ライフサイエンスコーパス: splicing event

1 soform-level quantification and differential splicing events).

2 e splice form in plants ( 50% of alternative splicing events).

3 xon skipping, a readily measured alternative splicing event.

4 rmine the functional units that control this splicing event.

5 no evidence for a stop codon or alternative splicing event.

6 f functional protein owing to an alternative splicing event.

7 roximity to either an upstream or downstream splicing event.

8 signed to suppress the oncogenic alternative splicing event.

9 n the mechanism that underlies this aberrant splicing event.

10 ocation and calculate the frequency for each splicing event.

11 on" which must then be excised with a fourth splicing event.

12 afCutter in the context of detecting outlier splicing events.

13 ng relative isoform or exon usage in complex splicing events.

14 malian species used for studying alternative splicing events.

15 6.2% of detected mRNAs displayed alternative splicing events.

16 dvance quantification and discovery of novel splicing events.

17 ealing many previously unknown non-canonical splicing events.

18 rature effects on a large subset of pre-mRNA splicing events.

19 were widespread but rare compared to normal splicing events.

20 reveal hundreds of differential alternative splicing events.

21 ules undergoing multiple distant alternative splicing events.

22 of association between variants and aberrant splicing events.

23 early acquisition of pluripotency-associated splicing events.

24 tions in RNA repair and nonconventional mRNA splicing events.

25 es can be used to reduce unwanted off-target splicing events.

26 s maturation requires two cis- and two trans-splicing events.

27 as a means to control the temporal order of splicing events.

28 croarrays can be used to detect differential splicing events.

29 erase II over introns and co-transcriptional splicing events.

30 on the type and the frequency of alternative splicing events.

31 ets of human internal exons showing selected splicing events.

32 NVs) for several allele-specific alternative splicing events.

33 ntification and visualization of alternative splicing events.

34 ll lack of the prototypical type III latency splicing events.

35 obases, as were intron retention alternative splicing events.

36 ng 84 previously uncharacterized alternative splicing events.

37 periments on eight exon skipping alternative splicing events.

38 of novel exons, and identification of novel splicing events.

39 f considering both annotated and unannotated splicing events.

40 ancer driver pathways with these alternative splicing events.

41 .5%) of circRNAs could be explained by known splicing events.

42 increasingly recognized class of alternative splicing events.

43 ted RNA splicing and an excess of 5' cryptic splicing events.

44 orpholinos lead to unexpected off-target mis-splicing events.

45 P binding sites, especially those related to splicing events.

46 EIDS), for the identification of alternative splicing events.

47 5 co-regulated a large number of alternative splicing events.

48 nes, and induce H3K36me3-coupled alternative splicing events.

49 -life but are not required for most pre-mRNA splicing events.

50 116 transcriptional termination sites and 80 splicing events.

51 sualization approaches can be limiting, with splicing events a challenge to interpret.

52 d Replicate Analysis of Allelic Differential Splicing Events), a method for detecting allele-specific

53 retentions were the most common alternative splicing events, accounting for 33% of all splicing even

54 D1, LSD1n, which results from an alternative splicing event, acquires a new substrate specificity, ta

55 CELF1 by PKC is necessary for regulation of splicing events altered in diabetes.

56 es, but the rules governing and coordinating splicing events among multiple alternate splice sites wi

57 confidence transcripts, perform differential splicing event analysis, and differential isoform analys

58 ich is upregulated in gliomas, controls this splicing event and similarly mediates switching to a lig

59 Twelve splicing events and an unexpectedly large number of anti

60 systematically discover aberrant alternative splicing events and characterize potential associated sp

61 h neurodevelopmentally important alternative splicing events and clinically relevant neuronal transcr

62 and binding activity for six MBNL1-mediated splicing events and found that the splicing activity pro

63 vation of SRSF2 in liver caused dysregulated splicing events and hepatic metabolic disorders, which t

64 rstanding the mechanisms that cause aberrant splicing events and how this leads to disease is vital f

65 plice donor sites was able to abrogate these splicing events and hybrid mRNA formation in Bcl-15 cell

66 isms, for example, detecting alternative RNA splicing events and oncogenic chromosomal rearrangements

67 teins, and strategies to modulate pathologic splicing events and protein-RNA interactions in cancer.

68 Analysis of the splicing events and RNA-Seq based expression profiles re

69 one aberrantly expressed gene, five aberrant splicing events and six mono-allelically expressed rare

70 prioritized lists of results that highlight splicing events and their biological consequences.

