ライフサイエンスコーパス: sporadic

1 ly 10% of ALS cases are familial and 90% are sporadic.

2 All patients were Caucasian and half were sporadic.

3 more common in familial (17/20, 85%) than in sporadic (10/22, 45%) pedigrees (P=0.007).

4 sing 462 essential tremor (ET) subjects (285 sporadic, 125 with family history, and 52 probands from

5 eration and that targeting STING may prevent sporadic AAD development.

6 of this mechanism in aortic degeneration and sporadic AAD formation.

7 in Sting-deficient (Sting(gt/gt)) mice in a sporadic AAD model induced by challenging mice with a co

8 In the sporadic AAD model, Sting(gt/gt) mice showed significant

9 In human sporadic AAD tissues, we observed the presence of cytoso

10 osis (LCH) is a myeloid neoplasia, driven by sporadic activating mutations in the MAPK pathway.

11 rental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of E

12 rphism in brain tissue from individuals with sporadic AD (s-AD) and CU-AP.

13 due to familial AD (FAD); ~98% of cases are sporadic AD (SAD).

14 u, Nf-L, and GFAP predict the development of sporadic AD and cognitive decline, and changes in struct

15 poE4) is the largest genetic risk factor for sporadic AD and contributes to AD pathogenesis by influe

16 rupt lysosomal function in DS is relevant to sporadic AD where APP-betaCTF, but not APP, is also elev

17 omal-lysosomal pathobiology emerges early in sporadic AD, where neuronal APP-betaCTF is also elevated

18 NA changes as a presymptomatic indication of sporadic AD.

19 plaques of cases with autosomal dominant and sporadic AD.

20 ts, as well as subjects with familial AD and sporadic AD.

21 a therapeutic target for diabetic-associated sporadic AD.SIGNIFICANCE STATEMENT More than 95% of the

22 age-related hearing loss (mARHL) and simplex/sporadic age-related hearing loss (sARHL) cases and cont

23 ease, genomic investigations of familial and sporadic ALL have revealed a growing number of genetic a

24 ause these organs are only described through sporadic allusions in the literature, this review aims t

25 23 participants with sporadic ALS and 23 healthy controls underwent diffusion

26 nce between the mean age of onset in genetic sporadic ALS and familial ALS (p=0.097).

27 g platform that recapitulates key aspects of sporadic ALS and uncovers both an initial neuroprotectiv

28 ECM and cell adhesion genes occurs in C9 and sporadic ALS but not SOD1-ALS.

29 pinal motor neurons dissected from C9-ALS or sporadic ALS patients were highly concordant with each o

30 d several-fold in the spinal cord GM of male sporadic ALS patients.

31 C-derived motor neurons to serially passaged sporadic ALS post-mortem tissue (spALS) extracts.

32 ~10% of cases, leaving the remaining 90% of sporadic ALS relatively understudied.

33 d associations between mutations in UGT8 and sporadic ALS, and between ST6GAL1 mutations and conversi

34 t 5 years younger than those with apparently sporadic ALS, and we have shown that this is a result of

35 o model early cell type-specific features of sporadic ALS.

36 S has a younger age of onset than apparently sporadic ALS.

37 ys predicted to be involved in C9 as well as sporadic ALS/FTD etiology, including the proteasomal and

38 ts have been observed to correlate in C9 and sporadic ALS/FTD patients alike, suggesting that changes

39 ature compared with samples from people with sporadic ALS/FTD; this increased interferon response can

40 fibrillary acidic protein (GFAP) with common sporadic Alzheimer disease (AD) and cognitive decline is

41 EAAT2 expression is reduced in aging and sporadic Alzheimer's disease (AD) patients' brains.

42 Maternal history for sporadic Alzheimer's disease (AD) predisposes the offspr

43 r 100 years ago, the molecular foundation of sporadic Alzheimer's disease (AD) remains elusive.

44 Variations in many genes linked to sporadic Alzheimer's disease (AD) show abundant expressi

45 unmet need for presymptomatic biomarkers of sporadic Alzheimer's disease (AD), we leveraged the rece

46 xhibited more pronounced motor symptoms than sporadic Alzheimer's disease patients with the same Clin

47 au PET binding overlapped with those seen in sporadic Alzheimer's disease, but with a greater cortica

48 ta (measured using identical procedures) for sporadic Alzheimer's disease, familial Alzheimer's disea

49 ible lineages emerged earlier, but showcased sporadic AMR determinant acquisition largely after 1960,

50 gregated transthyretin causes hereditary and sporadic amyloidoses.

