ライフサイエンスコーパス: sputum culture

1 plex isolates recovered from cystic fibrosis sputum culture.

2 utum smear and the clearance of organisms in sputum culture.

3 rial load (>=10(7) cfu/g) using quantitative sputum culture.

4 ared for patients with positive and negative sputum culture.

5 months 12 and 24 using chest radiography and sputum culture.

6 ite were also more likely to have a positive sputum culture.

7 abinomannan assay (LF-LAM), chest x-ray, and sputum culture.

8 osis cases compared to sputum Xpert Ultra or sputum culture.

9 % CI, 99.2%-99.5%) relative to a single spot sputum culture.

10 e prevalence ratios associated with positive sputum culture.

11 PTB), normal chest radiographs, and positive sputum culture.

12 ximately 20% reduction in yield from induced sputum culture.

13 microbiologically confirmed with a positive sputum culture.

14 h the presence of filamentous fungi positive sputum culture.

15 We excluded tuberculosis at screening by sputum culture.

16 nging drug-susceptibility patterns in serial sputum cultures.

17 etween those with and those without positive sputum cultures.

18 dren and adults with CF who had quantitative sputum cultures.

19 aureus and P. aeruginosa are abundant in CF sputum cultures.

20 LAI group demonstrated at least one negative sputum culture (14 [32%] of 44 vs. 4 [9%] of 45; P = 0.0

21 in-house PCR (2.6 vs 24.1 h, p < 0.001) and sputum cultures (2.6 vs 57.5 h, p < 0.001).

22 s aeruginosa was the most common organism in sputum culture (301 [13.7%]) in India.

23 ive than culture in detecting Aspergillus in sputum (culture 37%, RT-PCR 74%, and GM 46%).

24 13 specimens from TB suspects with negative sputum cultures, 7 had a positive MTBDRplus assay (3 wit

25 rculosis negative (by 2 GeneXpert tests or 2 sputum cultures) after 4-5 months of TB treatment, and n

26 00 cells/mul), sputum Xpert, and/or a single sputum culture among consecutive people living with HIV

27 illance for drug-resistant tuberculosis with sputum culture and drug susceptibility testing in patien

28 fungal sensitization and/or positive fungal sputum culture and markers of asthma severity in childre

29 m smear microscopy was compared with that of sputum culture and the Xpert MTB/RIF assay for all patie

30 tum microbiological reference standard (MRS; sputum culture and/or Xpert Ultra).

31 Sputum cultures and antibiotic sensitivities were follow

32 eled bacillary elimination rates (BERs) from sputum cultures and calculated the percentage of lipid b

33 patients, each of whom had multiple positive sputum cultures and clinical evidence of infection.

34 ipoarabinomannan [TB-LAM], sputum Ultra, and sputum culture), and stratified by CD4 cell count.

35 ith sputum Ultra, 29% (38/133) compared with sputum culture, and 33% (44/133) compared with TB-LAM.

36 neumonia in Kenyan adults to justify routine sputum culture, and that treatment with benzylpenicillin

37 es, a quarter of nonsevere patients received sputum cultures, and treatment with broad-spectrum agent

38 who have failed treatment and have positive sputum cultures are being discharged from hospital and a

39 ated 5 different diagnostic strategies using sputum culture as a reference standard (Xpert alone, LAM

40 eference to three Mycobacterium tuberculosis sputum cultures, as compared with that of a single sputu

41 Q total score, and Pseudomonas aeruginosa in sputum culture at baseline.

42 ntly associated with higher odds of positive sputum cultures at 2 months.

43 ble Haemophilus influenzae was isolated from sputum cultures at 22 of 23 monthly clinic visits.

44 The primary efficacy end point was negative sputum cultures at completion of intensive phase.

45 1 patients in the control group had negative sputum cultures at month 2 (P < .001).

46 ed pneumococcal if either sputum Gram stain, sputum culture, blood culture, or the immunochromatograp

47 oduct of PZA, directly in the supernatant of sputum cultures by detecting a color change following th

48 ion up to only 56 days, lack of quantitative sputum culture CFU count data, and no examination of the

49 a composite reference standard of TB-LAM and sputum culture (CMRS2).

