ライフサイエンスコーパス: spliceosomal

1 nuclear RNAs (snRNAs) incompletely processed spliceosomal.

2 rminal RNA Recognition Motif (RRM) domain of spliceosomal A protein of the U1 small nuclear ribonucle

3 the Tetrahymena group I intron or the yeast spliceosomal ACT1 intron at the same location is not sub

4 as a protein that is intimately involved in spliceosomal activation and the catalytic reaction.

5 al proteins, revealing a new role of Brr2 in spliceosomal activation in addition to U4/U6 unwinding.

6 for retaining U5 and U6 snRNPs during/after spliceosomal activation through its interaction with snR

7 owever, the truncation significantly impairs spliceosomal activation, leading to a dramatic reduction

8 ible for U4/U6 unwinding, a critical step in spliceosomal activation.

9 /U6 RNA duplex, which is a critical step for spliceosomal activation.

10 ineTeen complex (NTC) which is important for spliceosomal activation.

11 ies however, reveal that HDACs interact with spliceosomal and ribonucleoprotein complexes, actively c

12 omplex in OIS and demonstrate a link between spliceosomal and ribosomal components, functioning indep

13 modification of RNA substrates to fine-tune spliceosomal and rRNA function, accommodating changing r

14 ctivate essential RNAs, including ribosomal, spliceosomal and telomeric RNAs, cisplatin binding sites

15 on, SMN-C1 treatment increases the levels of spliceosomal and U7 small-nuclear RNAs and corrects RNA

16 thase to modify newly synthesized ribosomal, spliceosomal, and possibly other RNAs.

17 e U1 snRNP to specific pre-mRNAs, permitting spliceosomal assembly and splicing.

18 licing in rnp-4f, which encodes a Drosophila spliceosomal assembly factor.

19 These results identify the A complex as the spliceosomal assembly step dedicated to splice site pair

20 zation/calcium signaling controls a critical spliceosomal assembly step to regulate the variant subun

21 gesting a previously unknown role of Prp8 in spliceosomal assembly through its interaction with U1 sn

22 These results demonstrate the early spliceosomal association of Bud31 and provide plausible

23 Sde2 facilitates spliceosomal association of Cactin/Cay1, with a function

24 tween the TBP-binding module of SAGA and the spliceosomal ATPase Prp5p mediate a balance between tran

25 t at a lower level than the WT Brr2) and the spliceosomal B complex.

26 ate stage during conversion of pre-catalytic spliceosomal B complexes into activated B(act) complexes

27 e activity involved in the activation of the spliceosomal B-complex, we investigated the structural a

28 The domain VI dynamics closely parallel spliceosomal branch-site helix movement and provide stro

29 ide insights into substrate selection during spliceosomal branching catalysis; additionally, this sys

30 Recently reported structures of the spliceosomal C complex with the cleaved 5' exon and lari

31 trons, and the property that links them with spliceosomal catalysis, is their ability to undergo spli

32 myeloid malignancy development, and identify spliceosomal changes as a mediator of IDH2-mutant leukae

33 ring binds to the TER1 precursor, stimulates spliceosomal cleavage and promotes the hypermethylation

34 that the widespread and basal N. crassa-type spliceosomal cleavage mechanism is more ancestral than t

35 The discovery of a prevalent, yet distinct, spliceosomal cleavage mechanism throughout diverse funga

36 The first spliceosomal cleavage reaction generates the mature 3' e

37 tly upstream and partly overlapping with the spliceosomal cleavage site is a putative binding site fo

38 ombe telomerase RNA (SpTER1) is generated by spliceosomal cleavage, a reaction that corresponds to th

39 nts the second step of splicing and promotes spliceosomal cleavage.

