that localization in blood-

87 fection of multiple target cell types in the spleen and the bone marrow.

88 the tissue tropism of GPgV revealed that the spleen and thymus were the organs bearing the highest vi

89 s to a block in maturation of B cells in the spleen and upregulation of proteins associated with mess

90 primarily produced by CD8(+) T cells in the spleen and was required for the observed changes in both

91 luster to the interfollicular regions of the spleen and were instead displaced to the MZ.

92 translocation of E. coli into the liver and spleen and were more susceptible K. pneumoniae-induced s

93 Spleens and allografts from C57BL/6 recipients were harv

94 Transcriptional profiling of spleens and brains identified genes and pathways differe

95 ationship with bacterial localization in the spleens and livers of STm-infected IFN-gamma(-/-) and T-

96 ence-associated immune cell subsets from the spleens and mesenteric lymph nodes revealed an increase

97 Histology and flow cytometry on spleens and thymi from 3-week-old pups for T- and B-cell

98 e number of polyfunctional T cells in murine spleens and tumors compared to IL-2, and enhances the po

99 tion of bacteria and phages in the lungs and spleen, and 3) lung tissue histopathology.

100 Tissues from the lung, heart, liver, kidney, spleen, and bone marrow (but not the brain) were examine

101 increased myeloid cells in peripheral blood, spleen, and bone marrow, as well as expansion of CD8 T c

102 ndetected levels in the blood, lungs, liver, spleen, and brain and induced bacterial antigen-specific

103 s in the skeletal muscles, diaphragm, heart, spleen, and brain and partially in the lung and kidney.

104 th ART restored CD4+ T cells in whole blood, spleen, and bronchoalveolar lavage (BAL) fluid, but not

105 ns in HIS mice including blood, bone marrow, spleen, and draining lymph nodes.

106 ntage of antigen-specific CD4-T-cells in the spleen, and enhanced overall cytokine-secreting T cell p

107 The bone marrow, spleen, and intestine of Kmt2d(+/betaGeo) mice contained

108 RA concentrations in the liver, serum, skin, spleen, and intestines.

109 least partly, cardiac left ventricle, liver, spleen, and kidney (n = 2) or three 10-min whole-body PE

110 were 37-43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T.

111 aureus infection, bacterial burden in lungs, spleen, and kidneys was significantly decreased in mice

112 cterial loads were detected in murine blood, spleen, and liver tissues.

113 smid DNA, and NPC1 mRNA expression in brain, spleen, and liver were confirmed by quantitative PCR.

114 Cornea, spleen, and liver were harvested at 0, 2, 5, 8, and 14 d

115 ogy and lower bacterial burdens in the lung, spleen, and liver.

116 c dissemination of B anthracis in the blood, spleen, and liver.

117 the functionality of the bone marrow, lungs, spleen, and liver.

118 function predominate in blood, bone marrow, spleen, and lungs and exhibit shared transcriptional pro

119 environments (hypoxia) such as in the liver, spleen, and lymph nodes.

120 (K(D), 2.9 nM), showed uptake in the tumor, spleen, and other lymphoid organs, whereas the human-spe

121 macrophage descendants resided in the adult spleen, and parabiosis experiments showed that these cel

122 ss markers were examined in the lung, heart, spleen, and plasma, and TRAP deposits were quantified in

123 psonized platelets were observed only in the spleen, and TPO levels remained unaltered.

124 Livers, spleens, and kidneys contained increased iron in Pcsk9(-

125 elicobacter felis; 3 months later, stomachs, spleens, and sera were collected, along with macrophages

126 Lung-, spleen- and liver-targeted SORT lipid nanoparticles were

127 germinal center (GC) B cell responses in the spleen are not fully understood.

128 escent erythrocytes that are retained in the spleen are subject to hemolysis.

129 review, we envision the exploitation of the spleen as a source for novel biomarkers and therapeutic

130 contribution of radiosensitive cells in the spleen as opposed to a major contribution of radioresist

131 creased and isoenzyme analysis indicates the spleen as origin.