50 quantify POA directly in the supernatant of sputum cultures collected from TB patients.

51 ent for multidrug-resistant TB, high initial sputum culture colony count, bilateral cavitations on ch

52 fect of vitamin D supplementation on time to sputum culture conversion (p(interaction)=0.03), with en

53 ss the impact of PZA gDST and MIC on time to sputum culture conversion (SCC) and treatment outcome in

54 on overall adverse events (AE), hepatic AE, sputum culture conversion (SCC) at week 8, recurrence, m

55 terium abscessus (Mab) lung disease achieves sputum culture conversion (SCC) rates of 35%.

56 mpleted or in care) at 18 months and time to sputum culture conversion (SCC).

57 ex (MAC) pulmonary disease achieve sustained sputum culture conversion (SSCC) on treatment with the a

58 second-line tuberculosis drugs with time to sputum culture conversion (tSCC) and treatment outcome i

59 We compared time to sputum culture conversion (TSCC) using Kaplan-Meier curv

60 The primary outcome was time to sputum culture conversion (tSCC).

61 endpoint was the proportion of patients with sputum culture conversion after 1 and 2 months of treatm

62 The rate of sputum culture conversion after 1 month of tuberculosis

63 from hospital, of whom 26 (58%) had achieved sputum culture conversion and 19 (42%) had failed treatm

64 by analyzing the association between time to sputum culture conversion and both the number of potenti

65 lidate our results by estimating the time to sputum culture conversion and compare the results to a d

66 of special interest in all participants and sputum culture conversion and end-of-treatment outcomes

67 egimens were associated with higher rates of sputum culture conversion and favorable outcomes and a l

68 Rates of sputum culture conversion and favorable treatment outcom

69 ata provide evidence of an early increase in sputum culture conversion and greater radiographic impro

70 metformin with standard ATT reduces time to sputum culture conversion and tissue inflammation in adu

71 Time to initial sputum culture conversion and treatment outcome.

72 gating the effect of adjunctive vitamin D on sputum culture conversion are absent.

73 We defined sputum culture conversion as two or more consecutive neg

74 Adjusted rates of sputum culture conversion at 2 months (67% vs 47%, respe

75 Rapid sputum culture conversion at 2 months indicates the ster

76 Sputum culture conversion at 6 months ranged from 61% to

77 Adjusted rates of sputum culture conversion at two months (67 vs. 47%, p=0

78 ider these results regarding the validity of sputum culture conversion at various timepoints as an ea

79 Increasing doses improved sputum culture conversion at week 8 (RR 1.3, 95% CrI: 1.

80 of metformin to standard ATT did not hasten sputum culture conversion but diminished excess inflamma

81 The primary end point was time to sputum culture conversion by liquid culture during 8 wee

82 The median time to sputum culture conversion by liquid culture was 42 days

83 We compared results of sputum culture conversion by moxifloxacin and control re

84 Median time to sputum culture conversion did not differ between the two

85 population, but it did significantly hasten sputum culture conversion in participants with the tt ge

86 Adjunctive vitamin D3 accelerated sputum culture conversion in patients with one or more m

87 verity, higher bacterial burden, and delayed sputum culture conversion in pulmonary tuberculosis (PTB

88 everity, higher bacterial burden and delayed sputum culture conversion in pulmonary tuberculosis (PTB

89 moxifloxacin results in significantly higher sputum culture conversion in the first 2 months compared

90 Vitamin D3 did not influence time to sputum culture conversion in the study population overal

91 tamin D did not significantly affect time to sputum culture conversion in the whole study population,

92 Sputum culture conversion is a useful and appropriate in

93 Sputum culture conversion is often used as an early micr

94 Net sputum culture conversion occurred in 22 patients (21%)

95 We aimed to assess the validity of sputum culture conversion on solid media at varying time

96 garding whether nontuberculous mycobacterial sputum culture conversion or semiquantitative culture an

97 CAD (AMI(-) or AMI(+)) or ATS did not change sputum culture conversion or sputum smear AFB positivity

98 Primary outcomes were the time to sputum culture conversion over 6 months and the differen

99 he difference in the distribution of time to sputum culture conversion over 6 months between the two

