ライフサイエンスコーパス: squamous carcinoma

1 cancers (NSCLCs) (19 adenocarcinomas and 19 squamous carcinoma).

2 group (n=1 septic shock, n=1 metastatic skin squamous carcinoma).

3 nsgenic mice elicits a multistage pathway to squamous carcinoma.

4 omplete response rate noted in patients with squamous carcinoma.

5 gitis before developing verrucous esophageal squamous carcinoma.

6 etically-defined, incurable subtype of human squamous carcinoma.

7 ssed in additional tumor types, such as lung squamous carcinoma.

8 14E6(WT)) develop epithelial hyperplasia and squamous carcinomas.

9 ncreased in mouse skin papillomas but not in squamous carcinomas.

10 ysplasias, and further increased in invasive squamous carcinomas.

11 r of progression from papillomas to invasive squamous carcinomas.

12 ls of 10/10 surgical specimens of human lung squamous carcinomas.

13 ally significant role in the pathogenesis of squamous carcinomas.

14 lective retinoids inhibited DNA synthesis in squamous carcinoma 1483 cells transfected with RXRalpha

15 response rate was observed in patients with squamous carcinoma (20%) compared with those with adenoc

16 The PIK3CA was amplified in 70% of squamous carcinomas, 38% of large cell carcinomas, 19% o

17 erestingly expression was almost confined to squamous carcinomas (41%), being rare in pulmonary adeno

18 nts with adenocarcinoma (46%) and those with squamous carcinoma (50%), and for patients with metastat

19 pillomas, but 1 of 96 grafts progressed to a squamous carcinoma after 1 year.

20 skin grafts, and seven grafts progressed to squamous carcinoma after 6-12 months.

21 ble stage T2N+, or T3-T4N0-3M0 biopsy-proven squamous carcinoma, age at least 18 years, PS 0 to 2, go

22 PIK3CA- and HRAS-dysregulated head and neck squamous carcinoma and could improve outcomes for many p

23 to study the function of cytoglobin in oral squamous carcinoma and response to cisplatin.

24 tumoral patterns in and between conventional squamous carcinoma and squamous carcinoma variants.

25 /progenitor cells are the cells of origin of squamous carcinoma and that cooperation between Sox2 and

26 ected patients presenting with head and neck squamous carcinoma and whose tumor cytospins had been pr

27 Sixty-one percent of squamous carcinomas and 40% of adenocarcinomas of the ce

28 ar can host metastatic deposits, and primary squamous carcinomas and adenocarcinomas.

29 ternal ear can be the site of development of squamous carcinomas and basal-cell carcinomas; the middl

30 rupted in cell lines and primary tumors from squamous carcinomas and glioblastomas.

31 Among the controls, squamous carcinomas and melanomas showed negative result

32 sebaceous tumors immunohistochemically from squamous carcinomas and melanomas, which showed negative

33 gnostic and therapeutic target in esophageal squamous carcinomas and possibly more generally in other

34 ctival intraepithelial neoplasias, 7 in situ squamous carcinomas) and 5 as nonsquamous (1 pingueculum

35 One hundred ninety-nine patients had squamous carcinoma, and 38 had adenocarcinoma/adenosquam

36 ssed in human hepatocellular carcinoma, lung squamous carcinoma, and lung adenocarcinoma in smokers.

37 1 with adenocarcinoma, rs4646903/CYP1A1 with squamous carcinoma, and rs1048943/CYP1A1 with both.

38 frequent cancer of the uterine cervix after squamous carcinoma, and the most frequent histotype is t

39 ssment of all tumors revealed fibrosarcomas, squamous carcinomas, and mixed tumors.

40 e mice, UMSCC-22B formed well-differentiated squamous carcinomas, and oral administration (daily, 5 d

41 While mixed adeno-squamous carcinomas are recognized, it remains unclear w

42 ct the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-

43 upon combined deletion of Dnmt3a and Dnmt3b, squamous carcinomas become more aggressive and metastati

44 aNp63alpha expression in normal bronchus and squamous carcinomas but not in normal lung or in adenoca

45 proto-oncogene MYC is frequently altered in squamous carcinomas, but this is insufficient to drive c

46 ary lung adenocarcinomas and 19 primary lung squamous carcinomas by immunohistochemistry.

47 ous studies have reported inhibition of A431 squamous carcinoma cell growth by nanomolar concentratio

48 human cancer xenografts derived from a human squamous carcinoma cell line (SQ-20B).

49 y in EGF- or SF-stimulated invasion, a human squamous carcinoma cell line (UM-SCC-1) was triggered at

50 ork to data from perturbation experiments in squamous carcinoma cell line A431.