71 itate exploration of developmentally altered splicing events and to improve understanding of post-tra

72 tools to discover novel exons, junctions and splicing events and to precisely and sensitively assess

73 ads to define gene structure and alternative splicing events and to quantify transcript abundance alo

74 ed the likely causal SNP for the alternative splicing event, and at one, functionally validated the e

75 e splicing events, accounting for 33% of all splicing events, and 43% of the events in coding regions

76 rofiled gene expression changes, alternative splicing events, and DNA methylation patterns during nod

77 which offers high sensitivity for detecting splicing events, and its application to the unicellular

78 known and novel high-confidence alternative splicing events, and to integrate them with both protein

79 tify variants that correlate with unexpected splicing events, and to measure the splice-modulating po

80 also identified a number of MuLV alternative splicing events, and we uncovered evidence of APOBEC3G (

81 ds of gene models; (iii) propose alternative splicing events; and (iv) predict 5' and 3' untranslated

82 Splicing events antisense to gene models were also detec

83 These non-canonical splicing events are a major source of newly emerging tra

84 the rgh3 mutant, a fraction of noncanonical splicing events are altered.

85 nd that a significant number of AR-regulated splicing events are associated with tumor progression.

86 Understanding how splicing events are coordinated across numerous introns

87 ional probability-based models, we show that splicing events are coordinated across these sites.

88 25% of T-cell receptor-mediated alternative splicing events are dependent on JNK signaling.

89 lyses further indicated that the alternative splicing events are important for target gene expression

90 ctions of most species- and lineage-specific splicing events are not known.

91 hich most non-mutually exclusive alternative splicing events are randomly combined into individual mR

92 t approximately a quarter of the IAV-induced splicing events are regulated by hnRNP K, a host protein

93 erent genomic rearrangements and alternative splicing events around the junction region lead to multi

94 omputationally expensive, focusing on single splicing events as a proxy for transcriptome characteris

95 dentify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressivenes

96 e-wide characterization of intraerythrocytic splicing events, as captured by RNA-Seq data from four t

97 This has identified disease-relevant splicing events, as well as associations between splicin

98 this study, we sought to analyze alternative splicing events (ASE) that could alter gene function ind

99 A discrete set of alternative splicing events (ASEs) are shared between MBNL1-low canc

100 is altered in tumours, leading to oncogenic splicing events associated with tumour progression and a

101 pper TopHat, including a novel nonproductive splicing event at the gp350/gp220 locus and several alte

102 ring and quantifying circular and linear RNA splicing events at both annotated and un-annotated exon

103 s), an R package for visualising alternative splicing events at single-cell resolution.

104 Combinatorial alternative splicing events at the 5' end of the gene allow for the

105 he gp350/gp220 locus and several alternative splicing events at the LMP2 locus.

106 gnificant frequency, and whether alternative splicing events at these sites are independent of each o

107 e splicing and identifying the difference in splicing events between diseased and healthy tissue is c

108 We identified 593 differential alternative splicing events between HD and control brains.

109 recent discoveries of trans-splicing and cis-splicing events between neighboring genes suggest that t

110 We also identify tens of thousands of novel splicing events beyond those previously annotated by the

111 SSO not only accurately identified canonical splicing events, but also pinpointed novel, but rare, ex

112 merase) is subjected to numerous alternative splicing events, but the regulation and function of thes

113 id (ABA) is shown to mediate the alternative splicing event by reducing the functional Isoform1 and i

114 sically couples transcription elongation and splicing events by interacting with splicing factors thr

115 nds (RACE) experiments and findings of novel splicing events by RNA-seq suggest that the complexity o

116 HnRNP A1 regulates many alternative splicing events by the recognition of splicing silencer

117 pharmacological manipulation of a single key splicing event can manifest powerful antitumorigenic pro

118 enes are alternatively spliced, and aberrant splicing events can cause disease.

119 matically targeting thousands of alternative splicing events, CHyMErA identifies exons underlying hum

120 how these splicing factors regulate pre-mRNA splicing events, comparatively little is known about the

121 s of endogenous TDP-43-dependent alternative splicing events conferred by both human wild-type and mu

122 Ldo45 is the product of a splicing event connecting two adjacent genes (YMR147W an

123 nated and biologically important alternative splicing events continue to be discovered in an ever-inc

124 in C. elegans is regulated by an alternative splicing event controlled by the SR protein kinase SPK-1

125 A minimum of 10 splicing events (Delta1Aq, Delta5, Delta5q, Delta8p, Del

126 Indeed, transcriptome-wide analysis of splicing events demonstrated that RBM25 regulates a larg

127 ference genome and a catalog of all possible splicing events developed from the genome, thereby provi

128 Alternative splicing events differentially regulated between tissues

129 gy to identify approximately 700 alternative splicing events directly regulated by the neuron-specifi

130 Unfortunately, aberrant splicing events do occur which have been linked to genet

131 s reported to be the most common alternative splicing event due to loss of functional domains/sites o

132 that CELF2 controls a similar proportion of splicing events during human thymic T-cell development.