100 The reduction in median time to sputum culture conversion over 6 months was not signific

101 /L; P < 0.001) but did not influence time to sputum culture conversion overall (adjusted hazard ratio

102 The primary and secondary outcomes were the sputum culture conversion rate at the end of 8 weeks and

103 Sputum culture conversion rates among patients exposed a

104 Sputum culture conversion status at 2 months was signifi

105 Conversely, 6 month sputum culture conversion status had high sensitivity (9

106 with greater increases in the likelihood of sputum culture conversion than including more drugs to w

107 associated with a 36% greater likelihood of sputum culture conversion than receiving an average of a

108 Independent predictors of a longer sputum culture conversion time, using an accelerated fai

109 adiographic improvement as well as long-term sputum culture conversion to negative in this population

110 butol that is continued for 12 months beyond sputum culture conversion to negative.

111 Sputum culture conversion using solid medium is the best

112 Median time to sputum culture conversion was 36.0 days in the intervent

113 Sputum culture conversion was analyzed in 780 (616 in th

114 mum combined sensitivity and specificity for sputum culture conversion was reached between month 6 an

115 ients with treatment success, median time to sputum culture conversion was significantly shorter than

116 In addition, the adjusted proportion of sputum culture conversion was similar between the daily

117 c improvement, radiographic improvement, and sputum culture conversion were not different between the

118 Thus, the overall association of sputum culture conversion with a successful outcome was

119 atients with multidrug-resistant TB achieved sputum culture conversion within 12 weeks of starting tr

120 dance.Objectives: We report the frequency of sputum culture conversion within 6 months of treatment i

121 rug regimen, 80% of participants experienced sputum culture conversion within 6 months.

122 All patients achieved sputum culture conversion within a mean of 71 days (26-1

123 All patients achieved sputum culture conversion within a mean of 71 days (26-1

124 part of a multidrug regimen, 80% experienced sputum culture conversion within six months.

125 hic severity of disease, the longest time to sputum culture conversion, and the highest rates of trea

126 The primary efficacy outcome was time to sputum culture conversion, and the primary safety outcom

127 Time to sputum culture conversion, conversion status at 6 months

128 Cavitation may lead to delayed sputum culture conversion, emergence of drug resistance,

129 egimens were associated with higher rates of sputum culture conversion, more favorable outcomes, and

130 act that the analysis considers only initial sputum culture conversion, not reversion or long-term re

131 r, the response to treatment is monitored by sputum culture conversion, which takes several weeks for

132 rom initiation of antimicrobial treatment to sputum culture conversion.

133 of AEs but did not result in faster time to sputum culture conversion.

134 um smear grading were associated with faster sputum culture conversion.

135 IV and associated with a trend toward faster sputum culture conversion.

136 outcome, and hazard ratios (HRs) for time to sputum culture conversion.

137 and stratified by risk category for delayed sputum culture conversion.

138 on-dependent antagonism that reduces 2-month sputum culture conversion.

139 The primary outcome of interest was initial sputum culture conversion.

140 ily had a higher proportion of patients with sputum-culture conversion (41.9%, P=0.04).

141 Delamanid was associated with an increase in sputum-culture conversion at 2 months among patients wit

142 s 100 mg of delamanid twice daily, 45.4% had sputum-culture conversion in liquid broth at 2 months, a

143 nd point was the proportion of patients with sputum-culture conversion in liquid broth medium at 2 mo

144 e primary efficacy end point was the time to sputum-culture conversion in liquid broth.

145 nthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-res

146 The findings were similar with assessment of sputum-culture conversion in solid medium.

147 e use of both liquid broth and solid medium; sputum-culture conversion was defined as a series of fiv

148 Treatment outcomes were defined as 2-month sputum-culture conversion, treatment episode outcome, an

149 1 month, the proportion of patients for whom sputum culture converted to negative was 17% for the IL-

150 hout treatment was greater in subjects whose sputum cultures converted to negative by the eighth week

151 significant difference between fast and slow sputum culture converters after 2 months following treat

152 antly different between the slow vs the fast sputum culture converters after 2 months of treatment (p

153 Chest radiography and sputum culture drug susceptibility testing can assist ph

154 n of patients with tuberculosis diagnosed by sputum culture during screening before antiretroviral th

155 m specimens, 458 (91.6%) had both a positive sputum culture for Mycobacterium tuberculosis and a vali

156 pert MTB/RIF Ultra assay on sputum or urine, sputum culture for Mycobacterium tuberculosis, and CD4 c

157 osis based on both WHO criteria and positive sputum culture for mycobacterium Tuberculosis.