51 hree independent cohorts of individuals with sporadic amyotrophic lateral sclerosis (ALS).

52 For instance, the majority of patients with sporadic amyotrophic lateral sclerosis (up to 97%) and a

53 ated by the use of cells from a patient with sporadic amyotrophic lateral sclerosis but can be applie

54 reening approach identified that C9orf72 and sporadic amyotrophic lateral sclerosis induced astrocyte

55 We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases.

56 In the preclinical phase of both sporadic and autosomal dominant AD, multiple behavioral

57 The similarities with sporadic and autosomal dominant Alzheimer's disease and

58 bipartite genome of Vibrio cholerae harbors sporadic and conserved MGEs that contribute in the disea

59 ariants in the Tbk1 gene associate with both sporadic and familial amyotrophic lateral sclerosis (ALS

60 e human thrombopoietin receptor (TpoR) drive sporadic and familial essential thrombocythemias (ETs).

61 LRRK2 has been associated with sporadic and familial forms of Parkinson's disease, and

62 c neurodegenerative pathway relevant to both sporadic and familial forms Parkinson's disease.

63 Mitochondrial dysfunction is implicated in sporadic and familial Parkinson's disease (PD).

64 chanism leading to neurodegeneration in both sporadic and familial PD upon parkin loss-of-function re

65 ically reduced mitophagy are evident in both sporadic and familial PD.

66 e review known genetic contributions to both sporadic and familial pneumothorax.

67 stages of an epidemic, infections are often sporadic and geographically distributed.

68 The modern distribution of H4a1 is rare and sporadic and has been identified in areas including the

69 cine encoding many neoantigens shared across sporadic and hereditary MSI tumors.

70 s are amyloidogenic and cause, respectively, sporadic and hereditary systemic TTR amyloidosis.

71 s involved in spontaneous prion formation in sporadic and inherited human prion diseases or equivalen

72 RC1/2 and EPH receptor-mediated signaling in sporadic and NF2-associated VS.

73 cases of congenital heart disease (CHD) are sporadic and nonsyndromic, with poorly understood etiolo

74 ations and gene expression changes have been sporadic and nonsystematic.

75 ymphoma with three classifications: endemic, sporadic, and immunodeficiency-related.

76 Outbreaks are sporadic, and the influence of viral dynamics in bats on

77 Most of the cases of PDS in our study were sporadic, and the risk to first-degree relatives is lowe

78 ese gains will be opportunistic, uneven, and sporadic, and they will suffer from the law of diminishi

79 ely susceptible to antimicrobials but showed sporadic antimicrobial resistance (AMR) gene acquisition

80 Sporadic aortic aneurysm and dissection (AAD), caused by

81 e majority of familial and in almost half of sporadic ARVC.

82 xamined in aortic tissues from patients with sporadic ascending thoracic AAD.

83 Consequently, a watch-and-wait policy for sporadic asymptomatic cPanNENs <=2 cm seems justified an

84 Transgene brain expression was sporadic at the cellular level and most prominent in hip

85 P was asymptomatic in 2 patients; 2 reported sporadic attacks; and 1 reported recurrent attacks (>4 a

86 tumour initiation in two different models of sporadic, autochthonous tumorigenesis.

87 DAI causes immediate, sporadic axon damage followed by progressive secondary a

88 Drivers of sporadic benign pituitary adenoma growth are largely unk

89 thirty-four patients (46% men) with single, sporadic, biopsy-proven RCC (median size +/- standard de

90 (2006-2013), study participants with single, sporadic, biopsy-proven RCC were included to calculate t

91 ermine the frequency of the R337H variant in sporadic breast cancer patients from Parana state, South

92 ion of the BRCA1 gene in both hereditary and sporadic breast cancers, and other BRCA1-associated canc

93 of steady accumulation in the parenchyma and sporadic bursts of tracer leakage.