51 an ovarian cancer cell line A2780, the human squamous carcinoma cell line Cal27, and their cisplatin

52 ovarian cancer cell line A2780 and the human squamous carcinoma cell line Cal27.

53 The SQ20B head and neck squamous carcinoma cell line demonstrated loss of EGF-de

54 Gingival fibroblasts and the oral human squamous carcinoma cell line HSC-2 were exposed to inter

55 of nude mice transplanted with a human oral squamous carcinoma cell line revealed that serum alpha-N

56 ation assays against the human head and neck squamous carcinoma cell line SCC25 after 72 h of treatme

57 he expression of the TbetaR-II receptor in a squamous carcinoma cell line that expressed reduced leve

58 nt path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilize

59 1 (RAIG1), which was induced by ATRA in the squamous carcinoma cell line UMSCC-22B.

60 Using a squamous carcinoma cell line we show that endogenous acc

61 he full-length human GKLF from an esophageal squamous carcinoma cell line.

62 d two Fz (Fz-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC).

63 Three human head and neck squamous carcinoma cell lines (UMSCC1, UMSCC14A, and UMS

64 dy-state neddylation of Cul1 and Cul3 in two squamous carcinoma cell lines harboring DCN1 amplificati

65 cing TGFalpha or COX-2 expression in several squamous carcinoma cell lines, indicating alterations in

66 taR-II) serine-threonine kinase in two human squamous carcinoma cell lines.

67 ated by p38alpha/beta and required for human squamous carcinoma cell quiescence in vivo.

68 Head and neck squamous carcinoma cell xenografts treated with concurre

69 and induced apoptosis of human head and neck squamous carcinoma cells (HNSCC).

70 ciated RhoGEF (LARG)) in human head and neck squamous carcinoma cells (HNSCC-HSC-3 cell line).

71 cer stem-like cells (CSC), including in oral squamous carcinoma cells (OSCC).

72 eceptor (EGFR) in the malignant phenotype of squamous carcinoma cells (SCC).

73 ry cytokines in oral fibroblasts, oral human squamous carcinoma cells and macrophages in vitro.

74 ndent kinase inhibitor p21WAF1 in both human squamous carcinoma cells and normal keratinocytes overex

75 equired for Notch-induced differentiation of squamous carcinoma cells and TERT-immortalized keratinoc

76 ivation is a general mechanism by which oral squamous carcinoma cells are resistant to TNF killing an

77 ocks cell cycle progression of head and neck squamous carcinoma cells at G(1)-S and G(2)-M by inducin

78 porter level simultaneously in head and neck squamous carcinoma cells by quantitative live microscopy

79 We used KLN 205 squamous carcinoma cells embedded in an agarose gel and

80 esponse in monolayer and 3D cultures of A431 squamous carcinoma cells following photosensitization by

81 re unable to lead the collective invasion of squamous carcinoma cells in an organotypic skin model.

82 cancer cells, and LU-HNSCC-25 head and neck squamous carcinoma cells in phosphate buffered saline.

83 es loaded with EGFR-directed siRNA to murine squamous carcinoma cells in vitro reduced EGFR expressio

84 transcutaneous injection of 5 X 10(5) murine squamous carcinoma cells into the floor of the mouth of

85 the beta4-dependent signaling in A431 human squamous carcinoma cells is dependent on the syndecan fa

86 Ectopic expression of p12(DOC-1) in squamous carcinoma cells led to the reversion of in vitr

87 The addition of EGF to either A431 squamous carcinoma cells or DiFi colon cancer cells resu

88 Ectopic expression of p12 in squamous carcinoma cells reversed the malignant phenotyp

89 We found that HSC-3 human squamous carcinoma cells survived and grew readily as mo

90 minant negative Fyn decreases the ability of squamous carcinoma cells to invade through Matrigel in v

91 , we report that the migration of breast and squamous carcinoma cells toward either lysophosphatidic

92 athymic mice and radiosensitization of human squamous carcinoma cells transfected with a vector expre

93 nalogue 13 against SCC25 human head and neck squamous carcinoma cells was 18 nM, suggesting lack of t

94 RNA levels and zinc-induced apoptosis in rat squamous carcinoma cells were reduced by specific small

95 Here, squamous carcinoma cells were seeded at different starti

96 ation (IR) we have studied human mammary and squamous carcinoma cells which are autocrine growth regu

97 s a key cytoprotective pathway in A431 human squamous carcinoma cells which is activated in response

98 In contrast, transfection of H226 human lung squamous carcinoma cells with sense-VEGF121 or sense-VEG

99 m primary keratinocytes, transformed Pam 212 squamous carcinoma cells, and metastases of Pam 212.