40 SON is a key component of the spliceosomal complex and a critical mediator of constitu

41 tri-snRNP is a 1.5-megadalton pre-assembled spliceosomal complex comprising U5 small nuclear RNA (sn

42 o produce a 29-A density map of a stable 37S spliceosomal complex from the genetically tractable fiss

43 The U5 spliceosomal complex of eight highly conserved proteins

44 rabbits received a peptide from the Sm B/B' spliceosomal complex previously shown to be immunogenic

45 NKAP interacts with HDAC3 and post-catalytic spliceosomal complex proteins.

46 protein that associates with the activated B spliceosomal complex SKIP.

47 cle and the pre-mRNA results in a productive spliceosomal complex, leading to intermediates and produ

48 Gemin5, a component of the spliceosomal complex, was chosen for further study.

49 n by regulating the function of the U2 snRNA spliceosomal complex.

50 e the NTR, Prp43_Ntr1GP disassembles earlier spliceosomal complexes (A, B, B(act)), indicating that N

51 ermination of cryo-EM structures for several spliceosomal complexes has provided deep insights into i

52 ctors in nuclear speckles and assembles into spliceosomal complexes in association with low-abundance

53 We propose that spliceosomal complexes provide a platform for siRNA gene

54 kewise, inspection of BRR2 structures within spliceosomal complexes revealed that the cassettes occup

55 Early spliceosomal complexes were also immunoprecipitated by t

56 we demonstrate to have multiple partners in spliceosomal complexes.

57 t cryo-electron microscopy structures of the spliceosomal complexes.

58 by promoting the formation of ATP-dependent spliceosomal complexes.

59 pered progress in analyzing the structure of spliceosomal complexes.

60 U1-CPAFs are distinct from U1-spliceosomal complexes; they include CPA's three main su

61 ght on the dynamic assembly of this critical spliceosomal component and elucidate the molecular inter

62 Pre-mRNA processing factor 3 (PRPF3) is a spliceosomal component essential for pre-mRNA processing

63 Ott1 (Rbm15), a spliceosomal component originally identified as a fusion

64 F65) with the splicing factor 1 (SF1) or the spliceosomal component SF3b155 are exchanged during a cr

65 ided deep insights into interactions between spliceosomal components and structural changes of the sp

66 , the recognition of the intron substrate by spliceosomal components and the assembly of these compon

67 Growing evidence suggests that core spliceosomal components differentially affect RNA proces

68 events further assembly of the U1 snRNP with spliceosomal components downstream.

69 TDP-43 also recruits key spliceosomal components from Cajal bodies.

70 ing competition for specific binding between spliceosomal components involved in recognition of 5' an

71 actors is consistent with the elimination of spliceosomal components that play a peripheral or modula

72 pre-mRNA maturation through the bridging of spliceosomal components to H3K4me3 via CHD1.

73 rolled by splicing regulators, which recruit spliceosomal components to initiate pre-mRNA splicing.

74 fied many previously unknown interactions of spliceosomal components with the pre-mRNA.

75 n the absence of the approximately 200 other spliceosomal components, performs a two-step reaction wi

76 t GFP-CDKC2 fusion proteins co-localize with spliceosomal components, that the expression of CDKC2 mo

77 or basic metabolites and retains a subset of spliceosomal components, with a transcriptome broadly fo

78 vival of Motor Neuron, a master assembler of spliceosomal components.

79 the mRNA export complex TREX-2 and multiple spliceosomal components.

80 y1p acts together with U6 snRNA to promote a spliceosomal conformation favorable for first-step chemi

81 mplex recovered with a mutant version of the spliceosomal core protein Prp8p.

82 SCNM1 is also co-immunoprecipitated with the spliceosomal core Smith (Sm) proteins and demonstrates f

83 This revealed seven peaks of spliceosomal crosslinking around branchpoints (BPs) and

84 act modus operandi of Prp43 and of all other spliceosomal DEAH-box RNA helicases is still elusive.

85 c maturases in bacteria into their versatile spliceosomal descendants in the nucleus.