94 in living cells, and transcription occurs in sporadic bursts, but how these phenomena are related is

95 Occurrence is mostly sporadic, but rare family clusters have been described.

96 MAYV emergence is typically sporadic, but recent isolations and outbreaks indicate t

97 hese disorders because, unlike patients with sporadic cancer, these patients require specialised life

98 ibromatosis type 2 (NF2), as well as various sporadic cancers including kidney cancer.

99 gical processes pertinent to the more common sporadic cancers.

100 molecular agents to treat both inherited and sporadic cancers.

101 n ribosome biogenesis may also be drivers in sporadic cancers.

102 tegrity of the major tumor suppressor p53 in sporadic cancers.

103 for studies reporting norovirus outbreak or sporadic case genotypes and merged this with data on pro

104 Most sporadic cases (74.9%) and reported outbreaks (86.8%) oc

105 seasonal and genotypic associations between sporadic cases and outbreaks are suggestive of contempor

106 Yersinia pestis continues to cause sporadic cases and outbreaks of plague worldwide and is

107 Among both sporadic cases and outbreaks, GII genogroup noroviruses

108 Among both sporadic cases and outbreaks, GII genogroup noroviruses

109 Of the total burden, sporadic cases constituted >90% (thus, annual burden may

110 of NIID varies widely, and both familial and sporadic cases have been reported.

111 in aggregates first arise in the majority of sporadic cases have remained unclear.

112 In 2010, sporadic cases of avian leukosis virus (ALV)-like bursal

113 ypes of IAVs can infect swine; however, only sporadic cases of infection with avian IAVs are reported

114 ients with telomerase mutations but also for sporadic cases of IPF associated with physiological agin

115 Rare sporadic cases of meningococcal urogenital and anorectal

116 We investigated the predictive value of sporadic cases on outbreaks using a 2-state discrete Mar

117 We investigated the predictive value of sporadic cases on outbreaks using a two-state discrete M

118 This should also be considered in sporadic cases since adequate family evaluation may not

119 l suggested that the 3-day moving average of sporadic cases was positively associated with the probab

120 Sporadic cases were ascertained via the New Vaccine Surv

121 ly in presence of atypical phenotypes and/or sporadic cases with all healthy relatives is not possibl

122 roteins aggregating in ALS/FTD, including in sporadic cases, are also targeted by autophagy and affec

123 Intermittent sporadic cases, community clusters, and nosocomial outbr

124 sense variants in TLN1 were identified in 10 sporadic cases.

125 ning of genes carrying XL and AD variants in sporadic cases.

126 ons with large effect contributed to ~22% of sporadic CH cases.

127 ism of a significant number of patients with sporadic CH.

128 e its autoactivation and cause hereditary or sporadic chronic pancreatitis.

129 Four of 31 VV-2 type sporadic CJD and 7 of 30 genetic CJD cases showed vagal

130 diverse deposition of PrP(Sc) in genetic and sporadic CJD argues against uniform mechanisms of propag

131 nd identification of disease subtype also in sporadic CJD.

132 Sporadic colon tumorigenesis was assessed in neutrophil-

133 ve the world's highest recorded incidence of sporadic colorectal cancer (CRC) (~91:100,000), whereas

134 lenced in a clinically important subgroup of sporadic colorectal cancers.

135 The genetic architecture of sporadic congenital heart disease (CHD) is characterized

136 We reveal sporadic contacts between Iberia and North Africa by ~25

137 n colonic mucosal tissues from patients with sporadic CRC colonized with vs without CoPEC by quantita

138 microbiome contribute to the development of sporadic CRC or result from it.

139 Sporadic Creutzfeldt-Jakob disease (sCJD) comprises seve

140 Sporadic Creutzfeldt-Jakob disease (sCJD) presents as a

141 We report a detailed study of a cohort of sporadic Creutzfeldt-Jakob disease (sCJD) VV1-2 type-mix

142 egenerative disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD).

143 Its appearance can mimic sporadic Creutzfeldt-Jakob disease on MRI and should be

144 er and a better overall survival compared to sporadic, Crohn- and hereditary syndrome-related SBA.

145 ase-control study examining risk factors for sporadic cryptosporidiosis in the Netherlands.

146 with genotyping to identify risk factors for sporadic cryptosporidiosis.

147 carriers and in non-carrier controls, and in sporadic DCIS.