100 dentify tumor cells, both adenocarcinoma and squamous carcinoma cells, and to generate a classifier o

101 In A431 squamous carcinoma cells, decorin proteoglycan or protei

102 s overexpressing DeltaNp63alpha and in human squamous carcinoma cells, DeltaNp63alpha physically asso

103 When delivered into squamous carcinoma cells, phosphopeptides spanning Y1068

104 and differentiation of SqCC/Y1 head and neck squamous carcinoma cells, they were transfected with RAR

105 Here, we extend this observation to squamous carcinoma cells, which express high levels of M

106 ratinocytes (HaCaT) as well as head and neck squamous carcinoma cells.

107 enhance radiation-induced apoptosis in A431 squamous carcinoma cells.

108 ed on the activation SAPK/JNKs in SiHa human squamous carcinoma cells.

109 d sustained phosphorylation of MAP kinase in squamous carcinoma cells.

110 GF-mediated induction of Cox-2 in human oral squamous carcinoma cells.

111 cts of ALRT1550 on cellular proliferation in squamous carcinoma cells.

112 1, was identified and characterized in human squamous carcinoma cells.

113 lation of the IGF-IR in bladder, breast, and squamous carcinoma cells.

114 initiate GJ assembly de novo in A431D human squamous carcinoma cells.

115 for curcumin-mediated radiosensitization of squamous carcinoma cells.

116 trate of IP6K2) induced cell death in SCC22A squamous carcinoma cells.

117 l factor for quiescent but not proliferative squamous carcinoma cells.

118 hown that p38 activation induces dormancy of squamous carcinoma cells.

119 ith erlotinib in SQ20B and gefitinib in HSC3 squamous carcinoma cells.

120 The role of lncRNA LINC00346 in cutaneous squamous carcinoma (cSCC) was examined.

121 NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4-NUT fusion oncopr

122 Squamous carcinoma-derived A431 cells were used because

123 Squamous carcinomas developed in a multistage pathway ex

124 ps receiving UV treatment; unequivocal human squamous carcinomas developed in two of these.

125 way and reinforced the fate of club cells to squamous carcinoma development.

126 chemically induced Hras mutations to promote squamous carcinoma development.

127 adenocarcinoma (12 of 23 patients; 52%) and squamous carcinoma (eight of 12 patients; 66%).

128 In this patient, verrucous squamous carcinoma evolved from chronic esophagitis, squ

129 A subset of ocular invasive conjunctival squamous carcinomas express high levels of PD-L1 and CD8

130 analysed 64 primary untreated head and neck squamous carcinoma for the loss of imprinting in the IGF

131 In addition, we analyzed 37 oral squamous carcinomas for EGFR expression and found 24.3%

132 though cytokeratin expression was typical of squamous carcinoma, gene expression profiling was done t

133 Four patients with squamous carcinoma had nodal metastases and 5 had MFN.

134 SiHa cells are derived from a human cervical squamous carcinoma, harbor a fully integrated copy of th

135 n molecular mechanisms of adenocarcinoma and squamous carcinoma histology was also determined via the

136 development and progression of head and neck squamous carcinoma (HNSC) are largely unknown.

137 We studied 11 head and neck squamous carcinoma (HNSC) cell lines and 46 primary tumo

138 we studied several karyotyped head and neck squamous carcinoma (HNSCC) cell lines (UMSCC-17A, -17B,

139 ciated with the development of head and neck squamous carcinoma (HNSCC)-in particular, oropharyngeal

140 Head and neck squamous carcinomas (HNSCC) present as dense epithelioid

141 ote invasion and metastasis in head and neck squamous carcinomas (HNSCCs), a finding that unveils new

142 Only a subset of squamous carcinomas, however, express the gene at levels

143 In breast cancer specimens and head-neck squamous carcinomas, however, uridine cleavage was only

144 advanced laryngeal (LSCC) and hypopharyngeal squamous carcinoma (HPSCC) remains unclear.

145 ell carcinoma (SCC) cells, we cultured human squamous carcinoma (HSC-3) cells in suspension on plates

146 two popular chemotherapy drugs on human oral squamous carcinoma (HSC-3) cells.

147 so plays oncogenic roles in the formation of squamous carcinoma in several organs, including the esop

148 d that 29% (12/42) of human Bowen's disease (squamous carcinoma in situ) or SCC cases had absent or r

149 of the chromosome 11q13 in breast cancer and squamous carcinomas in the head and neck results in freq

150 p63 genomic sequence was amplified in 88% of squamous carcinomas, in 42% of large cell carcinomas, an

151 These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption

152 markedly sensitized transgenic epidermis to squamous carcinoma induction following a single dose of

153 during normal epithelial cell migration and squamous carcinoma invasion.