86 M interaction also inhibits the formation of spliceosomal E complex and splicing.

87 -electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a

88 ate pre-mRNAs, have been an early feature of spliceosomal evolution?

89 e monoclonal antibody SC35, raised against a spliceosomal extract, is frequently used to mark NS.

90 ions related to RNA processing such as SF3B1 spliceosomal factor.

91 Core spliceosomal factors (such as SF3B1 and U2AF1) associate

92 Defective or imbalanced expression of spliceosomal factors has been linked to human disease; h

93 h of BPs affect the crosslinking patterns of spliceosomal factors, which bind more efficiently upstre

94 uncharacterized protein found in some human spliceosomal fractions.

95 els of snoRNA that target spliceosomal RNAs, spliceosomal function, and heart development.

96 efore are likely indirect effects of altered spliceosomal function, consistent with prior data showin

97 Many fundamental aspects of spliceosomal function, including the identity of catalyt

98 Spliceosomal gene mutations are always heterozygous and

99 d pharmacologic evidence that leukemias with spliceosomal gene mutations are preferentially susceptib

100 of the mechanistic and biological effects of spliceosomal gene mutations in MDSs as well as the regul

101 tiology and highlights the complexity of the spliceosomal gene network.

102 f expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis.

103 Engineered variable expression of the spliceosomal gene SNRNP40 promotes metastasis, attributa

104 sis identified multiple mutations in another spliceosomal gene, SUGP1, that correlated with significa

105 Spliceosomal genes are probably tumor suppressors, and t

106 Mutations affecting spliceosomal genes that result in defective splicing are

107 Recently, recurrent mutations of spliceosomal genes were frequently identified in myeloid

108 asms was performed, and somatic mutations in spliceosomal genes were identified.

109 oding splicing factors (which we refer to as spliceosomal genes) are commonly found in patients with

110 e identified additional somatic mutations in spliceosomal genes, including SF3B1, U2AF1, and SRSF2.

111 One of these spliceosomal genes, U2AF1, was affected by canonical som

112 ying the ordered addition of Brr2, a pivotal spliceosomal helicase, to the U5 snRNP.

113 standing of the functions of Brr2p and other spliceosomal helicases has been limited by lack of knowl

114 intron-specific splicing function and early spliceosomal interactions and suggests links with cell c

115 Studies of spliceosomal interactions are challenging due to their d

116 ween unspliced RNA and small nuclear RNAs in spliceosomal intermediates.

117 lex formed between the branch site (BS) of a spliceosomal intron and its cognate sequence in U2 snRNA

118 ces from the well-known orthologous U12-type spliceosomal intron database U12DB.

119 The most obvious spliceosomal intron duplication pathways involve an RNA

120 ith host genomic loci and contained numerous spliceosomal introns and large duplications, suggesting

121 r the emergence of eukaryotic retroelements, spliceosomal introns and other key components of the spl

122 sons thought to be evolutionary ancestors of spliceosomal introns and retroelements in eukaryotes.

123 that are widely held to be the ancestors of spliceosomal introns and retrotransposons that insert in

124 d to share common ancestry with both nuclear spliceosomal introns and retrotransposons, which collect

125 rons are the putative progenitors of nuclear spliceosomal introns and use the same two-step splicing

126 evolutionary perspective because the nuclear spliceosomal introns are thought to derive from group II

127 Spliceosomal introns are ubiquitous non-coding RNAs that

128 ypothesized to be the progenitor not only of spliceosomal introns but also of non-LTR retrotransposon

129 f S. cerevisiae and, more generally, excised spliceosomal introns can have biological functions.

130 Spliceosomal introns can occupy nearby rather than ident

131 To trace the evolutionary trajectory of spliceosomal introns from available genomes under a unif

132 nts of the spliceosome and differ from other spliceosomal introns in having a short distance between

133 A new study reports creation of spliceosomal introns in multiple related fungal species

134 II introns, tRNA and/or archaeal introns and spliceosomal introns in nuclear pre-mRNA.

135 The origin of spliceosomal introns is a vexing problem.

136 ring between U2 snRNA and the branch site of spliceosomal introns is essential for spliceosome assemb

137 ionary forces responsible for the origins of spliceosomal introns remain mysterious.