148 pathogenic variant of whom 36% (n=27/74) had sporadic DCM, whereas 60% (21/35) were familial cases.

149 Here we report a sporadic de novo EGR2 variant, c.1232A > G (NM_000399.5)

150 e neurodevelopmental disorders are caused by sporadic de novo variants.

151 uscular dystrophy (FSHD) is characterized by sporadic de-repression of the transcription factor DUX4

152 postmortem brain tissues from patients with sporadic deep ICH.

153 SMC loss in brain tissues from patients with sporadic deep ICH.

154 Not surprisingly, inherited or sporadic defects in DNA repair mechanisms can give rise

155 the embryonic brain from the consequences of sporadic delamination errors and teratogenic insults.

156 n near the BACE1-cleavage site protects from sporadic dementia, emphasizing APP's role in dementia pa

157 Despite the sporadic detection of fluoroquinolone-resistant Shigella

158 Sporadic detection of natural cases in animals alongside

159 including antibiotic-associated diarrhea and sporadic diarrhea.

160 riant identified in a pediatric patient with sporadic dilated cardiomyopathy, and we determined a mol

161 e of alpha-syn aggregates in the cortices of sporadic disease cases emphasizes the need to understand

162 structural variant mutagenesis mechanisms in sporadic disease traits, emphasize the importance of cop

163 Despite being a sporadic disease, it caused a large outbreak in 2014-201

164 reater representation of older patients with sporadic disease, mild phenotypes, and genotype-negative

165 anaplasia, and also with both unilateral and sporadic disease.

166 ve larger effect sizes than those underlying sporadic diseases.

167 d organ dysfunction in diverse inherited and sporadic diseases.

168 rring mutations) are a pre-dominant cause of sporadic dominant monogenic diseases and play a signific

169 Yet, how sporadic DUX4 expression leads to the generalized muscle

170 cific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well th

171 After 6 months of extremely low sporadic DUX4 expression, dystrophic muscle presented ha

172 spectrum of familial Parkinson's disease and sporadic early-onset Parkinson's disease (sEOPD) in a ma

173 ially fatal form of pneumonia that occurs as sporadic epidemics.

174 hogenic NOTCH2NLC GGC repeat expansions in 4 sporadic ET patients.

175 GGC repeat expansions can be associated with sporadic ET.

176 quence mutations, while one-third are likely sporadic events that occur post-zygotically.

177 c repertoire reveals a highly heterogeneous, sporadic expression pattern unexplained by measurement n

178 als (APs), a train of APs in L1 neurons, and sporadic firing in L2 neurons.

179 RA features sporadic 'flares' or inflammatory episodes-mostly occurr

180 disease, and variants increase risk for the sporadic form of the disease.

181 n (APP) is associated with both familial and sporadic forms of Alzheimer's disease.

182 een typical CADASIL, a genetic form, and two sporadic forms of SVCI (with NOTCH3 and without NOTCH3 v

183 es (NoVs) are the main cause of epidemic and sporadic gastroenteritis.

184 laboratory testing need to be considered, as sporadic, genetic, and acquired forms of prion disease h

185 ps in NF1 patients and the similarities with sporadic glioma remain unknown.

186 Sporadic gliomas in companion dogs provide a window on t

187 tely lead to the development of familial and sporadic haematological malignancies, including acute ly

188 d in an additional cohort of 167 familial or sporadic HMN/CMT2 patients using next-generation sequenc

189 A panel of sporadic human BCCs showed increased staining of both Ds

190 shown to be progressively down-regulated in sporadic human CRC, and its downregulation correlates wi

191 avian influenza A viruses (IAVs) have caused sporadic human infections and enzootic outbreaks among s

192 statistically robust genetic associations in sporadic human prion disease that implicate intracellula

193 n collagen IV variants are a risk factor for sporadic ICH.

194 g disease (ILD), the risk among relatives of sporadic idiopathic pulmonary fibrosis (IPF) is not know

195 imiting our knowledge of the contribution of sporadic illness to the overall impact on reported outbr

196 Sporadic illnesses in the community (incidence, 10-150/1

197 Using a new mouse model that enables sporadic inactivation of the IL-22 receptor in colon epi

198 It often occurs via sporadic inception of spatially localized patches (spots

199 Sporadic incidence precludes evaluation of antimicrobial

200 sible for moderate to severe hearing loss in sporadic individuals born to consanguineous couples.

