ライフサイエンスコーパス: spreading depression

1 ortex (possibly as a consequence of cortical spreading depression).

2 round 30-fold smaller than that of a wave of spreading depression).

3 ding hearing, vision, epilepsy, and cortical spreading depression.

4 thermia may be due to a reduced incidence of spreading depression.

5 e feedback in the generation of seizures and spreading depression.

6 time scale of 3 min may have been caused by spreading depression.

7 rea of the brain surface is known to trigger spreading depression.

8 l as during pathological conditions, such as spreading depression.

9 f neurons that showed activation by cortical spreading depression.

10 er loss of function, and higher incidence of spreading depression.

11 h as an increased susceptibility to cortical spreading depression.

12 op severe and prolonged motor deficits after spreading depression.

13 he trigemino-vascular system and in cortical spreading depression.

14 neuronal excitability that leads to cortical spreading depression.

15 centration of glutamine (2-5 mM) resulted in spreading-depression.

16 Minocycline had no effect on astrogliosis or spreading depression, a wave of ionic transients thought

17 rst time it has been shown that the cortical spreading depression activated the trigeminovascular sys

18 Spreading depression activates neurophysiological pathwa

19 s increased without the presence of cortical spreading depression after LEI-106 administration.

20 neurovascular dysfunction and evoke cortical spreading depression, an event that is widely thought to

21 cance to migraine of events such as cortical spreading depression and activation of the trigeminovasc

22 ical hypoperfusion responses during cortical spreading depression and alpha-chloralose anaesthesia.

23 tic glutamate receptors, which occurs during spreading depression and ischemic depolarization.

24 Daily memantine significantly reduced spreading depression and oligemia following CSD.

25 e for the occurrence of spontaneous cortical spreading depression and peri-infarct depolarizations in

26 ited increased susceptibility to subcortical spreading depression and reverberating spreading depress

27 flurane anesthesia showed that both cortical spreading depression and terminal anoxic depolarization

28 te MCA occlusion is caused by either or both spreading depression and transient ischemic depolarizati

29 We argue that the dynamics of seizures, spreading depression, and anoxic depolarization lie alon

30 le of glial K buffering against seizures and spreading depression, and provides novel insights into a

31 n other slices, APC was emulated by inducing spreading depression (as determined by a negative DC shi

32 ological ceiling that separates seizure from spreading depression, as well as predicted a second ceil

33 se gain-of-function effects lead to cortical spreading depression, aura, and potentially migraine.

34 ntral) trigeminovascular neurons by cortical spreading depression, but not their activation from the

35 s are the first to demonstrate that cortical spreading depression can be blocked in vivo using single

36 Leao's spreading depression can be observed in clinically stand

37 Cortical spreading depression caused long-lasting blood-flow enha

38 Migrainous aura is caused by cortical spreading depression (CSD) - a slowly advancing wave of

39 However, the relationship between cortical spreading depression (CSD) and headache has not been ful

40 ow (rCBF) changes that occur during cortical spreading depression (CSD) are considered to be an exper

41 , although, animal models highlight cortical spreading depression (CSD) as a potential candidate.

42 ing has confirmed the importance of cortical spreading depression (CSD) as the pathophysiological mec

43 A key finding was that cortical spreading depression (CSD) due to electrode insertion in

44 t and characterize complex waves of cortical spreading depression (CSD) evoked with KCL placed upon t

45 Cortical spreading depression (CSD) has been documented to confer

46 Cortical spreading depression (CSD) has been implicated in migrai

47 Cortical spreading depression (CSD) has been suggested to underli

48 Cortical spreading depression (CSD) has long been implicated in m

49 Animal studies of cortical spreading depression (CSD) have benefited greatly from t

50 tensive care and were classified as cortical spreading depression (CSD) if they took place in spontan

51 nnelrhodopsin to trigger and record cortical spreading depression (CSD) in freely behaving subjects.

52 Cortical spreading depression (CSD) is a key pathogenetic step in

53 Cortical spreading depression (CSD) is a propagating event of neu

54 Cortical spreading depression (CSD) is a propagating wave of neur

55 Cortical spreading depression (CSD) is a self-propagating wave of

56 Cortical spreading depression (CSD) is a transient propagating ex

57 Cortical spreading depression (CSD) is a wave of neuronal depolar

58 Cortical spreading depression (CSD) is a wave of neuronal depolar

59 Cortical spreading depression (CSD) is associated with release of

60 Cortical spreading depression (CSD) is characterized by slowly pr

61 Cortical spreading depression (CSD) is likely the underlying phen

62 Cortical spreading depression (CSD) is the propagation of a relat

63 Cortical spreading depression (CSD) is thought to be a fundamenta

64 Cortical spreading depression (CSD) may be the underlying mechani

65 Cortical spreading depression (CSD) underlies the neurobiology of

66 Cortical spreading depression (CSD) was induced by transient (10

67 to be the key factor for generating cortical spreading depression (CSD), a pathological mechanism of

