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1 , exhibited lower affinities for recombinant squalene synthase.
2 potencies as inhibitors of recombinant yeast squalene synthase.
3 ctivity against Ras farnesyl transferase and squalene synthase.
4 in isoprenylation that are not inhibitors of squalene synthase.
5  not nSREBP-1a, to activate the promoter for squalene synthase.
6 eductase, farnesyl diphosphate synthase, and squalene synthase.
7 eling of bisphosphonate molecules binding to squalene synthase.
8 nate molecules that were designed to inhibit squalene synthase.
9                We pharmacologically validate squalene synthase, a cholesterol biosynthetic enzyme enc
10                  Silencing of N. benthamiana SQUALENE SYNTHASE, a key gene in phytosterol biosynthesi
11      Farnesyl diphosphate, the substrate for squalene synthase, accumulates in the presence of zarago
12 l CoA (HMG CoA) synthase, HMG CoA reductase, squalene synthase, acetyl-CoA carboxylase, fatty acid sy
13  biosynthesis inhibitors with essentially no squalene synthase activity.
14 geranyl-protein transferase-I (GGPTase-I) or squalene synthase activity.
15                         Inhibition of FPP or squalene synthase allowed for the further identification
16       These findings were unexpected because squalene synthase, an ancient and likely progenitor to t
17 nes, less robust associations were found for squalene synthase and change in total cholesterol, apoli
18 that a botryococcene synthase would resemble squalene synthase and hence isolated squalene synthase-l
19 olesterol synthesis genes HMG CoA reductase, squalene synthase, and FPP synthase but did not alter le
20 f farnesyl-diphosphate farnesyl transferase (squalene synthase), but not 3-hydroxy-3-methylglutaryl-C
21                                              Squalene synthase catalyzes the biosynthesis of squalene
22                                              Squalene synthase catalyzes the conversion of two molecu
23                                              Squalene synthase catalyzes two consecutive reactions in
24  the crystal structures of recombinant human squalene synthase complexed with several different inhib
25 key amino acid residues that can convert the squalene synthase enzyme into peplusol synthase and vice
26                    The strain was blocked at squalene synthase (ERG9 gene) in the isoprenoid pathway
27 anosterol 14alpha-demethylase (CYP51A1), and squalene synthase (farnesyl diphosphate farnesyl transfe
28 yl-CoA carboxylase, stearoyl-CoA desaturase, squalene synthase, farnesyl-pyrophosphate synthase, 3-hy
29                                Deletion of a squalene synthase gene in the FAC restored wild-type che
30  another tightly regulated sterol-responsive squalene synthase gene was unaffected.
31                   Transcription of the human squalene synthase (HSS) gene is regulated by variations
32                      The expression of human squalene synthase (HSS) gene is transcriptionally regula
33  (K(i) = 0.06 microM, IC(50) = 20 microM) or squalene synthase (IC(50) = 1000 microM).
34 tion of zaragozic acid--a known inhibitor of squalene synthases--impaired biofilm formation and prote
35 aryl-CoA reductase, fatty-acid synthase, and squalene synthase in livers of Zetia/lovastatin-treated
36  farnesyl diphosphate with recombinant yeast squalene synthase in the absence of NADPH gives a mixtur
37                                              Squalene synthase inhibition was quantified using a cell
38                                              Squalene synthase inhibition with lapaquistat acetate, a
39 f rat hepatocytes as a direct consequence of squalene synthase inhibition, we investigated possible u
40                     Lapaquistat acetate is a squalene synthase inhibitor investigated for the treatme
41                    In the present study, the squalene synthase inhibitor squalestatin reduced the cho
42  A reductase inhibitor lovastatin and by the squalene synthase inhibitor zaragozic acid A and was pre
43 action for the efficient construction of the squalene synthase inhibitor zaragozic acid C.
44 sterol biosynthetic pathway: squalestatin 1 (squalene synthase inhibitor), (E)N-ethyl-N-(6,6-dimethyl
45                   The synthesis of the novel squalene synthase inhibitor, bisabosqual A, was complete
46 tures with SQ-34919, a structurally distinct squalene synthase inhibitor, produced the same selective
47 lates in the presence of zaragozic acid A, a squalene synthase inhibitor.
48 bon diverted from cholesterol synthesis by a squalene synthase inhibitor.
49 ment with multiple statins, bisphosphonates, squalene synthase inhibitors, and small interfering RNA
50 ted a much improved in vitro antioxidant and squalene synthase inhibitory activity (at lower micromol
51                                              Squalene synthase is inhibited at high concentrations of
52  of PSPP or a prior conformational change in squalene synthase is the rate-limiting step for synthesi
53 nthase, farnesyl pyrophosphate synthase, and squalene synthase, key enzymes for cholesterol synthesis
54 ubation of [(14)C]FDP with recombinant human squalene synthase led to [(14)C]PSDP and [(14)C]squalene
55 l squalene synthase, none of the other three squalene synthase-like (SSL) genes encodes for botryococ
56 esemble squalene synthase and hence isolated squalene synthase-like genes from Botryococcus braunii r
57  treatment with bisphosphonates that inhibit squalene synthase might help protect tissues against pat
58 4S-hydroxycholesterol, HMG CoA reductase and squalene synthase mRNA levels were significantly decreas
59  B. braunii does harbor at least one typical squalene synthase, none of the other three squalene synt
60 hen co-expressed in yeast with complementary squalene synthase or botryococcene synthase expression c
61 tores are reduced secondary to inhibition of squalene synthase or LDL receptor degradation is disrupt
62 se farnesyl diphosphate synthase rather than squalene synthase or phytoene synthase, which catalyze c
63 conversion to squalene through the action of squalene synthase represents the first committed step in
64                                  Rat hepatic squalene synthase (RSS, EC 2.5.1.21) contains three cons
65                                              Squalene synthase (SQase) catalyzes the condensation of
66                                              Squalene synthase (SQase) catalyzes two consecutive reac
67 heir ability to inhibit rat liver microsomal squalene synthase (SQS) in vitro.
68 ent are a new class of potent, orally active squalene synthase (SQS) inhibitors.
69 in which antioxidant, anti-inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activit
70                                              Squalene synthase (SQS) is a bifunctional enzyme that ca
71                                              Squalene synthase (SQS) was up-regulated in CL1-5 cells
72 vels, signal peptide peptidase (SPP) cleaves squalene synthase (SQS), an enzyme that defines the bran
73 he activity of these compounds against human squalene synthase (SQS), as a counterscreen, finding sev
74 uctase (Red), fatty acid synthase (FAS), and squalene synthase (SQS).
75 es with nanomolar inhibitory activity toward squalene synthase (SQS).
76             One TBF-resistant cosmid encoded squalene synthase (SQS1), which is located upstream of t
77                                              Squalene synthase (SS) represents a putative branch poin
78 ly enzymes of triterpene aglycone formation: squalene synthase (SS), squalene epoxidase (SE), and bet
79                                          Two squalene synthase (SS)-like complementary DNAs are ident
80 n to inhibit cholesterol biosynthesis at the squalene synthase step, may afford a novel series of hyp
81 e-specific manner, whereas the expression of squalene synthase, sterol response element-binding prote
82                                  Conversely, squalene synthase (terminal cholesterol synthesis) block
83 doned drug lapaquistat, an inhibitor of host squalene synthase that shifts the redox environment, blo
84 t with squalestatin 1, a potent inhibitor of squalene synthase, the first committed enzyme of sterol
85  of cholesterol biosynthesis is catalyzed by squalene synthase, we explored whether inhibiting this e