201 giene within households could prevent future sporadic infections.

202 relatives of patients with both familial and sporadic IPF appear to be at similar risk.

203 relatives with FPF and the 59 relatives with sporadic IPF.

204 ILD among relatives of patients with FPF and sporadic IPF.Methods: Undiagnosed first-degree relatives

205 dentify C. jejuni outbreaks and separate out sporadic isolates during outbreak investigations.

206 Sporadic late-onset Alzheimer disease (LOAD) preceded by

207 f exploration that implicate causal genes in sporadic late-onset Alzheimer's disease (LOAD) pathogene

208 han 95% of the Alzheimer's patients have the sporadic late-onset form (LOAD).

209 tau PET was acquired on 17 older adults with sporadic, late onset Alzheimer disease.

210 everal countries in the world and has caused sporadic lethal infections in humans.

211 cted a probabilistic causal network model of sporadic LOAD and identified TYROBP/DAP12, encoding a mi

212 slow, arrest, or prevent the development of sporadic LOAD.

213 We used the sporadic, low-level, muscle-specific expression of DUX4

214 but data supporting whether this is true for sporadic medically-attended AGE are limited.

215 ltiple endocrine neoplasia type 2 as well as sporadic medullary thyroid cancer.

216 P = 3.2 x 10(-8), odds ratio (OR) = 1.4) for sporadic miscarriage in our European ancestry meta-analy

217 054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for

218 -H colorectal carcinoma were associated with sporadic MLH1ph rather than with Lynch syndrome, and the

219 ce imaging (MEMRI) and immune profiling of a sporadic mouse model of SHH-MB, we found the density of

220 uenza virus showed increases in frequency of sporadic mutations in the PB2, PA, and NA segments.

221 Given the sporadic nature of henipavirus outbreaks, licensure of v

222 zootics in bat populations contribute to the sporadic nature of NiV outbreaks in South Asia.

223 Due to the sporadic nature of outbreaks and the low number of pneum

224 Given the sporadic nature of outbreaks, vaccines provide the best

225 sible due to obvious ethical reasons and the sporadic nature of outbreaks.

226 gregation resemble the cellular pathology of sporadic neurodegenerative diseases (NDs) and how this c

227 sequencing of 381 patients (232 trios) with sporadic, neurosurgically treated CH, we found that dama

228 riants have been found to affect the risk of sporadic, nonsyndromic CHD, but individual studies to da

229 Peak sporadic norovirus activity was often contemporaneous wi

230 2012 and June 2016, there were 755 pediatric sporadic norovirus cases and 45 reported outbreaks.

231 2 families with NIPAL1 mutations and in 197 sporadic NPC cases and 237 controls.

232 in serum magnesium levels was observed among sporadic NPC cases compared to controls (7.1% NPC/1.7% c

233 nts in distal tissues is challenged by their sporadic occurrence in obscure and inaccessible location

234 However, the sporadic occurrence of NTTB isolates reinforces the view

235 The sporadic occurrences of diosgenin in distantly related p

236 elated families with individuals affected by sporadic or dominant HMN/CMT2.

237 nts in the TBK1 gene associate with or cause sporadic or familial amyotrophic lateral sclerosis (ALS)

238 enced 662 whole exomes from individuals with sporadic or familial FSGS.

239 vo studies to address mechanisms influencing sporadic or inflammation-driven tumor development, inclu

240 rsonnel with the NM phenotype, compared with sporadic or no production in those with the IM or PM phe

241 Consequently, in sporadic (or non-familial) PID genetic diagnosis is diff

242 tes in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 pati

243 erican countries where it is responsible for sporadic outbreaks of acute febrile illness.

244 ung children, species B rotavirus has caused sporadic outbreaks of adult diarrheal disease.

245 rus species B (RVB) has been associated with sporadic outbreaks of human adult diarrheal disease.

246 Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD)

247 litis eradication, as they are vulnerable to sporadic outbreaks through reintroduction of the disease

248 in historic pandemics and continues to cause sporadic outbreaks.

249 s and cortical inclusion cyst involvement in sporadic ovarian cancer development.