138 the Stentor genome, we discover the smallest spliceosomal introns reported for any species.

139 Thus, the primordial spliceosomal introns were, most likely, U2-type.

140 een proposed for the origin and evolution of spliceosomal introns, a hallmark of eukaryotic genes.

141 e commonly believed to be the progenitors of spliceosomal introns, but they are notably absent from n

142 ron loss or evolution into protein-dependent spliceosomal introns, consistent with the bacterial grou

143 ncerning the evolution of the two classes of spliceosomal introns, finding support for the class conv

144 evolution, as they are likely progenitors of spliceosomal introns, retroelements, and other machinery

145 The two types of eukaryotic spliceosomal introns, U2 and U12, possess different spli

146 of splicing reactions for both group II and spliceosomal introns.

147 m nuclear genomes and drove the evolution of spliceosomal introns.

148 fer, reside in a genome of 19.7 Mbp with 235 spliceosomal introns.

149 bed; some of the latter contained functional spliceosomal introns.

150 to promote the splicing of both group II and spliceosomal introns.

151 RNAs that are ancestrally related to nuclear spliceosomal introns.

152 hanistically similar to the metazoan nuclear spliceosomal introns; therefore, group II introns have b

153 These included the U1 spliceosomal lncRNA and RP11-462G22.1, each entailing se

154 hermore, we identify high variability in the spliceosomal machinery gene set.

155 egenerate mammalian splice sites by the core spliceosomal machinery is regulated by several protein f

156 Somatic mutations of the spliceosomal machinery occur frequently in adult patient

157 scape in PDAC with underlying changes in the spliceosomal machinery.

158 urther resulted in preferential lethality of spliceosomal mutant AML, providing a strategy for treatm

159 Our data suggest that many rare and private spliceosomal mutations contribute to disease pathogenesi

160 These spliceosomal mutations often occur in a mutually exclusi

161 However, a subset of patients carries spliceosomal mutations that affect non-hotspot residues,

162 have identified recurrent spliceosomal mutations that induced genome-wide splicing

163 , and Inoue et al. have identified recurrent spliceosomal mutations that induced genome-wide splicing

164 characterization of diverse rare and private spliceosomal mutations to infer their likely disease rel

165 To determine the functional effect of spliceosomal mutations, we evaluated pre-mRNA splicing p

166 and patient-derived xenograft AMLs carrying spliceosomal mutations.

167 Most "spliceosomal" mutations affect specific hotspot residues

168 Our data expose a spliceosomal progression cycle of U2 stem IIa formation,

169 on and uncover a non-enzymatic function of a spliceosomal proline isomerase.

170 We show that human eIF4G-like spliceosomal protein (h)CWC22 directly interacts with th

171 esults also demonstrate an analogy between a spliceosomal protein and ribosomal proteins that insert

172 iate with splicing factor 3B1 (SF3B1), a key spliceosomal protein of the U2 small nuclear ribonucleop

173 human orthologue of Saccharomyces cerevisiae spliceosomal protein Prp2, an RNA-dependent ATPase that

174 elomerase, and retroviral RTs as well as the spliceosomal protein Prp8 in eukaryotes.

175 The auxiliary spliceosomal protein SCNM1 contributes to recognition of

176 The gene encoding the core spliceosomal protein SF3B1 is the most frequently mutate

177 Beag encodes a spliceosomal protein similar to splicing factors in huma

178 isrupted one allele of the gene encoding the spliceosomal protein SmD3, creating a model of haploinsu

179 amers of I-E(k)-containing peptides from the spliceosomal protein U1-70 that specifically stain disti

180 rminal RNA recognition motif (RRM) domain of spliceosomal protein U1A, interacting with its RNA targe

181 and interacts with RNA polymerase II and the spliceosomal protein U5-15kD.