158 Sputum culture for pre-migration screening and active re

159 tification testing (IgG, IgA, IgE, and IgM); sputum cultures for bacteria, mycobacteria, and fungi; a

160 Sputum cultures for two patients whose nebulizers were c

161 DNA fingerprinting analysis of serial sputum cultures from 48 patients with MDR tuberculosis a

162 Serial M. tuberculosis sputum cultures from patients diagnosed with multi-drug-

163 control regimen, age (>/=35 years), initial sputum culture grade (2+ or 3+), and male sex were signi

164 ade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis.

165 CAP, if blood culture, induced good-quality sputum culture, Gram stain, or urinary Binax demonstrate

166 Pretransplantation sputum cultures grew Aspergillus fumigatus in seven pati

167 Improvement in sputum culture, high-resolution computed tomography (HRC

168 ominant potential pathogen was identified in sputum culture in 70 of 417 case patients (17%).

169 quencies of positive, potentially pathogenic sputum cultures in chronic obstructive pulmonary disease

170 d after >or=4 consecutive months of negative sputum cultures, in prospective macrolide treatment tria

171 ful downstream comparisons reveal sources of sputum-culture incongruences due to false positive/negat

172 including the use of DNA-based methods, for sputum culture isolates presumptively identified as B. c

173 isolation of Pseudomonas aeruginosa (PA) in sputum cultures, it remains unknown whether the empirica

174 ing MacConkey plate to the routine media for sputum culture may provide additional, clinically releva

175 Typical sputum culture methods quantitate the relative amounts o

176 Monthly sputum cultures, minimal inhibitory concentration testin

177 Clinical information, sputum cultures, molecular typing of isolates, and immun

178 cans from participants successfully treated (sputum culture negative 18 months after enrolment) for d

179 Coprimary outcomes were negative sputum culture on liquid and on solid media at completio

180 uth African adults if blood culture, induced-sputum culture or Gram stain, urine antigen test, or who

181 Patients with positive Aspergillus sputum culture or positive bronchoalvelolar lavage (BAL)

182 Diagnosis requires 2 or more positive sputum cultures or 1 bronchoscopic specimen culture.

183 fined as at least three consecutive negative sputum cultures over a period of at least 3 months, was

184 ron mycotoxinivorans recovered from multiple sputum cultures over time with various clinical conseque

185 paradox we generate high-quality genomes of sputum-culture pairs from two different settings after d

186 , we identify a 97% variant agreement within sputum-culture pairs, with a high correlation also in th

187 and normal chest radiographs, 937 (57%) had sputum culture performed, and 127 (13%) patients had pos

188 acteria, 16 atypicals, and 164 viruses) than sputum culture plus any standard-of-care testing (91% vs

189 r patients were recruited, and 44 (43%) were sputum culture positive for M. tuberculosis.

190 At week 8, fewer patients remained sputum culture positive on higher-dose rifampicin (18.6%

191 with cystic fibrosis (CF) who had antemortem sputum cultures positive for nontuberculous mycobacteria

192 Although people with HIV frequently have sputum cultures positive for NTM, few meet a strict case

193 und in patients who had only one of multiple sputum cultures positive for NTM.

194 Additional longitudinal studies with sputum culture-positive and -negative control participan

195 Among 167 patients who were sputum culture-positive at initiation of second-line the

196 rom May 2009 to January 2011, we enrolled 96 sputum culture-positive index TB cases and their 442 con

197 rformed whole-genome sequencing (WGS) of Mtb sputum culture-positive isolates from participants in tw

198 Individualized treatment for confirmed sputum culture-positive pulmonary multidrug-resistant TB

199 trospective cohort study among patients with sputum culture-positive tuberculosis was performed.