132 creas SUV ratio minus 1 (SUVR-1) (20-30 min; spleen as reference region) demonstrated a statistically

133 Reference region approaches (spleen as reference) were also investigated.

134 taining of small intestine, heart, liver and spleen as well as in situ hybridization of kidneys.

135 pid composition in white pulp regions of the spleen, as anticipated, based on pathways known to be af

136 ectopic kidneys, aplastic adrenal glands and spleen, as well as atretic trachea and palate defects we

137 cies of IgG-secreting cells (IgG-SCs) in the spleen, as well as for each cells, the Ag affinity of th

138 ily small GTPases or to the upstream kinases spleen-associated tyrosine kinase (SYK) and Lck/Yes-rela

139 O accumulated predominantly in the liver and spleen at 1 and 12 h post administration, with apparent

140 ction (P < 0.05) in viral titer in liver and spleen at day 5 postinfection (d p.i.), although both wi

141 calculated as difference between liver- and spleen-attenuation.

142 Initial uptake in spleen averaged 22% +/- 12% and cleared with a biologic

143 ications, most homed HSCs in bone marrow and spleen became multipotent progenitors and, occasionally,

144 ful engraftment in several tissues including spleen, bone barrow, peripheral blood, and lung, in line

145 o be viral reservoirs including lymph nodes, spleen, bone marrow, and brain among others.

146 in mononuclear cells from peripheral blood, spleen, bone marrow, and lung tissue in a mouse model in

147 elevated in the circulating blood and in the spleen, bone marrow, and lung tissue in BCG-infected mic

148 iron deposition in the liver, heart, lungs, spleen, bone marrow, thyroid and adrenal glands.

149 isted of the kidneys, bladder, liver, heart, spleen, bone marrow, uterus, and remainder of body.

150 A-IL2 than of (18)F-FB-IL2 in liver, kidney, spleen, bone, and bone marrow.

151 nsive CD4 and CD8 T cell responses in blood, spleen, bronchoalveolar lavage and lung lymph nodes.

152 nced the clearance of CHIKV infection in the spleen but had a minimal impact on CHIKV infection in th

153 ssays demonstrated specific binding to human spleen but not lung fibroblasts of the transgenic line e

154 0 with CD3-positive T cells in the tumor and spleen but not with EpCAM expression.

155 the total cell count of the bone marrow and spleen, but it had no effect on erythroid progenitor fre

156 pendent cDC2s were absent selectively in the spleen, but not in the intestine of Taok3 (-/-) and CD11

157 , neutrophils and NK cells isolated from the spleen (by flow cytometry) and the presence of macrophag

158 brain, heart, kidney, liver, lung, ovary and spleen) by tandem mass tag (TMT) labeling followed by ma

159 ministration as seen in the lung, liver, and spleen can be strategically exploited to enhance drug de

160 Spleen cells from mice with pancreatitis had increases i

161 pathway that consists of the vagus nerve to spleen circuit, which has been stimulated with implantab

162 The marginal zone (MZ) of the spleen contains multiple cell types that are involved in

163 Restoring SIGN-R1(+) macrophages to the spleen corrected positioning of DCIR2(+) DCs and rescued

164 ified 67 P. vivax genes whose expression was spleen dependent.

165 Results demonstrated that spleen-dependent antigens are immunogenic in natural inf

166 in more insights, we expressed five P. vivax spleen-dependent genes as recombinant proteins, includin

167 gies to unambiguously track the migration of spleen-derived cells to peripheral tissues.

168 development, whereas their reconstitution by spleen-derived macrophage transplantation restored the s

169 Mice were euthanized on-orbit, livers and spleens dissected, and remaining tissues frozen in situ

170 nt models were used to estimate pancreas and spleen distribution volume.

171 ry burst induces antibiotic tolerance in the spleen during a murine systemic infection.

172 ic IL-17(+)IFN-gamma(+)CD4(+) T cells in the spleen during experimental autoimmune encephalomyelitis.