182 provide a mechanistic link between a mutant spliceosomal protein, alterations in the splicing of key

183 SF3B1, which encodes an essential spliceosomal protein, is frequently mutated in myelodysp

184 Recently, mutations in a gene encoding a spliceosomal protein, SF3B1, were discovered in a distin

185 B1 and found that levels of a poorly studied spliceosomal protein, SUGP1, were reduced in mutant spli

186 tified that mutations in genes encoding core spliceosomal proteins and accessory regulatory splicing

187 xpression by promoting methylation of the Sm spliceosomal proteins and significantly altering the spl

188 However, the functions of many auxiliary spliceosomal proteins are still unknown.

189 Mutations affecting spliceosomal proteins are the most common mutations in p

190 Recently, recurrent mutations in numerous spliceosomal proteins have been associated with a number

191 STIPL1 is a homolog of the spliceosomal proteins TFP11 (Homo sapiens) and Ntr1p (Sa

192 mutations in predicted splicing factors and spliceosomal proteins that affect cell fate, the circadi

193 Almost 50% of the human spliceosomal proteins were predicted to be intrinsically

194 3 subsets: 1) 60 kd Ro, 52-kd Ro, and La, 2) spliceosomal proteins, and 3) double-stranded DNA (dsDNA

195 cancer and that mutations in genes encoding spliceosomal proteins, as well as mutations affecting th

196 control deubiquitination of histone H2B and spliceosomal proteins, respectively.

197 s interaction with snRNAs and possibly other spliceosomal proteins, revealing a new role of Brr2 in s

198 ropose that the reversible ubiquitination of spliceosomal proteins, such as Prp3, guides rearrangemen

199 s screening resulted in the isolation of two spliceosomal proteins, U1-70K and U2AF(35) b that are kn

200 molecule via its interaction with HDAC3 and spliceosomal proteins.

201 Here, we report that the spliceosomal Prp19 complex modifies Prp3, a component of

202 in complex with an activating domain of the spliceosomal Prp8 protein at 2.4 angstrom resolution com

203 he similarity between maturases and the core spliceosomal Prp8 protein further supports this intrigui

204 Analysis of spliceosomal RBPs indicates that eCLIP resolves AQR asso

205 Consistently, H2A.Z promotes efficient spliceosomal rearrangements involving the U2 snRNP, as H

206 ion, cytokine activity, protein kinases, RNA spliceosomal ribonucleoproteins, intracellular signaling

207 II gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes.

208 peting stem IIa and stem IIc helices are key spliceosomal RNA elements that optimize juxtaposition of

209 imilar organization and regulation as in the spliceosomal RNA helicase Brr2.

210 signal recognition particle and the yeast U2 spliceosomal RNA homolog.

211 esidues in several non-coding RNAs: tRNA, U2 spliceosomal RNA, and steroid receptor activator RNA.

212 (Met) were vastly underrepresented, while U6 spliceosomal RNA, which functions in the nucleus, was en

213 e-specific 2'-O-methylation of ribosomal and spliceosomal RNAs and are critical for gene expression.

214 ant noncoding RNAs such as tRNAs, rRNAs, and spliceosomal RNAs are also heavily modified and depend o

215 n Prp24 that suppress mutations in U4 and U6 spliceosomal RNAs cluster primarily in the beta-sheet of

216 g specific nucleotides of ribosomal RNAs and spliceosomal RNAs for biochemical modification.

217 ial for ribosome biogenesis, modification of spliceosomal RNAs, and telomerase stability.

218 otected regions within small nucleolar RNAs, spliceosomal RNAs, microRNAs, tRNAs, long noncoding (lnc

219 a link between levels of snoRNA that target spliceosomal RNAs, spliceosomal function, and heart deve

220 ated in the 28S and 18S ribosomal RNAs and 2 spliceosomal RNAs, U2 and U6.