200 tcome was daily percentage change in time to sputum culture positivity (TTP) in liquid medium over da

201 ol regimens and identified factors affecting sputum culture positivity after 2 months of treatment.

202 ment, as well as sputum smear microscopy and sputum culture positivity at 2 and 6 months.

203 In both surveys, sputum culture positivity was associated with male sex a

204 ment, as well as sputum-smear microscopy and sputum-culture positivity at 2 and 6 months.

205 evalence of Mycobacterium tuberculosis (Mtb) sputum culture-positivity among adult clinic attendees i

206 -3.58), less likely to convert to a negative sputum culture (PR, 0.55; 95% CI, 0.33-0.94), and had a

207 are established, it would be prudent to do a sputum culture prior to IPT where this is feasible.

208 We used a sputum culture reference standard.

209 diographic, and microbiological (including 2 sputum cultures, repeat Ultra, and for people with HIV,

210 nts, 54% on ART, had symptom screening and a sputum culture result available.

211 Treatment outcomes were conversion of sputum culture results at 2 months and time to conversio

212 The objective of this study was to evaluate sputum culture results on solid media during treatment a

213 outcome at week 73, defined by two negative sputum culture results or favorable bacteriologic, clini

214 efore receiving study drug or whose baseline sputum culture results suggested prevalent tuberculosis.

215 Of 676 participants with available sputum culture results, 89 (13%) had culture-confirmed t

216 relation between their CT features and their sputum culture results.

217 Sputum culture reversion after conversion is an indicato

218 We suggest that semiquantitative sputum culture scores can be a useful tool for evaluatin

219 Baseline semiquantitative sputum culture scores did not differ between patients wi

220 The change in sputum culture semiquantitative score from baseline to M

221 sequential isolates from 49 patients who had sputum cultures separated by at least 90 days that grew

222 UAVs on microbiological specimens, blood and sputum culture specimens were seeded with usual pathogen

223 Sputum cultures, sputum interleukin 8 and neutrophil ela

224 The primary endpoint was sputum culture status at 2 mo of treatment.

225 fampin, and pyrazinamide did not affect 2-mo sputum culture status but did show increased activity at

226 .7-fold more likely to achieve conversion of sputum culture than those whose FENO decreased (odds rat

227 Coprimary efficacy outcome was week 8 sputum culture time-to-positivity (TTP) in randomized co

228 The ability of the clinical sputum culture to hydrolyze PZA was determined, and the

229 eatment, and relationship with conversion of sputum culture to negative at 2 months.

230 ersion of a Mycobacterium tuberculosis (Mtb) sputum culture to negative.

231 (95%CI:10-44) in the before period converted sputum cultures to negative by 8 months following treatm

232 tently colonized with H. influenzae and that sputum cultures underestimate the frequency of colonizat

233 ), for sputum Ultra was 6% (39/677), and for sputum culture was 4% (30/677).

234 Sputum cultures were assessed weekly with the use of bot

235 Laboratory values of safety and sputum cultures were collected at Weeks 1, 2, 3, 4, 6, 8

236 Overnight sputum cultures were collected daily.

237 sputum cultures were positive than when the sputum cultures were negative (7.9 versus 5.6 log10 copi

238 Gastric and sputum cultures were obtained from fifteen CF patients r

239 Sputum cultures were obtained, and individual colonies w

240 opy numbers from sputum were higher when the sputum cultures were positive than when the sputum cultu

241 MODS detected 94.0% of 1,908 positive sputum cultures, whereas Lowenstein-Jensen (LJ) culture

242 Sputum cultures, which are likely to have the highest di

243 berculin skin test and negative results of a sputum culture who were cleared of TB disease based on a

244 blood, tissues, or respiratory samples (>=2 sputum cultures with the same species or 1 bronchoscopic

245 worse for patients who did not convert their sputum culture within 2 months.

246 censing for DR tuberculosis based on 2-month sputum culture would shorten time to initial approval by

247 Four of the patients' sputum cultures yielded growth of M. kansasii within 6 t