133 d intron to be the most abundant alternative splicing events during lens development.

134 vestigate the transcriptomic alterations and splicing events during mouse lens formation using RNA-se

135 We propose a working model of the unique splicing event enhanced by the mutation, as well as puta

136 ons and 2301 differentially used alternative splicing events, enriched in genes involved in regulator

137 analysis of other major types of alternative splicing events, especially for retained intron events s

138 This splicing event establishes a selectivity filter to restr

139 ifferent exons, making it possible to detect splicing events even when sequencing depth is low.

140 In the splicing events examined previously, Hu proteins promote

141 ulation of hundreds of transcripts and their splicing events exclusively by mCpH levels, independentl

142 ctionally distinct classes of MBNL1-mediated splicing events exist as defined by requirements for ZF-

143 native splicing of timeless (tim), promoting splicing events favored at warm temperature over those i

144 uence complementarity, and identified 17 mis-splicing events for one of the ASOs tested.

145 nscripts are most commonly generated by back-splicing events from exons of protein-coding genes.

146 LeafCutter identifies variable splicing events from short-read RNA-seq data and finds e

147 We present VALERIE (Visualising alternative splicing events from single-cell ribonucleic acid-sequen

148 promising to uncover many novel alternative splicing events, gene fusions and other variations in RN

149 nd abundance of proteasome-catalyzed peptide splicing events has implications for immunobiology and a

150 oding RNAs generated from non-canonical back-splicing events, have emerged to play key roles in many

151 Because the most common type of splicing event identified was an alternative start site

152 actor regulating a wide range of alternative splicing events implicated in neuronal development and m

153 RBFOX1 regulates a wide range of alternative splicing events implicated in neuronal development and m

154 genes also identified additional alternative splicing events implicated in tumorigenesis.

155 rs of phylogenetically-conserved alternative splicing events important for muscle function.

156 hich is the least understood RNA alternative splicing event in mammalian cells.

157 act of structural changes and an alternative splicing event in MDR49 on DDT-resistance in 91-R, as co

158 An alternative splicing event in the 5' untranslated region allows for

159 le Trachemys scripta elegans, an intraexonic splicing event in the brain-derived neurotrophic factor

160 ariants demonstrated a key role for this RNA splicing event in the resistance of cells to anoikis.

161 Minigene splicing assays revealed a novel splicing event in which insertion of two additional repe

162 s including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLI

163 We reveal 14,353 alternative splicing events in 17,669 novel isoforms at different st

164 We identified 405 splicing events in 323 genes that are significantly affe

165 NA sequencing data identifies non-productive splicing events in 7,757 protein-coding human genes, of

166 A growing body of work has implicated mis-splicing events in a range of diseases, including cancer

167 total of 2323 genes that undergo alternative splicing events in at least one nodule developmental sta

168 inhibition of some, but not all, endogenous splicing events in cells, as previously reported for the

169 for label-free quantification of alternative splicing events in complex samples.

170 Importantly, we uncover dozens of splicing events in cultured T cells whose changes upon s

171 put data (RNA-seq data) to study alternative splicing events in different types of cells.

172 a sensitive algorithm to detect alternative splicing events in each cell type.

173 l initiation and elongation, and alternative splicing events in ES cells.

174 asets show a preponderance of 3' alternative splicing events in fam50a KO, suggesting a role in the s

175 ELAV, which regulate overlapping networks of splicing events in GABAergic and cholinergic neurons.

176 hment analyses found a substantial number of splicing events in genes related to RNA metabolism.

177 By global profiling of the SRSF3-regulated splicing events in human osteosarcoma U2OS cells, we fou

178 e used the algorithm to profile differential splicing events in lung adenocarcinoma A549 cells after

179 contribute to a subset of S34F-dysregulated splicing events in MDS patients.

180 on of intron retention being the most common splicing events in nodules compared to roots.

181 nd coupling of specific 5' ends with 3' mRNA splicing events in postmortem human brain and human stem

182 sor for label-free monitoring of alternative splicing events in real-time, without any cDNA synthesis

183 An improved understanding of alternative splicing events in RMS cells will potentially reveal nov

184 ncing to generate a comprehensive profile of splicing events in Schizosaccharomyces pombe, amongst th

185 ng the activity of PSF toward a broad set of splicing events in T cells.