173 typic comparison of IgG-SCs presented in the spleen during immunization or after recall revealed simi

174 . vivax biology toward deeper studies of the spleen during infections.

175 Baseline bone marrow (BM) and spleen FDG uptake was higher in mycobacterial IRIS speci

176 (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of E

177 The highest uptake was always in spleen, followed by bone marrow.

178 olved in cytoadherence were dependent on the spleen for their expression.

179 wo- and six-days post infection (dpi) in the spleen from both lines, either challenged by NDV or nonc

180 pression of both GDE3 and CB2 in the spleen, spleens from transgenic mice lacking GDE3 displayed doub

181 of brain > liver > kidney > heart > blood > spleen > muscle > intestine > blubber > fur, and in both

182 rotopically into immunosuppressed pigs whose spleens had been removed can sustain perfusion for up to

183 pathway inhibitor-2 were observed in liver, spleen, heart, and kidney tissues of thalassemia interme

184 exed, quantitative proteomics on the brains, spleens, hearts, small intestines, and colons of convent

185 oration, including protease responses in the spleen, high-density lipoproteins in the heart, and glut

186 nistration reduced the activation of several spleen immune cell subsets, the anti-inflammatory effect

187 t was first isolated in Bolivia from a human spleen in 1963.

188 ineated NK cell trafficking to the liver and spleen in an adoptive cell transfer model.

189 xamined post mortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the a

190 se mutant bacteria were more abundant in the spleen, indicating enhanced dissemination of Sterne anth

191 rophils were absent from the bone marrow and spleen, indicating local acquisition of the SiglecF(hi)

192 and normalized norepinephrine levels in the spleen, indicating that heightened, central sTNFalpha si

193 ures in lymphocyte recirculation through the spleen, indicating the existence of separate entry and e

194 iptional analysis of parasites obtained from spleen-intact and splenectomized monkeys, we identified

195 The spleen is a large lymphoid organ located in the abdomen

196 eyed from the blood-stream to the FDC in the spleen is uncertain.

197 e haematopoietic niche (in rodents, also the spleen), is a major site of parasite growth and sexual d

198 I-S1 was also taken up by the lung, spleen, kidney and liver.

199 ion of 800CW-BSA was low in the heart, lung, spleen, kidneys, and liver, but high in the stomach and

200 DOTA-BC8 had a long retention time in liver, spleen, kidneys, and red marrow, and the highest absorbe

201 submandibular glands; left ventricle; liver; spleen; kidneys; bowel; urinary bladder; gluteus muscle;

202 f erythrocyte-delivered nanoparticles to the spleen led to improved antibody response against the ant

203 in increased bacterial dissemination to the spleen, liver, and blood.

204 ociated with increased bacterial load in the spleen, liver, and blood.

205 various organs, and amyloid deposits in the spleen, liver, and kidneys.

206 ere obtained for the regions of interest for spleen, liver, kidneys, testicles (in men), and 2 marrow

207 riety of organ systems, including the lungs, spleen, liver, lymph nodes, pancreas and extrahepatic bi

208 ompared to free IM, which accumulates in the spleen/liver.

209 IgE, cellular composition of BAL, lung, and spleen, lung function, and T-cell polarization were asse

210 n primates for all sites examined (i.e., the spleen, lung, and circulation).

211 ng morphology, with no alterations in heart, spleen, lung, or liver in Leuko-Rapa-treated mice.