221 -nucleotide subdomain derived from the U2:U6 spliceosomal RNAs.

222 The C-terminal tails of spliceosomal Sm proteins contain symmetrical dimethylarg

223 ith ribonucleoprotein Gemin proteins but not spliceosomal Sm proteins needed for snRNP assembly.

224 lts in the complete loss of sDMA residues on spliceosomal Sm proteins.

225 Sm ring assembles efficiently in vitro on a spliceosomal Sm site but the engineered U7 snRNP is func

226 he SL for mRNA and an intron that contains a spliceosomal (Sm) binding site.

227 two kinds of RNA--protein complexes (RNPs), spliceosomal small nuclear (sn), and small CB-specific (

228 The initial steps of spliceosomal small nuclear ribonucleoprotein (snRNP) mat

229 Here we show that GEMIN2, a spliceosomal small nuclear ribonucleoprotein assembly fa

230 , which has a well characterized function in spliceosomal small nuclear ribonucleoprotein assembly.

231 SMN is important for the biogenesis of spliceosomal small nuclear ribonucleoprotein particles,

232 mponents of the CB, such as the SMN complex, spliceosomal small nuclear ribonucleoproteins (RNPs), sm

233 erized function of SMN is as an assembler of spliceosomal small nuclear ribonucleoproteins (snRNPs).

234 s in pre-mRNA splicing, forming the cores of spliceosomal small nuclear ribonucleoproteins (snRNPs).

235 plays an essential role in the biogenesis of spliceosomal small nuclear ribonucleoproteins in all tis

236 NF family of proteins found in the U1 and U2 spliceosomal small nuclear ribonucleoproteins is highly

237 protein complex required for the assembly of spliceosomal small nuclear ribonucleoproteins.

238 er RNA (pre-mRNA) splicing requires multiple spliceosomal small nuclear RNA (snRNA) and pre-mRNA rear

239 nesis of eukaryotic ribosomal RNA (rRNA) and spliceosomal small nuclear RNA (snRNA), uridines at spec

240 he long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA).

241 Because spliceosomal small nuclear RNAs (snRNAs) bind the substr

242 y recurrent hotspot mutations (r.3A>G) of U1 spliceosomal small nuclear RNAs (snRNAs) in about 50% of

243 toplasmic injection of fluorescently labeled spliceosomal small nuclear RNAs (snRNAs), target the nas

244 the presence of pseudouridines (Psis) on the spliceosomal small nuclear RNAs (snRNAs), which may enab

245 modification of nucleotides in ribosomal and spliceosomal small nuclear RNAs, respectively.

246 r, binds to trimethylguanosine (TMG) caps on spliceosomal small nuclear RNAs.

247 s important for the biogenesis of ribosomes, spliceosomal small nuclear RNPs, microRNAs and the telom

248 (U1), vertebrates' most abundant non-coding (spliceosomal) small nuclear RNA, silences proximal PASs

249 proteins, with Lsm10 and Lsm11 replacing the spliceosomal SmD1 and SmD2.

250 interactions with the C-terminal tail of the spliceosomal SmN/B/B' proteins in FAS/CD95 alternative s

251 8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) gene

252 the first time that 5FU incorporates into a spliceosomal snRNA at natural pseudouridylation sites in

253 rformed the first high-throughput mapping of spliceosomal snRNA Psis by small RNA Psi-seq.

254 s have now shown that mutations in one minor spliceosomal snRNA, U4atac, are linked to a rare autosom

255 to that typical for eukaryotes, T. vaginalis spliceosomal snRNAs lack a cap and may contain 5' monoph

256 resulted in the coprecipitation of the five spliceosomal snRNAs, core Sm polypeptides, and the U1-sp

257 methylguanosine (TMG) caps characteristic of spliceosomal snRNAs.