250 Furthermore, we identified three additional sporadic paediatric patients with a remarkably similar p

251 t causes yearly global epidemics, as well as sporadic pandemics due to human adaptation of pathogenic

252 IAV also causes sporadic pandemics, which can have devastating effects.

253 nimal species, causing regular epidemics and sporadic pandemics, with major public health and economi

254 public health, causing annual epidemics and sporadic pandemics.

255 a major genetic contributor to familial and sporadic Parkinson's disease (PD), a neurodegenerative m

256 saposin D domain (rs4747203 and rs885828) in sporadic Parkinson's disease had significantly higher al

257 tivation is a driver of neurodegeneration in sporadic Parkinson's disease or a mere spectator is unkn

258 t Parkinson's disease and 1934 patients with sporadic Parkinson's disease revealed another two varian

259 of the GM1 oligosaccharide for treatment of sporadic Parkinson's disease.

260 ith uveitis in the Netherlands, whereas only sporadic patients had a documented previous or active TB

261 chondrial dysfunction and their overlap with sporadic PD (sPD), opening opportunities for therapeutic

262 GCase activity is also decreased in sporadic PD brains and with normal ageing.

263 egulation of SYNJ1 transcript in a subset of sporadic PD brains, implicating a potential role of Synj

264 We conclude that in patients with sporadic PD, low levels of Abeta(1-42) are associated wi

265 gregates in Lewy bodies and Lewy neurites in sporadic PD.

266 PD), and parkin depletion may play a role in sporadic PD.

267 Approximately half of sporadic pediatric norovirus AGE cases were caused by GI

268 patterns and genotypic distribution between sporadic pediatric norovirus cases and reported noroviru

269 Sporadic pilomatricomas commonly have somatic mutations

270 Familial and sporadic porokeratosis are associated with germline hete

271 trialized region in France with a cluster of sporadic PSP cases.

272 st cells exhibited lower basal activity with sporadic pulses.

273 ether, our study uncovered an association of sporadic Q331K mutation with persistent genome damage ac

274 y one-half of the G6PD mutations are instead sporadic: rare patients with these mutations present wit

275 fects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age

276 We aimed to unravel the molecular basis of sporadic retinitis pigmentosa (sRP) in the largest cohor

277 Inherited and sporadic RP gene variants are also linked to a variety o

278 n of MITF(E318K) risk for various cancers in sporadic samples from the TCGA and several genetically-e

279 as a disease-associated gene in familial and sporadic SCAD and, together with abnormal vascular pheno

280 in the familial case and 5 individuals with sporadic SCAD from whom parental DNA was available.

281 in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N

282 es in health care coverage, she had had only sporadic screening for cervical cancer over the past 15

283 The sporadic SERS emission suggests a transient hotspot form

284 timates for risk factors were calculated for sporadic (single year of exacerbations) and recurrent (>

285 Currently, melt events are sporadic, so efficient subglacial drainage cannot be mai

286 n problems associated with bioreactor use is sporadic spikes of chemical toxins, including nanopartic

287 ne (AOM)-based setup for investigations into sporadic (Step 5A) and, when combined with dextran sodiu

288 tional changes that may underlie genetic and sporadic tau pathogenesis.

289 subjects, with a history suggesting a single sporadic trichilemmal cyst, six were likely familial due

290 e that approximately one-third of apparently sporadic trichilemmal cysts are actually familial with i

291 Of the remaining truly sporadic trichilemmal cysts that could be sequenced, onl

292 data suggests that the remaining, apparently sporadic, trichilemmal cysts are genetically distinct fr

293 In contrast, only a minority of sporadic tumors show alterations in these genes.

294 by a large number of macrophages compared to sporadic tumors.

295 ls and prevented Sca-1(+) cell expansion and sporadic tumour initiation in mutant mice, thereby demon

296 T-cell depleted immune microenvironment; 4) Sporadic UTUC is characterized by a lower total mutation

297 le for development of AD, especially for the sporadic variant, are still not clear.

298 5N6 viruses tested, from mild infection with sporadic virus dissemination beyond the respiratory trac

299 of some cancers, however, the basis of this sporadic vulnerability is unknown.

300 ting from fractionation of those revealed by sporadic weight-bearing stepping, on the other hand.