212 AM concentration in specific tissues (liver, spleen, lymph nodes, and thymus) was also dependent on d

213 nB1 and increased levels of Cyc-D and p21 in spleen lysates were observed in animals administered con

214 to alter vaccine transfer to lymph nodes and spleen may be the formulation with micron-sized adjuvant

215 Red pulp macrophages (RPMs) of the spleen mediate turnover of billions of senescent erythro

216 and were transfused with 1 x 10(7) of human spleen mononuclear cells reconstituted human CD45(+) cel

217 ic treatment, significantly reduced lung and spleen mycobacterial loads compared to antibiotic treatm

218 ation and persistence in the lymph nodes and spleen of a systemically administered serum albumin (SA)

219 recall, appearance of the IgG-SCs within the spleen of immunized mice was fast (<24 h) and this early

220 (+) T cell populations in thymus, blood, and spleen of MHCIIKR(KI/KI) and March8 (-/-) mice were larg

221 and pancreas, and immune populations in the spleen of mice were analyzed by cytokine multiplex detec

222 +)Ly-6G(-)F4/80(-)) emerged in the liver and spleens of bispecific protein-treated mice.

223 Elevated bacterial burdens were found in the spleens of CO92 Deltapgm-infected animals by 24 h postin

224 , but not IL-17, were also detectable in the spleens of cytokine reporter mice.

225 ted the proportions of myeloid precursors in spleens of Hbbth3/+ mice.

226 Residual mNK cells in spleens of MYC(ON) T-lymphoma-bearing mice exhibit pertu

227 Spleens of TFR2-deficient mice displayed an increase in

228 on deep learning can accurately segment the spleen on CT scans and may help radiologists to detect a

229 earning network was developed to segment the spleen on thorax-abdomen CT scans.

230 Spleen or lymph node cells were analyzed in proliferatio

231 categorised as mild (minimal fluid by liver, spleen, or pelvis), moderate (<1 cm fluid), or severe (f

232 nity on individual live T cells from thymus, spleen, pancreatic lymph nodes, and islets before and af

233 y/sternotomy (12%), angioembolization of the spleen/pelvis/liver/other (9%), neck (9%), craniotomy (4

234 ease in Nrp1(+)Foxp3(-) CD4 T cells in their spleens, periaortic lymph nodes, and aortas, compared wi

235 toward IgD(dim)IgM(+) B cell populations in spleen, peritoneum and peripheral blood.

236 These results suggest that the spleen plays a major role in expression of parasite prot

237 e), they were predominantly delivered to the spleen rather than lungs, which is conventionally the ta

238 ory responses in the blood, heart, lung, and spleen remained unchanged.

239 staining was observed compared with control spleens resected after trauma (P < 0.001).

240 ivided into recirculating T-bet(lo) MBCs and spleen-resident T-bet(hi) MBCs.

241 impacts other effector organs, including the spleen, resulting in spinal cord injury-induced immunode

242 Upon isolating human spleen RPMs, we noted a substantial lack of macrophages

243 lowing splenectomy performed for spontaneous spleen rupture, or to cure refractory autoimmune haemoly

244 pancreatic lymph node samples compared with spleen samples.

245 ed genes (DEGs) in at least one tissue where spleen showed the highest number of DEGs (1371).

246 is due, in large part, to a lack of in vivo, spleen-specific lineage tagging strategies.

247 ident MBC gene signature as well as gut- and spleen-specific signatures.

248 In spleen specimens of thalassemia major patients, a higher

249 major expression of both GDE3 and CB2 in the spleen, spleens from transgenic mice lacking GDE3 displa

250 es of histocytes with neutrophils within the spleen suggesting an ongoing or resolving injury.

251 in the tumor, while did not increase in the spleen, suggesting that PnV-activated macrophages were l

252 Also, in the spleen, T lymphopenia, especially after in vitro restimu

253 dest TH1/2/17 cytokine storm in the lung and spleen that peaked by day 2, and an extended chemokine s

254 ing protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling, resp

255 cells were detectable at T-B borders in the spleen; there, they proliferated in a T cell-dependent m

256 In an unbiased analysis of spleens, this integrated technology enabled identificati

257 haematopoietic system in mice, including the spleen, thymus, and haematopoietic stem and progenitor c

258 luates the mechanical properties of liver or spleen tissue in concordance to the propagation of mecha

259 yte and macrophage subpopulations from human spleen tissue led to the identification of erythrocytes

260 onfirmed the presence of CB2 in prairie vole spleen tissue using [3H] CP-55,940.