258 erogeneous mixture of pre-mRNAs and the five spliceosomal snRNAs.

259 of Cajal bodies (CBs), major NBs involved in spliceosomal snRNP assembly and their role in genome org

260 nuclear RNAs (snRNAs)-and promotes efficient spliceosomal snRNP assembly.

261 SMN protein in orchestrating the assembly of spliceosomal snRNP particles and subsequently regulating

262 This loss of spliceosomal snRNP production results in increased splic

263 Here we present the detailed structure of a spliceosomal snRNP, revealing a hierarchical network of

264 k) physically associates with both dSNUP and spliceosomal snRNPs and localizes to nuclear Cajal bodie

265 In particular, the minor spliceosomal snRNPs are affected, and some U12-dependent

266 ago, the structure, assembly and function of spliceosomal snRNPs have been extensively studied.

267 on exon 7 splicing, demonstrating that core spliceosomal snRNPs influence SMN2 alternative splicing.

268 The five major spliceosomal snRNPs were observed in both complexes by a

269 unique Sm core that differs from that of the spliceosomal snRNPs, and an essential heat labile proces

270 ins effect nuclear localization of the other spliceosomal snRNPs, the Lsm proteins mediate U6 snRNP l

271 he protein is required for the biogenesis of spliceosomal snRNPs, which are essential components of t

272 tate proper cotranscriptional association of spliceosomal snRNPs.

273 c proteins that are crucial to biogenesis of spliceosomal snRNPs.

274 rucial role in the biogenesis of four of the spliceosomal snRNPs.

275 their excision process resembles the nuclear spliceosomal splicing pathway.

276 ingly, the mechanistic basis for restricting spliceosomal splicing to the first transesterification r

277 provide parallels to evolutionarily related spliceosomal splicing.

278 vators promote the formation of PPIs between spliceosomal sub-complexes, whereas repressors mostly op

279 ositive regulators include components of the spliceosomal subcomplex U1 small nuclear ribonucleoprote

280 We find that individual spliceosomal subcomplexes associate with pre-mRNA sequen

281 en the C/D guide RNA and large ribosomal and spliceosomal substrate RNAs.

282 cifically SAP155 and U5-116 kDa, are the key spliceosomal substrates for these phosphatases.

283 ation within a putative RNA binding protein (spliceosomal timekeeper locus1 [STIPL1]) that induces a

284 Spliceosomal twin introns (stwintrons) are introns where

285 lla, Salmonella, and Listeria interfere with spliceosomal U snRNA maturation in the cytosol.

286 n mammals, small multigene families generate spliceosomal U snRNAs that are nearly as abundant as rRN

287 The assembly of spliceosomal U snRNPs depends on the coordinated action

288 The formation of Sm core structures of spliceosomal U-rich small nuclear ribonucleoprotein part

289 II, which in trypanosomes also generates the spliceosomal U-rich small nuclear RNAs.

290 Human spliceosomal U1 small nuclear ribonucleoprotein particle

291 exons by promoting productive docking of the spliceosomal U1 snRNP to a suboptimal 5' splice site.

292 cterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases

293 otide RNA bound to tagged derivatives of the spliceosomal U1A RNA-binding domain.

294 The spliceosomal U4/U6 di-snRNP contains extensively base pa

295 ) genes, which encode core components of the spliceosomal U6 small nuclear ribonucleoprotein complex,

296 and adenosine nucleosides from the 3' end of spliceosomal U6 small nuclear RNA (snRNA), directly cata

297 tions for up to ~160-nt-long RNAs, including spliceosomal U6 small nuclear RNA and a cyclic-di-AMP bi

298 The spliceosomal U6 snRNA is an exception, being stably asso

299 hodiesterase that regulates the stability of spliceosomal U6-RNA.

300 een proposed that defects in the assembly of spliceosomal uridine-rich small nuclear ribonucleoprotei