68 Cortical spreading depression (CSD), a physiological correlate of

69 d, if so, the threshold for evoking cortical spreading depression (CSD), a process sharing characteri

70 icient to cause infarcts, triggered cortical spreading depression (CSD), a propagating slow depolariz

71 on exhibit increased propensity for cortical spreading depression (CSD), a propagating wave of neurog

72 Cortical spreading depression (CSD), a wave of depolarization fol

73 Cortical spreading depression (CSD), a wave of neuronal depolariz

74 mice, we show that a single wave of cortical spreading depression (CSD), an animal model of migraine

75 urological deficits associated with cortical spreading depression (CSD), preceding headache attacks.

76 nnels and are highly susceptible to cortical spreading depression (CSD), the electrophysiologic event

77 Here, we report that cortical spreading depression (CSD), the electrophysiological sub

78 We evaluated the ability of cortical spreading depression (CSD), the proposed mechanism of th

79 ring somatosensory stimulations and cortical spreading depression (CSD), the putative mechanism of th

80 optical triggering and recording of cortical spreading depression (CSD), the slowly propagated wave o

81 n damage and ischemia often trigger cortical spreading depression (CSD), which aggravates brain damag

82 this study was to determine whether cortical spreading depression (CSD)--an event believed to underli

83 ceptors, it significantly reduces a cortical spreading depression (CSD)-induced early response probab

84 us and evoked activity in naive and cortical spreading depression (CSD)-sensitized trigeminovascular

85 range trigeminovascular neurons by cortical spreading depression (CSD).

86 s (with [n=7] or without [n=7] HH), cortical spreading depressions (CSD) were elicited to ascertain t

87 Recurrent spreading depression episodes were induced by applicatio

88 ecovery rate for [K+]o, and interval between spreading depression episodes were measured before and a

89 ection analysis) and in vivo (i.e., during a spreading depression event in an anesthetized rat).

90 TPase knockout triggers spontaneous cortical spreading depression events that are associated with EEG

91 factor in the clinical response to cortical spreading depression events.

92 d the effect of fremanezumab on the cortical spreading depression-evoked activation of mechanosensiti

93 s predicted a second ceiling that demarcates spreading depression from anoxic depolarization.

94 e) that is evident in human (unlike cortical spreading depression) gives rise to specific and selecti

95 Although spreading depression has been known for over 50 years, r

96 ding depolarization, usually termed cortical spreading depression has been proposed as the pathophysi

97 velength optical intrinsic imaging, cortical spreading depression has been shown to have a triphasic

98 Upstream events such as cortical spreading depression have also been modeled recently and

99 The pathological phenomena of seizures and spreading depression have long been considered separate

100 Pathological conditions, such as spreading depression, have been linked to abnormal range

101 Hyperthermic spreading depression (HSD) in immature rat hippocampal s

102 and headache by demonstrating that cortical spreading depression, implicated in migraine visual aura

103 cerebral ischaemia, and blocking of cortical spreading depression improved stroke outcome in these mi

104 provides evidence for an integrative role of spreading depression in brain pathophysiology.

105 ound, global cerebral ischemia, and cortical spreading depression in C57BL6 mice; 1 day after probe d

106 ge, but it is unknown whether TNF influences spreading depression in cerebral cortex in vivo.

107 signals evoked by stimulation, seizures and spreading depression in intact brain differ from those o

108 o each headache disorder, including cortical spreading depression in migraine, rhythmicity of attacks

109 viously implicated in mechanisms of cortical spreading depression in migraine.

110 in extracellular diffusion that occur during spreading depression in rat hippocampal slices.

111 ole in the return of [K+]o to baseline after spreading depression in the cortex in vivo.

112 urovascular changes associated with cortical spreading depression in the mouse.

113 mulation blocked the propagation of cortical spreading depression in two of eight animals.

114 Enhanced susceptibility to cortical spreading depression increased sensitivity to focal cere

115 ity in reducing the total number of cortical spreading depressions induced by potassium chloride.

116 mechanism for the susceptibility of cortical spreading depression initiation in migraine disorders.

117 Cortical spreading depression is a propagating wave of depolariza

118 The findings indicate that cortical spreading depression is accompanied by transient neurobe

119 Our understanding of cortical spreading depression is also advancing.

120 These findings indicate that cortical spreading depression is associated with a multiphasic al

121 Cortical spreading depression is associated with profound vascula

122 ed significantly reduced NVC efficiency upon spreading depression-like (SDL) events, providing a dire

123 ere correlated to optogenetically evoked and spreading depression-like calcium events.