186 1a-driven transcriptomes feature alternative splicing events in the 5'-untranslated region (5'-UTR) t

187 NA-seq methods to identify known alternative splicing events in the Drosophila sex determination path

188 of retained intronic HOX sequences and lost splicing events in the HOX cluster are observed in cells

189 e investigated the role of SMN-dependent U12 splicing events in the regulation of motor circuit activ

190 latory proteins, and/or specific key altered splicing events in the treatment of cancer.

191 nd sites, as well as hundreds of alternative splicing events in these B1a cells.

192 Alkbh5 has effects on m(6)A density and splicing events in tumors during ICB.

193 By analyzing genome-wide DNA splicing events in two micronuclear genomes of Oxytricha

194 ic insight into SRSF10-regulated alternative splicing events in vivo and demonstrate that SRSF10 play

195 A proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known

196 ific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance ep

197 luding insertions, deletions and alternative splicing events, in protein-small molecule affinity, unr

198 haracterized a total of 63 BRCA1 alternative splicing events, including 35 novel findings.

199 e analysis identified a group of alternative splicing events, including the splicing of small introns

200 dicates numerous gene expression and RNA mis-splicing events, including transcription factors from th

201 he 3' region of NOTCH1, which cause aberrant splicing events, increase NOTCH1 activity and result in

202 a short direct repeat-mediated noncanonical splicing event induced by dexamethasone, which leads to

203 decreases the expression of HIV-1 and alters splicing events involved in the production of HIV-1 mRNA

204 to gain mechanistic insight into alternative splicing events involving exons 2 and 16 (E2 and E16) th

205 s of the Arabidopsis JAZ family, alternative splicing events involving retention of this intron gener

206 thought that most canonical or non-canonical splicing events involving U2- and U12 spliceosomes occur

207 Each alternative splicing event is controlled by multiple RBPs, the combi

208 Although the splicing event is highly conserved, one splice variant h

209 Previously, we reported that this splicing event is highly dysregulated in aggressive form

210 Moreover, this splicing event is itself dependent on JNK signaling.

211 Although this alternative splicing event is likely regulated by multiple splicing

212 tex1 plants the ratio of certain alternative splicing events is altered.

213 , software specific for the detection of DNA splicing events is scarce.

214 We suggest RSF, a tool for identifying novel splicing events, is applicable to study a range of disea

215 in the SORT1 mRNA, a pathologically relevant splicing event known to be regulated by TDP-43, is also

216 cis-elements surrounding a given alternative splicing event lead to an integrated splicing decision.

217 s targeting multiple types of non-productive splicing events lead to increases in productive mRNA and

218 nstream) of the introns regulate alternative splicing events, likely through modulating accessibility

219 factor network interactions and alternative splicing events, little of which can be resolved by long

220 We found that SRSF2 (P95H) misregulates 548 splicing events (<1% of total).

221 Other regulated splicing events may determine how an mRNA is utilized in

222 nylated downstream mRNA, and that this trans-splicing event negatively impacts the biogenesis of matu

223 ha1 and -alpha4, we could validate, in vivo, splicing events observed in in vitro studies.

224 These splicing events occur exclusively in trigeminal ganglia,

225 iversity of protein functions, and alternate splicing events occur in tumors.

226 mical changes in splicing, with differential splicing events occurring more frequently in early devel

227 Moreover, we showed that the alternative splicing event of FGFR2 is associated with virus infecti

228 early in the plant lineage by an alternative-splicing event of the pre-mRNA encoding the chloroplast

229 ls that NOVA2 uniquely regulates alternative splicing events of a series of axon guidance related gen

230 volve the distinct alteration of alternative splicing events of specific transcription factors contro

231 monstrated dysregulated splicing for ~25% of splicing events, of which genes themselves involved in m

232 enes, with significantly increased levels of splicing events, particularly those predicted to have su

233 of cap-associated transcription start sites, splicing events, poly(A) site choice and poly(A) tail le

234 RNA-Seq evidence, (ii) identify alternative splicing events present in the augmented annotation grap

235 n3 is a regulator of hundreds of alternative splicing events, principally acting as a splicing repres

236 splice sites caused the majority of aberrant splicing events, providing a strategy for recoding lenti

237 ess in vivo can be attributed to alternative splicing events regulated at the level of individual neu

238 sed RNA interference and RNA-seq to identify splicing events regulated by 56 Drosophila proteins, som

239 Using mRNA-seq, we identify endogenous splicing events regulated by DAZAP1, many of which are i

240 We also report thousands of alternative splicing events regulated by genetic variants.

241 nctional at the molecular level and improved splicing events regulated by MBNLs in all disease models