154 uisite for normal keratinocyte migration and squamous carcinoma invasion.

155 ma it was 1.17 0.08, and for signet cell and squamous carcinomas it was 0.91 0.11 and 0.796 0.21 mm(2

156 in human differentiated myeloid (THP-1) and squamous carcinoma (KB-31) cell lines.

157 n cancer condition characterized by multiple squamous-carcinoma-like locally invasive skin tumors tha

158 ls with p53 functional status in a series of squamous carcinoma lines has revealed an association bet

159 on in multiple primary and established human squamous carcinoma lines resulted in enhanced expression

160 Lung squamous carcinoma (LUSC) is a highly metastatic disease

161 ts with NSCLC, with higher frequency in lung squamous carcinomas (LUSC).

162 is suggests that deltaNp63 overexpression in squamous carcinomas may serve to maintain the basal cell

163 vestigated differential gene expression in a squamous carcinoma model established in syngeneic mice.

164 relate with histological classification with squamous carcinomas more frequently MAGE-A positive than

165 d treatment data from this study for 31 SCC7 squamous carcinoma murine leg tumor cases-16 hypoxic boo

166 In squamous carcinomas myofibroblasts were not prognostic d

167 ary carcinomas, we found that development of squamous carcinomas occurs independently of CtsB.

168 e have been the most active single agents in squamous carcinoma of the cervix identified so far by th

169 rove response rates and possible survival in squamous carcinoma of the cervix.

170 oducible multi-stage progression to invasive squamous carcinoma of the epidermis has been achieved in

171 treatment of locally advanced, nonmetastatic squamous carcinoma of the head and neck (HNC).

172 Squamous carcinoma of the head and neck and esophageal c

173 on of new active agents for the treatment of squamous carcinoma of the head and neck remains a high p

174 c amplification of p63 in the development of squamous carcinoma of the lung and that patients with NS

175 Patients with stage III or IV squamous carcinoma of the oral cavity, oropharynx, or hy

176 A renal transplant recipient with recurrent squamous carcinoma of the scalp underwent an excision th

177 identified the lymphatics in dysplasias and squamous carcinomas of the cervix and skin.

178 Squamous carcinomas of the cervix, skin, esophagus, and

179 papillomavirus-infected lesions and advanced squamous carcinomas of the cervix.

180 nges have been defined for centrally arising squamous carcinomas of the lung, they have been poorly d

181 The most noticeable lesions were invasive squamous carcinomas of the skin and oral mucosa.

182 ntiated neuroendocrine carcinoma, three; and squamous carcinoma, one.

183 n important component of the early stages in squamous carcinoma progression may be a modest decrease

184 1 years); 44% and 35% had adenocarcinoma and squamous carcinoma, respectively; and more patients enro

185 -SDT) could induce apoptosis in human tongue squamous carcinoma SAS cells through mitochondrial pathw

186 lysed 30 primary invasive oral and laryngeal squamous carcinomas (SC), with concurrent dysplastic les

187 ineteen patients had adenocarcinoma (AD), 14 squamous carcinoma (SCC), and seven poorly differentiate

188 The radiation responses of two squamous carcinomas, SCC-9 (oropharynx) and HEP-2 (laryn

189 ain are resistant to the development of skin squamous carcinomas (SCCs) induced by an activated Ras o

190 rray comparative genomic hybridization in 21 squamous carcinomas (SqCas) and 16 adenocarcinomas (AdCa

191 Our results show that in squamous carcinoma T-HEp3 cells, which display low PERK-

192 ng SqCCs were more similar to those of other squamous carcinomas than to alterations in lung ADCs.

193 In squamous carcinomas, TP63 is commonly amplified, and Del

194 a significant growth inhibition of colon and squamous carcinoma tumor xenografts.

195 between conventional squamous carcinoma and squamous carcinoma variants.

196 in clinical specimens of human head and neck squamous carcinoma, we found evidence that TGF-beta/Notc

197 deltaNp63 is overexpressed in squamous carcinomas where it is associated with prolifer

198 ly, c-Myc plus Bcl-XL transformants mimicked squamous carcinomas, whereas H-Ras-, EGFR-, and Akt-driv

199 tinocytes or cells derived from HPV-negative squamous carcinomas, which exhibited only slight decreas

200 h esophageal cancer (700 adenocarcinoma, 353 squamous carcinoma) who underwent R0 esophagectomy with

201 GEMM tumors (mNC) were poorly differentiated squamous carcinomas with high expression of MYC that met

202 re would affect the biology of an orthotopic squamous carcinoma xenograft.