124 Hypoxia-induced spreading depression-like depolarization (hypoxic SD, or

125 larizations (PIDs) are seemingly spontaneous spreading depression-like waves that negatively impact t

126 Results support a spreading, depression-like neuroelectric event occurring

127 Vascular/metabolic uncoupling with cortical spreading depression may have important clinical consequ

128 the central autonomic response and cortical spreading depression might drive cerebrovascular reactiv

129 strated significant activity in the cortical spreading depression model of migraine as we reported pr

130 larly, SNC80 was ineffective in the cortical spreading depression model of migraine aura in condition

131 atine for 3 h failed to prevent hyperthermic spreading depression occurrence; and (2) intracellular A

132 utic targets in the disorders where cortical spreading depression occurs.

133 oelectric and metabolic event likened to the spreading depression of Leao.

134 The effect of spreading depression on extracellular space is much larg

135 tibility to ischemic depolarizations akin to spreading depression predisposes migraineurs to infarcti

136 Altogether, these data show that spreading depression propagates between cortex, basal ga

137 ing, and c-fos immunohistochemistry to trace spreading depression propagation into subcortical struct

138 e showed that unlike the wild type, cortical spreading depression readily propagated into subcortical

139 t astrocytes normally extrude calcium during spreading depression, resulting in rapid recovery of the

140 Although intercellular Ca2+ waves resemble spreading depression (SD) and occur in hippocampal organ

141 spontaneous, recurring episodes of cortical spreading depression (SD) as early as 20 min post-inject

142 Spreading depression (SD) has been demonstrated followin

143 occlusion, as well as the effects of induced spreading depression (SD) in intact animals.

144 We have developed an in vitro model of spreading depression (SD) in rat neocortex.

145 We examined characteristics of spreading depression (SD) induced on the rat cortex 1 da

146 Spreading depression (SD) involves current flow through

147 Spreading depression (SD) is a propagating wave of neuro

148 Cortical spreading depression (SD) is a spreading disruption of i

149 Spreading depression (SD) is a wave of cellular depolari

150 Spreading depression (SD) is an intense and prolonged de

151 Cortical spreading depression (SD) is an intense depolarization u

152 Spreading depression (SD) is wave of profound depolariza

153 The possibility that spreading depression (SD) of cortical activity, a phenom

154 stigated the role of spontaneous and induced spreading depression (SD) on the evolution of focal isch

155 Spontaneous episodes of spreading depression (SD) originating in multiple source

156 Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanis

157 ant, on fluid shifts, cerebral perfusion and spreading depression (SD) using diffusion- (DWI) and per

158 Spreading depression (SD), a slow diffusion-mediated sel

159 Spreading depression (SD), a slowly propagating neuronal

160 This study used spreading depression (SD), which is characterized by red

161 In the ischemic periphery, spreading depression (SD)-like waves of depolarization w

162 , I(Na,P), in the generation of seizures and spreading depression (SD).

163 expression following unilateral neocortical spreading depression (SD).

164 receded by an aura likely caused by cortical spreading depression (SD).

165 ous transition between epileptic seizure and spreading depression states as the cell swells and contr

166 ssium or hypoxia induced), mixed seizure and spreading depression states, and the terminal anoxic "wa

167 mone levels in these mice modulated cortical spreading depression susceptibility in much the same way

168 smooth muscle Notch 3 mutations to enhanced spreading depression susceptibility, implicating the neu

169 mutation are highly susceptible to cortical spreading depression, the electrophysiological surrogate

170 During spreading depression, the evoked increase in cytosolic C

171 Amiloride was shown to block cortical spreading depression, the experimental correlate of aura

172 We tested the susceptibility of cortical spreading depression, the experimental correlate of migr

173 This paper shows that cortical spreading depression, the neural correlate of migraine a

174 at cortices, when administered post-cortical spreading depression, transcranial magnetic stimulation

175 unction, one during the propagating cortical spreading depression wave and a second much longer phase

176 t current shift associated with the cortical spreading depression wave was accompanied by marked arte

177 concentration increased during the cortical spreading depression wave, but recovered and remained at

178 mum direct current shift associated with the spreading depression wave, then gradually resumed over s

179 After recovery from the initial cortical spreading depression wave, we observed a second phase of

180 istinct from the initial propagated cortical spreading depression wave.

181 tical spreading depression and reverberating spreading depression waves.

182 h mechanical and chemically-induced cortical spreading depression when administered immediately post-

183 euronal activities, from spikes to seizures, spreading depression (whether high potassium or hypoxia

184 ion and c-fos expression are associated with spreading depression, which is believed to contribute to

185 asses controversies associated with cortical spreading depression, which is less readily observed in

186 ity, and enhanced susceptibility to cortical spreading depression, which is the electrophysiological

187 TAC-Red-stained brain cortex in mice during spreading depression, with velocity 4.4 +/- 0.5 mm/min,

188 and transient ischaemia can trigger cortical spreading depression without an enduring tissue signatur