242 In the RNA-Seq analysis of alternative splicing events regulated by the epithelial-specific spl

243 ovel analytical tool, we have identified new splicing events regulated by the oncogenic splicing fact

244 k flow for the identification of alternative splicing events relying on the established linear mixed

245 However, the mechanisms regulating this splicing event remain unclear.

246 However, the SRSF3-regulated splicing events responsible for its oncogenic activities

247 TP53 undergoes multiple RNA-splicing events, resulting in at least nine mRNA transcr

248 This alternative splicing event results in the formation of RNA processin

249 Splicing events retain noncatalytic domains while ablati

250 dissection of mutually exclusive alternative splicing events revealed that U2AF1 isoforms' inherent d

251 by either fusion genes (DNA level) or trans-splicing events (RNA level).

252 RASL-Seq to identify approximately 40 T cell splicing events sensitive to PSF knockdown, and show tha

253 Analysis of back-splicing events showed widespread RNA circularization, w

254 focused upon modulating the SMN2 alternative splicing event since this would produce more wild-type p

255 focused only on the most common alternative splicing event, skipped exon or exon skipping.

256 yses for all five major types of alternative splicing events: skipped exon, mutually exclusive exons,

257 st partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzymatic activit

258 e deaminase) showed differential alternative splicing events, suggesting that specific changes in the

259 lignments revealed 1,908 high-confidence new splicing events supported by 10 or more spliced read ali

260 Our analyses also revealed multiple novel splicing events supported by more reads than previously

261 etase catalytic nulls created by alternative splicing events that ablate active sites, here a non-spl

262 We identified many alternative splicing events that are regulated by multiple splicing

263 strategy could be employed to modulate other splicing events that are regulated by RNA secondary stru

264 stigate the complete spectrum of alternative splicing events that are regulated by the epithelium-spe

265 ad but low frequency alternative or aberrant splicing events that are targeted by nuclear RNA surveil

266 s of controlling the cascade of sex-specific splicing events that controls sexual differentiation in

267 We also suggest specific splicing events that could be implicated in autoregulato

268 plicing by promoting two intricately coupled splicing events that ensure selection of a weak distal a

269 and together they regulate many alternative splicing events that favors expression of protein isofor

270 icing or polyadenylation factors, leading to splicing events that generate promigratory isoforms.

271 Here, we review the functions of alternative splicing events that have been experimentally determined

272 ibility to identify differential alternative splicing events that match a given user-defined pattern.

273 ion to control the balance and complexity of splicing events that regulate viral oncoprotein expressi

274 First, we improved the splicing events that remove the gamma-globin intron by o

275 encing we identified a set of 22 alternative splicing events that undergo a developmental switch in s

276 nscriptional gene regulation and alternative splicing, events that are restricted to the cell nucleus

277 hat undergo a mutually exclusive alternative splicing event to generate multiple functionally-distinc

278 is largest assemblage of new and alternative splicing events to date in Plasmodium falciparum provide

279 wn that Mcl-1 pre-mRNA undergoes alternative splicing events to produce two functionally distinct pro

280 anscript analysis links multiple alternative splicing events together and allows for better estimates

281 molecules designed to alter these and other splicing events typically target continuous linear seque

282 splice site choice at exon 2 (E2) via nested splicing events, ultimately modulating expression of N-t

283 ap can identify major classes of alternative splicing events under a single cellular condition, witho

284 hlet mixture model and discovers alternative splicing events using a new graph modular decomposition

285 omic region, corresponding to an alternative splicing event, VALERIE generates an ensemble of informa

286 hat the breast cancer risk and the alternate splicing event were due to the same causal SNP.

287 Four different types of splicing events were affected by dnmt3 gene knockdown, a

288 disease-associated proteins) and 965 altered splicing events were detected (including in sortilin, th

289 In addition, 310 alternative splicing events were detected in 254 (4.5%) genes, most

290 After induction, hundreds of candidate splicing events were detected using the junction mapper

291 Novel splicing events were found in members of some gene famil

292 Novel SLE associated splicing events were identified in the T-reg restricted

293 Over 200 previously unannotated splicing events were identified, including examples of r

294 Half of the splicing events were regulated by multiple proteins, dem

295 ghly regulated and accurate, it leads to mis-splicing events, which may result in proteins with alter

296 equencing junction expression identified 109 splicing events, which were confirmed in a validation se

297 This analysis identified several hundred splicing events whose regulation depended on Mbnl functi

298 ccuracy and could detect up to twice as many splicing events with precision similar to the best refer

299 datasets, SCATS identified more differential splicing events with subtle difference across cell types

300 mosquitoes revealed evidences of alternative splicing events with three transcripts of 2092, 2061 and