261 MALDI-MSI experiments on spleen tissues from intravenously injected mice indicate

262 Monocyte trafficking from the spleen to the myocardium and subsequent phenotype switch

263 we describe a detailed practical protocol of spleen transplantation and its evaluation for long-term

264 ROS generation and spleen tyrosine kinase (Syk) activation induced by heme

265 estigated the implication of FcgammaRIIa and spleen tyrosine kinase (Syk) in DC activation and showed

266 asari et al. find a role for the nonreceptor spleen tyrosine kinase (SYK) in upstream signaling leadi

267 ibits antigen-induced, FcepsilonRI-dependent spleen tyrosine kinase (Syk) phosphorylation and downstr

268 e, siRNA depletion of Mincle and its adaptor spleen tyrosine kinase (Syk), and Syk pharmacological in

269 ntral role of a nonreceptor tyrosine kinase, spleen tyrosine kinase (SYK), in mediating osteomyelitis

270 ntly downregulated gene in both datasets was spleen tyrosine kinase (SYK).

271 results were obtained with mice lacking the spleen-tyrosine kinase Syk in platelets, an essential co

272 ulation of these plain SNPs in the liver and spleen upon IV administration and the duration needed fo

273 [(89)Zr]Zr-DFO-N-suc-muS110 spleen uptake was lower in immunodeficient than in immun

274 G 110 showed similar tumor uptake but lacked spleen uptake.

275 and lung uptake, but not in kidney, liver or spleen uptake.

276 s to the recruitment of B and T cells to the spleen, vaginal and intestinal mucosae, for example CCL2

277 In vivo and ex vivo USF imaging of the mouse spleen via intravenous injections was also successfully

278 scle (via intramuscular injection), lung and spleen (via intravenous injection), and brain (via later

279 y and 35% or more reduction from baseline in spleen volume) at 32 weeeks was previously reported.

280 points, including grade >= 3 adverse events, spleen volume, symptom assessment, genetic correlates of

281 wCV in the salivary glands and spleen was 8.9% and 10.7% SUV(mean), respectively.

282 Decreased production of 2-AG in whole spleen was also observed, supporting the in vivo relevan

283 Bacterial burden in blood, lung, liver, and spleen was neither increased nor decreased in rats treat

284 OASL in NDV challenged versus nonchallenged spleen was observed in Leghorns at 2 dpi.

285 y video health checks and body, adrenal, and spleen weights of 37d-flight (FLT) mice did not differ f

286 Blood, BALF, lungs and spleen were collected after 5 weeks of exposure to eithe

287 , intestine, kidney, liver, lung, muscle and spleen were determined on day 21.

288 V burden in joint-associated tissues and the spleen were equivalent in wild-type (WT) and CD8alpha(-/

289 ng units per milliliter) in liver, lung, and spleen were not different between groups, and the phagoc

290 Decreased neutrophil numbers in the spleen were observed during acute infection with myeloid

291 frontal cortex (PFC), hippocampus (HPC), and spleen were then collected and analyzed for metabolomic

292 Blood, livers, and spleens were analyzed using transcriptome sequencing (RN

293 entative normal tissues (salivary glands and spleen), were segmented separately by 2 readers.

294 lation and STING activation in the liver and spleen, which we identify as dose limiting organs.

295 plasma cytokines, a significant reduction in spleen white pulp, and lymphocyte infiltration in the li

296 ve antibody titers and persist mainly in the spleen with restricted trafficking between tissues.

297 ffector and regulatory CD4(+) T cells in the spleen, with CD4(+) T cells from LMP7(-)(/-) mice showin

298 y was restricted to the BM, lungs, liver and spleen, with no accumulation in the kidneys, brain, hear

299 he number of NK cells in the bone marrow and spleen without affecting NK cell maturation.

300 present initially in bone marrow, liver and spleen without any lymphadenopathy (referred to as BLS-t